# emapper version: emapper-2.0.1 emapper DB: 2.0
# command: ./emapper.py  -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T12.45/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/Bin_prokka//MAG.T12.45/MAG.T12.45.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T12.45/MAG.T12.45 --usemem --override
# time: Wed Feb 25 23:07:41 2026
#query_name	seed_eggNOG_ortholog	seed_ortholog_evalue	seed_ortholog_score	best_tax_level	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	taxonomic scope	eggNOG OGs	best eggNOG OG	COG Functional cat.	eggNOG free text desc.
MAG.T12.45_00001	1209072.ALBT01000033_gene1686	2.2e-23	115.9	Gammaproteobacteria	rutB												Bacteria	1MV0W@1224,1RU8R@1236,COG1335@1,COG1335@2	NA|NA|NA	Q	Amidases related to nicotinamidase
MAG.T12.45_00002	365528.KB891208_gene2813	3.8e-107	394.4	Frankiales	rutB												Bacteria	2I9AW@201174,4ERJC@85013,COG1335@1,COG1335@2	NA|NA|NA	Q	PFAM Isochorismatase
MAG.T12.45_00003	326424.FRAAL6407	8.7e-153	547.4	Frankiales	atzF		3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120		R00005	RC02756	ko00000,ko00001,ko01000				Bacteria	2GSBS@201174,4ERN1@85013,COG0154@1,COG0154@2,COG2105@1,COG2105@2	NA|NA|NA	J	Amidase
MAG.T12.45_00004	1172188.KB911821_gene1996	9.1e-155	553.9	Intrasporangiaceae													Bacteria	2HXIC@201174,4FH0P@85021,COG0471@1,COG0471@2	NA|NA|NA	P	Sodium:sulfate symporter transmembrane region
MAG.T12.45_00006	195250.CM001776_gene511	1.5e-76	293.1	Synechococcus			1.1.1.219	ko:K00091					ko00000,ko01000				Bacteria	1G2DP@1117,1H3Z1@1129,COG0451@1,COG0451@2	NA|NA|NA	M	NmrA-like family
MAG.T12.45_00007	411459.RUMOBE_00192	7.4e-11	73.2	Blautia													Bacteria	1VEJY@1239,24QJW@186801,3Y0K2@572511,COG3326@1,COG3326@2	NA|NA|NA	S	Psort location CytoplasmicMembrane, score
MAG.T12.45_00008	2002.JOEQ01000009_gene6516	1.6e-62	246.1	Streptosporangiales	yplQ			ko:K11068					ko00000,ko02042				Bacteria	2GJGQ@201174,4EIGX@85012,COG1272@1,COG1272@2	NA|NA|NA	S	Haemolysin-III related
MAG.T12.45_00009	1122182.KB903816_gene1683	1.1e-53	216.5	Micromonosporales	ykoE			ko:K16925		M00582			ko00000,ko00002,ko02000	3.A.1.30			Bacteria	2IDAN@201174,4D9S6@85008,COG4721@1,COG4721@2	NA|NA|NA	S	ABC-type cobalt transport system, permease component
MAG.T12.45_00010	1305732.JAGG01000001_gene909	7e-109	401.7	Actinobacteria	ykoD		3.6.3.24	ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16785,ko:K16786,ko:K16787	ko02010,ko02024,map02010,map02024	M00239,M00440,M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5			Bacteria	2I2G4@201174,COG0619@1,COG0619@2,COG1123@1,COG4172@2	NA|NA|NA	P	Cobalt transport protein
MAG.T12.45_00011	1306174.JODP01000001_gene5170	1.7e-50	206.5	Actinobacteria	yeaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	4.2.1.9,5.1.3.15	ko:K01687,ko:K01792	ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R01209,R02739,R04441,R05070	RC00468,RC00563,RC01714	ko00000,ko00001,ko00002,ko01000				Bacteria	2IIUH@201174,COG0676@1,COG0676@2	NA|NA|NA	G	Belongs to the glucose-6-phosphate 1-epimerase family
MAG.T12.45_00012	1121017.AUFG01000020_gene2298	2.4e-37	161.8	Intrasporangiaceae	dcdA		3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044				Bacteria	2IJ94@201174,4FHCM@85021,COG2131@1,COG2131@2	NA|NA|NA	F	MafB19-like deaminase
MAG.T12.45_00013	926569.ANT_20770	3.1e-16	90.9	Chloroflexi	mrx1		1.20.4.3	ko:K18917					ko00000,ko01000				Bacteria	2G75B@200795,COG0695@1,COG0695@2	NA|NA|NA	O	Glutathione S-transferase, N-terminal domain
MAG.T12.45_00014	1205910.B005_1121	2.2e-94	352.8	Streptosporangiales	amiA			ko:K01436,ko:K06048					ko00000,ko01000,ko01002				Bacteria	2GK05@201174,4EHXK@85012,COG1473@1,COG1473@2	NA|NA|NA	S	Peptidase dimerisation domain
MAG.T12.45_00015	768671.ThimaDRAFT_1447	1.3e-79	303.9	Chromatiales	ggt		2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100		R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002				Bacteria	1MUV6@1224,1SMH6@1236,1X0JB@135613,COG0405@1,COG0405@2	NA|NA|NA	E	Gamma-glutamyltranspeptidase
MAG.T12.45_00016	479432.Sros_8729	6.3e-148	530.8	Streptosporangiales	nplT		3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13		Bacteria	2GJUT@201174,4EIF5@85012,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain
MAG.T12.45_00017	1120949.KB903328_gene8960	7.2e-09	68.6	Micromonosporales													Bacteria	2DMZ3@1,2IQMH@201174,32UHB@2,4DFK7@85008	NA|NA|NA	S	Predicted membrane protein (DUF2157)
MAG.T12.45_00018	1229780.BN381_100069	3.5e-32	146.0	Bacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG0577@1,COG0577@2	NA|NA|NA	V	efflux transmembrane transporter activity
MAG.T12.45_00019	1313172.YM304_38290	1.5e-38	167.2	Actinobacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GMC4@201174,COG0577@1,COG0577@2	NA|NA|NA	V	ABC-type antimicrobial peptide transport system, permease component
MAG.T12.45_00020	1229780.BN381_100067	3.7e-60	238.4	unclassified Actinobacteria (class)	hrtA		3.6.3.25	ko:K02003,ko:K06020,ko:K09810,ko:K09814	ko02010,map02010	M00255,M00257,M00258			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125			Bacteria	2GNB3@201174,3UXF5@52018,COG1136@1,COG1136@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T12.45_00021	1120950.KB892759_gene6277	2.4e-77	296.2	Propionibacteriales													Bacteria	2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2	NA|NA|NA	D	PFAM Stage II sporulation D domain protein
MAG.T12.45_00022	101510.RHA1_ro03323	2.2e-90	338.6	Nocardiaceae													Bacteria	2GMSB@201174,4FXCP@85025,COG2013@1,COG2013@2	NA|NA|NA	T	Mitochondrial biogenesis AIM24
MAG.T12.45_00023	1032480.MLP_00530	3.9e-107	395.2	Propionibacteriales	pit			ko:K03306					ko00000	2.A.20			Bacteria	2GJHK@201174,4DND5@85009,COG0306@1,COG0306@2	NA|NA|NA	P	Phosphate transporter family
MAG.T12.45_00024	1050202.KB913024_gene55	2.7e-116	425.6	Actinopolysporales													Bacteria	2GKGM@201174,407NC@622450,COG2733@1,COG2733@2	NA|NA|NA	S	Protein of unknown function (DUF445)
MAG.T12.45_00026	397278.JOJN01000007_gene3359	3.7e-117	428.7	Propionibacteriales													Bacteria	2GWA2@201174,2Z9VM@2,4DQ3R@85009,COG1524@1	NA|NA|NA	S	mannose-ethanolamine phosphotransferase activity
MAG.T12.45_00027	345341.KUTG_04253	1.7e-138	499.2	Pseudonocardiales	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100		R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT4		Bacteria	2I2EE@201174,4E0K3@85010,COG0297@1,COG0297@2	NA|NA|NA	G	Glycosyl transferase 4-like domain
MAG.T12.45_00028	1380347.JNII01000006_gene1701	3.3e-129	468.4	Frankiales	glgC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2768	Bacteria	2I2EF@201174,4ERNH@85013,COG0448@1,COG0448@2	NA|NA|NA	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAG.T12.45_00029	526226.Gbro_2863	2e-82	312.8	Gordoniaceae		GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKTP@201174,4GBZC@85026,COG0119@1,COG0119@2	NA|NA|NA	E	HMGL-like
MAG.T12.45_00030	1068978.AMETH_6925	2.8e-51	208.0	Pseudonocardiales	pstB		3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Bacteria	2GJQ3@201174,4DY3N@85010,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MAG.T12.45_00033	1380370.JIBA01000003_gene2731	1.5e-78	300.1	Intrasporangiaceae	flpE			ko:K02282					ko00000,ko02035,ko02044				Bacteria	2GNHI@201174,4FG1C@85021,COG4963@1,COG4963@2	NA|NA|NA	D	chromosome partitioning
MAG.T12.45_00034	196162.Noca_3114	1.2e-33	150.2	Propionibacteriales	cpaB			ko:K02279					ko00000,ko02035,ko02044				Bacteria	2INHS@201174,4DSV2@85009,COG3745@1,COG3745@2	NA|NA|NA	U	Flp pilus assembly protein RcpC/CpaB
MAG.T12.45_00035	1298863.AUEP01000002_gene1395	4.4e-19	101.7	Propionibacteriales													Bacteria	29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009	NA|NA|NA	S	TadE-like protein
MAG.T12.45_00036	1298863.AUEP01000002_gene1394	4.6e-88	332.4	Propionibacteriales													Bacteria	2IAR7@201174,4DTBY@85009,COG4655@1,COG4655@2	NA|NA|NA	S	Putative Flp pilus-assembly TadE/G-like
MAG.T12.45_00037	1298863.AUEP01000002_gene1395	3.5e-19	102.1	Propionibacteriales													Bacteria	29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009	NA|NA|NA	S	TadE-like protein
MAG.T12.45_00038	28444.JODQ01000008_gene1197	2.3e-140	506.5	Streptosporangiales													Bacteria	2GMAV@201174,4EHD3@85012,COG0392@1,COG0392@2	NA|NA|NA	I	Lysylphosphatidylglycerol synthase TM region
MAG.T12.45_00040	529884.Rhola_00013450	5.1e-30	137.1	Microbacteriaceae	iolTB			ko:K02057,ko:K03466		M00221			ko00000,ko00002,ko02000,ko03036	3.A.1.2,3.A.12			Bacteria	2GM9E@201174,4FK9K@85023,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_00041	67257.JODR01000002_gene1060	3.6e-95	354.8	Actinobacteria			3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	2GJDV@201174,COG1129@1,COG1129@2	NA|NA|NA	G	ABC transporter
MAG.T12.45_00042	591159.ACEZ01000134_gene2353	6.1e-145	521.2	Actinobacteria	cydC			ko:K06148,ko:K16012,ko:K16013,ko:K16014	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1,3.A.1.129			Bacteria	2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2	NA|NA|NA	V	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD
MAG.T12.45_00043	1134445.AJJM01000001_gene2720	2.7e-127	462.6	Actinobacteria	cydC			ko:K06148,ko:K16012,ko:K16013,ko:K16014	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1,3.A.1.129			Bacteria	2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2	NA|NA|NA	V	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD
MAG.T12.45_00044	1123320.KB889730_gene6071	1.2e-121	443.7	Actinobacteria													Bacteria	2GIWI@201174,COG3850@1,COG3850@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_00045	35754.JNYJ01000014_gene4724	7.2e-120	437.2	Micromonosporales	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Bacteria	2GMFV@201174,4DATV@85008,COG1294@1,COG1294@2	NA|NA|NA	C	cytochrome d ubiquinol oxidase, subunit
MAG.T12.45_00046	469371.Tbis_2750	3.9e-169	601.3	Pseudonocardiales	cydA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337	Bacteria	2GJE4@201174,4DZRD@85010,COG1271@1,COG1271@2	NA|NA|NA	C	Cytochrome bd-type quinol oxidase, subunit 1
MAG.T12.45_00047	367299.JOEE01000002_gene2547	1.3e-67	263.5	Intrasporangiaceae			1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120		R01708	RC00116	ko00000,ko00001,ko01000				Bacteria	2GJ6R@201174,4FG84@85021,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo/keto reductase family
MAG.T12.45_00048	266940.Krad_3698	4e-50	206.1	Actinobacteria			2.7.13.3,3.1.3.3	ko:K07315,ko:K07654,ko:K07675	ko02020,map02020	M00461,M00473			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021				Bacteria	2IHH3@201174,COG2208@1,COG2208@2,COG3850@1,COG3850@2	NA|NA|NA	KT	stage II sporulation
MAG.T12.45_00049	633147.Olsu_0349	4.1e-64	251.1	Coriobacteriia				ko:K06147,ko:K12531	ko02020,map02020	M00326			ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2I6AF@201174,4CUQX@84998,COG5265@1,COG5265@2	NA|NA|NA	O	ABC transporter
MAG.T12.45_00050	1894.JOER01000030_gene416	1.4e-37	163.3	Actinobacteria													Bacteria	2GMRP@201174,COG4758@1,COG4758@2	NA|NA|NA	S	Cell wall-active antibiotics response 4TMS YvqF
MAG.T12.45_00051	369723.Strop_3578	3.9e-14	84.3	Micromonosporales		GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2E65S@1,2IMEQ@201174,330UF@2,4DERM@85008	NA|NA|NA	S	Domain of unknown function (DUF3817)
MAG.T12.45_00052	1210045.ALNP01000011_gene1032	3.6e-25	122.1	Actinobacteria	surf1			ko:K14998					ko00000,ko03029	3.D.4.8			Bacteria	2GMGB@201174,COG3346@1,COG3346@2	NA|NA|NA	S	SURF1-like protein
MAG.T12.45_00054	994479.GL877878_gene2035	1.4e-12	79.7	Pseudonocardiales													Bacteria	2DRBP@1,2IGPY@201174,33B4I@2,4E5JR@85010	NA|NA|NA	S	Domain of unknown function (DUF4307)
MAG.T12.45_00055	1504319.GM45_3100	5.2e-44	184.1	unclassified Actinobacteria (class)	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Bacteria	2GNZV@201174,3UWPU@52018,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MAG.T12.45_00056	526225.Gobs_0935	1.6e-131	476.1	Frankiales	ilvA		4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0356	Bacteria	2GJAG@201174,4ES0N@85013,COG1171@1,COG1171@2	NA|NA|NA	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit
MAG.T12.45_00057	1435356.Y013_00880	6.6e-93	347.1	Nocardiaceae	ung	GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJ9Z@201174,4FXPC@85025,COG0692@1,COG0692@2	NA|NA|NA	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MAG.T12.45_00058	1336208.JADY01000018_gene3237	5e-18	97.8	Rhodospirillales	dadA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.5.1	ko:K00285	ko00360,map00360		R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000				Bacteria	1MVIZ@1224,2JPUI@204441,2TRT9@28211,COG0665@1,COG0665@2	NA|NA|NA	E	Oxidative deamination of D-amino acids
MAG.T12.45_00059	1122933.JNIY01000003_gene727	1.2e-63	250.8	Cellulomonadaceae				ko:K03281					ko00000	2.A.49			Bacteria	2GJHP@201174,4F2KU@85016,COG0038@1,COG0038@2	NA|NA|NA	P	Voltage gated chloride channel
MAG.T12.45_00060	1499967.BAYZ01000019_gene6314	4.2e-24	117.9	unclassified Bacteria	sixA		3.6.1.55	ko:K03574,ko:K08296					ko00000,ko01000,ko03400				Bacteria	2NRKX@2323,COG2062@1,COG2062@2	NA|NA|NA	T	Histidine phosphatase superfamily (branch 1)
MAG.T12.45_00061	1255043.TVNIR_2461	7.1e-14	83.6	Chromatiales				ko:K11312					ko00000				Bacteria	1QUHG@1224,1T1Z6@1236,1WZ1B@135613,COG0662@1,COG0662@2	NA|NA|NA	G	PFAM Cupin 2, conserved barrel
MAG.T12.45_00062	1120949.KB903335_gene9688	1.9e-32	145.6	Actinobacteria													Bacteria	2H6QZ@201174,COG4803@1,COG4803@2	NA|NA|NA	S	membrane protein of uknown function UCP014873
MAG.T12.45_00064	1032480.MLP_42530	2.6e-34	152.5	Actinobacteria													Bacteria	2I6ZG@201174,COG0639@1,COG0639@2	NA|NA|NA	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MAG.T12.45_00065	1211815.CBYP010000005_gene232	5.7e-16	92.0	Actinobacteria													Bacteria	2GVAC@201174,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAG.T12.45_00066	1380393.JHVP01000007_gene4343	1.6e-86	326.2	Actinobacteria				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN8P@201174,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_00067	685727.REQ_07710	1e-29	137.1	Nocardiaceae													Bacteria	2I2JW@201174,4G9F0@85025,COG0500@1,COG2226@2	NA|NA|NA	Q	Thiopurine S-methyltransferase (TPMT)
MAG.T12.45_00068	469371.Tbis_3425	4e-47	194.1	Pseudonocardiales	panD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0139,iYL1228.KPN_00139	Bacteria	2IHTC@201174,4E2JG@85010,COG0853@1,COG0853@2	NA|NA|NA	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MAG.T12.45_00069	1137268.AZXF01000026_gene2413	1.7e-26	126.3	Streptosporangiales				ko:K06950					ko00000				Bacteria	2IAVS@201174,4EJTM@85012,COG1418@1,COG1418@2	NA|NA|NA	S	PFAM metal-dependent phosphohydrolase, HD sub domain
MAG.T12.45_00070	760011.Spico_1472	2.3e-112	412.1	Spirochaetes	metAA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS11970,iLJ478.TM0881	Bacteria	2J60Z@203691,COG1897@1,COG1897@2	NA|NA|NA	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MAG.T12.45_00071	350054.Mflv_0939	5.7e-11	73.2	Mycobacteriaceae													Bacteria	23B65@1762,2EK1R@1,2GWKM@201174,33DS7@2	NA|NA|NA	S	Phospholipase_D-nuclease N-terminal
MAG.T12.45_00072	478741.JAFS01000001_gene1899	1.3e-54	219.9	unclassified Verrucomicrobia	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004			iECUMN_1333.ECUMN_1592	Bacteria	37G8S@326457,46UJB@74201,COG0623@1,COG0623@2	NA|NA|NA	I	Enoyl-(Acyl carrier protein) reductase
MAG.T12.45_00073	1304865.JAGF01000001_gene688	1.7e-156	558.9	Actinobacteria													Bacteria	28IW2@1,2IA78@201174,2Z8UC@2	NA|NA|NA		
MAG.T12.45_00074	1304865.JAGF01000001_gene687	5.1e-267	926.8	Cellulomonadaceae	hppA		3.6.1.1	ko:K15987	ko00190,map00190				ko00000,ko00001,ko01000	3.A.10.1			Bacteria	2GN8B@201174,4F0E3@85016,COG3808@1,COG3808@2	NA|NA|NA	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force
MAG.T12.45_00077	1035308.AQYY01000002_gene962	1.8e-35	156.8	Bacteria													Bacteria	COG5340@1,COG5340@2	NA|NA|NA	K	Psort location Cytoplasmic, score
MAG.T12.45_00078	1043205.AFYF01000026_gene433	0.0	1240.7	Intrasporangiaceae	helZ		2.7.11.1	ko:K08282					ko00000,ko01000				Bacteria	2GISC@201174,4FFBR@85021,COG0553@1,COG0553@2,COG4715@1,COG4715@2	NA|NA|NA	L	SNF2 family N-terminal domain
MAG.T12.45_00079	1206101.AZXC01000010_gene23	5.1e-83	314.7	Actinobacteria													Bacteria	2GIS3@201174,COG0604@1,COG0604@2	NA|NA|NA	C	alcohol dehydrogenase
MAG.T12.45_00082	983917.RGE_30170	1.7e-25	122.9	Bacteria				ko:K03830					ko00000,ko01000				Bacteria	COG1246@1,COG1246@2	NA|NA|NA	E	Belongs to the acetyltransferase family. ArgA subfamily
MAG.T12.45_00083	367299.JOEE01000003_gene2888	1.6e-11	75.9	Intrasporangiaceae													Bacteria	2HNF3@201174,4FHWW@85021,COG5652@1,COG5652@2	NA|NA|NA	S	VanZ like family
MAG.T12.45_00084	1394178.AWOO02000004_gene2330	8.9e-230	803.1	Streptosporangiales	acd												Bacteria	2GJIB@201174,4EFZX@85012,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase N terminal
MAG.T12.45_00085	1896.JOAU01000002_gene4042	3.1e-75	288.5	Actinobacteria	mtnU			ko:K11206					ko00000,ko01000				Bacteria	2GMQA@201174,COG0388@1,COG0388@2	NA|NA|NA	E	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MAG.T12.45_00086	1172179.AUKV01000016_gene2208	5.1e-189	667.5	Actinobacteria													Bacteria	2I7MG@201174,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_00087	1122609.AUGT01000009_gene3024	1.1e-18	99.0	Propionibacteriales													Bacteria	2IR0P@201174,4DS21@85009,COG0695@1,COG0695@2	NA|NA|NA	O	Glutaredoxin-like domain (DUF836)
MAG.T12.45_00088	1122182.KB903813_gene2267	1.5e-118	433.3	Micromonosporales			6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	2GIUC@201174,4DBR0@85008,COG0318@1,COG0318@2	NA|NA|NA	IQ	AMP-binding enzyme C-terminal domain
MAG.T12.45_00089	44060.JODL01000048_gene1559	2.3e-72	279.3	Actinobacteria	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K21830					ko00000				Bacteria	2GJW9@201174,COG0560@1,COG0560@2	NA|NA|NA	E	HAD-superfamily subfamily IB hydrolase, TIGR01490
MAG.T12.45_00090	1246995.AFR_08775	1.1e-64	253.4	Micromonosporales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2ID14@201174,4DCGZ@85008,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-2 family transporter protein
MAG.T12.45_00091	1122182.KB903837_gene3906	3.3e-95	355.1	Micromonosporales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GKEH@201174,4D8QU@85008,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T12.45_00092	1380393.JHVP01000002_gene1950	1.3e-109	402.9	Frankiales		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GJKH@201174,4ESBP@85013,COG0204@1,COG0204@2	NA|NA|NA	I	PFAM Phospholipid glycerol acyltransferase
MAG.T12.45_00093	1120950.KB892801_gene1769	1.9e-109	402.5	Propionibacteriales	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0501	Bacteria	2GNT1@201174,4DPEE@85009,COG0451@1,COG0451@2	NA|NA|NA	GM	GDP-mannose 4,6 dehydratase
MAG.T12.45_00094	471852.Tcur_4450	4.5e-18	96.7	Streptosporangiales	xis												Bacteria	2GQGV@201174,4EKJX@85012,COG3311@1,COG3311@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T12.45_00095	28444.JODQ01000014_gene6728	3.6e-131	474.9	Streptosporangiales	acuC			ko:K04768					ko00000			iYO844.BSU29710	Bacteria	2GJUH@201174,4EGFY@85012,COG0123@1,COG0123@2	NA|NA|NA	BQ	Histone deacetylase domain
MAG.T12.45_00096	1385519.N801_08350	3.7e-102	379.0	Intrasporangiaceae	trkH			ko:K03498					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2GKKS@201174,4FG5M@85021,COG0168@1,COG0168@2	NA|NA|NA	P	Cation transport protein
MAG.T12.45_00097	35754.JNYJ01000053_gene6709	5.5e-41	174.5	Micromonosporales	trkA			ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2IA09@201174,4DCSC@85008,COG0569@1,COG0569@2	NA|NA|NA	P	TrkA-C domain
MAG.T12.45_00098	1306174.JODP01000006_gene3453	1.4e-70	273.1	Actinobacteria	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ7D@201174,COG0345@1,COG0345@2	NA|NA|NA	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAG.T12.45_00099	1048339.KB913029_gene2309	1.2e-41	177.2	Frankiales				ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130		R10507	RC00083	ko00000,ko00001,ko01000				Bacteria	2GJTK@201174,4ERCN@85013,COG0506@1,COG0506@2	NA|NA|NA	E	Proline dehydrogenase
MAG.T12.45_00100	931627.MycrhDRAFT_6074	2.9e-66	259.2	Mycobacteriaceae													Bacteria	23CKA@1762,2GKPS@201174,COG4850@1,COG4850@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2183)
MAG.T12.45_00101	467200.ACFA01000404_gene2616	3.4e-106	391.7	Actinobacteria													Bacteria	2GJ6E@201174,COG1082@1,COG1082@2	NA|NA|NA	G	PFAM Xylose isomerase domain protein TIM barrel
MAG.T12.45_00102	570268.ANBB01000033_gene2073	1.6e-141	509.6	Streptosporangiales	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04485					ko00000,ko03400				Bacteria	2GMQ0@201174,4EG9C@85012,COG1066@1,COG1066@2	NA|NA|NA	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MAG.T12.45_00103	1150864.MILUP08_46690	3e-129	468.4	Micromonosporales	disA		2.7.7.85	ko:K07067					ko00000,ko01000				Bacteria	2GJ41@201174,4D9EZ@85008,COG1623@1,COG1623@2	NA|NA|NA	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process
MAG.T12.45_00104	1122611.KB903943_gene1465	1.5e-06	60.5	Streptosporangiales													Bacteria	2E5CN@1,2GM9T@201174,3304R@2,4EJKG@85012	NA|NA|NA		
MAG.T12.45_00105	994479.GL877880_gene3989	7.1e-61	240.0	Pseudonocardiales	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	2GKGP@201174,4DXBM@85010,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T12.45_00106	1504319.GM45_6200	0.0	1144.4	unclassified Actinobacteria (class)	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469					ko00000,ko01000,ko03032,ko03400				Bacteria	2GJ2Q@201174,3UWEZ@52018,COG0188@1,COG0188@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T12.45_00107	1283287.KB822575_gene768	2.2e-21	109.4	Propionibacteriales		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2GKZP@201174,4DR9G@85009,COG3266@1,COG3266@2	NA|NA|NA	S	Transmembrane domain of unknown function (DUF3566)
MAG.T12.45_00111	1203605.HMPREF1531_01896	5.2e-63	247.3	Propionibacteriales	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217				ko00000,ko00001,ko01000,ko03110,ko04147				Bacteria	2IFUE@201174,4DQA4@85009,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T12.45_00112	1122611.KB903952_gene5829	4.1e-40	171.8	Streptosporangiales	gluP		3.4.21.105	ko:K19225					ko00000,ko01000,ko01002				Bacteria	2GJYG@201174,4EH62@85012,COG0705@1,COG0705@2	NA|NA|NA	S	Rhomboid family
MAG.T12.45_00113	2002.JOEQ01000029_gene8208	9.9e-15	85.9	Streptosporangiales	crgA												Bacteria	2E4NY@1,2HZN4@201174,32ZHR@2,4EKK3@85012	NA|NA|NA	D	Involved in cell division
MAG.T12.45_00114	1193181.BN10_150004	1e-42	180.3	Intrasporangiaceae													Bacteria	2GJ9Y@201174,4FFV4@85021,COG3879@1,COG3879@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF881)
MAG.T12.45_00115	1123320.KB889730_gene5990	6e-77	293.9	Actinobacteria	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664,ko:K13950	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000				Bacteria	2GJUX@201174,COG0512@1,COG0512@2	NA|NA|NA	EH	Glutamine amidotransferase of anthranilate synthase
MAG.T12.45_00116	1463926.JOCA01000003_gene5189	2.6e-123	448.7	Actinobacteria	ybdL	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.17,2.6.1.88	ko:K14267,ko:K14287	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475,R08618	RC00006,RC00025	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJ7R@201174,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
MAG.T12.45_00117	1193181.BN10_800007	3.2e-72	278.5	Intrasporangiaceae				ko:K07124					ko00000				Bacteria	2GKJE@201174,4FFCH@85021,COG0300@1,COG0300@2	NA|NA|NA	S	Belongs to the short-chain dehydrogenases reductases (SDR) family
MAG.T12.45_00118	1120936.KB907212_gene5233	1.9e-12	79.3	Streptosporangiales			2.3.1.43	ko:K00650	ko00564,ko04979,map00564,map04979		R02114	RC00037,RC00055	ko00000,ko00001,ko01000				Bacteria	2IAEU@201174,4EQDC@85012,COG1075@1,COG1075@2	NA|NA|NA	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MAG.T12.45_00119	1003195.SCAT_3322	1.6e-70	272.3	Actinobacteria	pyrE		2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000			iJN678.umpS	Bacteria	2GKUQ@201174,COG0461@1,COG0461@2	NA|NA|NA	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MAG.T12.45_00120	1179773.BN6_83110	6.7e-71	273.9	Pseudonocardiales	dedA			ko:K03975					ko00000				Bacteria	2GKGR@201174,4DX3S@85010,COG0586@1,COG0586@2	NA|NA|NA	S	SNARE associated Golgi protein
MAG.T12.45_00121	465515.Mlut_02030	2.8e-71	275.0	Micrococcaceae	spoU		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	1W7E6@1268,2GM1A@201174,COG0566@1,COG0566@2	NA|NA|NA	J	rRNA methyltransferase
MAG.T12.45_00123	1961.JOAK01000012_gene6002	3.1e-44	185.7	Actinobacteria			3.2.2.21	ko:K01247	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GP69@201174,COG0122@1,COG0122@2	NA|NA|NA	L	3-methyladenine DNA glycosylase
MAG.T12.45_00125	931627.MycrhDRAFT_2921	1.4e-242	845.9	Mycobacteriaceae	fimV_2			ko:K19719	ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165				ko00000,ko00001,ko00536				Bacteria	232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2	NA|NA|NA	C	Fe-S oxidoreductase
MAG.T12.45_00126	1136417.AZWE01000070_gene1255	1.7e-75	290.0	Micromonosporales		GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085											Bacteria	2HB3P@201174,4DCV1@85008,COG2271@1,COG2271@2	NA|NA|NA	G	PFAM major facilitator superfamily MFS_1
MAG.T12.45_00127	1304865.JAGF01000001_gene119	2.6e-155	555.8	Actinobacteria	yvnB		3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025		R00191	RC00296	ko00000,ko00001,ko01000				Bacteria	2GN7G@201174,COG1409@1,COG1409@2,COG3291@1,COG3291@2	NA|NA|NA	P	PFAM PKD domain containing protein
MAG.T12.45_00128	367299.JOEE01000003_gene3004	1.4e-72	280.8	Actinobacteria													Bacteria	2IT2M@201174,COG1807@1,COG1807@2	NA|NA|NA	M	Dolichyl-phosphate-mannose-protein mannosyltransferase
MAG.T12.45_00129	263358.VAB18032_22820	2.7e-63	249.2	Micromonosporales	wbbL_1			ko:K07011					ko00000				Bacteria	2HEV5@201174,4D9DN@85008,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family group 2
MAG.T12.45_00132	1194165.CAJF01000007_gene661	6.3e-77	293.5	Microbacteriaceae	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ilvN,iJN678.ilvN	Bacteria	2GJCH@201174,4FM2D@85023,COG0440@1,COG0440@2	NA|NA|NA	E	ACT domain
MAG.T12.45_00133	1713.JOFV01000012_gene806	5.1e-259	900.2	Cellulomonadaceae	ilvB		2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKU4@201174,4F0HH@85016,COG0028@1,COG0028@2	NA|NA|NA	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type
MAG.T12.45_00134	1122236.KB905144_gene2309	4.8e-123	448.7	Nitrosomonadales													Bacteria	1MU2C@1224,2KNM3@206350,2VIDG@28216,COG5001@1,COG5001@2	NA|NA|NA	T	Putative diguanylate phosphodiesterase
MAG.T12.45_00135	1120950.KB892741_gene2670	8.2e-248	862.8	Propionibacteriales	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJIJ@201174,4DNV7@85009,COG0129@1,COG0129@2	NA|NA|NA	EG	Belongs to the IlvD Edd family
MAG.T12.45_00136	500153.JOEK01000009_gene5174	5.5e-55	221.5	Actinobacteria	rfaF			ko:K02843	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	2GMZG@201174,COG0859@1,COG0859@2	NA|NA|NA	M	PFAM glycosyl transferase family 9
MAG.T12.45_00138	1050202.KB913024_gene1971	2e-50	207.2	Actinopolysporales	sigB	GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03090					ko00000,ko03021				Bacteria	2GKSY@201174,407GP@622450,COG1191@1,COG1191@2	NA|NA|NA	K	Sigma-70 region 3
MAG.T12.45_00141	345341.KUTG_02431	2.1e-128	466.1	Pseudonocardiales													Bacteria	2HNS8@201174,4EA2Q@85010,COG2152@1,COG2152@2	NA|NA|NA	G	beta-1,4-mannooligosaccharide phosphorylase
MAG.T12.45_00142	345341.KUTG_02430	6.9e-32	143.7	Actinobacteria													Bacteria	2I5YD@201174,COG1331@1,COG1331@2	NA|NA|NA	O	Highly conserved protein containing a thioredoxin domain
MAG.T12.45_00143	710696.Intca_3045	6.7e-98	364.8	Intrasporangiaceae													Bacteria	2GNPG@201174,4FJ4K@85021,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferase
MAG.T12.45_00144	1121272.KB903290_gene4457	7.7e-09	65.5	Micromonosporales													Bacteria	2EI4A@1,2GX45@201174,33BVN@2,4DGEI@85008	NA|NA|NA		
MAG.T12.45_00146	390989.JOEG01000003_gene4476	3e-49	202.6	Micromonosporales													Bacteria	2HSM4@201174,4DFKR@85008,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T12.45_00148	479435.Kfla_4186	8.7e-157	561.2	Propionibacteriales													Bacteria	2GKCX@201174,4DPXK@85009,COG0457@1,COG0457@2,COG4995@1,COG4995@2	NA|NA|NA	K	CHAT domain
MAG.T12.45_00149	110319.CF8_3504	8e-119	434.1	Propionibacteriales			3.4.21.62	ko:K01342	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GNIX@201174,4DPVM@85009,COG1404@1,COG1404@2	NA|NA|NA	O	peptidase S8 and S53, subtilisin, kexin, sedolisin
MAG.T12.45_00150	477641.MODMU_2499	2.6e-18	98.6	Frankiales													Bacteria	2E61P@1,2II66@201174,330QX@2,4ETM0@85013	NA|NA|NA		
MAG.T12.45_00151	2045.KR76_01335	5.4e-56	224.2	Propionibacteriales				ko:K03088					ko00000,ko03021				Bacteria	2GJUI@201174,4DR64@85009,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70 region 2
MAG.T12.45_00153	1122611.KB903941_gene2200	3.3e-15	87.8	Actinobacteria													Bacteria	2IQ8I@201174,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator PadR family protein
MAG.T12.45_00154	358823.DF19_29430	1.5e-28	132.1	Actinobacteria													Bacteria	2IQ8I@201174,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator PadR family protein
MAG.T12.45_00158	1120950.KB892764_gene5614	3.8e-156	558.1	Propionibacteriales	tgs3	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000				Bacteria	2HEFF@201174,4DN7F@85009,COG1020@1,COG1020@2	NA|NA|NA	Q	Belongs to the long-chain O-acyltransferase family
MAG.T12.45_00159	479433.Caci_7582	6.8e-75	287.7	Actinobacteria				ko:K07001					ko00000				Bacteria	2IB0F@201174,COG1752@1,COG1752@2	NA|NA|NA	S	esterase of the alpha-beta hydrolase superfamily
MAG.T12.45_00161	1380370.JIBA01000014_gene2099	6.5e-18	97.4	Intrasporangiaceae													Bacteria	2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2	NA|NA|NA	S	Protein of unknown function (DUF2505)
MAG.T12.45_00162	1385518.N798_16970	4.7e-21	107.8	Intrasporangiaceae													Bacteria	2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2	NA|NA|NA	S	Protein of unknown function (DUF2505)
MAG.T12.45_00163	1394178.AWOO02000005_gene3638	0.0	1547.3	Streptosporangiales	gdhB	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100		R00243	RC00006,RC02799	ko00000,ko00001,ko01000				Bacteria	2GK0C@201174,4EGYX@85012,COG2902@1,COG2902@2	NA|NA|NA	E	Bacterial NAD-glutamate dehydrogenase
MAG.T12.45_00164	1172188.KB911820_gene2155	6.7e-12	77.4	Actinobacteria													Bacteria	2B2RZ@1,2GVDD@201174,31VC7@2	NA|NA|NA		
MAG.T12.45_00165	999549.KI421513_gene3229	3.6e-08	64.7	Alphaproteobacteria													Bacteria	1P508@1224,29A23@1,2UXRW@28211,2ZX3H@2	NA|NA|NA		
MAG.T12.45_00167	991905.SL003B_1710	2e-12	80.1	Alphaproteobacteria													Bacteria	1RBK4@1224,28P0C@1,2U4BQ@28211,2ZBWZ@2	NA|NA|NA		
MAG.T12.45_00171	991905.SL003B_1708	4.6e-22	111.3	Alphaproteobacteria													Bacteria	1NPM2@1224,2EI2S@1,2UJF2@28211,33BU6@2	NA|NA|NA		
MAG.T12.45_00174	767434.Fraau_3109	2.3e-49	201.8	Xanthomonadales	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216					ko00000,ko01000,ko03016				Bacteria	1RCY4@1224,1S3PI@1236,1X643@135614,COG0219@1,COG0219@2	NA|NA|NA	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MAG.T12.45_00175	743718.Isova_0180	2.2e-70	272.3	Promicromonosporaceae	tipA			ko:K21744					ko00000,ko03000				Bacteria	2H5GI@201174,4F45E@85017,COG0789@1,COG0789@2	NA|NA|NA	K	TipAS antibiotic-recognition domain
MAG.T12.45_00176	1961.JOAK01000002_gene1143	5e-21	107.8	Bacteria	yahN	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03329,ko:K16327					ko00000,ko02000	2.A.76.1.3,2.A.76.1.6			Bacteria	COG1280@1,COG1280@2	NA|NA|NA	E	homoserine transmembrane transporter activity
MAG.T12.45_00177	543632.JOJL01000005_gene4760	1.8e-110	407.1	Actinobacteria													Bacteria	2I2TP@201174,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_00178	543632.JOJL01000005_gene4762	2.8e-23	114.8	Actinobacteria													Bacteria	2I2Z1@201174,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulator receiver
MAG.T12.45_00179	1120950.KB892707_gene4712	1e-92	346.7	Propionibacteriales	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNAX@201174,4DNZB@85009,COG0040@1,COG0040@2	NA|NA|NA	E	ATP phosphoribosyltransferase
MAG.T12.45_00180	1121946.AUAX01000008_gene7170	6.2e-28	129.8	Micromonosporales	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	Bacteria	2IQ4D@201174,4DF5K@85008,COG0140@1,COG0140@2	NA|NA|NA	E	Phosphoribosyl-ATP
MAG.T12.45_00181	1115803.HMPREF1129_0933	6.9e-50	203.8	Actinobacteria	ribH		2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000				Bacteria	2II1Z@201174,4D5BA@85005,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MAG.T12.45_00182	1179773.BN6_62920	3.7e-16	90.9	Pseudonocardiales	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1415	Bacteria	2GIWJ@201174,4DXCJ@85010,COG0108@1,COG0108@2,COG0807@1,COG0807@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAG.T12.45_00183	1894.JOER01000020_gene3783	3.3e-77	294.3	Actinobacteria	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Bacteria	2GKBQ@201174,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_00184	314230.DSM3645_19063	0.0	1179.9	Planctomycetes	dld			ko:K18930					ko00000				Bacteria	2IYAH@203682,COG0247@1,COG0247@2,COG0277@1,COG0277@2	NA|NA|NA	C	FAD linked oxidases, C-terminal domain
MAG.T12.45_00185	983917.RGE_19390	6.9e-114	417.9	unclassified Burkholderiales				ko:K03281,ko:K07085					ko00000	2.A.49,2.A.81			Bacteria	1KNQF@119065,1MUVM@1224,2VN42@28216,COG0569@1,COG0569@2,COG2985@1,COG2985@2	NA|NA|NA	P	Predicted Permease Membrane Region
MAG.T12.45_00186	1137269.AZWL01000007_gene4285	7.9e-166	590.5	Actinobacteria			3.2.1.10,3.2.1.20,3.2.1.93	ko:K01182,ko:K01187,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13,GH31		Bacteria	2GKS4@201174,COG0366@1,COG0366@2	NA|NA|NA	G	alpha amylase, catalytic
MAG.T12.45_00187	1463885.KL578480_gene3542	5.3e-42	177.2	Actinobacteria	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363		ko:K06886					ko00000				Bacteria	2IKPF@201174,COG2346@1,COG2346@2	NA|NA|NA	O	PFAM globin
MAG.T12.45_00188	1123320.KB889629_gene7846	1.9e-188	665.6	Actinobacteria													Bacteria	2GIZA@201174,COG0702@1,COG0702@2	NA|NA|NA	GM	Nad-dependent epimerase dehydratase
MAG.T12.45_00189	1089455.MOPEL_132_00510	5e-59	235.0	Dermatophilaceae				ko:K22044					ko00000,ko02000	1.A.23.3			Bacteria	2GMFK@201174,4F6NP@85018,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive ion channel
MAG.T12.45_00190	44060.JODL01000011_gene1967	3.4e-42	178.3	Actinobacteria													Bacteria	299JI@1,2GMZP@201174,2ZWN1@2	NA|NA|NA	S	Domain of unknown function (DUF5063)
MAG.T12.45_00191	479432.Sros_9311	2e-167	595.5	Streptosporangiales	ask		1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN0G@201174,4EG8Z@85012,COG0527@1,COG0527@2	NA|NA|NA	E	ACT domain
MAG.T12.45_00192	593907.Celgi_2847	9e-139	500.0	Cellulomonadaceae	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3708c	Bacteria	2GJJ8@201174,4F0DR@85016,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MAG.T12.45_00197	337191.KTR9_4794	6.8e-61	241.1	Actinobacteria				ko:K03496					ko00000,ko03036,ko04812				Bacteria	2IHZI@201174,COG1192@1,COG1192@2	NA|NA|NA	D	PFAM Cobyrinic acid a,c-diamide synthase
MAG.T12.45_00198	479431.Namu_4682	4.7e-159	568.2	Actinobacteria	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344	Bacteria	2GJUT@201174,COG0366@1,COG0366@2	NA|NA|NA	G	alpha amylase, catalytic
MAG.T12.45_00199	479431.Namu_4683	1.1e-172	612.8	Frankiales				ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1			Bacteria	2GJCM@201174,4ES4E@85013,COG3842@1,COG3842@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
MAG.T12.45_00200	1095767.CAHD01000191_gene271	1.2e-168	600.1	Cellulomonadaceae	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344	Bacteria	2GJUT@201174,4F26G@85016,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha-amylase domain
MAG.T12.45_00201	479431.Namu_4684	5.3e-122	444.1	Actinobacteria	malG	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10110,ko:K15772	ko02010,map02010	M00194,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22		iLJ478.TM1202,iSSON_1240.SSON_4210,iYL1228.KPN_04421	Bacteria	2I2EZ@201174,COG3833@1,COG3833@2	NA|NA|NA	P	PFAM binding-protein-dependent transport systems inner membrane component
MAG.T12.45_00202	479431.Namu_4685	2.8e-208	731.5	Actinobacteria	malF	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K02025,ko:K10109,ko:K10118,ko:K10233,ko:K15771	ko02010,map02010	M00194,M00196,M00201,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.28,3.A.1.1.32,3.A.1.1.8		iZ_1308.Z5631	Bacteria	2GJGB@201174,COG1175@1,COG1175@2	NA|NA|NA	G	PFAM binding-protein-dependent transport systems inner membrane component
MAG.T12.45_00203	479431.Namu_4686	1.1e-125	456.8	Bacteria				ko:K02027,ko:K15770	ko02010,map02010	M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2			Bacteria	COG2182@1,COG2182@2	NA|NA|NA	G	maltose binding
MAG.T12.45_00204	1001240.GY21_16135	1.2e-52	214.2	Microbacteriaceae				ko:K02027,ko:K15770	ko02010,map02010	M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2			Bacteria	2HSEH@201174,4FMZA@85023,COG2182@1,COG2182@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
MAG.T12.45_00205	1961.JOAK01000011_gene5882	1.4e-37	162.2	Actinobacteria	glnB			ko:K04751	ko02020,map02020				ko00000,ko00001				Bacteria	2IKN1@201174,COG0347@1,COG0347@2	NA|NA|NA	K	Belongs to the P(II) protein family
MAG.T12.45_00206	1120950.KB892769_gene5401	1.3e-142	513.1	Propionibacteriales	amt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03320					ko00000,ko02000	1.A.11		iNJ661.Rv2920c	Bacteria	2GIZK@201174,4DNW9@85009,COG0004@1,COG0004@2	NA|NA|NA	P	Ammonium Transporter Family
MAG.T12.45_00209	1122622.ATWJ01000008_gene2889	1.1e-206	726.5	Intrasporangiaceae	ams		2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100		R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000		GH13		Bacteria	2GKT9@201174,4FEVJ@85021,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain
MAG.T12.45_00212	1123401.JHYQ01000022_gene1149	1.1e-88	333.2	Gammaproteobacteria	XK27_05675												Bacteria	1R6D9@1224,1T0S7@1236,COG0627@1,COG0627@2,COG4947@1,COG4947@2	NA|NA|NA	S	Putative esterase
MAG.T12.45_00213	1299327.I546_5516	6.3e-67	260.8	Mycobacteriaceae			3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120		R05287	RC00697	ko00000,ko00001,ko01000				Bacteria	23BTU@1762,2IBB1@201174,COG1011@1,COG1011@2	NA|NA|NA	S	Haloacid dehalogenase-like hydrolase
MAG.T12.45_00214	926561.KB900617_gene1274	4.6e-128	464.9	Halanaerobiales	scrA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.211	ko:K02755,ko:K02756,ko:K02757,ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	M00269,M00271	R00811	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9		iYO844.BSU38050	Bacteria	1TP5X@1239,247WT@186801,3WBUR@53433,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	phosphotransferase system, EIIB
MAG.T12.45_00215	441769.ABFU01000009_gene2768	2.3e-98	366.3	Bacillus	scrB	GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000		GH32	iECSF_1327.ECSF_2568,iYO844.BSU38040	Bacteria	1TPAE@1239,1ZCBA@1386,4H9Y7@91061,COG1621@1,COG1621@2	NA|NA|NA	G	invertase
MAG.T12.45_00216	298655.KI912266_gene5611	7.9e-71	275.0	Frankiales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_00217	1133850.SHJG_5771	5.3e-15	88.2	Actinobacteria													Bacteria	2GKW3@201174,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_00218	292564.Cyagr_1692	4.9e-135	487.6	Cyanobacteria	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	1.20.4.1	ko:K03325,ko:K03741					ko00000,ko01000,ko02000	2.A.59		iYO844.BSU25790	Bacteria	1G05E@1117,COG0798@1,COG0798@2	NA|NA|NA	P	PFAM Sodium Bile acid symporter family
MAG.T12.45_00219	1209989.TepiRe1_2456	1.8e-21	108.2	Thermoanaerobacterales													Bacteria	1VEYC@1239,24QMF@186801,42H6Q@68295,COG0526@1,COG0526@2	NA|NA|NA	CO	redox-active disulfide protein 2
MAG.T12.45_00220	479431.Namu_2554	7.9e-20	102.8	Actinobacteria													Bacteria	2GUBI@201174,COG0526@1,COG0526@2	NA|NA|NA	CO	redox-active disulfide protein 2
MAG.T12.45_00221	479431.Namu_2555	1.6e-146	525.8	Bacteria				ko:K07089					ko00000				Bacteria	COG0701@1,COG0701@2	NA|NA|NA	S	Predicted permease
MAG.T12.45_00222	1304865.JAGF01000001_gene3289	5.2e-20	103.6	Actinobacteria	arsR			ko:K03892					ko00000,ko03000				Bacteria	2GQU5@201174,COG0640@1,COG0640@2	NA|NA|NA	K	PFAM regulatory protein, ArsR
MAG.T12.45_00223	1035308.AQYY01000002_gene103	2.9e-24	118.6	Peptococcaceae	cdr2												Bacteria	1TPWW@1239,2484C@186801,2606T@186807,COG0446@1,COG0446@2	NA|NA|NA	P	pyridine nucleotide-disulphide oxidoreductase dimerisation
MAG.T12.45_00224	591159.ACEZ01000001_gene6027	5.8e-60	237.7	Actinobacteria	glpF			ko:K02440,ko:K06188					ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2			Bacteria	2GMG4@201174,COG0580@1,COG0580@2	NA|NA|NA	G	Belongs to the MIP aquaporin (TC 1.A.8) family
MAG.T12.45_00225	1906.SFRA_16750	5.7e-57	226.9	Actinobacteria	arsC		1.20.4.1	ko:K03741					ko00000,ko01000				Bacteria	2IHR3@201174,COG0394@1,COG0394@2	NA|NA|NA	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAG.T12.45_00226	1121019.AUMN01000033_gene2670	3.7e-42	177.6	Actinobacteria													Bacteria	2GPFR@201174,COG4374@1,COG4374@2	NA|NA|NA	S	PIN domain
MAG.T12.45_00227	1380386.JIAW01000031_gene3544	1.3e-19	102.1	Actinobacteria													Bacteria	2HD6A@201174,COG2002@1,COG2002@2	NA|NA|NA	K	toxin-antitoxin pair type II binding
MAG.T12.45_00228	477641.MODMU_1575	1.2e-18	98.6	Actinobacteria		GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007											Bacteria	2FDS3@1,2GUMT@201174,345T0@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T12.45_00229	1146883.BLASA_1416	5.7e-35	153.3	Actinobacteria	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007		ko:K07171					ko00000,ko01000,ko02048				Bacteria	2IMGQ@201174,COG2337@1,COG2337@2	NA|NA|NA	T	Evidence 2b Function of strongly homologous gene
MAG.T12.45_00231	710696.Intca_0789	1.7e-137	496.1	Intrasporangiaceae													Bacteria	2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
MAG.T12.45_00232	1137268.AZXF01000040_gene3328	6.9e-22	109.8	Bacteria				ko:K06218					ko00000,ko02048				Bacteria	COG2026@1,COG2026@2	NA|NA|NA	DJ	nuclease activity
MAG.T12.45_00233	1121924.ATWH01000005_gene2551	1.6e-25	121.7	Actinobacteria													Bacteria	2BAGM@1,2H8NG@201174,323X7@2	NA|NA|NA		
MAG.T12.45_00234	1210045.ALNP01000010_gene1189	1.2e-103	383.3	Actinobacteria	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1201c	Bacteria	2GIZ9@201174,COG2171@1,COG2171@2	NA|NA|NA	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
MAG.T12.45_00236	1122611.KB903974_gene2937	6.8e-36	157.1	Streptosporangiales													Bacteria	2GMPH@201174,4EJKB@85012,COG1853@1,COG1853@2	NA|NA|NA	S	Flavin reductase like domain
MAG.T12.45_00237	1120950.KB892823_gene520	1.3e-94	354.0	Propionibacteriales	vanW												Bacteria	2GISH@201174,4DN8K@85009,COG2720@1,COG2720@2	NA|NA|NA	V	Putative peptidoglycan binding domain
MAG.T12.45_00238	1184609.KILIM_030_00650	7.1e-50	203.0	Dermatophilaceae	fdxA			ko:K05524					ko00000				Bacteria	2IKVN@201174,4F715@85018,COG1146@1,COG1146@2	NA|NA|NA	C	4Fe-4S binding domain
MAG.T12.45_00239	1246995.AFR_38740	3.3e-133	481.5	Micromonosporales	dapC												Bacteria	2GJMI@201174,4DB04@85008,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
MAG.T12.45_00240	253839.SSNG_00156	4.2e-70	271.2	Actinobacteria													Bacteria	2DKWQ@1,2I3CS@201174,30MQE@2	NA|NA|NA	S	Glyoxalase-like domain
MAG.T12.45_00242	710696.Intca_0346	1.4e-214	752.3	Actinobacteria	nagC			ko:K02003,ko:K02565,ko:K15545		M00258			ko00000,ko00002,ko02000,ko03000	3.A.1			Bacteria	2ICG2@201174,COG1321@1,COG1321@2	NA|NA|NA	K	iron dependent repressor
MAG.T12.45_00245	356851.JOAN01000021_gene2322	1.5e-29	137.1	Micromonosporales													Bacteria	2GMDB@201174,4DAZM@85008,COG1670@1,COG1670@2	NA|NA|NA	J	Acetyltransferase (GNAT) domain
MAG.T12.45_00246	1211815.CBYP010000005_gene232	1.4e-17	97.4	Actinobacteria													Bacteria	2GVAC@201174,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAG.T12.45_00247	1146883.BLASA_2357	2.6e-63	248.8	Actinobacteria				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN8P@201174,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_00249	1463936.JOJI01000077_gene65	2.3e-24	118.6	Actinobacteria													Bacteria	2IBP1@201174,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00250	1463934.JOCF01000050_gene7607	3.5e-14	86.3	Actinobacteria			2.1.1.107	ko:K02303,ko:K22010	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121,M00839	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000,ko02022				Bacteria	2H0E2@201174,COG2203@1,COG2203@2,COG3707@1,COG3707@2	NA|NA|NA	T	ANTAR
MAG.T12.45_00251	1304865.JAGF01000001_gene1186	2.2e-52	213.8	Actinobacteria													Bacteria	2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_00252	686340.Metal_2787	1.3e-134	486.5	Proteobacteria	cpgS			ko:K05716			R03298	RC00900	ko00000,ko01000				Bacteria	1MV4C@1224,COG2403@1,COG2403@2	NA|NA|NA	S	cyclic 2,3-diphosphoglycerate synthetase activity
MAG.T12.45_00253	593907.Celgi_2417	1.8e-164	585.5	Cellulomonadaceae	pfkA		2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019			iJN678.pfkA	Bacteria	2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2	NA|NA|NA	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MAG.T12.45_00254	1150399.AQYK01000002_gene3209	2.3e-184	652.9	Microbacteriaceae													Bacteria	2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2	NA|NA|NA	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins
MAG.T12.45_00255	1035308.AQYY01000002_gene896	1.2e-20	105.9	Bacteria													Bacteria	2DNVN@1,32ZD5@2	NA|NA|NA	S	Lsr2
MAG.T12.45_00256	1380370.JIBA01000015_gene318	2.6e-60	239.6	Intrasporangiaceae													Bacteria	2GK3A@201174,4FFEB@85021,COG1680@1,COG1680@2	NA|NA|NA	V	Beta-lactamase
MAG.T12.45_00257	1504672.669787050	2.2e-11	75.9	Comamonadaceae													Bacteria	1R95F@1224,28J0Q@1,2VJZ5@28216,2Z8XV@2,4A9RS@80864	NA|NA|NA		
MAG.T12.45_00259	411483.FAEPRAA2165_03445	3.6e-74	285.0	Ruminococcaceae				ko:K05833		M00247			ko00000,ko00002,ko02000				Bacteria	1TPAN@1239,247WW@186801,3WHK4@541000,COG1101@1,COG1101@2	NA|NA|NA	S	Psort location CytoplasmicMembrane, score
MAG.T12.45_00260	574087.Acear_1446	1.2e-73	283.5	Halanaerobiales	WQ51_06230			ko:K01989,ko:K05832,ko:K05833		M00247			ko00000,ko00002,ko02000				Bacteria	1TPDJ@1239,249P1@186801,3WA9B@53433,COG4120@1,COG4120@2	NA|NA|NA	S	PFAM Branched-chain amino acid transport system permease component
MAG.T12.45_00261	1120947.ATUX01000005_gene1328	1.4e-72	280.0	Actinobacteria				ko:K01989,ko:K05832		M00247			ko00000,ko00002,ko02000				Bacteria	2GKNV@201174,4D55W@85005,COG2984@1,COG2984@2	NA|NA|NA	S	ABC transporter substrate binding protein
MAG.T12.45_00262	298653.Franean1_0560	1.5e-26	124.8	Frankiales	cspC			ko:K03704					ko00000,ko03000				Bacteria	2GQRU@201174,4ETAA@85013,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock protein
MAG.T12.45_00263	1206733.BAGC01000043_gene189	1.7e-62	246.5	Nocardiaceae				ko:K07454					ko00000				Bacteria	2HHZ8@201174,4G1UT@85025,COG3440@1,COG3440@2	NA|NA|NA	V	HNH endonuclease
MAG.T12.45_00265	408672.NBCG_02347	5.8e-27	127.9	Propionibacteriales	rpoC												Bacteria	2GKXN@201174,4DQPK@85009,COG0739@1,COG0739@2	NA|NA|NA	M	PFAM NLP P60 protein
MAG.T12.45_00266	235985.BBPN01000058_gene7562	6.1e-83	313.9	Streptacidiphilus	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GMP7@201174,2NGNU@228398,COG1249@1,COG1249@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
MAG.T12.45_00267	479433.Caci_0809	3.3e-142	511.5	Actinobacteria	bccA		6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIZP@201174,COG4770@1,COG4770@2	NA|NA|NA	I	carboxylase
MAG.T12.45_00269	219305.MCAG_03785	2.7e-162	578.6	Micromonosporales													Bacteria	2GJQ9@201174,4DCEF@85008,COG0665@1,COG0665@2	NA|NA|NA	E	Glycine D-amino acid oxidases (deaminating)
MAG.T12.45_00270	367299.JOEE01000004_gene1059	4.1e-44	184.9	Intrasporangiaceae				ko:K07005					ko00000				Bacteria	2GJ76@201174,4FGDI@85021,COG3467@1,COG3467@2	NA|NA|NA	S	Pyridoxamine 5'-phosphate oxidase
MAG.T12.45_00271	1380370.JIBA01000014_gene1864	5e-209	733.8	Intrasporangiaceae	bioA												Bacteria	2GKF6@201174,4FE6A@85021,COG0161@1,COG0161@2	NA|NA|NA	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T12.45_00272	1380354.JIAN01000007_gene161	2e-59	235.3	Actinobacteria	asnC			ko:K03718					ko00000,ko03000				Bacteria	2GP1P@201174,COG1522@1,COG1522@2	NA|NA|NA	K	AsnC family
MAG.T12.45_00273	526225.Gobs_1721	1.9e-211	741.9	Frankiales			1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,4ERRA@85013,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T12.45_00274	1396141.BATP01000059_gene2437	1.1e-109	403.3	Verrucomicrobiae	ldhA		1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120		R00704	RC00044	ko00000,ko00001,ko01000				Bacteria	2ITY0@203494,46SGM@74201,COG1052@1,COG1052@2	NA|NA|NA	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
MAG.T12.45_00275	37919.EP51_00995	9.7e-195	686.4	Nocardiaceae			1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,4FTXB@85025,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T12.45_00276	1504319.GM45_4525	2.3e-117	429.1	unclassified Actinobacteria (class)				ko:K11069	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GKVG@201174,3UWJS@52018,COG0687@1,COG0687@2	NA|NA|NA	E	Bacterial extracellular solute-binding protein
MAG.T12.45_00279	134676.ACPL_8199	0.0	1103.6	Micromonosporales	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110		R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000				Bacteria	2GJFP@201174,4D8UR@85008,COG0376@1,COG0376@2	NA|NA|NA	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MAG.T12.45_00280	1463861.JNXE01000006_gene5743	9.2e-43	179.9	Actinobacteria	furA			ko:K03711,ko:K22297					ko00000,ko03000				Bacteria	2IFBR@201174,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T12.45_00281	1150399.AQYK01000001_gene1604	1.3e-232	813.1	Microbacteriaceae				ko:K06994					ko00000				Bacteria	2GJ5A@201174,4FK7G@85023,COG1033@1,COG1033@2,COG2409@1,COG2409@2	NA|NA|NA	D	MMPL family
MAG.T12.45_00282	1150399.AQYK01000001_gene1603	1.8e-39	171.4	Microbacteriaceae	yhgE			ko:K01421					ko00000				Bacteria	2GKEM@201174,4FM86@85023,COG1511@1,COG1511@2	NA|NA|NA	S	YhgE Pip domain protein
MAG.T12.45_00284	649831.L083_4309	4.6e-33	147.9	Micromonosporales													Bacteria	2IK2E@201174,4DIYC@85008,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_00285	1035308.AQYY01000001_gene2568	7.4e-264	916.4	Peptococcaceae	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	1TP4M@1239,247WH@186801,260UV@186807,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAG.T12.45_00287	1298863.AUEP01000003_gene2844	2.8e-42	178.3	Propionibacteriales	flgN												Bacteria	2B12R@1,2IQ5J@201174,31TG8@2,4DRX1@85009	NA|NA|NA	S	FlgN protein
MAG.T12.45_00289	460265.Mnod_6097	6.4e-124	451.1	Methylobacteriaceae	chrA			ko:K07240					ko00000,ko02000	2.A.51.1			Bacteria	1JRJU@119045,1MUBW@1224,2TRXF@28211,COG2059@1,COG2059@2	NA|NA|NA	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family
MAG.T12.45_00290	134676.ACPL_4271	3.5e-60	237.7	Actinobacteria													Bacteria	2IK0B@201174,COG4275@1,COG4275@2	NA|NA|NA	S	chromate resistance protein
MAG.T12.45_00291	591159.ACEZ01000200_gene2508	5.6e-37	160.6	Actinobacteria	chrB												Bacteria	2IPJU@201174,COG4275@1,COG4275@2	NA|NA|NA	S	Chromate resistance exported protein
MAG.T12.45_00292	1385520.N802_11095	6.9e-87	327.0	Actinobacteria													Bacteria	2AAWD@1,2IG0D@201174,3109H@2	NA|NA|NA	S	Alkylmercury lyase
MAG.T12.45_00293	1146883.BLASA_4885	6.6e-129	467.2	Frankiales	nirK		1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	2GPUP@201174,4ES9Q@85013,COG2132@1,COG2132@2,COG4454@1,COG4454@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T12.45_00294	222534.KB893760_gene3963	6.6e-26	123.6	Frankiales	VY92_09940			ko:K09796					ko00000,ko03110				Bacteria	2IR3D@201174,4EW8E@85013,COG2847@1,COG2847@2	NA|NA|NA	S	Pfam:DUF461
MAG.T12.45_00295	1179773.BN6_18910	6.3e-31	140.6	Pseudonocardiales	XK27_02315												Bacteria	2IMR2@201174,4E5VC@85010,COG5646@1,COG5646@2	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T12.45_00296	1240349.ANGC01000051_gene4101	8.3e-148	530.4	Nocardiaceae													Bacteria	2CA5R@1,2GM6V@201174,2Z81H@2,4FVE9@85025	NA|NA|NA		
MAG.T12.45_00297	1713.JOFV01000017_gene106	6.8e-41	173.3	Cellulomonadaceae	ywzG												Bacteria	2IQSE@201174,4F1CD@85016,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator PadR-like family
MAG.T12.45_00299	47839.CCAU010000009_gene1334	3.9e-33	147.5	Mycobacteriaceae													Bacteria	23A2K@1762,2IC9E@201174,COG2105@1,COG2105@2	NA|NA|NA	S	Gamma-glutamyl cyclotransferase, AIG2-like
MAG.T12.45_00300	512565.AMIS_58000	1.6e-49	202.6	Micromonosporales													Bacteria	2HF5Y@201174,4DIXE@85008,COG5592@1,COG5592@2	NA|NA|NA	S	Hemerythrin HHE cation binding domain
MAG.T12.45_00301	196162.Noca_0769	3.8e-33	147.5	Propionibacteriales	flgK			ko:K02396	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2GNXQ@201174,4DNRW@85009,COG1256@1,COG1256@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T12.45_00302	196162.Noca_0770	6.9e-79	300.8	Propionibacteriales	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464		ko:K02397	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IA40@201174,4DNBS@85009,COG1344@1,COG1344@2	NA|NA|NA	N	Bacterial flagellin C-terminal helical region
MAG.T12.45_00303	1298863.AUEP01000003_gene2847	4.4e-36	157.5	Propionibacteriales	fliW			ko:K13626					ko00000,ko02035				Bacteria	2GT61@201174,4DRPC@85009,COG1699@1,COG1699@2	NA|NA|NA	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MAG.T12.45_00304	1283287.KB822581_gene1520	9.2e-23	112.5	Propionibacteriales	csrA			ko:K03563,ko:K13626	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111				ko00000,ko00001,ko02035,ko03019				Bacteria	2GRPH@201174,4DS3Q@85009,COG1551@1,COG1551@2	NA|NA|NA	T	Global regulator protein family
MAG.T12.45_00306	1298863.AUEP01000003_gene2815	2.1e-259	901.7	Propionibacteriales	flhA	GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944		ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	2IB5S@201174,4DP8V@85009,COG1298@1,COG1298@2	NA|NA|NA	NU	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MAG.T12.45_00307	1033730.CAHG01000007_gene2549	3e-117	428.7	Propionibacteriales	flhB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820	ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02000,ko02035,ko02044	1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	2HF6J@201174,4DQ2U@85009,COG1377@1,COG1377@2	NA|NA|NA	NU	FlhB HrpN YscU SpaS Family
MAG.T12.45_00308	1298863.AUEP01000003_gene2817	5e-78	297.7	Propionibacteriales	fliR			ko:K02421,ko:K03228,ko:K13820	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	2IDEX@201174,4DPR0@85009,COG1684@1,COG1684@2	NA|NA|NA	NU	Bacterial export proteins, family 1
MAG.T12.45_00309	397278.JOJN01000001_gene2924	4.7e-31	140.2	Propionibacteriales	fliQ			ko:K02420	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	2IQ8H@201174,4DRPB@85009,COG1987@1,COG1987@2	NA|NA|NA	NU	Bacterial export proteins, family 3
MAG.T12.45_00310	935866.JAER01000042_gene2756	5.6e-74	285.0	Propionibacteriales	fliP			ko:K02419,ko:K03226	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	2GP63@201174,4DPT8@85009,COG1338@1,COG1338@2	NA|NA|NA	NU	FliP family
MAG.T12.45_00312	1120950.KB892784_gene183	3.2e-168	598.2	Propionibacteriales	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130		R02060	RC00408	ko00000,ko00001,ko01000			iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206	Bacteria	2GN87@201174,4DNFP@85009,COG1109@1,COG1109@2	NA|NA|NA	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAG.T12.45_00313	1410634.JHVD01000002_gene282	4.3e-11	74.7	Propionibacteriales	putA		1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130		R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000				Bacteria	2GM5R@201174,4DNV8@85009,COG0506@1,COG0506@2,COG1012@1,COG1012@2	NA|NA|NA	CE	Proline dehydrogenase
MAG.T12.45_00314	235985.BBPN01000048_gene8264	2e-77	296.2	Streptacidiphilus	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575		ko:K10805	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571	Bacteria	2GJ1B@201174,2NEH9@228398,COG1946@1,COG1946@2	NA|NA|NA	I	Acyl-CoA thioesterase
MAG.T12.45_00319	1172188.KB911822_gene720	8.1e-50	203.4	Intrasporangiaceae				ko:K09763					ko00000				Bacteria	2IHUS@201174,4FH6W@85021,COG1547@1,COG1547@2	NA|NA|NA	S	Domain of unknown function (DUF309)
MAG.T12.45_00320	1150399.AQYK01000001_gene352	9.4e-33	146.7	Microbacteriaceae	yfbT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043136,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050084,GO:0050286,GO:0050308,GO:0050897	3.1.3.23	ko:K19270					ko00000,ko01000				Bacteria	2GNX0@201174,4FPH8@85023,COG0637@1,COG0637@2	NA|NA|NA	V	Haloacid dehalogenase-like hydrolase
MAG.T12.45_00322	266940.Krad_0158	6.3e-88	330.9	Actinobacteria	fpg		3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKAM@201174,COG0266@1,COG0266@2	NA|NA|NA	L	Belongs to the FPG family
MAG.T12.45_00323	1048339.KB913029_gene1638	9.3e-30	136.3	Actinobacteria													Bacteria	2CQNK@1,2I83S@201174,323RQ@2	NA|NA|NA	S	Family of unknown function (DUF5318)
MAG.T12.45_00324	1504319.GM45_1640	1.7e-155	556.6	unclassified Actinobacteria (class)	mrcB		2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	2GK21@201174,3UX6W@52018,COG0744@1,COG0744@2	NA|NA|NA	M	Transglycosylase
MAG.T12.45_00325	1449347.JQLN01000005_gene4485	1.9e-113	416.4	Kitasatospora													Bacteria	2GJYA@201174,2M0JK@2063,COG5650@1,COG5650@2	NA|NA|NA	S	Pfam:DUF2029
MAG.T12.45_00326	397278.JOJN01000003_gene1778	1.3e-53	217.2	Propionibacteriales													Bacteria	2GJJX@201174,4DNS3@85009,COG0787@1,COG0787@2	NA|NA|NA	M	Alanine racemase, N-terminal domain
MAG.T12.45_00327	1348663.KCH_39330	2.4e-127	462.2	Kitasatospora	femA												Bacteria	2GJUD@201174,2M0RF@2063,COG2348@1,COG2348@2	NA|NA|NA	V	FemAB family
MAG.T12.45_00328	1121927.GOHSU_53_00040	2e-35	154.8	Gordoniaceae	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904		ko:K02990	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	2IQHD@201174,4GEI3@85026,COG0360@1,COG0360@2	NA|NA|NA	J	Binds together with S18 to 16S ribosomal RNA
MAG.T12.45_00329	471853.Bcav_4180	9.6e-49	199.9	Actinobacteria	ssb	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	2GMM3@201174,COG0629@1,COG0629@2	NA|NA|NA	L	single-stranded DNA-binding protein
MAG.T12.45_00330	479431.Namu_5367	1.5e-28	131.7	Frankiales	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02963,ko:K03111,ko:K15125	ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133	M00178			br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400				Bacteria	2IQ92@201174,4ESZ0@85013,COG0238@1,COG0238@2	NA|NA|NA	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MAG.T12.45_00331	1122611.KB903955_gene5558	1.8e-43	182.2	Streptosporangiales	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02939	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKX7@201174,4EIIV@85012,COG0359@1,COG0359@2	NA|NA|NA	J	binds to the 23S rRNA
MAG.T12.45_00332	745411.B3C1_05887	2e-23	117.1	Gammaproteobacteria	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000				Bacteria	1QVUF@1224,1T2J7@1236,COG1211@1,COG1211@2,COG5295@1,COG5295@2	NA|NA|NA	UW	this gene contains a nucleotide ambiguity which may be the result of a sequencing error
MAG.T12.45_00333	1463853.JOHW01000024_gene4633	6.6e-33	147.1	Actinobacteria	ptpA		3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	2IM0Q@201174,COG0394@1,COG0394@2	NA|NA|NA	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAG.T12.45_00336	1095767.CAHD01000130_gene1318	1.2e-52	212.6	Cellulomonadaceae	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02876	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2II6M@201174,4F16W@85016,COG0200@1,COG0200@2	NA|NA|NA	J	Binds to the 23S rRNA
MAG.T12.45_00337	1121933.AUHH01000003_gene1376	1.2e-14	85.1	Propionibacteriales	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02907	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQV0@201174,4DSCE@85009,COG1841@1,COG1841@2	NA|NA|NA	J	Ribosomal protein L30
MAG.T12.45_00338	105420.BBPO01000022_gene5786	1.6e-66	259.2	Streptacidiphilus	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02988	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJW8@201174,2NG8M@228398,COG0098@1,COG0098@2	NA|NA|NA	J	Ribosomal protein S5, C-terminal domain
MAG.T12.45_00339	1048339.KB913029_gene2766	1e-39	169.5	Frankiales	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02881	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKTX@201174,4ESW2@85013,COG0256@1,COG0256@2	NA|NA|NA	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MAG.T12.45_00340	1133850.SHJG_5812	2.1e-75	288.5	Actinobacteria	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02933	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GK35@201174,COG0097@1,COG0097@2	NA|NA|NA	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MAG.T12.45_00341	1121385.AQXW01000004_gene2023	3.4e-54	217.6	Dermacoccaceae	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02994	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1ZVXC@145357,2IHQZ@201174,COG0096@1,COG0096@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MAG.T12.45_00342	446471.Xcel_0640	4.5e-25	119.8	Promicromonosporaceae	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02954	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ8R@201174,4F4WT@85017,COG0199@1,COG0199@2	NA|NA|NA	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MAG.T12.45_00343	266940.Krad_0700	3e-47	194.1	Actinobacteria	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02931	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJW7@201174,COG0094@1,COG0094@2	NA|NA|NA	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MAG.T12.45_00346	28444.JODQ01000001_gene2722	1.6e-34	151.8	Streptosporangiales	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02956	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQA0@201174,4EK2G@85012,COG0184@1,COG0184@2	NA|NA|NA	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MAG.T12.45_00347	591157.SSLG_04999	2.9e-75	288.9	Actinobacteria	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKQF@201174,COG0196@1,COG0196@2	NA|NA|NA	H	Belongs to the ribF family
MAG.T12.45_00348	1283283.ATXA01000005_gene2038	3.8e-156	558.1	Frankiales	pepP		3.4.11.9	ko:K01262					ko00000,ko01000,ko01002				Bacteria	2GM7D@201174,4ERTK@85013,COG0006@1,COG0006@2	NA|NA|NA	E	Creatinase/Prolidase N-terminal domain
MAG.T12.45_00349	1304865.JAGF01000001_gene3790	1.1e-79	303.5	Cellulomonadaceae	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177					ko00000,ko01000,ko03016				Bacteria	2GJZK@201174,4F0NH@85016,COG0130@1,COG0130@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MAG.T12.45_00350	479433.Caci_7740	3.1e-49	201.4	Actinobacteria	rbfA			ko:K02834					ko00000,ko03009				Bacteria	2IKXP@201174,COG0858@1,COG0858@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MAG.T12.45_00351	591158.SSMG_04921	1.4e-28	132.1	Actinobacteria	ylxP			ko:K09764					ko00000				Bacteria	2IQW4@201174,COG1550@1,COG1550@2	NA|NA|NA	S	protein conserved in bacteria
MAG.T12.45_00352	106370.Francci3_3562	2.2e-202	711.8	Frankiales	infB			ko:K02519					ko00000,ko03012,ko03029				Bacteria	2GKPH@201174,4ERI2@85013,COG0532@1,COG0532@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MAG.T12.45_00354	247156.NFA_26570	3.1e-225	788.1	Nocardiaceae	nuoL	GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GIT4@201174,4FWHS@85025,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
MAG.T12.45_00355	471852.Tcur_4406	4e-167	594.7	Streptosporangiales	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iSDY_1059.SDY_2473	Bacteria	2GKBN@201174,4EH1X@85012,COG1008@1,COG1008@2	NA|NA|NA	C	Proton-conducting membrane transporter
MAG.T12.45_00356	1123320.KB889574_gene5648	4.8e-152	544.7	Actinobacteria	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GMGX@201174,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_00357	1380347.JNII01000005_gene3065	1.8e-195	688.7	Frankiales	trpB		4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GP7D@201174,4ES9G@85013,COG1350@1,COG1350@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MAG.T12.45_00358	1048339.KB913029_gene2590	2e-116	425.6	Frankiales	hepS	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110		R09247	RC00279	ko00000,ko00001,ko01000,ko01006				Bacteria	2GMB4@201174,4ERU8@85013,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
MAG.T12.45_00359	285514.JNWO01000023_gene102	1.5e-79	303.1	Actinobacteria	rarD			ko:K05786					ko00000,ko02000	2.A.7.7			Bacteria	2GKCP@201174,COG2962@1,COG2962@2	NA|NA|NA	S	RarD protein
MAG.T12.45_00360	1464048.JNZS01000019_gene2358	1.3e-48	200.3	Micromonosporales				ko:K03294					ko00000	2.A.3.2			Bacteria	2GMFE@201174,4DD1H@85008,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
MAG.T12.45_00361	44060.JODL01000034_gene3306	8.3e-128	463.4	Actinobacteria	oorB		1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GMI5@201174,COG1013@1,COG1013@2	NA|NA|NA	C	Ferredoxin oxidoreductase
MAG.T12.45_00362	266940.Krad_3445	3.4e-96	358.2	Actinobacteria	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000				Bacteria	2GPXV@201174,COG0169@1,COG0169@2	NA|NA|NA	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MAG.T12.45_00364	1136417.AZWE01000022_gene2611	1.1e-31	143.3	Micromonosporales													Bacteria	2ENA9@1,2IS82@201174,33FXZ@2,4DF28@85008	NA|NA|NA		
MAG.T12.45_00365	1123023.JIAI01000001_gene6982	2.3e-08	65.5	Pseudonocardiales				ko:K06893					ko00000				Bacteria	2HPCK@201174,4E7Y5@85010,COG5485@1,COG5485@2	NA|NA|NA	S	SnoaL-like polyketide cyclase
MAG.T12.45_00366	1380370.JIBA01000012_gene3687	4.8e-30	136.7	Actinobacteria													Bacteria	2EAYY@1,2I2ZT@201174,334ZV@2	NA|NA|NA	S	Protein of unknown function (DUF4242)
MAG.T12.45_00367	1283299.AUKG01000005_gene135	1.3e-12	81.6	Rubrobacteria													Bacteria	2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2	NA|NA|NA	U	Involved in the tonB-independent uptake of proteins
MAG.T12.45_00368	78245.Xaut_1357	3.7e-49	201.8	Xanthobacteraceae	aldA		1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	1MU1V@1224,2TQR1@28211,3EYWS@335928,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T12.45_00369	1504319.GM45_0755	3.2e-194	684.9	unclassified Actinobacteria (class)	petD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944		ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162			ko00000,ko00001,ko00002,ko00194,ko03029				Bacteria	2GJ1E@201174,3UWCW@52018,COG1290@1,COG1290@2	NA|NA|NA	C	Cytochrome b/b6/petB
MAG.T12.45_00370	1193181.BN10_360026	3.9e-166	591.7	Intrasporangiaceae	cho	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03763,ko:K05984	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GMC0@201174,4FEF6@85021,COG0322@1,COG0322@2,COG2176@1,COG2176@2	NA|NA|NA	L	Contains 3'-5'exonuclease domain
MAG.T12.45_00371	196162.Noca_3127	6.6e-21	106.3	Actinobacteria													Bacteria	2ES7R@1,2IQ6C@201174,33JSG@2	NA|NA|NA		
MAG.T12.45_00372	1048339.KB913029_gene4617	8e-12	75.9	Actinobacteria													Bacteria	2EGHN@1,2GSZ1@201174,33A9R@2	NA|NA|NA		
MAG.T12.45_00373	561175.KB894094_gene1431	1.7e-133	482.6	Streptosporangiales	pimB		2.4.1.346,3.2.1.8	ko:K01181,ko:K13668			R11703,R11704		ko00000,ko01000,ko01003		GT4		Bacteria	2GM6D@201174,4EHII@85012,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T12.45_00374	471852.Tcur_2117	1.7e-54	220.3	Streptosporangiales													Bacteria	2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_00375	1306174.JODP01000009_gene6550	2e-24	119.4	Actinobacteria													Bacteria	2IBDE@201174,COG2197@1,COG2197@2	NA|NA|NA	T	Two component transcriptional regulator, luxr family
MAG.T12.45_00376	1122138.AQUZ01000033_gene3595	1.6e-33	149.1	Propionibacteriales													Bacteria	2IFH4@201174,4DRBM@85009,COG2867@1,COG2867@2	NA|NA|NA	I	Polyketide cyclase / dehydrase and lipid transport
MAG.T12.45_00378	1896.JOAU01000001_gene4484	9.2e-12	77.4	Actinobacteria													Bacteria	2EN8E@1,2GMI1@201174,33FW7@2	NA|NA|NA		
MAG.T12.45_00379	1048339.KB913029_gene4594	6.2e-60	237.7	Frankiales	yvaK		3.1.1.1	ko:K03928					ko00000,ko01000				Bacteria	2GM1Y@201174,4ETTX@85013,COG1647@1,COG1647@2	NA|NA|NA	S	Serine aminopeptidase, S33
MAG.T12.45_00380	710696.Intca_1969	8.3e-86	323.6	Intrasporangiaceae	plsC		2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GJ6V@201174,4FEIG@85021,COG0204@1,COG0204@2	NA|NA|NA	I	1-acyl-sn-glycerol-3-phosphate acyltransferase
MAG.T12.45_00381	1236902.ANAS01000015_gene578	2.5e-190	671.8	Streptosporangiales	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626		R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147				Bacteria	2GM13@201174,4EFI5@85012,COG0554@1,COG0554@2	NA|NA|NA	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAG.T12.45_00383	935839.JAGJ01000012_gene2980	1.7e-76	292.4	Promicromonosporaceae	hutH		4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZW@201174,4F58H@85017,COG2986@1,COG2986@2	NA|NA|NA	E	Aromatic amino acid lyase
MAG.T12.45_00384	1192034.CAP_2819	1.4e-24	120.6	Myxococcales													Bacteria	1NAQM@1224,2WNXU@28221,2YVQF@29,42RR6@68525,COG1946@1,COG1946@2	NA|NA|NA	I	Thioesterase-like superfamily
MAG.T12.45_00385	644283.Micau_1166	1.2e-260	905.6	Micromonosporales	hutU		4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000				Bacteria	2GP10@201174,4D9Y2@85008,COG2987@1,COG2987@2	NA|NA|NA	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MAG.T12.45_00386	644283.Micau_1163	1.4e-143	516.2	Micromonosporales	hutI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJH4@201174,4DBJ2@85008,COG1228@1,COG1228@2	NA|NA|NA	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MAG.T12.45_00387	1120960.ATXG01000004_gene1805	3.2e-87	328.6	Microbacteriaceae	hutG		3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJA6@201174,4FKS9@85023,COG0010@1,COG0010@2	NA|NA|NA	E	Arginase family
MAG.T12.45_00388	1304865.JAGF01000001_gene497	4.6e-72	278.1	Actinobacteria													Bacteria	2GQC1@201174,COG2267@1,COG2267@2	NA|NA|NA	I	Alpha beta hydrolase
MAG.T12.45_00389	312284.A20C1_11546	4.9e-46	191.0	unclassified Actinobacteria (class)													Bacteria	2HP5X@201174,3UXNT@52018,COG1309@1,COG1309@2	NA|NA|NA	K	WHG domain
MAG.T12.45_00390	796942.HMPREF9623_01830	2.7e-70	272.3	Clostridia													Bacteria	1TSAT@1239,24A6W@186801,COG0535@1,COG0535@2	NA|NA|NA	S	radical SAM domain protein
MAG.T12.45_00392	1211815.CBYP010000051_gene683	3.3e-20	105.5	Frankiales				ko:K03265	ko03015,map03015				ko00000,ko00001,ko03012,ko03019				Bacteria	2IFQH@201174,4ET50@85013,COG1503@1,COG1503@2	NA|NA|NA	J	translation release factor activity
MAG.T12.45_00393	44060.JODL01000025_gene142	3.7e-39	168.3	Actinobacteria													Bacteria	2GNIP@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00394	909613.UO65_3763	2.2e-264	918.3	Pseudonocardiales	fadB		1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ50@201174,4E0TU@85010,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase
MAG.T12.45_00395	909613.UO65_3764	3.1e-175	621.3	Pseudonocardiales			2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJAC@201174,4DXDP@85010,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T12.45_00396	1278078.G419_22134	4.4e-99	367.9	Nocardiaceae			3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2			Bacteria	2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2	NA|NA|NA	P	PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein
MAG.T12.45_00398	471857.Svir_27290	1.9e-12	78.6	Pseudonocardiales	MA20_25230			ko:K09131					ko00000				Bacteria	2GQSC@201174,4E6KR@85010,COG1872@1,COG1872@2	NA|NA|NA	EGP	Belongs to the UPF0235 family
MAG.T12.45_00399	1116232.AHBF01000005_gene1545	2.5e-35	155.2	Actinobacteria	dksA			ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	2GJBE@201174,COG1734@1,COG1734@2	NA|NA|NA	T	Transcriptional regulator, TraR DksA family
MAG.T12.45_00400	298654.FraEuI1c_2385	1.5e-36	159.5	Frankiales	lspA		3.4.23.36	ko:K03101	ko03060,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	2GKRX@201174,4ET0T@85013,COG0597@1,COG0597@2	NA|NA|NA	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MAG.T12.45_00402	1463856.JOHY01000007_gene716	1.5e-67	262.7	Actinobacteria	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360		ko:K13288	ko03008,map03008				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GJR7@201174,COG1949@1,COG1949@2	NA|NA|NA	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MAG.T12.45_00403	404589.Anae109_2437	7.9e-13	80.5	Myxococcales				ko:K04767,ko:K07168,ko:K07182					ko00000				Bacteria	1N0EB@1224,2WRIB@28221,2YVSI@29,42W96@68525,COG0517@1,COG0517@2	NA|NA|NA	S	CBS domain
MAG.T12.45_00404	1125863.JAFN01000001_gene2799	8.3e-35	153.3	Deltaproteobacteria	tesC	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575		ko:K07107,ko:K12500					ko00000,ko01000,ko01004				Bacteria	1REIH@1224,2WQAZ@28221,42UZ3@68525,COG0824@1,COG0824@2	NA|NA|NA	S	Thioesterase-like superfamily
MAG.T12.45_00405	2002.JOEQ01000005_gene3672	1.7e-184	652.9	Streptosporangiales													Bacteria	2I3HX@201174,4EHKS@85012,COG0421@1,COG0421@2	NA|NA|NA	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MAG.T12.45_00406	1237500.ANBA01000033_gene4471	7.2e-145	520.8	Streptosporangiales	ada		3.2.2.21	ko:K13529,ko:K15051	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	2GITG@201174,4EGE3@85012,COG0122@1,COG0122@2,COG2169@1,COG2169@2	NA|NA|NA	FL	AlkA N-terminal domain
MAG.T12.45_00407	1192759.AKIB01000096_gene1609	1.5e-37	162.9	Sphingomonadales	ogt		1.17.99.6,2.1.1.63	ko:K00567,ko:K18979					ko00000,ko01000,ko03016,ko03400				Bacteria	1N2YQ@1224,2KD23@204457,2TRRN@28211,COG0350@1,COG0350@2	NA|NA|NA	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MAG.T12.45_00409	1121017.AUFG01000013_gene1927	6.9e-188	664.1	Intrasporangiaceae	feoB			ko:K04759					ko00000,ko02000	9.A.8.1			Bacteria	2GTV2@201174,4FIUH@85021,COG0370@1,COG0370@2	NA|NA|NA	P	Ferrous iron transport protein B C terminus
MAG.T12.45_00411	37919.EP51_17595	3.5e-183	648.7	Nocardiaceae													Bacteria	2GJPU@201174,4FTWD@85025,COG1807@1,COG1807@2	NA|NA|NA	M	Dolichyl-phosphate-mannose-protein mannosyltransferase
MAG.T12.45_00412	675635.Psed_5033	2.5e-144	518.8	Pseudonocardiales				ko:K07015					ko00000				Bacteria	2GJTE@201174,4DYC7@85010,COG1215@1,COG1215@2,COG2246@1,COG2246@2	NA|NA|NA	M	GtrA-like protein
MAG.T12.45_00413	479435.Kfla_2948	7.4e-60	237.3	Propionibacteriales													Bacteria	2B34Q@1,2I2K1@201174,2ZK49@2,4DX2H@85009	NA|NA|NA		
MAG.T12.45_00415	471853.Bcav_0717	3.7e-18	98.6	Actinobacteria													Bacteria	2GJRY@201174,COG2197@1,COG2197@2	NA|NA|NA	T	response regulator
MAG.T12.45_00416	743718.Isova_2354	2.9e-44	185.3	Promicromonosporaceae	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05808					ko00000,ko03009				Bacteria	2GMYF@201174,4F3CD@85017,COG1544@1,COG1544@2	NA|NA|NA	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MAG.T12.45_00417	1211815.CBYP010000043_gene3449	4e-29	135.2	Frankiales	ctsW			ko:K02242		M00429			ko00000,ko00002,ko02044				Bacteria	2I9PA@201174,4ET02@85013,COG1040@1,COG1040@2	NA|NA|NA	S	phosphoribosyltransferase
MAG.T12.45_00418	931627.MycrhDRAFT_0079	1e-32	147.9	Mycobacteriaceae	CP_0034			ko:K02417,ko:K02519	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044,ko03012,ko03029	3.A.6.2,3.A.6.3			Bacteria	2330W@1762,2GKJ7@201174,COG5180@1,COG5180@2	NA|NA|NA	A	pathogenesis
MAG.T12.45_00419	1089545.KB913037_gene5605	3.1e-38	165.2	Pseudonocardiales													Bacteria	2CT9V@1,2GKR6@201174,32SSX@2,4E4EE@85010	NA|NA|NA	S	Domain of unknown function (DUF4129)
MAG.T12.45_00420	1123320.KB889749_gene4532	1.2e-54	220.7	Actinobacteria		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	29B69@1,2GKQW@201174,2ZY4N@2	NA|NA|NA		
MAG.T12.45_00421	1449346.JQMO01000003_gene5361	2.8e-134	485.0	Kitasatospora	moxR2			ko:K03924					ko00000,ko01000				Bacteria	2GK07@201174,2M108@2063,COG0714@1,COG0714@2	NA|NA|NA	S	ATPase family associated with various cellular activities (AAA)
MAG.T12.45_00422	208444.JNYY01000029_gene1055	1.8e-115	422.9	Pseudonocardiales													Bacteria	2GK9A@201174,4DXK9@85010,COG1721@1,COG1721@2	NA|NA|NA	S	Protein of unknown function DUF58
MAG.T12.45_00423	1122611.KB903946_gene708	1.8e-96	359.4	Streptosporangiales				ko:K06384					ko00000				Bacteria	2GJTG@201174,4EH4Y@85012,COG1300@1,COG1300@2	NA|NA|NA	S	Stage II sporulation protein M
MAG.T12.45_00424	1125971.ASJB01000080_gene7656	1.3e-51	210.3	Pseudonocardiales													Bacteria	2H4MP@201174,4E2SC@85010,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T12.45_00425	269800.Tfu_2505	2.7e-226	791.2	Streptosporangiales	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147				Bacteria	2GK2Q@201174,4EIAX@85012,COG0499@1,COG0499@2	NA|NA|NA	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MAG.T12.45_00426	134676.ACPL_1062	1.7e-91	342.8	Micromonosporales	cat												Bacteria	2GKSG@201174,4DAPD@85008,COG0053@1,COG0053@2	NA|NA|NA	P	cation diffusion facilitator family transporter
MAG.T12.45_00427	298654.FraEuI1c_6060	2.8e-13	80.9	Frankiales	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2HUT6@201174,4ETHY@85013,COG2835@1,COG2835@2	NA|NA|NA	S	Trm112p-like protein
MAG.T12.45_00428	471852.Tcur_4063	2e-170	605.5	Streptosporangiales	manB	GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	Bacteria	2GJQA@201174,4EGWS@85012,COG1109@1,COG1109@2	NA|NA|NA	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain
MAG.T12.45_00429	1380346.JNIH01000014_gene897	1.3e-39	169.1	Actinobacteria													Bacteria	2C7XW@1,2IQ5R@201174,32RR4@2	NA|NA|NA	S	Protein of unknown function (DUF3499)
MAG.T12.45_00430	1120950.KB892759_gene6287	4.4e-33	149.4	Propionibacteriales	dedD			ko:K02520,ko:K03749,ko:K06204,ko:K16291	ko02026,map02026				ko00000,ko00001,ko01002,ko01011,ko03000,ko03009,ko03012,ko03021,ko03029				Bacteria	2HC8A@201174,4DRQT@85009,COG3147@1,COG3147@2	NA|NA|NA	S	Non-essential cell division protein that could be required for efficient cell constriction
MAG.T12.45_00431	1463864.JOGO01000058_gene3814	5.9e-90	339.3	Actinobacteria													Bacteria	2GIUN@201174,COG1216@1,COG1216@2	NA|NA|NA	M	PFAM Glycosyl transferase family 2
MAG.T12.45_00432	1122622.ATWJ01000015_gene620	4e-32	143.7	Intrasporangiaceae	whiB2			ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQ4Q@201174,32RUK@2,4FHAS@85021	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T12.45_00434	1449355.JQNR01000005_gene2189	1.7e-67	263.1	Actinobacteria			3.2.2.21	ko:K01247	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GP69@201174,COG0122@1,COG0122@2	NA|NA|NA	L	3-methyladenine DNA glycosylase
MAG.T12.45_00435	1079986.JH164840_gene4710	2e-117	429.1	Actinobacteria	manC		2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKTE@201174,COG1208@1,COG1208@2	NA|NA|NA	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits
MAG.T12.45_00437	1123320.KB889719_gene7426	7.6e-14	83.6	Actinobacteria													Bacteria	2GIX4@201174,COG0318@1,COG0318@2	NA|NA|NA	IQ	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MAG.T12.45_00438	1306174.JODP01000001_gene4657	1.6e-60	241.5	Actinobacteria													Bacteria	2GNDB@201174,COG4102@1,COG4102@2,COG5479@1,COG5479@2	NA|NA|NA	M	N-acetylmuramoyl-L-alanine amidase
MAG.T12.45_00439	266940.Krad_0030	1.6e-74	287.0	Actinobacteria													Bacteria	2GJM3@201174,COG1316@1,COG1316@2	NA|NA|NA	K	cell envelope-related transcriptional attenuator
MAG.T12.45_00440	1348663.KCH_29210	1.2e-98	366.3	Kitasatospora			2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650		R00410	RC00014	ko00000,ko00001,ko01000				Bacteria	2GK61@201174,2M482@2063,COG1788@1,COG1788@2	NA|NA|NA	I	Coenzyme A transferase
MAG.T12.45_00441	1996.JOFO01000004_gene3448	3.3e-91	341.3	Streptosporangiales	scoB		2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650		R00410	RC00014	ko00000,ko00001,ko01000				Bacteria	2GKV9@201174,4EI8M@85012,COG2057@1,COG2057@2	NA|NA|NA	I	Coenzyme A transferase
MAG.T12.45_00442	110663.KI911558_gene1353	6.7e-10	70.9	Synechococcus	ste14												Bacteria	1G67D@1117,1H0KJ@1129,COG2020@1,COG2020@2	NA|NA|NA	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family
MAG.T12.45_00443	909613.UO65_5851	4.1e-96	358.6	Actinobacteria													Bacteria	2H6EP@201174,COG1887@1,COG1887@2	NA|NA|NA	M	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAG.T12.45_00444	935839.JAGJ01000002_gene821	2e-78	298.9	Actinobacteria	phnW		2.6.1.37,2.7.7.74,2.7.8.12	ko:K03430,ko:K07281,ko:K09809	ko00440,ko00562,ko01100,ko01120,map00440,map00562,map01100,map01120		R04152,R09669	RC00002,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007				Bacteria	2GN1Y@201174,COG1213@1,COG1213@2	NA|NA|NA	M	transferase
MAG.T12.45_00445	1120959.ATXF01000010_gene75	5.4e-100	370.9	Microbacteriaceae		GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K07011					ko00000				Bacteria	2GK2D@201174,4FMHT@85023,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T12.45_00446	1001240.GY21_15460	5.5e-21	107.1	Microbacteriaceae													Bacteria	2GN3C@201174,4FKEI@85023,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T12.45_00447	675635.Psed_2013	4.5e-23	113.6	Pseudonocardiales	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02968	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ73@201174,4E5HA@85010,COG0268@1,COG0268@2	NA|NA|NA	J	Binds directly to 16S ribosomal RNA
MAG.T12.45_00448	2002.JOEQ01000001_gene4724	6.2e-40	171.8	Streptosporangiales	holA		2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GNMZ@201174,4EHWU@85012,COG1466@1,COG1466@2	NA|NA|NA	L	DNA polymerase III, delta subunit
MAG.T12.45_00449	285535.JOEY01000013_gene4625	1e-25	123.6	Actinobacteria	comEC			ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	2GJGR@201174,COG0658@1,COG0658@2,COG2333@1,COG2333@2	NA|NA|NA	L	ComEC Rec2-related protein
MAG.T12.45_00457	1463934.JOCF01000060_gene3408	1.4e-13	84.0	Actinobacteria													Bacteria	2EGYK@1,2GRY2@201174,3493T@2	NA|NA|NA		
MAG.T12.45_00459	234267.Acid_3078	1.5e-188	666.0	Bacteria													Bacteria	COG1960@1,COG1960@2	NA|NA|NA	I	acyl-CoA dehydrogenase activity
MAG.T12.45_00460	1122611.KB903985_gene3663	7.9e-133	480.7	Streptosporangiales			1.13.12.16	ko:K00459	ko00910,map00910		R00025	RC02541,RC02759	ko00000,ko00001,ko01000				Bacteria	2I93H@201174,4EIEF@85012,COG2070@1,COG2070@2	NA|NA|NA	S	2-Nitropropane dioxygenase
MAG.T12.45_00461	1454010.JEOE01000011_gene2396	1.3e-88	334.3	Actinobacteria													Bacteria	2IBWT@201174,COG4425@1,COG4425@2	NA|NA|NA	S	Alpha/beta-hydrolase family
MAG.T12.45_00463	290397.Adeh_2189	1.4e-36	160.2	Myxococcales													Bacteria	1RAAG@1224,2WNJI@28221,2Z2RH@29,42RIX@68525,COG2030@1,COG2030@2	NA|NA|NA	I	MaoC like domain
MAG.T12.45_00465	358823.DF19_41840	3.4e-17	95.1	Actinobacteria	ssb1			ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	2IGBM@201174,COG0629@1,COG0629@2	NA|NA|NA	L	Single-strand binding protein family
MAG.T12.45_00466	864051.BurJ1DRAFT_4671	4.1e-103	381.7	unclassified Burkholderiales	dapE1												Bacteria	1KKBA@119065,1MW20@1224,2VIT5@28216,COG0624@1,COG0624@2	NA|NA|NA	E	Peptidase dimerisation domain
MAG.T12.45_00467	987059.RBXJA2T_02912	8.2e-148	530.0	unclassified Burkholderiales		GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100		R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	1KJBW@119065,1MXCH@1224,2VHBC@28216,COG3178@1,COG3178@2	NA|NA|NA	S	Phosphotransferase
MAG.T12.45_00471	1385519.N801_08145	6.2e-93	347.4	Intrasporangiaceae				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJN6@201174,4FF61@85021,COG1136@1,COG1136@2	NA|NA|NA	V	ABC transporter, ATP-binding protein
MAG.T12.45_00472	1120936.KB907219_gene3210	1e-40	173.7	Streptosporangiales	hisE												Bacteria	2GJNG@201174,4EITJ@85012,COG0637@1,COG0637@2	NA|NA|NA	S	Haloacid dehalogenase-like hydrolase
MAG.T12.45_00474	465515.Mlut_16430	2.4e-30	139.8	Micrococcaceae	fthC		6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100		R02301	RC00183	ko00000,ko00001,ko01000				Bacteria	1W9K2@1268,2IKWR@201174,COG0212@1,COG0212@2	NA|NA|NA	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MAG.T12.45_00475	350058.Mvan_4835	2.6e-18	98.2	Mycobacteriaceae	fmdB												Bacteria	23AJP@1762,2IQHE@201174,COG2331@1,COG2331@2	NA|NA|NA	S	regulatory protein, FmdB family
MAG.T12.45_00476	983917.RGE_33140	4e-63	247.7	unclassified Burkholderiales													Bacteria	1KIU0@119065,1MY2Z@1224,2VIT4@28216,COG0745@1,COG0745@2	NA|NA|NA	K	phosphate regulon transcriptional regulatory protein PhoB
MAG.T12.45_00477	987059.RBXJA2T_09727	1.8e-93	349.0	unclassified Burkholderiales	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186		ko:K02039					ko00000				Bacteria	1KIW3@119065,1MUMI@1224,2VI2C@28216,COG0704@1,COG0704@2	NA|NA|NA	P	Plays a role in the regulation of phosphate uptake
MAG.T12.45_00478	1095772.CAHH01000068_gene347	3.8e-102	377.9	Actinobacteria	pstB		3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Bacteria	2GJQ3@201174,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MAG.T12.45_00479	1172179.AUKV01000029_gene7734	1.9e-91	342.8	Actinobacteria	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217	Bacteria	2I2F2@201174,COG0581@1,COG0581@2	NA|NA|NA	P	phosphate transport system permease
MAG.T12.45_00480	1957.JODX01000009_gene2682	7.5e-95	354.0	Actinobacteria	pstC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iAF987.Gmet_2702,ic_1306.c4652	Bacteria	2GJDA@201174,COG0573@1,COG0573@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
MAG.T12.45_00481	44060.JODL01000005_gene651	1.9e-118	432.2	Actinobacteria	ppdK		2.7.3.13,2.7.9.1	ko:K01006,ko:K22424	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK73@201174,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	G	Belongs to the PEP-utilizing enzyme family
MAG.T12.45_00482	1123322.KB904724_gene2000	3.7e-131	474.9	Actinobacteria	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230		R01856	RC00017	ko00000,ko00001,ko01000				Bacteria	2GJ8F@201174,COG0232@1,COG0232@2	NA|NA|NA	F	Deoxyguanosinetriphosphate triphosphohydrolase-like protein
MAG.T12.45_00483	1123023.JIAI01000007_gene1976	5e-30	137.9	Pseudonocardiales													Bacteria	2I2NF@201174,4E2P9@85010,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
MAG.T12.45_00484	351607.Acel_0806	1.7e-183	649.4	Frankiales	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944		ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	2GJFX@201174,4ERCW@85013,COG0358@1,COG0358@2	NA|NA|NA	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MAG.T12.45_00485	469371.Tbis_1189	2e-19	102.4	Actinobacteria	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141		ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	2IR95@201174,COG0776@1,COG0776@2	NA|NA|NA	L	regulation of translation
MAG.T12.45_00486	1121933.AUHH01000022_gene2486	6.4e-24	118.6	Propionibacteriales			4.4.1.32	ko:K02289	ko00196,ko01100,map00196,map01100				ko00000,ko00001,ko00194,ko01000				Bacteria	2GITU@201174,4DVW4@85009,COG1413@1,COG1413@2	NA|NA|NA	C	HEAT repeats
MAG.T12.45_00487	1035308.AQYY01000002_gene584	1.8e-39	170.2	Peptococcaceae	nolA			ko:K19591		M00769			ko00000,ko00002,ko01504,ko03000				Bacteria	1V8GZ@1239,25M6J@186801,26621@186807,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T12.45_00490	1907.SGLAU_10165	1.4e-53	216.9	Actinobacteria													Bacteria	2GKT0@201174,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00493	1003195.SCAT_3393	4.2e-61	241.5	Actinobacteria	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02493,ko:K02527,ko:K03439	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763,R10806	RC00003,RC00009,RC00077,RC00247,RC03279	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016		GT30		Bacteria	2GJ8R@201174,COG0220@1,COG0220@2	NA|NA|NA	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MAG.T12.45_00494	1385520.N802_05395	2.1e-64	252.3	Intrasporangiaceae			1.5.1.40	ko:K06988					ko00000,ko01000				Bacteria	2GMN3@201174,4FJWG@85021,COG2085@1,COG2085@2	NA|NA|NA	S	NADP oxidoreductase
MAG.T12.45_00495	298654.FraEuI1c_5203	5.3e-125	454.1	Frankiales	yhhW_2			ko:K06911					ko00000				Bacteria	2GIY9@201174,4ES53@85013,COG1741@1,COG1741@2	NA|NA|NA	S	Belongs to the pirin family
MAG.T12.45_00496	1123322.KB904701_gene313	3.7e-107	394.8	Actinobacteria	mutY			ko:K03575	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJD9@201174,COG1194@1,COG1194@2	NA|NA|NA	L	adenine glycosylase
MAG.T12.45_00499	1123023.JIAI01000004_gene7846	2.7e-65	255.4	Bacteria													Bacteria	COG1808@1,COG1808@2	NA|NA|NA	S	Domain of unknown function (DUF389)
MAG.T12.45_00500	1227261.HMPREF0043_00810	3.9e-07	60.8	Actinobacteria													Bacteria	2GITW@201174,4D39J@85005,COG1167@1,COG1167@2	NA|NA|NA	EK	Aminotransferase, class I II
MAG.T12.45_00502	1035308.AQYY01000001_gene3069	1.4e-123	449.9	Clostridia	hemG		1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000				Bacteria	1TQ6W@1239,24IHQ@186801,COG1232@1,COG1232@2	NA|NA|NA	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MAG.T12.45_00503	446471.Xcel_3125	2.6e-136	491.9	Actinobacteria	pqqE			ko:K22227					ko00000				Bacteria	2GNSY@201174,COG0535@1,COG0535@2	NA|NA|NA	C	Radical SAM
MAG.T12.45_00504	266940.Krad_1273	8.8e-11	73.2	Actinobacteria													Bacteria	2E3JG@1,2GU6T@201174,32YHV@2	NA|NA|NA		
MAG.T12.45_00505	479435.Kfla_5917	3.8e-154	551.6	Propionibacteriales	yjcD	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40			Bacteria	2GKYD@201174,4DNIA@85009,COG2252@1,COG2252@2	NA|NA|NA	S	Permease family
MAG.T12.45_00506	134676.ACPL_5559	2.3e-28	134.0	Actinobacteria													Bacteria	2IR52@201174,COG1525@1,COG1525@2	NA|NA|NA	L	Lamin Tail Domain
MAG.T12.45_00507	1121272.KB903255_gene5793	1.6e-67	263.1	Micromonosporales	pac			ko:K07184					ko00000				Bacteria	2I2N7@201174,4DBJV@85008,COG1938@1,COG1938@2	NA|NA|NA	S	PAC2 family
MAG.T12.45_00509	1235801.C822_02013	5.5e-20	104.0	Lactobacillaceae	mscL	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K03282					ko00000,ko02000	1.A.22.1			Bacteria	1VA14@1239,3F6YZ@33958,4HKIA@91061,COG1970@1,COG1970@2	NA|NA|NA	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MAG.T12.45_00510	1077972.ARGLB_085_02840	2.5e-15	89.0	Micrococcaceae	cpaB			ko:K02279					ko00000,ko02035,ko02044				Bacteria	1WA6R@1268,2GQJH@201174,COG3745@1,COG3745@2	NA|NA|NA	U	SAF
MAG.T12.45_00511	1504319.GM45_0760	1.7e-102	379.4	unclassified Actinobacteria (class)	qcrA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03890,ko:K15878	ko00190,ko01100,map00190,map01100	M00151			ko00000,ko00001,ko00002			iAF987.Gmet_0538	Bacteria	2GIX6@201174,3UWCF@52018,COG0723@1,COG0723@2	NA|NA|NA	C	Rieske [2Fe-2S] domain
MAG.T12.45_00512	1504319.GM45_0765	1.2e-71	276.6	unclassified Actinobacteria (class)	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K00406,ko:K03889	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00151,M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	2GKUB@201174,3UWHN@52018,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T12.45_00513	1214101.BN159_6284	3.2e-70	271.6	Actinobacteria	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6		iJN678.ctaE	Bacteria	2GKK8@201174,COG1845@1,COG1845@2	NA|NA|NA	C	cytochrome c oxidase, subunit III
MAG.T12.45_00514	196162.Noca_3132	6.1e-46	190.3	Propionibacteriales		GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944											Bacteria	2II71@201174,4DQR3@85009,COG0784@1,COG0784@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T12.45_00515	469371.Tbis_1298	5.1e-92	344.7	Pseudonocardiales	trpD		2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM4G@201174,4DYFX@85010,COG0547@1,COG0547@2	NA|NA|NA	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MAG.T12.45_00517	351607.Acel_0958	2.8e-24	118.2	Frankiales	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2D9MJ@1,2IFFM@201174,32TTI@2,4ETA5@85013	NA|NA|NA	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family
MAG.T12.45_00518	446469.Sked_15640	1.5e-123	449.1	Actinobacteria	ctaD	GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6			Bacteria	2GJHX@201174,COG0843@1,COG0843@2	NA|NA|NA	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MAG.T12.45_00519	1155718.KB891889_gene6846	1.3e-203	716.1	Actinobacteria	cimA		2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GKYT@201174,COG0119@1,COG0119@2	NA|NA|NA	E	Belongs to the alpha-IPM synthase homocitrate synthase family
MAG.T12.45_00520	981369.JQMJ01000004_gene5700	3.4e-82	311.6	Streptacidiphilus	fahA												Bacteria	2GN2G@201174,2NF0A@228398,COG0179@1,COG0179@2	NA|NA|NA	Q	Domain of unknown function (DUF2437)
MAG.T12.45_00521	1504319.GM45_4290	4.5e-187	661.0	unclassified Actinobacteria (class)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iNJ661.Rv2992c	Bacteria	2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAG.T12.45_00522	272844.PAB2253	2.7e-33	149.4	Thermococci	pgk2			ko:K05715			R02664	RC00002,RC00017	ko00000,ko01000				Archaea	242Y8@183968,2XVZC@28890,COG2074@1,arCOG01967@2157	NA|NA|NA	F	2-phosphoglycerate kinase
MAG.T12.45_00525	1134445.AJJM01000058_gene2331	1.1e-95	356.3	Actinobacteria	ltbR												Bacteria	2GKB0@201174,COG1414@1,COG1414@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00526	1003195.SCAT_4386	4e-214	750.7	Actinobacteria	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531	Bacteria	2GKT7@201174,COG0065@1,COG0065@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T12.45_00527	862751.SACTE_4123	1.2e-140	506.1	Actinobacteria	bhbA		5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM65@201174,COG1884@1,COG1884@2	NA|NA|NA	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAG.T12.45_00528	1157638.KB892158_gene5453	4.1e-123	448.0	Actinobacteria	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340		R01560,R02556	RC00477	ko00000,ko00001,ko01000			iNJ661.Rv3313c	Bacteria	2GJ6I@201174,COG1816@1,COG1816@2	NA|NA|NA	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MAG.T12.45_00529	1278078.G419_15843	2.2e-43	182.6	Nocardiaceae	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030		R01066	RC00436,RC00437	ko00000,ko00001,ko01000			iSB619.SA_RS00835	Bacteria	2GJIR@201174,4FX02@85025,COG0274@1,COG0274@2	NA|NA|NA	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MAG.T12.45_00530	585531.HMPREF0063_11453	1e-89	336.7	Propionibacteriales	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	2GKEI@201174,4DMXP@85009,COG0005@1,COG0005@2	NA|NA|NA	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MAG.T12.45_00531	471852.Tcur_4181	2.4e-47	194.9	Streptosporangiales	ykqA												Bacteria	2GJM9@201174,4EIZE@85012,COG3703@1,COG3703@2	NA|NA|NA	P	AIG2-like family
MAG.T12.45_00532	1136417.AZWE01000057_gene2016	9.7e-12	78.2	Micromonosporales													Bacteria	2GKF3@201174,4D9DE@85008,COG0577@1,COG0577@2	NA|NA|NA	V	FtsX-like permease family
MAG.T12.45_00533	318424.EU78_00435	5.1e-34	149.8	Mycobacteriaceae													Bacteria	23F1P@1762,2GM8F@201174,COG3328@1,COG3328@2	NA|NA|NA	L	Transposase
MAG.T12.45_00534	101510.RHA1_ro00462	1.1e-99	370.2	Nocardiaceae													Bacteria	2HW2F@201174,4G8FB@85025,COG3328@1,COG3328@2,COG3666@1,COG3666@2	NA|NA|NA	L	Transposase, Mutator family
MAG.T12.45_00535	1033730.CAHG01000006_gene1155	4.9e-18	96.7	Propionibacteriales				ko:K07213	ko04978,map04978				ko00000,ko00001				Bacteria	2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2	NA|NA|NA	P	Heavy-metal-associated domain
MAG.T12.45_00537	153948.NAL212_0227	1.1e-30	139.8	Nitrosomonadales													Bacteria	1PE85@1224,2W92M@28216,373FB@32003,COG0500@1,COG2226@2	NA|NA|NA	Q	Mycolic acid cyclopropane synthetase
MAG.T12.45_00538	1211815.CBYP010000062_gene3157	0.0	1112.8	Frankiales			3.6.3.4	ko:K01533			R00086	RC00002	ko00000,ko01000	3.A.3.5			Bacteria	2GIRF@201174,4ERFZ@85013,COG2217@1,COG2217@2	NA|NA|NA	P	E1-E2 ATPase
MAG.T12.45_00539	1122998.AUHZ01000010_gene1513	1.2e-10	72.4	Propionibacteriales	csoR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K21600					ko00000,ko03000				Bacteria	2IQAC@201174,4DRND@85009,COG1937@1,COG1937@2	NA|NA|NA	S	Metal-sensitive transcriptional repressor
MAG.T12.45_00541	196162.Noca_3785	6.6e-55	220.7	Propionibacteriales			1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214				ko00000,ko00001,ko01000,ko01002,ko04147				Bacteria	2IGFI@201174,4DRG7@85009,COG1225@1,COG1225@2	NA|NA|NA	O	Redoxin
MAG.T12.45_00542	1122609.AUGT01000027_gene2723	9.8e-114	416.8	Propionibacteriales													Bacteria	2GMXW@201174,4DTAU@85009,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein transmembrane region
MAG.T12.45_00543	446466.Cfla_0354	3.4e-17	94.4	Bacteria													Bacteria	COG0695@1,COG0695@2	NA|NA|NA	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MAG.T12.45_00544	1240349.ANGC01000011_gene328	2.3e-55	222.2	Nocardiaceae													Bacteria	2GIX7@201174,4G094@85025,COG5002@1,COG5002@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T12.45_00545	644283.Micau_0969	9.7e-76	290.0	Micromonosporales	lys1												Bacteria	2GMQ1@201174,4DA5G@85008,COG1748@1,COG1748@2	NA|NA|NA	E	Saccharopine dehydrogenase C-terminal domain
MAG.T12.45_00546	521045.Kole_0725	1.9e-53	216.9	Thermotogae	hemN1												Bacteria	2GDT0@200918,COG0635@1,COG0635@2	NA|NA|NA	C	Elongator protein 3, MiaB family, Radical SAM
MAG.T12.45_00547	1380347.JNII01000005_gene3136	2.1e-180	638.6	Frankiales	gabT		2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GIS9@201174,4ERVR@85013,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T12.45_00549	35754.JNYJ01000029_gene9520	1.2e-48	199.5	Micromonosporales	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1294,iSB619.SA_RS06610	Bacteria	2GIX9@201174,4D8CZ@85008,COG0460@1,COG0460@2	NA|NA|NA	E	homoserine dehydrogenase
MAG.T12.45_00550	1463920.JOGB01000028_gene5208	5.6e-139	500.7	Actinobacteria	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250	Bacteria	2GJ5F@201174,COG0498@1,COG0498@2	NA|NA|NA	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAG.T12.45_00551	593907.Celgi_2478	3.7e-67	261.9	Cellulomonadaceae	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620	Bacteria	2GKIW@201174,4F0RU@85016,COG0083@1,COG0083@2	NA|NA|NA	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MAG.T12.45_00552	680646.RMDY18_13030	1e-06	61.2	Bacteria													Bacteria	28NAX@1,2ZBEI@2	NA|NA|NA		
MAG.T12.45_00553	356851.JOAN01000011_gene5380	1.3e-15	89.4	Micromonosporales	sod22												Bacteria	2GKCK@201174,4DAWY@85008,COG0025@1,COG0025@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T12.45_00554	1246995.AFR_23530	1e-53	216.1	Micromonosporales													Bacteria	2IM3K@201174,4DEGD@85008,COG0517@1,COG0517@2	NA|NA|NA	S	CBS domain
MAG.T12.45_00556	28444.JODQ01000004_gene6201	6.2e-37	161.4	Streptosporangiales	ubiA												Bacteria	2GJT3@201174,4ENNX@85012,COG0382@1,COG0382@2	NA|NA|NA	H	UbiA prenyltransferase family
MAG.T12.45_00557	105425.BBPL01000030_gene4521	7.7e-90	337.4	Streptacidiphilus	srsC												Bacteria	2GM2M@201174,2NGSA@228398,COG0644@1,COG0644@2	NA|NA|NA	C	FAD dependent oxidoreductase
MAG.T12.45_00558	67281.JNZZ01000019_gene123	3.3e-49	201.4	Streptomyces griseus group	ypbQ			ko:K16168					ko00000,ko01008				Bacteria	2IG52@201174,41AR5@629295,COG1755@1,COG1755@2	NA|NA|NA	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family
MAG.T12.45_00559	1463857.JOFZ01000004_gene2858	1.8e-118	432.6	Actinobacteria	bcsA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576		ko:K16167					ko00000,ko01008				Bacteria	2GV0U@201174,COG3424@1,COG3424@2	NA|NA|NA	Q	synthase
MAG.T12.45_00560	1068978.AMETH_3959	6.6e-108	397.1	Pseudonocardiales	egtC		3.5.1.118	ko:K07008	ko00340,map00340		R11021	RC00064,RC00090	ko00000,ko00001,ko01000				Bacteria	2GXCD@201174,4DX4A@85010,COG0121@1,COG0121@2	NA|NA|NA	S	Glutamine amidotransferases class-II
MAG.T12.45_00561	471852.Tcur_0543	1.9e-26	127.1	Streptosporangiales													Bacteria	2HCHA@201174,4EFUK@85012,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_00562	164757.Mjls_1687	1.4e-23	116.3	Mycobacteriaceae													Bacteria	23A9W@1762,2DZHZ@1,2IN6I@201174,31ZDG@2	NA|NA|NA		
MAG.T12.45_00563	1242864.D187_006584	1.1e-27	131.3	Proteobacteria	cmk		2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	1R72B@1224,COG0204@1,COG0204@2	NA|NA|NA	I	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
MAG.T12.45_00565	926569.ANT_03930	9.1e-66	256.9	Chloroflexi	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iJN746.PP_0840	Bacteria	2G6DI@200795,COG1045@1,COG1045@2	NA|NA|NA	E	TIGRFAM serine O-acetyltransferase
MAG.T12.45_00566	243233.MCA1022	1.7e-110	405.6	Methylococcales	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUBE@1224,1RN6J@1236,1XDN6@135618,COG0031@1,COG0031@2	NA|NA|NA	H	Belongs to the cysteine synthase cystathionine beta- synthase family
MAG.T12.45_00569	1380356.JNIK01000001_gene2193	6.2e-65	254.2	Frankiales													Bacteria	2GIS7@201174,4ESGF@85013,COG5011@1,COG5011@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2344)
MAG.T12.45_00570	471852.Tcur_1544	3.9e-300	1036.9	Streptosporangiales													Bacteria	2GJY1@201174,4EFRZ@85012,COG1032@1,COG1032@2	NA|NA|NA	C	Elongator protein 3, MiaB family, Radical SAM
MAG.T12.45_00571	1304865.JAGF01000001_gene2261	1.6e-192	678.7	Actinobacteria	bglH		3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1		Bacteria	2GJAF@201174,COG2723@1,COG2723@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 1 family
MAG.T12.45_00572	1484479.DI14_14505	9.3e-78	297.0	Bacilli													Bacteria	1UFDJ@1239,4HDIH@91061,COG0561@1,COG0561@2	NA|NA|NA	G	hydrolase
MAG.T12.45_00573	1172188.KB911821_gene1461	7.4e-188	664.1	Intrasporangiaceae													Bacteria	2GM2C@201174,4FIB5@85021,COG2898@1,COG2898@2	NA|NA|NA	S	Uncharacterised conserved protein (DUF2156)
MAG.T12.45_00574	1122622.ATWJ01000002_gene818	1.6e-24	119.0	Intrasporangiaceae				ko:K03972					ko00000				Bacteria	2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T12.45_00575	1184607.AUCHE_05_03520	2.5e-34	152.1	Actinobacteria	mauF		2.7.11.1	ko:K03466,ko:K06196,ko:K12132					ko00000,ko01000,ko01001,ko02000,ko03036	3.A.12,5.A.1.2			Bacteria	2IMP9@201174,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein
MAG.T12.45_00576	1121946.AUAX01000005_gene5377	1.2e-207	729.6	Micromonosporales	csdA		2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GP7W@201174,4DAKS@85008,COG0520@1,COG0520@2	NA|NA|NA	E	Aminotransferase class-V
MAG.T12.45_00578	66377.JOBH01000001_gene1096	8.9e-96	357.5	Actinobacteria	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12	ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03032				Bacteria	2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2	NA|NA|NA	GL	phosphoglycerate mutase
MAG.T12.45_00579	1120936.KB907211_gene211	1.7e-54	219.5	Streptosporangiales				ko:K07164					ko00000				Bacteria	2GP84@201174,4EH3Z@85012,COG1579@1,COG1579@2	NA|NA|NA	S	C4-type zinc ribbon domain
MAG.T12.45_00580	2074.JNYD01000014_gene7130	2.3e-114	419.1	Pseudonocardiales	yqfO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKHZ@201174,4DXZJ@85010,COG0327@1,COG0327@2	NA|NA|NA	S	PFAM NIF3 (NGG1p interacting factor 3)
MAG.T12.45_00582	1429046.RR21198_5847	5.6e-256	890.6	Nocardiaceae	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GJGX@201174,4FXK7@85025,COG1034@1,COG1034@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
MAG.T12.45_00583	1380354.JIAN01000005_gene1505	9.6e-54	217.2	Cellulomonadaceae	nuoF		1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GMMC@201174,4F0VX@85016,COG1894@1,COG1894@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MAG.T12.45_00584	471852.Tcur_4029	1.4e-18	98.6	Streptosporangiales			2.7.1.193	ko:K02803	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7			Bacteria	2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2	NA|NA|NA	G	phosphotransferase system, EIIB
MAG.T12.45_00585	1137269.AZWL01000012_gene2982	3.8e-115	421.8	Actinobacteria	nagE		2.7.1.193,2.7.1.199	ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	M00267,M00809	R02738,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9			Bacteria	2GKPM@201174,COG1263@1,COG1263@2	NA|NA|NA	G	Phosphotransferase System
MAG.T12.45_00586	1120950.KB892720_gene1909	1.8e-100	372.9	Propionibacteriales	nagA		3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130		R02059	RC00166,RC00300	ko00000,ko00001,ko01000			iNJ661.Rv3332	Bacteria	2GK1E@201174,4DPBF@85009,COG1820@1,COG1820@2	NA|NA|NA	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MAG.T12.45_00587	1254432.SCE1572_32985	2.5e-21	110.2	Proteobacteria													Bacteria	1N5ID@1224,COG3591@1,COG3591@2	NA|NA|NA	E	Belongs to the peptidase S1B family
MAG.T12.45_00588	67373.JOBF01000006_gene2459	2.4e-36	159.1	Actinobacteria													Bacteria	2GP92@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00589	65497.JODV01000007_gene534	7.5e-129	466.8	Pseudonocardiales	menB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000			iJN678.menB,iYL1228.KPN_02660	Bacteria	2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2	NA|NA|NA	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily
MAG.T12.45_00590	478801.Ksed_24140	1.6e-72	280.0	Dermacoccaceae	menC	GO:0008150,GO:0040007	4.2.1.113,5.1.1.20,5.1.1.3	ko:K01776,ko:K02549,ko:K19802	ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110	M00116	R00260,R04031,R10938	RC00302,RC01053,RC03309	ko00000,ko00001,ko00002,ko01000,ko01011			iNJ661.Rv0553,iSB619.SA_RS09080	Bacteria	1ZVR3@145357,2GJJR@201174,COG4948@1,COG4948@2	NA|NA|NA	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MAG.T12.45_00591	477641.MODMU_4977	3.2e-107	396.0	Frankiales	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS05085	Bacteria	2GMEB@201174,4ES4N@85013,COG1165@1,COG1165@2	NA|NA|NA	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MAG.T12.45_00592	1356852.N008_18865	2.9e-14	84.7	Cytophagia													Bacteria	47RW1@768503,4NUPH@976,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T12.45_00593	479435.Kfla_6301	1.6e-113	416.4	Propionibacteriales	menF		2.6.1.85,4.1.3.27,5.4.4.2	ko:K01657,ko:K02552,ko:K13950	ko00130,ko00400,ko00405,ko00790,ko01053,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00130,map00400,map00405,map00790,map01053,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00116	R00985,R00986,R01716,R01717	RC00010,RC00588,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKE8@201174,4DPGF@85009,COG1169@1,COG1169@2	NA|NA|NA	HQ	Isochorismate synthase
MAG.T12.45_00594	1137269.AZWL01000015_gene734	2.8e-94	351.7	Actinobacteria	ubiE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000			iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Bacteria	2GKFZ@201174,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MAG.T12.45_00595	452652.KSE_34280	2.3e-13	82.8	Kitasatospora													Bacteria	2HRC6@201174,2M45I@2063,COG1280@1,COG1280@2	NA|NA|NA	E	Sap, sulfolipid-1-addressing protein
MAG.T12.45_00596	1463887.KL589953_gene93	2.6e-66	258.8	Actinobacteria	pflA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564	1.97.1.4	ko:K04069			R04710		ko00000,ko01000			iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930	Bacteria	2GN2B@201174,COG1180@1,COG1180@2	NA|NA|NA	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MAG.T12.45_00597	479431.Namu_3208	0.0	1110.5	Actinobacteria	pflB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248	Bacteria	2GTTT@201174,COG1882@1,COG1882@2	NA|NA|NA	C	formate acetyltransferase
MAG.T12.45_00598	1120950.KB892779_gene972	3.3e-138	498.4	Propionibacteriales			1.3.99.38	ko:K21401					ko00000,ko01000				Bacteria	2GKGH@201174,4DPE1@85009,COG0644@1,COG0644@2	NA|NA|NA	C	FAD binding domain
MAG.T12.45_00599	436229.JOEH01000024_gene946	1.3e-50	205.7	Streptacidiphilus	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2IKWT@201174,2NJ30@228398,COG0838@1,COG0838@2	NA|NA|NA	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
MAG.T12.45_00600	1504319.GM45_4125	2.3e-85	321.6	unclassified Actinobacteria (class)	nuoB		1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GJXR@201174,3UWJQ@52018,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_00601	1003195.SCAT_3486	1.1e-90	339.7	Actinobacteria	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GIRH@201174,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_00602	1504319.GM45_4135	2e-194	685.3	unclassified Actinobacteria (class)	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GKEZ@201174,3UWKD@52018,COG0649@1,COG0649@2	NA|NA|NA	C	Belongs to the complex I 49 kDa subunit family
MAG.T12.45_00603	1504319.GM45_4140	1.6e-64	252.7	unclassified Actinobacteria (class)	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3,1.6.99.3	ko:K00334,ko:K00335,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6			Bacteria	2GKG0@201174,3UWSV@52018,COG1905@1,COG1905@2	NA|NA|NA	C	Thioredoxin-like [2Fe-2S] ferredoxin
MAG.T12.45_00605	234267.Acid_3077	9.8e-148	530.4	Acidobacteria				ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435		ko00000,ko00001,ko00002,ko01008				Bacteria	3Y347@57723,COG0304@1,COG0304@2,COG3321@1,COG3321@2,COG4221@1,COG4221@2	NA|NA|NA	Q	Acyl transferase domain
MAG.T12.45_00606	469383.Cwoe_4490	9.8e-30	137.1	Actinobacteria													Bacteria	2IR83@201174,COG2199@1,COG2199@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_00608	351607.Acel_0144	1.6e-74	286.6	Frankiales													Bacteria	2GJV7@201174,4ESVM@85013,COG1609@1,COG1609@2	NA|NA|NA	K	periplasmic binding protein LacI transcriptional regulator
MAG.T12.45_00609	710111.FraQA3DRAFT_4644	1.1e-20	106.3	Actinobacteria													Bacteria	2GJYB@201174,COG5485@1,COG5485@2	NA|NA|NA	S	SnoaL-like polyketide cyclase
MAG.T12.45_00610	1306406.ASHX01000001_gene4395	4.5e-124	451.1	Actinobacteria	yhhW_2			ko:K06911,ko:K06975					ko00000				Bacteria	2GM9P@201174,COG1741@1,COG1741@2,COG2388@1,COG2388@2	NA|NA|NA	S	Belongs to the pirin family
MAG.T12.45_00611	1172188.KB911825_gene3711	1.4e-38	166.0	Intrasporangiaceae													Bacteria	2IMM4@201174,4FGQX@85021,COG3832@1,COG3832@2	NA|NA|NA	S	Polyketide cyclase / dehydrase and lipid transport
MAG.T12.45_00612	1128421.JAGA01000002_gene1272	6.1e-30	139.0	unclassified Bacteria			2.7.7.65	ko:K21088	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	2NP1A@2323,COG5001@1,COG5001@2	NA|NA|NA	T	Putative diguanylate phosphodiesterase
MAG.T12.45_00613	314278.NB231_10523	3e-156	558.1	Gammaproteobacteria	fbp		3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000				Bacteria	1MXM7@1224,1SKUG@1236,COG1980@1,COG1980@2	NA|NA|NA	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)
MAG.T12.45_00614	1035308.AQYY01000002_gene263	1.8e-147	528.9	Clostridia				ko:K19265					ko00000,ko01000				Bacteria	1TRS0@1239,247RJ@186801,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T12.45_00615	68170.KL590486_gene9693	7.6e-45	187.6	Pseudonocardiales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2IING@201174,4E5D6@85010,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-2 family transporter protein
MAG.T12.45_00616	1227352.C173_04326	1.8e-61	243.0	Paenibacillaceae				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1TPBQ@1239,26VNN@186822,4HBXP@91061,COG1131@1,COG1131@2	NA|NA|NA	V	Bacitracin ABC transporter, ATP-binding protein
MAG.T12.45_00617	110319.CF8_1033	1.5e-18	99.0	Propionibacteriales	cbiL			ko:K02007,ko:K02009,ko:K16915	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23		iAF987.Gmet_2441	Bacteria	2GRUA@201174,4DS6B@85009,COG0310@1,COG0310@2	NA|NA|NA	P	PDGLE domain
MAG.T12.45_00618	1957.JODX01000015_gene1376	3e-53	215.3	Actinobacteria	cbiM			ko:K02007,ko:K16915	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GK2U@201174,COG0310@1,COG0310@2	NA|NA|NA	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MAG.T12.45_00620	935866.JAER01000040_gene512	1.2e-103	382.9	Propionibacteriales													Bacteria	2GJU1@201174,4DN4M@85009,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T12.45_00621	714083.JH370377_gene2640	3e-22	110.9	Microbacteriaceae													Bacteria	2DNW5@1,2IQ5T@201174,32ZGI@2,4FQ68@85023	NA|NA|NA	S	Rho termination factor, N-terminal domain
MAG.T12.45_00625	67352.JODS01000002_gene1441	2.5e-35	154.8	Actinobacteria	yjqA												Bacteria	2IHVS@201174,3172B@2,arCOG12631@1	NA|NA|NA	S	Bacterial PH domain
MAG.T12.45_00626	471853.Bcav_3179	7.6e-97	360.9	Actinobacteria													Bacteria	2H8PB@201174,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_00627	1032480.MLP_35440	4.3e-56	224.2	Propionibacteriales													Bacteria	2ISME@201174,4DV13@85009,COG4767@1,COG4767@2	NA|NA|NA	V	VanZ like family
MAG.T12.45_00628	367299.JOEE01000002_gene2522	2.1e-187	661.8	Intrasporangiaceae													Bacteria	2GWBV@201174,4FE3R@85021,COG1672@1,COG1672@2	NA|NA|NA	S	AAA ATPase domain
MAG.T12.45_00630	926564.KI911673_gene6308	4.8e-29	134.8	Actinobacteria													Bacteria	2HRC6@201174,COG1280@1,COG1280@2	NA|NA|NA	E	Sap, sulfolipid-1-addressing protein
MAG.T12.45_00634	1303692.SFUL_1738	6.9e-32	144.1	Actinobacteria		GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136											Bacteria	2AN86@1,2HWWU@201174,31D67@2	NA|NA|NA	S	membrane
MAG.T12.45_00635	469371.Tbis_1278	5.1e-139	500.7	Pseudonocardiales		GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008076,GO:0008150,GO:0008152,GO:0009117,GO:0009898,GO:0009987,GO:0010959,GO:0012505,GO:0012506,GO:0015459,GO:0016020,GO:0016021,GO:0016192,GO:0016247,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019637,GO:0019897,GO:0019898,GO:0030141,GO:0030424,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031234,GO:0031410,GO:0031982,GO:0032879,GO:0032880,GO:0032940,GO:0032991,GO:0033267,GO:0034641,GO:0034702,GO:0034703,GO:0034705,GO:0034762,GO:0034765,GO:0035579,GO:0036230,GO:0042119,GO:0042581,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043266,GO:0043269,GO:0043299,GO:0043312,GO:0044224,GO:0044237,GO:0044238,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046496,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051186,GO:0051234,GO:0055086,GO:0055114,GO:0060341,GO:0065007,GO:0065009,GO:0070820,GO:0070821,GO:0070995,GO:0071704,GO:0071944,GO:0072524,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098772,GO:0098796,GO:0098797,GO:0098805,GO:0099106,GO:0099503,GO:0120025,GO:0120038,GO:1901360,GO:1901379,GO:1901564,GO:1902495,GO:1903827,GO:1904062,GO:1990031,GO:1990351,GO:2000008											Bacteria	2GMT5@201174,4DX8D@85010,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T12.45_00636	981369.JQMJ01000004_gene2066	7.6e-16	89.4	Streptacidiphilus													Bacteria	2EFWK@1,2IQXQ@201174,2NK0Q@228398,339NW@2	NA|NA|NA		
MAG.T12.45_00637	1449355.JQNR01000003_gene515	1.1e-26	127.1	Actinobacteria													Bacteria	2E883@1,2I8J4@201174,332M6@2	NA|NA|NA		
MAG.T12.45_00638	1120950.KB892707_gene4769	3.8e-74	285.4	Propionibacteriales	ecfT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656		ko:K02008,ko:K16783,ko:K16785	ko02010,map02010	M00245,M00246,M00581,M00582			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2GKHK@201174,4DPHW@85009,COG0619@1,COG0619@2	NA|NA|NA	P	Cobalt transport protein
MAG.T12.45_00640	1122138.AQUZ01000074_gene7343	2.3e-42	178.3	Propionibacteriales													Bacteria	2DWJQ@1,2IMTZ@201174,340PJ@2,4DV4I@85009	NA|NA|NA		
MAG.T12.45_00641	1122138.AQUZ01000074_gene7344	1.2e-68	266.2	Propionibacteriales													Bacteria	2IJS1@201174,4DUDM@85009,COG1708@1,COG1708@2	NA|NA|NA	S	Nucleotidyltransferase domain
MAG.T12.45_00642	1416759.AYMR01000011_gene320	1.7e-85	323.2	Actinobacteria													Bacteria	2I7P1@201174,COG0457@1,COG0457@2	NA|NA|NA	S	Domain of unknown function (DUF4037)
MAG.T12.45_00643	754252.PFREUD_01970	1.2e-162	579.7	Propionibacteriales													Bacteria	2GN3K@201174,4DPZD@85009,COG3177@1,COG3177@2	NA|NA|NA	S	Fic/DOC family
MAG.T12.45_00644	644548.SCNU_00065	6.9e-23	114.4	Gordoniaceae													Bacteria	2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_00645	367299.JOEE01000004_gene1254	1.1e-20	107.5	Intrasporangiaceae													Bacteria	2CD8B@1,2II9F@201174,30VJG@2,4FI3H@85021	NA|NA|NA		
MAG.T12.45_00646	710696.Intca_0674	9.3e-45	186.8	Intrasporangiaceae				ko:K03088					ko00000,ko03021				Bacteria	2IRNG@201174,4FH7C@85021,COG1595@1,COG1595@2	NA|NA|NA	K	Belongs to the sigma-70 factor family
MAG.T12.45_00647	1313172.YM304_40470	6.1e-10	71.6	Actinobacteria				ko:K11748					ko00000,ko02000	2.A.37.1.2			Bacteria	2DDQ5@1,2HDNV@201174,2ZIVU@2	NA|NA|NA		
MAG.T12.45_00648	882083.SacmaDRAFT_3092	9e-143	513.5	Pseudonocardiales	aslB	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564		ko:K06871					ko00000				Bacteria	2GMTV@201174,4E1AJ@85010,COG0641@1,COG0641@2	NA|NA|NA	C	Radical SAM superfamily
MAG.T12.45_00649	1380356.JNIK01000015_gene2367	4e-299	1033.9	Frankiales			3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Bacteria	2GJ8H@201174,4ETR9@85013,COG3119@1,COG3119@2	NA|NA|NA	P	Sulfatase
MAG.T12.45_00650	1033730.CAHG01000016_gene350	2.2e-81	310.1	Propionibacteriales				ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	2GJCB@201174,4DT31@85009,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate permease family
MAG.T12.45_00651	1517681.HW45_14665	1e-58	233.0	Vibrionales	hpt		2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	1QJNX@1224,1THPU@1236,1XX3B@135623,COG0634@1,COG0634@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T12.45_00656	28444.JODQ01000006_gene351	3.5e-17	95.1	Streptosporangiales				ko:K03088					ko00000,ko03021				Bacteria	2IRNG@201174,4EJSS@85012,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70, region 4
MAG.T12.45_00657	298654.FraEuI1c_2160	2e-69	269.2	Frankiales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GIVW@201174,4ERFD@85013,COG0842@1,COG0842@2	NA|NA|NA	V	PFAM ABC-2 type transporter
MAG.T12.45_00658	208439.AJAP_13005	3.1e-101	375.2	Pseudonocardiales				ko:K01990,ko:K18232	ko02010,map02010	M00254,M00634			ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2			Bacteria	2GIY8@201174,4DXJX@85010,COG1131@1,COG1131@2	NA|NA|NA	V	Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP
MAG.T12.45_00659	500153.JOEK01000003_gene1011	1e-07	62.8	Actinobacteria													Bacteria	2GJZC@201174,COG3595@1,COG3595@2	NA|NA|NA	S	Putative adhesin
MAG.T12.45_00660	1125971.ASJB01000074_gene74	2.1e-35	155.6	Pseudonocardiales													Bacteria	2IKXB@201174,4E3FU@85010,COG4226@1,COG4226@2	NA|NA|NA	S	protein encoded in hypervariable junctions of pilus gene clusters
MAG.T12.45_00662	1713.JOFV01000003_gene1528	1.9e-129	469.2	Cellulomonadaceae	hemD		2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKMM@201174,4F0R3@85016,COG0745@1,COG0745@2,COG1587@1,COG1587@2	NA|NA|NA	HK	PFAM Uroporphyrinogen III synthase HEM4
MAG.T12.45_00663	1380354.JIAN01000005_gene1238	1.4e-75	289.7	Cellulomonadaceae	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.79,1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.99.1.4	ko:K02302,ko:K02303,ko:K02304,ko:K04719,ko:K13541	ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947,R05180,R05809,R07772,R09083	RC00003,RC00435,RC00871,RC01012,RC01034,RC01293,RC01545,RC02097,RC02413,RC03471	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	Bacteria	2GK3B@201174,4F260@85016,COG0007@1,COG0007@2,COG1648@1,COG1648@2	NA|NA|NA	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase
MAG.T12.45_00664	1385519.N801_03455	8.5e-31	139.8	Intrasporangiaceae	nirD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809	1.7.1.15	ko:K00362,ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3772	Bacteria	2IQM4@201174,4FHUA@85021,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
MAG.T12.45_00665	1385518.N798_06760	0.0	1272.7	Intrasporangiaceae	nirB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3849	Bacteria	2GJ3U@201174,4FF81@85021,COG1251@1,COG1251@2	NA|NA|NA	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAG.T12.45_00666	935839.JAGJ01000004_gene1928	1e-81	310.5	Promicromonosporaceae	nasC		1.7.1.15	ko:K00360,ko:K00362	ko00910,ko01120,map00910,map01120	M00530,M00531	R00787,R00798	RC00176,RC02812	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ3U@201174,4F3YI@85017,COG1251@1,COG1251@2	NA|NA|NA	C	BFD-like [2Fe-2S] binding domain
MAG.T12.45_00667	1240349.ANGC01000004_gene1728	3.6e-108	398.3	Nocardiaceae	alx			ko:K05794					ko00000				Bacteria	2GIWU@201174,4FUZ0@85025,COG0861@1,COG0861@2	NA|NA|NA	P	Integral membrane protein TerC family
MAG.T12.45_00668	1397693.KK211187_gene1704	9.2e-202	709.9	Bacillales incertae sedis	cdr2												Bacteria	1TPWW@1239,3WENZ@539002,4HA11@91061,COG0446@1,COG0446@2,COG0607@1,COG0607@2	NA|NA|NA	P	Belongs to the sulfur carrier protein TusA family
MAG.T12.45_00669	861299.J421_2256	1.3e-84	319.7	Gemmatimonadetes	arsM		2.1.1.137	ko:K07755					ko00000,ko01000				Bacteria	1ZSM8@142182,COG0500@1,COG2226@2	NA|NA|NA	Q	Hypothetical methyltransferase
MAG.T12.45_00670	446465.Bfae_31180	5.1e-28	130.6	Dermabacteraceae				ko:K03892					ko00000,ko03000				Bacteria	2IQDH@201174,4FD6A@85020,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T12.45_00671	446471.Xcel_3344	2.1e-53	216.1	Promicromonosporaceae			1.20.4.1	ko:K03741,ko:K03892					ko00000,ko01000,ko03000				Bacteria	2IHR3@201174,4F4G0@85017,COG0394@1,COG0394@2,COG0640@1,COG0640@2	NA|NA|NA	T	Low molecular weight phosphatase family
MAG.T12.45_00672	526225.Gobs_1145	4.7e-48	197.6	Frankiales	MA20_23315												Bacteria	2IIUB@201174,4ESS1@85013,COG1765@1,COG1765@2	NA|NA|NA	O	PFAM OsmC family protein
MAG.T12.45_00673	1463909.KL585957_gene2958	0.0	1080.5	Actinobacteria	bgl2		3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110		R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000		GH3		Bacteria	2GJ5H@201174,COG1472@1,COG1472@2	NA|NA|NA	G	hydrolase, family 3
MAG.T12.45_00674	590998.Celf_0701	1.2e-16	92.8	Bacteria	cbpA		2.4.1.333	ko:K21298					ko00000,ko01000		GH94		Bacteria	COG3459@1,COG3459@2	NA|NA|NA	G	carbohydrate binding
MAG.T12.45_00675	443218.AS9A_2146	2e-50	205.3	Actinobacteria													Bacteria	2CAJE@1,2IMDF@201174,33XCP@2	NA|NA|NA		
MAG.T12.45_00676	1121017.AUFG01000012_gene1807	1.2e-204	719.5	Intrasporangiaceae	malS	GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020		R00214	RC00105	ko00000,ko00001,ko01000				Bacteria	2GJAJ@201174,4FG5T@85021,COG0281@1,COG0281@2	NA|NA|NA	C	Malic enzyme, NAD binding domain
MAG.T12.45_00677	593907.Celgi_1060	2.2e-170	606.3	Cellulomonadaceae				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2H37M@201174,4F1Y9@85016,COG3127@1,COG3127@2	NA|NA|NA	Q	MacB-like periplasmic core domain
MAG.T12.45_00678	1454010.JEOE01000003_gene259	9e-107	393.3	Actinobacteria				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJN6@201174,COG1136@1,COG1136@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_00679	590998.Celf_2529	3.8e-92	344.7	Cellulomonadaceae	tcsR2												Bacteria	2GJ46@201174,4F1QA@85016,COG2197@1,COG2197@2	NA|NA|NA	T	PFAM response regulator receiver
MAG.T12.45_00680	446466.Cfla_2390	3.8e-13	80.5	Cellulomonadaceae													Bacteria	2GJEG@201174,4F1NE@85016,COG4585@1,COG4585@2	NA|NA|NA	T	PFAM histidine kinase dimerisation and phosphoacceptor region
MAG.T12.45_00685	134676.ACPL_5940	3.7e-28	132.1	Micromonosporales	dnaG			ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	2IIZM@201174,4DH41@85008,COG0358@1,COG0358@2	NA|NA|NA	L	Toprim-like
MAG.T12.45_00686	263358.VAB18032_30319	1.4e-12	81.3	Micromonosporales													Bacteria	2DRVP@1,2GQDR@201174,33D9Z@2,4DE7K@85008	NA|NA|NA		
MAG.T12.45_00687	397278.JOJN01000013_gene2576	3.4e-22	112.1	Propionibacteriales													Bacteria	2HKN7@201174,4DQJH@85009,COG1261@1,COG1261@2	NA|NA|NA	NO	SAF
MAG.T12.45_00688	1385519.N801_09650	2.3e-46	192.6	Intrasporangiaceae													Bacteria	2HT5K@201174,4FI0R@85021,COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T12.45_00689	471852.Tcur_3460	2e-19	102.8	Streptosporangiales	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	2GV0M@201174,4EK5F@85012,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MAG.T12.45_00690	1121017.AUFG01000045_gene3633	8e-76	290.0	Intrasporangiaceae	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2987c	Bacteria	2GJ8Z@201174,4FE44@85021,COG0066@1,COG0066@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T12.45_00691	1194165.CAJF01000002_gene2256	5.5e-191	673.7	Microbacteriaceae	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531	Bacteria	2GKT7@201174,4FKI7@85023,COG0065@1,COG0065@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T12.45_00692	981369.JQMJ01000004_gene5712	9.5e-66	257.3	Streptacidiphilus	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GK44@201174,2NHUS@228398,COG0473@1,COG0473@2	NA|NA|NA	CE	Isocitrate/isopropylmalate dehydrogenase
MAG.T12.45_00693	1123322.KB904660_gene1100	1.7e-141	509.2	Actinobacteria	ilvE	GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKJ1@201174,COG0115@1,COG0115@2	NA|NA|NA	E	Branched-chain amino acid aminotransferase
MAG.T12.45_00695	547163.BN979_01132	4.3e-75	288.1	Mycobacteriaceae													Bacteria	235R1@1762,2I97T@201174,COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T12.45_00697	1048339.KB913029_gene2282	5.2e-78	298.1	Frankiales				ko:K08981					ko00000				Bacteria	2GJCD@201174,4EUF4@85013,COG3428@1,COG3428@2	NA|NA|NA	S	Bacterial PH domain
MAG.T12.45_00699	1123320.KB889585_gene1805	1.5e-97	362.8	Actinobacteria													Bacteria	2I2F6@201174,COG5495@1,COG5495@2	NA|NA|NA	S	Oxidoreductase
MAG.T12.45_00700	263358.VAB18032_02725	1.1e-79	303.5	Micromonosporales	panC	GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3602c	Bacteria	2GJEQ@201174,4D99B@85008,COG0414@1,COG0414@2	NA|NA|NA	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MAG.T12.45_00701	1348663.KCH_34820	2.4e-181	642.1	Kitasatospora	nadB		1.3.5.4,1.4.3.16,2.4.2.19	ko:K00244,ko:K00278,ko:K00767	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00115,M00150,M00173	R00357,R00481,R02164,R03348	RC00006,RC00045,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2IJ@201174,2M0NV@2063,COG0029@1,COG0029@2	NA|NA|NA	H	Fumarate reductase flavoprotein C-term
MAG.T12.45_00702	1463845.JOIG01000008_gene3720	2.7e-99	368.6	Actinobacteria	nadC		1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2IP@201174,COG0157@1,COG0157@2	NA|NA|NA	H	Belongs to the NadC ModD family
MAG.T12.45_00703	35754.JNYJ01000036_gene3729	6.3e-97	360.5	Micromonosporales	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1986	Bacteria	2GMRQ@201174,4D9W0@85008,COG1521@1,COG1521@2	NA|NA|NA	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MAG.T12.45_00704	1380390.JIAT01000011_gene2320	3e-124	452.2	Rubrobacteria													Bacteria	2GKEK@201174,4CR6A@84995,COG4320@1,COG4320@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2252)
MAG.T12.45_00705	1380356.JNIK01000002_gene4723	1.6e-08	66.6	Actinobacteria													Bacteria	2EPZ4@1,2GYV7@201174,33HJQ@2	NA|NA|NA		
MAG.T12.45_00706	1386089.N865_13000	5.1e-48	198.0	Actinobacteria				ko:K07025					ko00000				Bacteria	2GN5U@201174,COG1011@1,COG1011@2	NA|NA|NA	S	haloacid dehalogenase
MAG.T12.45_00707	1089544.KB912942_gene4783	1.7e-25	122.5	Pseudonocardiales													Bacteria	2IQMV@201174,4EBME@85010,COG4978@1,COG4978@2	NA|NA|NA	KT	Bacterial transcription activator, effector binding domain
MAG.T12.45_00708	266940.Krad_0596	4.4e-59	234.2	Actinobacteria	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0946	Bacteria	2GJBT@201174,COG1246@1,COG1246@2	NA|NA|NA	E	N-acetylglutamate synthase
MAG.T12.45_00709	1206101.AZXC01000015_gene5031	4.3e-297	1027.3	Actinobacteria	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000			iJN678.ppc,iSFV_1184.SFV_4025	Bacteria	2GKDB@201174,COG2352@1,COG2352@2	NA|NA|NA	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MAG.T12.45_00710	479435.Kfla_6437	4.1e-24	117.5	Propionibacteriales	lsr												Bacteria	2C4MW@1,2IQ6A@201174,32RKK@2,4DRQX@85009	NA|NA|NA	S	Lsr2
MAG.T12.45_00712	36331.EPrPI00000021209	4.1e-08	63.9	Pythiales													Eukaryota	1MD6Y@121069,2CFGF@1,2RWD6@2759	NA|NA|NA	S	Codanin-1 C-terminus
MAG.T12.45_00713	1003195.SCAT_1131	1.8e-83	316.2	Actinobacteria													Bacteria	2GJSF@201174,COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T12.45_00714	40571.JOEA01000002_gene4983	2.8e-18	99.8	Pseudonocardiales													Bacteria	2B1K4@1,2I2R4@201174,32S9C@2,4E7BQ@85010	NA|NA|NA	S	Protein of unknown function (DUF3068)
MAG.T12.45_00716	1043205.AFYF01000075_gene2080	2.1e-36	158.7	Intrasporangiaceae	ydiI												Bacteria	2IKTU@201174,4FGPR@85021,COG2050@1,COG2050@2	NA|NA|NA	Q	protein possibly involved in aromatic compounds catabolism
MAG.T12.45_00717	269800.Tfu_1187	1.2e-66	260.0	Actinobacteria	ydfK			ko:K07150					ko00000				Bacteria	2GM75@201174,COG1811@1,COG1811@2	NA|NA|NA	S	Na channel or pump
MAG.T12.45_00718	1306174.JODP01000013_gene7452	2.2e-91	342.0	Actinobacteria				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GKSQ@201174,COG0410@1,COG0410@2	NA|NA|NA	E	ABC transporter
MAG.T12.45_00719	1306174.JODP01000013_gene7453	6e-101	374.0	Actinobacteria				ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMEE@201174,COG0411@1,COG0411@2	NA|NA|NA	E	ABC transporter
MAG.T12.45_00720	1306174.JODP01000013_gene7454	1.7e-09	68.2	Actinobacteria	livM			ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GJB3@201174,COG4177@1,COG4177@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_00721	1499680.CCFE01000011_gene564	1.9e-69	270.0	Firmicutes													Bacteria	1V0SJ@1239,COG5434@1,COG5434@2	NA|NA|NA	M	Parallel beta-helix repeats
MAG.T12.45_00722	1081644.IMCC13023_01920	2.3e-192	678.3	Microbacteriaceae	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMP4@201174,4FKSZ@85023,COG0104@1,COG0104@2	NA|NA|NA	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MAG.T12.45_00723	479433.Caci_8387	1.9e-32	145.2	Actinobacteria	fbaA	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z4263	Bacteria	2GM5P@201174,COG0191@1,COG0191@2	NA|NA|NA	G	fructose-bisphosphate aldolase
MAG.T12.45_00724	1122138.AQUZ01000033_gene3629	1.3e-78	300.1	Propionibacteriales	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576											Bacteria	2GJBA@201174,4DN7Y@85009,COG1376@1,COG1376@2	NA|NA|NA	S	L,D-transpeptidase catalytic domain
MAG.T12.45_00725	1193181.BN10_900020	3e-11	73.9	Intrasporangiaceae	fieF												Bacteria	2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2	NA|NA|NA	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAG.T12.45_00727	926569.ANT_00100	6.7e-55	220.7	Chloroflexi	sdpI												Bacteria	2G714@200795,COG5658@1,COG5658@2	NA|NA|NA	S	SdpI/YhfL protein family
MAG.T12.45_00728	1429046.RR21198_2521	5.5e-160	570.9	Nocardiaceae													Bacteria	2GM4J@201174,4FY11@85025,COG4584@1,COG4584@2	NA|NA|NA	L	Transposase
MAG.T12.45_00729	1268303.RHODMAR_4992	8.8e-38	162.9	Nocardiaceae													Bacteria	2H714@201174,4FXQJ@85025,COG1484@1,COG1484@2	NA|NA|NA	L	IstB-like ATP binding protein
MAG.T12.45_00730	487521.OCU_28920	5.5e-111	408.3	Bacteria													Bacteria	COG0542@1,COG0542@2	NA|NA|NA	O	response to heat
MAG.T12.45_00732	1048339.KB913029_gene2728	2.5e-69	268.5	Frankiales	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601					ko00000,ko03009,ko03021				Bacteria	2GJFW@201174,4ES8J@85013,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination
MAG.T12.45_00733	1155718.KB891885_gene6434	1.3e-62	245.7	Actinobacteria	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02867	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFCK@201174,COG0080@1,COG0080@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MAG.T12.45_00734	1089455.MOPEL_098_00060	1e-101	376.3	Dermatophilaceae	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02863	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GM51@201174,4F6JF@85018,COG0081@1,COG0081@2	NA|NA|NA	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MAG.T12.45_00735	367299.JOEE01000001_gene2148	1.4e-60	239.6	Intrasporangiaceae	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02864,ko:K02935	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GM0V@201174,4FEG8@85021,COG0244@1,COG0244@2	NA|NA|NA	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MAG.T12.45_00736	446471.Xcel_1943	5.3e-101	375.6	Actinobacteria													Bacteria	2I8CR@201174,COG0464@1,COG0464@2	NA|NA|NA	O	PFAM AAA ATPase central domain protein
MAG.T12.45_00739	446471.Xcel_1946	1.3e-135	490.3	Actinobacteria													Bacteria	2ERBG@1,2GPQE@201174,33IX4@2	NA|NA|NA		
MAG.T12.45_00740	446471.Xcel_1947	6.7e-116	424.9	Actinobacteria													Bacteria	28Q0Z@1,2IAZ4@201174,2ZCJM@2	NA|NA|NA		
MAG.T12.45_00741	446471.Xcel_1948	4.3e-65	256.5	Actinobacteria				ko:K02040,ko:K20276,ko:K21449	ko02010,ko02020,ko02024,ko05152,map02010,map02020,map02024,map05152	M00222			ko00000,ko00001,ko00002,ko02000	1.B.40.2,3.A.1.7			Bacteria	2IRA0@201174,COG4223@1,COG4223@2	NA|NA|NA	M	COG3209 Rhs family protein
MAG.T12.45_00742	446471.Xcel_1949	5e-147	528.5	Actinobacteria													Bacteria	2I52J@201174,COG3391@1,COG3391@2	NA|NA|NA	S	Phage tail protein (Tail_P2_I)
MAG.T12.45_00743	446471.Xcel_1950	1.4e-217	762.7	Actinobacteria													Bacteria	2GM5C@201174,COG3299@1,COG3299@2	NA|NA|NA	S	Baseplate J-like protein
MAG.T12.45_00744	446471.Xcel_1951	2.4e-44	184.9	Actinobacteria				ko:K06903					ko00000				Bacteria	2IFJ6@201174,COG3628@1,COG3628@2	NA|NA|NA	S	GPW gp25 family protein
MAG.T12.45_00746	446471.Xcel_1953	2.2e-39	169.5	Actinobacteria													Bacteria	2GP13@201174,COG3501@1,COG3501@2	NA|NA|NA	S	Rhs element Vgr protein
MAG.T12.45_00747	446471.Xcel_1954	7.5e-137	493.8	Bacteria				ko:K06905					ko00000				Bacteria	COG3500@1,COG3500@2	NA|NA|NA		
MAG.T12.45_00748	446471.Xcel_1955	2e-73	282.3	Actinobacteria													Bacteria	2IAAU@201174,COG1652@1,COG1652@2	NA|NA|NA	S	PFAM Peptidoglycan-binding
MAG.T12.45_00750	379066.GAU_3439	2e-36	159.1	Bacteria													Bacteria	2DMQT@1,32T2H@2	NA|NA|NA	S	T4-like virus tail tube protein gp19
MAG.T12.45_00751	446471.Xcel_1958	5.3e-180	637.9	Actinobacteria				ko:K06907					ko00000				Bacteria	2IG6A@201174,COG3497@1,COG3497@2	NA|NA|NA	S	Phage tail sheath protein subtilisin-like domain
MAG.T12.45_00752	446471.Xcel_1959	9e-56	223.0	Actinobacteria													Bacteria	2DB76@1,2GKK0@201174,2Z7JZ@2	NA|NA|NA	S	T4-like virus tail tube protein gp19
MAG.T12.45_00753	446471.Xcel_1960	0.0	1246.9	Actinobacteria				ko:K06907					ko00000				Bacteria	2GMJA@201174,COG3497@1,COG3497@2	NA|NA|NA	S	tail sheath protein
MAG.T12.45_00754	446471.Xcel_1961	4.4e-07	61.6	Bacteria													Bacteria	2EA5X@1,334AT@2	NA|NA|NA		
MAG.T12.45_00755	1504319.GM45_5765	1.5e-91	342.4	unclassified Actinobacteria (class)	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	2GKNK@201174,3UWGF@52018,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MAG.T12.45_00756	1048339.KB913029_gene4876	1.7e-84	318.9	Frankiales	clpP		3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	2GK5C@201174,4ES45@85013,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MAG.T12.45_00757	313589.JNB_05894	7.7e-103	380.9	Intrasporangiaceae	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K03545					ko00000				Bacteria	2GJIG@201174,4FF93@85021,COG0544@1,COG0544@2	NA|NA|NA	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MAG.T12.45_00760	710696.Intca_0333	2e-27	129.4	Intrasporangiaceae													Bacteria	2GUWM@201174,4FJA2@85021,COG1708@1,COG1708@2	NA|NA|NA	L	Nucleotidyltransferase domain
MAG.T12.45_00761	1121924.ATWH01000014_gene3488	5.3e-10	70.9	Microbacteriaceae													Bacteria	2GYNE@201174,4FSSM@85023,COG2250@1,COG2250@2	NA|NA|NA	S	HEPN domain
MAG.T12.45_00762	1348663.KCH_26840	8.9e-38	162.9	Kitasatospora	zur	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02076,ko:K03711,ko:K09823	ko02024,map02024				ko00000,ko00001,ko03000				Bacteria	2IKS3@201174,2M2R1@2063,COG0735@1,COG0735@2	NA|NA|NA	P	Ferric uptake regulator family
MAG.T12.45_00763	1120936.KB907220_gene1908	7.3e-57	227.6	Streptosporangiales	scbA			ko:K09815	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5			Bacteria	2GM1K@201174,4EHVW@85012,COG0803@1,COG0803@2	NA|NA|NA	P	Zinc-uptake complex component A periplasmic
MAG.T12.45_00764	935866.JAER01000041_gene3044	1.2e-58	233.4	Propionibacteriales	mntB			ko:K09817	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5			Bacteria	2GP3A@201174,4DPIC@85009,COG1121@1,COG1121@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T12.45_00765	1237500.ANBA01000009_gene1397	2.5e-67	262.3	Streptosporangiales				ko:K09816	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5			Bacteria	2GJ7H@201174,4EI6R@85012,COG1108@1,COG1108@2	NA|NA|NA	P	ABC 3 transport family
MAG.T12.45_00766	219305.MCAG_01801	2e-48	199.1	Micromonosporales	apl		3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147				Bacteria	2GN43@201174,4D91R@85008,COG0586@1,COG0586@2	NA|NA|NA	S	SNARE associated Golgi protein
MAG.T12.45_00767	266940.Krad_4341	1e-138	500.7	Actinobacteria	mrcB		2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	2GK21@201174,COG0744@1,COG0744@2	NA|NA|NA	M	penicillin-binding protein
MAG.T12.45_00768	33898.JRHJ01000025_gene6653	4e-26	126.7	Actinobacteria													Bacteria	2GXEC@201174,COG0739@1,COG0739@2	NA|NA|NA	M	peptidase
MAG.T12.45_00769	585531.HMPREF0063_11333	1.5e-43	183.0	Propionibacteriales													Bacteria	2IDJT@201174,4DSNS@85009,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_00770	1078020.KEK_17748	6e-25	120.6	Mycobacteriaceae	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000				Bacteria	238KS@1762,2IQF6@201174,COG0736@1,COG0736@2	NA|NA|NA	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MAG.T12.45_00771	1370120.AUWR01000062_gene4039	0.0	2078.9	Mycobacteriaceae	fas		2.3.1.179	ko:K09458,ko:K11533	ko00061,ko00780,ko01100,ko01212,ko04931,map00061,map00780,map01100,map01212,map04931	M00082,M00083,M00572	R01624,R01626,R04355,R04428,R04429,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04724,R04726,R04952,R04953,R04954,R04955,R04957,R04958,R04960,R04961,R04963,R04964,R04965,R04966,R04968,R04969,R07762,R07763,R07764,R07765,R10115,R10119,R10700	RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	234D6@1762,2GIY4@201174,COG0304@1,COG0304@2,COG0331@1,COG0331@2,COG2030@1,COG2030@2,COG4981@1,COG4981@2	NA|NA|NA	IQ	synthase
MAG.T12.45_00772	1003195.SCAT_1341	3.1e-233	814.7	Actinobacteria	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982					ko00000,ko01000				Bacteria	2GJ91@201174,COG1391@1,COG1391@2	NA|NA|NA	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
MAG.T12.45_00774	1343740.M271_17085	3.4e-48	198.7	Actinobacteria	atpH			ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2GMJ5@201174,COG0712@1,COG0712@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T12.45_00775	1122175.ATXU01000001_gene931	5.5e-34	151.0	Microbacteriaceae	atpF			ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2GJS4@201174,4FNEE@85023,COG0711@1,COG0711@2	NA|NA|NA	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAG.T12.45_00776	1504319.GM45_6080	1.5e-27	128.3	unclassified Actinobacteria (class)	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2HGDC@201174,3UWZI@52018,COG0636@1,COG0636@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T12.45_00777	1504319.GM45_6075	1.7e-68	266.2	unclassified Actinobacteria (class)	atpB			ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1			Bacteria	2H3PR@201174,3UWN7@52018,COG0356@1,COG0356@2	NA|NA|NA	C	it plays a direct role in the translocation of protons across the membrane
MAG.T12.45_00778	1504319.GM45_6070	7.2e-14	83.2	Bacteria													Bacteria	2972E@1,2ZUAS@2	NA|NA|NA		
MAG.T12.45_00779	1713.JOFV01000002_gene496	1.1e-10	73.2	Cellulomonadaceae	atpI			ko:K02116					ko00000,ko00194	3.A.2.1			Bacteria	2BJAR@1,2GR4T@201174,32DKN@2,4F1BV@85016	NA|NA|NA		
MAG.T12.45_00780	1504319.GM45_6060	2.6e-91	342.4	unclassified Actinobacteria (class)	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	2GIT7@201174,3UWGE@52018,COG0472@1,COG0472@2	NA|NA|NA	M	Glycosyl transferase family 4
MAG.T12.45_00781	1146883.BLASA_3927	2.2e-187	661.8	Frankiales	glyA		2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK7U@201174,4ERC5@85013,COG0112@1,COG0112@2	NA|NA|NA	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MAG.T12.45_00782	222534.KB893751_gene4143	1.2e-40	173.3	Frankiales	ywlC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	2GK2X@201174,4ESEK@85013,COG0009@1,COG0009@2	NA|NA|NA	J	Belongs to the SUA5 family
MAG.T12.45_00783	1120950.KB892745_gene2866	4.9e-67	261.5	Propionibacteriales	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493			R10806	RC00003,RC03279	ko00000,ko01000,ko03012				Bacteria	2GMH1@201174,4DP23@85009,COG2890@1,COG2890@2	NA|NA|NA	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MAG.T12.45_00784	1210045.ALNP01000028_gene897	1.1e-136	493.0	Actinobacteria	prfA			ko:K02835					ko00000,ko03012				Bacteria	2GJWG@201174,COG0216@1,COG0216@2	NA|NA|NA	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MAG.T12.45_00785	471852.Tcur_3932	1.3e-28	131.7	Streptosporangiales	rpmE			ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ4I@201174,4EK8U@85012,COG0254@1,COG0254@2	NA|NA|NA	J	Binds the 23S rRNA
MAG.T12.45_00786	1449069.JMLO01000004_gene3655	2.8e-123	448.7	Nocardiaceae	proP												Bacteria	2I2EY@201174,4G9I9@85025,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_00787	1463900.JOIX01000064_gene2762	1.7e-124	452.2	Actinobacteria	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03628	ko03018,map03018				ko00000,ko00001,ko03019,ko03021				Bacteria	2GIWY@201174,COG1158@1,COG1158@2	NA|NA|NA	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MAG.T12.45_00790	1236902.ANAS01000009_gene2473	4.6e-73	282.3	Streptosporangiales			3.5.1.104	ko:K22278					ko00000,ko01000				Bacteria	2HEQK@201174,4EI91@85012,COG0726@1,COG0726@2	NA|NA|NA	G	Polysaccharide deacetylase
MAG.T12.45_00791	485913.Krac_5846	5.3e-173	614.0	Chloroflexi	gadB		4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3432c	Bacteria	2G76V@200795,COG0076@1,COG0076@2	NA|NA|NA	H	COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein
MAG.T12.45_00792	1278078.G419_22134	8.7e-261	906.4	Nocardiaceae			3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2			Bacteria	2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2	NA|NA|NA	P	PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein
MAG.T12.45_00793	479431.Namu_1914	9.4e-104	383.3	Frankiales	nagD			ko:K02566					ko00000				Bacteria	2GJG6@201174,4EU6R@85013,COG0647@1,COG0647@2	NA|NA|NA	G	Belongs to the HAD-like hydrolase superfamily
MAG.T12.45_00794	479431.Namu_1913	1.2e-114	419.9	Actinobacteria	egsA		1.1.1.261	ko:K00096	ko00564,map00564		R05679,R05680	RC00029	ko00000,ko00001,ko01000				Bacteria	2GKWA@201174,COG0371@1,COG0371@2	NA|NA|NA	C	Dehydrogenase
MAG.T12.45_00795	479431.Namu_4836	4.3e-104	384.8	Frankiales	alx			ko:K05794					ko00000				Bacteria	2GIWU@201174,4ERNE@85013,COG0861@1,COG0861@2	NA|NA|NA	P	membrane protein, TerC
MAG.T12.45_00796	1283283.ATXA01000007_gene3910	1.7e-120	440.3	Frankiales													Bacteria	2GIZF@201174,4ERVM@85013,COG5001@1,COG5001@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T12.45_00797	590998.Celf_3653	8.9e-51	208.4	Actinobacteria													Bacteria	2GIZF@201174,COG2202@1,COG2202@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2	NA|NA|NA	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain
MAG.T12.45_00798	1445613.JALM01000036_gene2693	1.6e-11	75.5	Pseudonocardiales													Bacteria	2DGB7@1,2GV3X@201174,2ZV98@2,4E6RY@85010	NA|NA|NA		
MAG.T12.45_00799	2074.JNYD01000016_gene4270	1.6e-55	222.2	Pseudonocardiales				ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2GITR@201174,4DYWM@85010,COG1132@1,COG1132@2	NA|NA|NA	V	ABC transporter transmembrane region
MAG.T12.45_00800	263358.VAB18032_01020	2.3e-46	191.4	Micromonosporales	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112		ko:K02986	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GIRX@201174,4D9VD@85008,COG0522@1,COG0522@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MAG.T12.45_00801	1205680.CAKO01000006_gene3147	8.1e-13	78.6	Rhodospirillales	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002				Bacteria	1MW4K@1224,2JPT2@204441,2TQPM@28211,COG0449@1,COG0449@2	NA|NA|NA	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MAG.T12.45_00802	644283.Micau_2429	2.7e-98	365.5	Micromonosporales				ko:K07483					ko00000				Bacteria	2GS79@201174,4D9V4@85008,COG3547@1,COG3547@2	NA|NA|NA	L	transposase IS116 IS110 IS902 family protein
MAG.T12.45_00806	590998.Celf_3039	3.7e-223	781.9	Actinobacteria													Bacteria	2GN7G@201174,COG3291@1,COG3291@2	NA|NA|NA	P	PFAM PKD domain containing protein
MAG.T12.45_00807	1463825.JNXC01000017_gene6951	1.3e-92	346.7	Pseudonocardiales				ko:K00713,ko:K06338					ko00000,ko01000,ko01003,ko01005				Bacteria	2I005@201174,4DXXN@85010,COG0438@1,COG0438@2	NA|NA|NA	M	PFAM Glycosyl transferases group 1
MAG.T12.45_00808	1463825.JNXC01000017_gene6952	2.6e-220	771.9	Pseudonocardiales													Bacteria	2GIUI@201174,4DXAD@85010,COG3408@1,COG3408@2	NA|NA|NA	G	Glycogen debranching enzyme
MAG.T12.45_00809	935839.JAGJ01000016_gene2363	2e-38	165.6	Promicromonosporaceae													Bacteria	2IM6D@201174,4F4NF@85017,COG4119@1,COG4119@2	NA|NA|NA	L	NUDIX domain
MAG.T12.45_00811	33876.JNXY01000028_gene3328	6.2e-07	62.4	Micromonosporales													Bacteria	2BNCX@1,2H4ZP@201174,32H0K@2,4DIXP@85008	NA|NA|NA		
MAG.T12.45_00813	1394178.AWOO02000082_gene2172	1.9e-18	101.7	Streptosporangiales													Bacteria	2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2	NA|NA|NA	K	AAA ATPase domain
MAG.T12.45_00814	1038860.AXAP01000018_gene3103	4e-40	171.0	Bradyrhizobiaceae													Bacteria	1RGXV@1224,2U9EH@28211,3JY58@41294,COG5579@1,COG5579@2	NA|NA|NA	S	Protein of unknown function (DUF1810)
MAG.T12.45_00815	1122130.AUHN01000005_gene2450	2.7e-23	116.3	Bacteria			3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100		R01206,R02334	RC00467	ko00000,ko00001,ko01000		GH18		Bacteria	COG2374@1,COG2374@2,COG4733@1,COG4733@2	NA|NA|NA	S	cellulase activity
MAG.T12.45_00817	315749.Bcer98_2749	6.4e-150	537.7	Bacillus	ptsG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.193,2.7.1.199,2.7.1.208,2.7.1.211	ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00267,M00269,M00271,M00806,M00809	R00811,R02738,R04111,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9			Bacteria	1TPJ8@1239,1ZC48@1386,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	phosphotransferase system
MAG.T12.45_00818	153721.MYP_828	1.6e-26	127.5	Bacteria													Bacteria	2EPPK@1,33HA5@2	NA|NA|NA		
MAG.T12.45_00819	1304865.JAGF01000001_gene125	5.9e-133	481.1	Actinobacteria													Bacteria	2IA73@201174,COG1085@1,COG1085@2	NA|NA|NA	C	uridylyltransferase
MAG.T12.45_00820	1123321.KB905815_gene3283	1.6e-19	101.3	Actinobacteria	sepF	GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0051301,GO:0071840,GO:0090529		ko:K09772					ko00000,ko03036				Bacteria	2GNVH@201174,COG1799@1,COG1799@2	NA|NA|NA	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MAG.T12.45_00821	1184609.KILIM_034_00410	1e-15	89.4	Dermatophilaceae	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02221					ko00000,ko02044				Bacteria	2GQI1@201174,4F798@85018,COG0762@1,COG0762@2	NA|NA|NA	S	YGGT family
MAG.T12.45_00822	397278.JOJN01000020_gene3759	4.3e-08	64.7	Propionibacteriales	wag31	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944											Bacteria	2GMSC@201174,4DQHF@85009,COG3599@1,COG3599@2	NA|NA|NA	D	Cell division initiation protein
MAG.T12.45_00823	935866.JAER01000007_gene424	1.7e-41	177.2	Propionibacteriales													Bacteria	2AUNZ@1,2GP4I@201174,31KBW@2,4DRN6@85009	NA|NA|NA	S	Protein of unknown function (DUF2786)
MAG.T12.45_00824	1048339.KB913029_gene4568	1.9e-174	619.0	Frankiales	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_0027,iPC815.YPO0475	Bacteria	2GK9M@201174,4ERW9@85013,COG0060@1,COG0060@2	NA|NA|NA	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MAG.T12.45_00825	1385519.N801_00635	1.2e-82	313.5	Intrasporangiaceae													Bacteria	2GIS3@201174,4FGCG@85021,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T12.45_00827	1278073.MYSTI_01666	2.1e-45	189.5	Myxococcales	sua5	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	1MVPM@1224,2WP34@28221,2YV20@29,42T6S@68525,COG0009@1,COG0009@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MAG.T12.45_00831	1132441.KI519454_gene683	7.7e-141	507.3	Micrococcaceae	glnP			ko:K02029,ko:K02030		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	1W836@1268,2GJJ9@201174,COG0765@1,COG0765@2,COG0834@1,COG0834@2	NA|NA|NA	P	Bacterial extracellular solute-binding proteins, family 3
MAG.T12.45_00832	1001240.GY21_10825	3e-91	341.7	Microbacteriaceae	glnQ		3.6.3.21	ko:K02028,ko:K10038	ko02010,map02010	M00227,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.2			Bacteria	2GIZW@201174,4FKHI@85023,COG1126@1,COG1126@2	NA|NA|NA	E	ATPases associated with a variety of cellular activities
MAG.T12.45_00833	1120936.KB907209_gene1749	1.8e-184	652.5	Streptosporangiales			3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJJ4@201174,4EHVC@85012,COG0308@1,COG0308@2	NA|NA|NA	E	ERAP1-like C-terminal domain
MAG.T12.45_00834	1454010.JEOE01000011_gene2418	2.1e-217	762.3	Cellulomonadaceae	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13,GH77	iJN678.malQ	Bacteria	2GM5Z@201174,4F0RR@85016,COG1640@1,COG1640@2	NA|NA|NA	G	PFAM glycoside hydrolase family 77
MAG.T12.45_00835	1095767.CAHD01000001_gene2417	9.8e-19	99.8	Cellulomonadaceae	pcaD												Bacteria	2GNFU@201174,4F175@85016,COG0596@1,COG0596@2	NA|NA|NA	S	PFAM alpha beta hydrolase fold
MAG.T12.45_00836	1341646.CBMO010000130_gene3119	5.2e-40	171.4	Mycobacteriaceae	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K01087,ko:K16055	ko00500,ko01100,map00500,map01100		R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Bacteria	233CH@1762,2I3PZ@201174,COG1877@1,COG1877@2	NA|NA|NA	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose
MAG.T12.45_00837	1095767.CAHD01000098_gene1578	3.7e-111	408.3	Cellulomonadaceae	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100		R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20		Bacteria	2GMX7@201174,4F0SW@85016,COG0380@1,COG0380@2	NA|NA|NA	G	PFAM glycosyl transferase family 20
MAG.T12.45_00838	351607.Acel_0539	6.4e-18	96.7	Frankiales	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141											Bacteria	2IM2X@201174,4ETFE@85013,COG5662@1,COG5662@2	NA|NA|NA	K	anti-sigma factor
MAG.T12.45_00839	446471.Xcel_2492	3.3e-81	308.1	Promicromonosporaceae	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K03088					ko00000,ko03021				Bacteria	2GJ02@201174,4F3JN@85017,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70, region 4
MAG.T12.45_00842	1380346.JNIH01000001_gene4275	5.8e-41	174.5	Actinobacteria				ko:K07020					ko00000				Bacteria	2GKKE@201174,COG3571@1,COG3571@2	NA|NA|NA	S	Hydrolase of the alpha beta-hydrolase
MAG.T12.45_00843	469371.Tbis_2926	1.1e-66	260.0	Pseudonocardiales													Bacteria	2GKY8@201174,4E13E@85010,COG2135@1,COG2135@2	NA|NA|NA	S	Belongs to the SOS response-associated peptidase family
MAG.T12.45_00844	1429046.RR21198_0802	2.9e-142	511.9	Nocardiaceae	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJKX@201174,4FU48@85025,COG0128@1,COG0128@2	NA|NA|NA	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MAG.T12.45_00845	1385518.N798_08960	7.5e-106	390.6	Intrasporangiaceae	rsgA		3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100		R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009				Bacteria	2GJ37@201174,4FEQ3@85021,COG1162@1,COG1162@2	NA|NA|NA	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MAG.T12.45_00847	1463841.JOIR01000009_gene4116	6.6e-78	297.4	Actinobacteria	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKZZ@201174,COG0483@1,COG0483@2	NA|NA|NA	G	inositol monophosphatase
MAG.T12.45_00849	235985.BBPN01000033_gene11	4.3e-65	255.0	Streptacidiphilus													Bacteria	2GKUU@201174,2NH2E@228398,COG3173@1,COG3173@2	NA|NA|NA	S	Phosphotransferase enzyme family
MAG.T12.45_00850	1306174.JODP01000006_gene3393	1.3e-28	132.9	Actinobacteria													Bacteria	2IHPB@201174,COG0517@1,COG0517@2	NA|NA|NA	S	Cbs domain
MAG.T12.45_00851	926560.KE387023_gene3341	9.5e-85	320.9	Deinococcus-Thermus	cyp132		1.14.15.24	ko:K22492	ko00906,map00906		R07558,R07559,R09747	RC00478,RC02629	ko00000,ko00001,ko00199,ko01000				Bacteria	1WIX6@1297,COG2124@1,COG2124@2	NA|NA|NA	Q	cytochrome P450
MAG.T12.45_00852	1172180.KB911793_gene3537	8.1e-107	393.7	Actinobacteria													Bacteria	2GKRN@201174,COG2326@1,COG2326@2	NA|NA|NA	G	polyphosphate kinase
MAG.T12.45_00854	1211815.CBYP010000036_gene2210	4e-62	245.7	Frankiales													Bacteria	2GK1J@201174,4ERY7@85013,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_00855	1313172.YM304_19260	3.4e-54	218.4	Acidimicrobiia													Bacteria	2GKFS@201174,4CMYH@84992,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T12.45_00856	1380370.JIBA01000005_gene614	2.9e-63	248.8	Intrasporangiaceae													Bacteria	2IMQQ@201174,4FFD0@85021,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T12.45_00857	188626.HMPREF0321_0345	2.3e-117	429.5	Dermacoccaceae	deaD		3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1ZVH9@145357,2GIUR@201174,COG0513@1,COG0513@2	NA|NA|NA	L	helicase superfamily c-terminal domain
MAG.T12.45_00858	494419.ALPM01000021_gene79	1.5e-113	417.2	Micrococcaceae													Bacteria	1WB1I@1268,2GIZF@201174,COG5001@1,COG5001@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_00859	1123320.KB889629_gene7866	3.3e-15	88.2	Actinobacteria													Bacteria	2GVSD@201174,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T12.45_00860	1122611.KB903988_gene7185	2.5e-110	405.2	Streptosporangiales	panB		2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJP6@201174,4EGTN@85012,COG0413@1,COG0413@2	NA|NA|NA	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MAG.T12.45_00861	1122609.AUGT01000001_gene2813	3.9e-13	80.1	Propionibacteriales													Bacteria	2EHMB@1,2I3MM@201174,33BD3@2,4DS27@85009	NA|NA|NA		
MAG.T12.45_00862	68194.JNXR01000024_gene1245	3.9e-124	451.1	Actinobacteria	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	2GKIZ@201174,COG0024@1,COG0024@2	NA|NA|NA	E	Methionine aminopeptidase
MAG.T12.45_00863	1123320.KB889698_gene9298	2.4e-38	165.2	Actinobacteria													Bacteria	2GP6A@201174,COG1846@1,COG1846@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_00865	253839.SSNG_02891	2.3e-103	382.1	Actinobacteria	cbiO			ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GJ0M@201174,COG1122@1,COG1122@2	NA|NA|NA	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system
MAG.T12.45_00866	1352941.M877_24670	5.5e-75	287.7	Actinobacteria	cbiQ			ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GKQ7@201174,COG0619@1,COG0619@2	NA|NA|NA	P	Cobalt ABC transporter
MAG.T12.45_00867	1463909.KL585974_gene2013	1.8e-30	139.8	Actinobacteria			5.4.99.28,5.4.99.29	ko:K06177,ko:K07052					ko00000,ko01000,ko03009,ko03016				Bacteria	2GKRA@201174,COG1266@1,COG1266@2	NA|NA|NA	S	Abortive infection protein
MAG.T12.45_00868	882086.SacxiDRAFT_2995	2.1e-20	105.9	Pseudonocardiales													Bacteria	2CK3K@1,2IQJH@201174,32SBH@2,4E5Q5@85010	NA|NA|NA	S	PFAM Ion channel
MAG.T12.45_00869	369723.Strop_2938	8.5e-08	64.3	Micromonosporales	ywiC												Bacteria	28NT3@1,2IIC3@201174,2ZBRV@2,4DD9K@85008	NA|NA|NA	S	YwiC-like protein
MAG.T12.45_00870	1169154.KB897777_gene3606	1.1e-19	101.7	Actinobacteria													Bacteria	2E3JZ@1,2GQIX@201174,32YI8@2	NA|NA|NA		
MAG.T12.45_00871	1184607.AUCHE_04_00900	3.3e-48	198.0	Dermatophilaceae													Bacteria	2IHNE@201174,4F6ZV@85018,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
MAG.T12.45_00872	269800.Tfu_0115	2.2e-42	179.5	Streptosporangiales	MA20_36340												Bacteria	2GN6D@201174,4EFJ2@85012,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX hydrolase
MAG.T12.45_00873	653045.Strvi_9002	6.2e-100	370.9	Actinobacteria	arsA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.3.16	ko:K01551					ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1			Bacteria	2GJ0J@201174,COG0003@1,COG0003@2	NA|NA|NA	D	Pfam Anion-transporting ATPase
MAG.T12.45_00874	105420.BBPO01000071_gene4045	5.4e-140	504.2	Streptacidiphilus	arsA		3.6.3.16	ko:K01551					ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1			Bacteria	2GJYN@201174,2NHKM@228398,COG0003@1,COG0003@2	NA|NA|NA	D	Anion-transporting ATPase
MAG.T12.45_00875	1504319.GM45_3810	1.2e-180	640.2	unclassified Actinobacteria (class)	pon1		2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	2GK21@201174,3UW69@52018,COG0744@1,COG0744@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T12.45_00876	1137269.AZWL01000006_gene6602	1.2e-31	142.9	Actinobacteria	yqeY			ko:K09117					ko00000				Bacteria	2IFFJ@201174,COG1610@1,COG1610@2	NA|NA|NA	S	GatB YqeY
MAG.T12.45_00877	1120950.KB892762_gene5503	3.5e-78	298.5	Propionibacteriales	ykuE			ko:K07098					ko00000				Bacteria	2GJHT@201174,4DNBM@85009,COG1408@1,COG1408@2	NA|NA|NA	S	Calcineurin-like phosphoesterase
MAG.T12.45_00878	1032480.MLP_53280	3e-22	110.9	Actinobacteria													Bacteria	2BXAD@1,2IQGA@201174,33WG5@2	NA|NA|NA		
MAG.T12.45_00879	1032480.MLP_53290	6.5e-41	174.5	Actinobacteria													Bacteria	2D5EC@1,2GPZ6@201174,32TIW@2	NA|NA|NA		
MAG.T12.45_00881	1229780.BN381_80248	4.9e-137	495.0	Actinobacteria													Bacteria	2GK2A@201174,COG5421@1,COG5421@2	NA|NA|NA	L	Transposase
MAG.T12.45_00883	33876.JNXY01000002_gene363	5e-51	209.5	Actinobacteria													Bacteria	2IR52@201174,COG1525@1,COG1525@2	NA|NA|NA	L	Lamin Tail Domain
MAG.T12.45_00884	1150399.AQYK01000002_gene2654	4.6e-205	721.5	Microbacteriaceae	tagX		2.7.8.12	ko:K09809					ko00000,ko01000				Bacteria	2GM0T@201174,4FK9M@85023,COG0438@1,COG0438@2,COG1887@1,COG1887@2	NA|NA|NA	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
MAG.T12.45_00885	1121385.AQXW01000004_gene3278	9.4e-15	86.3	Dermacoccaceae	phhB		3.5.4.33,4.2.1.96	ko:K01724,ko:K11991	ko00790,map00790		R04734,R10223	RC00477,RC01208	ko00000,ko00001,ko01000,ko03016,ko04147				Bacteria	1ZW7J@145357,2IHZE@201174,COG2154@1,COG2154@2	NA|NA|NA	H	Pterin 4 alpha carbinolamine dehydratase
MAG.T12.45_00887	1043493.BBLU01000021_gene657	3.1e-54	218.0	Actinobacteria				ko:K06929					ko00000				Bacteria	2IJYY@201174,COG1832@1,COG1832@2	NA|NA|NA	S	PFAM CoA-binding domain protein
MAG.T12.45_00888	1463856.JOHY01000043_gene7260	7.9e-184	650.2	Actinobacteria	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.399,1.1.1.95	ko:K00058,ko:K03977	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147				Bacteria	2GJ8J@201174,COG1160@1,COG1160@2	NA|NA|NA	F	GTPase that plays an essential role in the late steps of ribosome biogenesis
MAG.T12.45_00889	1229203.KI301992_gene1081	1e-56	226.9	unclassified Actinobacteria (class)	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945,ko:K03977	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2H3SI@201174,3UWT7@52018,COG0283@1,COG0283@2	NA|NA|NA	F	Cytidylate kinase
MAG.T12.45_00890	1210046.B277_08400	4.7e-82	311.6	Intrasporangiaceae	tyrA		1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKB4@201174,4FF8J@85021,COG0287@1,COG0287@2	NA|NA|NA	E	Prephenate dehydrogenase
MAG.T12.45_00891	1463881.KL591011_gene2890	7.2e-35	153.3	Actinobacteria	aroH	GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704	2.7.4.25,5.4.99.5	ko:K00945,ko:K06208	ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230	M00024,M00025,M00052	R00158,R00512,R01665,R01715	RC00002,RC03116	ko00000,ko00001,ko00002,ko01000				Bacteria	2IHWT@201174,COG4401@1,COG4401@2	NA|NA|NA	E	Chorismate mutase
MAG.T12.45_00892	1184607.AUCHE_05_03990	2.2e-83	315.5	Dermatophilaceae	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183					ko00000,ko01000,ko03009				Bacteria	2GJ4N@201174,4F65G@85018,COG1187@1,COG1187@2	NA|NA|NA	J	RNA pseudouridylate synthase
MAG.T12.45_00893	1122611.KB904029_gene5405	5.3e-54	217.6	Streptosporangiales	scpB			ko:K06024					ko00000,ko03036				Bacteria	2GISY@201174,4EG7D@85012,COG1386@1,COG1386@2	NA|NA|NA	K	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MAG.T12.45_00894	1283287.KB822585_gene2646	7.8e-80	303.9	Propionibacteriales	scpA			ko:K05896					ko00000,ko03036				Bacteria	2GN1U@201174,4DMYR@85009,COG1354@1,COG1354@2	NA|NA|NA	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MAG.T12.45_00895	351607.Acel_1240	1.7e-104	386.0	Frankiales	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944		ko:K03496					ko00000,ko03036,ko04812				Bacteria	2GJX3@201174,4ERYA@85013,COG1192@1,COG1192@2	NA|NA|NA	D	PFAM Cobyrinic acid a,c-diamide synthase
MAG.T12.45_00896	1120950.KB892767_gene5149	3.8e-104	384.8	Propionibacteriales	xerD	GO:0008150,GO:0040007		ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	2GNDP@201174,4DNSC@85009,COG4974@1,COG4974@2	NA|NA|NA	L	tyrosine recombinase
MAG.T12.45_00897	219305.MCAG_04961	5.5e-158	563.9	Micromonosporales	ald		1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100		R00396	RC00008	ko00000,ko00001,ko01000				Bacteria	2GJ6G@201174,4DA3S@85008,COG0686@1,COG0686@2	NA|NA|NA	C	Belongs to the AlaDH PNT family
MAG.T12.45_00898	1177594.MIC448_2500030	5.3e-40	171.0	Microbacteriaceae	nudF		3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000				Bacteria	2GNW6@201174,4FNIB@85023,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T12.45_00899	471852.Tcur_2836	1.1e-260	905.6	Streptosporangiales	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377	Bacteria	2GJ13@201174,4EFKB@85012,COG0504@1,COG0504@2	NA|NA|NA	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MAG.T12.45_00900	66875.JODY01000020_gene275	6.2e-132	478.0	Actinobacteria	recN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360		ko:K03631,ko:K13582	ko04112,map04112				ko00000,ko00001,ko03400				Bacteria	2GIVG@201174,COG0497@1,COG0497@2	NA|NA|NA	L	May be involved in recombinational repair of damaged DNA
MAG.T12.45_00901	1048339.KB913029_gene4067	4.8e-96	357.8	Frankiales	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100		R00104	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	2GKM2@201174,4ERHI@85013,COG0061@1,COG0061@2	NA|NA|NA	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MAG.T12.45_00902	479433.Caci_5431	4.7e-87	327.8	Actinobacteria	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442					ko00000,ko01000,ko03009				Bacteria	2GJVT@201174,COG1189@1,COG1189@2	NA|NA|NA	J	Ribosomal RNA methyltransferase RrmJ FtsJ
MAG.T12.45_00904	1385521.N803_02695	1.8e-153	549.7	Intrasporangiaceae	uvrD		3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKRW@201174,4FFFK@85021,COG0210@1,COG0210@2	NA|NA|NA	L	DNA helicase
MAG.T12.45_00905	1048339.KB913029_gene2928	5.5e-157	560.8	Frankiales													Bacteria	2GJQ6@201174,4ES31@85013,COG0661@1,COG0661@2	NA|NA|NA	S	PFAM ABC-1 domain protein
MAG.T12.45_00906	1504319.GM45_1925	1.6e-15	87.8	Actinobacteria													Bacteria	2E479@1,2GQXY@201174,32Z35@2	NA|NA|NA		
MAG.T12.45_00907	479433.Caci_7935	7.7e-70	270.8	Actinobacteria			4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	2I7QX@201174,COG1024@1,COG1024@2	NA|NA|NA	I	Belongs to the enoyl-CoA hydratase isomerase family
MAG.T12.45_00908	1394178.AWOO02000039_gene8628	1.4e-30	139.8	Streptosporangiales	nudJ			ko:K12152					ko00000,ko01000				Bacteria	2GU6D@201174,4EIW9@85012,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T12.45_00909	58123.JOFJ01000003_gene2296	7.9e-117	427.6	Streptosporangiales													Bacteria	2GJ9K@201174,4EFYY@85012,COG5282@1,COG5282@2	NA|NA|NA	S	Zincin-like metallopeptidase
MAG.T12.45_00910	2002.JOEQ01000007_gene1821	2.5e-68	266.2	Streptosporangiales	lon			ko:K07177	ko02024,map02024				ko00000,ko00001,ko01002				Bacteria	2GJDD@201174,4EFR5@85012,COG3480@1,COG3480@2	NA|NA|NA	T	Lon protease (S16) C-terminal proteolytic domain
MAG.T12.45_00911	47716.JOFH01000006_gene1658	2.1e-35	155.6	Actinobacteria													Bacteria	2DA1Q@1,2GKR3@201174,32TUF@2	NA|NA|NA		
MAG.T12.45_00912	1283299.AUKG01000001_gene3535	2.6e-38	166.0	Rubrobacteria	apbE		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	2GN6F@201174,4CSHI@84995,COG1477@1,COG1477@2	NA|NA|NA	H	ApbE family
MAG.T12.45_00913	1048339.KB913029_gene2939	8.5e-280	969.9	Frankiales		GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K09118					ko00000				Bacteria	2GMP3@201174,4ERVJ@85013,COG1615@1,COG1615@2	NA|NA|NA	S	Uncharacterised protein family (UPF0182)
MAG.T12.45_00914	931627.MycrhDRAFT_2049	1.6e-171	609.4	Mycobacteriaceae				ko:K03294,ko:K03758					ko00000,ko02000	2.A.3.2			Bacteria	23D1J@1762,2H2J4@201174,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T12.45_00915	1449976.KALB_791	4.9e-40	172.2	Pseudonocardiales			3.1.1.85	ko:K02170,ko:K06889	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMK3@201174,4E10C@85010,COG1073@1,COG1073@2	NA|NA|NA	S	Prolyl oligopeptidase family
MAG.T12.45_00916	1146883.BLASA_4759	1.4e-66	260.0	Frankiales													Bacteria	2GKVT@201174,4EWMM@85013,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T12.45_00917	1128421.JAGA01000002_gene560	3.9e-22	112.1	unclassified Bacteria			3.5.1.106	ko:K15357	ko00760,ko01120,map00760,map01120	M00622	R09126	RC00323,RC02431	ko00000,ko00001,ko00002,ko01000				Bacteria	2NQB7@2323,COG2267@1,COG2267@2	NA|NA|NA	I	Alpha/beta hydrolase family
MAG.T12.45_00918	675635.Psed_2022	3e-79	302.0	Pseudonocardiales													Bacteria	2GKX1@201174,4E1RE@85010,COG1718@1,COG1718@2	NA|NA|NA	DT	Serine threonine protein kinase involved in cell cycle control
MAG.T12.45_00919	100226.SCO1348	2.5e-30	138.3	Actinobacteria													Bacteria	2CP0Z@1,2IHXV@201174,32SI8@2	NA|NA|NA	S	Protein of unknown function (DUF3037)
MAG.T12.45_00921	390989.JOEG01000008_gene1380	1.5e-48	198.7	Micromonosporales	gluA		3.6.3.21	ko:K02028,ko:K10008	ko02010,map02010	M00233,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.9			Bacteria	2GIZW@201174,4D8FR@85008,COG1126@1,COG1126@2	NA|NA|NA	E	ABC transporter
MAG.T12.45_00922	1122933.JNIY01000003_gene1070	1.2e-117	429.5	Cellulomonadaceae	gluB			ko:K10005	ko02010,map02010	M00233			ko00000,ko00001,ko00002,ko02000	3.A.1.3.9			Bacteria	2GJH8@201174,4F1V2@85016,COG0834@1,COG0834@2	NA|NA|NA	ET	Bacterial periplasmic substrate-binding proteins
MAG.T12.45_00923	1122933.JNIY01000003_gene1069	3.3e-78	298.1	Cellulomonadaceae	glnM	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K10006,ko:K10040	ko02010,map02010	M00228,M00233			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.9			Bacteria	2GNUR@201174,4F2G2@85016,COG0765@1,COG0765@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_00924	1122933.JNIY01000003_gene1068	5.2e-76	291.2	Cellulomonadaceae	gluD			ko:K02029,ko:K10007	ko02010,map02010	M00233,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.9			Bacteria	2GNBH@201174,4F29Z@85016,COG0765@1,COG0765@2	NA|NA|NA	E	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_00925	67275.JOAP01000018_gene1118	3.7e-18	100.1	Actinobacteria													Bacteria	2IBN6@201174,COG1502@1,COG1502@2	NA|NA|NA	I	PLD-like domain
MAG.T12.45_00926	656024.FsymDg_1517	0.0	1079.3	Frankiales				ko:K03727					ko00000,ko01000				Bacteria	2GJSV@201174,4ES27@85013,COG4581@1,COG4581@2	NA|NA|NA	L	DEAD DEAH box helicase
MAG.T12.45_00927	1394178.AWOO02000017_gene6765	6.9e-61	240.4	Streptosporangiales	galU	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509	2.7.7.9,5.4.2.8	ko:K00963,ko:K01840	ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130	M00114,M00129,M00361,M00362,M00549	R00289,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_1571,iHN637.CLJU_RS02205,iIT341.HP0646	Bacteria	2I2EW@201174,4EFN6@85012,COG1210@1,COG1210@2	NA|NA|NA	M	Nucleotidyl transferase
MAG.T12.45_00928	351607.Acel_0167	9e-106	390.6	Frankiales	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	2GJC3@201174,4ERWC@85013,COG0303@1,COG0303@2	NA|NA|NA	H	MoeA domain protein domain I and II
MAG.T12.45_00929	1123322.KB904676_gene3086	3e-60	238.4	Actinobacteria	rimJ		2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Bacteria	2HAFI@201174,COG1670@1,COG1670@2	NA|NA|NA	J	N-acetyltransferase
MAG.T12.45_00933	1112204.GPOL_c41030	6.2e-109	401.4	Gordoniaceae													Bacteria	2GKU0@201174,4GD5R@85026,COG1020@1,COG1020@2	NA|NA|NA	Q	Protein of unknown function (DUF1298)
MAG.T12.45_00934	1288083.AUKR01000009_gene1910	1.7e-84	319.7	Actinobacteria	pmt		2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100		R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003		GT39		Bacteria	2I2H1@201174,COG1928@1,COG1928@2	NA|NA|NA	O	PFAM glycosyl transferase family 39
MAG.T12.45_00937	1268303.RHODMAR_0244	6.7e-20	104.4	Nocardiaceae	copC			ko:K07156					ko00000,ko02000	9.B.62.2			Bacteria	2GMKG@201174,4FYGB@85025,COG2372@1,COG2372@2	NA|NA|NA	S	CopC domain
MAG.T12.45_00938	1121272.KB903249_gene2500	1.2e-63	249.2	Micromonosporales	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJHU@201174,4DB1U@85008,COG0173@1,COG0173@2	NA|NA|NA	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAG.T12.45_00939	1449347.JQLN01000007_gene1653	1e-46	194.5	Kitasatospora													Bacteria	2GKEJ@201174,2M1IE@2063,COG1432@1,COG1432@2	NA|NA|NA	S	NYN domain
MAG.T12.45_00940	1121017.AUFG01000001_gene2901	5.5e-27	127.5	Intrasporangiaceae													Bacteria	2IQMG@201174,4FHT2@85021,COG1714@1,COG1714@2	NA|NA|NA	S	PFAM RDD domain containing protein
MAG.T12.45_00942	479433.Caci_6340	7.8e-93	347.4	Actinobacteria													Bacteria	2GIRA@201174,COG4977@1,COG4977@2	NA|NA|NA	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain
MAG.T12.45_00943	1123319.AUBE01000003_gene975	1.6e-51	209.5	Actinobacteria		GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2AUFS@1,2GIXC@201174,31K3Y@2	NA|NA|NA	S	Domain of unknown function (DUF4191)
MAG.T12.45_00944	1077974.GOEFS_009_00220	9.9e-85	319.7	Gordoniaceae	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100		R07767,R07768	RC01978	ko00000,ko00001,ko01000				Bacteria	2GKD4@201174,4GBJ4@85026,COG0320@1,COG0320@2	NA|NA|NA	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MAG.T12.45_00945	585531.HMPREF0063_12534	4.2e-13	79.7	Propionibacteriales	namA		1.8.1.20	ko:K22347					ko00000,ko01000				Bacteria	2GK8E@201174,4DPKS@85009,COG1902@1,COG1902@2	NA|NA|NA	C	NADH:flavin oxidoreductase / NADH oxidase family
MAG.T12.45_00946	512565.AMIS_47840	5.5e-49	201.1	Bacteria			2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100		R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	COG0572@1,COG0572@2	NA|NA|NA	F	uridine kinase
MAG.T12.45_00947	1254432.SCE1572_09945	1.4e-70	274.6	Myxococcales													Bacteria	1QX82@1224,2X86M@28221,2Z3M6@29,43CYG@68525,COG5555@1,COG5555@2	NA|NA|NA	N	FG-GAP repeat
MAG.T12.45_00948	479431.Namu_1999	3.1e-44	184.9	Actinobacteria				ko:K06889					ko00000				Bacteria	2IPVI@201174,COG1073@1,COG1073@2	NA|NA|NA	S	X-Pro dipeptidyl-peptidase (S15 family)
MAG.T12.45_00952	1123320.KB889692_gene169	1.3e-105	390.2	Actinobacteria	nhaA			ko:K03313					ko00000,ko02000	2.A.33.1			Bacteria	2GKIK@201174,COG3004@1,COG3004@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MAG.T12.45_00953	1380356.JNIK01000011_gene1918	3e-13	82.0	Frankiales													Bacteria	2DPPE@1,2IN30@201174,332VJ@2,4ETAT@85013	NA|NA|NA	S	Putative Actinobacterial Holin-X, holin superfamily III
MAG.T12.45_00954	1123320.KB889692_gene167	1.5e-100	372.9	Actinobacteria													Bacteria	2I2IM@201174,COG2267@1,COG2267@2	NA|NA|NA	I	Alpha beta hydrolase
MAG.T12.45_00955	1122182.KB903835_gene4527	5.4e-47	195.3	Micromonosporales	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944											Bacteria	2GJ92@201174,4DA7U@85008,COG0265@1,COG0265@2	NA|NA|NA	O	Peptidase s1 and s6 chymotrypsin hap
MAG.T12.45_00956	1120950.KB892762_gene5484	3.3e-62	245.0	Propionibacteriales													Bacteria	2GKG9@201174,4DQJF@85009,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T12.45_00957	1120950.KB892762_gene5486	1.4e-90	339.3	Propionibacteriales	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJ01@201174,4DNJN@85009,COG0177@1,COG0177@2	NA|NA|NA	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MAG.T12.45_00958	351607.Acel_1994	2.2e-26	125.6	Frankiales													Bacteria	2AZUF@1,2HU1W@201174,31S3S@2,4EWGK@85013	NA|NA|NA		
MAG.T12.45_00959	105420.BBPO01000071_gene4051	3.4e-78	298.1	Streptacidiphilus	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141		ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	2GMPN@201174,2NFJS@228398,COG0664@1,COG0664@2	NA|NA|NA	T	helix_turn_helix, cAMP Regulatory protein
MAG.T12.45_00960	1504319.GM45_1285	2.9e-39	169.1	unclassified Actinobacteria (class)	pknE_1												Bacteria	2GKH8@201174,3UWV7@52018,COG1651@1,COG1651@2	NA|NA|NA	O	Thioredoxin
MAG.T12.45_00961	35754.JNYJ01000014_gene4756	1.1e-51	209.9	Micromonosporales													Bacteria	2GMVK@201174,4DD9S@85008,COG4243@1,COG4243@2	NA|NA|NA	S	VKc
MAG.T12.45_00962	469371.Tbis_1452	2.3e-81	308.9	Pseudonocardiales	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN6T@201174,4E01I@85010,COG0159@1,COG0159@2	NA|NA|NA	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MAG.T12.45_00963	1451261.AS96_10855	5.3e-148	530.4	Microbacteriaceae	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM7Z@201174,4FKK8@85023,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MAG.T12.45_00964	1283299.AUKG01000001_gene3305	5.7e-77	295.0	Actinobacteria			4.6.1.1	ko:K01768,ko:K17763	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021				Bacteria	2IIRA@201174,COG2200@1,COG2200@2,COG2203@1,COG2203@2	NA|NA|NA	T	PFAM EAL domain protein
MAG.T12.45_00965	1298863.AUEP01000012_gene3726	4.2e-54	218.4	Propionibacteriales	tsnR		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	2GJI6@201174,4DQ6Y@85009,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T12.45_00966	1307761.L21SP2_0103	1.4e-114	420.2	Spirochaetes		GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iLJ478.TM1840	Bacteria	2J6AH@203691,COG0366@1,COG0366@2	NA|NA|NA	G	PFAM Alpha amylase, catalytic domain
MAG.T12.45_00967	1123320.KB889667_gene2923	4.4e-168	597.4	Actinobacteria	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJGG@201174,COG0016@1,COG0016@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MAG.T12.45_00968	269800.Tfu_2060	1e-260	906.4	Streptosporangiales	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GMFD@201174,4EGYI@85012,COG0072@1,COG0072@2,COG0073@1,COG0073@2	NA|NA|NA	J	Ferredoxin-fold anticodon binding domain
MAG.T12.45_00969	1122963.AUHB01000006_gene2514	8.9e-35	154.1	Alphaproteobacteria													Bacteria	1N4Z9@1224,2UE0R@28211,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T12.45_00970	1123024.AUII01000002_gene940	5.5e-15	87.4	Pseudonocardiales													Bacteria	2I8IW@201174,4EF3K@85010,COG1846@1,COG1846@2	NA|NA|NA	K	helix_turn_helix multiple antibiotic resistance protein
MAG.T12.45_00971	1032480.MLP_44030	3.7e-171	608.2	Propionibacteriales													Bacteria	2H32P@201174,4DX0H@85009,COG0477@1,COG2814@2	NA|NA|NA	P	Fungal trichothecene efflux pump (TRI12)
MAG.T12.45_00972	351607.Acel_1263	1.9e-112	412.5	Frankiales	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKQK@201174,4ES9C@85013,COG0002@1,COG0002@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAG.T12.45_00973	1449353.JQMQ01000005_gene936	4.3e-145	521.2	Streptacidiphilus	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIW0@201174,2NEHP@228398,COG1364@1,COG1364@2	NA|NA|NA	E	ArgJ family
MAG.T12.45_00974	28042.GU90_13915	7.8e-110	403.7	Pseudonocardiales	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784	Bacteria	2GKDS@201174,4DXB3@85010,COG0548@1,COG0548@2	NA|NA|NA	E	Belongs to the acetylglutamate kinase family. ArgB subfamily
MAG.T12.45_00975	644283.Micau_2374	5e-128	464.5	Micromonosporales	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKE9@201174,4DBFJ@85008,COG4992@1,COG4992@2	NA|NA|NA	E	acetylornithine aminotransferase
MAG.T12.45_00976	1288083.AUKR01000003_gene3698	1.5e-43	182.6	Actinobacteria	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03402					ko00000,ko03000				Bacteria	2GKA5@201174,COG1438@1,COG1438@2	NA|NA|NA	K	Regulates arginine biosynthesis genes
MAG.T12.45_00977	1155718.KB891898_gene1918	7.5e-177	626.7	Actinobacteria	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147			iNJ661.Rv1658	Bacteria	2GK96@201174,COG0137@1,COG0137@2	NA|NA|NA	E	Belongs to the argininosuccinate synthase family. Type
MAG.T12.45_00978	1120950.KB892768_gene5196	1.7e-183	649.0	Propionibacteriales	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147			iJN678.argH	Bacteria	2GJ2A@201174,4DPEP@85009,COG0165@1,COG0165@2	NA|NA|NA	E	argininosuccinate lyase
MAG.T12.45_00979	1440053.JOEI01000018_gene518	1.3e-147	529.6	Actinobacteria	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJPR@201174,COG0162@1,COG0162@2	NA|NA|NA	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MAG.T12.45_00981	1150864.MILUP08_45615	1.6e-47	196.4	Micromonosporales			4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ0N@201174,4D9QW@85008,COG1024@1,COG1024@2	NA|NA|NA	I	enoyl-CoA hydratase
MAG.T12.45_00982	2002.JOEQ01000005_gene3278	5.6e-30	137.9	Streptosporangiales													Bacteria	2GP59@201174,4EQ00@85012,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_00984	1238182.C882_4443	1.9e-81	310.1	Rhodospirillales				ko:K06990,ko:K09141					ko00000,ko04812				Bacteria	1MXK5@1224,2JQVM@204441,2U13I@28211,COG1355@1,COG1355@2,COG2078@1,COG2078@2	NA|NA|NA	S	Belongs to the MEMO1 family
MAG.T12.45_00985	1415778.JQMM01000001_gene264	4.5e-152	544.3	unclassified Gammaproteobacteria	pflA		1.97.1.4	ko:K04069			R04710		ko00000,ko01000				Bacteria	1J9SI@118884,1NQC1@1224,1TH6D@1236,COG1180@1,COG1180@2	NA|NA|NA	O	Radical SAM superfamily
MAG.T12.45_00986	1120948.KB903247_gene4611	4.6e-68	265.4	Pseudonocardiales			6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIZP@201174,4DZTM@85010,COG4770@1,COG4770@2	NA|NA|NA	I	Acetyl propionyl-CoA carboxylase, alpha subunit
MAG.T12.45_00987	1380347.JNII01000008_gene4189	2.7e-51	208.8	Frankiales				ko:K10232	ko02010,map02010	M00201			ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8			Bacteria	2GJXB@201174,4ETQK@85013,COG1653@1,COG1653@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
MAG.T12.45_00988	1380347.JNII01000008_gene4188	2.9e-102	378.6	Frankiales	aglF			ko:K02025,ko:K10233,ko:K15771	ko02010,map02010	M00201,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.32,3.A.1.1.8			Bacteria	2GKYS@201174,4EV1G@85013,COG1175@1,COG1175@2	NA|NA|NA	G	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_00989	1380347.JNII01000008_gene4187	2.6e-97	362.1	Frankiales	aglG			ko:K02026,ko:K10234	ko02010,map02010	M00201,M00207			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8			Bacteria	2GJNN@201174,4EUW8@85013,COG0395@1,COG0395@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_00991	494419.ALPM01000043_gene2494	5.7e-21	108.2	Micrococcaceae			3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000		GH32		Bacteria	1WBZM@1268,2GJ9T@201174,COG1621@1,COG1621@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 32 family
MAG.T12.45_00992	1254432.SCE1572_10845	1.6e-155	556.6	Myxococcales	kup			ko:K03549					ko00000,ko02000	2.A.72			Bacteria	1MUVH@1224,2WJEH@28221,2YXPN@29,42P5Y@68525,COG3158@1,COG3158@2	NA|NA|NA	P	Transport of potassium into the cell
MAG.T12.45_00993	1283287.KB822581_gene1545	1.7e-23	117.1	Propionibacteriales			2.7.6.5	ko:K07816	ko00230,map00230		R00429	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	2GKF8@201174,4DPS6@85009,COG2357@1,COG2357@2,COG4328@1,COG4328@2	NA|NA|NA	Q	Region found in RelA / SpoT proteins
MAG.T12.45_00994	1108045.GORHZ_125_00320	9.8e-187	659.8	Gordoniaceae			6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	2GIUC@201174,4GBU2@85026,COG0318@1,COG0318@2	NA|NA|NA	IQ	AMP-binding enzyme C-terminal domain
MAG.T12.45_00995	1123322.KB904713_gene5220	1.8e-133	482.6	Actinobacteria			1.18.1.3,1.7.1.15	ko:K00362,ko:K00529	ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R02000,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJKT@201174,COG0446@1,COG0446@2	NA|NA|NA	Q	pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_00996	1121017.AUFG01000019_gene2370	1e-56	228.0	Intrasporangiaceae				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GIRE@201174,4FGR4@85021,COG1404@1,COG1404@2	NA|NA|NA	O	Subtilase family
MAG.T12.45_00997	1032480.MLP_04950	8.2e-53	214.2	Propionibacteriales	tagH		3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000				Bacteria	2I3RJ@201174,4DR7V@85009,COG3103@1,COG3103@2	NA|NA|NA	T	sh3 domain protein
MAG.T12.45_00998	1394178.AWOO02000021_gene7368	2.3e-32	144.8	Streptosporangiales	xth		3.1.11.2,6.5.1.1	ko:K01142,ko:K01971	ko03410,ko03450,map03410,map03450		R00381	RC00005	ko00000,ko00001,ko01000,ko03400				Bacteria	2GKEW@201174,4EGSA@85012,COG0708@1,COG0708@2	NA|NA|NA	L	Endonuclease/Exonuclease/phosphatase family
MAG.T12.45_00999	1121385.AQXW01000001_gene776	9.7e-57	226.9	Dermacoccaceae	yplQ			ko:K11068					ko00000,ko02042				Bacteria	1ZW8F@145357,2GJGQ@201174,COG1272@1,COG1272@2	NA|NA|NA	S	hemolysin III
MAG.T12.45_01000	1449355.JQNR01000005_gene3991	7.9e-100	370.2	Actinobacteria	uppS		2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110		R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006				Bacteria	2GJCP@201174,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAG.T12.45_01003	1304865.JAGF01000001_gene2260	2.7e-229	801.6	Actinobacteria	bglF			ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271			ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6			Bacteria	2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	Pts system
MAG.T12.45_01004	446471.Xcel_0116	4.8e-31	141.4	Promicromonosporaceae			5.4.2.12	ko:K15634,ko:K15640	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK2I@201174,4F5AK@85017,COG0406@1,COG0406@2	NA|NA|NA	G	Phosphoglycerate mutase family
MAG.T12.45_01005	1348663.KCH_12620	4.5e-189	667.5	Kitasatospora	guaC	GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147			iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102	Bacteria	2GNDC@201174,2M0KH@2063,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	IMP dehydrogenase / GMP reductase domain
MAG.T12.45_01008	1169161.KB897717_gene3159	1.6e-38	165.2	Actinobacteria	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112		ko:K02986	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GIRX@201174,COG0522@1,COG0522@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MAG.T12.45_01009	471852.Tcur_4290	5.8e-151	540.4	Streptosporangiales	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2GJJ5@201174,4EGUV@85012,COG0202@1,COG0202@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T12.45_01010	471853.Bcav_3112	4.2e-53	214.5	Actinobacteria	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904		ko:K02879	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHV2@201174,COG0203@1,COG0203@2	NA|NA|NA	J	ribosomal protein L17
MAG.T12.45_01011	1095767.CAHD01000130_gene1332	8e-80	303.9	Cellulomonadaceae	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173					ko00000,ko01000,ko03016				Bacteria	2GJ6C@201174,4F0W6@85016,COG0101@1,COG0101@2	NA|NA|NA	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MAG.T12.45_01012	1122138.AQUZ01000015_gene6722	6.7e-224	783.5	Propionibacteriales													Bacteria	2GMUD@201174,4DNQ6@85009,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_01013	269800.Tfu_0522	6.3e-25	120.2	Streptosporangiales	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	2.1.1.63	ko:K00567,ko:K07443					ko00000,ko01000,ko03400				Bacteria	2GQMD@201174,4EKN0@85012,COG3695@1,COG3695@2	NA|NA|NA	L	6-O-methylguanine DNA methyltransferase, DNA binding domain
MAG.T12.45_01014	1123321.KB905817_gene5166	1e-61	243.0	Actinobacteria	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02871	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFG1@201174,COG0102@1,COG0102@2	NA|NA|NA	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MAG.T12.45_01015	196162.Noca_4337	1.5e-113	416.0	Propionibacteriales	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945,ko:K03566	ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	2GK3H@201174,4DP92@85009,COG0152@1,COG0152@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T12.45_01016	105425.BBPL01000013_gene1809	4e-198	697.6	Streptacidiphilus	purB		4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKBR@201174,2NGEH@228398,COG0015@1,COG0015@2	NA|NA|NA	F	Adenylosuccinate lyase C-terminus
MAG.T12.45_01017	33876.JNXY01000025_gene5373	1.3e-41	176.0	Micromonosporales	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.3.1,6.3.4.13,6.3.5.3	ko:K01945,ko:K01952,ko:K11788,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208,R04463,R04591	RC00010,RC00064,RC00090,RC00162,RC00166,RC01100,RC01160	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530	Bacteria	2I2F5@201174,4D925@85008,COG0151@1,COG0151@2	NA|NA|NA	F	Belongs to the GARS family
MAG.T12.45_01018	1032480.MLP_27810	2.1e-19	101.3	Propionibacteriales	pfp		2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130		R00764,R02073	RC00017	ko00000,ko00001,ko01000				Bacteria	2GK6W@201174,4DPPT@85009,COG0205@1,COG0205@2	NA|NA|NA	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
MAG.T12.45_01019	471852.Tcur_2640	1.1e-179	636.3	Streptosporangiales	aroH		2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJBX@201174,4EGEY@85012,COG3200@1,COG3200@2	NA|NA|NA	E	Class-II DAHP synthetase family
MAG.T12.45_01021	1283283.ATXA01000003_gene1425	3.8e-113	414.8	Frankiales	ltaA		4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230		R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000				Bacteria	2GMNV@201174,4ERZD@85013,COG2008@1,COG2008@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T12.45_01022	479433.Caci_6006	1.8e-68	266.2	Actinobacteria	ydeD												Bacteria	2I8X5@201174,COG0697@1,COG0697@2	NA|NA|NA	EG	of the drug metabolite transporter (DMT) superfamily
MAG.T12.45_01023	397278.JOJN01000001_gene2592	1.5e-132	480.3	Propionibacteriales	pknL		2.7.11.1	ko:K12132					ko00000,ko01000,ko01001				Bacteria	2GJ1J@201174,4DPC3@85009,COG0515@1,COG0515@2,COG2815@1,COG2815@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T12.45_01027	994573.T472_0212005	4.7e-20	104.4	Clostridiaceae													Bacteria	1UFXJ@1239,25MXD@186801,2BIQB@1,32CXP@2,36T3P@31979	NA|NA|NA		
MAG.T12.45_01030	543632.JOJL01000036_gene3056	1.3e-27	130.2	Actinobacteria	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896		ko:K21687					ko00000		GH23		Bacteria	2GR94@201174,COG1652@1,COG1652@2,COG2247@1,COG2247@2	NA|NA|NA	M	D-alanyl-D-alanine carboxypeptidase
MAG.T12.45_01033	1137269.AZWL01000042_gene1229	4e-37	162.2	Actinobacteria													Bacteria	2DVVA@1,2IHH0@201174,32V07@2	NA|NA|NA		
MAG.T12.45_01034	1121372.AULK01000004_gene1325	1.2e-21	111.3	Microbacteriaceae													Bacteria	2GU7G@201174,4FMTP@85023,COG1403@1,COG1403@2	NA|NA|NA	V	Domain of unknown function (DUF222)
MAG.T12.45_01035	219305.MCAG_00437	5.8e-201	707.2	Micromonosporales	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJG0@201174,4DBW4@85008,COG0166@1,COG0166@2	NA|NA|NA	G	Belongs to the GPI family
MAG.T12.45_01036	446468.Ndas_1544	2.7e-114	418.7	Streptosporangiales	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iNJ661.Rv2130c	Bacteria	2GJZR@201174,4EH1Y@85012,COG0215@1,COG0215@2	NA|NA|NA	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins
MAG.T12.45_01037	1380356.JNIK01000018_gene799	1.6e-94	352.4	Frankiales													Bacteria	2GIZB@201174,4ERG0@85013,COG0745@1,COG0745@2	NA|NA|NA	T	Two component transcriptional regulator, winged helix family
MAG.T12.45_01038	1435356.Y013_11045	1.5e-95	357.1	Nocardiaceae	phoR		2.7.13.3	ko:K02484,ko:K07768	ko02020,map02020	M00443			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2I2DU@201174,4FTXC@85025,COG5002@1,COG5002@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T12.45_01039	1394178.AWOO02000024_gene5655	7.8e-27	128.6	Streptosporangiales													Bacteria	2HV9N@201174,4EINQ@85012,COG5555@1,COG5555@2	NA|NA|NA	N	Belongs to the peptidase S8 family
MAG.T12.45_01040	1121946.AUAX01000005_gene5163	8.1e-59	234.6	Micromonosporales													Bacteria	2GIR7@201174,4D95J@85008,COG4129@1,COG4129@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T12.45_01041	479431.Namu_0355	9.7e-10	68.2	Actinobacteria													Bacteria	2EGTM@1,2GWY1@201174,33AJR@2	NA|NA|NA		
MAG.T12.45_01042	446465.Bfae_27530	6.4e-78	298.1	Dermabacteraceae	yqhO	GO:0003674,GO:0003824,GO:0016787		ko:K07001					ko00000				Bacteria	2IA6V@201174,4FC03@85020,COG1752@1,COG1752@2	NA|NA|NA	S	Patatin-like phospholipase
MAG.T12.45_01043	1304865.JAGF01000001_gene3499	2.2e-102	379.0	Actinobacteria	corA			ko:K03284					ko00000,ko02000	1.A.35.1,1.A.35.3			Bacteria	2IB0N@201174,COG0598@1,COG0598@2	NA|NA|NA	P	PFAM Mg2 transporter protein CorA family protein
MAG.T12.45_01044	1463903.JOIZ01000010_gene3653	1.1e-52	213.4	Actinobacteria													Bacteria	2GJ2N@201174,COG0745@1,COG0745@2	NA|NA|NA	T	response regulator, receiver
MAG.T12.45_01045	1304865.JAGF01000001_gene2387	9e-34	150.6	Actinobacteria													Bacteria	2GJKC@201174,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_01048	68170.KL590469_gene1813	8.4e-23	113.6	Pseudonocardiales			1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GJP5@201174,4E3JM@85010,COG0377@1,COG0377@2	NA|NA|NA	C	NADH ubiquinone oxidoreductase, 20 Kd subunit
MAG.T12.45_01049	644283.Micau_5568	9.5e-22	110.2	Micromonosporales	nuoC2		1.6.5.3	ko:K00332,ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GNVP@201174,4DBTZ@85008,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MAG.T12.45_01050	1051006.HMPREF1162_1975	2.1e-27	128.3	Actinobacteria	nuoI		1.6.5.3	ko:K00338,ko:K03615,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GPSS@201174,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_01051	411471.SUBVAR_05270	2.1e-48	199.1	Ruminococcaceae	pgp	GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564	3.1.3.18	ko:K01091,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	1V1FQ@1239,24G1U@186801,3WITI@541000,COG0546@1,COG0546@2	NA|NA|NA	S	Psort location Cytoplasmic, score
MAG.T12.45_01052	1041522.MCOL_V200460	2.2e-58	231.9	Mycobacteriaceae	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K09767					ko00000				Bacteria	232N6@1762,2IFIU@201174,COG1666@1,COG1666@2	NA|NA|NA	S	Belongs to the UPF0234 family
MAG.T12.45_01056	219305.MCAG_00089	5.3e-201	707.6	Micromonosporales	ydaO												Bacteria	2GK5V@201174,4DI99@85008,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T12.45_01057	196162.Noca_1085	3.4e-172	611.7	Propionibacteriales	modB		2.1.1.72	ko:K00571,ko:K07316					ko00000,ko01000,ko02048				Bacteria	2I8FH@201174,4DTYW@85009,COG2189@1,COG2189@2	NA|NA|NA	L	DNA methylase
MAG.T12.45_01058	861360.AARI_08090	1.5e-45	189.5	Actinobacteria	pin	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360											Bacteria	2HSUX@201174,COG1961@1,COG1961@2	NA|NA|NA	L	Site-specific recombinases, DNA invertase Pin homologs
MAG.T12.45_01060	1157943.KB892705_gene2163	1.5e-62	245.7	Mycobacteriaceae	istB												Bacteria	234SX@1762,2H714@201174,COG1484@1,COG1484@2	NA|NA|NA	L	IstB-like ATP binding protein
MAG.T12.45_01061	479431.Namu_1217	5.7e-45	187.2	Actinobacteria													Bacteria	29RW6@1,2IFWT@201174,30D09@2	NA|NA|NA		
MAG.T12.45_01062	479431.Namu_1216	1.1e-279	969.1	Actinobacteria													Bacteria	2I8Z3@201174,COG0582@1,COG0582@2	NA|NA|NA	L	integrase family
MAG.T12.45_01063	101510.RHA1_ro06981	3.7e-165	587.8	Nocardiaceae	resD			ko:K04763					ko00000,ko03036				Bacteria	2I45W@201174,4G9K9@85025,COG0582@1,COG0582@2	NA|NA|NA	L	Phage integrase, N-terminal SAM-like domain
MAG.T12.45_01064	391037.Sare_2910	2.7e-61	241.9	Actinobacteria													Bacteria	2C7PT@1,2I886@201174,2ZCBY@2	NA|NA|NA		
MAG.T12.45_01065	1133849.O3I_037875	3.1e-59	235.3	Nocardiaceae													Bacteria	2HH54@201174,4G3S3@85025,COG1309@1,COG1309@2	NA|NA|NA	K	Tetracyclin repressor, C-terminal all-alpha domain
MAG.T12.45_01066	765420.OSCT_0070	2.8e-38	165.6	Chloroflexia													Bacteria	28IZQ@1,2GA1E@200795,2Z8X1@2,377NY@32061	NA|NA|NA	S	Domain of unknown function (DUF4386)
MAG.T12.45_01067	526225.Gobs_1399	9.3e-77	293.1	Frankiales				ko:K19689					ko00000,ko01000,ko01002				Bacteria	2GJT9@201174,4ETFJ@85013,COG0640@1,COG0640@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T12.45_01068	1380370.JIBA01000010_gene2372	3.7e-116	424.5	Bacteria													Bacteria	COG3832@1,COG3832@2	NA|NA|NA	J	glyoxalase III activity
MAG.T12.45_01069	935866.JAER01000004_gene3859	6.6e-36	156.4	Propionibacteriales													Bacteria	2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009	NA|NA|NA	S	Domain of unknown function (DUF4287)
MAG.T12.45_01070	196162.Noca_2810	1e-84	319.7	Propionibacteriales	MA20_05015												Bacteria	2IHPD@201174,4DWVV@85009,COG0500@1,COG2226@2	NA|NA|NA	Q	Methyltransferase domain
MAG.T12.45_01071	1035308.AQYY01000001_gene3477	7.2e-22	109.4	Bacteria													Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
MAG.T12.45_01073	67352.JODS01000001_gene448	2.1e-105	389.0	Actinobacteria	yeaC			ko:K03924					ko00000,ko01000				Bacteria	2GK07@201174,COG0714@1,COG0714@2	NA|NA|NA	S	associated with various cellular activities
MAG.T12.45_01074	1463936.JOJI01000017_gene7472	7.2e-45	188.3	Actinobacteria													Bacteria	2GIWE@201174,COG1721@1,COG1721@2	NA|NA|NA	J	protein some members contain a von Willebrand factor type A vWA domain
MAG.T12.45_01079	405948.SACE_3492	1.2e-100	373.2	Pseudonocardiales	MA20_17565												Bacteria	2GNZT@201174,4DZ7M@85010,COG0265@1,COG0265@2	NA|NA|NA	O	C-terminal PDZ domain
MAG.T12.45_01080	1540221.JQNI01000002_gene2504	2.7e-42	177.9	Deinococcus-Thermus													Bacteria	1WKYF@1297,COG1028@1,COG1028@2	NA|NA|NA	IQ	PFAM short chain dehydrogenase
MAG.T12.45_01081	1380347.JNII01000005_gene2849	3e-49	201.8	Frankiales				ko:K10947					ko00000,ko03000				Bacteria	2IFDN@201174,4ET5U@85013,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01082	469371.Tbis_0943	7.5e-72	276.9	Pseudonocardiales	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100		R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011				Bacteria	2GM2B@201174,4E0TE@85010,COG0127@1,COG0127@2	NA|NA|NA	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MAG.T12.45_01083	266940.Krad_3763	2.2e-94	352.1	Actinobacteria	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016				Bacteria	2GJFI@201174,COG0689@1,COG0689@2	NA|NA|NA	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MAG.T12.45_01084	1394178.AWOO02000078_gene2041	5e-70	271.2	Streptosporangiales	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267											Bacteria	2GMEX@201174,4EIG9@85012,COG1234@1,COG1234@2	NA|NA|NA	S	Beta-lactamase superfamily domain
MAG.T12.45_01085	1146883.BLASA_1169	9.8e-99	366.7	Frankiales	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100		R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011			iYO844.BSU28390	Bacteria	2GN4I@201174,4ERE1@85013,COG0796@1,COG0796@2	NA|NA|NA	M	Provides the (R)-glutamate required for cell wall biosynthesis
MAG.T12.45_01086	1206732.BAGD01000097_gene4238	2.8e-32	145.6	Nocardiaceae													Bacteria	2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2	NA|NA|NA	E	Serine aminopeptidase, S33
MAG.T12.45_01088	1043493.BBLU01000002_gene1838	5.7e-31	141.4	Bacteria				ko:K16129	ko01054,map01054				ko00000,ko00001,ko01008				Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T12.45_01090	1169152.AXVD01000023_gene3257	4.9e-15	88.2	Nocardiaceae	ydiN			ko:K03762					ko00000,ko02000	2.A.1.6.4			Bacteria	2HHY4@201174,4G1MV@85025,COG0477@1,COG0477@2,COG0500@1,COG2226@2	NA|NA|NA	Q	Mycolic acid cyclopropane synthetase
MAG.T12.45_01092	106370.Francci3_4302	9.3e-21	106.3	Frankiales	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K04749					ko00000,ko03021				Bacteria	2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2	NA|NA|NA	T	Belongs to the anti-sigma-factor antagonist family
MAG.T12.45_01093	47716.JOFH01000021_gene4179	4e-15	87.8	Actinobacteria			2.7.11.1	ko:K04757					ko00000,ko01000,ko01001,ko03021				Bacteria	2IHNR@201174,COG2172@1,COG2172@2	NA|NA|NA	T	anti-sigma regulatory factor
MAG.T12.45_01097	1122609.AUGT01000013_gene4182	3.2e-169	601.3	Propionibacteriales	pccB		2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIRU@201174,4DNBQ@85009,COG4799@1,COG4799@2	NA|NA|NA	I	Carboxyl transferase domain
MAG.T12.45_01099	1298860.AUEM01000003_gene3722	2.2e-17	97.8	Microbacteriaceae			2.4.1.52	ko:K00712					ko00000,ko01000,ko01003		GT4		Bacteria	2GJBP@201174,4FNSK@85023,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T12.45_01100	2074.JNYD01000012_gene432	3.6e-48	198.4	Pseudonocardiales	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	1.1.1.25,2.1.1.190	ko:K00014,ko:K03215,ko:K06287	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2GNI0@201174,4E2ME@85010,COG0424@1,COG0424@2	NA|NA|NA	D	Maf-like protein
MAG.T12.45_01101	1122138.AQUZ01000019_gene8156	3.5e-38	165.6	Propionibacteriales													Bacteria	2GN53@201174,4DRB6@85009,COG4447@1,COG4447@2	NA|NA|NA	S	cellulose binding
MAG.T12.45_01102	313589.JNB_01175	1.4e-33	149.8	Intrasporangiaceae													Bacteria	2IKUE@201174,4FGXY@85021,COG3544@1,COG3544@2	NA|NA|NA	S	Domain of unknown function (DUF4142)
MAG.T12.45_01103	223184.AS25_05575	2.5e-142	512.3	Micrococcaceae													Bacteria	1W8P3@1268,2GMJ4@201174,COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T12.45_01105	1240349.ANGC01000011_gene329	4e-77	294.7	Nocardiaceae													Bacteria	2GK5S@201174,4G8SS@85025,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T12.45_01107	1386089.N865_03210	1.2e-83	316.2	Actinobacteria				ko:K07487					ko00000				Bacteria	2HW75@201174,COG3039@1,COG3039@2,COG3547@1,COG3547@2	NA|NA|NA	L	PFAM transposase, IS4 family protein
MAG.T12.45_01109	1150399.AQYK01000002_gene2758	1.5e-38	166.0	Microbacteriaceae	yaeJ			ko:K02835,ko:K15034					ko00000,ko03012				Bacteria	2I7Z4@201174,4FPEN@85023,COG0216@1,COG0216@2	NA|NA|NA	J	RF-1 domain
MAG.T12.45_01110	266940.Krad_1202	8.2e-08	64.3	Bacteria				ko:K15383					ko00000,ko02000	9.A.58.2			Bacteria	COG4095@1,COG4095@2	NA|NA|NA	S	Sugar efflux transporter for intercellular exchange
MAG.T12.45_01111	1033730.CAHG01000004_gene3	2.2e-59	235.3	Propionibacteriales	adk		2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJ7T@201174,4DP2T@85009,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MAG.T12.45_01112	1510531.JQJJ01000008_gene4215	3.4e-156	558.5	Bradyrhizobiaceae	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03455					ko00000	2.A.37			Bacteria	1MV34@1224,2TRC5@28211,3JVBN@41294,COG1226@1,COG1226@2,COG4651@1,COG4651@2	NA|NA|NA	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MAG.T12.45_01114	1429046.RR21198_0487	9.6e-74	284.3	Nocardiaceae	gcd												Bacteria	2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2	NA|NA|NA	G	Glucose / Sorbosone dehydrogenase
MAG.T12.45_01115	762948.HMPREF0733_10179	1.1e-13	82.4	Micrococcaceae													Bacteria	1WAB6@1268,2IQY7@201174,COG2261@1,COG2261@2	NA|NA|NA	S	Transglycosylase associated protein
MAG.T12.45_01116	394.NGR_c28520	2.8e-182	644.8	Rhizobiaceae	arcA		3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130		R00552	RC00177	ko00000,ko00001,ko01000				Bacteria	1NCGV@1224,2TU0Z@28211,4BAQ4@82115,COG2235@1,COG2235@2	NA|NA|NA	E	Arginine
MAG.T12.45_01117	66377.JOBH01000008_gene6677	1.7e-38	166.0	Actinobacteria	pfs		3.2.2.1,3.2.2.9	ko:K01239,ko:K01243	ko00230,ko00270,ko00760,ko01100,ko01230,map00230,map00270,map00760,map01100,map01230	M00034,M00609	R00194,R01245,R01273,R01401,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko00002,ko01000				Bacteria	2IMZ7@201174,COG0775@1,COG0775@2	NA|NA|NA	F	nucleosidase
MAG.T12.45_01118	1206725.BAFU01000044_gene2179	2.7e-56	226.5	Nocardiaceae			2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2HEI2@201174,4FV0Z@85025,COG2199@1,COG2199@2,COG5000@1,COG5000@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_01119	366602.Caul_2877	1.3e-64	253.4	Alphaproteobacteria	yceM		1.1.1.18,1.1.1.369	ko:K00010,ko:K03810	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130		R01183,R09951	RC00182	ko00000,ko00001,ko01000				Bacteria	1MVCX@1224,2UQ6G@28211,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, NAD-binding Rossmann fold
MAG.T12.45_01120	1894.JOER01000006_gene836	1.5e-10	73.2	Actinobacteria			3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100		R02778	RC00017	ko00000,ko00001,ko01000				Bacteria	2IKKW@201174,COG1877@1,COG1877@2	NA|NA|NA	G	trehalose-phosphatase activity
MAG.T12.45_01121	196162.Noca_2635	8.9e-57	226.9	Propionibacteriales													Bacteria	2GJKM@201174,4DQZM@85009,COG2197@1,COG2197@2	NA|NA|NA	T	helix_turn_helix, Lux Regulon
MAG.T12.45_01122	1172188.KB911825_gene3704	2.3e-72	279.6	Intrasporangiaceae													Bacteria	2IAG1@201174,4FEJ3@85021,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_01123	1298863.AUEP01000005_gene2350	8.5e-21	106.7	Propionibacteriales													Bacteria	2CEFP@1,2GT06@201174,2ZGIZ@2,4DVNV@85009	NA|NA|NA		
MAG.T12.45_01124	1869.MB27_19770	2.2e-87	328.9	Micromonosporales	ppgK		2.7.1.2,2.7.1.63,5.3.1.9	ko:K00845,ko:K00886,ko:K01810	ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114,M00549	R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321	RC00002,RC00017,RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJA0@201174,4DCFF@85008,COG1940@1,COG1940@2	NA|NA|NA	GK	ROK family
MAG.T12.45_01125	1121926.AXWO01000013_gene2101	9e-55	220.7	Glycomycetales	ytnM			ko:K07090					ko00000				Bacteria	2GNPE@201174,4EZI4@85014,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T12.45_01126	420662.Mpe_A3085	7.7e-23	112.8	unclassified Burkholderiales	dbi		1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000				Bacteria	1KM9E@119065,1MZPP@1224,2VUK0@28216,COG4281@1,COG4281@2	NA|NA|NA	I	acyl-coA-binding protein
MAG.T12.45_01128	471852.Tcur_0658	2.5e-79	302.0	Streptosporangiales			2.3.1.247	ko:K18013	ko00310,map00310		R10564	RC02728,RC03199	ko00000,ko00001,ko01000				Bacteria	2I9EQ@201174,4EKG1@85012,COG3246@1,COG3246@2	NA|NA|NA	S	beta-keto acid cleavage enzyme
MAG.T12.45_01129	1155714.KB891993_gene5428	4.3e-79	301.6	Actinobacteria	ansA		3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110		R00485	RC00010,RC02798	ko00000,ko00001,ko01000				Bacteria	2GJA7@201174,COG4448@1,COG4448@2	NA|NA|NA	E	L-asparaginase II
MAG.T12.45_01131	351607.Acel_0067	4.3e-33	147.5	Frankiales	clgR_2	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Bacteria	2IKVI@201174,4ET27@85013,COG1396@1,COG1396@2	NA|NA|NA	K	transcriptional regulator, XRE family
MAG.T12.45_01132	1206733.BAGC01000061_gene3397	1.3e-15	89.0	Nocardiaceae													Bacteria	2EHMU@1,2HM2W@201174,33BDI@2,4G3KX@85025	NA|NA|NA	S	Protein of unknown function (DUF2516)
MAG.T12.45_01133	356851.JOAN01000015_gene2702	7.1e-81	307.4	Micromonosporales			2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK2F@201174,4D8DF@85008,COG4122@1,COG4122@2	NA|NA|NA	S	O-methyltransferase activity
MAG.T12.45_01134	1169161.KB897717_gene2918	2.8e-162	578.2	Actinobacteria	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32,4.1.1.49	ko:K01596,ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003,M00170	R00341,R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2638	Bacteria	2GJH3@201174,COG1274@1,COG1274@2	NA|NA|NA	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
MAG.T12.45_01135	1380356.JNIK01000015_gene2347	4.9e-116	424.5	Frankiales	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410	Bacteria	2GJ6H@201174,4ERRI@85013,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MAG.T12.45_01136	1306174.JODP01000018_gene4493	2.2e-23	115.2	Actinobacteria	wblB			ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQS5@201174,32S23@2	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T12.45_01137	223184.AS25_09540	2.1e-26	124.8	Micrococcaceae													Bacteria	1W9TC@1268,2CAFG@1,2IQ98@201174,32RRB@2	NA|NA|NA	S	Protein of unknown function (DUF3039)
MAG.T12.45_01138	1463920.JOGB01000039_gene946	6.2e-23	113.6	Actinobacteria	prmC		2.1.1.297	ko:K02493			R10806	RC00003,RC03279	ko00000,ko01000,ko03012				Bacteria	2GNC1@201174,COG2890@1,COG2890@2	NA|NA|NA	J	Belongs to the protein N5-glutamine methyltransferase family
MAG.T12.45_01139	1313172.YM304_16100	2.9e-52	213.4	Actinobacteria													Bacteria	2HZ7I@201174,COG3858@1,COG3858@2	NA|NA|NA	S	Glycosyl hydrolases family 18
MAG.T12.45_01140	471852.Tcur_3874	4e-29	134.8	Streptosporangiales													Bacteria	2E4AX@1,2GW4T@201174,32Z6K@2,4EJ1I@85012	NA|NA|NA	S	Domain of unknown function (DUF2017)
MAG.T12.45_01141	1120950.KB892709_gene4055	2.4e-33	147.9	Propionibacteriales	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087		ko:K06891					ko00000				Bacteria	2IQ3Z@201174,4DRQZ@85009,COG2127@1,COG2127@2	NA|NA|NA	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MAG.T12.45_01142	1111729.ATYV01000023_gene1471	6.3e-50	204.1	Corynebacteriaceae	coaE	GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464	2.7.1.24	ko:K00859,ko:K02096,ko:K02286,ko:K02290,ko:K02630,ko:K05378,ko:K05379,ko:K05380	ko00196,ko00770,ko01100,map00196,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko00194,ko01000				Bacteria	22MZB@1653,2GN96@201174,COG0237@1,COG0237@2	NA|NA|NA	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MAG.T12.45_01143	479435.Kfla_3091	3.2e-32	146.4	Propionibacteriales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJV2@201174,4DQVU@85009,COG2244@1,COG2244@2	NA|NA|NA	S	polysaccharide biosynthetic process
MAG.T12.45_01144	1283287.KB822576_gene3718	1.3e-145	522.7	Propionibacteriales	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K02945	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJAK@201174,4DPIM@85009,COG0539@1,COG0539@2	NA|NA|NA	J	ribosomal protein
MAG.T12.45_01145	1032480.MLP_13020	3.6e-43	181.4	Propionibacteriales													Bacteria	2GNA1@201174,4DRXP@85009,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator PadR-like family
MAG.T12.45_01146	1125971.ASJB01000080_gene7628	6.2e-65	254.2	Pseudonocardiales	lolD			ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GM25@201174,4DXIQ@85010,COG1136@1,COG1136@2	NA|NA|NA	V	ABC-type antimicrobial peptide transport system, ATPase component
MAG.T12.45_01147	1033730.CAHG01000016_gene217	4.4e-32	146.0	Propionibacteriales													Bacteria	2HZH5@201174,4DSSV@85009,COG0577@1,COG0577@2	NA|NA|NA	V	efflux transmembrane transporter activity
MAG.T12.45_01148	1449069.JMLO01000001_gene1935	9.2e-105	386.3	Nocardiaceae													Bacteria	2GMUG@201174,4FZ08@85025,COG2197@1,COG2197@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T12.45_01149	1449069.JMLO01000001_gene1936	8e-165	586.6	Nocardiaceae													Bacteria	2GS7K@201174,4G082@85025,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_01150	469383.Cwoe_0678	2.8e-58	231.5	Rubrobacteria													Bacteria	2ICAF@201174,313GU@2,4CQYQ@84995,arCOG06733@1	NA|NA|NA		
MAG.T12.45_01151	1306174.JODP01000001_gene4819	1.2e-19	104.8	Bacteria													Bacteria	COG5555@1,COG5555@2	NA|NA|NA		
MAG.T12.45_01152	105420.BBPO01000020_gene5614	5.7e-217	760.4	Streptacidiphilus			3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Bacteria	2IA3D@201174,2NI27@228398,COG3119@1,COG3119@2	NA|NA|NA	P	Sulfatase
MAG.T12.45_01153	1192034.CAP_5004	4.7e-23	114.4	Myxococcales													Bacteria	1NBEP@1224,2E4IQ@1,2WW82@28221,2YVWC@29,32ZDS@2,431T4@68525	NA|NA|NA		
MAG.T12.45_01154	1385518.N798_03110	2e-23	115.5	Intrasporangiaceae													Bacteria	2DRYE@1,2IS24@201174,33DPC@2,4FHPE@85021	NA|NA|NA		
MAG.T12.45_01155	351607.Acel_0550	1.1e-158	566.2	Frankiales	pilT			ko:K02669					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	2HPWY@201174,4EUA1@85013,COG2805@1,COG2805@2	NA|NA|NA	NU	Type II/IV secretion system protein
MAG.T12.45_01156	68194.JNXR01000016_gene7360	9.4e-20	103.2	Actinobacteria													Bacteria	2IKZP@201174,COG5496@1,COG5496@2	NA|NA|NA	S	Thioesterase
MAG.T12.45_01157	1123320.KB889733_gene6240	4e-102	378.3	Actinobacteria			2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002				Bacteria	2GP4W@201174,COG0449@1,COG0449@2	NA|NA|NA	M	PFAM Sugar isomerase (SIS)
MAG.T12.45_01158	28444.JODQ01000015_gene1617	1.4e-100	373.6	Streptosporangiales	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936		M00839			ko00000,ko00002,ko01000,ko01001,ko02022				Bacteria	2GKMP@201174,4EG9F@85012,COG3920@1,COG3920@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_01159	1283283.ATXA01000002_gene2799	5.9e-36	156.4	Frankiales	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K18955					ko00000,ko03000				Bacteria	2DMIE@1,2IQCG@201174,32RSG@2,4ET35@85013	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T12.45_01160	1123320.KB889737_gene5367	1.1e-70	273.9	Actinobacteria													Bacteria	2GJ3K@201174,COG1597@1,COG1597@2	NA|NA|NA	I	Diacylglycerol kinase
MAG.T12.45_01162	222534.KB893670_gene3630	1.1e-89	337.0	Frankiales	sigB	GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03090					ko00000,ko03021				Bacteria	2GKSY@201174,4ES7X@85013,COG1191@1,COG1191@2	NA|NA|NA	K	RNA polymerase
MAG.T12.45_01163	500153.JOEK01000002_gene442	4e-23	114.4	Actinobacteria	rshA		2.7.11.1	ko:K04757					ko00000,ko01000,ko01001,ko03021				Bacteria	2IFG9@201174,COG2172@1,COG2172@2	NA|NA|NA	T	anti-sigma regulatory factor
MAG.T12.45_01164	926550.CLDAP_32320	1.6e-34	151.8	Chloroflexi			1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	2G6PM@200795,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T12.45_01165	1283283.ATXA01000002_gene2609	4.5e-47	194.1	Frankiales	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15540	Bacteria	2GKC6@201174,4ERIP@85013,COG0167@1,COG0167@2	NA|NA|NA	F	Catalyzes the conversion of dihydroorotate to orotate
MAG.T12.45_01166	367299.JOEE01000005_gene3472	4.1e-97	361.3	Intrasporangiaceae	pyrK			ko:K02823	ko00240,ko01100,map00240,map01100				ko00000,ko00001				Bacteria	2HQ24@201174,4FFS3@85021,COG0543@1,COG0543@2	NA|NA|NA	C	Dihydroorotate oxidase
MAG.T12.45_01167	1048339.KB913029_gene3976	0.0	1644.0	Frankiales	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	Bacteria	2GK5N@201174,4ERGS@85013,COG0458@1,COG0458@2	NA|NA|NA	F	Belongs to the CarB family
MAG.T12.45_01168	1996.JOFO01000043_gene6393	7.7e-23	114.8	Actinobacteria													Bacteria	2GN14@201174,COG2267@1,COG2267@2	NA|NA|NA	I	Alpha/beta hydrolase family
MAG.T12.45_01169	1155718.KB891896_gene2090	2.2e-157	562.0	Actinobacteria	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955,ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040	Bacteria	2GKFA@201174,COG0505@1,COG0505@2	NA|NA|NA	F	Belongs to the CarA family
MAG.T12.45_01170	443255.SCLAV_0714	2.4e-29	135.6	Actinobacteria													Bacteria	2GM9I@201174,COG0505@1,COG0505@2	NA|NA|NA	EF	Belongs to the CarA family
MAG.T12.45_01171	1146883.BLASA_2361	8.6e-179	633.3	Frankiales	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ0T@201174,4ERCY@85013,COG0044@1,COG0044@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MAG.T12.45_01172	1123320.KB889665_gene1431	3.1e-138	498.0	Actinobacteria	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15490	Bacteria	2GKNA@201174,COG0540@1,COG0540@2	NA|NA|NA	F	Belongs to the ATCase OTCase family
MAG.T12.45_01173	1123320.KB889665_gene1430	7.1e-63	246.9	Actinobacteria	pyrR	GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000,ko03000			iHN637.CLJU_RS05275	Bacteria	2GJNP@201174,COG2065@1,COG2065@2	NA|NA|NA	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MAG.T12.45_01174	1449353.JQMQ01000005_gene847	3.1e-40	171.0	Streptacidiphilus	bldD			ko:K07110,ko:K21572					ko00000,ko02000,ko03000	8.A.46.1,8.A.46.3			Bacteria	2GVFR@201174,2NEHZ@228398,COG1395@1,COG1395@2	NA|NA|NA	K	Helix-turn-helix
MAG.T12.45_01175	67352.JODS01000047_gene3531	1.8e-122	446.0	Actinobacteria	meaA		5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2N3@201174,COG2185@1,COG2185@2	NA|NA|NA	I	Methylmalonyl-CoA mutase
MAG.T12.45_01176	1454010.JEOE01000017_gene1266	8e-74	283.9	Cellulomonadaceae				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN6S@201174,4F0I9@85016,COG0842@1,COG0842@2	NA|NA|NA	V	PFAM ABC-2 type transporter
MAG.T12.45_01177	1211815.CBYP010000045_gene812	2.6e-99	368.6	Frankiales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJBF@201174,4EUKR@85013,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T12.45_01178	477641.MODMU_4528	2e-91	342.0	Frankiales	nucS			ko:K07503					ko00000,ko01000				Bacteria	2GIYB@201174,4ES1R@85013,COG1637@1,COG1637@2	NA|NA|NA	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MAG.T12.45_01179	1169161.KB897725_gene1738	4.7e-93	348.2	Actinobacteria	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256			R11702		ko00000,ko01000,ko01003		GT4		Bacteria	2GKQ8@201174,COG0438@1,COG0438@2	NA|NA|NA	M	PFAM Glycosyl transferase, group 1
MAG.T12.45_01180	566461.SSFG_05851	5.2e-82	311.2	Actinobacteria	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2GM7B@201174,COG1560@1,COG1560@2	NA|NA|NA	M	Lipid A biosynthesis
MAG.T12.45_01181	1089455.MOPEL_021_00590	2e-43	182.6	Dermatophilaceae	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070		R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000				Bacteria	2GYKW@201174,4F6UB@85018,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T12.45_01183	1121020.JIAG01000013_gene1260	6.7e-36	157.1	Micrococcaceae													Bacteria	1W7ZN@1268,2I2F0@201174,COG0515@1,COG0515@2	NA|NA|NA	KLT	Domain of unknown function (DUF4032)
MAG.T12.45_01184	1123073.KB899241_gene2314	1.4e-28	133.7	Xanthomonadales			3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31		Bacteria	1RAB4@1224,1S2JK@1236,1X7DU@135614,COG0366@1,COG0366@2,COG2819@1,COG2819@2	NA|NA|NA	G	Putative esterase
MAG.T12.45_01185	66377.JOBH01000005_gene2852	5.1e-96	357.8	Actinobacteria	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218					ko00000,ko01000,ko03009				Bacteria	2GJMR@201174,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T12.45_01186	446468.Ndas_4314	2.8e-159	568.5	Streptosporangiales	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJF2@201174,4EFX4@85012,COG0215@1,COG0215@2	NA|NA|NA	J	DALR_2
MAG.T12.45_01187	390989.JOEG01000009_gene1007	6.2e-56	223.8	Micromonosporales	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.1.1.228,2.7.7.60,4.6.1.12	ko:K00554,ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05633,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016			iNJ661.Rv3581c	Bacteria	2II8H@201174,4DDC4@85008,COG0245@1,COG0245@2	NA|NA|NA	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MAG.T12.45_01188	862751.SACTE_3674	9.5e-47	193.7	Actinobacteria	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12	ko:K00991,ko:K12506,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633,R05637	RC00002,RC00089,RC01440	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNHP@201174,COG1211@1,COG1211@2	NA|NA|NA	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MAG.T12.45_01189	351607.Acel_0079	1.2e-69	270.4	Bacteria	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944											Bacteria	COG4956@1,COG4956@2	NA|NA|NA	S	nuclease activity
MAG.T12.45_01190	1206101.AZXC01000007_gene2361	5.8e-72	276.9	Actinobacteria	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496		ko:K07736					ko00000,ko03000				Bacteria	2GKSU@201174,COG1329@1,COG1329@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_01191	452652.KSE_34500	4.2e-09	68.2	Kitasatospora													Bacteria	2E56G@1,2GK9W@201174,2M3DR@2063,32ZZ6@2	NA|NA|NA		
MAG.T12.45_01192	1122247.C731_0827	6.8e-95	353.6	Mycobacteriaceae													Bacteria	234EX@1762,2GKFS@201174,COG0745@1,COG0745@2	NA|NA|NA	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MAG.T12.45_01193	43759.JNWK01000017_gene7629	4.4e-81	308.5	Actinobacteria	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07636,ko:K07768,ko:K11383	ko02020,map02020	M00434,M00443,M00505			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2GJY7@201174,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_01194	1463855.JOHV01000011_gene4088	6.5e-61	240.7	Actinobacteria	phoU			ko:K02039					ko00000				Bacteria	2GKAD@201174,COG0704@1,COG0704@2	NA|NA|NA	P	Plays a role in the regulation of phosphate uptake
MAG.T12.45_01195	644283.Micau_5680	1.7e-139	502.7	Micromonosporales	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521					ko00000,ko01000				Bacteria	2GJ57@201174,4D8PR@85008,COG0438@1,COG0438@2	NA|NA|NA	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway
MAG.T12.45_01196	1169161.KB897713_gene6602	1e-43	183.3	Actinobacteria													Bacteria	2AZ39@1,2GMCY@201174,31R9K@2	NA|NA|NA	S	Putative bacterial sensory transduction regulator
MAG.T12.45_01198	998088.B565_2809	7.1e-36	158.3	Aeromonadales													Bacteria	1NEEG@1224,1RZMD@1236,1Y4XF@135624,COG4938@1,COG4938@2	NA|NA|NA	D	AAA ATPase domain
MAG.T12.45_01199	685727.REQ_34670	1.1e-186	659.8	Nocardiaceae	cdr			ko:K04085	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	2H7WY@201174,4FX6B@85025,COG0446@1,COG0446@2,COG0607@1,COG0607@2	NA|NA|NA	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
MAG.T12.45_01200	1122182.KB903816_gene1626	4.5e-26	123.2	Micromonosporales	cspA			ko:K03704					ko00000,ko03000				Bacteria	2GQRU@201174,4DEWR@85008,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
MAG.T12.45_01202	1341646.CBMO010000035_gene4653	3e-139	502.3	Mycobacteriaceae	sulP	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	236K7@1762,2GJCB@201174,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate transporter
MAG.T12.45_01203	717773.Thicy_0930	2.5e-63	249.2	Bacteria													Bacteria	COG1887@1,COG1887@2	NA|NA|NA	M	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAG.T12.45_01205	862751.SACTE_5342	2.2e-227	795.0	Actinobacteria	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.14.13.83,1.7.7.1,1.8.7.1	ko:K00366,ko:K00392,ko:K02229	ko00860,ko00910,ko00920,ko01100,ko01120,map00860,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600,R05217	RC00065,RC00176,RC01979	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJRN@201174,COG0155@1,COG0155@2	NA|NA|NA	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAG.T12.45_01206	1121946.AUAX01000030_gene1321	1.2e-10	72.0	Micromonosporales													Bacteria	2GQKE@201174,4DGEE@85008,COG3677@1,COG3677@2	NA|NA|NA	L	Transposase
MAG.T12.45_01207	2074.JNYD01000008_gene1248	8.8e-13	79.0	Actinobacteria													Bacteria	2IPQX@201174,COG3328@1,COG3328@2	NA|NA|NA	L	Transposase, Mutator family
MAG.T12.45_01208	557599.MKAN_02490	2.7e-213	748.4	Mycobacteriaceae				ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	236NP@1762,2IBD6@201174,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_01209	525368.HMPREF0591_1854	8.8e-100	370.2	Mycobacteriaceae													Bacteria	2374G@1762,2I9ZX@201174,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_01210	1184609.KILIM_005_00340	8.4e-153	547.0	Actinobacteria													Bacteria	2GM8F@201174,COG3328@1,COG3328@2	NA|NA|NA	L	Transposase
MAG.T12.45_01213	1323361.JPOC01000066_gene82	2e-79	303.1	Nocardiaceae				ko:K06889					ko00000				Bacteria	2IA0F@201174,4FUH3@85025,COG1073@1,COG1073@2	NA|NA|NA	S	BAAT / Acyl-CoA thioester hydrolase C terminal
MAG.T12.45_01214	543632.JOJL01000024_gene1982	2.2e-36	159.1	Micromonosporales													Bacteria	2IIA5@201174,4DEYA@85008,COG0640@1,COG0640@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T12.45_01216	1120960.ATXG01000002_gene2757	3e-111	408.7	Microbacteriaceae				ko:K06994					ko00000				Bacteria	2GJ5A@201174,4FK7G@85023,COG2409@1,COG2409@2	NA|NA|NA	D	MMPL family
MAG.T12.45_01217	67352.JODS01000006_gene6539	4.4e-31	140.2	Actinobacteria	sucD		6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK00@201174,COG0074@1,COG0074@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAG.T12.45_01218	1120950.KB892760_gene5721	1.7e-22	114.0	Propionibacteriales				ko:K07148					ko00000				Bacteria	2GKA8@201174,4DQSU@85009,COG2311@1,COG2311@2	NA|NA|NA	S	Membrane
MAG.T12.45_01219	43354.JOIJ01000010_gene2460	3.3e-64	251.5	Pseudonocardiales	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2,2.1.2.3,3.5.4.10	ko:K00602,ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04325,R04326,R04560	RC00026,RC00197,RC00263,RC00456,RC01128	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2H8QB@201174,4DY8H@85010,COG0299@1,COG0299@2	NA|NA|NA	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MAG.T12.45_01220	44060.JODL01000002_gene2206	1.2e-211	742.7	Actinobacteria	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147			iHN637.CLJU_RS04230,iJN678.purH	Bacteria	2GJWU@201174,COG0138@1,COG0138@2	NA|NA|NA	F	Bifunctional purine biosynthesis protein PurH
MAG.T12.45_01221	633149.Bresu_2234	7.2e-65	254.2	Caulobacterales	MA20_05625												Bacteria	1MU9Y@1224,2KF3K@204458,2TUH0@28211,COG0647@1,COG0647@2	NA|NA|NA	G	Hydrolase
MAG.T12.45_01222	269800.Tfu_2571	2.9e-115	421.8	Streptosporangiales	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZS@201174,4EH3U@85012,COG0190@1,COG0190@2	NA|NA|NA	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MAG.T12.45_01223	1120950.KB892760_gene5727	6.2e-10	70.5	Bacteria													Bacteria	2DRQP@1,33CNM@2	NA|NA|NA	S	Protein of unknown function (DUF3017)
MAG.T12.45_01224	1380393.JHVP01000002_gene1784	1.5e-140	505.8	Frankiales	mdh		1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN5S@201174,4ESBM@85013,COG0039@1,COG0039@2	NA|NA|NA	C	Catalyzes the reversible oxidation of malate to oxaloacetate
MAG.T12.45_01225	998088.B565_1091	1.5e-24	119.4	Proteobacteria													Bacteria	1NKFS@1224,COG3832@1,COG3832@2	NA|NA|NA	S	Activator of Hsp90 ATPase homolog 1-like protein
MAG.T12.45_01226	1003195.SCAT_2410	1.2e-20	106.7	Actinobacteria	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975					ko00000,ko01000,ko03016				Bacteria	2GNDN@201174,COG1514@1,COG1514@2	NA|NA|NA	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MAG.T12.45_01227	525368.HMPREF0591_1878	5.5e-220	770.4	Mycobacteriaceae													Bacteria	2377M@1762,2GM4J@201174,COG4584@1,COG4584@2	NA|NA|NA	L	Transposase
MAG.T12.45_01228	710696.Intca_2901	1.5e-38	165.2	Intrasporangiaceae	higB			ko:K07334					ko00000,ko02048				Bacteria	2HVCI@201174,4FJJ2@85021,COG3549@1,COG3549@2	NA|NA|NA	S	RelE-like toxin of type II toxin-antitoxin system HigB
MAG.T12.45_01229	367299.JOEE01000003_gene2916	5.4e-41	173.3	Intrasporangiaceae	higA			ko:K21498					ko00000,ko02048				Bacteria	2IR2S@201174,4FHGX@85021,COG3093@1,COG3093@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T12.45_01230	996637.SGM_1410	5.5e-105	389.8	Actinobacteria													Bacteria	2GQIV@201174,COG5635@1,COG5635@2	NA|NA|NA	T	Nacht domain
MAG.T12.45_01231	1048339.KB913029_gene4661	1.7e-228	798.5	Frankiales	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	2GMN1@201174,4ES5H@85013,COG0174@1,COG0174@2	NA|NA|NA	E	TIGRFAM glutamine synthetase, type I
MAG.T12.45_01232	1389489.O159_15820	2.4e-10	71.6	Microbacteriaceae													Bacteria	2IQMG@201174,4FPA3@85023,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T12.45_01233	1449069.JMLO01000017_gene3295	1.4e-28	133.7	Nocardiaceae	VP1530			ko:K07164					ko00000				Bacteria	2GN5K@201174,4FWY1@85025,COG1579@1,COG1579@2,COG5473@1,COG5473@2	NA|NA|NA	J	Zn-ribbon protein possibly nucleic acid-binding
MAG.T12.45_01234	1122138.AQUZ01000081_gene4871	2.6e-44	186.0	Propionibacteriales	mutT		3.6.1.55	ko:K03574,ko:K08296					ko00000,ko01000,ko03400				Bacteria	2I2N2@201174,4DWX8@85009,COG1051@1,COG1051@2,COG2062@1,COG2062@2	NA|NA|NA	FT	Phosphoglycerate mutase family
MAG.T12.45_01235	1304865.JAGF01000001_gene2382	1e-114	420.6	Actinobacteria													Bacteria	2GJZH@201174,COG5607@1,COG5607@2	NA|NA|NA	S	CHAD domain containing protein
MAG.T12.45_01236	1894.JOER01000041_gene1494	4.3e-284	983.8	Actinobacteria	ppk		2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GJ0B@201174,COG0855@1,COG0855@2	NA|NA|NA	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MAG.T12.45_01237	35754.JNYJ01000038_gene4955	2.8e-81	308.9	Micromonosporales	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189,2.7.4.1	ko:K00937,ko:K15520	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GM35@201174,4D8MC@85008,COG0454@1,COG0456@2	NA|NA|NA	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol
MAG.T12.45_01238	28444.JODQ01000002_gene4547	2.7e-89	335.1	Streptosporangiales													Bacteria	2GJGU@201174,4EI8P@85012,COG0745@1,COG0745@2	NA|NA|NA	KT	Transcriptional regulatory protein, C terminal
MAG.T12.45_01239	471852.Tcur_0600	3.6e-37	161.4	Streptosporangiales	thiX		1.8.1.8	ko:K02199,ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko01000,ko03110				Bacteria	2IKMI@201174,4EK0E@85012,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin
MAG.T12.45_01240	436229.JOEH01000023_gene761	2.4e-32	145.2	Streptacidiphilus													Bacteria	2AN8T@1,2I81P@201174,2NNJW@228398,327DN@2	NA|NA|NA	S	Domain of unknown function (DUF4395)
MAG.T12.45_01241	561175.KB894093_gene2870	9.2e-18	98.6	Streptosporangiales				ko:K14340					ko00000,ko01000,ko01003				Bacteria	2GN7C@201174,4EPB5@85012,COG5305@1,COG5305@2	NA|NA|NA	S	Dolichyl-phosphate-mannose-protein mannosyltransferase
MAG.T12.45_01242	269800.Tfu_2924	1.4e-33	149.1	Streptosporangiales													Bacteria	2IHT6@201174,4EJN0@85012,COG2044@1,COG2044@2	NA|NA|NA	S	DsrE/DsrF-like family
MAG.T12.45_01244	1120950.KB892795_gene2292	1.3e-40	172.9	Propionibacteriales		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GKGF@201174,4DQW9@85009,COG4044@1,COG4044@2	NA|NA|NA	S	May play a role in the intracellular transport of hydrophobic ligands
MAG.T12.45_01245	390989.JOEG01000027_gene2201	2.7e-31	141.7	Micromonosporales				ko:K03711					ko00000,ko03000				Bacteria	2IFHB@201174,4DEKA@85008,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T12.45_01246	1120950.KB892795_gene2294	3.8e-79	302.0	Propionibacteriales			1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	2I4ER@201174,4DX1V@85009,COG0404@1,COG0404@2	NA|NA|NA	E	Glycine cleavage T-protein C-terminal barrel domain
MAG.T12.45_01247	1172188.KB911820_gene2608	1.1e-61	243.4	Intrasporangiaceae													Bacteria	2H8JM@201174,4FG88@85021,COG0491@1,COG0491@2	NA|NA|NA	S	Metallo-beta-lactamase superfamily
MAG.T12.45_01248	452652.KSE_43730	9.9e-40	169.9	Kitasatospora	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K07560					ko00000,ko01000,ko03016				Bacteria	2IKVR@201174,2M30U@2063,COG1490@1,COG1490@2	NA|NA|NA	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MAG.T12.45_01249	1128421.JAGA01000002_gene21	2.8e-10	73.2	unclassified Bacteria													Bacteria	2NRMR@2323,COG0457@1,COG0457@2	NA|NA|NA	O	heat shock protein binding
MAG.T12.45_01251	351607.Acel_0628	6.2e-206	723.8	Frankiales	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iAF987.Gmet_1434	Bacteria	2GKQ3@201174,4ERR2@85013,COG0018@1,COG0018@2	NA|NA|NA	J	Arginyl-tRNA synthetase
MAG.T12.45_01252	2074.JNYD01000014_gene7070	3.1e-16	92.8	Pseudonocardiales				ko:K07058					ko00000				Bacteria	2GM6P@201174,4E0J5@85010,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T12.45_01253	1211815.CBYP010000042_gene2347	9.9e-160	570.1	Frankiales	lysA		4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKAI@201174,4ERM5@85013,COG0019@1,COG0019@2	NA|NA|NA	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MAG.T12.45_01254	935866.JAER01000014_gene1722	3.4e-82	312.0	Propionibacteriales	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1294,iSB619.SA_RS06610	Bacteria	2GIX9@201174,4DPCG@85009,COG0460@1,COG0460@2	NA|NA|NA	E	Homoserine dehydrogenase
MAG.T12.45_01255	1206731.BAGB01000164_gene4329	4.2e-61	241.5	Nocardiaceae													Bacteria	2GM3I@201174,4G8PP@85025,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T12.45_01256	1032480.MLP_32170	8.3e-07	60.5	Bacteria				ko:K03668,ko:K09914					ko00000				Bacteria	COG3187@1,COG3187@2	NA|NA|NA	O	response to heat
MAG.T12.45_01257	105420.BBPO01000043_gene3657	1.5e-74	286.2	Streptacidiphilus				ko:K07052					ko00000				Bacteria	2GK11@201174,2NHZA@228398,COG1266@1,COG1266@2	NA|NA|NA	S	CAAX protease self-immunity
MAG.T12.45_01258	105425.BBPL01000021_gene769	1e-137	496.5	Streptacidiphilus	pdhA		1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GK3W@201174,2NFED@228398,COG1071@1,COG1071@2	NA|NA|NA	C	Dehydrogenase E1 component
MAG.T12.45_01259	469371.Tbis_3331	6.3e-126	457.2	Pseudonocardiales	pdhB	GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS05355,iYO844.BSU14590	Bacteria	2GKFE@201174,4E0CR@85010,COG0022@1,COG0022@2	NA|NA|NA	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit
MAG.T12.45_01260	1211815.CBYP010000051_gene667	2.2e-97	362.8	Frankiales	pdhC		2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GM0D@201174,4ERC0@85013,COG0508@1,COG0508@2	NA|NA|NA	C	of components of various dehydrogenase complexes
MAG.T12.45_01261	979556.MTES_2299	1.2e-44	186.0	Microbacteriaceae	sbcC	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006260,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576		ko:K03546					ko00000,ko03400				Bacteria	2GKYR@201174,4FKUJ@85023,COG0419@1,COG0419@2	NA|NA|NA	L	Putative exonuclease SbcCD, C subunit
MAG.T12.45_01262	313589.JNB_13298	1.2e-16	92.4	Intrasporangiaceae			3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000		GH32		Bacteria	2H3S0@201174,4FEDK@85021,COG1621@1,COG1621@2	NA|NA|NA	G	Glycosyl hydrolase family 32
MAG.T12.45_01263	1123320.KB889748_gene4519	7.9e-156	557.0	Actinobacteria	thrC1		4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNM0@201174,COG0498@1,COG0498@2	NA|NA|NA	E	Threonine synthase
MAG.T12.45_01264	479432.Sros_8912	8.9e-25	119.4	Streptosporangiales			2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122		R07459,R07461	RC00043	ko00000,ko00001,ko01000				Bacteria	2IQBT@201174,4EKIY@85012,COG1977@1,COG1977@2	NA|NA|NA	H	ThiS family
MAG.T12.45_01265	479433.Caci_7815	8.4e-181	639.8	Actinobacteria	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11,3.1.2.6	ko:K01069,ko:K21029,ko:K21147	ko00620,ko04122,map00620,map04122		R01736,R07459,R07461	RC00004,RC00043,RC00137	ko00000,ko00001,ko01000				Bacteria	2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2	NA|NA|NA	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are
MAG.T12.45_01266	1120936.KB907209_gene1439	4.3e-78	298.1	Streptosporangiales	ssuC			ko:K02050		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17			Bacteria	2GIWG@201174,4EI0V@85012,COG0600@1,COG0600@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_01267	512565.AMIS_73420	6e-51	207.2	Micromonosporales	ssuB			ko:K02049		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17			Bacteria	2GN33@201174,4DBHB@85008,COG1116@1,COG1116@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T12.45_01268	93220.LV28_08510	2e-210	738.8	Burkholderiaceae	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018				ko00000,ko00001,ko01000,ko03400				Bacteria	1K353@119060,1MVGG@1224,2VH8W@28216,COG0514@1,COG0514@2	NA|NA|NA	L	ATP-dependent DNA helicase RecQ
MAG.T12.45_01269	1146883.BLASA_3489	1.2e-95	356.7	Actinobacteria													Bacteria	2H3MV@201174,COG0210@1,COG0210@2,COG1112@1,COG1112@2	NA|NA|NA	L	Type III restriction enzyme res subunit
MAG.T12.45_01271	397278.JOJN01000002_gene104	2.6e-122	445.3	Propionibacteriales	groL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	2GKC9@201174,4DNCJ@85009,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MAG.T12.45_01272	1114959.SZMC14600_05067	3e-34	151.0	Pseudonocardiales	whiB3	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0009273,GO:0009405,GO:0009987,GO:0010565,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0019216,GO:0019217,GO:0019222,GO:0019725,GO:0030312,GO:0031323,GO:0042546,GO:0042592,GO:0043254,GO:0044085,GO:0044087,GO:0044419,GO:0044464,GO:0045454,GO:0048037,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0051704,GO:0055114,GO:0062012,GO:0065007,GO:0065008,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090034,GO:0097159,GO:1901363,GO:1902882		ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQS5@201174,32S23@2,4E4SU@85010	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T12.45_01273	675635.Psed_5357	5e-58	231.9	Pseudonocardiales	litR			ko:K22491					ko00000,ko03000				Bacteria	2I8T8@201174,4DZZC@85010,COG0789@1,COG0789@2	NA|NA|NA	K	MerR HTH family regulatory protein
MAG.T12.45_01274	710421.Mycch_1110	7.9e-14	84.7	Mycobacteriaceae													Bacteria	233QX@1762,2F0NR@1,2GUJF@201174,33TR6@2	NA|NA|NA		
MAG.T12.45_01275	1306174.JODP01000006_gene3624	5.1e-65	254.2	Actinobacteria	bldM												Bacteria	2GN46@201174,COG2197@1,COG2197@2	NA|NA|NA	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MAG.T12.45_01276	1095767.CAHD01000133_gene1273	1.5e-227	795.4	Cellulomonadaceae	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GITZ@201174,4F0EC@85016,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MAG.T12.45_01277	1120950.KB892783_gene342	2.5e-147	528.5	Propionibacteriales	guaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GKVS@201174,4DN1G@85009,COG0516@1,COG0516@2	NA|NA|NA	F	IMP dehydrogenase / GMP reductase domain
MAG.T12.45_01278	105420.BBPO01000010_gene2316	2e-146	526.2	Streptacidiphilus	glpD		1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000				Bacteria	2GJKN@201174,2NHAR@228398,COG0578@1,COG0578@2	NA|NA|NA	C	C-terminal domain of alpha-glycerophosphate oxidase
MAG.T12.45_01279	1184609.KILIM_065_00100	2e-145	522.7	Dermatophilaceae	gabD2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10	ko:K00135,ko:K22445	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ95@201174,4F6MX@85018,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T12.45_01280	345341.KUTG_05928	1.5e-197	696.0	Pseudonocardiales	choD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120		R01459	RC00146	ko00000,ko00001,ko01000				Bacteria	2GJ3J@201174,4DYHW@85010,COG2303@1,COG2303@2	NA|NA|NA	E	Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence
MAG.T12.45_01281	680646.RMDY18_05410	7e-39	168.3	Actinobacteria													Bacteria	2BVI1@1,2H25T@201174,32QWD@2	NA|NA|NA		
MAG.T12.45_01282	512565.AMIS_71630	2.5e-19	101.3	Micromonosporales	trxA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko03110				Bacteria	2GJ7B@201174,4D937@85008,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin
MAG.T12.45_01283	1123320.KB889709_gene8400	0.0	1079.3	Actinobacteria	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	2GJ5C@201174,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAG.T12.45_01284	471852.Tcur_3583	3.8e-210	738.0	Streptosporangiales	glgE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100		R09994		ko00000,ko00001,ko01000		GH13		Bacteria	2GJKR@201174,4EG8Q@85012,COG0366@1,COG0366@2	NA|NA|NA	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB
MAG.T12.45_01285	1123320.KB889709_gene8414	8.8e-266	922.9	Actinobacteria	glgX		3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261		ko00000,ko00001,ko00002,ko01000		CBM48,GH13		Bacteria	2GJ00@201174,COG1523@1,COG1523@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 13 family
MAG.T12.45_01286	269800.Tfu_0590	5.4e-75	287.7	Streptosporangiales	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJW5@201174,4EH13@85012,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase/isomerase
MAG.T12.45_01287	1171373.PACID_16570	2.2e-49	202.2	Propionibacteriales	pgsA	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	2GM3F@201174,4DQ8M@85009,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T12.45_01288	58123.JOFJ01000007_gene696	1e-281	976.1	Streptosporangiales	mpg		1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8	ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00361,M00362	R00885,R00959,R01057,R01818,R02060,R08639	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_3178	Bacteria	2GKTE@201174,4EFSZ@85012,COG1109@1,COG1109@2,COG1208@1,COG1208@2	NA|NA|NA	GJM	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
MAG.T12.45_01289	479433.Caci_3123	1.2e-27	130.6	Actinobacteria		GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2GMS5@201174,COG3879@1,COG3879@2	NA|NA|NA	S	protein conserved in bacteria
MAG.T12.45_01290	1306174.JODP01000002_gene5961	1.7e-35	155.2	Actinobacteria	sbp												Bacteria	2IKJW@201174,COG3856@1,COG3856@2	NA|NA|NA	S	conserved protein (small basic protein)
MAG.T12.45_01291	1385518.N798_07750	1.2e-37	163.7	Intrasporangiaceae		GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2GJ3C@201174,4FEXI@85021,COG3879@1,COG3879@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF881)
MAG.T12.45_01292	222534.KB893671_gene3398	2.2e-37	161.8	Frankiales	gcvH			ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002			iNJ661.Rv1826	Bacteria	2IKN2@201174,4ESYX@85013,COG0509@1,COG0509@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
MAG.T12.45_01293	570268.ANBB01000003_gene540	1.8e-36	159.1	Streptosporangiales													Bacteria	2GK99@201174,4EJ30@85012,COG1716@1,COG1716@2	NA|NA|NA	T	Inner membrane component of T3SS, cytoplasmic domain
MAG.T12.45_01294	1120950.KB892707_gene5034	8.9e-64	250.4	Propionibacteriales	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464											Bacteria	2HBV6@201174,4DQDI@85009,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T12.45_01298	590998.Celf_3037	4.1e-75	288.5	Actinobacteria													Bacteria	2IG08@201174,COG1216@1,COG1216@2	NA|NA|NA	M	Glycosyltransferase, group 2 family protein
MAG.T12.45_01299	1449069.JMLO01000017_gene3331	3.8e-84	319.3	Actinobacteria													Bacteria	2C825@1,2IGR2@201174,32RK8@2	NA|NA|NA		
MAG.T12.45_01301	1068980.ARVW01000001_gene6598	8.8e-54	217.2	Actinobacteria													Bacteria	2GNFE@201174,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T12.45_01302	590998.Celf_3031	9e-45	186.4	Actinobacteria	tagD		2.7.7.39	ko:K00980	ko00564,map00564		R00856	RC00002	ko00000,ko00001,ko01000				Bacteria	2GKU1@201174,COG0615@1,COG0615@2	NA|NA|NA	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MAG.T12.45_01303	979556.MTES_0953	1.3e-53	217.2	Bacteria	wcoF												Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T12.45_01304	1120936.KB907208_gene780	2.6e-75	289.7	Streptosporangiales	rfbP												Bacteria	2GK0M@201174,4EGMN@85012,COG2148@1,COG2148@2	NA|NA|NA	M	Bacterial sugar transferase
MAG.T12.45_01305	1463901.JOIY01000024_gene6226	9.1e-207	726.5	Actinobacteria	serA		1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJGA@201174,COG0111@1,COG0111@2	NA|NA|NA	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAG.T12.45_01306	1273125.Rrhod_2717	5.7e-37	161.8	Nocardiaceae	pflA			ko:K15539					ko00000				Bacteria	2GNIS@201174,4FVJA@85025,COG2976@1,COG2976@2	NA|NA|NA	S	Protein of unknown function (DUF4012)
MAG.T12.45_01308	47839.CCAU010000011_gene5295	1.7e-20	106.3	Mycobacteriaceae													Bacteria	2391H@1762,2IMN5@201174,COG1309@1,COG1309@2	NA|NA|NA	K	WHG domain
MAG.T12.45_01309	1108045.GORHZ_053_00570	4.5e-64	251.5	Gordoniaceae	vdlC												Bacteria	2IIVW@201174,4GE8H@85026,COG0300@1,COG0300@2	NA|NA|NA	S	NAD(P)H-binding
MAG.T12.45_01311	1254432.SCE1572_28415	1.6e-33	149.4	Proteobacteria	betI9												Bacteria	1N6TK@1224,COG1309@1,COG1309@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01312	318424.EU78_15100	1.7e-24	119.4	Bacteria			2.3.1.82	ko:K18815					br01600,ko00000,ko01000,ko01504				Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T12.45_01313	1094980.Mpsy_0339	3e-14	84.7	Methanomicrobia				ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Archaea	2NA44@224756,2Y1ZP@28890,COG1226@1,arCOG01958@2157	NA|NA|NA	P	Ion channel
MAG.T12.45_01317	1121017.AUFG01000027_gene526	8.1e-24	119.0	Actinobacteria													Bacteria	2GPWU@201174,COG0323@1,COG0323@2	NA|NA|NA	L	PFAM Relaxase mobilization nuclease family protein
MAG.T12.45_01319	1121946.AUAX01000019_gene7777	9.7e-63	246.9	Actinobacteria													Bacteria	2ISWE@201174,COG3340@1,COG3340@2	NA|NA|NA	E	Peptidase family S51
MAG.T12.45_01320	351607.Acel_2052	5.8e-65	255.0	Actinobacteria			3.4.13.21,3.4.15.6	ko:K05995,ko:K13282			R09722	RC00064,RC00141	ko00000,ko01000,ko01002				Bacteria	2I98G@201174,COG0215@1,COG0215@2,COG4242@1,COG4242@2	NA|NA|NA	J	Belongs to the peptidase S51 family
MAG.T12.45_01321	1463825.JNXC01000005_gene2483	2.9e-49	201.8	Pseudonocardiales	bioY			ko:K02014,ko:K03523	ko02010,map02010	M00581,M00582			ko00000,ko00001,ko00002,ko02000	1.B.14,2.A.88.1,2.A.88.2			Bacteria	2GJ53@201174,4E2ZE@85010,COG1268@1,COG1268@2	NA|NA|NA	S	BioY family
MAG.T12.45_01322	1032480.MLP_29440	1e-207	729.6	Propionibacteriales	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2GJJH@201174,4DNB4@85009,COG0064@1,COG0064@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T12.45_01323	235985.BBPN01000056_gene7833	2.4e-217	761.5	Streptacidiphilus	gatA		6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2GJK5@201174,2NHY5@228398,COG0154@1,COG0154@2	NA|NA|NA	J	Amidase
MAG.T12.45_01324	1122182.KB903834_gene5703	3.4e-25	120.9	Micromonosporales	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2IQJN@201174,4DEPX@85008,COG0721@1,COG0721@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T12.45_01325	266940.Krad_1315	2.3e-227	795.4	Actinobacteria	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	2GJUY@201174,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MAG.T12.45_01326	981369.JQMJ01000004_gene5729	9.6e-61	240.7	Streptacidiphilus			2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMPS@201174,2NF4D@228398,COG0620@1,COG0620@2	NA|NA|NA	E	Cobalamin-independent synthase, Catalytic domain
MAG.T12.45_01327	1122919.KB905604_gene4558	9.7e-82	310.5	Paenibacillaceae	ygjR	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497		ko:K22230	ko00562,ko01120,map00562,map01120		R09954	RC00182	ko00000,ko00001,ko01000				Bacteria	1TQSS@1239,26SCY@186822,4HCIG@91061,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase
MAG.T12.45_01328	1172188.KB911821_gene1287	1.1e-15	89.4	Intrasporangiaceae													Bacteria	2E45J@1,2GR89@201174,32Z1K@2,4FHGH@85021	NA|NA|NA	S	Branched-chain amino acid transport protein (AzlD)
MAG.T12.45_01329	1123251.ATWM01000001_gene699	1.3e-43	183.3	Intrasporangiaceae													Bacteria	2GN6R@201174,4FFT4@85021,COG1296@1,COG1296@2	NA|NA|NA	E	branched-chain amino acid
MAG.T12.45_01330	452652.KSE_51040	2.9e-132	478.4	Kitasatospora	mnmA		2.8.1.13	ko:K00566	ko04122,map04122		R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016				Bacteria	2GIUQ@201174,2M13X@2063,COG0482@1,COG0482@2	NA|NA|NA	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MAG.T12.45_01331	1348663.KCH_51370	2e-121	442.6	Kitasatospora	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GKUT@201174,2M12X@2063,COG1104@1,COG1104@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T12.45_01332	469371.Tbis_2845	1.8e-59	235.3	Pseudonocardiales	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03522					ko00000,ko04147				Bacteria	2GJWH@201174,4DY2C@85010,COG2025@1,COG2025@2	NA|NA|NA	C	Electron transfer flavoprotein alpha subunit
MAG.T12.45_01333	931627.MycrhDRAFT_4343	1.7e-250	872.1	Mycobacteriaceae	rne	GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394			ko00000,ko00001,ko00002,ko01000,ko03009,ko03019				Bacteria	2342K@1762,2GMM5@201174,COG1530@1,COG1530@2	NA|NA|NA	J	ribonuclease, Rne Rng family
MAG.T12.45_01334	1048339.KB913029_gene4852	1.3e-32	145.6	Frankiales	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02888	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2	NA|NA|NA	J	This protein binds to 23S rRNA in the presence of protein L20
MAG.T12.45_01335	471856.Jden_1651	6.7e-35	152.9	Actinobacteria	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904		ko:K02899	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQDI@201174,COG0211@1,COG0211@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL27 family
MAG.T12.45_01336	1123322.KB904724_gene1934	3.6e-179	634.8	Actinobacteria	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904		ko:K03979					ko00000,ko01000,ko03009				Bacteria	2GISB@201174,COG0536@1,COG0536@2	NA|NA|NA	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MAG.T12.45_01337	105425.BBPL01000002_gene6561	4.3e-124	451.4	Streptacidiphilus	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM8U@201174,2NG7R@228398,COG0263@1,COG0263@2	NA|NA|NA	E	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
MAG.T12.45_01338	500153.JOEK01000011_gene1945	1.3e-155	556.2	Actinobacteria	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130	Bacteria	2GISA@201174,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAG.T12.45_01340	1123024.AUII01000008_gene1827	3.9e-75	287.7	Pseudonocardiales	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2GMFZ@201174,4E0CB@85010,COG1057@1,COG1057@2	NA|NA|NA	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MAG.T12.45_01341	351607.Acel_0763	4.2e-44	185.7	Frankiales													Bacteria	2GNGN@201174,4EWPJ@85013,COG1316@1,COG1316@2	NA|NA|NA	K	LytR cell envelope-related transcriptional attenuator
MAG.T12.45_01342	1306174.JODP01000011_gene6740	3e-39	167.9	Actinobacteria	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2IKZ3@201174,COG0799@1,COG0799@2	NA|NA|NA	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MAG.T12.45_01343	253839.SSNG_02327	7.5e-57	227.3	Actinobacteria	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.73,3.1.3.85	ko:K02226,ko:K22306	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJYU@201174,COG0406@1,COG0406@2	NA|NA|NA	G	Belongs to the phosphoglycerate mutase family
MAG.T12.45_01345	590998.Celf_0702	8.8e-14	83.2	Actinobacteria													Bacteria	2EGDD@1,2GR3X@201174,33A58@2	NA|NA|NA	S	Phospholipase_D-nuclease N-terminal
MAG.T12.45_01349	1206732.BAGD01000097_gene4238	5.9e-45	188.0	Nocardiaceae													Bacteria	2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2	NA|NA|NA	E	Serine aminopeptidase, S33
MAG.T12.45_01350	930171.Asphe3_25570	1.5e-31	142.1	Micrococcaceae	fnlB		1.1.1.367	ko:K19068					ko00000,ko01000				Bacteria	1W83R@1268,2HJI9@201174,COG0451@1,COG0451@2,COG1898@1,COG1898@2	NA|NA|NA	GM	NAD dependent epimerase/dehydratase family
MAG.T12.45_01351	313589.JNB_18023	1.7e-138	499.2	Intrasporangiaceae	wecB		5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2GJWS@201174,4FG1P@85021,COG0381@1,COG0381@2	NA|NA|NA	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MAG.T12.45_01352	1032480.MLP_34460	3.6e-50	205.7	Propionibacteriales													Bacteria	28MCN@1,2GXXM@201174,2ZAQR@2,4DW15@85009	NA|NA|NA		
MAG.T12.45_01353	979556.MTES_2076	1e-73	283.9	Actinobacteria				ko:K02529					ko00000,ko03000				Bacteria	2GKFC@201174,COG1609@1,COG1609@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_01354	208444.JNYY01000016_gene805	2.4e-83	315.8	Pseudonocardiales													Bacteria	2GJBJ@201174,4E2I8@85010,COG1609@1,COG1609@2	NA|NA|NA	K	Bacterial regulatory proteins, lacI family
MAG.T12.45_01355	1032480.MLP_11610	5.3e-46	191.4	Actinobacteria													Bacteria	2IFGR@201174,COG2865@1,COG2865@2	NA|NA|NA	K	Putative DNA-binding domain
MAG.T12.45_01356	1219065.VPR01S_05_01810	1.1e-47	196.4	Vibrionales	lacA		2.3.1.79	ko:K00661					ko00000,ko01000				Bacteria	1RF1T@1224,1S4DA@1236,1XTJQ@135623,COG0110@1,COG0110@2	NA|NA|NA	S	COG0110 Acetyltransferase (isoleucine patch superfamily)
MAG.T12.45_01357	521674.Plim_2873	6.8e-71	275.0	Planctomycetes	mmoQ												Bacteria	2IZRQ@203682,COG1639@1,COG1639@2,COG2199@1,COG3706@2	NA|NA|NA	T	signal transduction protein
MAG.T12.45_01358	1136417.AZWE01000016_gene64	7.8e-73	281.2	Micromonosporales	yibF												Bacteria	2GKJ4@201174,4D8GP@85008,COG5438@1,COG5438@2	NA|NA|NA	S	YibE F family protein
MAG.T12.45_01359	446466.Cfla_1918	1e-59	236.9	Actinobacteria				ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	28HIR@1,2I860@201174,30UAY@2	NA|NA|NA	S	succinate dehydrogenase
MAG.T12.45_01360	446466.Cfla_1917	0.0	1117.4	Cellulomonadaceae	sdhA		1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ45@201174,4F0MT@85016,COG1053@1,COG1053@2	NA|NA|NA	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein
MAG.T12.45_01361	446466.Cfla_1916	4e-112	411.0	Actinobacteria	sdhB		1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJPS@201174,COG0479@1,COG0479@2	NA|NA|NA	C	succinate dehydrogenase
MAG.T12.45_01362	593907.Celgi_2505	1.1e-155	556.6	Actinobacteria	efeN			ko:K16301					ko00000,ko01000,ko02000	2.A.108.2.3			Bacteria	2GIUB@201174,COG2837@1,COG2837@2	NA|NA|NA	P	peroxidase
MAG.T12.45_01363	1151118.KB895783_gene3932	1e-46	193.0	Micrococcaceae	ycdO	GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511		ko:K07224					ko00000,ko02000	2.A.108.2.3			Bacteria	1W7Q8@1268,2GJPY@201174,COG2822@1,COG2822@2	NA|NA|NA	P	Imelysin
MAG.T12.45_01364	279303.Q6J817_9CAUD	5.3e-67	261.9	Siphoviridae													Viruses	4QG9U@10239,4QM4R@10699,4QSKC@28883,4R0A6@35237	NA|NA|NA		
MAG.T12.45_01366	1048339.KB913029_gene3874	4.7e-91	341.7	Frankiales	trmA	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215					ko00000,ko01000,ko03009,ko03016				Bacteria	2GIR3@201174,4ERZK@85013,COG2265@1,COG2265@2	NA|NA|NA	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MAG.T12.45_01367	2002.JOEQ01000014_gene5323	3.7e-204	718.0	Streptosporangiales													Bacteria	2GK5V@201174,4EH63@85012,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T12.45_01368	1123320.KB889719_gene7270	1.3e-73	282.3	Actinobacteria	phoH			ko:K07175					ko00000				Bacteria	2GK8U@201174,COG1875@1,COG1875@2	NA|NA|NA	T	ATPase related to phosphate starvation-inducible protein PhoH
MAG.T12.45_01369	1122239.AULS01000021_gene2490	3.4e-18	99.0	Actinobacteria				ko:K21471					ko00000,ko01000,ko01002,ko01011				Bacteria	2I5D4@201174,COG3206@1,COG3206@2	NA|NA|NA	M	NLP P60 protein
MAG.T12.45_01370	926550.CLDAP_40500	5.8e-62	244.6	Chloroflexi													Bacteria	2G6KN@200795,COG2220@1,COG2220@2	NA|NA|NA	S	Belongs to the UPF0173 family
MAG.T12.45_01371	1121946.AUAX01000020_gene3142	1.2e-166	593.6	Micromonosporales													Bacteria	2HH0Q@201174,4DAQP@85008,COG1524@1,COG1524@2	NA|NA|NA	S	Type I phosphodiesterase / nucleotide pyrophosphatase
MAG.T12.45_01372	981369.JQMJ01000004_gene6082	1.5e-255	888.6	Streptacidiphilus	fumB	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676,ko:K01677,ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778,iPC815.YPO3335	Bacteria	2GK6D@201174,2NHJN@228398,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Fumarase C-terminus
MAG.T12.45_01373	1122130.AUHN01000006_gene2126	8.5e-14	82.4	Actinobacteria	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02916	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQZW@201174,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
MAG.T12.45_01374	1184607.AUCHE_01_00170	1.7e-64	252.3	Dermatophilaceae	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Bacteria	2GJGT@201174,4F6SW@85018,COG0290@1,COG0290@2	NA|NA|NA	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MAG.T12.45_01375	452652.KSE_15250	1.2e-37	162.5	Kitasatospora													Bacteria	2AI3Y@1,2IHSQ@201174,2M2YX@2063,318HW@2	NA|NA|NA		
MAG.T12.45_01376	1123052.AUDF01000011_gene1510	5.5e-16	91.7	Microbacteriaceae	hisA	GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16,5.3.1.24	ko:K01814,ko:K01817,ko:K11755	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000				Bacteria	2I4YY@201174,4FKW9@85023,COG0106@1,COG0106@2	NA|NA|NA	E	SseB protein N-terminal domain
MAG.T12.45_01377	1120936.KB907209_gene1762	2.1e-77	296.6	Streptosporangiales	accD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNP7@201174,4EHG6@85012,COG0777@1,COG0777@2,COG0825@1,COG0825@2	NA|NA|NA	I	Carboxyl transferase domain
MAG.T12.45_01382	235985.BBPN01000007_gene3291	6.7e-187	660.6	Streptacidiphilus	ycfI			ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2GITR@201174,2NEN1@228398,COG1132@1,COG1132@2	NA|NA|NA	V	ABC transporter transmembrane region
MAG.T12.45_01383	2045.KR76_02335	1.5e-18	101.7	Propionibacteriales													Bacteria	2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T12.45_01384	222534.KB893694_gene64	1.2e-30	140.2	Frankiales													Bacteria	2I8Y7@201174,4EWZT@85013,COG2197@1,COG2197@2	NA|NA|NA	T	Response regulator receiver
MAG.T12.45_01385	66897.DJ64_20775	3.5e-116	424.9	Actinobacteria			3.2.1.23,3.2.1.97	ko:K01190,ko:K17624	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100		R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000		GH101		Bacteria	2I952@201174,COG3250@1,COG3250@2	NA|NA|NA	G	Protein of unknown function (DUF2804)
MAG.T12.45_01386	1348338.ADILRU_1018	4e-31	140.6	Microbacteriaceae				ko:K21600					ko00000,ko03000				Bacteria	2IQAC@201174,4FPHS@85023,COG1937@1,COG1937@2	NA|NA|NA	S	Metal-sensitive transcriptional repressor
MAG.T12.45_01387	110319.CF8_3936	8.8e-280	969.5	Propionibacteriales			3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	2GIRF@201174,4DN8M@85009,COG2217@1,COG2217@2	NA|NA|NA	P	Heavy-metal-associated domain
MAG.T12.45_01388	1366050.N234_19840	1.8e-38	165.6	Burkholderiaceae	ypeA			ko:K03826					ko00000,ko01000				Bacteria	1K7QV@119060,1RA6D@1224,2VSN2@28216,COG0454@1,COG0456@2	NA|NA|NA	K	PFAM GCN5-related N-acetyltransferase
MAG.T12.45_01389	591167.Sfla_5812	9.3e-37	160.2	Actinobacteria			3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000				Bacteria	2GRXY@201174,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T12.45_01391	1095767.CAHD01000239_gene1882	5.7e-59	234.6	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	28JAE@1,2IFSW@201174,2Z957@2	NA|NA|NA		
MAG.T12.45_01392	1122611.KB903948_gene6667	2.4e-78	298.5	Streptosporangiales	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Bacteria	2GJ4P@201174,4EGN4@85012,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MAG.T12.45_01393	1054860.KB913030_gene4976	0.0	1554.3	Actinobacteria	lhr	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K03724					ko00000,ko01000,ko03400				Bacteria	2GJG3@201174,COG1201@1,COG1201@2	NA|NA|NA	L	dead DEAH box helicase
MAG.T12.45_01394	1476876.JOJO01000017_gene1354	2.8e-23	114.4	Actinobacteria	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	2GR3F@201174,COG1396@1,COG1396@2	NA|NA|NA	K	transcriptional
MAG.T12.45_01395	1122239.AULS01000007_gene453	4.3e-25	121.3	Microbacteriaceae	cinA		3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	2IQ8T@201174,4FPN9@85023,COG1546@1,COG1546@2	NA|NA|NA	S	Competence-damaged protein
MAG.T12.45_01396	471852.Tcur_3305	9e-52	210.3	Streptosporangiales	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	2GK5D@201174,4EIN9@85012,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T12.45_01397	1120950.KB892756_gene6657	4.5e-155	554.7	Propionibacteriales	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441			R10652	RC00003,RC03217	ko00000,ko01000,ko03009				Bacteria	2GKRI@201174,4DNHY@85009,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
MAG.T12.45_01398	351607.Acel_1501	2.6e-252	878.6	Frankiales	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03466					ko00000,ko03036	3.A.12			Bacteria	2GK3T@201174,4ERQD@85013,COG1674@1,COG1674@2	NA|NA|NA	D	DNA translocase ftsK
MAG.T12.45_01399	1095767.CAHD01000224_gene2103	2.8e-238	831.2	Cellulomonadaceae	rnj	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K12574	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GIW7@201174,4F0MZ@85016,COG0595@1,COG0595@2	NA|NA|NA	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MAG.T12.45_01400	68570.DC74_5827	1.2e-107	396.4	Actinobacteria	dapA		4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ34@201174,COG0329@1,COG0329@2	NA|NA|NA	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAG.T12.45_01401	1193181.BN10_1320023	7.5e-57	227.3	Actinobacteria			6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	2IAKK@201174,COG1478@1,COG1478@2	NA|NA|NA	S	F420-0:Gamma-glutamyl ligase
MAG.T12.45_01402	1048339.KB913029_gene3575	1.9e-95	355.5	Actinobacteria	thyX		2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100		R06613	RC00022,RC00332	ko00000,ko00001,ko01000				Bacteria	2HCNJ@201174,COG1351@1,COG1351@2	NA|NA|NA	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant
MAG.T12.45_01403	1449353.JQMQ01000005_gene485	2.6e-11	74.7	Actinobacteria													Bacteria	2BNAP@1,2GTB3@201174,32GYA@2	NA|NA|NA		
MAG.T12.45_01404	743721.Psesu_0725	2.6e-159	568.2	Xanthomonadales	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Bacteria	1MU93@1224,1RMBM@1236,1X34S@135614,COG0057@1,COG0057@2	NA|NA|NA	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MAG.T12.45_01405	590998.Celf_1150	3.2e-127	461.8	Cellulomonadaceae	galK		2.7.1.6,2.7.7.12	ko:K00849,ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955,R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJXI@201174,4F1TD@85016,COG0153@1,COG0153@2	NA|NA|NA	G	Belongs to the GHMP kinase family. GalK subfamily
MAG.T12.45_01406	979556.MTES_2077	2.7e-192	678.3	Microbacteriaceae			3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603		R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000				Bacteria	2GJJ1@201174,4FKWH@85023,COG3345@1,COG3345@2	NA|NA|NA	G	Melibiase
MAG.T12.45_01408	1048339.KB913029_gene2814	4.4e-18	99.4	Frankiales													Bacteria	2GIVS@201174,4EW85@85013,COG1983@1,COG1983@2	NA|NA|NA	KT	PFAM PspC domain protein
MAG.T12.45_01409	58123.JOFJ01000019_gene3792	3.7e-67	262.3	Streptosporangiales	tcsS3												Bacteria	2GJ4J@201174,4EG3Q@85012,COG1983@1,COG1983@2,COG4585@1,COG4585@2	NA|NA|NA	KT	PspC domain
MAG.T12.45_01410	1394178.AWOO02000003_gene2641	1e-76	293.1	Streptosporangiales	degU			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2	NA|NA|NA	T	helix_turn_helix, Lux Regulon
MAG.T12.45_01411	1304865.JAGF01000001_gene590	1e-22	112.8	Bacteria													Bacteria	2E4PN@1,32ZIA@2	NA|NA|NA		
MAG.T12.45_01412	1146883.BLASA_4228	1.3e-75	289.7	Frankiales													Bacteria	2GMVD@201174,4ESNR@85013,COG2120@1,COG2120@2	NA|NA|NA	S	Evidence 2b Function of strongly homologous gene
MAG.T12.45_01413	1504319.GM45_2400	3.2e-46	193.0	Actinobacteria				ko:K01446			R04112	RC00064,RC00141	ko00000				Bacteria	2IG5X@201174,COG3409@1,COG3409@2	NA|NA|NA	M	Peptidoglycan-binding domain 1 protein
MAG.T12.45_01417	1157943.KB892705_gene3044	7.9e-51	207.6	Bacteria	cof												Bacteria	COG0561@1,COG0561@2	NA|NA|NA	Q	phosphatase activity
MAG.T12.45_01418	1171373.PACID_04150	3.3e-08	64.3	Propionibacteriales				ko:K00375					ko00000,ko03000				Bacteria	2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2	NA|NA|NA	K	helix_turn_helix gluconate operon transcriptional repressor
MAG.T12.45_01419	110319.CF8_2111	5.7e-74	284.3	Propionibacteriales	cphA		6.3.2.13,6.3.2.29,6.3.2.30	ko:K01928,ko:K03802	ko00300,ko00550,map00300,map00550		R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011				Bacteria	2GN0U@201174,4DP39@85009,COG0189@1,COG0189@2,COG0769@1,COG0769@2	NA|NA|NA	HJM	RimK-like ATP-grasp domain
MAG.T12.45_01420	1193181.BN10_1080036	9.6e-49	200.7	Intrasporangiaceae	murE		6.3.2.13,6.3.2.29,6.3.2.30	ko:K01928,ko:K03802	ko00300,ko00550,map00300,map00550		R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011				Bacteria	2GME3@201174,4FF9P@85021,COG0769@1,COG0769@2	NA|NA|NA	M	Tetratrico peptide repeat
MAG.T12.45_01423	1380354.JIAN01000009_gene3757	2.9e-11	75.1	Bacteria													Bacteria	COG4961@1,COG4961@2	NA|NA|NA	U	PFAM TadE family protein
MAG.T12.45_01425	408672.NBCG_01573	6.7e-48	197.6	Propionibacteriales													Bacteria	2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009	NA|NA|NA		
MAG.T12.45_01426	446471.Xcel_3424	2.7e-17	95.1	Promicromonosporaceae													Bacteria	2GRCJ@201174,4F5S5@85017,COG4961@1,COG4961@2	NA|NA|NA	U	TadE-like protein
MAG.T12.45_01427	1380347.JNII01000006_gene1628	2e-44	187.2	Actinobacteria													Bacteria	2GJAR@201174,COG2909@1,COG2909@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_01428	68570.DC74_256	1.6e-116	426.0	Actinobacteria	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GKRN@201174,COG2326@1,COG2326@2	NA|NA|NA	G	polyphosphate kinase
MAG.T12.45_01429	32049.SYNPCC7002_A1469	4.9e-38	164.5	Synechococcus		GO:0005575,GO:0005576,GO:0005615,GO:0044421											Bacteria	1G6R4@1117,1H17A@1129,COG2335@1,COG2335@2	NA|NA|NA	M	Fasciclin domain protein
MAG.T12.45_01430	1121272.KB903249_gene2575	5.3e-45	188.0	Micromonosporales	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GNW1@201174,4DD25@85008,COG2094@1,COG2094@2	NA|NA|NA	L	Belongs to the DNA glycosylase MPG family
MAG.T12.45_01431	477641.MODMU_2240	2.1e-81	309.7	Frankiales													Bacteria	2GN4Y@201174,4ETWR@85013,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T12.45_01432	1449044.JMLE01000005_gene690	1.4e-15	89.4	Actinobacteria	XK27_09090			ko:K09153					ko00000				Bacteria	2GQZ0@201174,COG2456@1,COG2456@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2304)
MAG.T12.45_01433	40571.JOEA01000010_gene3037	3.6e-73	281.6	Pseudonocardiales	ycbB			ko:K00786					ko00000,ko01000				Bacteria	2I2J1@201174,4DXD3@85010,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T12.45_01434	1283283.ATXA01000005_gene2041	8.4e-190	670.6	Frankiales													Bacteria	2GK30@201174,4ES04@85013,COG3973@1,COG3973@2	NA|NA|NA	L	DNA helicase
MAG.T12.45_01435	1110697.NCAST_20_05770	7.5e-59	233.8	Nocardiaceae													Bacteria	2IJG5@201174,4FVR0@85025,COG5587@1,COG5587@2	NA|NA|NA	S	Conserved hypothetical protein (DUF2461)
MAG.T12.45_01436	66429.JOFL01000013_gene2959	6.5e-74	283.5	Actinobacteria	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190				ko00000,ko00001,ko01000			iNJ661.Rv3628	Bacteria	2GM7F@201174,COG0221@1,COG0221@2	NA|NA|NA	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MAG.T12.45_01437	1906.SFRA_18710	8.7e-63	248.1	Actinobacteria	dacB		3.4.16.4	ko:K07259	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	2GJPH@201174,COG2027@1,COG2027@2	NA|NA|NA	M	D-alanyl-D-alanine carboxypeptidase
MAG.T12.45_01438	1210045.ALNP01000035_gene2435	1.5e-88	333.2	Actinobacteria													Bacteria	2GJ8E@201174,COG5282@1,COG5282@2	NA|NA|NA	S	protein, coenzyme F420 biosynthesis associated
MAG.T12.45_01439	269800.Tfu_2897	1e-67	263.8	Streptosporangiales	tilS		2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	2GJR4@201174,4EHNI@85012,COG0037@1,COG0037@2	NA|NA|NA	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MAG.T12.45_01440	1184607.AUCHE_03_01750	3.2e-74	284.6	Dermatophilaceae	hpt		2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	2GMDZ@201174,4F64W@85018,COG0634@1,COG0634@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T12.45_01441	4572.TRIUR3_22235-P1	2.2e-09	69.7	Eukaryota													Eukaryota	2D3XI@1,2ST4T@2759	NA|NA|NA		
MAG.T12.45_01442	1032480.MLP_51570	6.1e-101	374.0	Propionibacteriales				ko:K07243					ko00000,ko02000	2.A.108.1,2.A.108.2			Bacteria	2GJ22@201174,4DPYF@85009,COG0672@1,COG0672@2	NA|NA|NA	P	Iron permease FTR1 family
MAG.T12.45_01443	1961.JOAK01000020_gene7292	1.2e-41	177.2	Actinobacteria													Bacteria	2GN1H@201174,COG1680@1,COG1680@2	NA|NA|NA	V	Beta-lactamase
MAG.T12.45_01444	512565.AMIS_17490	2.1e-07	63.2	Micromonosporales													Bacteria	2GJKC@201174,4DBA8@85008,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_01445	1454010.JEOE01000004_gene180	4.7e-52	211.8	Actinobacteria				ko:K02529					ko00000,ko03000				Bacteria	2GQER@201174,COG1609@1,COG1609@2	NA|NA|NA	K	PFAM regulatory protein LacI
MAG.T12.45_01446	196162.Noca_2052	3e-59	235.0	Propionibacteriales			1.5.1.40	ko:K06988					ko00000,ko01000				Bacteria	2GMZ5@201174,4DQQN@85009,COG2085@1,COG2085@2	NA|NA|NA	S	NADP oxidoreductase coenzyme F420-dependent
MAG.T12.45_01447	1298863.AUEP01000004_gene1929	3.6e-59	234.6	Propionibacteriales													Bacteria	2GMV1@201174,4DQXT@85009,COG1846@1,COG1846@2	NA|NA|NA	K	Transcriptional regulator, MarR family
MAG.T12.45_01448	1089455.MOPEL_010_00010	4.9e-185	654.1	Dermatophilaceae													Bacteria	2H68X@201174,4F7DH@85018,COG3385@1,COG3385@2	NA|NA|NA	L	Transposase DDE domain group 1
MAG.T12.45_01450	1298863.AUEP01000019_gene3531	2e-23	115.2	Actinobacteria													Bacteria	2AEBM@1,2HDPF@201174,31462@2	NA|NA|NA		
MAG.T12.45_01451	1385518.N798_12125	1.6e-51	208.8	Intrasporangiaceae													Bacteria	2AKGE@1,2I885@201174,30DHP@2,4FH35@85021	NA|NA|NA		
MAG.T12.45_01452	1172188.KB911822_gene839	8.8e-56	223.0	Intrasporangiaceae													Bacteria	298UU@1,2HY02@201174,2ZVYZ@2,4FIZB@85021	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T12.45_01453	926564.KI911630_gene3158	8.1e-37	161.4	Promicromonosporaceae													Bacteria	2DM4W@1,2IK0R@201174,31QNY@2,4F4T1@85017	NA|NA|NA	S	Winged helix DNA-binding domain
MAG.T12.45_01454	1385518.N798_07485	1.3e-10	75.1	Intrasporangiaceae			3.2.1.4	ko:K01179,ko:K11904,ko:K20276	ko00500,ko01100,ko02024,ko03070,map00500,map01100,map02024,map03070	M00334	R06200,R11307,R11308		ko00000,ko00001,ko00002,ko01000,ko02044	3.A.23.1	GH5,GH9		Bacteria	2I7XV@201174,4FK2V@85021,COG4733@1,COG4733@2,COG4932@1,COG4932@2	NA|NA|NA	M	Fibronectin type III domain
MAG.T12.45_01455	1150398.JIBJ01000006_gene3690	1.1e-12	79.3	Actinobacteria													Bacteria	2DQ6J@1,2GTCR@201174,334Z3@2	NA|NA|NA	S	Excalibur calcium-binding domain
MAG.T12.45_01456	1123024.AUII01000004_gene1673	8e-14	82.8	Pseudonocardiales		GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136											Bacteria	2EH0W@1,2GSW1@201174,33ASY@2,4E7W5@85010	NA|NA|NA		
MAG.T12.45_01457	1120936.KB907216_gene3889	4e-144	517.7	Streptosporangiales	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1589,iZ_1308.Z0994	Bacteria	2GIUE@201174,4EHMR@85012,COG0502@1,COG0502@2	NA|NA|NA	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MAG.T12.45_01458	479432.Sros_8310	1.8e-63	249.6	Streptosporangiales	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47,6.3.3.3	ko:K00652,ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182,R03210,R10124	RC00004,RC00039,RC00868,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GIZ2@201174,4EIRW@85012,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MAG.T12.45_01459	1155718.KB891946_gene4633	1.6e-100	374.0	Actinobacteria													Bacteria	2ID4D@201174,COG2124@1,COG2124@2	NA|NA|NA	Q	Cytochrome P450
MAG.T12.45_01460	446470.Snas_0470	1.8e-152	545.8	Glycomycetales	bioA		2.6.1.105,2.6.1.62	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231,R10699	RC00006,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007			iSB619.SA_RS12705	Bacteria	2I2DN@201174,4EY5T@85014,COG0161@1,COG0161@2	NA|NA|NA	H	Aminotransferase class-III
MAG.T12.45_01461	367299.JOEE01000001_gene1505	3.2e-118	432.2	Intrasporangiaceae	enhA_2												Bacteria	2GQ7D@201174,4FIVF@85021,COG1376@1,COG1376@2	NA|NA|NA	S	Putative peptidoglycan binding domain
MAG.T12.45_01462	471855.Shel_11220	1.5e-66	260.0	Coriobacteriia	pta		2.3.1.8	ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ5U@201174,4CVRI@84998,COG0280@1,COG0280@2	NA|NA|NA	C	PFAM Phosphate acetyl butaryl transferase
MAG.T12.45_01464	991905.SL003B_1298	1.2e-35	156.0	Proteobacteria				ko:K07068					ko00000				Bacteria	1RJZS@1224,COG1545@1,COG1545@2	NA|NA|NA	S	Rubredoxin-like zinc ribbon domain (DUF35_N)
MAG.T12.45_01465	991905.SL003B_1297	6.1e-145	520.8	unclassified Alphaproteobacteria	phlC		2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MUZV@1224,2TRHF@28211,4BSJ0@82117,COG0183@1,COG0183@2	NA|NA|NA	I	acetyl-coa acetyltransferase
MAG.T12.45_01466	443218.AS9A_2735	2.6e-40	171.4	Mycobacteriaceae													Bacteria	239ZN@1762,2IQ55@201174,COG0640@1,COG0640@2	NA|NA|NA	K	regulatory protein, arsR
MAG.T12.45_01467	443218.AS9A_2736	9.4e-130	469.9	Mycobacteriaceae													Bacteria	236RA@1762,2I8ND@201174,COG3832@1,COG3832@2	NA|NA|NA	S	Activator of Hsp90 ATPase 1 family protein
MAG.T12.45_01468	1035308.AQYY01000001_gene3431	3e-124	451.4	Peptococcaceae	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35		Bacteria	1TQAJ@1239,248E1@186801,260JM@186807,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MAG.T12.45_01471	1122611.KB903963_gene4836	1.4e-122	446.0	Streptosporangiales													Bacteria	2GMHR@201174,4EGEB@85012,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T12.45_01473	1487953.JMKF01000043_gene2606	2.7e-25	122.1	Cyanobacteria				ko:K03712					ko00000,ko03000				Bacteria	1G8VK@1117,COG1846@1,COG1846@2	NA|NA|NA	K	helix_turn_helix multiple antibiotic resistance protein
MAG.T12.45_01477	287986.DV20_10395	8.8e-59	234.6	Pseudonocardiales				ko:K02027,ko:K17329	ko02010,map02010	M00207,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33			Bacteria	2GKM8@201174,4DYH5@85010,COG1653@1,COG1653@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
MAG.T12.45_01478	743718.Isova_2471	5.4e-68	264.2	Promicromonosporaceae	msrA		1.8.4.11	ko:K07304					ko00000,ko01000				Bacteria	2GJ1S@201174,4F34W@85017,COG0225@1,COG0225@2	NA|NA|NA	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAG.T12.45_01481	1205680.CAKO01000002_gene2132	4.3e-20	104.4	Rhodospirillales													Bacteria	1MZR5@1224,2JU1E@204441,2UCIB@28211,COG3339@1,COG3339@2	NA|NA|NA	S	Protein of unknown function (DUF1232)
MAG.T12.45_01482	469371.Tbis_1836	3.3e-166	591.7	Pseudonocardiales	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	2GJGI@201174,4DZ25@85010,COG4122@1,COG4122@2	NA|NA|NA	S	proteasome accessory factor PafA2
MAG.T12.45_01483	446466.Cfla_2002	1e-09	68.9	Cellulomonadaceae	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575		ko:K13570					ko00000,ko04121				Bacteria	2E9C2@1,2I1D6@201174,333JS@2,4F1MQ@85016	NA|NA|NA	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation
MAG.T12.45_01484	479435.Kfla_3226	6.5e-95	354.0	Propionibacteriales	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	2GJ60@201174,4DPD6@85009,COG0638@1,COG0638@2	NA|NA|NA	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
MAG.T12.45_01485	1184609.KILIM_006_00080	1.1e-79	303.1	Dermatophilaceae	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	2GKZ1@201174,4F6S2@85018,COG0638@1,COG0638@2	NA|NA|NA	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
MAG.T12.45_01486	1123320.KB889667_gene2950	1.1e-197	696.0	Actinobacteria	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	2GMC6@201174,COG0638@1,COG0638@2	NA|NA|NA	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAG.T12.45_01487	1229780.BN381_350110	1.5e-27	129.8	unclassified Actinobacteria (class)													Bacteria	2IHQC@201174,3UWVE@52018,COG0545@1,COG0545@2	NA|NA|NA	O	FKBP-type peptidyl-prolyl cis-trans isomerase
MAG.T12.45_01488	1150599.MPHLEI_21374	1.9e-43	181.8	Mycobacteriaceae	fkb		5.2.1.8	ko:K01802,ko:K03772					ko00000,ko01000,ko03110				Bacteria	239F5@1762,2IHQC@201174,COG0545@1,COG0545@2	NA|NA|NA	O	Peptidyl-prolyl cis-trans isomerase
MAG.T12.45_01489	1236902.ANAS01000037_gene5402	6.8e-87	328.6	Streptosporangiales	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K13572,ko:K13573					ko00000,ko03051				Bacteria	2GM46@201174,4EFRP@85012,COG2378@1,COG2378@2	NA|NA|NA	K	WYL domain
MAG.T12.45_01490	266940.Krad_1881	1.4e-16	92.4	Actinobacteria													Bacteria	2BZPH@1,2IQ4A@201174,33EX8@2	NA|NA|NA		
MAG.T12.45_01491	106370.Francci3_2305	6.1e-12	76.6	Frankiales	tatA			ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2GQQX@201174,4ETM8@85013,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MAG.T12.45_01492	1504319.GM45_0890	2.8e-63	248.8	unclassified Actinobacteria (class)	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2GJK8@201174,3UWSI@52018,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
MAG.T12.45_01493	1121272.KB903257_gene5486	3.3e-65	255.4	Micromonosporales	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110		R02240	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GK3P@201174,4D9SI@85008,COG1597@1,COG1597@2	NA|NA|NA	I	Diacylglycerol kinase
MAG.T12.45_01494	1123322.KB904647_gene1742	6.3e-301	1040.0	Actinobacteria	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K03727					ko00000,ko01000				Bacteria	2GJEX@201174,COG4581@1,COG4581@2	NA|NA|NA	L	DEAD DEAH box helicase
MAG.T12.45_01496	266940.Krad_1887	4.1e-87	328.2	Actinobacteria	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	2GKTZ@201174,COG0258@1,COG0258@2	NA|NA|NA	L	5'-3' exonuclease
MAG.T12.45_01497	436229.JOEH01000002_gene3343	2.4e-132	478.8	Streptacidiphilus	acdA			ko:K18244					ko00000,ko01000				Bacteria	2GIX8@201174,2NHRD@228398,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase, C-terminal domain
MAG.T12.45_01498	1896.JOAU01000013_gene1986	2.7e-52	211.5	Actinobacteria	lrp_3			ko:K03719					ko00000,ko03000,ko03036				Bacteria	2GK3G@201174,COG1522@1,COG1522@2	NA|NA|NA	K	asnC family
MAG.T12.45_01499	1298863.AUEP01000008_gene1335	2.6e-197	694.9	Propionibacteriales	kamA1		5.4.3.2	ko:K01843	ko00310,map00310		R00461	RC00303	ko00000,ko00001,ko01000				Bacteria	2GM2P@201174,4DP5B@85009,COG1509@1,COG1509@2	NA|NA|NA	E	lysine 2,3-aminomutase
MAG.T12.45_01500	219305.MCAG_00044	1.3e-124	453.0	Micromonosporales	kdd		1.4.1.11	ko:K18012	ko00310,map00310		R03349	RC00888	ko00000,ko00001,ko01000				Bacteria	2GK3U@201174,4DA07@85008,COG1063@1,COG1063@2	NA|NA|NA	E	Dehydrogenase
MAG.T12.45_01501	1463856.JOHY01000016_gene5622	1.3e-152	546.6	Actinobacteria	ytcJ												Bacteria	2GJVW@201174,COG1574@1,COG1574@2	NA|NA|NA	E	amidohydrolase
MAG.T12.45_01502	1120950.KB892708_gene4481	1.2e-222	779.2	Propionibacteriales	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4,5.4.3.3	ko:K01619,ko:K01844	ko00030,ko00310,map00030,map00310		R01066,R02852,R03275	RC00436,RC00437,RC00719	ko00000,ko00001,ko01000				Bacteria	2GUM7@201174,4DNH2@85009,COG0274@1,COG0274@2	NA|NA|NA	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit
MAG.T12.45_01503	1122609.AUGT01000003_gene2193	1.3e-94	352.8	Propionibacteriales	kamE		5.4.3.3,5.4.3.5	ko:K17898,ko:K18011	ko00310,ko00472,map00310,map00472		R02461,R02852,R03275	RC00719	ko00000,ko00001,ko01000				Bacteria	2HF50@201174,4DNBN@85009,COG2185@1,COG2185@2	NA|NA|NA	I	Dimerisation domain of d-ornithine 4,5-aminomutase
MAG.T12.45_01504	1120934.KB894404_gene715	2e-44	185.3	Pseudonocardiales			4.3.1.14	ko:K18014	ko00310,map00310		R03030	RC00833	ko00000,ko00001,ko01000				Bacteria	2IKM2@201174,4E3PP@85010,COG1607@1,COG1607@2	NA|NA|NA	I	Thioesterase superfamily
MAG.T12.45_01505	561175.KB894096_gene668	8.6e-112	411.0	Streptosporangiales	lnt			ko:K03820					ko00000,ko01000		GT2		Bacteria	2GJ9F@201174,4EHTJ@85012,COG0815@1,COG0815@2	NA|NA|NA	M	Transfers the fatty acyl group on membrane lipoproteins
MAG.T12.45_01506	452652.KSE_45450	2.4e-97	362.1	Kitasatospora	dpm1		2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	2I2FA@201174,2M0M1@2063,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
MAG.T12.45_01508	479433.Caci_5317	7.8e-34	149.8	Actinobacteria	rbpA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	2CNY9@1,2I80U@201174,31DSU@2	NA|NA|NA	K	RNA polymerase-binding protein
MAG.T12.45_01509	1288494.EBAPG3_12090	3.4e-15	89.4	Nitrosomonadales													Bacteria	1PWB7@1224,2BTJW@1,2WBVY@28216,32NSK@2,373WE@32003	NA|NA|NA		
MAG.T12.45_01510	1236902.ANAS01000037_gene5376	5.2e-59	234.6	Streptosporangiales	glpQ2		3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000				Bacteria	2GJ5W@201174,4EIE7@85012,COG0584@1,COG0584@2	NA|NA|NA	C	Glycerophosphoryl diester phosphodiesterase family
MAG.T12.45_01511	543632.JOJL01000020_gene553	6.5e-55	221.9	Micromonosporales				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T12.45_01512	446466.Cfla_3439	7.7e-98	363.6	Cellulomonadaceae	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147			iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	Bacteria	2GJJ0@201174,4F0TK@85016,COG0113@1,COG0113@2	NA|NA|NA	H	Belongs to the ALAD family
MAG.T12.45_01513	656024.FsymDg_4039	1.5e-170	605.9	Frankiales	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007			iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158	Bacteria	2GJSH@201174,4ERKP@85013,COG0001@1,COG0001@2	NA|NA|NA	H	PFAM Aminotransferase class-III
MAG.T12.45_01514	105420.BBPO01000037_gene311	2.5e-75	288.5	Streptacidiphilus		GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMXF@201174,2NFB7@228398,COG0406@1,COG0406@2	NA|NA|NA	G	Phosphoglycerate mutase family
MAG.T12.45_01515	269800.Tfu_2704	1.1e-43	183.3	Streptosporangiales	resA			ko:K02199					ko00000,ko03110				Bacteria	2GP7J@201174,4EJ9T@85012,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin-like
MAG.T12.45_01516	1236902.ANAS01000019_gene4144	2.5e-73	282.3	Streptosporangiales	ccdA			ko:K06196					ko00000,ko02000	5.A.1.2			Bacteria	2GJW3@201174,4EHWN@85012,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein transmembrane region
MAG.T12.45_01517	1120950.KB892801_gene1786	4.2e-127	461.8	Propionibacteriales	resB			ko:K07399					ko00000				Bacteria	2GMGH@201174,4DN12@85009,COG1333@1,COG1333@2	NA|NA|NA	O	ResB-like family
MAG.T12.45_01518	1048339.KB913029_gene2342	2.2e-79	302.8	Frankiales	ccsA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678											Bacteria	2GJR1@201174,4ESE9@85013,COG0755@1,COG0755@2	NA|NA|NA	O	Cytochrome c-type biogenesis protein
MAG.T12.45_01520	1120950.KB892801_gene1792	6.1e-12	77.4	Propionibacteriales													Bacteria	2EGDD@1,2HKYH@201174,33A58@2,4DSSA@85009	NA|NA|NA	S	Phospholipase_D-nuclease N-terminal
MAG.T12.45_01521	158189.SpiBuddy_1062	2.8e-50	204.9	Spirochaetes	btuE		1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918		R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000				Bacteria	2J843@203691,COG0386@1,COG0386@2	NA|NA|NA	C	Belongs to the glutathione peroxidase family
MAG.T12.45_01524	471852.Tcur_3372	7.5e-137	493.8	Streptosporangiales	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	Bacteria	2GIRV@201174,4EGGZ@85012,COG0743@1,COG0743@2	NA|NA|NA	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MAG.T12.45_01525	105425.BBPL01000080_gene4799	1.7e-113	416.4	Streptacidiphilus			1.2.1.3,1.2.1.9	ko:K00128,ko:K00131	ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00135,M00308,M00633	R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,2NG4B@228398,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T12.45_01526	105422.BBPM01000004_gene5337	1.4e-186	659.4	Streptacidiphilus	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03703	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GIS4@201174,2NEJF@228398,COG0322@1,COG0322@2	NA|NA|NA	L	GIY-YIG type nucleases (URI domain)
MAG.T12.45_01527	100226.SCO1952	5.2e-95	354.4	Actinobacteria	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K06958					ko00000,ko03019				Bacteria	2GMWB@201174,COG1660@1,COG1660@2	NA|NA|NA	S	Displays ATPase and GTPase activities
MAG.T12.45_01528	1380346.JNIH01000005_gene3152	6.8e-91	340.9	Actinobacteria	ybhK												Bacteria	2GJBW@201174,COG0391@1,COG0391@2	NA|NA|NA	S	Required for morphogenesis under gluconeogenic growth conditions
MAG.T12.45_01529	1123322.KB904653_gene803	2.2e-139	501.9	Actinobacteria	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944		ko:K09762					ko00000				Bacteria	2GJZU@201174,COG1481@1,COG1481@2	NA|NA|NA	K	May be required for sporulation
MAG.T12.45_01530	446471.Xcel_1549	2.9e-136	491.9	Promicromonosporaceae	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJC6@201174,4F49B@85017,COG0126@1,COG0126@2	NA|NA|NA	G	Phosphoglycerate kinase
MAG.T12.45_01531	500153.JOEK01000014_gene5647	9.2e-104	383.3	Actinobacteria	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJXZ@201174,COG0149@1,COG0149@2	NA|NA|NA	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MAG.T12.45_01532	1298863.AUEP01000005_gene2451	9.3e-17	92.4	Propionibacteriales	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	2GR31@201174,4DS3V@85009,COG1314@1,COG1314@2	NA|NA|NA	U	Preprotein translocase SecG subunit
MAG.T12.45_01533	100226.SCO1943	1.1e-42	179.1	Actinobacteria	rbpA												Bacteria	2CNY9@1,2IKKZ@201174,31GEE@2	NA|NA|NA	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters
MAG.T12.45_01534	452652.KSE_55490	1.3e-253	882.5	Kitasatospora	tkt		2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ1K@201174,2M2DG@2063,COG0021@1,COG0021@2	NA|NA|NA	G	Transketolase, thiamine diphosphate binding domain
MAG.T12.45_01535	710696.Intca_1695	4.7e-88	331.3	Intrasporangiaceae	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029				Bacteria	2GJMY@201174,4FEY1@85021,COG0109@1,COG0109@2	NA|NA|NA	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MAG.T12.45_01536	219305.MCAG_00019	5.9e-74	285.0	Micromonosporales			2.7.13.3	ko:K02484,ko:K07653	ko02020,map02020	M00460			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2I3U8@201174,4D9HY@85008,COG5002@1,COG5002@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T12.45_01537	512565.AMIS_40330	5.6e-81	307.4	Micromonosporales													Bacteria	2GMVN@201174,4D8W6@85008,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MAG.T12.45_01539	1121385.AQXW01000004_gene1221	1.1e-66	260.4	Dermacoccaceae	ctaA			ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4			Bacteria	1ZVU4@145357,2GJQX@201174,COG1612@1,COG1612@2	NA|NA|NA	O	Cytochrome oxidase assembly protein
MAG.T12.45_01540	1394178.AWOO02000020_gene7495	2.9e-49	202.2	Streptosporangiales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN6S@201174,4EI28@85012,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T12.45_01541	1137269.AZWL01000008_gene4672	1.1e-92	346.7	Actinobacteria	drrA_2			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJBF@201174,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_01542	479435.Kfla_3277	1.4e-58	233.0	Propionibacteriales	sufR												Bacteria	2GN8W@201174,4DQCB@85009,COG2345@1,COG2345@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01544	1435356.Y013_26430	7e-44	184.1	Nocardiaceae													Bacteria	2GM2V@201174,4FV1M@85025,COG0553@1,COG0553@2	NA|NA|NA	L	SNF2 family N-terminal domain
MAG.T12.45_01545	861360.AARI_08090	1.7e-46	192.6	Actinobacteria	pin	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360											Bacteria	2HSUX@201174,COG1961@1,COG1961@2	NA|NA|NA	L	Site-specific recombinases, DNA invertase Pin homologs
MAG.T12.45_01546	313589.JNB_00905	1.7e-60	238.8	Actinobacteria	ant		2.7.7.47	ko:K00984,ko:K19279					ko00000,ko01000,ko01504				Bacteria	2IQ25@201174,COG1708@1,COG1708@2	NA|NA|NA	S	Uncharacterised protein family (UPF0158)
MAG.T12.45_01547	1380370.JIBA01000011_gene3047	2.4e-151	541.6	Intrasporangiaceae				ko:K04763					ko00000,ko03036				Bacteria	2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_01548	1385520.N802_11490	1.2e-28	132.1	Intrasporangiaceae													Bacteria	2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021	NA|NA|NA	S	Ribbon-helix-helix protein, copG family
MAG.T12.45_01549	1348338.ADILRU_1152	2.6e-25	120.9	Microbacteriaceae													Bacteria	2C7CU@1,2IRTH@201174,33J7G@2,4FSJC@85023	NA|NA|NA		
MAG.T12.45_01551	1298863.AUEP01000020_gene3640	1e-37	162.5	Actinobacteria			2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Bacteria	2IQZC@201174,COG2329@1,COG2329@2	NA|NA|NA	S	Antibiotic biosynthesis monooxygenase
MAG.T12.45_01552	1223523.H340_07753	7.2e-71	273.9	Actinobacteria													Bacteria	2GMX2@201174,COG3382@1,COG3382@2	NA|NA|NA	S	B3 4 domain
MAG.T12.45_01553	1121019.AUMN01000020_gene1650	4.5e-53	214.5	Micrococcaceae													Bacteria	1WCG3@1268,2I3S1@201174,COG1476@1,COG1476@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T12.45_01554	290340.AAur_3965	5.9e-78	297.7	Micrococcaceae	rhtA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015195,GO:0015238,GO:0015318,GO:0015562,GO:0015565,GO:0015711,GO:0015804,GO:0015807,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K11939					ko00000,ko02000	2.A.7.3.6			Bacteria	1W96S@1268,2GJKB@201174,COG5006@1,COG5006@2	NA|NA|NA	S	EamA-like transporter family
MAG.T12.45_01555	1323361.JPOC01000040_gene4233	9.8e-72	276.6	Nocardiaceae	narH		1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1			Bacteria	2GJ8P@201174,4FUZU@85025,COG1140@1,COG1140@2	NA|NA|NA	C	Nitrate reductase beta subunit
MAG.T12.45_01556	1127134.NOCYR_4275	3.1e-45	188.7	Nocardiaceae	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373,ko:K17052	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687	Bacteria	2IAQV@201174,4FWCV@85025,COG2180@1,COG2180@2	NA|NA|NA	C	Nitrate reductase
MAG.T12.45_01557	1429046.RR21198_1930	3e-88	331.6	Nocardiaceae	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1		iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iSF_1195.SF1230,ic_1306.c1897	Bacteria	2GJVI@201174,4FWVI@85025,COG2181@1,COG2181@2	NA|NA|NA	C	nitrate reductase, gamma subunit
MAG.T12.45_01558	398513.BBNG_01119	2.4e-26	124.8	Bifidobacteriales													Bacteria	2IHSV@201174,4D0ZF@85004,COG1917@1,COG1917@2	NA|NA|NA	S	Cupin 2, conserved barrel domain protein
MAG.T12.45_01559	1385520.N802_11095	1.8e-92	345.5	Actinobacteria													Bacteria	2AAWD@1,2IG0D@201174,3109H@2	NA|NA|NA	S	Alkylmercury lyase
MAG.T12.45_01560	882083.SacmaDRAFT_4675	6.1e-44	184.5	Actinobacteria													Bacteria	2IAWJ@201174,COG2345@1,COG2345@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01561	754252.PFREUD_23710	3.5e-94	352.1	Actinobacteria	eryK												Bacteria	2IJFZ@201174,COG2124@1,COG2124@2	NA|NA|NA	C	Cytochrome P450
MAG.T12.45_01562	1276920.ADIAG_02147	1.7e-26	125.2	Actinobacteria													Bacteria	2GS7C@201174,COG4309@1,COG4309@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2249)
MAG.T12.45_01563	1211815.CBYP010000005_gene232	2.8e-10	72.4	Actinobacteria													Bacteria	2GVAC@201174,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAG.T12.45_01565	2045.KR76_15710	7.3e-07	60.5	Propionibacteriales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN8P@201174,4DP9K@85009,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T12.45_01567	446471.Xcel_1962	5.1e-57	227.6	Actinobacteria													Bacteria	28PII@1,2GTGX@201174,32WVR@2	NA|NA|NA	S	Protein of unknown function (DUF4255)
MAG.T12.45_01569	1146883.BLASA_3175	3.1e-46	191.8	Actinobacteria													Bacteria	2GTXG@201174,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_01570	1283287.KB822582_gene2945	2e-54	219.2	Actinobacteria													Bacteria	2I7QR@201174,COG4803@1,COG4803@2	NA|NA|NA	S	Protein of unknown function (DUF1269)
MAG.T12.45_01571	298653.Franean1_6932	2.1e-122	446.0	Frankiales	gntK	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944	2.3.1.82,2.7.1.12	ko:K00663,ko:K00851,ko:K07028	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200		R01737	RC00002,RC00017	ko00000,ko00001,ko01000,ko01504				Bacteria	2GM3U@201174,4EUNB@85013,COG0645@1,COG0645@2,COG2187@1,COG2187@2	NA|NA|NA	S	AAA domain
MAG.T12.45_01573	446471.Xcel_2560	8.2e-76	290.0	Promicromonosporaceae	rmlC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3465	Bacteria	2GMW4@201174,4F3ZC@85017,COG1898@1,COG1898@2	NA|NA|NA	M	dTDP-4-dehydrorhamnose 3,5-epimerase
MAG.T12.45_01574	1121272.KB903283_gene5123	2.3e-36	158.3	Actinobacteria													Bacteria	2IIQY@201174,COG1917@1,COG1917@2	NA|NA|NA	S	Cupin 2, conserved barrel domain protein
MAG.T12.45_01575	1463858.JOHR01000009_gene3366	2.5e-97	362.1	Actinobacteria	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNY8@201174,COG1091@1,COG1091@2	NA|NA|NA	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MAG.T12.45_01576	43354.JOIJ01000013_gene689	1.3e-142	512.7	Pseudonocardiales	rfbB		4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNDU@201174,4E023@85010,COG1088@1,COG1088@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MAG.T12.45_01577	1380393.JHVP01000002_gene1670	1.5e-115	422.5	Frankiales	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0334	Bacteria	2GP20@201174,4ETV6@85013,COG1209@1,COG1209@2	NA|NA|NA	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MAG.T12.45_01578	266940.Krad_0491	5.4e-127	461.5	Actinobacteria	slpD												Bacteria	2GJYS@201174,COG0596@1,COG0596@2	NA|NA|NA	NU	Alpha beta hydrolase
MAG.T12.45_01580	479435.Kfla_0588	1.3e-99	370.2	Propionibacteriales	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ8C@201174,4DNVR@85009,COG0470@1,COG0470@2	NA|NA|NA	L	DNA polymerase III
MAG.T12.45_01581	1101188.KI912155_gene1902	2.9e-51	208.8	Micrococcaceae	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	1W963@1268,2GNTI@201174,COG0125@1,COG0125@2	NA|NA|NA	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MAG.T12.45_01582	1463853.JOHW01000029_gene2655	5.3e-211	741.1	Actinobacteria	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168					ko00000,ko01000,ko03032,ko03400				Bacteria	2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAG.T12.45_01583	675635.Psed_6174	2.7e-169	601.7	Pseudonocardiales	fadI	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJI8@201174,4DXSK@85010,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T12.45_01584	1120946.AUBF01000012_gene1136	5.8e-144	517.3	Actinobacteria				ko:K10546	ko02010,map02010	M00216			ko00000,ko00001,ko00002,ko02000	3.A.1.2.5			Bacteria	2GKRE@201174,4D5CU@85005,COG4213@1,COG4213@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T12.45_01585	446466.Cfla_3403	7.1e-173	613.6	Cellulomonadaceae	gguB	GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0019321,GO:0031224,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944		ko:K10547	ko02010,map02010	M00216			ko00000,ko00001,ko00002,ko02000	3.A.1.2.5			Bacteria	2GJAH@201174,4F0VZ@85016,COG4214@1,COG4214@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_01586	218140.BPSY_1116	4.3e-22	110.2	Bifidobacteriales	gguA		3.6.3.17	ko:K10545,ko:K10548	ko02010,map02010	M00215,M00216			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4,3.A.1.2.5			Bacteria	2GJ3F@201174,4CZ8Y@85004,COG1129@1,COG1129@2	NA|NA|NA	G	ATPases associated with a variety of cellular activities
MAG.T12.45_01587	1156935.QWE_02920	3.7e-60	238.4	Rhizobiaceae	sfuB			ko:K02011	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	1MWEV@1224,2VEX7@28211,4BETJ@82115,COG1178@1,COG1178@2	NA|NA|NA	P	ABC-type Fe3 transport system, permease component
MAG.T12.45_01588	1120950.KB892769_gene5382	1.9e-27	128.6	Propionibacteriales	yraN			ko:K07460					ko00000				Bacteria	2IQ3X@201174,4DRQN@85009,COG0792@1,COG0792@2	NA|NA|NA	L	Belongs to the UPF0102 family
MAG.T12.45_01589	1043493.BBLU01000010_gene217	1.2e-121	443.7	Actinobacteria				ko:K07391					ko00000				Bacteria	2GJIQ@201174,COG0606@1,COG0606@2	NA|NA|NA	O	PFAM magnesium chelatase ChlI subunit
MAG.T12.45_01590	1386089.N865_10205	5.4e-78	298.1	Intrasporangiaceae	dprA		5.99.1.2	ko:K03168,ko:K04096					ko00000,ko01000,ko03032,ko03400				Bacteria	2GKDA@201174,4FEJX@85021,COG0758@1,COG0758@2	NA|NA|NA	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake
MAG.T12.45_01591	397278.JOJN01000001_gene2687	3.3e-92	345.1	Propionibacteriales	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	2GNDP@201174,4DN7T@85009,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family. XerC subfamily
MAG.T12.45_01592	351607.Acel_1546	3.7e-93	348.2	Frankiales	sigD			ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111				ko00000,ko00001,ko02035,ko03021				Bacteria	2GKBK@201174,4ERYG@85013,COG1191@1,COG1191@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T12.45_01593	570268.ANBB01000022_gene5213	9.7e-31	140.6	Streptosporangiales													Bacteria	2IQ64@201174,4EJY5@85012,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase family M23
MAG.T12.45_01594	1123322.KB904679_gene3221	3.6e-115	421.4	Actinobacteria	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GMYC@201174,COG0052@1,COG0052@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS2 family
MAG.T12.45_01595	446462.Amir_5910	1e-84	320.1	Pseudonocardiales	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02357					ko00000,ko03012,ko03029				Bacteria	2GK4M@201174,4DXP8@85010,COG0264@1,COG0264@2	NA|NA|NA	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MAG.T12.45_01596	1123320.KB889675_gene4072	2.9e-100	371.7	Actinobacteria	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100		R00158	RC00002	ko00000,ko00001,ko01000			iSB619.SA_RS06240	Bacteria	2GKWQ@201174,COG0528@1,COG0528@2	NA|NA|NA	F	Catalyzes the reversible phosphorylation of UMP to UDP
MAG.T12.45_01597	1123320.KB889675_gene4071	1.4e-69	269.2	Actinobacteria	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02838					ko00000,ko03012				Bacteria	2GJ9J@201174,COG0233@1,COG0233@2	NA|NA|NA	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MAG.T12.45_01598	65497.JODV01000002_gene4222	1.5e-70	273.1	Pseudonocardiales	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41,2.7.7.67	ko:K00981,ko:K07098,ko:K19664	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799,R08966	RC00002	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1397	Bacteria	2I7ZA@201174,4DYTX@85010,COG0575@1,COG0575@2	NA|NA|NA	I	Belongs to the CDS family
MAG.T12.45_01599	266940.Krad_1420	3.5e-147	528.1	Actinobacteria	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Bacteria	2GJ48@201174,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MAG.T12.45_01600	1035308.AQYY01000001_gene1460	1.2e-33	149.1	Bacteria			4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100		R00346	RC02741	ko00000,ko00001,ko01000				Bacteria	28HY3@1,2Z83I@2	NA|NA|NA	S	phosphoenolpyruvate carboxykinase (diphosphate) activity
MAG.T12.45_01603	1306174.JODP01000013_gene7455	3.1e-102	378.6	Actinobacteria				ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMAY@201174,COG0559@1,COG0559@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_01604	1306174.JODP01000013_gene7456	1.2e-36	159.5	Actinobacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GM00@201174,COG0683@1,COG0683@2	NA|NA|NA	E	PFAM Extracellular ligand-binding receptor
MAG.T12.45_01607	1120949.KB903294_gene4303	3e-192	678.3	Micromonosporales				ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	2GJCB@201174,4D9U7@85008,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate permease family
MAG.T12.45_01608	1123377.AUIV01000016_gene295	7.2e-57	228.8	Gammaproteobacteria													Bacteria	1R7HC@1224,1T5UV@1236,COG2199@1,COG2202@1,COG2202@2,COG3706@2	NA|NA|NA	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MAG.T12.45_01609	2045.KR76_02335	6.6e-25	122.9	Propionibacteriales													Bacteria	2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T12.45_01612	1380354.JIAN01000005_gene2705	0.0	1347.0	Cellulomonadaceae	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	Bacteria	2GKE0@201174,4F1Q9@85016,COG1190@1,COG1190@2,COG2898@1,COG2898@2	NA|NA|NA	J	Uncharacterised conserved protein (DUF2156)
MAG.T12.45_01614	1440774.Y900_021210	1.5e-19	101.7	Mycobacteriaceae													Bacteria	23BC4@1762,2EUTX@1,2GRIM@201174,33N9F@2	NA|NA|NA	S	Protein of unknown function (DUF3618)
MAG.T12.45_01617	1101188.KI912157_gene288	6.2e-14	83.6	Actinobacteria													Bacteria	2BH0A@1,2GUIE@201174,32B0E@2	NA|NA|NA		
MAG.T12.45_01618	1449976.KALB_374	2.8e-09	68.9	Pseudonocardiales													Bacteria	2IFSD@201174,4E6ND@85010,COG1476@1,COG1476@2	NA|NA|NA	K	transcriptional regulators
MAG.T12.45_01619	1048339.KB913029_gene158	2.2e-28	133.3	Frankiales													Bacteria	2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2	NA|NA|NA	MT	Transglycosylase SLT domain
MAG.T12.45_01620	710696.Intca_3501	4.3e-32	143.7	Intrasporangiaceae				ko:K06218					ko00000,ko02048				Bacteria	2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2	NA|NA|NA	DJ	ParE toxin of type II toxin-antitoxin system, parDE
MAG.T12.45_01621	710696.Intca_3502	1.6e-31	141.7	Intrasporangiaceae			2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048				Bacteria	2GRC8@201174,4FJ8S@85021,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T12.45_01624	710696.Intca_0451	1.1e-301	1042.3	Intrasporangiaceae			3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31		Bacteria	2GP4V@201174,4FG4A@85021,COG1501@1,COG1501@2	NA|NA|NA	G	Glycosyl hydrolases family 31
MAG.T12.45_01625	446471.Xcel_0725	5.4e-21	107.8	Promicromonosporaceae													Bacteria	2IRV0@201174,4F4YK@85017,COG0542@1,COG0542@2	NA|NA|NA	O	Clp amino terminal domain, pathogenicity island component
MAG.T12.45_01626	749927.AMED_5979	3.3e-13	80.5	Pseudonocardiales													Bacteria	2E3V5@1,2GTV6@201174,345UQ@2,4ED36@85010	NA|NA|NA	S	Homeodomain-like domain
MAG.T12.45_01628	1386089.N865_19910	3.2e-119	435.3	Intrasporangiaceae				ko:K07222					ko00000				Bacteria	2GM3S@201174,4FFFI@85021,COG2072@1,COG2072@2	NA|NA|NA	P	L-lysine 6-monooxygenase (NADPH-requiring)
MAG.T12.45_01630	710111.FraQA3DRAFT_1948	7.6e-107	394.0	Frankiales													Bacteria	28H9S@1,2HZP4@201174,2Z7ME@2,4EU66@85013	NA|NA|NA	S	GDSL-like Lipase/Acylhydrolase
MAG.T12.45_01632	196162.Noca_1067	9.6e-91	340.5	Propionibacteriales	modC		2.10.1.1,3.6.3.29,3.6.3.55	ko:K02017,ko:K02018,ko:K03750,ko:K15497	ko00790,ko01100,ko02010,map00790,map01100,map02010	M00189,M00423	R09735,R10531	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8			Bacteria	2H2JF@201174,4DPFC@85009,COG3842@1,COG3842@2	NA|NA|NA	P	TOBE domain
MAG.T12.45_01633	446471.Xcel_2809	8.4e-84	317.0	Promicromonosporaceae	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8		iECO103_1326.ECO103_0752	Bacteria	2GJFB@201174,4F4A9@85017,COG4149@1,COG4149@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T12.45_01634	1194972.MVAC_29845	4.5e-64	251.5	Mycobacteriaceae	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704		ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	234BP@1762,2GMPF@201174,COG0725@1,COG0725@2	NA|NA|NA	P	ABC transporter, periplasmic molybdate-binding protein
MAG.T12.45_01635	1869.MB27_37345	3.5e-09	67.4	Micromonosporales	moaD		2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000				Bacteria	2IQIT@201174,4DFX3@85008,COG1977@1,COG1977@2	NA|NA|NA	H	ThiS family
MAG.T12.45_01636	1193181.BN10_1080031	1.2e-44	186.0	Intrasporangiaceae	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000				Bacteria	2GN0V@201174,4FFGU@85021,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAG.T12.45_01640	1463841.JOIR01000023_gene495	1.4e-87	329.3	Actinobacteria	ugd		1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJQB@201174,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T12.45_01641	1896.JOAU01000015_gene2030	4.6e-59	234.2	Actinobacteria	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000			iJN678.purE,iNJ661.Rv3275c	Bacteria	2IFFD@201174,COG0041@1,COG0041@2	NA|NA|NA	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MAG.T12.45_01642	1123320.KB889719_gene7401	3.9e-127	461.5	Actinobacteria	purK	GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477	Bacteria	2GJCU@201174,COG0026@1,COG0026@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MAG.T12.45_01643	2002.JOEQ01000052_gene8351	7.1e-76	290.8	Streptosporangiales	tagG			ko:K09690,ko:K09692	ko02010,map02010	M00250,M00251			ko00000,ko00001,ko00002,ko02000	3.A.1.103,3.A.1.104			Bacteria	2GP5K@201174,4EHWE@85012,COG1682@1,COG1682@2	NA|NA|NA	GM	ABC-2 type transporter
MAG.T12.45_01644	479435.Kfla_1567	1.1e-83	317.0	Propionibacteriales	tagH		3.6.3.38,3.6.3.40	ko:K09689,ko:K09691,ko:K09693	ko02010,map02010	M00249,M00250,M00251			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103,3.A.1.104			Bacteria	2GIVF@201174,4DPY7@85009,COG1134@1,COG1134@2	NA|NA|NA	GM	ATPases associated with a variety of cellular activities
MAG.T12.45_01645	879212.DespoDRAFT_01603	7.8e-45	187.6	Desulfobacterales	gluQ		6.1.1.17	ko:K01885,ko:K01894	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016				Bacteria	1MUN7@1224,2MNAB@213118,2WV4B@28221,42NQ8@68525,COG0008@1,COG0008@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
MAG.T12.45_01646	937777.Deipe_0380	7.6e-82	310.5	Deinococcus-Thermus	namA		1.6.99.1	ko:K00354			R00282	RC00001	ko00000,ko01000				Bacteria	1WIIR@1297,COG1902@1,COG1902@2	NA|NA|NA	C	PFAM NADH flavin oxidoreductase NADH oxidase
MAG.T12.45_01647	935866.JAER01000008_gene934	2e-178	632.1	Propionibacteriales			2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100		R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000				Bacteria	2I2F3@201174,4DP1H@85009,COG0160@1,COG0160@2	NA|NA|NA	E	Aminotransferase class-III
MAG.T12.45_01650	58123.JOFJ01000001_gene3316	7.3e-118	430.3	Streptosporangiales	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110		R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006				Bacteria	2GIXF@201174,4EG00@85012,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAG.T12.45_01651	397278.JOJN01000001_gene3042	7.3e-28	130.6	Propionibacteriales													Bacteria	2GWCE@201174,4DV6A@85009,COG2453@1,COG2453@2	NA|NA|NA	T	Dual specificity phosphatase, catalytic domain
MAG.T12.45_01652	471853.Bcav_1766	2.9e-83	315.1	Actinobacteria	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944		ko:K03584	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	2GK81@201174,COG1381@1,COG1381@2	NA|NA|NA	L	Involved in DNA repair and RecF pathway recombination
MAG.T12.45_01653	1172188.KB911821_gene1489	5.5e-82	311.6	Intrasporangiaceae													Bacteria	2GN4Y@201174,4FF71@85021,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T12.45_01654	526225.Gobs_3844	4.5e-141	508.1	Frankiales	deaD		3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GIUR@201174,4ES4U@85013,COG0513@1,COG0513@2	NA|NA|NA	L	DEAD DEAH box helicase domain protein
MAG.T12.45_01655	1463856.JOHY01000067_gene7125	3.7e-115	421.4	Actinobacteria	era	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363		ko:K03595					ko00000,ko03009,ko03029				Bacteria	2GJJE@201174,COG1159@1,COG1159@2	NA|NA|NA	M	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MAG.T12.45_01656	1120936.KB907220_gene1928	1.6e-119	436.4	Streptosporangiales	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GIWR@201174,4EFYG@85012,COG1253@1,COG1253@2	NA|NA|NA	S	Transporter associated domain
MAG.T12.45_01657	570268.ANBB01000046_gene1392	8.7e-46	189.9	Streptosporangiales	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029				Bacteria	2GMUF@201174,4EIYX@85012,COG0319@1,COG0319@2	NA|NA|NA	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MAG.T12.45_01658	1122609.AUGT01000023_gene513	1.8e-131	475.7	Propionibacteriales	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06217					ko00000				Bacteria	2GK0W@201174,4DPI2@85009,COG1702@1,COG1702@2	NA|NA|NA	T	PhoH-like protein
MAG.T12.45_01659	40571.JOEA01000016_gene46	5.9e-31	140.2	Pseudonocardiales	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.1.226,2.1.1.227	ko:K02503,ko:K06442					ko00000,ko01000,ko03009,ko04147				Bacteria	2IHPT@201174,4E5MT@85010,COG0537@1,COG0537@2	NA|NA|NA	FG	HIT family hydrolase, diadenosine tetraphosphate hydrolase
MAG.T12.45_01660	67352.JODS01000019_gene2705	6.2e-65	254.2	Actinobacteria	rsmE		1.13.12.16,2.1.1.193	ko:K00459,ko:K09761	ko00910,map00910		R00025	RC02541,RC02759	ko00000,ko00001,ko01000,ko03009				Bacteria	2GTKX@201174,COG1385@1,COG1385@2	NA|NA|NA	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MAG.T12.45_01661	47763.JNZA01000003_gene3958	9.9e-147	526.6	Actinobacteria	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944		ko:K03686					ko00000,ko03029,ko03110				Bacteria	2GK69@201174,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MAG.T12.45_01662	1134445.AJJM01000004_gene3443	1.7e-118	432.6	Actinobacteria	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03705					ko00000,ko03000				Bacteria	2GKF5@201174,COG1420@1,COG1420@2	NA|NA|NA	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MAG.T12.45_01663	58344.JOEL01000008_gene1598	6.3e-90	337.4	Actinobacteria	trpH	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360	3.1.3.97	ko:K07053			R00188,R11188	RC00078	ko00000,ko01000				Bacteria	2GIZ5@201174,COG0613@1,COG0613@2	NA|NA|NA	S	Protein of unknown function (DUF3097)
MAG.T12.45_01664	1123508.JH636440_gene2073	5.8e-09	67.8	Planctomycetes													Bacteria	2J1MD@203682,COG2314@1,COG2314@2	NA|NA|NA	S	TM2 domain
MAG.T12.45_01665	1120950.KB892739_gene4000	5.2e-130	471.1	Propionibacteriales	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576										iNJ661.Rv2388c	Bacteria	2GJXX@201174,4DN32@85009,COG0635@1,COG0635@2	NA|NA|NA	H	Involved in the biosynthesis of porphyrin-containing compound
MAG.T12.45_01667	235985.BBPN01000004_gene3182	2.8e-36	157.9	Streptacidiphilus	lolD			ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GM25@201174,2NFXP@228398,COG1136@1,COG1136@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T12.45_01668	867903.ThesuDRAFT_01213	5.5e-129	468.0	Clostridiales incertae sedis	fumC		4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Bacteria	1UHPH@1239,25F3I@186801,3WCCI@538999,COG0114@1,COG0114@2	NA|NA|NA	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MAG.T12.45_01669	1032480.MLP_14960	1.7e-67	262.3	Propionibacteriales	def		3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	2GJ87@201174,4DQAV@85009,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MAG.T12.45_01670	526225.Gobs_4775	8.9e-64	250.8	Frankiales	rsgA		3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100		R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009				Bacteria	2GMDX@201174,4EU3D@85013,COG1162@1,COG1162@2	NA|NA|NA	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MAG.T12.45_01672	935866.JAER01000027_gene4225	1.5e-41	176.0	Propionibacteriales													Bacteria	2IME3@201174,4DWV7@85009,COG2716@1,COG2716@2	NA|NA|NA	E	ACT domain
MAG.T12.45_01673	1894.JOER01000022_gene3926	3.6e-96	359.0	Actinobacteria			3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120		R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000				Bacteria	2GKPZ@201174,COG0154@1,COG0154@2	NA|NA|NA	J	Belongs to the amidase family
MAG.T12.45_01674	420324.KI912044_gene3963	8.2e-28	131.0	Methylobacteriaceae				ko:K06889					ko00000				Bacteria	1JTW5@119045,1NXZW@1224,2TSEE@28211,COG1073@1,COG1073@2	NA|NA|NA	S	Uncharacterised protein family (UPF0227)
MAG.T12.45_01675	103733.JNYO01000021_gene6755	1.8e-31	143.7	Actinobacteria													Bacteria	2H3FK@201174,COG2199@1,COG3706@2,COG5001@1,COG5001@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_01676	1125973.JNLC01000006_gene3027	1.3e-81	309.3	Alphaproteobacteria	pfpI		3.5.1.124	ko:K05520					ko00000,ko01000,ko01002				Bacteria	1MY0C@1224,2TU62@28211,COG0693@1,COG0693@2	NA|NA|NA	S	Intracellular protease
MAG.T12.45_01677	1278078.G419_24269	9.9e-63	246.5	Nocardiaceae													Bacteria	2GNR0@201174,4FXM7@85025,COG2119@1,COG2119@2	NA|NA|NA	S	Uncharacterized protein family UPF0016
MAG.T12.45_01678	1108045.GORHZ_141_00770	2.6e-13	80.9	Actinobacteria													Bacteria	2EMYX@1,2GZ6D@201174,33FM2@2	NA|NA|NA		
MAG.T12.45_01679	1463901.JOIY01000037_gene7073	4.2e-52	211.8	Actinobacteria													Bacteria	2H9P8@201174,COG0697@1,COG0697@2	NA|NA|NA	EG	spore germination
MAG.T12.45_01680	1304876.AZVC01000001_gene1260	2.8e-27	128.3	Micrococcaceae													Bacteria	1WA7S@1268,2IQEW@201174,COG1725@1,COG1725@2	NA|NA|NA	K	helix_turn_helix gluconate operon transcriptional repressor
MAG.T12.45_01681	446466.Cfla_1316	2.4e-20	106.3	Actinobacteria													Bacteria	2ERYQ@1,2GXQP@201174,33JHV@2	NA|NA|NA		
MAG.T12.45_01682	1123258.AQXZ01000019_gene3032	8.2e-105	387.5	Nocardiaceae													Bacteria	2I5AX@201174,4FX6Y@85025,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T12.45_01683	66377.JOBH01000017_gene2936	1e-121	443.4	Actinobacteria				ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Bacteria	2H4BW@201174,COG4608@1,COG4608@2	NA|NA|NA	E	Belongs to the ABC transporter superfamily
MAG.T12.45_01684	1048339.KB913029_gene2175	4e-27	129.0	Frankiales	bldKE			ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Bacteria	2H4BW@201174,4EUB4@85013,COG4608@1,COG4608@2	NA|NA|NA	P	Oligopeptide/dipeptide transporter, C-terminal region
MAG.T12.45_01685	1449353.JQMQ01000005_gene2404	1.1e-97	363.2	Streptacidiphilus	mshB		3.5.1.103	ko:K15525					ko00000,ko01000				Bacteria	2GKUM@201174,2NET5@228398,COG2120@1,COG2120@2	NA|NA|NA	S	GlcNAc-PI de-N-acetylase
MAG.T12.45_01686	68223.JNZY01000001_gene5613	6.6e-75	287.3	Actinobacteria	ppgK		2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJA0@201174,COG1940@1,COG1940@2	NA|NA|NA	GK	polyphosphate glucokinase
MAG.T12.45_01687	266940.Krad_1135	2.7e-197	695.3	Actinobacteria	ftsH			ko:K03798		M00742			ko00000,ko00002,ko01000,ko01002,ko03110				Bacteria	2I9X7@201174,COG0465@1,COG0465@2	NA|NA|NA	O	Belongs to the AAA ATPase family
MAG.T12.45_01688	710696.Intca_2606	4.6e-41	173.7	Intrasporangiaceae	gltA		2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ7E@201174,4FEQ1@85021,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T12.45_01689	1122609.AUGT01000005_gene1828	1.1e-14	86.7	Actinobacteria													Bacteria	2BIFQ@1,2IN70@201174,32CNA@2	NA|NA|NA		
MAG.T12.45_01691	710111.FraQA3DRAFT_5821	2e-42	178.7	Frankiales	iscR		2.8.1.7	ko:K04487,ko:K13643	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029				Bacteria	2INF3@201174,4ESZ6@85013,COG1959@1,COG1959@2	NA|NA|NA	K	transcriptional regulator, Rrf2 family
MAG.T12.45_01693	391037.Sare_1005	1.1e-59	236.1	Micromonosporales	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564					ko00000,ko01000			iPC815.YPO3064	Bacteria	2IHZ6@201174,4D9TD@85008,COG1225@1,COG1225@2	NA|NA|NA	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAG.T12.45_01696	195250.CM001776_gene2666	1.3e-21	110.9	Synechococcus	tir		3.4.11.19	ko:K01266,ko:K07052					ko00000,ko01000,ko01002				Bacteria	1G6D9@1117,1H119@1129,COG1266@1,COG1266@2	NA|NA|NA	S	CAAX protease self-immunity
MAG.T12.45_01697	1385518.N798_04100	1.4e-14	86.7	Intrasporangiaceae													Bacteria	2GTTI@201174,4FGNQ@85021,COG3976@1,COG3976@2	NA|NA|NA	S	FMN_bind
MAG.T12.45_01698	1380390.JIAT01000011_gene2397	4.1e-110	405.2	Rubrobacteria													Bacteria	2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2	NA|NA|NA	P	FAD-binding domain
MAG.T12.45_01699	1214242.B446_25490	1.6e-74	287.0	Actinobacteria	treS		2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16	ko:K00700,ko:K05343,ko:K16146	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01557,R02108,R02110,R02112,R09945,R11262	RC00002,RC00078,RC01816	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	2GKAP@201174,COG3281@1,COG3281@2	NA|NA|NA	G	protein, probably involved in trehalose biosynthesis
MAG.T12.45_01700	1463864.JOGO01000009_gene433	1.6e-51	209.1	Actinobacteria													Bacteria	299E4@1,2GM90@201174,2ZWGX@2	NA|NA|NA	S	Protein of unknown function (DUF3145)
MAG.T12.45_01701	253839.SSNG_05645	7e-167	593.6	Actinobacteria	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ4U@201174,COG0192@1,COG0192@2	NA|NA|NA	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MAG.T12.45_01702	477641.MODMU_3312	4.9e-128	464.5	Frankiales	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJGJ@201174,4ERES@85013,COG0452@1,COG0452@2	NA|NA|NA	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MAG.T12.45_01703	1306174.JODP01000013_gene7494	1.9e-32	144.8	Actinobacteria	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2IQHU@201174,COG1758@1,COG1758@2	NA|NA|NA	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MAG.T12.45_01704	221359.RS9916_33432	1.5e-55	222.6	Synechococcus	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Bacteria	1G515@1117,1GZ3I@1129,COG0194@1,COG0194@2	NA|NA|NA	F	Essential for recycling GMP and indirectly, cGMP
MAG.T12.45_01705	1150398.JIBJ01000004_gene2893	1.2e-13	82.8	Micrococcaceae	mihF		2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	1W9UW@1268,2IKPU@201174,COG0099@1,COG0099@2	NA|NA|NA	J	integration host factor
MAG.T12.45_01706	269800.Tfu_1060	2.1e-14	84.3	Streptosporangiales	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	Bacteria	2HPEA@201174,4EHE6@85012,COG0284@1,COG0284@2	NA|NA|NA	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MAG.T12.45_01707	1121946.AUAX01000005_gene5154	9.2e-49	199.5	Micromonosporales	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	2GKC9@201174,4D901@85008,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MAG.T12.45_01708	136273.GY22_15155	4.2e-26	124.4	Micrococcaceae													Bacteria	1W9Y1@1268,2CR5C@1,2IT0H@201174,32SNF@2	NA|NA|NA		
MAG.T12.45_01709	1048339.KB913029_gene2124	1.2e-82	313.5	Frankiales	gpgS		2.4.1.266,2.4.1.268	ko:K13693,ko:K21349					ko00000,ko01000,ko01003		GT81		Bacteria	2GMKV@201174,4ES7J@85013,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T12.45_01710	593907.Celgi_0422	1.8e-31	141.7	Cellulomonadaceae													Bacteria	2CUM0@1,2IQG7@201174,32SVJ@2,4F1EW@85016	NA|NA|NA	S	Protein of unknown function (DUF3263)
MAG.T12.45_01711	1121271.AUCM01000003_gene1485	1.4e-42	180.6	Alphaproteobacteria	yhhW			ko:K06911					ko00000				Bacteria	1MWIP@1224,2TRHR@28211,COG1741@1,COG1741@2	NA|NA|NA	L	Belongs to the pirin family
MAG.T12.45_01712	1122214.AQWH01000049_gene4711	2.8e-45	188.0	Alphaproteobacteria	tauX			ko:K07255,ko:K21700	ko00430,map00430		R01685	RC00062	ko00000,ko00001,ko01000				Bacteria	1RE9H@1224,2UACM@28211,COG3631@1,COG3631@2	NA|NA|NA	S	SnoaL-like polyketide cyclase
MAG.T12.45_01713	1146883.BLASA_2279	1.3e-19	102.4	Frankiales	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM7Z@201174,4ERSM@85013,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MAG.T12.45_01714	1157635.KB892057_gene5130	3.6e-101	374.8	Actinobacteria	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIVV@201174,COG0134@1,COG0134@2	NA|NA|NA	E	Belongs to the TrpC family
MAG.T12.45_01715	1463858.JOHR01000007_gene676	5.7e-15	87.4	Actinobacteria													Bacteria	2E37T@1,2GQH5@201174,32Y7G@2	NA|NA|NA	S	Protein of unknown function (DUF2752)
MAG.T12.45_01716	298653.Franean1_1613	8.3e-90	337.8	Frankiales													Bacteria	2I53J@201174,4EU80@85013,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_01717	1463825.JNXC01000005_gene2492	3e-82	311.6	Pseudonocardiales													Bacteria	2GJE6@201174,4DZNW@85010,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T12.45_01719	1157637.KB892090_gene6561	1.6e-184	652.5	Actinobacteria	trpE		4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKJT@201174,COG0147@1,COG0147@2	NA|NA|NA	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MAG.T12.45_01720	1236902.ANAS01000018_gene3245	7.2e-31	140.2	Streptosporangiales	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1606	Bacteria	2IKKU@201174,4EJM8@85012,COG0139@1,COG0139@2	NA|NA|NA	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MAG.T12.45_01721	1449347.JQLN01000007_gene1639	8.5e-105	386.7	Kitasatospora	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIRP@201174,2M09X@2063,COG0107@1,COG0107@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MAG.T12.45_01722	1120948.KB903243_gene2486	3.6e-14	84.3	Pseudonocardiales													Bacteria	2E35Q@1,2GS2Q@201174,32Y5M@2,4E724@85010	NA|NA|NA	S	Short C-terminal domain
MAG.T12.45_01723	227882.SAV_1926	7.5e-39	166.8	Actinobacteria													Bacteria	2IIN1@201174,COG4803@1,COG4803@2	NA|NA|NA	S	membrane protein of uknown function UCP014873
MAG.T12.45_01724	1385517.N800_12005	2.1e-63	250.4	Xanthomonadales	aarF			ko:K03688					ko00000				Bacteria	1MU1Z@1224,1RNQ9@1236,1X410@135614,COG0661@1,COG0661@2	NA|NA|NA	S	Ubiquinone biosynthesis protein
MAG.T12.45_01726	1380347.JNII01000008_gene4164	5.4e-26	124.0	Frankiales			4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130		R06602	RC01549,RC02148	ko00000,ko00001,ko01000				Bacteria	2IIB2@201174,4ETK2@85013,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
MAG.T12.45_01727	561175.KB894098_gene5366	3.6e-105	387.9	Streptosporangiales	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ4V@201174,4EGBG@85012,COG0106@1,COG0106@2	NA|NA|NA	E	Histidine biosynthesis protein
MAG.T12.45_01728	1120960.ATXG01000009_gene10	2.1e-82	312.0	Microbacteriaceae	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIYS@201174,4FKZP@85023,COG0118@1,COG0118@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MAG.T12.45_01729	710111.FraQA3DRAFT_6511	1.4e-75	289.3	Frankiales	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19	ko:K00013,ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457	RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007			iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570	Bacteria	2GKMD@201174,4ESDH@85013,COG0131@1,COG0131@2	NA|NA|NA	E	Imidazoleglycerol-phosphate dehydratase
MAG.T12.45_01730	408672.NBCG_04907	1.1e-121	443.4	Propionibacteriales	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJ9W@201174,4DPP5@85009,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MAG.T12.45_01731	1996.JOFO01000003_gene6293	2.3e-163	582.0	Streptosporangiales	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKKA@201174,4EHY2@85012,COG0141@1,COG0141@2	NA|NA|NA	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MAG.T12.45_01732	1048339.KB913029_gene4558	9e-39	167.2	Frankiales	lonD		3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	2GNWA@201174,4ET5K@85013,COG2802@1,COG2802@2	NA|NA|NA	S	Peptidase S16, lon domain protein
MAG.T12.45_01733	1123320.KB889675_gene3833	2.1e-48	198.7	Actinobacteria	ybaK	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K03976					ko00000,ko01000,ko03016				Bacteria	2IHS8@201174,COG2606@1,COG2606@2	NA|NA|NA	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MAG.T12.45_01734	351607.Acel_1054	0.0	1630.2	Frankiales	dnaE		2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2	NA|NA|NA	L	DNA polymerase III alpha subunit
MAG.T12.45_01735	483219.LILAB_07875	3.5e-177	628.2	Myxococcales	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MUR8@1224,2WJF1@28221,2YZGJ@29,42MKE@68525,COG2759@1,COG2759@2	NA|NA|NA	F	Belongs to the formate--tetrahydrofolate ligase family
MAG.T12.45_01736	471852.Tcur_0033	4e-103	381.3	Streptosporangiales	ydbC		1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120		R01708	RC00116	ko00000,ko00001,ko01000				Bacteria	2GJ6R@201174,4EICB@85012,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo/keto reductase family
MAG.T12.45_01737	593907.Celgi_1985	1.8e-95	355.5	Cellulomonadaceae	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180					ko00000,ko01000,ko03009,ko03016			iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	Bacteria	2GIY1@201174,4F1PZ@85016,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
MAG.T12.45_01738	436229.JOEH01000016_gene7218	1.7e-57	229.9	Streptacidiphilus	nudC		3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000				Bacteria	2GJZY@201174,2NF9K@228398,COG2816@1,COG2816@2	NA|NA|NA	L	NADH pyrophosphatase-like rudimentary NUDIX domain
MAG.T12.45_01739	1123320.KB889672_gene3701	8.6e-57	227.6	Actinobacteria													Bacteria	2GP3V@201174,COG3568@1,COG3568@2	NA|NA|NA	L	endonuclease exonuclease phosphatase
MAG.T12.45_01740	1894.JOER01000030_gene507	2.3e-207	729.6	Actinobacteria	uvrD2		3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GM2E@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2	NA|NA|NA	L	Belongs to the helicase family. UvrD subfamily
MAG.T12.45_01741	1996.JOFO01000065_gene1991	3.3e-94	352.8	Streptosporangiales	uvrD		3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJD0@201174,4EGHY@85012,COG0210@1,COG0210@2,COG2887@1,COG2887@2	NA|NA|NA	L	Belongs to the helicase family. UvrD subfamily
MAG.T12.45_01742	1298863.AUEP01000003_gene2841	1.4e-91	343.6	Propionibacteriales	fliD	GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02407	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IBVB@201174,4DP7F@85009,COG1345@1,COG1345@2	NA|NA|NA	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MAG.T12.45_01743	526225.Gobs_0983	7.6e-27	126.7	Frankiales	fliS	GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02422	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IRX7@201174,4ET7K@85013,COG1516@1,COG1516@2	NA|NA|NA	N	flagellar protein FliS
MAG.T12.45_01745	196162.Noca_0762	7.2e-27	126.7	Propionibacteriales	flgB			ko:K02387	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IQWB@201174,4DUZX@85009,COG1815@1,COG1815@2	NA|NA|NA	N	Flagella basal body rod protein
MAG.T12.45_01746	1298863.AUEP01000003_gene2837	4.8e-40	170.6	Propionibacteriales	flgC	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02388	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IKRZ@201174,4DR9V@85009,COG1558@1,COG1558@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T12.45_01747	196162.Noca_0760	1.2e-23	115.9	Propionibacteriales	fliE	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464		ko:K02408	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2GR0F@201174,4DSFF@85009,COG1677@1,COG1677@2	NA|NA|NA	NU	Flagellar hook-basal body complex protein FliE
MAG.T12.45_01748	1033730.CAHG01000006_gene1249	3.2e-135	488.8	Propionibacteriales	fliF			ko:K02409	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	2HG9F@201174,4DP5G@85009,COG1766@1,COG1766@2	NA|NA|NA	NU	Flagellar M-ring protein C-terminal
MAG.T12.45_01749	1283287.KB822581_gene1476	9.8e-117	426.8	Propionibacteriales	fliG	GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006935,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044403,GO:0044419,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588		ko:K02410	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Bacteria	2GP1H@201174,4DP5X@85009,COG1536@1,COG1536@2	NA|NA|NA	N	FliG N-terminal domain
MAG.T12.45_01750	196162.Noca_0757	1.2e-22	113.6	Propionibacteriales	fliH			ko:K02411,ko:K03223	ko02040,ko03070,map02040,map03070	M00332,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	2IRIT@201174,4DRP3@85009,COG1317@1,COG1317@2	NA|NA|NA	NU	Flagellar biosynthesis type III secretory pathway
MAG.T12.45_01751	397278.JOJN01000001_gene2897	2e-170	605.5	Propionibacteriales	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	2GKGV@201174,4DPDQ@85009,COG1157@1,COG1157@2	NA|NA|NA	NU	ATP synthase alpha/beta family, nucleotide-binding domain
MAG.T12.45_01752	935866.JAER01000042_gene2744	6.6e-14	84.0	Propionibacteriales													Bacteria	2B1ES@1,2GT2Q@201174,31TVG@2,4DSCJ@85009	NA|NA|NA	S	Flagellar FliJ protein
MAG.T12.45_01753	935866.JAER01000042_gene2745	5.6e-46	191.0	Propionibacteriales													Bacteria	2GIWB@201174,4DPT1@85009,COG0741@1,COG0741@2,COG0791@1,COG0791@2	NA|NA|NA	M	NlpC/P60 family
MAG.T12.45_01754	196162.Noca_0753	2.1e-19	103.6	Propionibacteriales	fliK			ko:K02414	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2GVZ8@201174,4DS9X@85009,COG3144@1,COG3144@2	NA|NA|NA	N	Flagellar hook-length control protein FliK
MAG.T12.45_01755	397278.JOJN01000001_gene2901	6.3e-30	137.1	Propionibacteriales	flgD			ko:K02389	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2IQIQ@201174,4DS0Z@85009,COG1843@1,COG1843@2	NA|NA|NA	N	Flagellar hook capping protein - N-terminal region
MAG.T12.45_01756	397278.JOJN01000001_gene2902	3.3e-110	404.8	Propionibacteriales	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02390	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	2I3KN@201174,4DNCD@85009,COG4786@1,COG4786@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T12.45_01757	196162.Noca_0750	1.4e-14	85.5	Propionibacteriales	flbD			ko:K02385					ko00000,ko02035				Bacteria	2GRTC@201174,4DVPB@85009,COG1582@1,COG1582@2	NA|NA|NA	N	Flagellar protein (FlbD)
MAG.T12.45_01758	1283287.KB822581_gene1417	3.4e-98	364.8	Propionibacteriales	motA			ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	2I92C@201174,4DP5S@85009,COG1291@1,COG1291@2	NA|NA|NA	N	MotA/TolQ/ExbB proton channel family
MAG.T12.45_01759	1298863.AUEP01000003_gene2824	2.4e-79	302.4	Propionibacteriales	motB			ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	2IG81@201174,4DTTH@85009,COG1360@1,COG1360@2	NA|NA|NA	N	Membrane MotB of proton-channel complex MotA/MotB
MAG.T12.45_01760	935866.JAER01000042_gene2752	8.2e-28	130.2	Propionibacteriales	fliL			ko:K02415					ko00000,ko02035				Bacteria	2ITFQ@201174,4DV67@85009,COG1580@1,COG1580@2	NA|NA|NA	N	Flagellar basal body-associated protein FliL
MAG.T12.45_01761	1283287.KB822581_gene1414	2.6e-87	328.9	Propionibacteriales	fliM			ko:K02416,ko:K02417	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	2ICP2@201174,4DNNZ@85009,COG1868@1,COG1868@2	NA|NA|NA	N	Flagellar motor switch protein FliM
MAG.T12.45_01762	196162.Noca_0745	2.4e-35	156.0	Propionibacteriales	fliN			ko:K02417	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	2IGHQ@201174,4DREH@85009,COG1886@1,COG1886@2	NA|NA|NA	NU	Type III flagellar switch regulator (C-ring) FliN C-term
MAG.T12.45_01764	408672.NBCG_01400	5.9e-71	275.0	Propionibacteriales			3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000		GH32		Bacteria	2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2	NA|NA|NA	G	Glycosyl hydrolases family 32
MAG.T12.45_01766	1449353.JQMQ01000004_gene6292	4.3e-81	308.5	Streptacidiphilus													Bacteria	2GIZ3@201174,2NKDE@228398,COG1814@1,COG1814@2	NA|NA|NA	S	VIT family
MAG.T12.45_01767	1210046.B277_10139	5.4e-175	620.5	Intrasporangiaceae	aat3		2.6.1.2,2.6.1.66	ko:K00814,ko:K14260	ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00171	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJ7R@201174,4FFAU@85021,COG0436@1,COG0436@2	NA|NA|NA	E	in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
MAG.T12.45_01768	446466.Cfla_1154	9e-227	793.1	Cellulomonadaceae	malL		3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13		Bacteria	2GKS4@201174,4F0T5@85016,COG0366@1,COG0366@2	NA|NA|NA	G	SMART alpha amylase catalytic sub domain
MAG.T12.45_01769	1121272.KB903290_gene4678	1.1e-96	360.1	Micromonosporales													Bacteria	2C1EG@1,2GK4W@201174,2Z7MZ@2,4DHRJ@85008	NA|NA|NA		
MAG.T12.45_01770	479432.Sros_0062	4.6e-70	271.9	Streptosporangiales	tetV												Bacteria	2GJPT@201174,4EJ0G@85012,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_01771	134676.ACPL_2692	7e-192	677.2	Micromonosporales													Bacteria	28HJF@1,2ICK7@201174,2Z7UK@2,4DAVB@85008	NA|NA|NA		
MAG.T12.45_01773	1386089.N865_05460	6.2e-56	223.4	Intrasporangiaceae				ko:K06996					ko00000				Bacteria	2IRUY@201174,4FGZX@85021,COG3324@1,COG3324@2	NA|NA|NA	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase
MAG.T12.45_01776	1195236.CTER_0960	1e-13	83.6	Firmicutes				ko:K01163					ko00000				Bacteria	1VBBR@1239,COG1670@1,COG1670@2	NA|NA|NA	J	Acetyltransferase (GNAT) domain
MAG.T12.45_01777	196162.Noca_1363	1.2e-29	136.0	Propionibacteriales													Bacteria	2IIQY@201174,4DR4W@85009,COG1917@1,COG1917@2	NA|NA|NA	S	Cupin 2, conserved barrel domain protein
MAG.T12.45_01778	593907.Celgi_0077	1.9e-103	382.1	Cellulomonadaceae	aspB												Bacteria	2GJ7R@201174,4F0IR@85016,COG0436@1,COG0436@2	NA|NA|NA	E	PFAM aminotransferase class I and II
MAG.T12.45_01779	754252.PFREUD_17710	9.4e-78	296.6	Actinobacteria													Bacteria	2I9IY@201174,COG0739@1,COG0739@2	NA|NA|NA	M	peptidase
MAG.T12.45_01783	1048339.KB913029_gene2897	2.2e-147	528.5	Frankiales	mcl1		4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63	ko:K01644,ko:K08691,ko:K14447,ko:K18292	ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934,R09292	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK5J@201174,4ESAE@85013,COG0697@1,COG0697@2,COG2301@1,COG2301@2	NA|NA|NA	G	Belongs to the HpcH HpaI aldolase family
MAG.T12.45_01784	1283283.ATXA01000005_gene2174	3.3e-68	265.4	Frankiales													Bacteria	2I198@201174,4ESMN@85013,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T12.45_01785	351607.Acel_1818	1.5e-108	399.8	Frankiales	mgtE												Bacteria	2GMMK@201174,4ERJN@85013,COG2239@1,COG2239@2	NA|NA|NA	P	CBS domain
MAG.T12.45_01786	253839.SSNG_04680	7.3e-52	210.3	Actinobacteria													Bacteria	2GJRV@201174,COG4420@1,COG4420@2	NA|NA|NA	S	membrane
MAG.T12.45_01787	743718.Isova_1998	4e-278	964.1	Promicromonosporaceae	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35		Bacteria	2GIVZ@201174,4F4ZX@85017,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MAG.T12.45_01788	1463856.JOHY01000039_gene1645	6.4e-138	497.3	Actinobacteria	mrp	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03593					ko00000,ko03029,ko03036				Bacteria	2GJUZ@201174,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MAG.T12.45_01789	269800.Tfu_0381	5e-08	64.7	Streptosporangiales	tatB	GO:0008150,GO:0040007		ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2IR0U@201174,4EKBD@85012,COG1826@1,COG1826@2	NA|NA|NA	U	mttA/Hcf106 family
MAG.T12.45_01790	1223523.H340_31413	1e-87	330.9	Actinobacteria			3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	2GJ96@201174,COG0265@1,COG0265@2	NA|NA|NA	O	Peptidase s1 and s6 chymotrypsin hap
MAG.T12.45_01791	1283287.KB822583_gene2793	1.3e-66	259.6	Propionibacteriales	safC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944											Bacteria	2GPEV@201174,4DNEI@85009,COG4122@1,COG4122@2	NA|NA|NA	S	O-methyltransferase
MAG.T12.45_01792	1394178.AWOO02000057_gene737	1e-98	367.5	Streptosporangiales			3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJRB@201174,4EFVT@85012,COG0260@1,COG0260@2	NA|NA|NA	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MAG.T12.45_01793	561175.KB894095_gene2192	4.3e-19	99.8	Streptosporangiales													Bacteria	2E39N@1,2GQFF@201174,32Y97@2,4EKN2@85012	NA|NA|NA	S	Protein of unknown function (DUF3117)
MAG.T12.45_01794	1380393.JHVP01000007_gene4322	6.6e-25	120.6	Frankiales													Bacteria	2II8Y@201174,4ETJ6@85013,COG3427@1,COG3427@2	NA|NA|NA	S	Polyketide cyclase / dehydrase and lipid transport
MAG.T12.45_01795	479433.Caci_7945	1.3e-07	62.4	Bacteria													Bacteria	COG3599@1,COG3599@2	NA|NA|NA	D	regulation of cell shape
MAG.T12.45_01796	1120933.ATUY01000009_gene1413	2.6e-123	448.7	Actinobacteria	malL		3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13		Bacteria	2GKS4@201174,4D32X@85005,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain protein
MAG.T12.45_01797	644283.Micau_3475	1.9e-27	129.4	Micromonosporales	ppaX		3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K16017	ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130		R01334,R06587	RC00017,RC00078	ko00000,ko00001,ko01000				Bacteria	2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2	NA|NA|NA	S	HAD-superfamily hydrolase, subfamily IA, variant 3
MAG.T12.45_01798	1043205.AFYF01000045_gene2925	1.6e-08	66.6	Intrasporangiaceae													Bacteria	2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021	NA|NA|NA	S	Protein of unknown function (DUF2975)
MAG.T12.45_01799	35754.JNYJ01000011_gene741	2.7e-22	110.9	Micromonosporales	yozG			ko:K07727					ko00000,ko03000				Bacteria	2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2	NA|NA|NA	K	Cro/C1-type HTH DNA-binding domain
MAG.T12.45_01800	35754.JNYJ01000086_gene2338	9.7e-22	109.4	Micromonosporales													Bacteria	2EH37@1,2GQTI@201174,33AV6@2,4DFMM@85008	NA|NA|NA		
MAG.T12.45_01803	471853.Bcav_3589	1.4e-38	166.8	Bacteria	MA20_05910			ko:K03668,ko:K09914					ko00000				Bacteria	COG3187@1,COG3187@2	NA|NA|NA	O	response to heat
MAG.T12.45_01804	290340.AAur_1158	9.7e-29	134.4	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IKVM@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_01805	1184609.KILIM_042_00240	8.8e-22	110.5	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IRNG@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_01806	526225.Gobs_1409	2.5e-45	189.1	Actinobacteria	apt		2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147				Bacteria	2IHB6@201174,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAG.T12.45_01808	1449347.JQLN01000007_gene1076	7.6e-138	497.3	Kitasatospora	ypeA			ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403			ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1			Bacteria	2GJ07@201174,2M4MQ@2063,COG0454@1,COG0456@2,COG0464@1,COG0464@2	NA|NA|NA	KO	ATPase family associated with various cellular activities (AAA)
MAG.T12.45_01809	397945.Aave_2022	3.3e-243	848.2	Comamonadaceae	treS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16	ko:K00700,ko:K05343,ko:K16146	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01557,R02108,R02110,R02112,R09945,R11262	RC00002,RC00078,RC01816	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	1MVKX@1224,2VHW5@28216,4ABG1@80864,COG0366@1,COG0366@2,COG3281@1,COG3281@2	NA|NA|NA	G	SMART alpha amylase catalytic sub domain
MAG.T12.45_01810	1121372.AULK01000001_gene1951	4.8e-98	364.4	Microbacteriaceae	uppP		3.6.1.27	ko:K06153	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Bacteria	2GJVG@201174,4FKPS@85023,COG1968@1,COG1968@2	NA|NA|NA	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MAG.T12.45_01811	543632.JOJL01000023_gene1726	3e-30	138.3	Micromonosporales													Bacteria	2IJFQ@201174,32SB1@2,4DE0Y@85008,COG1145@1	NA|NA|NA	C	Ferredoxin
MAG.T12.45_01812	710696.Intca_0817	1.7e-106	392.9	Intrasporangiaceae				ko:K04088		M00742			ko00000,ko00002,ko01000				Bacteria	2GJ8Q@201174,4FESN@85021,COG0053@1,COG0053@2	NA|NA|NA	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAG.T12.45_01813	543632.JOJL01000050_gene7408	3.5e-31	144.1	Micromonosporales				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	2H7QD@201174,4DJZF@85008,COG3170@1,COG3170@2,COG4733@1,COG4733@2	NA|NA|NA	NU	Fibronectin type III domain
MAG.T12.45_01814	1122611.KB903944_gene1165	2e-08	65.9	Streptosporangiales													Bacteria	2C5NN@1,2GV7Y@201174,2ZJPF@2,4EKGV@85012	NA|NA|NA		
MAG.T12.45_01815	935866.JAER01000009_gene774	4.1e-171	608.2	Propionibacteriales	fadD3		6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	2GIXQ@201174,4DPPW@85009,COG1022@1,COG1022@2	NA|NA|NA	I	AMP-binding enzyme
MAG.T12.45_01816	253839.SSNG_03609	7.6e-172	610.1	Actinobacteria	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GIWP@201174,COG0172@1,COG0172@2	NA|NA|NA	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MAG.T12.45_01817	266940.Krad_0255	1.3e-41	177.2	Actinobacteria													Bacteria	2GP42@201174,COG0561@1,COG0561@2	NA|NA|NA	J	hydrolase
MAG.T12.45_01818	172088.AUGA01000001_gene6522	8.4e-103	380.2	Bradyrhizobiaceae	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.5.1.54,4.2.1.51,5.4.99.5	ko:K03856,ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R00691,R01373,R01715,R01826	RC00360,RC00435,RC03116	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2667	Bacteria	1MU60@1224,2TSUT@28211,3JS53@41294,COG0077@1,COG0077@2	NA|NA|NA	E	Prephenate dehydratase
MAG.T12.45_01819	436229.JOEH01000009_gene4397	7.6e-81	307.4	Streptacidiphilus	glpQ		3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000				Bacteria	2GMMS@201174,2NI2R@228398,COG0584@1,COG0584@2	NA|NA|NA	C	Glycerophosphoryl diester phosphodiesterase family
MAG.T12.45_01820	1121928.AUHE01000001_gene1507	2.9e-76	292.7	Gordoniaceae	glcD2	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.2.4	ko:K00102	ko00620,map00620		R00197	RC00044	ko00000,ko00001,ko01000				Bacteria	2GKI9@201174,4GB5H@85026,COG0277@1,COG0277@2	NA|NA|NA	C	FAD linked oxidases, C-terminal domain
MAG.T12.45_01822	471852.Tcur_3420	2.8e-81	308.5	Streptosporangiales	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	2GJ1G@201174,4EGB1@85012,COG0336@1,COG0336@2	NA|NA|NA	J	Belongs to the RNA methyltransferase TrmD family
MAG.T12.45_01823	479433.Caci_1514	7.6e-38	163.7	Actinobacteria	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360		ko:K02860					ko00000,ko03009				Bacteria	2GK4I@201174,COG0806@1,COG0806@2	NA|NA|NA	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MAG.T12.45_01824	1274.HX89_09660	2e-21	108.2	Dermacoccaceae	CP_0960	GO:0008150,GO:0040007		ko:K06960					ko00000				Bacteria	1ZW6W@145357,2IQ4C@201174,COG1837@1,COG1837@2	NA|NA|NA	S	KH domain
MAG.T12.45_01825	561175.KB894094_gene1857	1.1e-45	189.5	Streptosporangiales	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02959	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	2IKU0@201174,4EJRE@85012,COG0228@1,COG0228@2	NA|NA|NA	J	Ribosomal protein S16
MAG.T12.45_01826	1464048.JNZS01000025_gene780	1.6e-118	433.0	Micromonosporales	ycaQ			ko:K09927					ko00000				Bacteria	2GJM7@201174,4DA91@85008,COG3214@1,COG3214@2	NA|NA|NA	S	Winged helix DNA-binding domain
MAG.T12.45_01827	446471.Xcel_1165	3.4e-185	654.8	Promicromonosporaceae	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9			Bacteria	2GK4R@201174,4F37P@85017,COG0541@1,COG0541@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MAG.T12.45_01828	1380356.JNIK01000018_gene821	6.5e-26	124.8	Frankiales													Bacteria	2ICMJ@201174,4ETKK@85013,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
MAG.T12.45_01832	1957.JODX01000002_gene4462	4.8e-46	191.8	Actinobacteria	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	2.7.1.33,6.3.4.15	ko:K01947,ko:K03524	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	2GN8Q@201174,COG0340@1,COG0340@2	NA|NA|NA	H	biotin lipoate A B protein ligase
MAG.T12.45_01833	500153.JOEK01000003_gene1233	4.5e-58	231.9	Actinobacteria	cya		4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN02@201174,COG2114@1,COG2114@2	NA|NA|NA	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase
MAG.T12.45_01834	1048339.KB913029_gene20	6.5e-39	167.2	Frankiales				ko:K07015					ko00000				Bacteria	2IFFV@201174,4ET34@85013,COG2246@1,COG2246@2	NA|NA|NA	S	PFAM GtrA family protein
MAG.T12.45_01835	1050202.KB913024_gene29	5.1e-151	540.8	Actinopolysporales	acdA	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1	ko:K00248,ko:K18244	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212		R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000				Bacteria	2GMEM@201174,407ZG@622450,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase, C-terminal domain
MAG.T12.45_01836	469383.Cwoe_5648	7.3e-58	231.1	Rubrobacteria			5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000				Bacteria	2HQKA@201174,4CS5Q@84995,COG2017@1,COG2017@2	NA|NA|NA	G	Aldose 1-epimerase
MAG.T12.45_01837	1048339.KB913029_gene1756	9.1e-37	160.6	Actinobacteria													Bacteria	28IGY@1,2H6U5@201174,2Z8I9@2	NA|NA|NA		
MAG.T12.45_01839	1304865.JAGF01000001_gene1598	1.2e-83	316.6	Actinobacteria	fnt			ko:K06212,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2			Bacteria	2I8DX@201174,COG2116@1,COG2116@2	NA|NA|NA	P	Formate nitrite transporter
MAG.T12.45_01840	591157.SSLG_04058	2.3e-20	104.0	Actinobacteria	rpmG			ko:K02913	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQFG@201174,COG0267@1,COG0267@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL33 family
MAG.T12.45_01842	1169154.KB897784_gene4300	2.2e-51	209.5	Actinobacteria													Bacteria	2GKX5@201174,COG0457@1,COG0457@2	NA|NA|NA	A	Belongs to the DEAD box helicase family
MAG.T12.45_01843	452652.KSE_57300	2.2e-79	302.8	Kitasatospora	yutF	GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120		R03024	RC00151	ko00000,ko00001,ko01000				Bacteria	2GK7V@201174,2M1NB@2063,COG0647@1,COG0647@2	NA|NA|NA	G	Haloacid dehalogenase-like hydrolase
MAG.T12.45_01844	351607.Acel_1135	6e-183	646.7	Frankiales	sufB			ko:K07033,ko:K09014					ko00000				Bacteria	2GKCZ@201174,4ERKY@85013,COG0719@1,COG0719@2	NA|NA|NA	O	TIGRFAM FeS assembly protein SufB
MAG.T12.45_01846	1944.JOAZ01000005_gene1991	4.5e-30	137.1	Streptomyces griseus group	hcaC			ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002				Bacteria	2IQK7@201174,41AUI@629295,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
MAG.T12.45_01847	1155714.KB891988_gene2109	2.6e-111	408.3	Actinobacteria	sufC			ko:K09013					ko00000,ko02000				Bacteria	2GKB7@201174,COG0396@1,COG0396@2	NA|NA|NA	O	FeS assembly ATPase SufC
MAG.T12.45_01848	471852.Tcur_2228	5e-163	580.9	Streptosporangiales	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000				Bacteria	2GIVK@201174,4EHYF@85012,COG0520@1,COG0520@2	NA|NA|NA	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MAG.T12.45_01849	471852.Tcur_2229	5.2e-51	207.2	Streptosporangiales	iscU			ko:K04488					ko00000				Bacteria	2IHY9@201174,4EIUC@85012,COG0822@1,COG0822@2	NA|NA|NA	C	NifU-like N terminal domain
MAG.T12.45_01850	1123320.KB889679_gene2403	1e-43	182.6	Actinobacteria	yitW			ko:K02612	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001				Bacteria	2IKUH@201174,COG2151@1,COG2151@2	NA|NA|NA	J	metal-sulfur cluster biosynthetic enzyme
MAG.T12.45_01851	222534.KB893671_gene3402	7.6e-44	183.7	Frankiales	merR2												Bacteria	2GM67@201174,4ESCD@85013,COG0789@1,COG0789@2	NA|NA|NA	K	SMART regulatory protein, MerR
MAG.T12.45_01852	85643.Tmz1t_2630	5.2e-44	183.7	Rhodocyclales	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	1NQH7@1224,2KWA5@206389,2VMXI@28216,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_01853	1122933.JNIY01000003_gene63	8e-48	196.8	Actinobacteria				ko:K21429					ko00000,ko01002				Bacteria	2GKWI@201174,COG4894@1,COG4894@2	NA|NA|NA	S	LURP-one-related
MAG.T12.45_01854	675635.Psed_4822	1.5e-88	333.6	Pseudonocardiales													Bacteria	2GM17@201174,4DYVE@85010,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_01855	269800.Tfu_0343	3.4e-72	278.1	Streptosporangiales													Bacteria	2GIZB@201174,4ENVQ@85012,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T12.45_01856	1246995.AFR_19415	6.2e-33	146.7	Micromonosporales				ko:K10947					ko00000,ko03000				Bacteria	2IQ51@201174,4DFEK@85008,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator PadR-like family
MAG.T12.45_01858	1035308.AQYY01000001_gene3456	1.1e-58	233.8	Clostridia													Bacteria	1UZ78@1239,24BM7@186801,COG3965@1,COG3965@2	NA|NA|NA	P	cation diffusion facilitator family transporter
MAG.T12.45_01859	1172188.KB911822_gene882	2.7e-145	522.3	Intrasporangiaceae				ko:K06158					ko00000,ko03012				Bacteria	2GK9S@201174,4FFDZ@85021,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
MAG.T12.45_01860	1265502.KB905943_gene2772	1.7e-266	925.2	Comamonadaceae	fadH		1.3.1.34	ko:K00219					ko00000,ko01000				Bacteria	1MVE0@1224,2VIW3@28216,4ABSX@80864,COG0446@1,COG0446@2,COG1902@1,COG1902@2	NA|NA|NA	C	NADH flavin oxidoreductase NADH oxidase
MAG.T12.45_01862	263358.VAB18032_19950	8.4e-92	343.6	Micromonosporales	estA			ko:K03930					ko00000,ko01000		CE1		Bacteria	2GJX4@201174,4D9HJ@85008,COG0627@1,COG0627@2	NA|NA|NA	S	Putative esterase
MAG.T12.45_01863	590998.Celf_1077	1.4e-56	226.5	Cellulomonadaceae				ko:K02081,ko:K03436					ko00000,ko03000				Bacteria	2GKWM@201174,4F32F@85016,COG1349@1,COG1349@2	NA|NA|NA	K	DeoR C terminal sensor domain
MAG.T12.45_01864	1151122.AQYD01000007_gene568	9.9e-65	253.4	Microbacteriaceae	phhB		3.5.4.33,4.2.1.96	ko:K01724,ko:K11991	ko00790,map00790		R04734,R10223	RC00477,RC01208	ko00000,ko00001,ko01000,ko03016,ko04147				Bacteria	2IHZE@201174,4FP56@85023,COG0596@1,COG0596@2,COG2154@1,COG2154@2	NA|NA|NA	H	Pterin 4 alpha carbinolamine dehydratase
MAG.T12.45_01865	56107.Cylst_0426	9.3e-44	185.3	Nostocales													Bacteria	1GQ7S@1117,1HRXM@1161,COG0823@1,COG0823@2,COG5276@1,COG5276@2	NA|NA|NA	Q	LVIVD repeat
MAG.T12.45_01866	2045.KR76_01175	1e-31	143.7	Propionibacteriales													Bacteria	2I8Y7@201174,4DU0I@85009,COG2197@1,COG2197@2	NA|NA|NA	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MAG.T12.45_01868	909613.UO65_1997	2.6e-65	255.0	Pseudonocardiales	ybhB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K06910					ko00000				Bacteria	2GMIG@201174,4DYXA@85010,COG1881@1,COG1881@2	NA|NA|NA	S	TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family
MAG.T12.45_01869	765910.MARPU_00780	1.7e-104	386.3	Chromatiales	gdh		1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100		R00248	RC00006,RC02799	ko00000,ko00001,ko01000				Bacteria	1NPPY@1224,1RRKZ@1236,1WWQA@135613,COG4198@1,COG4198@2	NA|NA|NA	S	Protein of unknown function (DUF1015)
MAG.T12.45_01870	1192034.CAP_2687	8.8e-61	240.7	Myxococcales			2.7.1.15,2.7.1.187,2.7.1.45	ko:K00852,ko:K00874,ko:K19978	ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200	M00061,M00308,M00631	R01051,R01541,R02750,R11184	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1RBE0@1224,2X9ZP@28221,2YVZZ@29,4386N@68525,COG0524@1,COG0524@2	NA|NA|NA	G	pfkB family carbohydrate kinase
MAG.T12.45_01871	397278.JOJN01000011_gene1599	2.5e-84	319.3	Propionibacteriales													Bacteria	2GJM3@201174,4DNDV@85009,COG1316@1,COG1316@2	NA|NA|NA	K	Cell envelope-related transcriptional attenuator domain
MAG.T12.45_01872	1313172.YM304_27660	3e-209	735.3	Bacteria													Bacteria	COG0433@1,COG0433@2	NA|NA|NA	S	helicase activity
MAG.T12.45_01873	1123023.JIAI01000002_gene4736	1.6e-163	582.4	Pseudonocardiales	rocD	GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iYO844.BSU40340	Bacteria	2GK0J@201174,4DZYH@85010,COG4992@1,COG4992@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T12.45_01874	367299.JOEE01000002_gene2367	4.8e-60	238.8	Intrasporangiaceae	dacB		3.4.16.4	ko:K07259	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	2GJPH@201174,4FGTP@85021,COG2027@1,COG2027@2	NA|NA|NA	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family
MAG.T12.45_01875	446471.Xcel_1105	2.1e-55	221.9	Promicromonosporaceae	rpiB		5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKJG@201174,4F4DS@85017,COG0698@1,COG0698@2	NA|NA|NA	G	Ribose/Galactose Isomerase
MAG.T12.45_01878	1120936.KB907213_gene4917	2.1e-32	144.8	Streptosporangiales	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2IKV7@201174,4EJPX@85012,COG0713@1,COG0713@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_01879	1194972.MVAC_02599	1.1e-65	256.9	Mycobacteriaceae	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	233A9@1762,2GKRS@201174,COG0839@1,COG0839@2	NA|NA|NA	C	Belongs to the complex I subunit 6 family
MAG.T12.45_01880	1504319.GM45_4160	3.5e-68	264.6	unclassified Actinobacteria (class)	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00337,ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iNJ661.Rv3153	Bacteria	2GJNU@201174,3UWSS@52018,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T12.45_01881	1123320.KB889574_gene5654	1.1e-123	449.9	Actinobacteria	nuoH		1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iNJ661.Rv3152	Bacteria	2GIVY@201174,COG1005@1,COG1005@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MAG.T12.45_01882	1306990.BARG01000058_gene6769	1.3e-11	74.7	Actinobacteria	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944		ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5			Bacteria	2GJ26@201174,COG0201@1,COG0201@2	NA|NA|NA	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MAG.T12.45_01883	1120941.AUBL01000002_gene2052	1.3e-59	236.1	Actinobacteria	adk		2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJ7T@201174,4D4SK@85005,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MAG.T12.45_01884	1120950.KB892746_gene3632	3.7e-79	301.6	Propionibacteriales	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	2GKKB@201174,4DNQ9@85009,COG0024@1,COG0024@2	NA|NA|NA	J	Methionine aminopeptidase
MAG.T12.45_01885	530564.Psta_3683	8.3e-134	483.8	Planctomycetes													Bacteria	2IX7A@203682,COG0464@1,COG0464@2	NA|NA|NA	O	growth
MAG.T12.45_01886	530564.Psta_3683	4.4e-135	488.0	Planctomycetes													Bacteria	2IX7A@203682,COG0464@1,COG0464@2	NA|NA|NA	O	growth
MAG.T12.45_01887	269800.Tfu_2622	1.2e-32	145.2	Streptosporangiales	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065		ko:K02518					ko00000,ko03012				Bacteria	2IQ4B@201174,4EK2Q@85012,COG0361@1,COG0361@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MAG.T12.45_01888	1284679.HMPREF1626_05675	1.4e-13	80.9	Actinobacteria	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02919	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GWMH@201174,4D6P0@85005,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
MAG.T12.45_01889	469371.Tbis_0590	1.1e-52	212.6	Pseudonocardiales	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02952	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHPN@201174,4E3FF@85010,COG0099@1,COG0099@2	NA|NA|NA	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MAG.T12.45_01890	1306174.JODP01000006_gene3594	3.9e-61	240.7	Actinobacteria	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02948	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFFC@201174,COG0100@1,COG0100@2	NA|NA|NA	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MAG.T12.45_01892	1128421.JAGA01000001_gene2274	2.3e-106	392.1	unclassified Bacteria	scrK		2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2NQJS@2323,COG1940@1,COG1940@2	NA|NA|NA	GK	ROK family
MAG.T12.45_01893	1032480.MLP_00540	3.1e-170	605.5	Propionibacteriales	hvsT			ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	2GJCB@201174,4DP1B@85009,COG0659@1,COG0659@2,COG4530@1,COG4530@2	NA|NA|NA	P	Sulfate permease family
MAG.T12.45_01894	1386089.N865_06805	1e-166	593.2	Intrasporangiaceae	ndh		1.6.99.3	ko:K03885	ko00190,map00190				ko00000,ko00001,ko01000				Bacteria	2GJFE@201174,4FENQ@85021,COG1252@1,COG1252@2	NA|NA|NA	C	NADH dehydrogenase
MAG.T12.45_01895	1323663.AROI01000026_gene1819	9.4e-75	288.5	Proteobacteria													Bacteria	1MU2C@1224,COG5001@1,COG5001@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T12.45_01896	1172188.KB911822_gene998	6e-58	231.1	Intrasporangiaceae				ko:K06996					ko00000				Bacteria	2GJFC@201174,4FGZF@85021,COG3324@1,COG3324@2	NA|NA|NA	S	glyoxalase bleomycin resistance protein dioxygenase
MAG.T12.45_01897	1380390.JIAT01000010_gene3784	3.5e-27	128.6	Actinobacteria			1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110		R03845,R06286	RC01008	ko00000,ko00001,ko01000				Bacteria	2I3A4@201174,COG4221@1,COG4221@2	NA|NA|NA	S	short chain dehydrogenase
MAG.T12.45_01898	1100721.ALKO01000016_gene1456	1.8e-86	326.2	Comamonadaceae													Bacteria	1MWDP@1224,2VHM1@28216,4ABW8@80864,COG3191@1,COG3191@2	NA|NA|NA	EQ	PFAM peptidase S58 DmpA
MAG.T12.45_01899	44251.PDUR_02765	6.7e-37	161.0	Paenibacillaceae				ko:K05772	ko02010,map02010	M00186			ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4			Bacteria	1UI3M@1239,27712@186822,4ISC5@91061,COG2998@1,COG2998@2	NA|NA|NA	H	Copper amine oxidase N-terminal domain
MAG.T12.45_01900	77635.BISU_0868	1.6e-50	206.1	Bacteria													Bacteria	COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_01901	1120942.AUBM01000007_gene585	1.2e-145	523.1	Actinobacteria	nplT												Bacteria	2GJUT@201174,4D48F@85005,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain protein
MAG.T12.45_01902	1120950.KB892759_gene6277	1e-66	261.5	Propionibacteriales													Bacteria	2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2	NA|NA|NA	D	PFAM Stage II sporulation D domain protein
MAG.T12.45_01903	1192034.CAP_8770	3.4e-24	117.9	Myxococcales													Bacteria	1NKMZ@1224,2WX3E@28221,2YXMJ@29,431JR@68525,COG5646@1,COG5646@2	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T12.45_01905	1035308.AQYY01000001_gene2967	4.1e-25	120.6	Firmicutes													Bacteria	1VCZF@1239,COG2329@1,COG2329@2	NA|NA|NA	S	Antibiotic biosynthesis monooxygenase
MAG.T12.45_01907	644283.Micau_3475	5.2e-25	121.3	Micromonosporales	ppaX		3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K16017	ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130		R01334,R06587	RC00017,RC00078	ko00000,ko00001,ko01000				Bacteria	2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2	NA|NA|NA	S	HAD-superfamily hydrolase, subfamily IA, variant 3
MAG.T12.45_01908	1304865.JAGF01000001_gene1621	1.8e-309	1068.1	Cellulomonadaceae	pfkA		2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019				Bacteria	2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2	NA|NA|NA	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MAG.T12.45_01909	1380354.JIAN01000005_gene1271	8.4e-175	620.9	Cellulomonadaceae			3.6.1.27	ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Bacteria	2GMAV@201174,4F0KN@85016,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
MAG.T12.45_01910	479431.Namu_0491	1.3e-30	139.0	Frankiales	lsrG		5.3.1.32	ko:K11530	ko02024,map02024				ko00000,ko00001,ko01000				Bacteria	2GSE1@201174,4EX0G@85013,COG1359@1,COG1359@2	NA|NA|NA	C	Antibiotic biosynthesis monooxygenase
MAG.T12.45_01911	479431.Namu_0492	1.8e-100	372.9	Actinobacteria	eutG		1.1.1.1,4.3.3.7	ko:K00001,ko:K01714	ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230	M00016,M00525,M00526,M00527	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000				Bacteria	2IDI8@201174,COG1454@1,COG1454@2	NA|NA|NA	C	Iron-containing alcohol dehydrogenase
MAG.T12.45_01912	1173264.KI913949_gene3844	8.9e-64	250.8	Oscillatoriales	panE		1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2643	Bacteria	1G2H9@1117,1H7Y1@1150,COG1893@1,COG1893@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MAG.T12.45_01913	28444.JODQ01000007_gene5583	1.1e-36	160.2	Streptosporangiales	chpE			ko:K06600,ko:K06895					ko00000,ko02000,ko02035	2.A.75.1,2.A.76			Bacteria	2INXA@201174,4EPSU@85012,COG1280@1,COG1280@2	NA|NA|NA	E	LysE type translocator
MAG.T12.45_01914	477641.MODMU_2141	5.8e-48	198.0	Frankiales	yybG												Bacteria	2GM3W@201174,4EUFF@85013,COG1357@1,COG1357@2	NA|NA|NA	S	Pentapeptide repeats (8 copies)
MAG.T12.45_01915	644283.Micau_2859	2.3e-188	665.2	Micromonosporales				ko:K01436					ko00000,ko01000,ko01002				Bacteria	2I2WA@201174,4DBB4@85008,COG1473@1,COG1473@2	NA|NA|NA	S	amidohydrolase
MAG.T12.45_01916	326424.FRAAL4415	9.9e-56	223.8	Actinobacteria													Bacteria	2GIV0@201174,COG0515@1,COG0515@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T12.45_01918	1121017.AUFG01000022_gene2176	2.2e-91	342.4	Intrasporangiaceae	fieF												Bacteria	2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2	NA|NA|NA	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAG.T12.45_01919	1123322.KB904635_gene2587	1e-110	406.8	Actinobacteria	drrA3			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GIY8@201174,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_01920	1463845.JOIG01000003_gene4753	3.3e-80	305.1	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GKJF@201174,COG0842@1,COG0842@2	NA|NA|NA	V	transport, permease protein
MAG.T12.45_01924	512565.AMIS_48700	3.4e-113	415.2	Micromonosporales	macB			ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	2GIRW@201174,4D8TU@85008,COG0577@1,COG0577@2	NA|NA|NA	V	MacB-like periplasmic core domain
MAG.T12.45_01925	1123320.KB889562_gene6766	9e-82	310.1	Actinobacteria				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GK3I@201174,COG1136@1,COG1136@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_01926	479432.Sros_8876	3.8e-29	136.3	Streptosporangiales	hlyD3			ko:K02005,ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Bacteria	2H154@201174,4EGKC@85012,COG0845@1,COG0845@2	NA|NA|NA	M	HlyD family secretion protein
MAG.T12.45_01927	512565.AMIS_33730	5.3e-09	67.0	Micromonosporales				ko:K00375					ko00000,ko03000				Bacteria	2GITW@201174,4D9DH@85008,COG1167@1,COG1167@2	NA|NA|NA	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MAG.T12.45_01928	1280688.AUJB01000008_gene544	4.5e-48	198.4	Pseudobutyrivibrio				ko:K02538					ko00000,ko03000				Bacteria	1TT5A@1239,24931@186801,3NGRF@46205,COG3711@1,COG3711@2	NA|NA|NA	K	CAT RNA binding domain
MAG.T12.45_01929	35754.JNYJ01000043_gene4398	8.7e-20	105.1	Micromonosporales													Bacteria	2GKG3@201174,4DDUZ@85008,COG2208@1,COG2208@2	NA|NA|NA	KT	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MAG.T12.45_01930	749414.SBI_08696	1.4e-69	269.6	Actinobacteria			3.2.1.10,3.2.1.20,3.2.1.93	ko:K01182,ko:K01187,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13,GH31		Bacteria	2GKS4@201174,COG0366@1,COG0366@2	NA|NA|NA	G	alpha amylase, catalytic
MAG.T12.45_01931	208444.JNYY01000016_gene805	2.1e-69	269.2	Pseudonocardiales													Bacteria	2GJBJ@201174,4E2I8@85010,COG1609@1,COG1609@2	NA|NA|NA	K	Bacterial regulatory proteins, lacI family
MAG.T12.45_01932	1081644.IMCC13023_04070	3e-46	192.2	Actinobacteria													Bacteria	2B8JV@1,2H60Z@201174,321V3@2	NA|NA|NA		
MAG.T12.45_01933	1081644.IMCC13023_04080	8.6e-196	690.3	Microbacteriaceae													Bacteria	2I7FH@201174,4FRRZ@85023,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T12.45_01935	1184607.AUCHE_08_00700	9.3e-60	236.9	Dermatophilaceae													Bacteria	2GKFS@201174,4F6SG@85018,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T12.45_01936	1184609.KILIM_012_00140	1.4e-28	132.9	Dermatophilaceae				ko:K02029,ko:K02030		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	2GN3G@201174,4F7CU@85018,COG0834@1,COG0834@2	NA|NA|NA	ET	Bacterial periplasmic substrate-binding proteins
MAG.T12.45_01937	28444.JODQ01000007_gene5740	1.7e-78	299.3	Streptosporangiales				ko:K02081,ko:K03436					ko00000,ko03000				Bacteria	2GKWM@201174,4EHNG@85012,COG1349@1,COG1349@2	NA|NA|NA	K	DeoR C terminal sensor domain
MAG.T12.45_01938	287986.DV20_35975	1.6e-75	289.7	Pseudonocardiales	fruK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703	Bacteria	2GK7E@201174,4E1A9@85010,COG1105@1,COG1105@2	NA|NA|NA	H	Belongs to the carbohydrate kinase PfkB family
MAG.T12.45_01939	1068978.AMETH_4863	6.2e-36	157.1	Pseudonocardiales	fruA		2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1			Bacteria	2IMPP@201174,4E3T9@85010,COG1762@1,COG1762@2	NA|NA|NA	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
MAG.T12.45_01940	446469.Sked_28590	1.7e-138	499.6	Actinobacteria	fruA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202,2.7.1.56	ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K11202	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R02071,R03232	RC00002,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1		iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796	Bacteria	2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2	NA|NA|NA	GT	Phosphotransferase System
MAG.T12.45_01944	110319.CF8_4272	1.1e-52	214.2	Actinobacteria	coiA			ko:K06198					ko00000				Bacteria	2IPIX@201174,COG4469@1,COG4469@2	NA|NA|NA	S	Competence protein
MAG.T12.45_01945	196162.Noca_1086	9e-147	527.3	Propionibacteriales	resA		3.1.21.5	ko:K01156					ko00000,ko01000,ko02048				Bacteria	2I8IG@201174,4DSXW@85009,COG1061@1,COG1061@2	NA|NA|NA	KL	Type III restriction enzyme, res subunit
MAG.T12.45_01946	1122175.ATXU01000003_gene740	4.8e-07	60.1	Microbacteriaceae	nrdE	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0016020,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0051063,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_3846,iYO844.BSU17380	Bacteria	2GKX9@201174,4FKB4@85023,COG0209@1,COG0209@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MAG.T12.45_01948	479433.Caci_0163	1.1e-183	649.8	Actinobacteria	atuC		2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4,6.4.1.5	ko:K01966,ko:K01969,ko:K13778,ko:K18472	ko00061,ko00280,ko00281,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00281,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00373,M00741	R00742,R01859,R03494,R04138,R04386	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIRU@201174,COG4799@1,COG4799@2	NA|NA|NA	I	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAG.T12.45_01950	479431.Namu_4967	3.2e-83	315.5	Frankiales	kch		3.6.1.22	ko:K03426,ko:K10716	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	2GKB8@201174,4ERFU@85013,COG1226@1,COG1226@2	NA|NA|NA	P	Ion channel
MAG.T12.45_01951	1313172.YM304_23820	4.2e-39	168.3	Actinobacteria				ko:K07117					ko00000				Bacteria	2GQAV@201174,COG2940@1,COG2940@2	NA|NA|NA	K	SET domain
MAG.T12.45_01955	590998.Celf_3040	3.5e-28	132.1	Bacteria													Bacteria	2EFAB@1,33939@2	NA|NA|NA		
MAG.T12.45_01956	590998.Celf_3045	6e-70	271.2	Bacteria			2.4.1.289	ko:K07011,ko:K16870					ko00000,ko01000,ko01003				Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T12.45_01957	1380354.JIAN01000008_gene3362	1.1e-31	143.7	Actinobacteria			3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020		R02886,R11308	RC00799	ko00000,ko00001,ko01000		GH6		Bacteria	2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2	NA|NA|NA	P	PFAM PKD domain containing protein
MAG.T12.45_01959	882083.SacmaDRAFT_4675	8.4e-54	217.2	Actinobacteria													Bacteria	2IAWJ@201174,COG2345@1,COG2345@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01960	1048339.KB913029_gene1673	1.3e-284	985.3	Frankiales	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	2GKGP@201174,4ES0Z@85013,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T12.45_01961	426716.JOAJ01000009_gene5889	2.4e-29	135.6	Nocardiaceae													Bacteria	2GNQ4@201174,4FUXM@85025,COG5512@1,COG5512@2	NA|NA|NA	S	Belongs to the UPF0232 family
MAG.T12.45_01962	436229.JOEH01000010_gene5297	1.6e-112	412.9	Streptacidiphilus	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K03629,ko:K07459	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	2GJCS@201174,2NGB8@228398,COG1195@1,COG1195@2	NA|NA|NA	L	AAA domain
MAG.T12.45_01963	1123322.KB904669_gene3635	1.4e-113	416.4	Actinobacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJK3@201174,COG0592@1,COG0592@2	NA|NA|NA	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MAG.T12.45_01964	1504319.GM45_1735	2.3e-21	107.5	unclassified Actinobacteria (class)	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837		ko:K02313	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Bacteria	2GJKI@201174,3UW7I@52018,COG0593@1,COG0593@2	NA|NA|NA	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MAG.T12.45_01965	1463820.JOGW01000006_gene6872	3.5e-11	73.2	Actinobacteria	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02914	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQFY@201174,COG0230@1,COG0230@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL34 family
MAG.T12.45_01966	888439.HMPREF9240_01622	6.9e-24	116.7	Actinobacteria	yidD			ko:K08998					ko00000				Bacteria	2GQZG@201174,4D6B8@85005,COG0759@1,COG0759@2	NA|NA|NA	S	Could be involved in insertion of integral membrane proteins into the membrane
MAG.T12.45_01967	1504319.GM45_6245	3e-88	332.0	unclassified Actinobacteria (class)	yidC			ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Bacteria	2GJBU@201174,3UWKK@52018,COG0706@1,COG0706@2	NA|NA|NA	U	60Kd inner membrane protein
MAG.T12.45_01968	1157637.KB892093_gene6652	7.8e-50	203.4	Actinobacteria	jag			ko:K06346,ko:K09749					ko00000				Bacteria	2GPZK@201174,COG1847@1,COG1847@2	NA|NA|NA	S	R3H domain protein
MAG.T12.45_01969	585531.HMPREF0063_10409	1.3e-50	206.5	Propionibacteriales	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501					ko00000,ko01000,ko03009,ko03036				Bacteria	2GM9Z@201174,4DQN8@85009,COG0357@1,COG0357@2	NA|NA|NA	M	Specifically methylates the N7 position of a guanine in 16S rRNA
MAG.T12.45_01970	1121385.AQXW01000004_gene2687	8.8e-89	333.6	Dermacoccaceae	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944		ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	1ZVBH@145357,2GNRN@201174,COG1475@1,COG1475@2	NA|NA|NA	K	Belongs to the ParB family
MAG.T12.45_01971	443218.AS9A_0015	1.1e-06	60.8	Actinobacteria													Bacteria	291QM@1,2H0PF@201174,2ZPAP@2	NA|NA|NA		
MAG.T12.45_01972	471852.Tcur_4976	8.6e-96	357.1	Streptosporangiales	ddl		6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2GRWM@201174,4EFUD@85012,COG1181@1,COG1181@2	NA|NA|NA	M	Belongs to the D-alanine--D-alanine ligase family
MAG.T12.45_01973	1454010.JEOE01000029_gene3028	5.9e-151	540.8	Cellulomonadaceae	avtA			ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210		R01939	RC00006	ko00000,ko00001,ko01000				Bacteria	2GITW@201174,4F2B4@85016,COG1167@1,COG1167@2	NA|NA|NA	EK	Aminotransferase class I and II
MAG.T12.45_01975	1032480.MLP_35050	8.1e-15	89.4	Propionibacteriales													Bacteria	2IBN6@201174,4DP5E@85009,COG1502@1,COG1502@2	NA|NA|NA	I	PLD-like domain
MAG.T12.45_01976	1048339.KB913029_gene1659	6.4e-90	337.8	Frankiales	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.17,3.5.1.28	ko:K01185,ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Bacteria	2GPA9@201174,4ERBQ@85013,COG0860@1,COG0860@2,COG3409@1,COG3409@2	NA|NA|NA	M	Cell wall hydrolase autolysin
MAG.T12.45_01977	67315.JOBD01000019_gene7672	2.1e-38	164.9	Actinobacteria	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko01000,ko03110				Bacteria	2IQ9T@201174,COG3118@1,COG3118@2	NA|NA|NA	O	belongs to the thioredoxin family
MAG.T12.45_01978	1184609.KILIM_019_00760	1.3e-128	466.1	Dermatophilaceae	trxB	GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K22345	ko00030,ko00450,map00030,map00450		R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000			iPC815.YPO1374	Bacteria	2GKD2@201174,4F6I4@85018,COG0492@1,COG0492@2	NA|NA|NA	O	Pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_01979	1120950.KB892740_gene2536	8.6e-55	221.5	Propionibacteriales													Bacteria	2GM4A@201174,4DN49@85009,COG0515@1,COG0515@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T12.45_01981	1120950.KB892740_gene2537	6.2e-108	398.3	Propionibacteriales	murJ			ko:K03980					ko00000,ko01011,ko02000	2.A.66.4			Bacteria	2GKN0@201174,4DNJI@85009,COG0728@1,COG0728@2	NA|NA|NA	KLT	MviN-like protein
MAG.T12.45_01982	1120950.KB892740_gene2538	1.8e-12	80.1	Propionibacteriales													Bacteria	2GN00@201174,4DQW4@85009,COG3170@1,COG3170@2	NA|NA|NA	NU	Tfp pilus assembly protein FimV
MAG.T12.45_01983	1120950.KB892708_gene4278	2.3e-93	349.4	Propionibacteriales	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	2GJRS@201174,4DPBJ@85009,COG0341@1,COG0341@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T12.45_01984	1504319.GM45_5165	3e-115	422.5	unclassified Actinobacteria (class)	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	2GJTT@201174,3UWKE@52018,COG0342@1,COG0342@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T12.45_01985	570268.ANBB01000054_gene4590	1.1e-139	503.1	Streptosporangiales	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJZF@201174,4EH70@85012,COG2255@1,COG2255@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MAG.T12.45_01986	1120950.KB892708_gene4274	1.4e-51	209.5	Propionibacteriales	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GN17@201174,4DQ7Y@85009,COG0632@1,COG0632@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MAG.T12.45_01987	471852.Tcur_2109	3.9e-51	208.0	Streptosporangiales	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJI5@201174,4EIKP@85012,COG0817@1,COG0817@2	NA|NA|NA	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MAG.T12.45_01988	557599.MKAN_09615	1.8e-93	350.1	Mycobacteriaceae													Bacteria	235TY@1762,2GKU0@201174,COG1020@1,COG1020@2	NA|NA|NA	Q	Diacylglycerol O-acyltransferase
MAG.T12.45_01989	269800.Tfu_2096	3.7e-110	404.4	Streptosporangiales	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	2GJ4G@201174,4EGE0@85012,COG0217@1,COG0217@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_01990	1463887.KL589984_gene3407	5.7e-69	267.3	Actinobacteria	pdxT	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750		R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000			iHN637.CLJU_RS19495	Bacteria	2GNYG@201174,COG0311@1,COG0311@2	NA|NA|NA	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MAG.T12.45_01991	644283.Micau_2259	1.8e-143	515.4	Micromonosporales	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750		R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000				Bacteria	2GK1T@201174,4DAJ6@85008,COG0214@1,COG0214@2	NA|NA|NA	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MAG.T12.45_01992	1120936.KB907223_gene2469	3.4e-58	232.3	Streptosporangiales	yerB												Bacteria	2GP8D@201174,4EGFU@85012,COG1470@1,COG1470@2	NA|NA|NA	S	Protein of unknown function (DUF3048) C-terminal domain
MAG.T12.45_01993	1157637.KB892156_gene4020	3.6e-38	164.9	Actinobacteria				ko:K03744					ko00000				Bacteria	2GK54@201174,COG1704@1,COG1704@2	NA|NA|NA	L	nUDIX hydrolase
MAG.T12.45_01994	73044.JNXP01000004_gene3166	5.1e-19	100.5	Actinobacteria	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256			R11702		ko00000,ko01000,ko01003		GT4		Bacteria	2GKQ8@201174,COG0438@1,COG0438@2	NA|NA|NA	M	PFAM Glycosyl transferase, group 1
MAG.T12.45_01995	1463881.KL591017_gene3237	5.2e-154	550.8	Actinobacteria	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K03798		M00742			ko00000,ko00002,ko01000,ko01002,ko03110				Bacteria	2GJ4Q@201174,COG0465@1,COG0465@2	NA|NA|NA	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAG.T12.45_01996	743718.Isova_2655	5.5e-83	313.9	Promicromonosporaceae	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000			iIT341.HP0928	Bacteria	2GP2P@201174,4F3XW@85017,COG0302@1,COG0302@2	NA|NA|NA	H	GTP cyclohydrolase I
MAG.T12.45_01997	590998.Celf_0561	4.2e-89	334.7	Cellulomonadaceae	folP		2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJDQ@201174,4F0TG@85016,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAG.T12.45_01998	1343740.M271_27135	4e-34	151.0	Actinobacteria	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000				Bacteria	2IHSW@201174,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MAG.T12.45_01999	1348663.KCH_43430	2e-35	155.6	Kitasatospora	folK		2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000				Bacteria	2H3G6@201174,2M2ED@2063,COG0801@1,COG0801@2	NA|NA|NA	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
MAG.T12.45_02000	1246995.AFR_41455	3.7e-13	81.6	Micromonosporales													Bacteria	2DRQG@1,2IFEG@201174,33CMQ@2,4DEJ0@85008	NA|NA|NA	S	Protein of unknown function (DUF3180)
MAG.T12.45_02001	1121926.AXWO01000013_gene2110	6.9e-07	60.1	Glycomycetales													Bacteria	2E8UC@1,2GRUC@201174,3334W@2,4EYXG@85014	NA|NA|NA		
MAG.T12.45_02002	479435.Kfla_6453	1.5e-23	115.5	Propionibacteriales	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333,ko:K05579,ko:K13378	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GKEZ@201174,4DSY9@85009,COG0649@1,COG0649@2	NA|NA|NA	C	Belongs to the complex I 49 kDa subunit family
MAG.T12.45_02003	1172188.KB911821_gene1742	4.3e-44	183.7	Intrasporangiaceae													Bacteria	2GIX8@201174,4FED0@85021,COG1960@1,COG1960@2	NA|NA|NA	I	acyl-CoA dehydrogenase
MAG.T12.45_02004	397278.JOJN01000006_gene1006	2.9e-50	206.1	Propionibacteriales			3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Bacteria	2HVQW@201174,4DQVN@85009,COG4427@1,COG4427@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2332)
MAG.T12.45_02005	1906.SFRA_14425	2.5e-18	98.6	Actinobacteria	prpE2												Bacteria	2GK8P@201174,COG0642@1,COG0642@2,COG2208@1,COG2208@2	NA|NA|NA	T	protein phosphatase 2C domain protein
MAG.T12.45_02006	1449346.JQMO01000003_gene3193	4.6e-43	181.8	Kitasatospora													Bacteria	2GKPK@201174,2M0AS@2063,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T12.45_02007	1048339.KB913029_gene2906	4.1e-99	367.9	Frankiales	soj			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2GNEQ@201174,4EUFG@85013,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T12.45_02008	1048339.KB913029_gene2907	3.7e-13	80.9	Frankiales													Bacteria	2C4RB@1,2HAZK@201174,2ZVRN@2,4EWZ7@85013	NA|NA|NA		
MAG.T12.45_02009	1155714.KB891987_gene2874	1.4e-169	602.8	Actinobacteria	deaD		3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GIUR@201174,COG0513@1,COG0513@2	NA|NA|NA	L	Belongs to the DEAD box helicase family
MAG.T12.45_02010	452652.KSE_48740	2.5e-60	238.8	Kitasatospora		GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0071771	1.16.3.1,4.1.99.5	ko:K03594,ko:K14331	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	2I2E1@201174,2M2BB@2063,COG1633@1,COG1633@2	NA|NA|NA	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like
MAG.T12.45_02011	477641.MODMU_4652	2.5e-14	84.3	Frankiales													Bacteria	2E3M2@1,2GQQW@201174,32YJA@2,4ETF4@85013	NA|NA|NA	S	Protein of unknown function (DUF3107)
MAG.T12.45_02012	227882.SAV_3094	7.2e-34	150.2	Actinobacteria													Bacteria	2GVM5@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_02013	298655.KI912266_gene2148	3.6e-186	657.5	Frankiales	ccr		1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200		R09738	RC00076	ko00000,ko00001,ko01000				Bacteria	2GKFF@201174,4ERWW@85013,COG0604@1,COG0604@2	NA|NA|NA	C	TIGRFAM crotonyl-CoA reductase
MAG.T12.45_02014	1123320.KB889669_gene3225	2.6e-56	226.9	Actinobacteria													Bacteria	2GKG1@201174,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T12.45_02015	479435.Kfla_1561	1.7e-69	269.2	Propionibacteriales	exoA												Bacteria	2GMWF@201174,4DQ16@85009,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family 21
MAG.T12.45_02016	1121405.dsmv_0684	1.5e-21	111.7	Proteobacteria													Bacteria	1NI9Y@1224,2EX2M@1,33QDR@2	NA|NA|NA		
MAG.T12.45_02017	713586.KB900536_gene1549	1.3e-268	932.2	Chromatiales	ilvD		4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1259	Bacteria	1MUTQ@1224,1RMP2@1236,1WW0Q@135613,COG0129@1,COG0129@2	NA|NA|NA	EG	Belongs to the IlvD Edd family
MAG.T12.45_02018	1304865.JAGF01000001_gene77	3.6e-60	238.4	Actinobacteria													Bacteria	2GTCV@201174,COG1595@1,COG1595@2	NA|NA|NA	K	Putative zinc-finger
MAG.T12.45_02020	1386089.N865_12705	4.4e-35	154.1	Intrasporangiaceae	crcB			ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Bacteria	2HGGD@201174,4FHJ1@85021,COG0239@1,COG0239@2	NA|NA|NA	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAG.T12.45_02021	1068978.AMETH_3074	3e-43	181.0	Pseudonocardiales				ko:K09137					ko00000				Bacteria	2IM7J@201174,4E77D@85010,COG1993@1,COG1993@2	NA|NA|NA	S	Uncharacterized ACR, COG1993
MAG.T12.45_02022	1120950.KB892768_gene5293	7.5e-29	133.7	Propionibacteriales	crcB2	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425		ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Bacteria	2IKM1@201174,4DSBC@85009,COG0239@1,COG0239@2	NA|NA|NA	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAG.T12.45_02023	1278308.KB907074_gene586	2.8e-38	165.2	Microbacteriaceae													Bacteria	2IHZ7@201174,4FNK0@85023,COG0262@1,COG0262@2	NA|NA|NA	H	RibD C-terminal domain
MAG.T12.45_02024	1246448.ANAZ01000044_gene1247	8.5e-82	310.1	Streptosporangiales													Bacteria	2GV75@201174,4EK64@85012,COG1309@1,COG1309@2	NA|NA|NA	K	Tetracyclin repressor, C-terminal all-alpha domain
MAG.T12.45_02025	1246448.ANAZ01000005_gene5141	1.4e-106	392.9	Streptosporangiales													Bacteria	2GIS3@201174,4EHU0@85012,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T12.45_02026	593907.Celgi_2506	1.1e-96	359.8	Actinobacteria													Bacteria	2GMD7@201174,COG1305@1,COG1305@2	NA|NA|NA	E	transglutaminase
MAG.T12.45_02027	85643.Tmz1t_2231	8.6e-178	629.8	Rhodocyclales	casC			ko:K19124					ko00000,ko02048				Bacteria	1MVNH@1224,2KYSV@206389,2VP5P@28216,COG1857@1,COG1857@2	NA|NA|NA	L	CT1975-like protein
MAG.T12.45_02028	1304865.JAGF01000001_gene3099	1.1e-64	254.2	Actinobacteria			1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	2GRTN@201174,COG0446@1,COG0446@2	NA|NA|NA	P	pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_02029	926550.CLDAP_11630	1.5e-26	126.7	Bacteria			3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	COG2452@1,COG2452@2,COG4936@1,COG4936@2	NA|NA|NA	KT	Sensory domain found in PocR
MAG.T12.45_02030	298654.FraEuI1c_4843	7.7e-177	627.1	Frankiales	gcs2												Bacteria	2GN0J@201174,4ES9X@85013,COG2308@1,COG2308@2	NA|NA|NA	S	Circularly permuted ATP-grasp type 2
MAG.T12.45_02031	397278.JOJN01000019_gene2352	8.8e-45	187.6	Propionibacteriales	MA20_32425												Bacteria	2GN0T@201174,4DP16@85009,COG2307@1,COG2307@2	NA|NA|NA	S	A predicted alpha-helical domain with a conserved ER motif.
MAG.T12.45_02032	1283283.ATXA01000013_gene3448	1.7e-66	259.6	Frankiales													Bacteria	2GN5D@201174,4ESH4@85013,COG1305@1,COG1305@2	NA|NA|NA	E	Bacterial transglutaminase-like N-terminal region
MAG.T12.45_02033	1229780.BN381_130301	6.6e-50	204.1	unclassified Actinobacteria (class)	plsC2												Bacteria	2IDC7@201174,3UXB2@52018,COG0204@1,COG0204@2	NA|NA|NA	I	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T12.45_02034	751945.Theos_1037	1.6e-170	605.9	Deinococcus-Thermus				ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8			Bacteria	1WJJV@1297,COG2223@1,COG2223@2	NA|NA|NA	P	Major Facilitator Superfamily
MAG.T12.45_02035	1123386.AUIW01000006_gene1638	2.4e-147	528.9	Deinococcus-Thermus	narK			ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8			Bacteria	1WJ7D@1297,COG2223@1,COG2223@2	NA|NA|NA	P	Major Facilitator Superfamily
MAG.T12.45_02036	390989.JOEG01000004_gene3799	4e-82	312.0	Micromonosporales	mog		2.10.1.1,2.8.1.12,4.6.1.17	ko:K03635,ko:K03637,ko:K03750	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395,R09735,R11372	RC02507,RC03425,RC03462	ko00000,ko00001,ko01000				Bacteria	2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2	NA|NA|NA	H	Probable molybdopterin binding domain
MAG.T12.45_02037	66373.JOFQ01000008_gene441	6.9e-42	177.9	Actinobacteria	mobA		2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100		R11581		ko00000,ko00001,ko01000				Bacteria	2GJVE@201174,COG0746@1,COG0746@2	NA|NA|NA	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MAG.T12.45_02038	1380393.JHVP01000002_gene1835	1.7e-44	185.7	Frankiales	moaC		4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Bacteria	2IHR6@201174,4ESM0@85013,COG0315@1,COG0315@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MAG.T12.45_02039	208444.JNYY01000006_gene6922	1e-67	263.8	Pseudonocardiales	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17	ko:K03635,ko:K03637,ko:K21147	ko00790,ko01100,ko04122,map00790,map01100,map04122		R07459,R07461,R09395,R11372	RC00043,RC02507,RC03425	ko00000,ko00001,ko01000				Bacteria	2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2	NA|NA|NA	H	TIGRFAM molybdenum cofactor synthesis
MAG.T12.45_02040	1120936.KB907219_gene3177	2.8e-117	428.7	Streptosporangiales	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000				Bacteria	2GN0V@201174,4EGC1@85012,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAG.T12.45_02041	1121952.ATXT01000015_gene350	3.3e-08	64.3	Microbacteriaceae	moaD		2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000				Bacteria	2HSWM@201174,4FQNM@85023,COG1977@1,COG1977@2	NA|NA|NA	H	ThiS family
MAG.T12.45_02042	478801.Ksed_19270	2e-81	309.7	Actinobacteria				ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	2H1V9@201174,COG0659@1,COG0659@2	NA|NA|NA	P	Molybdate transporter of MFS superfamily
MAG.T12.45_02045	298654.FraEuI1c_0532	6.9e-108	397.5	Actinobacteria	rbsC-2			ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	2GKMB@201174,COG1079@1,COG1079@2	NA|NA|NA	S	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_02046	298654.FraEuI1c_0533	6.7e-97	360.9	Frankiales				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	2GKAZ@201174,4EU1I@85013,COG4603@1,COG4603@2	NA|NA|NA	S	Belongs to the binding-protein-dependent transport system permease family
MAG.T12.45_02047	1123258.AQXZ01000014_gene4985	6.9e-167	594.0	Nocardiaceae	mglA		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	2H7KJ@201174,4G9EK@85025,COG3845@1,COG3845@2	NA|NA|NA	S	ATPases associated with a variety of cellular activities
MAG.T12.45_02048	326424.FRAAL6405	2.7e-71	275.4	Frankiales	ntaR												Bacteria	2IDZ6@201174,4ET86@85013,COG1802@1,COG1802@2	NA|NA|NA	K	FCD
MAG.T12.45_02049	479433.Caci_6448	2e-59	235.7	Actinobacteria													Bacteria	2F0VE@1,2INWW@201174,33TX8@2	NA|NA|NA		
MAG.T12.45_02050	446471.Xcel_0031	1.9e-111	409.5	Actinobacteria													Bacteria	2GWBV@201174,COG1672@1,COG1672@2	NA|NA|NA	S	AAA ATPase domain
MAG.T12.45_02051	1122599.AUGR01000005_gene1973	1.9e-126	459.5	Oceanospirillales													Bacteria	1MWUX@1224,1RQ8G@1236,1XK8Z@135619,COG0076@1,COG0076@2	NA|NA|NA	E	Glutamate decarboxylase and related PLP-dependent
MAG.T12.45_02052	479435.Kfla_0655	1.4e-35	155.6	Propionibacteriales													Bacteria	2IKXW@201174,4DR3R@85009,COG3824@1,COG3824@2	NA|NA|NA	S	Zincin-like metallopeptidase
MAG.T12.45_02053	1121272.KB903289_gene4351	1.8e-95	355.9	Actinobacteria													Bacteria	2IB3X@201174,COG5640@1,COG5640@2	NA|NA|NA	O	Trypsin-like serine protease
MAG.T12.45_02054	1211815.CBYP010000045_gene795	1.3e-78	300.4	Frankiales	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879		ko:K06048					ko00000,ko01000				Bacteria	2GKAA@201174,4ES1F@85013,COG2170@1,COG2170@2	NA|NA|NA	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MAG.T12.45_02055	1304865.JAGF01000001_gene1186	6.4e-155	555.1	Actinobacteria													Bacteria	2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_02056	1380356.JNIK01000013_gene4301	2.1e-50	204.9	Frankiales													Bacteria	2GR1G@201174,4EWZ9@85013,COG3631@1,COG3631@2	NA|NA|NA	S	SnoaL-like polyketide cyclase
MAG.T12.45_02057	1380370.JIBA01000006_gene3355	3.3e-83	314.7	Intrasporangiaceae				ko:K07118					ko00000				Bacteria	2GK2P@201174,4FH0H@85021,COG2910@1,COG2910@2	NA|NA|NA	S	NAD(P)H-binding
MAG.T12.45_02058	1380370.JIBA01000011_gene3042	3.5e-135	488.0	Intrasporangiaceae													Bacteria	299PK@1,2ICYR@201174,2ZWRX@2,4FEZK@85021	NA|NA|NA	S	Rifampin ADP-ribosyl transferase
MAG.T12.45_02059	1380393.JHVP01000015_gene4172	2.1e-58	231.9	Frankiales			3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100		R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000				Bacteria	2IFKS@201174,4EVNQ@85013,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MAG.T12.45_02060	1385520.N802_03220	2.4e-261	908.7	Intrasporangiaceae	vpr	GO:0005575,GO:0005576		ko:K14647	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GK3D@201174,4FE2Y@85021,COG1404@1,COG1404@2	NA|NA|NA	O	PA domain
MAG.T12.45_02061	357808.RoseRS_1515	4.2e-12	78.2	Chloroflexia													Bacteria	2DRD4@1,2G9Z1@200795,33B9X@2,377FH@32061	NA|NA|NA		
MAG.T12.45_02062	477641.MODMU_2166	6.6e-49	200.7	Frankiales													Bacteria	2IIBU@201174,308PC@2,4EV3D@85013,arCOG14808@1	NA|NA|NA	S	Domain of unknown function (DUF4956)
MAG.T12.45_02063	1869.MB27_41620	4.7e-48	198.4	Micromonosporales	ygiF	GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355	3.6.1.25	ko:K18446					ko00000,ko01000				Bacteria	2II2C@201174,4DCSN@85008,COG3025@1,COG3025@2	NA|NA|NA	S	VTC domain
MAG.T12.45_02064	1095767.CAHD01000028_gene1705	4.4e-64	252.7	Cellulomonadaceae													Bacteria	2GKIT@201174,2Z8AD@2,4F0EE@85016,arCOG08054@1	NA|NA|NA	S	Carbohydrate-binding domain-containing protein Cthe_2159
MAG.T12.45_02066	110319.CF8_3589	5.2e-66	258.8	Propionibacteriales													Bacteria	2ICM5@201174,4DQ8D@85009,COG4421@1,COG4421@2	NA|NA|NA	G	Protein of unknown function (DUF563)
MAG.T12.45_02067	479431.Namu_0418	1.9e-88	332.8	Frankiales													Bacteria	2GIS3@201174,4EU7J@85013,COG0604@1,COG0604@2	NA|NA|NA	C	alcohol dehydrogenase
MAG.T12.45_02068	1385519.N801_00245	1.2e-63	250.0	Intrasporangiaceae													Bacteria	2DBV7@1,2IGRZ@201174,2ZB9P@2,4FHPC@85021	NA|NA|NA	S	Domain of unknown function (DUF4386)
MAG.T12.45_02069	1304865.JAGF01000001_gene432	8e-18	96.3	Actinobacteria													Bacteria	2DBV7@1,2IGRZ@201174,2ZB9P@2	NA|NA|NA	S	Domain of unknown function (DUF4386)
MAG.T12.45_02070	1122609.AUGT01000013_gene4105	6.2e-243	847.4	Propionibacteriales				ko:K03556					ko00000,ko03000				Bacteria	2I50W@201174,4DPMG@85009,COG2909@1,COG2909@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_02071	479431.Namu_0429	1.3e-57	229.6	Frankiales			1.8.1.9	ko:K00384	ko00450,map00450		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000				Bacteria	2GIXN@201174,4ESGA@85013,COG0492@1,COG0492@2	NA|NA|NA	O	Pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_02072	1032480.MLP_34390	2.1e-44	185.3	Propionibacteriales	adk		2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2I45A@201174,4DSTH@85009,COG0563@1,COG0563@2	NA|NA|NA	F	AAA domain
MAG.T12.45_02074	1171373.PACID_21720	3.8e-27	127.5	Actinobacteria													Bacteria	2GXCS@201174,COG2361@1,COG2361@2	NA|NA|NA	S	Protein of unknown function DUF86
MAG.T12.45_02075	1035308.AQYY01000001_gene2076	1.3e-44	186.0	Bacteria				ko:K07075					ko00000				Bacteria	COG1669@1,COG1669@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T12.45_02077	1321778.HMPREF1982_01855	1e-59	237.3	Clostridia			2.7.1.15,2.7.1.187,2.7.1.45	ko:K00852,ko:K00874,ko:K19978	ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200	M00061,M00308,M00631	R01051,R01541,R02750,R11184	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1TRRQ@1239,24D41@186801,COG0524@1,COG0524@2	NA|NA|NA	G	pfkB family carbohydrate kinase
MAG.T12.45_02078	446470.Snas_3927	5.7e-19	101.3	Glycomycetales													Bacteria	2GQRD@201174,4EZTI@85014,COG1309@1,COG1309@2	NA|NA|NA	K	Tetracyclin repressor, C-terminal all-alpha domain
MAG.T12.45_02080	1386089.N865_05300	2.3e-24	119.4	Actinobacteria													Bacteria	2BFB8@1,2ISHF@201174,32949@2	NA|NA|NA		
MAG.T12.45_02082	471853.Bcav_3697	1e-70	273.9	Actinobacteria													Bacteria	2GIS3@201174,COG0604@1,COG0604@2	NA|NA|NA	C	alcohol dehydrogenase
MAG.T12.45_02083	1206737.BAGF01000151_gene6270	2.4e-72	279.3	Nocardiaceae													Bacteria	2GIS3@201174,4FYN0@85025,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T12.45_02084	710421.Mycch_0373	5.3e-167	594.3	Mycobacteriaceae			6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	235IH@1762,2GIXQ@201174,COG1022@1,COG1022@2	NA|NA|NA	I	synthetase
MAG.T12.45_02085	446471.Xcel_1049	1.1e-88	333.2	Promicromonosporaceae	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK7F@201174,4F46T@85017,COG0363@1,COG0363@2	NA|NA|NA	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MAG.T12.45_02086	526226.Gbro_2724	1.3e-82	313.2	Gordoniaceae	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K01990,ko:K01992,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2ICIF@201174,4GGY6@85026,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T12.45_02087	1454010.JEOE01000004_gene138	1.9e-83	315.8	Cellulomonadaceae	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K01990,ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2IH64@201174,4F2FJ@85016,COG1131@1,COG1131@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T12.45_02088	644548.SCNU_19462	8.7e-129	466.8	Gordoniaceae	ybhS			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJ7Y@201174,4GCQ2@85026,COG0842@1,COG0842@2	NA|NA|NA	U	ABC-2 family transporter protein
MAG.T12.45_02089	405948.SACE_6916	1.3e-28	133.7	Pseudonocardiales	menE		6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN9C@201174,4DYFK@85010,COG0318@1,COG0318@2	NA|NA|NA	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II
MAG.T12.45_02090	1239962.C943_03079	3.6e-117	427.6	Cytophagia													Bacteria	2BB8B@1,324R0@2,47RS3@768503,4NQG8@976	NA|NA|NA		
MAG.T12.45_02091	1123298.KB904079_gene537	1.3e-29	135.2	Bacilli	bglH		3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1		Bacteria	1TP19@1239,4HA1W@91061,COG2723@1,COG2723@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 1 family
MAG.T12.45_02092	1178540.BA70_17750	1.4e-49	203.4	Bacillus				ko:K02538,ko:K03488					ko00000,ko03000				Bacteria	1TQJJ@1239,1ZMHP@1386,4HBB3@91061,COG3711@1,COG3711@2	NA|NA|NA	K	CAT RNA binding domain
MAG.T12.45_02093	1122130.AUHN01000009_gene584	1.5e-139	503.4	Actinobacteria	bglF			ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271			ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6			Bacteria	2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	Pts system
MAG.T12.45_02094	998088.B565_0889	2.2e-26	125.6	Gammaproteobacteria													Bacteria	1RB8R@1224,1S1A6@1236,COG1051@1,COG1051@2	NA|NA|NA	F	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MAG.T12.45_02095	1500257.JQNM01000020_gene2569	1.5e-43	182.6	Rhizobiaceae													Bacteria	1N7IY@1224,2U993@28211,4BFSP@82115,COG3865@1,COG3865@2	NA|NA|NA	S	3-demethylubiquinone-9 3-methyltransferase
MAG.T12.45_02096	1504319.GM45_4930	8.5e-45	186.0	unclassified Actinobacteria (class)	sigA			ko:K03086					ko00000,ko03021				Bacteria	2GK3Z@201174,3UWCE@52018,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T12.45_02097	58123.JOFJ01000004_gene1829	1.5e-17	95.1	Streptosporangiales			2.7.1.193	ko:K02803	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7			Bacteria	2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2	NA|NA|NA	G	phosphotransferase system, EIIB
MAG.T12.45_02098	1961.JOAK01000019_gene6876	1e-113	417.2	Actinobacteria	nagE		2.7.1.193,2.7.1.199	ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	M00267,M00809	R02738,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9			Bacteria	2GKPM@201174,COG1263@1,COG1263@2	NA|NA|NA	G	Phosphotransferase System
MAG.T12.45_02099	1089545.KB913037_gene8298	6.2e-33	149.4	Pseudonocardiales				ko:K03556					ko00000,ko03000				Bacteria	2IBM2@201174,4E973@85010,COG2197@1,COG2197@2,COG2909@1,COG2909@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T12.45_02100	1246995.AFR_16520	1.5e-140	506.9	Micromonosporales			2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026		R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2		Bacteria	2GKFI@201174,4D8PJ@85008,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferases, probably involved in cell wall biogenesis
MAG.T12.45_02102	196162.Noca_2967	1.6e-27	129.0	Propionibacteriales													Bacteria	2IR3G@201174,4DRRV@85009,COG0589@1,COG0589@2	NA|NA|NA	T	Universal stress protein family
MAG.T12.45_02103	1306174.JODP01000013_gene7801	4.4e-215	753.8	Actinobacteria	metY		2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100		R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000			iNJ661.Rv3340	Bacteria	2I2EB@201174,COG2873@1,COG2873@2	NA|NA|NA	E	O-acetylhomoserine
MAG.T12.45_02104	1211815.CBYP010000071_gene1316	8.6e-23	114.8	Frankiales													Bacteria	2AR9G@1,2GN9V@201174,31GJC@2,4EWX7@85013	NA|NA|NA	S	Domain of unknown function (DUF4192)
MAG.T12.45_02105	398580.Dshi_3076	2.2e-09	68.9	Alphaproteobacteria	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Bacteria	1RCXW@1224,2U5JU@28211,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MAG.T12.45_02106	1112204.GPOL_c02910	2.3e-40	171.8	Gordoniaceae	yccF												Bacteria	2IKS5@201174,4GE90@85026,COG3304@1,COG3304@2	NA|NA|NA	S	Inner membrane component domain
MAG.T12.45_02107	595494.Tola_0290	2.2e-60	238.4	Gammaproteobacteria	rpiB		5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1604	Bacteria	1RHBF@1224,1SAUU@1236,COG0698@1,COG0698@2	NA|NA|NA	G	Ribose 5-phosphate isomerase
MAG.T12.45_02109	1121459.AQXE01000005_gene1544	4.8e-105	388.7	Desulfovibrionales													Bacteria	1RCM9@1224,2MHHP@213115,2WKHK@28221,42PGC@68525,COG4191@1,COG4191@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T12.45_02110	1049564.TevJSym_af00930	4.2e-79	302.0	unclassified Gammaproteobacteria	phcR			ko:K19622	ko02020,map02020				ko00000,ko00001,ko02022				Bacteria	1J6BK@118884,1RCW6@1224,1S3XV@1236,COG1639@1,COG1639@2,COG2204@1,COG2204@2	NA|NA|NA	T	HDOD domain
MAG.T12.45_02111	1122939.ATUD01000001_gene368	1.4e-74	287.0	Actinobacteria													Bacteria	2IKC2@201174,COG3437@1,COG3437@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T12.45_02112	1089544.KB912942_gene532	3.4e-177	627.9	Pseudonocardiales	nrdJ		1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2GKX9@201174,4DY0W@85010,COG0209@1,COG0209@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T12.45_02114	1179773.BN6_01060	2.4e-55	221.9	Pseudonocardiales	ftn		1.16.3.1,1.16.3.2	ko:K02217,ko:K22336	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	2IG5S@201174,4E2T6@85010,COG1528@1,COG1528@2	NA|NA|NA	P	Iron-storage protein
MAG.T12.45_02115	66897.DJ64_03950	1.6e-135	490.3	Actinobacteria	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJKA@201174,COG2812@1,COG2812@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MAG.T12.45_02116	749414.SBI_05309	1.2e-102	379.8	Actinobacteria	htpX			ko:K03799		M00743			ko00000,ko00002,ko01000,ko01002				Bacteria	2GMJF@201174,COG0501@1,COG0501@2	NA|NA|NA	O	Belongs to the peptidase M48B family
MAG.T12.45_02117	561175.KB894094_gene1456	8.1e-65	253.4	Streptosporangiales													Bacteria	2GP15@201174,31PZA@2,4EIMY@85012,arCOG04740@1	NA|NA|NA		
MAG.T12.45_02118	512565.AMIS_14080	5.9e-174	617.1	Micromonosporales	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM59@201174,4D97S@85008,COG0379@1,COG0379@2	NA|NA|NA	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MAG.T12.45_02119	1048339.KB913029_gene4641	9.2e-85	320.9	Frankiales	glxK	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000				Bacteria	2GKHX@201174,4ERQR@85013,COG1929@1,COG1929@2	NA|NA|NA	G	Belongs to the glycerate kinase type-1 family
MAG.T12.45_02120	1463855.JOHV01000002_gene2392	1e-49	202.6	Actinobacteria	erpA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564		ko:K13628,ko:K15724					ko00000,ko03016				Bacteria	2IHR0@201174,COG0316@1,COG0316@2	NA|NA|NA	S	Belongs to the HesB IscA family
MAG.T12.45_02121	1123320.KB889675_gene3934	3.1e-128	464.9	Actinobacteria	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100		R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000			iAF987.Gmet_2683	Bacteria	2GKBG@201174,COG0524@1,COG0524@2	NA|NA|NA	G	Ribokinase
MAG.T12.45_02122	367299.JOEE01000004_gene1430	9.1e-66	256.9	Intrasporangiaceae	aat		2.3.2.6	ko:K00684			R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000				Bacteria	2IFT7@201174,4FFYP@85021,COG2360@1,COG2360@2	NA|NA|NA	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MAG.T12.45_02123	1713.JOFV01000020_gene1360	9.1e-13	79.7	Cellulomonadaceae			2.8.1.7	ko:K04085,ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GSF4@201174,4F2Z8@85016,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
MAG.T12.45_02124	1394178.AWOO02000084_gene1172	1.8e-90	339.7	Streptosporangiales			2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GJ2B@201174,4EHSY@85012,COG1104@1,COG1104@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T12.45_02125	1504319.GM45_0705	5.6e-70	271.2	unclassified Actinobacteria (class)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6			Bacteria	2GNXA@201174,3UWMS@52018,COG1622@1,COG1622@2	NA|NA|NA	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MAG.T12.45_02126	67267.JNXT01000029_gene2800	3.8e-20	104.0	Actinobacteria													Bacteria	29W45@1,2GYN5@201174,30HP0@2	NA|NA|NA		
MAG.T12.45_02127	73044.JNXP01000003_gene4286	2.5e-14	85.1	Actinobacteria													Bacteria	2BI5H@1,2GRCS@201174,32CAS@2	NA|NA|NA		
MAG.T12.45_02128	465541.ATCJ01000005_gene2581	2.2e-27	128.6	Actinobacteria	nfeD			ko:K07340					ko00000				Bacteria	2IHZU@201174,COG1585@1,COG1585@2	NA|NA|NA	OU	Membrane protein implicated in regulation of membrane protease activity
MAG.T12.45_02129	1123251.ATWM01000010_gene2980	9.8e-89	333.6	Intrasporangiaceae	qmcA												Bacteria	2GJ1U@201174,4FFBS@85021,COG0330@1,COG0330@2	NA|NA|NA	O	prohibitin homologues
MAG.T12.45_02130	67352.JODS01000020_gene3992	7.1e-70	270.8	Actinobacteria	spoU2		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	2GJ12@201174,COG0566@1,COG0566@2	NA|NA|NA	J	rRNA methyltransferase
MAG.T12.45_02131	1033730.CAHG01000008_gene3077	4.5e-114	419.1	Actinobacteria			3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100		R01206,R02334	RC00467	ko00000,ko00001,ko01000		GH18		Bacteria	2IGIW@201174,COG3325@1,COG3325@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 18 family
MAG.T12.45_02132	1304865.JAGF01000001_gene2008	1.5e-199	703.0	Cellulomonadaceae	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ5U@201174,4F0GJ@85016,COG0280@1,COG0280@2,COG0857@1,COG0857@2	NA|NA|NA	C	belongs to the CobB CobQ family
MAG.T12.45_02133	446469.Sked_28510	6.5e-120	437.6	Actinobacteria	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1,2.7.2.15	ko:K00925,ko:K19697	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1034,iIT341.HP0903m,iNJ661.Rv0409	Bacteria	2GJAW@201174,COG0282@1,COG0282@2	NA|NA|NA	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MAG.T12.45_02135	1123024.AUII01000001_gene3046	2.2e-17	95.9	Pseudonocardiales	oatA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K19172					ko00000,ko02048				Bacteria	2GKI5@201174,4DZQE@85010,COG1835@1,COG1835@2,COG2755@1,COG2755@2	NA|NA|NA	I	Acyltransferase family
MAG.T12.45_02136	1172188.KB911821_gene2084	4.5e-48	198.0	Actinobacteria													Bacteria	29VND@1,2I845@201174,33797@2	NA|NA|NA		
MAG.T12.45_02138	68199.JNZO01000008_gene7675	2.2e-64	252.7	Bacteria													Bacteria	COG1073@1,COG1073@2	NA|NA|NA	S	thiolester hydrolase activity
MAG.T12.45_02139	479433.Caci_6918	5.6e-112	412.9	Actinobacteria													Bacteria	2GJN3@201174,COG2319@1,COG2319@2	NA|NA|NA	F	WD-40 repeat
MAG.T12.45_02140	33876.JNXY01000009_gene9258	2.1e-24	120.2	Micromonosporales	hstK		2.7.1.37,2.7.13.3	ko:K00870,ko:K10819,ko:K11527					ko00000,ko01000,ko01001,ko02022				Bacteria	2IBPU@201174,4DAU6@85008,COG0515@1,COG0515@2,COG2199@1,COG3706@2,COG3899@1,COG3899@2	NA|NA|NA	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.
MAG.T12.45_02141	994479.GL877878_gene2219	0.0	1274.2	Pseudonocardiales	uvrA2												Bacteria	2GJUV@201174,4DZ3D@85010,COG0178@1,COG0178@2	NA|NA|NA	L	Excinuclease ATPase subunit
MAG.T12.45_02142	1108045.GORHZ_055_00070	3.5e-58	231.9	Actinobacteria				ko:K07052					ko00000				Bacteria	2GREE@201174,COG1266@1,COG1266@2	NA|NA|NA	S	CAAX protease self-immunity
MAG.T12.45_02144	1137268.AZXF01000015_gene716	1.4e-63	249.2	Streptosporangiales													Bacteria	2GJGZ@201174,4EH75@85012,COG1051@1,COG1051@2	NA|NA|NA	F	Domain of unknown function (DUF4916)
MAG.T12.45_02145	105420.BBPO01000009_gene2256	7.9e-151	540.4	Streptacidiphilus													Bacteria	2GKKW@201174,2NHP9@228398,COG0624@1,COG0624@2	NA|NA|NA	E	Peptidase family M28
MAG.T12.45_02146	479433.Caci_4794	6.2e-94	350.9	Actinobacteria													Bacteria	2GMNA@201174,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T12.45_02147	1961.JOAK01000009_gene6352	2.4e-67	262.7	Actinobacteria	corA			ko:K03284					ko00000,ko02000	1.A.35.1,1.A.35.3			Bacteria	2GKNZ@201174,COG0598@1,COG0598@2	NA|NA|NA	P	Magnesium transport protein CorA
MAG.T12.45_02148	1463845.JOIG01000002_gene2537	2.3e-50	205.7	Actinobacteria			3.1.3.3,3.1.3.73,5.4.2.11	ko:K01834,ko:K02226,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	2GK8N@201174,COG0406@1,COG0406@2	NA|NA|NA	G	phosphoglycerate mutase
MAG.T12.45_02149	253839.SSNG_01507	5.7e-44	184.1	Actinobacteria													Bacteria	298YA@1,2GIYI@201174,2ZW25@2	NA|NA|NA	S	Protein of unknown function (DUF3090)
MAG.T12.45_02150	391037.Sare_2321	3.2e-59	235.3	Micromonosporales													Bacteria	2GME7@201174,4D9NY@85008,COG5032@1,COG5032@2	NA|NA|NA	BDLTU	Phosphatidylinositol
MAG.T12.45_02151	590998.Celf_1669	2.5e-38	165.6	Cellulomonadaceae	pabB		2.6.1.85,2.7.1.48,4.1.3.27	ko:K00876,ko:K01657,ko:K13950	ko00240,ko00400,ko00405,ko00790,ko00983,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00240,map00400,map00405,map00790,map00983,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R00985,R00986,R01548,R01549,R01716,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00010,RC00017,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2HQC8@201174,4F1E0@85016,COG0572@1,COG0572@2	NA|NA|NA	F	uridine kinase
MAG.T12.45_02152	1206737.BAGF01000150_gene6098	7.9e-227	793.9	Nocardiaceae			3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2			Bacteria	2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2	NA|NA|NA	P	PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein
MAG.T12.45_02154	1449355.JQNR01000005_gene4462	9.3e-34	151.0	Actinobacteria													Bacteria	2GNU5@201174,COG3305@1,COG3305@2	NA|NA|NA	S	Predicted membrane protein (DUF2127)
MAG.T12.45_02155	585530.HMPREF0183_0640	1.4e-24	119.4	Brevibacteriaceae													Bacteria	2HEXF@201174,4F9PJ@85019,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_02156	714083.JH370377_gene95	5.2e-119	433.7	Microbacteriaceae													Bacteria	2I8S4@201174,4FS6V@85023,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_02158	585530.HMPREF0183_0642	8.2e-219	766.1	Bacteria	tetA			ko:K08151,ko:K08153		M00668,M00717			ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8			Bacteria	COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_02160	585530.HMPREF0183_0645	0.0	1602.0	Brevibacteriaceae													Bacteria	2GJRK@201174,4F8SR@85019,COG0507@1,COG0507@2	NA|NA|NA	L	Pfam PF08751
MAG.T12.45_02162	102129.Lepto7375DRAFT_2915	1e-54	219.9	Oscillatoriales	apt		2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147				Bacteria	1G508@1117,1HAKH@1150,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAG.T12.45_02163	1043493.BBLU01000006_gene2218	1.3e-57	230.3	Actinobacteria													Bacteria	2I8IC@201174,COG2334@1,COG2334@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T12.45_02164	309800.C498_16184	4.8e-40	171.4	Halobacteria													Archaea	23WKG@183963,2XXWE@28890,arCOG13341@1,arCOG13341@2157	NA|NA|NA		
MAG.T12.45_02165	1504319.GM45_0280	4.1e-71	274.6	unclassified Actinobacteria (class)	yhhQ			ko:K09125					ko00000				Bacteria	2IFDB@201174,3UX0S@52018,COG1738@1,COG1738@2	NA|NA|NA	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MAG.T12.45_02166	479431.Namu_3445	4.5e-69	268.1	Actinobacteria			4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	2GW7W@201174,COG3001@1,COG3001@2	NA|NA|NA	G	Fructosamine kinase
MAG.T12.45_02167	1035308.AQYY01000001_gene3393	2.2e-160	572.0	Peptococcaceae	tgt		2.4.2.29	ko:K00773			R03789,R10209	RC00063	ko00000,ko01000,ko03016				Bacteria	1TNZ4@1239,247NJ@186801,260AS@186807,COG0343@1,COG0343@2	NA|NA|NA	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MAG.T12.45_02168	1121899.Q764_09130	2.4e-22	111.3	Flavobacterium													Bacteria	1I3HF@117743,2NX4C@237,4NSVZ@976,COG2314@1,COG2314@2	NA|NA|NA	S	Pfam TM2 domain
MAG.T12.45_02169	1385520.N802_03820	8.2e-53	213.8	Intrasporangiaceae				ko:K19519					ko00000,ko04516				Bacteria	2IHKV@201174,4FGQK@85021,COG2335@1,COG2335@2	NA|NA|NA	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.
MAG.T12.45_02170	590998.Celf_3363	5.3e-35	154.8	Cellulomonadaceae													Bacteria	2IM7X@201174,4F2HP@85016,COG5343@1,COG5343@2	NA|NA|NA	S	Anti-sigma-K factor rskA
MAG.T12.45_02171	590998.Celf_3362	4.2e-42	178.3	Cellulomonadaceae	litS			ko:K03088					ko00000,ko03021				Bacteria	2IKQ7@201174,4F2I1@85016,COG1595@1,COG1595@2	NA|NA|NA	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family
MAG.T12.45_02172	1003195.SCAT_1757	1.3e-226	793.1	Actinobacteria	pepN		3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJJ4@201174,COG0308@1,COG0308@2	NA|NA|NA	E	aminopeptidase N
MAG.T12.45_02173	28042.GU90_04140	1.3e-58	233.0	Pseudonocardiales				ko:K09019	ko00240,ko01100,map00240,map01100		R09289	RC00087	ko00000,ko00001,ko01000				Bacteria	2HC1J@201174,4DZB0@85010,COG0778@1,COG0778@2	NA|NA|NA	C	Nitroreductase family
MAG.T12.45_02174	35754.JNYJ01000005_gene5499	3.8e-09	68.9	Micromonosporales													Bacteria	2FIZ9@1,2INWA@201174,34AQ2@2,4DIXT@85008	NA|NA|NA		
MAG.T12.45_02175	710686.Mycsm_03220	1.4e-37	162.9	Mycobacteriaceae				ko:K07114					ko00000,ko02000	1.A.13.2.2,1.A.13.2.3			Bacteria	23EPF@1762,2HQ9A@201174,COG2304@1,COG2304@2	NA|NA|NA	S	von Willebrand factor type A domain
MAG.T12.45_02176	2002.JOEQ01000004_gene2898	1.4e-109	403.3	Streptosporangiales				ko:K07114					ko00000,ko02000	1.A.13.2.2,1.A.13.2.3			Bacteria	2GNSN@201174,4EH2B@85012,COG1840@1,COG1840@2,COG2304@1,COG2304@2	NA|NA|NA	P	von Willebrand factor type A domain
MAG.T12.45_02177	1229780.BN381_210036	1.3e-76	293.1	Actinobacteria													Bacteria	2GJSF@201174,COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T12.45_02178	1193181.BN10_1190010	4.9e-62	245.4	Intrasporangiaceae	pepA			ko:K08372	ko02020,map02020				ko00000,ko00001,ko01000,ko01002				Bacteria	2GJJ3@201174,4FJ5Z@85021,COG0265@1,COG0265@2	NA|NA|NA	O	Domain present in PSD-95, Dlg, and ZO-1/2.
MAG.T12.45_02179	1291050.JAGE01000001_gene2582	2e-68	266.2	Ruminococcaceae	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06023					ko00000,ko01000				Bacteria	1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2	NA|NA|NA	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MAG.T12.45_02180	1150399.AQYK01000001_gene1558	6.5e-43	181.0	Microbacteriaceae	iphP		3.1.3.48,3.1.4.53	ko:K01104,ko:K03651	ko00230,ko02025,map00230,map02025		R00191	RC00296	ko00000,ko00001,ko01000				Bacteria	2GK28@201174,4FN9A@85023,COG2365@1,COG2365@2	NA|NA|NA	T	Tyrosine phosphatase family
MAG.T12.45_02181	203119.Cthe_0110	6.1e-79	301.2	Ruminococcaceae	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06023					ko00000,ko01000				Bacteria	1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2	NA|NA|NA	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MAG.T12.45_02182	1246445.ANAY01000013_gene117	3.8e-38	165.6	Streptosporangiales	ykrP			ko:K13663					ko00000,ko01000				Bacteria	2GJXP@201174,4EHTM@85012,COG3594@1,COG3594@2	NA|NA|NA	G	Acyltransferase family
MAG.T12.45_02184	1048339.KB913029_gene479	1.9e-27	129.8	Actinobacteria													Bacteria	2F8QI@1,2H6TB@201174,3412U@2	NA|NA|NA		
MAG.T12.45_02185	1137268.AZXF01000033_gene3440	7.6e-26	124.4	Streptosporangiales													Bacteria	2I6YM@201174,4ER8Y@85012,COG1261@1,COG1261@2	NA|NA|NA	NO	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MAG.T12.45_02186	1449353.JQMQ01000005_gene5167	2.3e-25	122.9	Streptacidiphilus													Bacteria	2HT5K@201174,2NF4C@228398,COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T12.45_02187	1380354.JIAN01000009_gene3753	6.2e-133	480.7	Cellulomonadaceae				ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GKKJ@201174,4F10A@85016,COG4962@1,COG4962@2	NA|NA|NA	U	Type II/IV secretion system protein
MAG.T12.45_02188	1380354.JIAN01000009_gene3754	6.5e-50	204.5	Actinobacteria													Bacteria	2GN6E@201174,COG4965@1,COG4965@2	NA|NA|NA	U	type II secretion system
MAG.T12.45_02189	1380354.JIAN01000009_gene3755	1e-50	207.2	Actinobacteria				ko:K12510					ko00000,ko02044				Bacteria	2I2Z3@201174,COG4965@1,COG4965@2	NA|NA|NA	U	type II secretion system
MAG.T12.45_02191	1380354.JIAN01000009_gene3757	5.9e-19	100.5	Bacteria													Bacteria	COG4961@1,COG4961@2	NA|NA|NA	U	PFAM TadE family protein
MAG.T12.45_02192	1463853.JOHW01000040_gene6696	8.1e-22	110.2	Actinobacteria													Bacteria	2GRCJ@201174,COG4961@1,COG4961@2	NA|NA|NA	U	PFAM TadE family protein
MAG.T12.45_02193	1380354.JIAN01000009_gene3760	1.4e-75	291.6	Actinobacteria													Bacteria	2I8YV@201174,COG1652@1,COG1652@2	NA|NA|NA	NU	PFAM Peptidoglycan-binding LysM
MAG.T12.45_02194	1305732.JAGG01000001_gene778	3.5e-16	91.3	Microbacteriaceae	yidH			ko:K00389					ko00000				Bacteria	2GQU9@201174,4FQ80@85023,COG2149@1,COG2149@2	NA|NA|NA	S	Domain of unknown function (DUF202)
MAG.T12.45_02196	500153.JOEK01000001_gene4217	1.2e-184	652.9	Actinobacteria	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKG6@201174,COG0046@1,COG0046@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T12.45_02197	1120948.KB903217_gene1248	9.4e-48	196.8	Pseudonocardiales													Bacteria	2II0D@201174,4E47X@85010,COG4430@1,COG4430@2	NA|NA|NA	S	Bacteriocin-protection, YdeI or OmpD-Associated
MAG.T12.45_02198	1122602.ATXP01000017_gene2260	3.8e-26	124.4	Micrococcaceae													Bacteria	1W9SC@1268,2IQBF@201174,COG3255@1,COG3255@2	NA|NA|NA	I	Sterol carrier protein
MAG.T12.45_02199	479432.Sros_8991	1.9e-203	715.3	Streptosporangiales	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	2GK6I@201174,4EGDA@85012,COG0034@1,COG0034@2	NA|NA|NA	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MAG.T12.45_02200	1288083.AUKR01000017_gene2494	6.3e-130	470.7	Actinobacteria	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1844,iECSF_1327.ECSF_2340	Bacteria	2GJNY@201174,COG0150@1,COG0150@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine cyclo-ligase
MAG.T12.45_02201	1121272.KB903261_gene6014	2e-08	64.7	Micromonosporales													Bacteria	2EGRW@1,2IQF3@201174,33AI2@2,4DFQ7@85008	NA|NA|NA	S	Protein of unknown function (DUF3073)
MAG.T12.45_02202	479433.Caci_0301	2.8e-21	107.5	Actinobacteria	bldC												Bacteria	2GQJ9@201174,COG2452@1,COG2452@2	NA|NA|NA	L	TIGRFAM DNA binding domain protein, excisionase family
MAG.T12.45_02203	1440053.JOEI01000024_gene1194	2.4e-99	369.4	Actinobacteria	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03327					ko00000,ko02000	2.A.66.1			Bacteria	2GJE3@201174,COG0534@1,COG0534@2	NA|NA|NA	V	MATE efflux family protein
MAG.T12.45_02204	1033730.CAHG01000006_gene1155	6.4e-19	99.8	Propionibacteriales				ko:K07213	ko04978,map04978				ko00000,ko00001				Bacteria	2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2	NA|NA|NA	P	Heavy-metal-associated domain
MAG.T12.45_02205	1120949.KB903317_gene1657	2.1e-54	220.3	Micromonosporales				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T12.45_02206	208439.AJAP_30840	1.2e-28	134.4	Pseudonocardiales													Bacteria	2H2HE@201174,4E9WQ@85010,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_02207	1306174.JODP01000015_gene3952	1.7e-149	536.2	Actinobacteria													Bacteria	2IBIG@201174,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator superfamily
MAG.T12.45_02209	1449069.JMLO01000008_gene3545	5.9e-20	105.1	Nocardiaceae													Bacteria	2IAVM@201174,4G8K9@85025,COG0596@1,COG0596@2	NA|NA|NA	S	Alpha/beta hydrolase family
MAG.T12.45_02211	452652.KSE_38460	5.3e-98	364.0	Kitasatospora	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJY@201174,2M20R@2063,COG0047@1,COG0047@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T12.45_02212	653045.Strvi_0527	7e-21	106.7	Actinobacteria	purS		6.3.2.6,6.3.5.3	ko:K01923,ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463,R04591	RC00010,RC00064,RC00162,RC01160	ko00000,ko00001,ko00002,ko01000			iYO844.BSU06460	Bacteria	2GQV4@201174,COG1828@1,COG1828@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T12.45_02213	710685.MycrhN_3684	1.7e-33	149.4	Mycobacteriaceae													Bacteria	232CS@1762,28JRZ@1,2H9EF@201174,2Z9HI@2	NA|NA|NA	S	Domain of unknown function (DUF4126)
MAG.T12.45_02214	1120950.KB892759_gene6261	6.3e-67	261.2	Propionibacteriales	lytR2												Bacteria	2GJJJ@201174,4DPY2@85009,COG1316@1,COG1316@2	NA|NA|NA	K	Cell envelope-related transcriptional attenuator domain
MAG.T12.45_02216	471852.Tcur_2117	5.5e-42	178.7	Streptosporangiales													Bacteria	2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_02218	76636.JOEC01000002_gene2779	7.1e-15	85.9	Microbacteriaceae				ko:K09946					ko00000				Bacteria	2GQUP@201174,4FQ8G@85023,COG3422@1,COG3422@2	NA|NA|NA	S	Domain of unknown function (DUF1508)
MAG.T12.45_02219	1121272.KB903249_gene2195	4e-11	76.3	Micromonosporales													Bacteria	2B1IP@1,2GT98@201174,31TZW@2,4DG21@85008	NA|NA|NA	S	RDD family
MAG.T12.45_02220	397278.JOJN01000002_gene388	3e-19	101.3	Propionibacteriales	lsr												Bacteria	2C4MW@1,2IQ6A@201174,32RKK@2,4DRM6@85009	NA|NA|NA	S	Lsr2
MAG.T12.45_02221	1380354.JIAN01000008_gene3362	1.9e-29	136.7	Actinobacteria			3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020		R02886,R11308	RC00799	ko00000,ko00001,ko01000		GH6		Bacteria	2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2	NA|NA|NA	P	PFAM PKD domain containing protein
MAG.T12.45_02222	1043493.BBLU01000007_gene25	3.6e-191	674.5	Actinobacteria	ugp		2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2G3@201174,COG4284@1,COG4284@2	NA|NA|NA	G	UTP-glucose-1-phosphate uridylyltransferase
MAG.T12.45_02223	1454010.JEOE01000011_gene2396	7.7e-129	468.0	Actinobacteria													Bacteria	2IBWT@201174,COG4425@1,COG4425@2	NA|NA|NA	S	Alpha/beta-hydrolase family
MAG.T12.45_02224	1304865.JAGF01000001_gene735	2.9e-118	431.8	Cellulomonadaceae	ddhD												Bacteria	2GKW0@201174,4F0TD@85016,COG0673@1,COG0673@2	NA|NA|NA	S	PFAM oxidoreductase domain protein
MAG.T12.45_02225	1033730.CAHG01000016_gene637	5.8e-62	244.2	Propionibacteriales	dsbA												Bacteria	2GNBC@201174,4DQ7I@85009,COG2761@1,COG2761@2	NA|NA|NA	Q	DSBA-like thioredoxin domain
MAG.T12.45_02226	43354.JOIJ01000011_gene2664	2.9e-120	439.5	Pseudonocardiales													Bacteria	2GKI5@201174,4DYJ7@85010,COG1835@1,COG1835@2	NA|NA|NA	I	PFAM Acyltransferase
MAG.T12.45_02227	314345.SPV1_05173	2.2e-95	356.3	Proteobacteria													Bacteria	1NV1F@1224,COG2199@1,COG2199@2	NA|NA|NA	T	ggdef domain
MAG.T12.45_02228	33898.JRHJ01000076_gene172	2.3e-45	188.3	Actinobacteria				ko:K04750					ko00000				Bacteria	2IKY5@201174,COG2764@1,COG2764@2	NA|NA|NA	S	glyoxalase bleomycin resistance protein dioxygenase
MAG.T12.45_02229	404589.Anae109_0594	1.1e-63	250.4	Deltaproteobacteria	cyeA												Bacteria	1MZQM@1224,2WRK6@28221,42VPN@68525,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T12.45_02233	935866.JAER01000071_gene1360	1.2e-91	343.2	Propionibacteriales	fliA		2.7.11.1	ko:K02405,ko:K12132	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111				ko00000,ko00001,ko01000,ko01001,ko02035,ko03021				Bacteria	2GKBK@201174,4DP9I@85009,COG1191@1,COG1191@2	NA|NA|NA	K	RNA polymerase, sigma 28 subunit, SigD FliA WhiG
MAG.T12.45_02234	935866.JAER01000069_gene1411	5.7e-109	400.6	Propionibacteriales	fliC			ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134				ko00000,ko00001,ko02035				Bacteria	2GUKT@201174,4DP5T@85009,COG1344@1,COG1344@2	NA|NA|NA	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MAG.T12.45_02235	1045009.AFXQ01000015_gene2484	2.6e-70	271.9	Micrococcaceae	pdhA		1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1WAV4@1268,2IBRC@201174,COG1071@1,COG1071@2	NA|NA|NA	C	Dehydrogenase E1 component
MAG.T12.45_02236	1449044.JMLE01000025_gene3354	2.2e-134	485.3	Micrococcaceae	pdhA		1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1WAY5@1268,2GKFE@201174,COG0022@1,COG0022@2	NA|NA|NA	C	Transketolase, C-terminal domain
MAG.T12.45_02242	313589.JNB_00790	4.2e-60	238.4	Intrasporangiaceae				ko:K12511					ko00000,ko02044				Bacteria	2HZTC@201174,4FHX4@85021,COG2064@1,COG2064@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein F
MAG.T12.45_02243	1385519.N801_09660	6.5e-78	297.4	Intrasporangiaceae													Bacteria	2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2	NA|NA|NA	U	Type II secretion system (T2SS), protein F
MAG.T12.45_02244	110319.CF8_2946	2.3e-55	221.5	Propionibacteriales	ilvB		2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKU4@201174,4DNJX@85009,COG0028@1,COG0028@2	NA|NA|NA	E	Thiamine pyrophosphate enzyme, central domain
MAG.T12.45_02245	222534.KB893794_gene2458	1.4e-66	259.2	Frankiales	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ilvN,iJN678.ilvN	Bacteria	2GJCH@201174,4ESEU@85013,COG0440@1,COG0440@2	NA|NA|NA	E	Acetolactate synthase, small subunit
MAG.T12.45_02246	1385518.N798_04965	1.1e-57	231.1	Intrasporangiaceae	dac		3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	2GK3M@201174,4FFP2@85021,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
MAG.T12.45_02247	1463936.JOJI01000013_gene4702	3.9e-63	247.3	Actinobacteria	sdhB	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765	Bacteria	2GP9C@201174,COG0479@1,COG0479@2	NA|NA|NA	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein
MAG.T12.45_02248	351607.Acel_1320	2.6e-153	548.5	Frankiales	pilC			ko:K02653					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	2GQW0@201174,4ERP7@85013,COG1459@1,COG1459@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein F
MAG.T12.45_02249	590998.Celf_2006	1.3e-151	543.1	Actinobacteria	pilT			ko:K02669					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	2I9GT@201174,COG2805@1,COG2805@2	NA|NA|NA	NU	twitching motility protein
MAG.T12.45_02250	351607.Acel_1322	3.3e-223	781.2	Frankiales	pulE			ko:K02652					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	2I8C2@201174,4ES0V@85013,COG2804@1,COG2804@2	NA|NA|NA	NU	General secretory system II, protein E domain protein
MAG.T12.45_02251	861299.J421_3061	1.1e-08	68.6	Gemmatimonadetes													Bacteria	1ZSPN@142182,COG0457@1,COG0457@2	NA|NA|NA	S	Domain of unknown function (DUF4388)
MAG.T12.45_02252	1210045.ALNP01000016_gene1959	6e-64	251.1	Actinobacteria	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2552c	Bacteria	2GPQQ@201174,COG0169@1,COG0169@2	NA|NA|NA	E	Shikimate dehydrogenase
MAG.T12.45_02253	110319.CF8_1908	6.5e-74	284.6	Propionibacteriales	mltG			ko:K07082					ko00000				Bacteria	2GKGQ@201174,4DN3K@85009,COG1559@1,COG1559@2	NA|NA|NA	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MAG.T12.45_02254	28444.JODQ01000017_gene6586	2.9e-41	174.9	Streptosporangiales	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07447					ko00000,ko01000				Bacteria	2IQB0@201174,4EJ6B@85012,COG0816@1,COG0816@2	NA|NA|NA	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MAG.T12.45_02255	1048339.KB913029_gene3957	0.0	1090.5	Frankiales	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GIUG@201174,4ERRJ@85013,COG0013@1,COG0013@2	NA|NA|NA	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MAG.T12.45_02257	365528.KB891218_gene1492	1e-153	550.1	Frankiales	rarA			ko:K07478					ko00000				Bacteria	2GKDP@201174,4ERXK@85013,COG2256@1,COG2256@2	NA|NA|NA	L	AAA ATPase, central domain protein
MAG.T12.45_02258	1033730.CAHG01000016_gene542	1.8e-29	137.1	Propionibacteriales													Bacteria	28MY8@1,2GMYY@201174,2ZB54@2,4DNCX@85009	NA|NA|NA		
MAG.T12.45_02259	1029824.AFID01000005_gene713	6.9e-56	223.8	Micrococcaceae													Bacteria	1WB05@1268,2GJK7@201174,COG3464@1,COG3464@2	NA|NA|NA	L	4.5 Transposon and IS
MAG.T12.45_02260	1193181.BN10_1280004	1.7e-47	195.7	Intrasporangiaceae													Bacteria	2IFJT@201174,4FGZW@85021,COG3832@1,COG3832@2	NA|NA|NA	S	Polyketide cyclase / dehydrase and lipid transport
MAG.T12.45_02261	1386089.N865_20845	4.2e-21	106.7	Bacteria													Bacteria	2EM5W@1,33EV5@2	NA|NA|NA		
MAG.T12.45_02262	710696.Intca_0352	6.5e-50	203.4	Intrasporangiaceae				ko:K07341					ko00000,ko02048				Bacteria	2IR34@201174,4FHP3@85021,COG3654@1,COG3654@2	NA|NA|NA	S	Fic/DOC family
MAG.T12.45_02264	1380370.JIBA01000015_gene330	9e-26	122.9	Actinobacteria													Bacteria	2IRGU@201174,COG1846@1,COG1846@2	NA|NA|NA	K	transcriptional
MAG.T12.45_02266	710696.Intca_3499	6.1e-163	580.5	Intrasporangiaceae													Bacteria	2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
MAG.T12.45_02267	1184609.KILIM_074_00180	1.1e-21	108.6	Actinobacteria													Bacteria	2FF53@1,2H9GT@201174,34737@2	NA|NA|NA		
MAG.T12.45_02268	710696.Intca_3496	3.3e-50	204.1	Intrasporangiaceae				ko:K07171					ko00000,ko01000,ko02048				Bacteria	2HY4S@201174,4FJRX@85021,COG2337@1,COG2337@2	NA|NA|NA	L	PemK-like, MazF-like toxin of type II toxin-antitoxin system
MAG.T12.45_02270	1184609.KILIM_005_00630	4.1e-142	511.1	Actinobacteria	tniA			ko:K07497					ko00000				Bacteria	2IPDN@201174,COG2801@1,COG2801@2	NA|NA|NA	L	Mu transposase, C-terminal
MAG.T12.45_02271	1184609.KILIM_005_00620	5.6e-116	424.1	Bacteria	clpB			ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Bacteria	COG0542@1,COG0542@2	NA|NA|NA	O	response to heat
MAG.T12.45_02272	266264.Rmet_3008	9.3e-87	327.4	Burkholderiaceae	tniQ												Bacteria	1K4K9@119060,1PE75@1224,2C5W7@1,2VM9N@28216,2Z8WC@2	NA|NA|NA	S	TniQ
MAG.T12.45_02273	1454004.AW11_02902	1e-84	319.7	Betaproteobacteria	tniR												Bacteria	1MXXT@1224,2VJ32@28216,COG1961@1,COG1961@2	NA|NA|NA	L	Resolvase, N terminal domain
MAG.T12.45_02276	1449346.JQMO01000003_gene5623	1.1e-59	237.7	Kitasatospora			2.7.13.3	ko:K07778	ko02020,map02020	M00479			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2GKJJ@201174,2M2QI@2063,COG3463@1,COG3463@2	NA|NA|NA	S	Predicted membrane protein (DUF2079)
MAG.T12.45_02277	1035308.AQYY01000001_gene3431	1.1e-217	762.7	Peptococcaceae	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35		Bacteria	1TQAJ@1239,248E1@186801,260JM@186807,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MAG.T12.45_02278	479431.Namu_5218	2.8e-120	438.3	Frankiales	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679		ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	2GJTY@201174,4ERTY@85013,COG0443@1,COG0443@2	NA|NA|NA	O	Heat shock 70 kDa protein
MAG.T12.45_02279	351607.Acel_2116	9.4e-41	173.7	Frankiales	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065		ko:K02652,ko:K03687					ko00000,ko02035,ko02044,ko03029,ko03110	3.A.15.2			Bacteria	2GP4F@201174,4ESWP@85013,COG0576@1,COG0576@2	NA|NA|NA	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MAG.T12.45_02280	1122611.KB903952_gene6087	6.6e-109	401.0	Streptosporangiales	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679		ko:K03686,ko:K05516					ko00000,ko03029,ko03036,ko03110				Bacteria	2GJKK@201174,4EHSG@85012,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MAG.T12.45_02281	31964.CMS2809	6.6e-27	126.7	Microbacteriaceae	hspR			ko:K13640					ko00000,ko03000				Bacteria	2IQJ4@201174,4FP4F@85023,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T12.45_02282	436229.JOEH01000017_gene6930	0.0	1198.7	Streptacidiphilus	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944		ko:K03694,ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Bacteria	2GJ73@201174,2NGRH@228398,COG0542@1,COG0542@2	NA|NA|NA	O	C-terminal, D2-small domain, of ClpB protein
MAG.T12.45_02283	1896.JOAU01000009_gene6381	7.3e-47	193.4	Actinobacteria	osmC			ko:K04063					ko00000				Bacteria	2IFFB@201174,COG1764@1,COG1764@2	NA|NA|NA	O	PFAM OsmC family protein
MAG.T12.45_02285	66377.JOBH01000004_gene3779	6.5e-48	198.0	Actinobacteria													Bacteria	2A4ZY@1,2GMC5@201174,30TN1@2	NA|NA|NA		
MAG.T12.45_02286	187303.BN69_3335	1e-55	224.2	Alphaproteobacteria		GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704		ko:K07019					ko00000				Bacteria	1MWV1@1224,2TSMR@28211,COG0429@1,COG0429@2	NA|NA|NA	S	alpha/beta hydrolase fold
MAG.T12.45_02287	1123487.KB892846_gene459	1.8e-108	399.1	Proteobacteria	supH												Bacteria	1Q5HK@1224,COG0561@1,COG0561@2	NA|NA|NA	C	Hydrolase
MAG.T12.45_02288	105420.BBPO01000052_gene1853	1.2e-29	136.7	Streptacidiphilus													Bacteria	2H3AT@201174,2NGQ3@228398,COG3247@1,COG3247@2	NA|NA|NA	S	Short repeat of unknown function (DUF308)
MAG.T12.45_02289	223184.AS25_06030	8.4e-33	146.7	Micrococcaceae													Bacteria	1W9QW@1268,2IFHE@201174,COG5010@1,COG5010@2	NA|NA|NA	U	COG0457 FOG TPR repeat
MAG.T12.45_02290	110319.CF8_2787	2.4e-85	322.0	Propionibacteriales	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000			iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490	Bacteria	2GM2T@201174,4DNG2@85009,COG0289@1,COG0289@2	NA|NA|NA	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MAG.T12.45_02291	1123320.KB889675_gene4004	1.3e-142	513.1	Actinobacteria	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GJZ3@201174,COG0612@1,COG0612@2	NA|NA|NA	S	Belongs to the peptidase M16 family
MAG.T12.45_02292	566461.SSFG_02009	6.1e-170	603.6	Actinobacteria	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Bacteria	2GIT2@201174,COG1185@1,COG1185@2	NA|NA|NA	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MAG.T12.45_02293	1048339.KB913029_gene3748	1e-77	297.0	Frankiales	ypfJ	GO:0005575,GO:0005576		ko:K07054					ko00000				Bacteria	2H3UT@201174,4ES25@85013,COG2321@1,COG2321@2	NA|NA|NA	S	Putative neutral zinc metallopeptidase
MAG.T12.45_02294	479432.Sros_5972	1.1e-143	516.5	Streptosporangiales	ybiT												Bacteria	2GKQ4@201174,4EG0G@85012,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_02295	1504319.GM45_0330	1.7e-118	432.2	unclassified Actinobacteria (class)	glyQS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iSB619.SA_RS07880	Bacteria	2GIT3@201174,3UW9K@52018,COG0423@1,COG0423@2	NA|NA|NA	J	Catalyzes the attachment of glycine to tRNA(Gly)
MAG.T12.45_02297	1048339.KB913029_gene4777	9.7e-128	463.4	Frankiales	dus												Bacteria	2GJ8I@201174,4ERGB@85013,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MAG.T12.45_02298	1504822.CCNO01000011_gene176	5.1e-97	361.7	unclassified Bacteria	malS		3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13		Bacteria	2NPAG@2323,COG0366@1,COG0366@2	NA|NA|NA	G	PFAM Alpha amylase, catalytic
MAG.T12.45_02299	1160137.KB907307_gene3773	2.2e-160	572.4	Nocardiaceae	aglA		3.2.1.10,3.2.1.20,3.2.1.93	ko:K01182,ko:K01187,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13,GH31		Bacteria	2GKS4@201174,4FUMW@85025,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha-amylase domain
MAG.T12.45_02300	66377.JOBH01000001_gene1291	4.4e-250	870.9	Actinobacteria	ppdK		2.7.3.13,2.7.9.1	ko:K01006,ko:K22424	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK73@201174,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	G	Belongs to the PEP-utilizing enzyme family
MAG.T12.45_02301	110662.Syncc9605_1272	4.9e-11	73.9	Synechococcus													Bacteria	1GNNN@1117,1H18P@1129,2A4EJ@1,30T0D@2	NA|NA|NA		
MAG.T12.45_02302	1306174.JODP01000013_gene7557	1.7e-50	205.7	Actinobacteria	hit	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230		R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000				Bacteria	2GJT5@201174,COG0537@1,COG0537@2	NA|NA|NA	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MAG.T12.45_02303	1077972.ARGLB_080_00570	1.3e-07	64.7	Micrococcaceae													Bacteria	1W96H@1268,2GXWA@201174,COG4932@1,COG4932@2	NA|NA|NA	M	Belongs to the peptidase S8 family
MAG.T12.45_02304	1120949.KB903314_gene339	1.1e-150	539.7	Actinobacteria	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879		ko:K06048					ko00000,ko01000				Bacteria	2GKAA@201174,COG2170@1,COG2170@2	NA|NA|NA	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MAG.T12.45_02305	1122138.AQUZ01000001_gene1498	6.2e-277	959.9	Propionibacteriales	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GKTC@201174,4DN38@85009,COG0441@1,COG0441@2	NA|NA|NA	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAG.T12.45_02306	1108045.GORHZ_135_00210	1.1e-121	443.4	Gordoniaceae	acrA1_1												Bacteria	2I2PV@201174,4GAW1@85026,COG3320@1,COG3320@2	NA|NA|NA	M	Male sterility protein
MAG.T12.45_02307	196162.Noca_1668	8.8e-271	939.5	Actinobacteria		GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587	1.2.1.80	ko:K14330					ko00000,ko01000				Bacteria	2IEVX@201174,COG5322@1,COG5322@2	NA|NA|NA	S	oxidoreductase activity
MAG.T12.45_02308	1386089.N865_13575	9.6e-39	166.8	Intrasporangiaceae													Bacteria	2EH65@1,2I75W@201174,33AY1@2,4FH3V@85021	NA|NA|NA	S	Domain of unknown function (DUF1876)
MAG.T12.45_02311	471852.Tcur_2049	8.3e-23	114.0	Streptosporangiales													Bacteria	2EQY7@1,2I34U@201174,33IHV@2,4ER5N@85012	NA|NA|NA	S	Putative transmembrane protein (PGPGW)
MAG.T12.45_02312	67257.JODR01000017_gene4448	2.5e-26	125.2	Actinobacteria	ssgB	GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0007049,GO:0008150,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042244,GO:0042546,GO:0043934,GO:0043936,GO:0044085,GO:0044457,GO:0044464,GO:0045229,GO:0045787,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0071554,GO:0071555,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246											Bacteria	2IFE3@201174,32RFA@2,arCOG03175@1	NA|NA|NA	S	sporulation resulting in formation of a cellular spore
MAG.T12.45_02313	1003195.SCAT_5281	5.2e-71	274.6	Actinobacteria			2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GN5Z@201174,COG0115@1,COG0115@2	NA|NA|NA	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase
MAG.T12.45_02314	1172180.KB911785_gene337	2e-122	445.7	Actinobacteria	pabB		2.6.1.85,4.1.3.27,4.1.3.38	ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GN7D@201174,COG0147@1,COG0147@2	NA|NA|NA	EH	PFAM chorismate
MAG.T12.45_02316	1214101.BN159_1336	6.7e-07	61.2	Actinobacteria													Bacteria	2GTTI@201174,COG3976@1,COG3976@2	NA|NA|NA	S	FMN-binding domain protein
MAG.T12.45_02318	58123.JOFJ01000012_gene5428	2.4e-41	176.0	Streptosporangiales	apbE		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	2GN6F@201174,4EPRS@85012,COG1477@1,COG1477@2	NA|NA|NA	H	ApbE family
MAG.T12.45_02320	1283299.AUKG01000001_gene3534	1e-59	237.7	Rubrobacteria													Bacteria	2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2	NA|NA|NA	P	FAD-binding domain
MAG.T12.45_02322	1246995.AFR_11420	1.4e-36	159.8	Bacteria													Bacteria	2E1Q9@1,32X0K@2	NA|NA|NA		
MAG.T12.45_02324	436229.JOEH01000017_gene6907	1.3e-67	262.7	Streptacidiphilus			2.3.1.128	ko:K01163,ko:K03790					ko00000,ko01000,ko03009				Bacteria	2H4AD@201174,2NKG7@228398,COG1670@1,COG1670@2	NA|NA|NA	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAG.T12.45_02325	2045.KR76_20720	1.6e-35	155.6	Propionibacteriales													Bacteria	2IPEW@201174,4DS1Z@85009,COG1765@1,COG1765@2	NA|NA|NA	O	OsmC-like protein
MAG.T12.45_02327	285535.JOEY01000026_gene9022	1.6e-59	236.9	Actinobacteria													Bacteria	2GJEG@201174,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_02328	285535.JOEY01000026_gene9021	1.2e-59	236.5	Actinobacteria													Bacteria	2GJ46@201174,COG2197@1,COG2197@2	NA|NA|NA	T	response regulator
MAG.T12.45_02329	1385520.N802_06105	1.3e-61	243.0	Actinobacteria													Bacteria	2IFYE@201174,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_02330	1385520.N802_06110	2.7e-151	542.7	Actinobacteria	degS												Bacteria	2HDZV@201174,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_02331	1385520.N802_06100	6.2e-34	150.6	Actinobacteria													Bacteria	2E76N@1,2GRXJ@201174,338EF@2	NA|NA|NA		
MAG.T12.45_02332	1385520.N802_06095	1.5e-156	559.7	Actinobacteria													Bacteria	2GMJ4@201174,COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T12.45_02333	1027371.GOALK_026_00440	1.5e-57	229.6	Gordoniaceae													Bacteria	2I51D@201174,4GF97@85026,COG3945@1,COG3945@2	NA|NA|NA	S	Hemerythrin HHE cation binding domain
MAG.T12.45_02337	585529.HMPREF0291_11787	1.4e-24	119.8	Actinobacteria													Bacteria	2DN7X@1,2IQJG@201174,32W0S@2	NA|NA|NA		
MAG.T12.45_02338	710696.Intca_3511	8.7e-68	263.5	Intrasporangiaceae			3.6.1.55	ko:K03574					ko00000,ko01000,ko03400				Bacteria	2IJP8@201174,4FF1N@85021,COG4923@1,COG4923@2	NA|NA|NA	K	Protein of unknown function (DUF429)
MAG.T12.45_02339	446468.Ndas_4413	2.1e-152	545.4	Streptosporangiales			1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIX8@201174,4EHDP@85012,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase, middle domain
MAG.T12.45_02340	1380354.JIAN01000009_gene3741	8.3e-184	650.2	Actinobacteria	recD2_4												Bacteria	2GKJW@201174,COG1112@1,COG1112@2	NA|NA|NA	L	Superfamily I DNA and RNA helicases and helicase subunits
MAG.T12.45_02341	1504319.GM45_5885	1.5e-105	389.4	unclassified Actinobacteria (class)	leuS		6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJI1@201174,3UWBT@52018,COG0495@1,COG0495@2	NA|NA|NA	J	Leucyl-tRNA synthetase, Domain 2
MAG.T12.45_02342	1289387.AUKW01000018_gene2044	8.5e-63	247.3	Actinobacteria													Bacteria	2GIUV@201174,COG1307@1,COG1307@2	NA|NA|NA	S	DegV family
MAG.T12.45_02343	1386089.N865_01635	1.8e-35	156.0	Intrasporangiaceae	plsY		2.3.1.15	ko:K03977,ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko03009				Bacteria	2IF8Y@201174,4FG1E@85021,COG0344@1,COG0344@2	NA|NA|NA	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MAG.T12.45_02344	1122138.AQUZ01000017_gene6611	6e-28	131.3	Propionibacteriales	comEA			ko:K02237		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	2IQDC@201174,4DRFZ@85009,COG1555@1,COG1555@2	NA|NA|NA	L	Helix-hairpin-helix motif
MAG.T12.45_02347	67352.JODS01000014_gene5359	8.7e-206	723.0	Actinobacteria	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090		ko:K03701	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GJUV@201174,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MAG.T12.45_02350	1120950.KB892707_gene4731	9.6e-218	762.7	Propionibacteriales	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	2GJ2I@201174,4DNNP@85009,COG0174@1,COG0174@2	NA|NA|NA	E	glutamine synthetase
MAG.T12.45_02351	1048339.KB913029_gene4683	9.2e-221	773.1	Frankiales	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK2C@201174,4ESAT@85013,COG0171@1,COG0171@2,COG0388@1,COG0388@2	NA|NA|NA	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAG.T12.45_02352	1122137.AQXF01000003_gene2222	1.9e-35	156.4	Alphaproteobacteria	yokD		2.3.1.81	ko:K00662					ko00000,ko01000,ko01504				Bacteria	1R68C@1224,2U1PM@28211,COG2746@1,COG2746@2	NA|NA|NA	V	aminoglycoside
MAG.T12.45_02353	1380370.JIBA01000014_gene2048	2.9e-217	761.5	Intrasporangiaceae			1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120		R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000				Bacteria	2GJBM@201174,4FEPZ@85021,COG1250@1,COG1250@2	NA|NA|NA	I	Dehydrogenase
MAG.T12.45_02354	33876.JNXY01000008_gene8430	4.4e-74	284.6	Micromonosporales				ko:K07018					ko00000				Bacteria	2GP8G@201174,4DCBM@85008,COG2945@1,COG2945@2	NA|NA|NA	S	hydrolase of the alpha beta
MAG.T12.45_02355	446470.Snas_1605	5.5e-23	113.2	Glycomycetales													Bacteria	2E3EP@1,2GQST@201174,32YDP@2,4EZ3F@85014	NA|NA|NA	S	ATP- GTP-binding protein
MAG.T12.45_02356	1122138.AQUZ01000001_gene1540	4e-49	200.7	Propionibacteriales	ybiT												Bacteria	2GKQ4@201174,4DPPB@85009,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_02357	1463845.JOIG01000007_gene549	9e-12	75.9	Actinobacteria													Bacteria	2E4I7@1,2IQBB@201174,32ZDA@2	NA|NA|NA	S	transcriptional regulator
MAG.T12.45_02358	566461.SSFG_05534	2.9e-65	255.4	Actinobacteria	echA												Bacteria	2GKC4@201174,COG1024@1,COG1024@2	NA|NA|NA	I	Belongs to the enoyl-CoA hydratase isomerase family
MAG.T12.45_02359	1122138.AQUZ01000001_gene1538	3.2e-222	778.1	Propionibacteriales	msbA9			ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2GITR@201174,4DN7W@85009,COG1132@1,COG1132@2	NA|NA|NA	V	ABC transporter transmembrane region
MAG.T12.45_02360	1048339.KB913029_gene4318	9.5e-72	276.9	Frankiales													Bacteria	2GMEH@201174,4EUCD@85013,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T12.45_02361	28042.GU90_11695	1.8e-31	143.3	Pseudonocardiales													Bacteria	2GRSQ@201174,4DYIC@85010,COG4759@1,COG4759@2	NA|NA|NA	O	Sucrase/ferredoxin-like
MAG.T12.45_02362	446466.Cfla_1693	1.2e-284	985.7	Cellulomonadaceae	gyrA	GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464	5.99.1.3	ko:K02469,ko:K02621					ko00000,ko01000,ko02048,ko03032,ko03036,ko03400				Bacteria	2GJ2Q@201174,4F1NX@85016,COG0188@1,COG0188@2	NA|NA|NA	L	SMART DNA gyrase topoisomerase IV subunit A
MAG.T12.45_02363	1123320.KB889688_gene406	1.2e-276	958.7	Actinobacteria	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111	Bacteria	2GJ45@201174,COG1053@1,COG1053@2	NA|NA|NA	C	succinate dehydrogenase
MAG.T12.45_02364	105422.BBPM01000015_gene1944	1.2e-46	192.6	Streptacidiphilus	sdhD			ko:K00242,ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	2GNKE@201174,2NI1D@228398,COG2142@1,COG2142@2	NA|NA|NA	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit
MAG.T12.45_02365	1283283.ATXA01000007_gene3836	1.2e-14	85.1	Frankiales	sdhC			ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	2IKU7@201174,4EVCC@85013,COG2009@1,COG2009@2	NA|NA|NA	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit
MAG.T12.45_02367	405948.SACE_1498	7.8e-31	140.2	Pseudonocardiales	zur	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02076,ko:K03711,ko:K09823	ko02024,map02024				ko00000,ko00001,ko03000				Bacteria	2IKS3@201174,4E2M3@85010,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T12.45_02368	526225.Gobs_1602	3.8e-61	241.9	Frankiales	scbA			ko:K09815	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5			Bacteria	2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2	NA|NA|NA	P	Belongs to the bacterial solute-binding protein 9 family
MAG.T12.45_02369	1155718.KB891877_gene5380	1e-30	139.0	Actinobacteria													Bacteria	2GKDR@201174,COG0523@1,COG0523@2	NA|NA|NA	S	cobalamin synthesis CobW domain protein
MAG.T12.45_02370	1137271.AZUM01000002_gene3043	1.5e-175	623.2	Pseudonocardiales				ko:K06994					ko00000				Bacteria	2GIRQ@201174,4DZH4@85010,COG2409@1,COG2409@2	NA|NA|NA	S	RND superfamily
MAG.T12.45_02371	1304865.JAGF01000001_gene923	2.9e-119	434.9	Cellulomonadaceae	galE1		5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMCW@201174,4F0IT@85016,COG1087@1,COG1087@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family
MAG.T12.45_02372	1133850.SHJG_6974	2e-78	299.3	Actinobacteria	ceoB			ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2GK4N@201174,COG0569@1,COG0569@2	NA|NA|NA	P	PFAM TrkA-N domain protein
MAG.T12.45_02373	1122611.KB903954_gene5626	4.9e-82	310.8	Streptosporangiales	trkA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2GKB9@201174,4EGQI@85012,COG0569@1,COG0569@2	NA|NA|NA	P	TrkA-N domain
MAG.T12.45_02374	1120950.KB892748_gene3215	2e-46	192.6	Propionibacteriales													Bacteria	2AVV0@1,2GJKP@201174,31MNQ@2,4DQXN@85009	NA|NA|NA	S	Protein of unknown function (DUF3159)
MAG.T12.45_02375	1048339.KB913029_gene3870	5.3e-31	140.6	Frankiales			3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2IHRX@201174,4ETC1@85013,COG1200@1,COG1200@2	NA|NA|NA	KL	Nucleic acid binding, OB-fold, tRNA
MAG.T12.45_02376	593907.Celgi_1460	1.3e-49	203.4	Cellulomonadaceae													Bacteria	28J4D@1,2I2E9@201174,30NZ9@2,4F14W@85016	NA|NA|NA	S	Protein of unknown function (DUF3710)
MAG.T12.45_02377	1348663.KCH_54620	4.7e-60	237.3	Kitasatospora	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2IHYY@201174,2M2SY@2063,COG0756@1,COG0756@2	NA|NA|NA	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
MAG.T12.45_02378	68260.JOAY01000013_gene2772	2.3e-51	208.8	Actinobacteria													Bacteria	2GKY1@201174,COG2050@1,COG2050@2	NA|NA|NA	Q	PFAM thioesterase superfamily
MAG.T12.45_02379	935839.JAGJ01000003_gene1380	4.7e-18	97.8	Promicromonosporaceae													Bacteria	2E4C2@1,2IFS5@201174,32Z7M@2,4F4VX@85017	NA|NA|NA	S	Protein of unknown function (DUF3093)
MAG.T12.45_02381	1184609.KILIM_083_00160	3.4e-38	164.1	Dermatophilaceae													Bacteria	2ATJW@1,2IKN0@201174,31J3Z@2,4F70K@85018	NA|NA|NA	S	Domain of unknown function (DUF4193)
MAG.T12.45_02382	298654.FraEuI1c_2264	3.3e-41	174.9	Frankiales													Bacteria	2GP22@201174,4EVCG@85013,COG0663@1,COG0663@2	NA|NA|NA	S	Bacterial transferase hexapeptide (six repeats)
MAG.T12.45_02383	1348663.KCH_54540	2.2e-66	259.2	Kitasatospora	suhB		3.1.3.25,4.99.1.1,4.99.1.9	ko:K01092,ko:K01772	ko00521,ko00562,ko00860,ko01100,ko01110,ko04070,map00521,map00562,map00860,map01100,map01110,map04070	M00121,M00131	R00310,R01185,R01186,R01187,R11329	RC00078,RC01012	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJQE@201174,2M1IQ@2063,COG0483@1,COG0483@2	NA|NA|NA	G	Inositol monophosphatase family
MAG.T12.45_02384	68223.JNZY01000006_gene4113	2.9e-100	372.1	Actinobacteria	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJTQ@201174,COG0276@1,COG0276@2	NA|NA|NA	H	Catalyzes the ferrous insertion into protoporphyrin IX
MAG.T12.45_02385	590998.Celf_2152	3.5e-49	202.6	Cellulomonadaceae		GO:0008150,GO:0040007											Bacteria	28PUQ@1,2GNQM@201174,2ZCFK@2,4F1CN@85016	NA|NA|NA	S	Protein of unknown function (DUF3071)
MAG.T12.45_02386	477641.MODMU_3477	1.9e-73	283.1	Frankiales													Bacteria	2GISU@201174,4ESFM@85013,COG1524@1,COG1524@2	NA|NA|NA	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase
MAG.T12.45_02387	1120950.KB892748_gene3185	8.5e-54	216.9	Propionibacteriales													Bacteria	29850@1,2GKR1@201174,2ZVAX@2,4DQC6@85009	NA|NA|NA		
MAG.T12.45_02388	1123320.KB889707_gene7976	8e-235	820.5	Actinobacteria												iAF987.Gmet_2142	Bacteria	2GKN1@201174,COG0454@1,COG0456@2,COG1042@1,COG1042@2	NA|NA|NA	C	CoA-binding domain protein
MAG.T12.45_02389	1048339.KB913029_gene2786	3.1e-73	282.7	Frankiales	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759					ko00000,ko01000				Bacteria	2GJHB@201174,4ERGP@85013,COG0062@1,COG0062@2,COG0063@1,COG0063@2	NA|NA|NA	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MAG.T12.45_02390	1380346.JNIH01000003_gene2082	1.9e-118	432.6	Actinobacteria	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502		R00401	RC00285	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440	Bacteria	2GM2Y@201174,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAG.T12.45_02391	479432.Sros_1142	5.3e-82	311.6	Streptosporangiales													Bacteria	2GMCK@201174,4EFMQ@85012,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T12.45_02392	935839.JAGJ01000006_gene3358	5.9e-44	184.1	Promicromonosporaceae	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.1.221,5.1.1.1	ko:K01775,ko:K06925,ko:K07102	ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502		R00401,R08968,R11024	RC00002,RC00078,RC00285	ko00000,ko00001,ko01000,ko01011,ko03016				Bacteria	2IKV2@201174,4F4GX@85017,COG0802@1,COG0802@2	NA|NA|NA	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE
MAG.T12.45_02393	1449353.JQMQ01000005_gene3688	9.7e-46	190.3	Streptacidiphilus	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03016				Bacteria	2GMTM@201174,2NF90@228398,COG1214@1,COG1214@2	NA|NA|NA	O	Glycoprotease family
MAG.T12.45_02394	235985.BBPN01000023_gene2700	4.5e-27	127.9	Streptacidiphilus	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128,2.3.1.234	ko:K01409,ko:K03789,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03009,ko03016				Bacteria	2IM9R@201174,2NH04@228398,COG0454@1,COG0456@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
MAG.T12.45_02395	1184609.KILIM_003_00270	3.2e-152	544.7	Dermatophilaceae	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	2GJ98@201174,4F606@85018,COG0533@1,COG0533@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MAG.T12.45_02396	1169161.KB897730_gene1069	3.1e-12	80.9	Actinobacteria													Bacteria	2I8JH@201174,COG4585@1,COG4585@2	NA|NA|NA	T	signal transduction histidine kinase
MAG.T12.45_02397	1306174.JODP01000003_gene1895	7e-36	157.5	Actinobacteria													Bacteria	2I8Y7@201174,COG2197@1,COG2197@2	NA|NA|NA	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MAG.T12.45_02399	1157640.AQWO01000012_gene167	1.1e-67	264.2	Actinobacteria													Bacteria	2GK97@201174,COG2265@1,COG2265@2	NA|NA|NA	J	COG0500 SAM-dependent methyltransferases
MAG.T12.45_02400	1306174.JODP01000006_gene3620	6.1e-40	169.9	Actinobacteria	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077		ko:K04078					ko00000,ko03029,ko03110				Bacteria	2IKTH@201174,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MAG.T12.45_02402	1206730.BAGA01000093_gene452	1.1e-22	112.8	Nocardiaceae													Bacteria	2E7YB@1,2IRTP@201174,332CR@2,4G2XR@85025	NA|NA|NA		
MAG.T12.45_02403	33876.JNXY01000010_gene2613	9.7e-91	340.5	Micromonosporales	ssuA			ko:K02051		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17		iAF987.Gmet_0996	Bacteria	2GK7X@201174,4DBAN@85008,COG0715@1,COG0715@2	NA|NA|NA	P	ABC transporter, phosphonate, periplasmic substrate-binding protein
MAG.T12.45_02404	1146883.BLASA_1226	4.3e-114	417.9	Bacteria													Bacteria	COG0457@1,COG0457@2,COG3012@1,COG3012@2	NA|NA|NA	S	peptidyl-tyrosine sulfation
MAG.T12.45_02405	1151122.AQYD01000006_gene1984	3.7e-23	115.2	Bacteria			3.1.31.1	ko:K01174					ko00000,ko01000				Bacteria	COG1525@1,COG1525@2	NA|NA|NA	L	nuclease
MAG.T12.45_02410	1463879.JOHP01000007_gene550	2e-07	61.6	Actinobacteria													Bacteria	2CC1Y@1,2H69C@201174,3221K@2	NA|NA|NA	K	Transcription factor WhiB
MAG.T12.45_02412	1035308.AQYY01000001_gene2706	3.6e-28	132.5	Peptococcaceae													Bacteria	1UHSZ@1239,25H2T@186801,267I3@186807,COG2856@1,COG2856@2	NA|NA|NA	E	Zn peptidase
MAG.T12.45_02414	106370.Francci3_2360	1.6e-07	62.8	Actinobacteria													Bacteria	2E3KC@1,2GQQS@201174,32YIM@2	NA|NA|NA	S	Domain of unknown function (DUF4913)
MAG.T12.45_02415	1464048.JNZS01000015_gene3724	2.2e-140	506.1	Micromonosporales													Bacteria	2GNQ7@201174,4D94E@85008,COG3505@1,COG3505@2	NA|NA|NA	U	Type IV secretory pathway, VirD4 components
MAG.T12.45_02416	1394178.AWOO02000006_gene3482	1.3e-143	516.5	Streptosporangiales	traD			ko:K12071					ko00000,ko02044	3.A.7.11.1			Bacteria	2I70J@201174,4EN6Y@85012,COG0433@1,COG0433@2	NA|NA|NA	S	COG0433 Predicted ATPase
MAG.T12.45_02417	1394178.AWOO02000006_gene3481	1e-24	119.8	Streptosporangiales													Bacteria	28IPW@1,2HQJM@201174,2Z8PQ@2,4EN0Y@85012	NA|NA|NA		
MAG.T12.45_02418	469383.Cwoe_0911	9.9e-87	326.2	Actinobacteria	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GM3D@201174,COG0538@1,COG0538@2	NA|NA|NA	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family
MAG.T12.45_02419	367299.JOEE01000007_gene23	8.8e-73	280.4	Intrasporangiaceae	exoA		3.1.11.2	ko:K01142	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKIS@201174,4FEP7@85021,COG0708@1,COG0708@2	NA|NA|NA	L	exodeoxyribonuclease III
MAG.T12.45_02420	1122138.AQUZ01000084_gene8782	3.9e-126	458.4	Propionibacteriales	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	2GKN5@201174,4DPDV@85009,COG1253@1,COG1253@2	NA|NA|NA	S	Transporter associated domain
MAG.T12.45_02421	1150864.MILUP08_40848	6.8e-123	447.2	Micromonosporales	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJ9A@201174,4DAKB@85008,COG0180@1,COG0180@2	NA|NA|NA	J	Tryptophanyl-tRNA synthetase
MAG.T12.45_02422	266940.Krad_3968	1e-43	183.3	Actinobacteria													Bacteria	2GRF0@201174,COG1514@1,COG1514@2	NA|NA|NA	J	2'-5' RNA ligase
MAG.T12.45_02423	1157637.KB892155_gene7597	2.1e-72	279.3	Actinobacteria	speE		2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN8I@201174,COG0421@1,COG0421@2	NA|NA|NA	E	spermidine synthase
MAG.T12.45_02424	1101188.KI912155_gene948	1.3e-42	179.1	Micrococcaceae			1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110				Bacteria	1W9G6@1268,2IKP1@201174,COG0526@1,COG0526@2	NA|NA|NA	CO	Belongs to the thioredoxin family
MAG.T12.45_02425	1177594.MIC448_2030012	6.4e-17	95.5	Microbacteriaceae				ko:K13582	ko04112,map04112				ko00000,ko00001				Bacteria	2GPMH@201174,4FNHW@85023,COG3206@1,COG3206@2	NA|NA|NA	M	Domain of unknown function (DUF4349)
MAG.T12.45_02426	1306174.JODP01000029_gene3831	3.3e-30	138.7	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IK5Q@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_02427	471853.Bcav_2801	7.7e-294	1016.1	Actinobacteria	nasC			ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000				Bacteria	2HC9H@201174,COG3383@1,COG3383@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MAG.T12.45_02428	590998.Celf_1257	1.1e-171	609.8	Cellulomonadaceae	narU			ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iNJ661.Rv0267	Bacteria	2GJ1I@201174,4F0H3@85016,COG2223@1,COG2223@2	NA|NA|NA	P	PFAM major facilitator superfamily MFS_1
MAG.T12.45_02429	390989.JOEG01000004_gene3799	1.9e-84	319.7	Micromonosporales	mog		2.10.1.1,2.8.1.12,4.6.1.17	ko:K03635,ko:K03637,ko:K03750	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395,R09735,R11372	RC02507,RC03425,RC03462	ko00000,ko00001,ko01000				Bacteria	2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2	NA|NA|NA	H	Probable molybdopterin binding domain
MAG.T12.45_02430	465541.ATCJ01000005_gene4299	1.7e-44	186.4	Actinobacteria	mobA		2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100		R11581		ko00000,ko00001,ko01000				Bacteria	2GJVE@201174,COG0746@1,COG0746@2	NA|NA|NA	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MAG.T12.45_02431	1121946.AUAX01000006_gene3402	1.9e-43	182.2	Micromonosporales	moaC		4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Bacteria	2IHR6@201174,4DDCJ@85008,COG0315@1,COG0315@2,COG0521@1,COG0521@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MAG.T12.45_02432	1120934.KB894410_gene6919	1.3e-67	263.5	Pseudonocardiales	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17	ko:K03635,ko:K03637,ko:K21147	ko00790,ko01100,ko04122,map00790,map01100,map04122		R07459,R07461,R09395,R11372	RC00043,RC02507,RC03425	ko00000,ko00001,ko01000				Bacteria	2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2	NA|NA|NA	H	TIGRFAM molybdenum cofactor synthesis
MAG.T12.45_02434	1120950.KB892752_gene6143	6.6e-62	243.8	Propionibacteriales	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Bacteria	2GKCV@201174,4DPFB@85009,COG0193@1,COG0193@2	NA|NA|NA	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MAG.T12.45_02435	446466.Cfla_0883	6.2e-22	110.9	Cellulomonadaceae	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02897	ko03010,map03010	M00178			ko00000,ko00001,ko00002,ko03011				Bacteria	2GJPJ@201174,4F160@85016,COG1825@1,COG1825@2	NA|NA|NA	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MAG.T12.45_02436	1227487.C474_12461	1.7e-165	589.7	Halobacteria	treZ		2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Archaea	23ZEB@183963,2Y0XG@28890,COG0296@1,arCOG02951@2157	NA|NA|NA	G	Alpha amylase, catalytic domain
MAG.T12.45_02437	1504319.GM45_3005	2.9e-131	474.9	unclassified Actinobacteria (class)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ9S@201174,3UW77@52018,COG0462@1,COG0462@2	NA|NA|NA	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MAG.T12.45_02438	28042.GU90_04150	1.2e-155	556.6	Pseudonocardiales	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528,ko:K16203	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000,ko01002	3.A.1.5.2		iJN678.glmU,iLJ478.TM1629	Bacteria	2GJS1@201174,4DZZ7@85010,COG1207@1,COG1207@2	NA|NA|NA	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MAG.T12.45_02440	1123320.KB889688_gene428	1.3e-57	229.6	Actinobacteria	icaR												Bacteria	2GMBW@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_02441	593907.Celgi_0587	6.2e-52	210.7	Cellulomonadaceae	pecS												Bacteria	2GJ6W@201174,4F19N@85016,COG1846@1,COG1846@2	NA|NA|NA	K	PFAM regulatory protein MarR
MAG.T12.45_02442	929712.KI912613_gene4331	2.1e-173	615.9	Rubrobacteria	yjjK			ko:K15738					ko00000,ko02000	3.A.1.120.6			Bacteria	2GJ5M@201174,4CRTW@84995,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_02443	1304865.JAGF01000001_gene92	7.7e-60	237.7	Actinobacteria	manA		5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000				Bacteria	2I8X4@201174,COG1482@1,COG1482@2	NA|NA|NA	G	mannose-6-phosphate isomerase
MAG.T12.45_02444	446471.Xcel_2724	7.4e-76	290.8	Promicromonosporaceae	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29		iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	Bacteria	2GKXD@201174,4F3UP@85017,COG1947@1,COG1947@2	NA|NA|NA	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MAG.T12.45_02445	1032480.MLP_27790	7.1e-88	331.3	Propionibacteriales													Bacteria	2GP0C@201174,4DS7R@85009,COG1409@1,COG1409@2	NA|NA|NA	S	Calcineurin-like phosphoesterase
MAG.T12.45_02446	67257.JODR01000011_gene5452	5.9e-88	330.9	Actinobacteria	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528			R10716	RC00003,RC03257	ko00000,ko01000,ko03009				Bacteria	2GKBT@201174,COG0030@1,COG0030@2	NA|NA|NA	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MAG.T12.45_02447	1120950.KB892810_gene7207	4.5e-64	251.1	Propionibacteriales	tatD			ko:K03424					ko00000,ko01000				Bacteria	2GMJJ@201174,4DPJ5@85009,COG0084@1,COG0084@2	NA|NA|NA	L	TatD related DNase
MAG.T12.45_02448	1035308.AQYY01000001_gene2432	9.1e-40	169.9	Clostridia													Bacteria	1VQQ3@1239,255AM@186801,COG5646@1,COG5646@2	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T12.45_02449	882083.SacmaDRAFT_2733	1.2e-27	130.6	Pseudonocardiales	crtY		1.14.19.49,5.5.1.19	ko:K06443,ko:K14257	ko00253,ko00404,ko00906,ko01057,ko01100,ko01110,ko01130,map00253,map00404,map00906,map01057,map01100,map01110,map01130	M00097,M00790,M00823	R03824,R04801,R05341,R05456,R06962,R07856,R11106,R11478	RC00949,RC01004,RC01964	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNH7@201174,4E8RQ@85010,COG0644@1,COG0644@2	NA|NA|NA	C	Lycopene cyclase protein
MAG.T12.45_02452	1123320.KB889698_gene9326	3e-100	371.7	Actinobacteria	hbd		1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120		R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000				Bacteria	2GJBM@201174,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase
MAG.T12.45_02453	1146883.BLASA_3913	5.2e-160	570.9	Frankiales	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100		R00660	RC00350	ko00000,ko00001,ko01000,ko01011				Bacteria	2GJPW@201174,4ERJ6@85013,COG0766@1,COG0766@2	NA|NA|NA	M	Belongs to the EPSP synthase family. MurA subfamily
MAG.T12.45_02454	585531.HMPREF0063_12237	1.1e-66	259.6	Propionibacteriales	yvqK		2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMHN@201174,4DNZ5@85009,COG2096@1,COG2096@2	NA|NA|NA	S	Cobalamin adenosyltransferase
MAG.T12.45_02455	1268303.RHODMAR_0120	1e-75	290.4	Nocardiaceae													Bacteria	2GP1D@201174,4G9DV@85025,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T12.45_02456	543632.JOJL01000008_gene5609	1.5e-84	319.7	Micromonosporales	exoM												Bacteria	2GKTW@201174,4DIHT@85008,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
MAG.T12.45_02457	58344.JOEL01000006_gene4701	3.4e-56	226.5	Actinobacteria													Bacteria	2GMYJ@201174,COG2244@1,COG2244@2	NA|NA|NA	G	outer membrane autotransporter barrel domain protein
MAG.T12.45_02460	526225.Gobs_0437	7.3e-45	188.3	Frankiales													Bacteria	2GMYJ@201174,4EVNC@85013,COG2244@1,COG2244@2	NA|NA|NA	S	polysaccharide biosynthetic process
MAG.T12.45_02461	797302.Halru_2865	6e-09	68.9	Halobacteria													Archaea	23U89@183963,2XUFQ@28890,COG3919@1,arCOG06897@2157	NA|NA|NA	S	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
MAG.T12.45_02462	1089544.KB912942_gene1730	5.9e-78	298.1	Pseudonocardiales													Bacteria	2I92N@201174,4DXBA@85010,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM glycoside hydrolase family 39
MAG.T12.45_02463	1996.JOFO01000033_gene1260	3.2e-77	295.8	Actinobacteria													Bacteria	2GKTW@201174,COG1216@1,COG1216@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T12.45_02464	1144275.COCOR_04546	3.2e-61	242.7	Bacteria													Bacteria	COG2273@1,COG2273@2	NA|NA|NA	G	xyloglucan:xyloglucosyl transferase activity
MAG.T12.45_02465	566461.SSFG_02307	1.1e-23	116.3	Actinobacteria	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2IHNZ@201174,COG0355@1,COG0355@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane
MAG.T12.45_02466	1504319.GM45_6105	2.2e-126	458.4	unclassified Actinobacteria (class)	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1			Bacteria	2GIY6@201174,3UW86@52018,COG0055@1,COG0055@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MAG.T12.45_02469	1120950.KB892743_gene3151	4.8e-130	471.5	Propionibacteriales	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05364	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01011				Bacteria	2GJUQ@201174,4DP0A@85009,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin binding protein transpeptidase domain
MAG.T12.45_02470	935866.JAER01000017_gene4377	3.7e-119	435.3	Propionibacteriales	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136		ko:K03588,ko:K05364,ko:K05837	ko00550,ko04112,map00550,map04112		R04519	RC00005,RC00049	ko00000,ko00001,ko01011,ko02000,ko03036	2.A.103.1			Bacteria	2GJTI@201174,4DPN4@85009,COG0772@1,COG0772@2	NA|NA|NA	D	Belongs to the SEDS family
MAG.T12.45_02471	1449346.JQMO01000003_gene4362	1.8e-77	297.0	Kitasatospora			3.1.3.16	ko:K20074					ko00000,ko01000,ko01009				Bacteria	2GJ3M@201174,2M11G@2063,COG0631@1,COG0631@2	NA|NA|NA	T	Protein phosphatase 2C
MAG.T12.45_02472	561175.KB894093_gene3929	1.7e-34	152.5	Streptosporangiales	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944											Bacteria	2GKA7@201174,4EJS2@85012,COG1716@1,COG1716@2	NA|NA|NA	T	Inner membrane component of T3SS, cytoplasmic domain
MAG.T12.45_02473	266940.Krad_0077	1.2e-54	219.9	Actinobacteria	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363		ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GNU2@201174,COG1716@1,COG1716@2	NA|NA|NA	T	(FHA) domain
MAG.T12.45_02474	1380346.JNIH01000032_gene1139	5.2e-62	245.4	Actinobacteria			2.7.4.9	ko:K00943,ko:K08217	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22			Bacteria	2GK5A@201174,COG2270@1,COG2270@2	NA|NA|NA	S	Major facilitator Superfamily
MAG.T12.45_02475	1003195.SCAT_3138	3.6e-175	620.9	Actinobacteria	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130		R07324	RC01804	ko00000,ko00001,ko01000				Bacteria	2GKHB@201174,COG1260@1,COG1260@2	NA|NA|NA	I	myo-inositol-1-phosphate synthase
MAG.T12.45_02476	1210045.ALNP01000002_gene4122	1.5e-64	252.7	Actinobacteria	laaE												Bacteria	2GMJM@201174,COG1695@1,COG1695@2	NA|NA|NA	K	Transcriptional regulator
MAG.T12.45_02477	710696.Intca_0624	1.4e-151	542.7	Intrasporangiaceae													Bacteria	2IAMG@201174,4FFB5@85021,COG0427@1,COG0427@2	NA|NA|NA	C	4-hydroxybutyrate CoA-transferase
MAG.T12.45_02478	1122933.JNIY01000004_gene2358	6e-37	161.0	Cellulomonadaceae													Bacteria	2I2GH@201174,4F1NA@85016,COG3583@1,COG3583@2	NA|NA|NA	S	G5
MAG.T12.45_02479	1380356.JNIK01000021_gene4538	5.3e-69	267.7	Actinobacteria	glpF			ko:K02440,ko:K06188					ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2			Bacteria	2GKK3@201174,COG0580@1,COG0580@2	NA|NA|NA	G	Belongs to the MIP aquaporin (TC 1.A.8) family
MAG.T12.45_02480	1140001.I571_02495	5.1e-36	157.5	Enterococcaceae	cca		2.7.7.19,2.7.7.72	ko:K00970,ko:K00974,ko:K19545	ko03013,ko03018,map03013,map03018		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko01504,ko03016,ko03019				Bacteria	1V1W2@1239,4B2N1@81852,4HVHZ@91061,COG0617@1,COG0617@2	NA|NA|NA	J	Aminoglycoside-2''-adenylyltransferase
MAG.T12.45_02482	266117.Rxyl_2066	7.5e-115	421.4	Rubrobacteria	oatA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K19172					ko00000,ko02048				Bacteria	2GKI5@201174,4CQDA@84995,COG1835@1,COG1835@2,COG2755@1,COG2755@2	NA|NA|NA	I	Acyltransferase family
MAG.T12.45_02483	1463887.KL590002_gene4201	5.8e-20	104.4	Actinobacteria													Bacteria	2IIEK@201174,COG1670@1,COG1670@2	NA|NA|NA	J	Acetyltransferase (GNAT) domain
MAG.T12.45_02484	1157632.AQWQ01000003_gene1787	3.3e-176	624.8	Actinobacteria	cca		2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019				Bacteria	2GMT1@201174,COG0617@1,COG0617@2	NA|NA|NA	J	tRNA nucleotidyltransferase poly(A) polymerase
MAG.T12.45_02485	675635.Psed_6673	8.7e-49	200.7	Pseudonocardiales													Bacteria	2I2DG@201174,4E30H@85010,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
MAG.T12.45_02487	1385519.N801_04205	2.1e-131	475.7	Intrasporangiaceae													Bacteria	2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
MAG.T12.45_02488	1101188.KI912157_gene87	1.6e-21	109.8	Actinobacteria													Bacteria	2EKKY@1,2I2JI@201174,33EAR@2	NA|NA|NA		
MAG.T12.45_02490	1035308.AQYY01000002_gene68	6.8e-29	135.2	Bacteria													Bacteria	COG1652@1,COG1652@2,COG3170@1,COG3170@2	NA|NA|NA	S	positive regulation of growth rate
MAG.T12.45_02491	134676.ACPL_5887	3.5e-15	88.2	Micromonosporales													Bacteria	2E4ST@1,2GSCH@201174,32ZM5@2,4DEKN@85008	NA|NA|NA	S	Putative Flp pilus-assembly TadE/G-like
MAG.T12.45_02492	196162.Noca_2227	4.5e-15	87.8	Propionibacteriales													Bacteria	2GRCJ@201174,4DSH3@85009,COG4961@1,COG4961@2	NA|NA|NA	U	overlaps another CDS with the same product name
MAG.T12.45_02493	110319.CF8_1721	3.6e-41	175.6	Propionibacteriales													Bacteria	2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009	NA|NA|NA		
MAG.T12.45_02495	526225.Gobs_0675	9e-21	106.7	Actinobacteria													Bacteria	2I36X@201174,COG4961@1,COG4961@2	NA|NA|NA	U	overlaps another CDS with the same product name
MAG.T12.45_02497	397278.JOJN01000013_gene2572	3e-50	205.7	Propionibacteriales				ko:K12511					ko00000,ko02044				Bacteria	2HZTC@201174,4DRIG@85009,COG2064@1,COG2064@2	NA|NA|NA	NU	type II secretion system protein
MAG.T12.45_02498	1385519.N801_09660	2.3e-52	212.6	Intrasporangiaceae													Bacteria	2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2	NA|NA|NA	U	Type II secretion system (T2SS), protein F
MAG.T12.45_02499	110319.CF8_2349	3.2e-110	405.6	Propionibacteriales				ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GKKJ@201174,4DWY1@85009,COG4962@1,COG4962@2	NA|NA|NA	U	PFAM type II secretion system protein E
MAG.T12.45_02500	110319.CF8_2348	2.7e-39	169.1	Propionibacteriales													Bacteria	2I57A@201174,4DWY4@85009,COG1192@1,COG1192@2	NA|NA|NA	D	Involved in chromosome partitioning
MAG.T12.45_02501	196162.Noca_2220	8.4e-29	134.0	Propionibacteriales													Bacteria	2HIQE@201174,4DWST@85009,COG1261@1,COG1261@2	NA|NA|NA	NO	SAF
MAG.T12.45_02505	397278.JOJN01000001_gene2848	2.2e-81	309.7	Propionibacteriales													Bacteria	2I9AH@201174,4DMZA@85009,COG1403@1,COG1403@2	NA|NA|NA	V	HNH nucleases
MAG.T12.45_02506	58123.JOFJ01000012_gene5336	1.5e-31	144.1	Streptosporangiales													Bacteria	2IBIC@201174,4EH95@85012,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_02509	1385519.N801_06575	7.2e-173	613.6	Intrasporangiaceae													Bacteria	2GJE2@201174,4FHMX@85021,COG3103@1,COG4991@2	NA|NA|NA	T	Peptidoglycan-binding protein
MAG.T12.45_02512	1121372.AULK01000001_gene1922	3e-78	298.5	Microbacteriaceae													Bacteria	2GJUE@201174,4FPKA@85023,COG2267@1,COG2267@2	NA|NA|NA	I	Alpha/beta hydrolase family
MAG.T12.45_02513	1298863.AUEP01000017_gene4145	1.3e-147	530.0	Propionibacteriales	sulP	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3		iSbBS512_1146.SbBS512_E1370	Bacteria	2GJCB@201174,4DNAM@85009,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate permease family
MAG.T12.45_02514	1298863.AUEP01000017_gene4144	8.8e-32	142.9	Propionibacteriales	arsR9			ko:K03892					ko00000,ko03000				Bacteria	2IKK2@201174,4DRX6@85009,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T12.45_02515	1001240.GY21_03890	4.7e-163	581.3	Microbacteriaceae	hycE			ko:K14089					ko00000				Bacteria	2GYM5@201174,4FSFF@85023,COG3261@1,COG3261@2,COG3262@1,COG3262@2	NA|NA|NA	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit
MAG.T12.45_02516	196162.Noca_4466	5.8e-139	501.1	Propionibacteriales	hyfF			ko:K12141					ko00000,ko01000				Bacteria	2HAC7@201174,4DTN6@85009,COG0651@1,COG0651@2	NA|NA|NA	CP	Proton-conducting membrane transporter
MAG.T12.45_02517	1001240.GY21_03900	8.6e-45	187.2	Microbacteriaceae	hyfE	GO:0008150,GO:0040007		ko:K12140					ko00000,ko01000				Bacteria	2HQ3P@201174,4FQSR@85023,COG4237@1,COG4237@2	NA|NA|NA	C	Hydrogenase 4 membrane
MAG.T12.45_02518	1001240.GY21_03905	1.5e-95	356.3	Microbacteriaceae	hycD												Bacteria	2GJFM@201174,4FPM3@85023,COG0650@1,COG0650@2	NA|NA|NA	C	NADH dehydrogenase
MAG.T12.45_02519	196162.Noca_4469	4.4e-190	671.4	Propionibacteriales	hyfB												Bacteria	2HAC7@201174,4DSYG@85009,COG0651@1,COG0651@2	NA|NA|NA	CP	Proton-conducting membrane transporter
MAG.T12.45_02520	196162.Noca_4470	4.6e-59	234.2	Propionibacteriales	hycG												Bacteria	2IDTD@201174,4DUTR@85009,COG3260@1,COG3260@2	NA|NA|NA	C	NADH ubiquinone oxidoreductase, 20 Kd subunit
MAG.T12.45_02522	570268.ANBB01000058_gene4298	3.8e-44	185.3	Streptosporangiales													Bacteria	2GIT8@201174,4EG60@85012,COG3177@1,COG3177@2	NA|NA|NA	S	Filamentation induced by cAMP protein fic
MAG.T12.45_02523	1077972.ARGLB_008_01400	2.1e-20	106.7	Micrococcaceae	cpaE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464		ko:K04562					ko00000,ko02035				Bacteria	1W9WT@1268,2GIVN@201174,COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T12.45_02524	1123320.KB889692_gene178	2e-110	406.0	Actinobacteria	cpaF			ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GKKJ@201174,COG4962@1,COG4962@2	NA|NA|NA	U	Type ii secretion system protein e
MAG.T12.45_02525	479432.Sros_0481	3.1e-23	115.5	Streptosporangiales				ko:K12510					ko00000,ko02044				Bacteria	2I8NR@201174,4EJYE@85012,COG4965@1,COG4965@2	NA|NA|NA	U	Type II secretion system (T2SS), protein F
MAG.T12.45_02526	2002.JOEQ01000043_gene5988	5.7e-26	124.8	Streptosporangiales	gspF			ko:K12510,ko:K12511					ko00000,ko02044				Bacteria	2IQE9@201174,4EJVY@85012,COG2064@1,COG2064@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein F
MAG.T12.45_02528	28444.JODQ01000014_gene6780	1.2e-11	76.3	Streptosporangiales		GO:0008150,GO:0010941,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0060548,GO:0065007											Bacteria	2EGB2@1,2GWPQ@201174,33A2X@2,4EKNC@85012	NA|NA|NA		
MAG.T12.45_02530	397278.JOJN01000002_gene505	3.9e-228	798.1	Propionibacteriales	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K06877					ko00000				Bacteria	2GJJ6@201174,4DNQG@85009,COG1205@1,COG1205@2	NA|NA|NA	L	Domain of unknown function (DUF1998)
MAG.T12.45_02531	298653.Franean1_0312	4.5e-23	114.0	Frankiales	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K04749					ko00000,ko03021				Bacteria	2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2	NA|NA|NA	T	Belongs to the anti-sigma-factor antagonist family
MAG.T12.45_02532	47716.JOFH01000021_gene4179	2.4e-15	88.6	Actinobacteria			2.7.11.1	ko:K04757					ko00000,ko01000,ko01001,ko03021				Bacteria	2IHNR@201174,COG2172@1,COG2172@2	NA|NA|NA	T	anti-sigma regulatory factor
MAG.T12.45_02533	710696.Intca_0155	8.2e-60	237.3	Intrasporangiaceae			3.5.1.104	ko:K22278					ko00000,ko01000				Bacteria	2HEQK@201174,4FHJZ@85021,COG0726@1,COG0726@2	NA|NA|NA	G	Polysaccharide deacetylase
MAG.T12.45_02534	1278308.KB907085_gene36	7.3e-11	73.6	Microbacteriaceae	glxI		4.4.1.5	ko:K01759	ko00620,map00620		R02530	RC00004,RC00740	ko00000,ko00001,ko01000				Bacteria	2GVCV@201174,4FSM4@85023,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase-like domain
MAG.T12.45_02535	1146883.BLASA_1786	1.8e-208	731.9	Frankiales													Bacteria	2GJK7@201174,4ES3E@85013,COG3464@1,COG3464@2	NA|NA|NA	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein
MAG.T12.45_02536	570268.ANBB01000050_gene4013	1.9e-56	226.5	Actinobacteria													Bacteria	2GKV2@201174,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_02537	298655.KI912266_gene5611	1.4e-74	286.6	Frankiales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter
MAG.T12.45_02538	471853.Bcav_0362	1.2e-18	100.5	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2IRIX@201174,COG1277@1,COG1277@2	NA|NA|NA	S	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAG.T12.45_02539	1121946.AUAX01000004_gene744	7.2e-17	94.4	Micromonosporales													Bacteria	2GKW3@201174,4DDW4@85008,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_02541	1536773.R70331_22715	2.3e-65	256.1	Paenibacillaceae			1.6.5.5	ko:K00344					ko00000,ko01000				Bacteria	1TZGF@1239,26UA2@186822,4HEDQ@91061,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding alcohol dehydrogenase
MAG.T12.45_02542	471853.Bcav_2640	7.2e-90	338.2	Actinobacteria	PPA1638			ko:K06883					ko00000				Bacteria	2GM68@201174,COG0699@1,COG0699@2	NA|NA|NA	K	ABC transporter
MAG.T12.45_02543	1077972.ARGLB_050_00040	5e-132	478.4	Micrococcaceae				ko:K06883					ko00000				Bacteria	1W8MB@1268,2GJX9@201174,COG0699@1,COG0699@2	NA|NA|NA	S	Dynamin family
MAG.T12.45_02545	497964.CfE428DRAFT_0631	9.1e-12	76.3	Verrucomicrobia													Bacteria	46TZ3@74201,COG2114@1,COG2114@2,COG3903@1,COG3903@2	NA|NA|NA	T	Adenylyl- / guanylyl cyclase, catalytic domain
MAG.T12.45_02546	1122933.JNIY01000003_gene883	3.1e-19	101.7	Cellulomonadaceae				ko:K07552					ko00000,ko02000	2.A.1.2			Bacteria	2GJK6@201174,4F33C@85016,COG0477@1,COG2814@2	NA|NA|NA	EGP	Sugar (and other) transporter
MAG.T12.45_02547	408672.NBCG_01925	1.2e-88	333.2	Propionibacteriales			3.2.1.83	ko:K20846					ko00000,ko01000		GH16		Bacteria	2GTJC@201174,4DQGW@85009,COG2273@1,COG2273@2	NA|NA|NA	G	Glycosyl hydrolases family 16
MAG.T12.45_02548	1120950.KB892775_gene1183	2e-127	462.6	Propionibacteriales	arsB												Bacteria	2GMQJ@201174,4DN5A@85009,COG1055@1,COG1055@2	NA|NA|NA	P	Bacterial Na+/H+ antiporter B (NhaB)
MAG.T12.45_02549	710421.Mycch_1475	1.3e-96	359.4	Mycobacteriaceae	ahpC		1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	234SP@1762,2GM74@201174,COG0450@1,COG0450@2	NA|NA|NA	O	Alkyl hydroperoxide reductase
MAG.T12.45_02550	526222.Desal_3467	1.7e-67	263.1	Desulfovibrionales													Bacteria	1RAKG@1224,2MAVS@213115,2WN6A@28221,42QYD@68525,COG2199@1,COG3706@2	NA|NA|NA	T	Diguanylate cyclase, GGDEF domain
MAG.T12.45_02551	937777.Deipe_2178	1.3e-29	137.9	Bacteria			3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T12.45_02552	1035308.AQYY01000001_gene1812	2.1e-87	329.7	Bacteria													Bacteria	COG4325@1,COG4325@2	NA|NA|NA		
MAG.T12.45_02553	671143.DAMO_1527	7.2e-63	247.7	unclassified Bacteria	yrbG			ko:K07301					ko00000,ko02000	2.A.19.5			Bacteria	2NPPD@2323,COG0530@1,COG0530@2	NA|NA|NA	P	Sodium/calcium exchanger protein
MAG.T12.45_02554	103733.JNYO01000019_gene2036	3.5e-119	434.9	Pseudonocardiales													Bacteria	2C1EG@1,2GK4W@201174,2Z7MZ@2,4DZP1@85010	NA|NA|NA		
MAG.T12.45_02555	471853.Bcav_3980	9.5e-152	543.5	Actinobacteria													Bacteria	2GJ8H@201174,COG3119@1,COG3119@2	NA|NA|NA	P	Pfam Sulfatase
MAG.T12.45_02556	1449355.JQNR01000003_gene273	2.7e-55	222.2	Actinobacteria	yvaK		3.1.1.1	ko:K03928					ko00000,ko01000				Bacteria	2GM1Y@201174,COG1647@1,COG1647@2	NA|NA|NA	S	Esterase
MAG.T12.45_02557	55952.BU52_09430	6.2e-22	110.5	Actinobacteria													Bacteria	2E49S@1,2I83P@201174,32RRE@2	NA|NA|NA	S	Protein of unknown function (DUF3040)
MAG.T12.45_02558	1172188.KB911827_gene4382	3e-136	491.9	Intrasporangiaceae	dinB		2.7.7.7	ko:K02346					ko00000,ko01000,ko03400				Bacteria	2GKBI@201174,4FE61@85021,COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAG.T12.45_02559	1121017.AUFG01000001_gene3000	0.0	1368.2	Intrasporangiaceae	dnaE2		2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ1P@201174,4FEK0@85021,COG0587@1,COG0587@2	NA|NA|NA	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily
MAG.T12.45_02560	1380356.JNIK01000021_gene4429	6.4e-27	127.1	Frankiales													Bacteria	2CGM3@1,2GP7H@201174,32S47@2,4ET5Q@85013	NA|NA|NA		
MAG.T12.45_02561	1123320.KB889675_gene3873	1.9e-20	105.1	Actinobacteria													Bacteria	2ERD0@1,2GVR1@201174,33IYN@2	NA|NA|NA		
MAG.T12.45_02562	1146883.BLASA_0920	3e-69	268.5	Frankiales	crtA		1.14.15.9	ko:K09847	ko00906,ko01100,map00906,map01100		R07525,R07526,R07537,R07538	RC02084	ko00000,ko00001,ko01000				Bacteria	29UQ5@1,2II02@201174,30G1W@2,4EV3Q@85013	NA|NA|NA	C	spheroidene monooxygenase
MAG.T12.45_02564	1048339.KB913029_gene4359	1.3e-49	203.4	Frankiales			5.5.1.19	ko:K22502	ko00906,map00906		R03824,R05341	RC01004	ko00000,ko00001,ko01000				Bacteria	2IIUJ@201174,4EVC1@85013,COG2324@1,COG2324@2	NA|NA|NA	S	Carotenoid biosynthesis protein
MAG.T12.45_02565	266940.Krad_3224	2.5e-92	345.9	Actinobacteria				ko:K14597	ko00906,map00906		R07544,R07546	RC00262	ko00000,ko00001				Bacteria	2GJZI@201174,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase, family 2
MAG.T12.45_02566	1380356.JNIK01000013_gene4257	2.2e-170	605.5	Frankiales	crtD		1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9	ko:K01854,ko:K09845,ko:K10027	ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110		R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692	RC00317,RC01214,RC02080,RC02088,RC02396,RC02605	ko00000,ko00001,ko01000				Bacteria	2GJAV@201174,4ETTQ@85013,COG1233@1,COG1233@2	NA|NA|NA	Q	Flavin containing amine oxidoreductase
MAG.T12.45_02567	1246995.AFR_10060	1.1e-119	437.2	Micromonosporales	cvrA			ko:K11105					ko00000,ko02000	2.A.36.6			Bacteria	2GJ9B@201174,4D9E3@85008,COG3263@1,COG3263@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T12.45_02568	326424.FRAAL2165	2.4e-41	175.6	Frankiales			2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100		R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	2IDSP@201174,4ET6D@85013,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T12.45_02569	1380347.JNII01000005_gene3165	8.8e-25	120.6	Frankiales				ko:K09807					ko00000				Bacteria	2GM1U@201174,4ET95@85013,COG2968@1,COG2968@2	NA|NA|NA	S	Protein of unknown function (DUF541)
MAG.T12.45_02570	1048339.KB913029_gene4363	5.3e-100	370.9	Frankiales	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJTN@201174,4ERKZ@85013,COG0685@1,COG0685@2	NA|NA|NA	E	Methylenetetrahydrofolate reductase
MAG.T12.45_02571	1123320.KB889675_gene3878	3.8e-108	398.3	Actinobacteria	idsA		2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	2GJEK@201174,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
MAG.T12.45_02572	1504319.GM45_1000	9.1e-201	706.4	unclassified Actinobacteria (class)	crtI		1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110		R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000				Bacteria	2GJAV@201174,3UXB3@52018,COG1233@1,COG1233@2	NA|NA|NA	Q	Flavin containing amine oxidoreductase
MAG.T12.45_02573	1121019.AUMN01000024_gene3573	7.3e-84	318.2	Micrococcaceae				ko:K14337,ko:K14339					ko00000,ko01000,ko01003				Bacteria	1WCDZ@1268,2AMJ0@1,2I3ZG@201174,31CER@2	NA|NA|NA		
MAG.T12.45_02574	1155718.KB891896_gene2107	4.6e-13	81.3	Actinobacteria													Bacteria	2IKZ0@201174,COG2732@1,COG2732@2	NA|NA|NA	K	Barstar (barnase inhibitor)
MAG.T12.45_02575	29306.JOBE01000002_gene2854	2.8e-28	131.7	Actinobacteria			3.1.27.3	ko:K01167,ko:K15125	ko05133,map05133				ko00000,ko00001,ko00536,ko01000,ko03016,ko03019				Bacteria	2IHPV@201174,COG4290@1,COG4290@2	NA|NA|NA	F	Ribonuclease
MAG.T12.45_02576	1504319.GM45_0995	1.4e-90	339.7	unclassified Actinobacteria (class)	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	2HFT6@201174,3UXMW@52018,COG1562@1,COG1562@2	NA|NA|NA	I	Squalene/phytoene synthase
MAG.T12.45_02577	1246995.AFR_09710	1.2e-25	123.2	Micromonosporales													Bacteria	2E9MI@1,2IMX9@201174,333U6@2,4DG5M@85008	NA|NA|NA	S	lycopene cyclase
MAG.T12.45_02578	134676.ACPL_1706	2e-29	135.6	Micromonosporales	crtY												Bacteria	2CPEY@1,2I84R@201174,32SIY@2,4DFG6@85008	NA|NA|NA	S	lycopene cyclase domain
MAG.T12.45_02579	1463841.JOIR01000003_gene5736	3.7e-22	112.1	Actinobacteria	fprE		1.18.1.3,1.7.1.15	ko:K00362,ko:K00529	ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R02000,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJKT@201174,COG0446@1,COG0446@2	NA|NA|NA	Q	pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_02581	590998.Celf_3048	2.6e-29	136.3	Actinobacteria	rlpA			ko:K03642,ko:K03749					ko00000				Bacteria	2I8WA@201174,COG3147@1,COG3147@2	NA|NA|NA	N	Non-essential cell division protein that could be required for efficient cell constriction
MAG.T12.45_02582	31964.CMS2390	9.4e-72	277.3	Microbacteriaceae	gumI		2.4.1.251	ko:K13658			R09734	RC00005,RC00049	ko00000,ko01000,ko01003				Bacteria	2IAJJ@201174,4FMGW@85023,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T12.45_02583	1380354.JIAN01000008_gene3362	5.1e-64	252.3	Actinobacteria			3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020		R02886,R11308	RC00799	ko00000,ko00001,ko01000		GH6		Bacteria	2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2	NA|NA|NA	P	PFAM PKD domain containing protein
MAG.T12.45_02584	526225.Gobs_0501	6.2e-249	866.7	Frankiales	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GISX@201174,4ERVK@85013,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAG.T12.45_02585	1288083.AUKR01000014_gene2876	3.9e-109	402.5	Actinobacteria													Bacteria	2GKI5@201174,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase
MAG.T12.45_02587	1121017.AUFG01000004_gene3201	7.9e-70	270.0	Intrasporangiaceae	def		3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	2GJ87@201174,4FG5A@85021,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MAG.T12.45_02588	1449353.JQMQ01000005_gene829	2e-121	442.2	Streptacidiphilus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.1.176,2.1.2.9	ko:K00604,ko:K03500	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000,ko03009			iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Bacteria	2GKH5@201174,2NH3A@228398,COG0223@1,COG0223@2	NA|NA|NA	J	Formyl transferase, C-terminal domain
MAG.T12.45_02589	2045.KR76_14595	4e-110	405.2	Propionibacteriales	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176,5.3.1.9	ko:K01810,ko:K03500	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147				Bacteria	2GM21@201174,4DP4E@85009,COG0144@1,COG0144@2,COG0781@1,COG0781@2	NA|NA|NA	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
MAG.T12.45_02590	1048339.KB913029_gene4006	1.6e-88	332.4	Frankiales	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZ9@201174,4ERMA@85013,COG0036@1,COG0036@2	NA|NA|NA	G	Belongs to the ribulose-phosphate 3-epimerase family
MAG.T12.45_02591	743718.Isova_1506	3.2e-104	385.2	Promicromonosporaceae	ribD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193,3.5.4.26	ko:K01498,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1624,iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iLJ478.TM1828,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524	Bacteria	2GKAX@201174,4F42N@85017,COG0117@1,COG0117@2,COG1985@1,COG1985@2	NA|NA|NA	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MAG.T12.45_02592	1449355.JQNR01000005_gene5307	5.5e-64	250.8	Actinobacteria	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9,3.5.4.25,4.1.99.12	ko:K00793,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00066,R00425,R07281	RC00293,RC00958,RC00960,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS08950	Bacteria	2GKC5@201174,COG0307@1,COG0307@2	NA|NA|NA	H	riboflavin synthase, alpha
MAG.T12.45_02594	1184607.AUCHE_05_06140	2.2e-65	255.0	Dermatophilaceae	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02356					ko00000,ko03012				Bacteria	2GJMS@201174,4F6K1@85018,COG0231@1,COG0231@2	NA|NA|NA	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MAG.T12.45_02595	196162.Noca_2418	5.1e-40	170.6	Propionibacteriales	nusB	GO:0008150,GO:0040007		ko:K03625					ko00000,ko03009,ko03021				Bacteria	2IM3D@201174,4DR4N@85009,COG0781@1,COG0781@2	NA|NA|NA	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MAG.T12.45_02596	1229781.C272_07005	2.2e-57	228.8	Brevibacteriaceae	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944		ko:K22010		M00839			ko00000,ko00002,ko02022				Bacteria	2GK7T@201174,4F9CZ@85019,COG3707@1,COG3707@2	NA|NA|NA	T	ANTAR
MAG.T12.45_02598	561175.KB894094_gene1867	4.8e-75	287.7	Streptosporangiales	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205				ko00000,ko00001,ko01000,ko03009,ko03019,ko03036				Bacteria	2GKER@201174,4EGGX@85012,COG0571@1,COG0571@2	NA|NA|NA	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MAG.T12.45_02599	227882.SAV_2666	5.5e-17	92.8	Actinobacteria	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904		ko:K02911	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	2GQP3@201174,COG0333@1,COG0333@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL32 family
MAG.T12.45_02600	110319.CF8_2880	6.2e-51	207.2	Propionibacteriales	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464		ko:K07040					ko00000				Bacteria	2GJTS@201174,4DQUU@85009,COG1399@1,COG1399@2	NA|NA|NA	S	Uncharacterized ACR, COG1399
MAG.T12.45_02601	1463921.JODF01000032_gene2667	1.8e-16	92.8	Actinobacteria													Bacteria	2GNBF@201174,COG0711@1,COG0711@2	NA|NA|NA	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAG.T12.45_02602	1435356.Y013_00915	5.7e-17	92.8	Nocardiaceae	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN1S@201174,4G0KI@85025,COG0669@1,COG0669@2	NA|NA|NA	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MAG.T12.45_02605	369723.Strop_1612	3.1e-58	231.5	Micromonosporales	perX												Bacteria	2IFXH@201174,4DIG7@85008,COG2210@1,COG2210@2	NA|NA|NA	S	DsrE/DsrF/DrsH-like family
MAG.T12.45_02606	1144275.COCOR_03122	6.6e-25	120.2	Proteobacteria													Bacteria	1NKMZ@1224,COG3832@1,COG3832@2,COG5646@1,COG5646@2	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T12.45_02607	679197.HMPREF9336_04200	8.2e-58	231.5	Actinobacteria													Bacteria	2GN56@201174,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase
MAG.T12.45_02608	479435.Kfla_5620	1.3e-12	80.5	Propionibacteriales													Bacteria	2B5R0@1,2IPMA@201174,31YKI@2,4DR93@85009	NA|NA|NA		
MAG.T12.45_02609	1120954.ATXE01000001_gene2216	3.3e-20	104.8	Propionibacteriales													Bacteria	2IT3M@201174,4DVDP@85009,COG3877@1,COG3877@2	NA|NA|NA	S	Protein of unknown function (DUF2089)
MAG.T12.45_02610	477641.MODMU_4177	2.4e-105	388.7	Frankiales			1.13.11.8	ko:K04100,ko:K15777	ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120		R01632,R03550,R04280,R08836,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000				Bacteria	2GKTV@201174,4ESG8@85013,COG3384@1,COG3384@2	NA|NA|NA	S	Extradiol ring-cleavage dioxygenase class III protein subunit B
MAG.T12.45_02611	1240349.ANGC01000010_gene2821	1.8e-92	346.7	Nocardiaceae			2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000				Bacteria	2IGNH@201174,4G6IZ@85025,COG1020@1,COG1020@2	NA|NA|NA	I	Protein of unknown function (DUF1298)
MAG.T12.45_02612	479435.Kfla_0631	2.2e-30	139.0	Propionibacteriales	lytE			ko:K21471					ko00000,ko01000,ko01002,ko01011				Bacteria	2IFNI@201174,4DS9B@85009,COG0791@1,COG0791@2,COG3409@1,COG3409@2	NA|NA|NA	M	NlpC/P60 family
MAG.T12.45_02613	1463820.JOGW01000004_gene4608	3.4e-21	107.5	Actinobacteria				ko:K21600					ko00000,ko03000				Bacteria	2IQ7U@201174,COG1937@1,COG1937@2	NA|NA|NA	S	protein conserved in bacteria
MAG.T12.45_02614	1206101.AZXC01000007_gene2475	3.7e-64	251.5	Actinobacteria	ideR			ko:K03709					ko00000,ko03000				Bacteria	2GKMC@201174,COG1321@1,COG1321@2	NA|NA|NA	K	iron dependent repressor
MAG.T12.45_02615	1123320.KB889746_gene8006	2.4e-136	492.3	Actinobacteria	phrB	GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0018298,GO:0019222,GO:0019538,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379	4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Bacteria	2GJXU@201174,COG0415@1,COG0415@2	NA|NA|NA	L	Belongs to the DNA photolyase family
MAG.T12.45_02616	1068980.ARVW01000001_gene8375	1.6e-52	213.0	Pseudonocardiales	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2H4UC@201174,4DZB6@85010,COG1192@1,COG1192@2	NA|NA|NA	D	involved in chromosome partitioning
MAG.T12.45_02619	287986.DV20_43550	2.9e-147	528.1	Pseudonocardiales													Bacteria	2H0AR@201174,4E90A@85010,COG0627@1,COG0627@2	NA|NA|NA	S	Putative esterase
MAG.T12.45_02620	543632.JOJL01000027_gene2595	1.1e-39	171.0	Micromonosporales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2I9MY@201174,4DCFI@85008,COG1668@1,COG1668@2	NA|NA|NA	CP	ABC-2 family transporter protein
MAG.T12.45_02621	469383.Cwoe_0732	5.3e-74	284.6	Actinobacteria				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2I2DK@201174,COG4152@1,COG4152@2	NA|NA|NA	S	ABC transporter
MAG.T12.45_02622	765420.OSCT_1250	1.3e-21	110.2	Chloroflexia				ko:K08981					ko00000				Bacteria	2G70V@200795,375QN@32061,COG3428@1,COG3428@2	NA|NA|NA	S	PFAM membrane-flanked domain
MAG.T12.45_02623	1449347.JQLN01000005_gene4049	3.1e-55	221.9	Kitasatospora	pdxH		1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJCR@201174,2M25F@2063,COG0259@1,COG0259@2	NA|NA|NA	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
MAG.T12.45_02624	285535.JOEY01000002_gene4814	4.7e-173	614.0	Actinobacteria	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GKST@201174,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T12.45_02625	644283.Micau_0514	8.6e-151	540.0	Micromonosporales	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKYK@201174,4D8WE@85008,COG1932@1,COG1932@2	NA|NA|NA	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MAG.T12.45_02626	1150864.MILUP08_42574	8.6e-43	179.9	Micromonosporales													Bacteria	2HR7I@201174,4DFE0@85008,COG2315@1,COG2315@2	NA|NA|NA	S	YjbR
MAG.T12.45_02627	1123320.KB889723_gene7524	2.9e-46	192.6	Actinobacteria													Bacteria	2GNAZ@201174,COG3386@1,COG3386@2	NA|NA|NA	G	PFAM SMP-30 Gluconolaconase
MAG.T12.45_02628	656024.FsymDg_0268	4.8e-07	60.5	Frankiales													Bacteria	2ETMT@1,2HU3T@201174,33M5J@2,4EWV2@85013	NA|NA|NA	S	Protein of unknown function (DUF2530)
MAG.T12.45_02629	1048339.KB913029_gene2148	2.2e-62	245.7	Frankiales													Bacteria	28NWB@1,2GJ74@201174,2ZBU7@2,4ESJV@85013	NA|NA|NA	S	Protein of unknown function (DUF3027)
MAG.T12.45_02630	1206101.AZXC01000007_gene2428	6.7e-09	67.4	Actinobacteria													Bacteria	2F261@1,2IFIE@201174,33V4D@2	NA|NA|NA		
MAG.T12.45_02631	743718.Isova_2592	7.1e-41	173.3	Promicromonosporaceae	cspB			ko:K03704					ko00000,ko03000				Bacteria	2IKXN@201174,4F4QM@85017,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock protein domain
MAG.T12.45_02633	1003195.SCAT_2429	5.2e-107	395.6	Actinobacteria	M1-1077												Bacteria	2GURQ@201174,COG2378@1,COG2378@2	NA|NA|NA	K	Helicase conserved C-terminal domain
MAG.T12.45_02634	471852.Tcur_0810	1.6e-251	875.2	Streptosporangiales	ercc3		3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290			ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2GIR9@201174,4EHX6@85012,COG1061@1,COG1061@2	NA|NA|NA	L	ERCC3/RAD25/XPB C-terminal helicase
MAG.T12.45_02635	477641.MODMU_4618	3.3e-47	194.9	Frankiales	bar		2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130		R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000				Bacteria	2IHSY@201174,4EVJN@85013,COG1247@1,COG1247@2	NA|NA|NA	M	Acetyltransferase (GNAT) domain
MAG.T12.45_02637	263358.VAB18032_03310	5.6e-59	235.3	Micromonosporales													Bacteria	2GKZ9@201174,4DGWY@85008,COG5555@1,COG5555@2	NA|NA|NA	N	Integrin alpha (beta-propellor repeats).
MAG.T12.45_02641	653386.HMPREF0975_01859	1.2e-38	165.6	Actinobacteria	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJD5@201174,4D4IX@85005,COG1048@1,COG1048@2	NA|NA|NA	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MAG.T12.45_02642	1146883.BLASA_3285	5.4e-22	110.5	Actinobacteria													Bacteria	2E8DB@1,2IHS0@201174,332RT@2	NA|NA|NA		
MAG.T12.45_02643	743718.Isova_1764	2.6e-229	801.6	Promicromonosporaceae	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0456,iIT341.HP0354,iJN746.PP_0527	Bacteria	2GMFA@201174,4F36H@85017,COG1154@1,COG1154@2	NA|NA|NA	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MAG.T12.45_02644	345341.KUTG_00976	1.4e-88	334.0	Pseudonocardiales													Bacteria	2GIZF@201174,4DYN9@85010,COG5001@1,COG5001@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T12.45_02645	1463858.JOHR01000014_gene5354	3.4e-125	455.3	Actinobacteria	rnd		3.1.13.5	ko:K03684					ko00000,ko01000,ko03016				Bacteria	2GKNM@201174,COG0349@1,COG0349@2	NA|NA|NA	J	3-5 exonuclease
MAG.T12.45_02646	1137271.AZUM01000001_gene1482	2.3e-25	122.5	Pseudonocardiales													Bacteria	2GIXT@201174,4DXKI@85010,COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T12.45_02647	1298863.AUEP01000018_gene3870	2.2e-54	218.8	Propionibacteriales													Bacteria	2AIF4@1,2GK8R@201174,318WM@2,4DQE6@85009	NA|NA|NA	S	Protein of unknown function (DUF3000)
MAG.T12.45_02648	1385519.N801_01520	1.7e-47	196.4	Intrasporangiaceae													Bacteria	2GM50@201174,4FGFA@85021,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T12.45_02649	1137269.AZWL01000022_gene3485	5e-119	434.5	Actinobacteria	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0016	Bacteria	2GMY6@201174,COG0407@1,COG0407@2	NA|NA|NA	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MAG.T12.45_02650	1380346.JNIH01000057_gene20	6.8e-119	434.5	Actinobacteria	hemG		1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMMA@201174,COG1232@1,COG1232@2	NA|NA|NA	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MAG.T12.45_02651	585531.HMPREF0063_10544	3e-85	321.6	Propionibacteriales	hemH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK24@201174,4DP69@85009,COG3253@1,COG3253@2	NA|NA|NA	S	Chlorite dismutase
MAG.T12.45_02652	640132.Srot_1648	1.7e-57	228.8	Actinobacteria	msrB		1.8.4.12	ko:K07305					ko00000,ko01000				Bacteria	2IHV0@201174,COG0229@1,COG0229@2	NA|NA|NA	O	peptide-methionine (R)-S-oxide reductase
MAG.T12.45_02653	1048339.KB913029_gene3893	1.6e-138	499.2	Frankiales													Bacteria	2GM0A@201174,4ES0F@85013,COG3285@1,COG3285@2	NA|NA|NA	L	DNA polymerase LigD
MAG.T12.45_02655	1136417.AZWE01000018_gene977	1.7e-77	296.6	Micromonosporales	ligC												Bacteria	2I2EA@201174,4DA61@85008,COG1793@1,COG1793@2	NA|NA|NA	L	DNA ligase
MAG.T12.45_02656	479431.Namu_3543	1.2e-29	136.7	Frankiales	ribG		1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN2P@201174,4ET37@85013,COG1985@1,COG1985@2	NA|NA|NA	H	PFAM bifunctional deaminase-reductase domain protein
MAG.T12.45_02657	1449346.JQMO01000002_gene2006	1.3e-118	433.0	Kitasatospora				ko:K06916					ko00000,ko03036				Bacteria	2GNQA@201174,2M1G2@2063,COG1485@1,COG1485@2	NA|NA|NA	S	AFG1-like ATPase
MAG.T12.45_02658	55952.BU52_14505	1.4e-14	86.3	Actinobacteria													Bacteria	2EA6A@1,2II4E@201174,334B4@2	NA|NA|NA	S	Domain of unknown function (DUF4439)
MAG.T12.45_02659	1449355.JQNR01000005_gene4681	2e-08	65.9	Actinobacteria													Bacteria	2EUHF@1,2ISV6@201174,33MZK@2	NA|NA|NA		
MAG.T12.45_02660	1245475.ANAE01000075_gene2816	6.1e-40	170.6	Streptosporangiales	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K09748					ko00000,ko03009				Bacteria	2I9BT@201174,4EJF1@85012,COG0779@1,COG0779@2	NA|NA|NA	S	Required for maturation of 30S ribosomal subunits
MAG.T12.45_02661	44060.JODL01000009_gene1920	1.2e-132	479.6	Actinobacteria	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Bacteria	2GJDJ@201174,COG0195@1,COG0195@2	NA|NA|NA	K	Participates in both transcription termination and antitermination
MAG.T12.45_02662	479432.Sros_8386	1.4e-63	250.0	Streptosporangiales													Bacteria	2GM96@201174,4EI1R@85012,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T12.45_02663	211114.JOEF01000026_gene262	1.1e-20	107.8	Pseudonocardiales				ko:K13671					ko00000,ko01000,ko01003		GT87		Bacteria	2GJBC@201174,4DZJI@85010,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_02664	2074.JNYD01000016_gene4254	3.9e-21	109.4	Pseudonocardiales				ko:K13671					ko00000,ko01000,ko01003		GT87		Bacteria	2GJBC@201174,4E0FQ@85010,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_02665	471852.Tcur_2117	1.2e-33	151.0	Streptosporangiales													Bacteria	2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_02666	367299.JOEE01000003_gene2964	7.9e-32	145.2	Intrasporangiaceae													Bacteria	2ICX6@201174,4FF5W@85021,COG1287@1,COG1287@2	NA|NA|NA	S	oligosaccharyl transferase activity
MAG.T12.45_02669	1122609.AUGT01000012_gene4249	6.4e-67	261.2	Propionibacteriales				ko:K12511					ko00000,ko02044				Bacteria	2GK7B@201174,4DR34@85009,COG2064@1,COG2064@2	NA|NA|NA	NU	Type II secretion system
MAG.T12.45_02670	1306174.JODP01000009_gene6554	6.8e-65	254.6	Actinobacteria				ko:K12510					ko00000,ko02044				Bacteria	2H577@201174,COG4965@1,COG4965@2	NA|NA|NA	U	Type ii secretion system
MAG.T12.45_02671	1120936.KB907210_gene5469	1e-207	730.3	Streptosporangiales	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578					ko00000,ko01000				Bacteria	2GIWX@201174,4EGY7@85012,COG1643@1,COG1643@2	NA|NA|NA	L	Helicase associated domain (HA2)  Add an annotation
MAG.T12.45_02673	37919.EP51_31660	4.2e-30	137.9	Nocardiaceae	yqgC			ko:K09793					ko00000				Bacteria	2IQDE@201174,4G1BR@85025,COG2839@1,COG2839@2	NA|NA|NA	S	Protein of unknown function (DUF456)
MAG.T12.45_02674	446468.Ndas_3308	6.3e-10	69.7	Streptosporangiales													Bacteria	2E39Y@1,2GQJA@201174,32Y9G@2,4EKEQ@85012	NA|NA|NA		
MAG.T12.45_02675	469371.Tbis_2394	2e-273	948.3	Pseudonocardiales	gyrB2		5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	2GM1E@201174,4DZQK@85010,COG0187@1,COG0187@2	NA|NA|NA	L	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
MAG.T12.45_02676	479432.Sros_7083	7.4e-52	210.3	Streptosporangiales	cah		4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000				Bacteria	2GM1M@201174,4EIY6@85012,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide
MAG.T12.45_02677	66377.JOBH01000015_gene4135	9.9e-111	406.8	Actinobacteria	yumC	GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281	1.18.1.2,1.19.1.1	ko:K21567					ko00000,ko01000			iYO844.BSU32110	Bacteria	2GJ1Z@201174,COG0492@1,COG0492@2	NA|NA|NA	C	Ferredoxin-NADP reductase
MAG.T12.45_02678	561175.KB894100_gene4794	9.3e-44	184.1	Streptosporangiales				ko:K07058					ko00000				Bacteria	2GM6P@201174,4EIBQ@85012,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T12.45_02679	1033730.CAHG01000012_gene2363	3.7e-11	73.2	Propionibacteriales													Bacteria	2EGJK@1,2GX71@201174,33ABR@2,4DSKZ@85009	NA|NA|NA		
MAG.T12.45_02680	710696.Intca_3501	4e-33	147.1	Intrasporangiaceae				ko:K06218					ko00000,ko02048				Bacteria	2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2	NA|NA|NA	DJ	ParE toxin of type II toxin-antitoxin system, parDE
MAG.T12.45_02681	1385519.N801_09810	4.2e-164	584.3	Intrasporangiaceae													Bacteria	2GS79@201174,4FF88@85021,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase IS116/IS110/IS902 family
MAG.T12.45_02682	710696.Intca_3502	9.2e-30	136.3	Intrasporangiaceae			2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048				Bacteria	2GRC8@201174,4FJ8S@85021,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T12.45_02683	1192034.CAP_7082	4e-43	182.2	Myxococcales	ykfA		3.4.17.13	ko:K01297					ko00000,ko01000,ko01002,ko01011				Bacteria	1MWIY@1224,2WJ3S@28221,2YV3I@29,42Q52@68525,COG1619@1,COG1619@2	NA|NA|NA	V	LD-carboxypeptidase
MAG.T12.45_02684	266940.Krad_0471	6.5e-71	273.9	Actinobacteria	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000				Bacteria	2GPJE@201174,COG0035@1,COG0035@2	NA|NA|NA	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MAG.T12.45_02685	2045.KR76_24730	5e-51	207.2	Propionibacteriales	tadA		3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19	ko:K01485,ko:K01563,ko:K04075,ko:K11991	ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120		R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223	RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	2IM3Z@201174,4DQP2@85009,COG0590@1,COG0590@2	NA|NA|NA	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MAG.T12.45_02686	479433.Caci_8567	5.8e-141	507.7	Actinobacteria	pntB		1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2GNKB@201174,COG1282@1,COG1282@2	NA|NA|NA	C	the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MAG.T12.45_02687	1120960.ATXG01000003_gene2102	3.4e-25	120.9	Microbacteriaceae	pntAB		1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2IKR9@201174,4FPHA@85023,COG3288@1,COG3288@2	NA|NA|NA	C	4TM region of pyridine nucleotide transhydrogenase, mitoch
MAG.T12.45_02688	351607.Acel_2022	1.9e-103	382.9	Frankiales	pntAA		1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2I2FZ@201174,4ERQN@85013,COG3288@1,COG3288@2	NA|NA|NA	C	PFAM alanine dehydrogenase PNT domain protein
MAG.T12.45_02689	1449058.JQKT01000009_gene122	1.5e-75	290.0	Bacteria			5.5.1.24	ko:K09834	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07502,R07503,R10623,R10624	RC01911	ko00000,ko00001,ko00002,ko01000				Bacteria	2Z7HP@2,arCOG12964@1	NA|NA|NA	S	Tocopherol cyclase
MAG.T12.45_02690	471852.Tcur_4029	6.1e-19	99.8	Streptosporangiales			2.7.1.193	ko:K02803	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7			Bacteria	2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2	NA|NA|NA	G	phosphotransferase system, EIIB
MAG.T12.45_02691	44060.JODL01000022_gene5029	2.9e-33	148.3	Actinobacteria	crr		2.7.1.193,2.7.1.199	ko:K02777,ko:K02802,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.2,4.A.1.1.9			Bacteria	2GK6B@201174,COG2190@1,COG2190@2	NA|NA|NA	G	Pts system
MAG.T12.45_02692	1292373.H640_07474	2.5e-16	91.3	Actinobacteria	ptsH			ko:K03488,ko:K11189					ko00000,ko02000,ko03000	4.A.2.1			Bacteria	2GQX6@201174,COG1925@1,COG1925@2	NA|NA|NA	G	phosphocarrier protein hpr
MAG.T12.45_02693	570268.ANBB01000035_gene2253	2.3e-168	599.0	Streptosporangiales	ptsI		2.7.3.9	ko:K08483	ko02060,map02060				ko00000,ko00001,ko01000,ko02000	8.A.7			Bacteria	2GIZZ@201174,4EGVU@85012,COG1080@1,COG1080@2	NA|NA|NA	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MAG.T12.45_02696	58123.JOFJ01000001_gene3034	4.1e-66	258.1	Streptosporangiales	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363		ko:K06997					ko00000				Bacteria	2GMRJ@201174,4EGGM@85012,COG0325@1,COG0325@2	NA|NA|NA	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MAG.T12.45_02697	882083.SacmaDRAFT_3694	1.9e-48	199.5	Pseudonocardiales	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944		ko:K05810					ko00000,ko01000				Bacteria	2GN1M@201174,4DZFD@85010,COG1496@1,COG1496@2	NA|NA|NA	S	Belongs to the multicopper oxidase YfiH RL5 family
MAG.T12.45_02698	68223.JNZY01000002_gene5187	1e-154	553.1	Actinobacteria	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03531	ko04112,map04112				ko00000,ko00001,ko02048,ko03036,ko04812				Bacteria	2GJWC@201174,COG0206@1,COG0206@2	NA|NA|NA	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MAG.T12.45_02699	446462.Amir_5761	3.2e-24	119.0	Pseudonocardiales	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036				Bacteria	2H4A4@201174,4E3DB@85010,COG1589@1,COG1589@2	NA|NA|NA	D	Cell division protein FtsQ
MAG.T12.45_02700	1048339.KB913029_gene4575	2.1e-138	499.2	Frankiales	murC	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100		R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2I2E7@201174,4ERUC@85013,COG0773@1,COG0773@2	NA|NA|NA	M	Belongs to the MurCDEF family
MAG.T12.45_02701	1288083.AUKR01000001_gene1241	6.3e-119	434.1	Actinobacteria	murG		2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112		R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011		GT28	iLJ478.TM0232	Bacteria	2GJEM@201174,COG0707@1,COG0707@2	NA|NA|NA	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAG.T12.45_02702	1120950.KB892707_gene4889	2.9e-91	342.4	Propionibacteriales	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28		Bacteria	2GKXP@201174,4DNHR@85009,COG0772@1,COG0772@2	NA|NA|NA	D	Belongs to the SEDS family
MAG.T12.45_02703	1048339.KB913029_gene4578	1.3e-148	533.1	Frankiales	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100		R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iNJ661.Rv2155c	Bacteria	2GJZA@201174,4ERI0@85013,COG0771@1,COG0771@2	NA|NA|NA	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAG.T12.45_02704	1504319.GM45_1105	4.5e-117	427.9	unclassified Actinobacteria (class)	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502		R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146		iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Bacteria	2GNEH@201174,3UWA7@52018,COG0472@1,COG0472@2	NA|NA|NA	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAG.T12.45_02705	146922.JOFU01000006_gene2820	3.6e-135	488.4	Actinobacteria	murF		6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502		R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2GK0Y@201174,COG0770@1,COG0770@2	NA|NA|NA	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MAG.T12.45_02706	1120950.KB892707_gene4885	5.2e-143	514.6	Propionibacteriales	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.10,6.3.2.13	ko:K01928,ko:K15792	ko00300,ko00550,map00300,map00550		R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011			iNJ661.Rv2158c	Bacteria	2GIS2@201174,4DN64@85009,COG0769@1,COG0769@2	NA|NA|NA	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MAG.T12.45_02707	1504319.GM45_1090	1.4e-139	503.4	unclassified Actinobacteria (class)	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01011,ko03036			iSSON_1240.SSON_0092	Bacteria	2GKHH@201174,3UWG5@52018,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin-binding Protein dimerisation domain
MAG.T12.45_02708	479435.Kfla_2879	3.2e-14	85.9	Propionibacteriales	ftsL			ko:K05589,ko:K12065					ko00000,ko02044,ko03036	3.A.7.11.1			Bacteria	2GW5Q@201174,4DS2Z@85009,COG2919@1,COG2919@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MAG.T12.45_02709	65497.JODV01000002_gene4329	2.2e-107	395.6	Pseudonocardiales	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438					ko00000,ko01000,ko03009				Bacteria	2GJGK@201174,4DZ61@85010,COG0275@1,COG0275@2	NA|NA|NA	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MAG.T12.45_02711	1504319.GM45_1075	2.9e-43	181.4	unclassified Actinobacteria (class)	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K03925					ko00000				Bacteria	2IHUB@201174,3UWSJ@52018,COG2001@1,COG2001@2	NA|NA|NA	K	MraZ protein, putative antitoxin-like
MAG.T12.45_02712	1206726.BAFV01000053_gene3823	3.1e-09	67.0	Nocardiaceae													Bacteria	2IGCQ@201174,4FYK2@85025,COG2030@1,COG2030@2	NA|NA|NA	I	MaoC like domain
MAG.T12.45_02713	1449353.JQMQ01000005_gene4313	9.6e-32	142.5	Streptacidiphilus	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03596	ko05134,map05134				ko00000,ko00001				Bacteria	2GJAB@201174,2NECG@228398,COG0481@1,COG0481@2	NA|NA|NA	M	GTP-binding protein LepA C-terminus
MAG.T12.45_02714	1869.MB27_31595	1.9e-98	365.9	Micromonosporales	f42a												Bacteria	2GM0Z@201174,4DBBQ@85008,COG0330@1,COG0330@2	NA|NA|NA	O	prohibitin homologues
MAG.T12.45_02715	1435356.Y013_20760	3.3e-19	100.9	Nocardiaceae													Bacteria	2GQV1@201174,4G3V1@85025,COG4877@1,COG4877@2	NA|NA|NA		
MAG.T12.45_02716	1123251.ATWM01000011_gene2708	1.5e-28	131.7	Intrasporangiaceae													Bacteria	2GKW1@201174,4FEGQ@85021,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
MAG.T12.45_02718	1217658.F987_02722	8.4e-16	91.7	Moraxellaceae													Bacteria	1QVSC@1224,1SRBM@1236,3NR5W@468,COG3979@1,COG3979@2	NA|NA|NA	S	chitinase
MAG.T12.45_02719	710111.FraQA3DRAFT_3461	7e-25	120.6	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IKVM@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_02721	1123052.AUDF01000002_gene687	1.3e-21	109.8	Microbacteriaceae													Bacteria	2B212@1,2HTBX@201174,31UHT@2,4FSXA@85023	NA|NA|NA		
MAG.T12.45_02722	1380370.JIBA01000011_gene3047	7.7e-150	536.6	Intrasporangiaceae				ko:K04763					ko00000,ko03036				Bacteria	2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_02723	1123251.ATWM01000007_gene2333	1.1e-27	129.4	Intrasporangiaceae													Bacteria	2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021	NA|NA|NA	S	Ribbon-helix-helix protein, copG family
MAG.T12.45_02724	1429046.RR21198_1564	1.7e-24	118.2	Nocardiaceae													Bacteria	2BGV5@1,2HM66@201174,32AUV@2,4G51E@85025	NA|NA|NA		
MAG.T12.45_02728	1123309.AQYB01000031_gene361	3.7e-19	100.9	Bacilli	pspE												Bacteria	1VES3@1239,4HNRE@91061,COG0607@1,COG0607@2	NA|NA|NA	P	COG0607 Rhodanese-related sulfurtransferase
MAG.T12.45_02729	55952.BU52_25740	1.6e-133	483.0	Actinobacteria			3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000				Bacteria	2GN50@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2	NA|NA|NA	P	PFAM beta-lactamase domain protein
MAG.T12.45_02730	1064537.AGSO01000003_gene1096	8.1e-29	134.4	Dermabacteraceae				ko:K07090					ko00000				Bacteria	2I5VT@201174,4FCQ5@85020,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T12.45_02731	446469.Sked_03560	1.4e-118	433.3	Actinobacteria	phoA		3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147				Bacteria	2GM8A@201174,COG1785@1,COG1785@2	NA|NA|NA	P	Belongs to the alkaline phosphatase family
MAG.T12.45_02732	1035308.AQYY01000002_gene111	1.7e-58	233.4	Peptococcaceae													Bacteria	1V0ES@1239,24Q6Z@186801,26717@186807,COG1275@1,COG1275@2	NA|NA|NA	P	Voltage-dependent anion channel
MAG.T12.45_02733	1051632.TPY_2536	1.7e-22	112.1	Firmicutes													Bacteria	1W45F@1239,COG1433@1,COG1433@2	NA|NA|NA	S	Dinitrogenase iron-molybdenum cofactor
MAG.T12.45_02734	1304865.JAGF01000001_gene3278	0.0	1120.1	Cellulomonadaceae	cdr			ko:K04085	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	2H7WY@201174,4F10M@85016,COG0446@1,COG0446@2,COG0607@1,COG0607@2,COG2210@1,COG2210@2	NA|NA|NA	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_02735	1035308.AQYY01000001_gene3237	1.1e-195	689.5	Clostridia			1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	1V11U@1239,25BW0@186801,COG0446@1,COG0446@2	NA|NA|NA	S	Pyridine nucleotide-disulphide oxidoreductase
MAG.T12.45_02737	1035308.AQYY01000002_gene879	1.6e-74	285.8	Clostridia													Bacteria	1TS81@1239,248XH@186801,COG0745@1,COG0745@2	NA|NA|NA	T	response regulator receiver
MAG.T12.45_02738	1035308.AQYY01000002_gene880	9.2e-83	314.3	Clostridia			2.7.13.3	ko:K02484,ko:K07768	ko02020,map02020	M00443			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1TQ1H@1239,247VG@186801,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
MAG.T12.45_02739	1906.SFRA_16445	3.4e-25	122.1	Actinobacteria			2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	2IKIN@201174,COG4902@1,COG4902@2	NA|NA|NA	S	Uncharacterized protein domain (DUF2202)
MAG.T12.45_02740	313589.JNB_07719	9.1e-94	350.1	Intrasporangiaceae	fmt2		3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	2GKJH@201174,4FEFV@85021,COG1611@1,COG1611@2	NA|NA|NA	S	Belongs to the LOG family
MAG.T12.45_02741	1404245.CGLY_03165	7.4e-29	134.0	Corynebacteriaceae													Bacteria	22JPX@1653,2GKFS@201174,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MAG.T12.45_02742	1123320.KB889686_gene650	1.3e-36	159.5	Actinobacteria	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120		R01016	RC00424	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992	Bacteria	2IMPC@201174,COG1803@1,COG1803@2	NA|NA|NA	G	MGS-like domain
MAG.T12.45_02743	196162.Noca_1247	9.6e-238	829.3	Propionibacteriales	oadA		2.1.3.1,4.1.1.3,6.4.1.1	ko:K01571,ko:K01960,ko:K03416	ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344,R00353,R00930	RC00040,RC00097,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1		iLJ478.TM0128	Bacteria	2IASR@201174,4DWP1@85009,COG5016@1,COG5016@2	NA|NA|NA	C	Conserved carboxylase domain
MAG.T12.45_02744	196162.Noca_1248	1.1e-236	825.9	Propionibacteriales	mmdA		2.1.3.1,2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01966,ko:K01969,ko:K17489,ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00373,M00741	R00353,R00742,R01859,R04138,R04386	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0716	Bacteria	2GIRU@201174,4DU79@85009,COG4799@1,COG4799@2	NA|NA|NA	I	Malonate decarboxylase gamma subunit (MdcE)
MAG.T12.45_02745	196162.Noca_1249	3.6e-15	87.4	Propionibacteriales			2.1.3.1	ko:K17489	ko00640,map00640		R00353	RC00040	ko00000,ko00001,ko01000				Bacteria	2EJZC@1,2GYHI@201174,33DPX@2,4DW75@85009	NA|NA|NA		
MAG.T12.45_02746	196162.Noca_1250	2.9e-18	98.2	Propionibacteriales	pccA		2.1.3.1,6.4.1.3	ko:K01965,ko:K17490	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GPU3@201174,4DVQ9@85009,COG4770@1,COG4770@2	NA|NA|NA	I	Biotin-lipoyl like
MAG.T12.45_02747	1184609.KILIM_066_00310	3.6e-81	307.8	Dermatophilaceae													Bacteria	2GY1D@201174,4F7U4@85018,COG0454@1,COG0456@2	NA|NA|NA	K	Acetyltransferase (GNAT) family
MAG.T12.45_02749	350058.Mvan_3810	4.7e-310	1070.5	Mycobacteriaceae	pacL2		3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2			Bacteria	232MQ@1762,2GJJC@201174,COG0474@1,COG0474@2	NA|NA|NA	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC
MAG.T12.45_02750	1463887.KL589971_gene4547	2.5e-15	88.2	Actinobacteria	ycgR			ko:K07089					ko00000				Bacteria	2GJQ0@201174,COG0701@1,COG0701@2	NA|NA|NA	P	permease
MAG.T12.45_02751	1463881.KL591026_gene2615	3.9e-63	248.1	Actinobacteria	ycgR			ko:K07089					ko00000				Bacteria	2GJQ0@201174,COG0701@1,COG0701@2	NA|NA|NA	P	permease
MAG.T12.45_02752	749414.SBI_01457	4.3e-37	161.8	Actinobacteria	ycgQ			ko:K08986					ko00000				Bacteria	2GZEU@201174,COG3689@1,COG3689@2	NA|NA|NA	S	TIGRFAM TIGR03943 family protein
MAG.T12.45_02753	471852.Tcur_2987	1.8e-117	429.5	Streptosporangiales			1.11.1.19	ko:K15733					ko00000,ko01000				Bacteria	2GIUB@201174,4EICS@85012,COG2837@1,COG2837@2	NA|NA|NA	P	Dyp-type peroxidase family
MAG.T12.45_02754	1283283.ATXA01000001_gene544	8e-35	153.7	Frankiales													Bacteria	2IN6K@201174,4ETDQ@85013,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T12.45_02756	357809.Cphy_2216	7.3e-23	114.8	Lachnoclostridium				ko:K07452,ko:K09384					ko00000,ko01000,ko02048				Bacteria	1U8TV@1239,223CF@1506553,258B5@186801,COG0470@1,COG0470@2	NA|NA|NA	L	DNA polymerase III
MAG.T12.45_02758	1380393.JHVP01000006_gene4003	6.3e-126	457.6	Frankiales				ko:K03088					ko00000,ko03021				Bacteria	2GJ36@201174,4ES50@85013,COG4941@1,COG4941@2	NA|NA|NA	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family
MAG.T12.45_02759	287986.DV20_29020	6.4e-23	113.6	Pseudonocardiales													Bacteria	2IKRD@201174,4E51J@85010,COG3795@1,COG3795@2	NA|NA|NA	S	YCII-related domain
MAG.T12.45_02760	1304865.JAGF01000001_gene1494	2.3e-33	148.3	Actinobacteria													Bacteria	2IKRD@201174,COG3795@1,COG3795@2	NA|NA|NA	S	PFAM YCII-related
MAG.T12.45_02761	1380354.JIAN01000006_gene1134	1.7e-117	430.3	Actinobacteria													Bacteria	2IF8Q@201174,COG1287@1,COG1287@2	NA|NA|NA	S	oligosaccharyl transferase activity
MAG.T12.45_02762	469383.Cwoe_3710	4.6e-84	318.2	Rubrobacteria													Bacteria	2I2PK@201174,4CPE1@84995,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T12.45_02763	909613.UO65_4713	1.3e-33	150.6	Pseudonocardiales	mprF			ko:K07027					ko00000,ko02000	4.D.2			Bacteria	2IC25@201174,4E1XV@85010,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
MAG.T12.45_02764	1095767.CAHD01000163_gene3000	5.2e-48	198.0	Actinobacteria													Bacteria	2INQ3@201174,COG4122@1,COG4122@2	NA|NA|NA	S	Methyltransferase domain
MAG.T12.45_02765	1121382.JQKG01000029_gene2690	3.3e-58	231.9	Bacteria			1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1091@1,COG1091@2	NA|NA|NA	M	dTDP-4-dehydrorhamnose reductase activity
MAG.T12.45_02766	1172185.KB911513_gene4762	6.1e-48	197.2	Nocardiaceae				ko:K21429					ko00000,ko01002				Bacteria	2GKWI@201174,4G7P5@85025,COG4894@1,COG4894@2	NA|NA|NA	S	LURP-one-related
MAG.T12.45_02767	196162.Noca_0300	1.6e-31	142.1	Propionibacteriales													Bacteria	2IKJX@201174,32SQA@2,4DR6N@85009,COG5450@1	NA|NA|NA	K	Transcription regulator of the Arc MetJ class
MAG.T12.45_02768	263358.VAB18032_21750	1.9e-25	123.6	Actinobacteria													Bacteria	2GRFR@201174,COG3409@1,COG3409@2	NA|NA|NA	M	PFAM Peptidoglycan-binding domain 1 protein
MAG.T12.45_02771	382245.ASA_0486	9e-51	206.8	Aeromonadales	maa		2.3.1.79	ko:K00661					ko00000,ko01000				Bacteria	1RA2T@1224,1S3ZZ@1236,1Y4GY@135624,COG0110@1,COG0110@2	NA|NA|NA	S	Maltose acetyltransferase
MAG.T12.45_02773	105422.BBPM01000049_gene1445	9.5e-69	267.3	Streptacidiphilus	apbE		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	2H74Y@201174,2NGV9@228398,COG1477@1,COG1477@2	NA|NA|NA	H	ApbE family
MAG.T12.45_02774	106370.Francci3_2586	1e-42	180.3	Frankiales				ko:K17247					ko00000				Bacteria	2GQH2@201174,4EW08@85013,COG4097@1,COG4097@2	NA|NA|NA	P	PFAM Ferric reductase domain protein transmembrane component domain
MAG.T12.45_02775	436229.JOEH01000022_gene682	5.9e-111	407.9	Streptacidiphilus	nuoF2		1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GNN9@201174,2NGPM@228398,COG1894@1,COG1894@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
MAG.T12.45_02776	235985.BBPN01000004_gene3111	5.5e-16	89.7	Streptacidiphilus				ko:K05337					ko00000				Bacteria	2GSJ7@201174,2NJW1@228398,COG1141@1,COG1141@2	NA|NA|NA	C	4Fe-4S single cluster domain
MAG.T12.45_02777	1048339.KB913029_gene2698	4.1e-93	347.8	Frankiales													Bacteria	2GIZB@201174,4ERW3@85013,COG0745@1,COG0745@2	NA|NA|NA	T	response regulator
MAG.T12.45_02778	1003195.SCAT_5254	3.5e-107	395.6	Actinobacteria													Bacteria	2GIV9@201174,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T12.45_02779	1121934.AUDX01000004_gene2657	4.8e-36	157.9	Microbacteriaceae													Bacteria	2GX8K@201174,4FQPR@85023,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_02780	1304865.JAGF01000001_gene318	7.4e-172	610.5	Cellulomonadaceae													Bacteria	2GIUM@201174,4F1U8@85016,COG0477@1,COG0477@2	NA|NA|NA	EGP	Transmembrane secretion effector
MAG.T12.45_02781	1121272.KB903290_gene4656	2.4e-60	238.8	Micromonosporales	aceF		2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GN5J@201174,4DIEJ@85008,COG0508@1,COG0508@2	NA|NA|NA	C	e3 binding domain
MAG.T12.45_02782	1123020.AUIE01000023_gene5023	9.2e-10	69.3	Bacteria													Bacteria	COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAG.T12.45_02784	452652.KSE_07440	1.2e-25	124.4	Actinobacteria			2.1.1.107	ko:K02303,ko:K22010	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121,M00839	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000,ko02022				Bacteria	2GKG3@201174,COG2203@1,COG2203@2,COG2208@1,COG2208@2,COG3707@1,COG3707@2	NA|NA|NA	KT	phosphatase
MAG.T12.45_02786	404589.Anae109_3092	6.4e-17	95.9	Proteobacteria													Bacteria	1N29G@1224,COG3568@1,COG3568@2	NA|NA|NA	S	Endonuclease/Exonuclease/phosphatase family
MAG.T12.45_02787	1121920.AUAU01000018_gene1775	4e-17	94.7	Acidobacteria													Bacteria	3Y4HW@57723,COG2318@1,COG2318@2	NA|NA|NA	S	Mycothiol maleylpyruvate isomerase N-terminal domain
MAG.T12.45_02788	471852.Tcur_4438	8.1e-163	580.5	Streptosporangiales	hemD	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJZ@201174,4EFW8@85012,COG0007@1,COG0007@2,COG1587@1,COG1587@2	NA|NA|NA	H	Uroporphyrinogen-III synthase HemD
MAG.T12.45_02789	996637.SGM_1352	3.2e-74	285.4	Actinobacteria	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMWI@201174,COG0181@1,COG0181@2	NA|NA|NA	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
MAG.T12.45_02790	1211815.CBYP010000047_gene1633	1.1e-96	360.5	Frankiales	hemA	GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492	ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000,ko02035			iSB619.SA_RS08420	Bacteria	2GJRA@201174,4ERHS@85013,COG0373@1,COG0373@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MAG.T12.45_02791	1894.JOER01000011_gene2071	4.1e-81	307.8	Actinobacteria													Bacteria	2GK4B@201174,COG2197@1,COG2197@2	NA|NA|NA	T	response regulator
MAG.T12.45_02792	1380390.JIAT01000017_gene5376	2.5e-64	252.7	Rubrobacteria	iolTA			ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GKIJ@201174,4CQ39@84995,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T12.45_02794	105420.BBPO01000125_gene4715	2.9e-15	87.8	Streptacidiphilus													Bacteria	2BVHC@1,2IN31@201174,2NMD9@228398,32QVY@2	NA|NA|NA		
MAG.T12.45_02796	1048339.KB913029_gene3508	5.8e-210	737.6	Frankiales	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044464,GO:0045893,GO:0045935,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070566,GO:0070569,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0090293,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89	ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018	M00017,M00018	R00243,R01773,R01775,R09382,R09383,R09384,R09386	RC00006,RC00078,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Bacteria	2GMKT@201174,4ERG2@85013,COG2844@1,COG2844@2	NA|NA|NA	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MAG.T12.45_02797	1449353.JQMQ01000005_gene2028	1.7e-46	191.8	Streptacidiphilus	glnB			ko:K04751	ko02020,map02020				ko00000,ko00001				Bacteria	2IKN1@201174,2NIJK@228398,COG0347@1,COG0347@2	NA|NA|NA	E	Nitrogen regulatory protein P-II
MAG.T12.45_02798	1306174.JODP01000016_gene7106	1.3e-159	569.7	Actinobacteria	amt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03320					ko00000,ko02000	1.A.11		iNJ661.Rv2920c	Bacteria	2GIZK@201174,COG0004@1,COG0004@2	NA|NA|NA	P	Ammonium transporter
MAG.T12.45_02799	591167.Sfla_1718	8.6e-124	450.3	Actinobacteria	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7			Bacteria	2GJQH@201174,COG0552@1,COG0552@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MAG.T12.45_02800	1298863.AUEP01000002_gene1371	0.0	1125.9	Propionibacteriales	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03529,ko:K19171					ko00000,ko02048,ko03036				Bacteria	2GK93@201174,4DN2T@85009,COG1196@1,COG1196@2	NA|NA|NA	D	Required for chromosome condensation and partitioning
MAG.T12.45_02802	479431.Namu_1888	2.5e-17	94.7	Frankiales	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120		R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000			iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Bacteria	2IQ4M@201174,4ETFK@85013,COG1254@1,COG1254@2	NA|NA|NA	C	Belongs to the acylphosphatase family
MAG.T12.45_02803	471853.Bcav_1610	1.1e-25	122.5	Actinobacteria	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJNT@201174,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MAG.T12.45_02804	1048339.KB913029_gene3420	1.7e-49	202.2	Frankiales	mce		5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000				Bacteria	2IIPR@201174,4ESUP@85013,COG0346@1,COG0346@2	NA|NA|NA	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase
MAG.T12.45_02805	345341.KUTG_06459	2.4e-167	595.1	Pseudonocardiales	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJAC@201174,4DYM7@85010,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T12.45_02806	1894.JOER01000007_gene6468	5.8e-108	397.5	Actinobacteria				ko:K07588					ko00000,ko01000				Bacteria	2GME8@201174,COG1703@1,COG1703@2	NA|NA|NA	E	LAO AO transport system ATPase
MAG.T12.45_02808	1120936.KB907216_gene3853	1.7e-206	725.7	Streptosporangiales	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	Bacteria	2GIU6@201174,4EHHS@85012,COG0508@1,COG0508@2,COG0567@1,COG0567@2	NA|NA|NA	C	2-oxoglutarate dehydrogenase C-terminal
MAG.T12.45_02809	1122622.ATWJ01000012_gene997	3.7e-18	96.7	Intrasporangiaceae													Bacteria	2E460@1,2GQGS@201174,32Z20@2,4FHQE@85021	NA|NA|NA		
MAG.T12.45_02810	1123322.KB904735_gene1568	5.5e-100	371.3	Actinobacteria	patB		4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230		R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007				Bacteria	2GJFQ@201174,COG1168@1,COG1168@2	NA|NA|NA	E	Aminotransferase, class I
MAG.T12.45_02811	1463856.JOHY01000003_gene5078	5.2e-22	111.7	Actinobacteria													Bacteria	2GS51@201174,COG2138@1,COG2138@2	NA|NA|NA	P	cobalamin (vitamin B12) biosynthesis CbiX protein
MAG.T12.45_02812	1713.JOFV01000005_gene2127	2.7e-105	389.0	Cellulomonadaceae	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.79,1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303,ko:K02304,ko:K04719	ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947,R09083	RC00003,RC00435,RC00871,RC01012,RC01034,RC02413	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	Bacteria	2GK3B@201174,4F0HX@85016,COG0007@1,COG0007@2	NA|NA|NA	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase
MAG.T12.45_02813	446462.Amir_1235	1.5e-148	532.7	Pseudonocardiales	cysN		2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJDX@201174,4DYZW@85010,COG2895@1,COG2895@2	NA|NA|NA	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
MAG.T12.45_02814	1223523.H340_21731	2.2e-109	401.7	Actinobacteria	cysD		1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN85@201174,COG0175@1,COG0175@2	NA|NA|NA	EH	sulfate adenylyltransferase
MAG.T12.45_02815	1463934.JOCF01000059_gene3339	1.3e-59	236.5	Actinobacteria	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000				Bacteria	2GNKC@201174,COG1694@1,COG3956@2	NA|NA|NA	S	PFAM MazG nucleotide pyrophosphohydrolase
MAG.T12.45_02817	1907.SGLAU_14165	0.0	1522.7	Actinobacteria	mfd			ko:K03723	ko03420,map03420				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJ42@201174,COG1197@1,COG1197@2	NA|NA|NA	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MAG.T12.45_02818	1123393.KB891316_gene1793	3.7e-143	515.8	Betaproteobacteria													Bacteria	1MU2C@1224,2VH3V@28216,COG5001@1,COG5001@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T12.45_02819	350058.Mvan_3479	8e-41	174.1	Mycobacteriaceae	cysQ	GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008934,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019637,GO:0019693,GO:0030145,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050308,GO:0050427,GO:0050897,GO:0052745,GO:0052834,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130		R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016				Bacteria	232H4@1762,2GMW7@201174,COG1218@1,COG1218@2	NA|NA|NA	P	Inositol monophosphatase
MAG.T12.45_02820	1463934.JOCF01000115_gene7689	4.7e-50	204.1	Actinobacteria				ko:K16786,ko:K16787	ko02010,map02010	M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2I2Y2@201174,COG3845@1,COG3845@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
MAG.T12.45_02821	1463864.JOGO01000009_gene499	3.8e-66	258.5	Actinobacteria				ko:K02006,ko:K16784,ko:K16786,ko:K16787,ko:K16927	ko02010,map02010	M00245,M00246,M00581,M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2GMK1@201174,COG1122@1,COG1122@2	NA|NA|NA	P	ECF transporter, substrate-specific component
MAG.T12.45_02822	1078020.KEK_15608	1.2e-98	367.1	Mycobacteriaceae	cobU		2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000				Bacteria	23984@1762,2GM8Q@201174,COG1235@1,COG1235@2,COG2087@1,COG2087@2	NA|NA|NA	H	cobinamide kinase
MAG.T12.45_02823	446462.Amir_1358	8.7e-100	370.5	Pseudonocardiales	cobT		2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2207	Bacteria	2GJ16@201174,4DX78@85010,COG2038@1,COG2038@2	NA|NA|NA	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
MAG.T12.45_02824	469371.Tbis_1275	3.1e-35	155.6	Pseudonocardiales	cobS	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKM4@201174,4E2M6@85010,COG0368@1,COG0368@2	NA|NA|NA	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MAG.T12.45_02825	2074.JNYD01000003_gene3655	1.8e-107	396.0	Pseudonocardiales	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ47@201174,4DXZ6@85010,COG0404@1,COG0404@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine
MAG.T12.45_02826	266940.Krad_3276	1.3e-127	463.4	Actinobacteria	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJRB@201174,COG0260@1,COG0260@2	NA|NA|NA	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MAG.T12.45_02827	326424.FRAAL5456	5.8e-76	291.6	Frankiales				ko:K14059					ko00000				Bacteria	2GMMI@201174,4ESQP@85013,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_02829	1463857.JOFZ01000004_gene2532	1.8e-147	528.9	Actinobacteria	gcvP	GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016642,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3318	Bacteria	2GJ11@201174,COG0403@1,COG0403@2,COG1003@1,COG1003@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAG.T12.45_02830	44060.JODL01000004_gene2457	3.6e-38	164.9	Actinobacteria													Bacteria	2IFC7@201174,COG5083@1,COG5083@2	NA|NA|NA	S	phosphatidylinositol transporter activity
MAG.T12.45_02831	711393.AYRX01000031_gene269	1e-38	166.4	Actinobacteria													Bacteria	2IFBJ@201174,COG2050@1,COG2050@2	NA|NA|NA	Q	Domain of unknown function (DUF4442)
MAG.T12.45_02832	479433.Caci_2340	3.1e-184	651.4	Actinobacteria	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944		ko:K02355					ko00000,ko03012,ko03029				Bacteria	2GKRU@201174,COG0480@1,COG0480@2	NA|NA|NA	J	elongation factor G
MAG.T12.45_02833	1463901.JOIY01000048_gene2438	4.8e-49	200.7	Actinobacteria	gpsA		1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110		R00842,R00844	RC00029	ko00000,ko00001,ko01000				Bacteria	2GJSD@201174,COG0240@1,COG0240@2	NA|NA|NA	I	Glycerol-3-phosphate dehydrogenase
MAG.T12.45_02834	397278.JOJN01000003_gene1964	2.6e-52	212.2	Propionibacteriales													Bacteria	2I655@201174,4DSYQ@85009,COG3064@1,COG3064@2	NA|NA|NA	M	Membrane
MAG.T12.45_02835	1120950.KB892741_gene2699	1e-103	383.6	Propionibacteriales	metB		2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMD8@201174,4DPBS@85009,COG0626@1,COG0626@2	NA|NA|NA	E	Cys/Met metabolism PLP-dependent enzyme
MAG.T12.45_02836	1048339.KB913029_gene3486	1.4e-121	443.0	Frankiales	ddl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008716,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464,GO:0050896	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Bacteria	2GITC@201174,4ERWT@85013,COG1181@1,COG1181@2	NA|NA|NA	M	Belongs to the D-alanine--D-alanine ligase family
MAG.T12.45_02837	1120950.KB892707_gene4586	3.7e-212	744.6	Propionibacteriales			3.4.19.1	ko:K01303					ko00000,ko01000,ko01002				Bacteria	2GJW4@201174,4DTZJ@85009,COG1506@1,COG1506@2	NA|NA|NA	E	Dienelactone hydrolase family
MAG.T12.45_02838	1229780.BN381_60056	8.1e-31	140.6	Actinobacteria	rimJ2												Bacteria	2IS6V@201174,COG1670@1,COG1670@2	NA|NA|NA	J	Acetyltransferase (GNAT) domain
MAG.T12.45_02839	1120950.KB892741_gene2701	2.7e-18	98.6	Propionibacteriales													Bacteria	2CQFE@1,2GRVK@201174,32SM3@2,4DS6W@85009	NA|NA|NA	S	Protein of unknown function (DUF3515)
MAG.T12.45_02840	471857.Svir_09180	4.8e-24	116.7	Pseudonocardiales													Bacteria	2IQ4Z@201174,4E5C4@85010,COG1522@1,COG1522@2	NA|NA|NA	K	AsnC family
MAG.T12.45_02841	1463887.KL589967_gene6542	3.3e-90	338.6	Actinobacteria	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2977c,iYO844.BSU05900	Bacteria	2GP6E@201174,COG0611@1,COG0611@2	NA|NA|NA	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MAG.T12.45_02842	446471.Xcel_2281	4.9e-27	126.3	Promicromonosporaceae	rpmB	GO:0003674,GO:0003735,GO:0005198		ko:K02902	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQNU@201174,4F4SP@85017,COG0227@1,COG0227@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL28 family
MAG.T12.45_02843	1123320.KB889676_gene2888	1.1e-109	404.1	Actinobacteria	dak3		2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K07030	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01059	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKII@201174,COG1461@1,COG1461@2	NA|NA|NA	S	Dihydroxyacetone kinase
MAG.T12.45_02844	1123322.KB904683_gene4838	3.9e-224	784.6	Actinobacteria	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKA3@201174,COG1200@1,COG1200@2	NA|NA|NA	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MAG.T12.45_02845	1033730.CAHG01000016_gene241	4.3e-42	177.9	Propionibacteriales	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	2GQ3G@201174,4DQZ1@85009,COG0742@1,COG0742@2	NA|NA|NA	L	Conserved hypothetical protein 95
MAG.T12.45_02846	414996.IL38_09650	9.5e-59	233.0	Actinopolysporales	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN1S@201174,407G2@622450,COG0669@1,COG0669@2	NA|NA|NA	H	Cytidylyltransferase-like
MAG.T12.45_02847	557599.MKAN_02490	1.2e-57	229.6	Mycobacteriaceae				ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	236NP@1762,2IBD6@201174,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_02849	1120944.JONS01000036_gene2549	1.1e-20	105.9	Actinobacteria													Bacteria	2GJV7@201174,4D5Q7@85005,COG1609@1,COG1609@2	NA|NA|NA	K	Periplasmic binding protein domain
MAG.T12.45_02851	1123229.AUBC01000025_gene4510	1.8e-19	102.1	Bradyrhizobiaceae													Bacteria	1RJ9E@1224,2AF64@1,2U9GE@28211,3154Z@2,3K5A6@41294	NA|NA|NA	S	Protein of unknown function (DUF2384)
MAG.T12.45_02853	1240349.ANGC01000009_gene2758	2.7e-70	272.3	Actinobacteria													Bacteria	2ICPM@201174,COG0589@1,COG0589@2	NA|NA|NA	T	universal stress protein
MAG.T12.45_02854	1122149.BACN01000019_gene712	1.7e-07	63.2	Lactobacillaceae	greA			ko:K03624,ko:K04760					ko00000,ko03021				Bacteria	1V1G3@1239,3F6ZK@33958,4HW8H@91061,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MAG.T12.45_02855	644283.Micau_2658	4.6e-128	464.5	Micromonosporales													Bacteria	2GRBZ@201174,4DH16@85008,COG3835@1,COG3835@2	NA|NA|NA	KT	PucR C-terminal helix-turn-helix domain
MAG.T12.45_02856	548479.HMPREF0573_10529	2.6e-08	65.5	Actinobacteria			3.6.3.17	ko:K10441	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJDV@201174,4D5BM@85005,COG1129@1,COG1129@2	NA|NA|NA	G	ATPases associated with a variety of cellular activities
MAG.T12.45_02857	710696.Intca_1166	1.5e-100	372.9	Actinobacteria			2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GP1C@201174,COG0524@1,COG0524@2	NA|NA|NA	G	Belongs to the carbohydrate kinase PfkB family
MAG.T12.45_02858	710696.Intca_1165	6.4e-112	410.6	Intrasporangiaceae	psuG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	4.2.1.70	ko:K16329	ko00240,map00240		R01055	RC00432,RC00433	ko00000,ko00001,ko01000				Bacteria	2GK19@201174,4FEJH@85021,COG2313@1,COG2313@2	NA|NA|NA	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway
MAG.T12.45_02859	710696.Intca_1164	3.4e-65	255.4	Bacteria													Bacteria	COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
MAG.T12.45_02861	1095769.CAHF01000025_gene693	2.1e-204	718.4	Oxalobacteraceae	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MUMF@1224,2VIZ7@28216,472NR@75682,COG0334@1,COG0334@2	NA|NA|NA	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
MAG.T12.45_02862	1232410.KI421412_gene16	3.6e-269	934.5	Desulfuromonadales			2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	1N38V@1224,2WKAZ@28221,42MWC@68525,43SUV@69541,COG0574@1,COG0574@2	NA|NA|NA	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain
MAG.T12.45_02863	1121928.AUHE01000033_gene430	1e-199	702.6	Gordoniaceae	insI1	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07482					ko00000				Bacteria	2GMZX@201174,4GASI@85026,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase and inactivated derivatives IS30 family
MAG.T12.45_02864	110319.CF8_4229	2.8e-132	478.4	Actinobacteria				ko:K07497					ko00000				Bacteria	2GKDY@201174,COG2801@1,COG2801@2	NA|NA|NA	L	PFAM Integrase catalytic
MAG.T12.45_02865	526226.Gbro_2585	5.7e-138	497.3	Gordoniaceae													Bacteria	2I9ZX@201174,4GFWP@85026,COG4974@1,COG4974@2	NA|NA|NA	L	integrase domain protein SAM domain protein
MAG.T12.45_02866	526226.Gbro_2584	2.6e-234	818.1	Gordoniaceae				ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	2IBD6@201174,4GFSJ@85026,COG4974@1,COG4974@2	NA|NA|NA	L	PFAM integrase family protein
MAG.T12.45_02867	253839.SSNG_07182	3.8e-15	87.8	Actinobacteria													Bacteria	2H714@201174,COG1484@1,COG1484@2	NA|NA|NA	L	PFAM IstB domain protein ATP-binding protein
MAG.T12.45_02870	1173027.Mic7113_0392	7.3e-42	178.3	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T12.45_02871	1173027.Mic7113_0392	2.8e-37	163.3	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T12.45_02872	1211815.CBYP010000024_gene1543	1.6e-122	446.0	Actinobacteria	rgpA			ko:K12996					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	2IBM0@201174,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyltransferase
MAG.T12.45_02873	110319.CF8_3325	7e-11	74.7	Bacteria			2.1.1.107,2.1.1.294,2.7.1.181,2.7.11.1	ko:K02496,ko:K05802,ko:K08884,ko:K18827	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194,R10657,R10658	RC00002,RC00003,RC00078,RC00871,RC03220	ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko02000	1.A.23.1.1			Bacteria	COG2959@1,COG2959@2	NA|NA|NA	H	enzyme of heme biosynthesis
MAG.T12.45_02874	1095767.CAHD01000213_gene631	4.1e-103	382.1	Cellulomonadaceae				ko:K07027					ko00000,ko02000	4.D.2			Bacteria	2GMAV@201174,4F0KN@85016,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
MAG.T12.45_02876	1211815.CBYP010000014_gene3463	1.3e-35	157.1	Actinobacteria													Bacteria	2CK5M@1,2IQNJ@201174,33W5S@2	NA|NA|NA		
MAG.T12.45_02877	1304865.JAGF01000001_gene1186	3.6e-162	578.9	Actinobacteria													Bacteria	2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T12.45_02878	675635.Psed_2142	1.6e-30	139.0	Pseudonocardiales													Bacteria	2B57P@1,2IFRB@201174,31Y1M@2,4E3ZW@85010	NA|NA|NA	S	Protein of unknown function (DUF3052)
MAG.T12.45_02879	477641.MODMU_1853	0.0	1327.0	Frankiales	aceE		1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJRE@201174,4ESAA@85013,COG2609@1,COG2609@2	NA|NA|NA	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MAG.T12.45_02880	1150864.MILUP08_40902	2.1e-26	126.7	Micromonosporales				ko:K18566	ko00332,ko01130,map00332,map01130		R10745,R10746	RC00004,RC00096	ko00000,ko00001,ko01000				Bacteria	2I9GA@201174,4DD5V@85008,COG0454@1,COG0456@2	NA|NA|NA	K	Acetyltransferase (GNAT) family
MAG.T12.45_02881	1283283.ATXA01000038_gene2291	3.9e-47	195.7	Actinobacteria													Bacteria	2IAG8@201174,COG3386@1,COG3386@2	NA|NA|NA	G	PFAM SMP-30 Gluconolaconase
MAG.T12.45_02882	246196.MSMEI_1685	1.5e-13	81.6	Actinobacteria				ko:K07483,ko:K07497					ko00000				Bacteria	2IP84@201174,COG2963@1,COG2963@2	NA|NA|NA	L	4.5 Transposon and IS
MAG.T12.45_02883	33876.JNXY01000001_gene6365	5.5e-117	427.6	Micromonosporales				ko:K07497					ko00000				Bacteria	2GNRT@201174,4DHN8@85008,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
MAG.T12.45_02884	1193181.BN10_160001	1.7e-195	688.7	Intrasporangiaceae				ko:K07493					ko00000				Bacteria	2GM8F@201174,4FJAV@85021,COG3328@1,COG3328@2	NA|NA|NA	L	Transposase, Mutator family
MAG.T12.45_02885	710696.Intca_0789	5.4e-21	106.7	Intrasporangiaceae													Bacteria	2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
MAG.T12.45_02886	1380354.JIAN01000005_gene2339	3.1e-51	209.1	Actinobacteria				ko:K02529					ko00000,ko03000				Bacteria	2GQER@201174,COG1609@1,COG1609@2	NA|NA|NA	K	PFAM regulatory protein LacI
MAG.T12.45_02887	680646.RMDY18_14900	2.9e-37	161.8	Micrococcaceae	rseP			ko:K11749	ko02024,ko04112,map02024,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	1W7YP@1268,2GJJT@201174,COG0750@1,COG0750@2	NA|NA|NA	M	Peptidase family M50
MAG.T12.45_02888	1123052.AUDF01000012_gene812	4.6e-26	125.2	Microbacteriaceae				ko:K07090					ko00000				Bacteria	2I5VT@201174,4FNYV@85023,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T12.45_02889	40571.JOEA01000017_gene507	2.2e-178	631.7	Pseudonocardiales	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS06430,iJN678.gcpE	Bacteria	2GK2S@201174,4DZX0@85010,COG0821@1,COG0821@2	NA|NA|NA	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MAG.T12.45_02890	1306174.JODP01000021_gene193	2.9e-101	375.6	Actinobacteria				ko:K06946					ko00000				Bacteria	2IES1@201174,COG3596@1,COG3596@2,COG3597@1,COG3597@2	NA|NA|NA	D	Domain of unknown function (DUF697)
MAG.T12.45_02892	1382356.JQMP01000003_gene1517	5.1e-86	324.7	Thermomicrobia	adhA		1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	27YST@189775,2G829@200795,COG1064@1,COG1064@2	NA|NA|NA	S	Alcohol dehydrogenase GroES-like domain
MAG.T12.45_02893	66377.JOBH01000024_gene3357	6.5e-79	300.8	Actinobacteria				ko:K06976					ko00000				Bacteria	2GMD2@201174,COG3393@1,COG3393@2	NA|NA|NA	S	acetyltransferase
MAG.T12.45_02894	479431.Namu_2200	5.4e-240	837.0	Frankiales	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJ9G@201174,4ERXH@85013,COG0442@1,COG0442@2	NA|NA|NA	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MAG.T12.45_02895	1120950.KB892747_gene3703	1.1e-66	260.0	Propionibacteriales			3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120		R00947	RC00078	ko00000,ko00001,ko01000				Bacteria	2HZ7F@201174,4DQFA@85009,COG1011@1,COG1011@2	NA|NA|NA	S	HAD-superfamily hydrolase, subfamily IA, variant 1
MAG.T12.45_02896	1035308.AQYY01000002_gene664	2.7e-32	145.6	Bacteria													Bacteria	COG5274@1,COG5274@2	NA|NA|NA	C	heme binding
MAG.T12.45_02897	591157.SSLG_01071	2.1e-31	142.9	Actinobacteria	surf1			ko:K14998					ko00000,ko03029	3.D.4.8			Bacteria	2GR90@201174,COG3346@1,COG3346@2	NA|NA|NA	S	SURF1-like protein
MAG.T12.45_02898	208439.AJAP_20185	2.9e-31	141.0	Pseudonocardiales	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iNJ661.Rv2130c	Bacteria	2GJZR@201174,4DYWB@85010,COG0215@1,COG0215@2	NA|NA|NA	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins
MAG.T12.45_02899	645465.ACUR01000099_gene2676	8e-168	597.0	Actinobacteria	tldD			ko:K03568					ko00000,ko01002				Bacteria	2GJ4E@201174,COG0312@1,COG0312@2	NA|NA|NA	S	Modulator of DNA gyrase
MAG.T12.45_02900	67281.JNZZ01000018_gene544	2.5e-104	386.0	Streptomyces griseus group	tldD3												Bacteria	2GZPS@201174,419X8@629295,COG0312@1,COG0312@2	NA|NA|NA	S	Putative modulator of DNA gyrase
MAG.T12.45_02901	935866.JAER01000002_gene1853	7.9e-26	122.5	Propionibacteriales				ko:K09165					ko00000				Bacteria	2IQ6Z@201174,4DS6C@85009,COG3360@1,COG3360@2	NA|NA|NA	S	Dodecin
MAG.T12.45_02902	196162.Noca_2569	1.8e-07	62.4	Propionibacteriales													Bacteria	2EGIC@1,2I19N@201174,33AAH@2,4DSK8@85009	NA|NA|NA	S	Protein of unknown function (DUF3099)
MAG.T12.45_02903	395965.Msil_2988	2.8e-84	318.9	Beijerinckiaceae			1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000				Bacteria	1MXER@1224,2V9AU@28211,3NBTI@45404,COG0167@1,COG0167@2	NA|NA|NA	F	Dihydroorotate dehydrogenase
MAG.T12.45_02904	1184607.AUCHE_05_04270	0.0	1383.2	Actinobacteria	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114	1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1	ko:K00176,ko:K00528,ko:K03737,ko:K20449	ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00307,M00620	R01196,R01197,R03164,R10159,R10866	RC00004,RC02422,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000			iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920	Bacteria	2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1149@1,COG1149@2	NA|NA|NA	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MAG.T12.45_02905	1304865.JAGF01000001_gene2477	0.0	2345.1	Actinobacteria	nifJ		1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1144@1,COG1144@2,COG1145@1,COG1145@2	NA|NA|NA	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MAG.T12.45_02909	889378.Spiaf_2269	8e-149	533.9	Bacteria	amyA	GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970	Bacteria	COG0366@1,COG0366@2	NA|NA|NA	G	hydrolase activity, hydrolyzing O-glycosyl compounds
MAG.T12.45_02910	234267.Acid_3076	9.8e-26	124.0	Acidobacteria			2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000				Bacteria	3Y8HB@57723,COG2091@1,COG2091@2	NA|NA|NA	H	4'-phosphopantetheinyl transferase superfamily
MAG.T12.45_02911	1089455.MOPEL_080_00430	0.0	1257.3	Dermatophilaceae													Bacteria	2GIZP@201174,4F7M0@85018,COG4770@1,COG4770@2,COG4799@1,COG4799@2	NA|NA|NA	I	Acetyl-CoA carboxylase, central region
MAG.T12.45_02912	467200.ACFA01000086_gene1346	1.2e-221	776.2	Actinobacteria	acsA		6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GNE8@201174,COG0365@1,COG0365@2	NA|NA|NA	I	synthetase
MAG.T12.45_02913	1123065.ATWL01000009_gene974	4.8e-50	204.1	Actinobacteria			3.6.1.55	ko:K03574					ko00000,ko01000,ko03400				Bacteria	2IKKB@201174,COG1051@1,COG1051@2	NA|NA|NA	F	Nudix hydrolase
MAG.T12.45_02915	103733.JNYO01000008_gene5422	1.4e-46	193.7	Pseudonocardiales													Bacteria	2GKAY@201174,4E36B@85010,COG5012@1,COG5012@2	NA|NA|NA	S	cobalamin binding protein
MAG.T12.45_02916	479435.Kfla_5843	3.5e-76	291.2	Propionibacteriales	nth		4.2.99.18	ko:K07457,ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GNE5@201174,4DQDJ@85009,COG0177@1,COG0177@2	NA|NA|NA	L	HhH-GPD superfamily base excision DNA repair protein
MAG.T12.45_02918	1121106.JQKB01000013_gene5441	1.2e-07	63.9	Alphaproteobacteria													Bacteria	1QW7K@1224,2U79M@28211,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_02919	1280946.HY29_18285	1.6e-36	160.2	Alphaproteobacteria													Bacteria	1NPD3@1224,2UX3E@28211,COG2850@1,COG2850@2	NA|NA|NA	S	Cupin superfamily protein
MAG.T12.45_02920	1231391.AMZF01000003_gene3115	2.6e-50	205.7	Alcaligenaceae													Bacteria	1N3A2@1224,2W95G@28216,3T7RQ@506,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T12.45_02921	1352941.M877_37700	4.6e-31	142.5	Actinobacteria	sagD			ko:K09136					ko00000,ko03009				Bacteria	2GKBS@201174,COG1944@1,COG1944@2	NA|NA|NA	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding
MAG.T12.45_02923	1278073.MYSTI_04797	4.8e-63	248.8	Deltaproteobacteria	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576											Bacteria	1MU76@1224,2WIM5@28221,42NGU@68525,COG0635@1,COG0635@2	NA|NA|NA	H	Involved in the biosynthesis of porphyrin-containing compound
MAG.T12.45_02924	318586.Pden_4195	8.2e-32	144.4	Alphaproteobacteria	sagB												Bacteria	1PUI1@1224,2U13C@28211,COG0778@1,COG0778@2	NA|NA|NA	C	Nitroreductase family
MAG.T12.45_02927	1380386.JIAW01000001_gene4637	2.7e-105	389.0	Mycobacteriaceae	tdt												Bacteria	2357X@1762,2GKPA@201174,COG1275@1,COG1275@2	NA|NA|NA	P	C4-dicarboxylate transporter malic acid transport protein
MAG.T12.45_02928	1169161.KB897741_gene1993	6.2e-90	337.8	Actinobacteria	pstS	GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134		ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	2GJXD@201174,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
MAG.T12.45_02929	1077972.ARGLB_029_00020	4.8e-11	75.1	Bacteria													Bacteria	2ECD9@1,31QH2@2	NA|NA|NA		
MAG.T12.45_02930	935866.JAER01000004_gene3859	1.6e-37	161.8	Propionibacteriales													Bacteria	2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009	NA|NA|NA	S	Domain of unknown function (DUF4287)
MAG.T12.45_02931	765911.Thivi_2384	4.9e-23	115.2	Chromatiales	MA20_05910			ko:K03668,ko:K09914					ko00000				Bacteria	1NGG1@1224,1S7JT@1236,1WYQQ@135613,COG3187@1,COG3187@2	NA|NA|NA	O	META domain
MAG.T12.45_02932	67267.JNXT01000003_gene4090	1.8e-09	68.6	Actinobacteria													Bacteria	2B1UQ@1,2GTR9@201174,31UAQ@2	NA|NA|NA		
MAG.T12.45_02933	1280390.CBQR020000100_gene2320	3.2e-90	338.6	Paenibacillaceae													Bacteria	1TSWF@1239,274FR@186822,4HANV@91061,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T12.45_02934	543632.JOJL01000004_gene4174	3.7e-34	152.1	Micromonosporales													Bacteria	2EJNG@1,2H04Y@201174,33DDC@2,4DM96@85008	NA|NA|NA	S	Domain of unknown function (DUF4386)
MAG.T12.45_02935	1172188.KB911822_gene695	2.9e-15	87.8	Intrasporangiaceae													Bacteria	2DNVA@1,2GRAT@201174,32ZBE@2,4FJSY@85021	NA|NA|NA		
MAG.T12.45_02936	42256.RradSPS_0358	1.3e-205	723.4	Rubrobacteria				ko:K03556					ko00000,ko03000				Bacteria	2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T12.45_02937	469371.Tbis_3586	1.8e-16	92.4	Actinobacteria													Bacteria	2B9QR@1,2H7N9@201174,3233A@2	NA|NA|NA		
MAG.T12.45_02938	298655.KI912266_gene787	1.2e-142	513.1	Frankiales													Bacteria	2GNQB@201174,4ETFP@85013,COG3547@1,COG3547@2	NA|NA|NA	L	transposase IS116 IS110 IS902 family protein
MAG.T12.45_02940	479433.Caci_0641	9.9e-22	109.0	Actinobacteria													Bacteria	2E5A7@1,2IQ7Z@201174,3302F@2	NA|NA|NA	S	Domain of unknown function (DUF4287)
MAG.T12.45_02941	593907.Celgi_0646	4.4e-46	191.8	Cellulomonadaceae				ko:K06377					ko00000				Bacteria	2GNCK@201174,4F210@85016,COG4760@1,COG4760@2	NA|NA|NA	S	Bax inhibitor 1 like
MAG.T12.45_02942	1120949.KB903301_gene6329	4.1e-105	388.3	Micromonosporales													Bacteria	2GP09@201174,4D8JX@85008,COG0111@1,COG0111@2	NA|NA|NA	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
MAG.T12.45_02944	935866.JAER01000019_gene3959	1.9e-63	248.8	Propionibacteriales			3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	2HMJS@201174,4DNQP@85009,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MAG.T12.45_02945	1504319.GM45_3080	4.5e-38	164.5	Actinobacteria				ko:K03567	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	2IS2K@201174,COG2716@1,COG2716@2	NA|NA|NA	E	ACT domain
MAG.T12.45_02947	1906.SFRA_25950	1.2e-100	373.2	Actinobacteria	ppx	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	2GJBN@201174,COG0248@1,COG0248@2	NA|NA|NA	FP	Ppx GppA phosphatase
MAG.T12.45_02948	1184609.KILIM_002_00280	1.2e-57	229.6	Dermatophilaceae	ppx2		3.6.1.11,3.6.1.40	ko:K01524,ko:K09009	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	2I8CS@201174,4F6XI@85018,COG1507@1,COG1507@2	NA|NA|NA	S	Protein of unknown function (DUF501)
MAG.T12.45_02949	266940.Krad_2942	3.4e-72	278.5	Actinobacteria	uvrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K03702,ko:K08999	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GJ03@201174,COG0556@1,COG0556@2	NA|NA|NA	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MAG.T12.45_02950	1449976.KALB_6759	4.1e-91	341.7	Pseudonocardiales	alx			ko:K05794					ko00000				Bacteria	2GIWU@201174,4DYPS@85010,COG0861@1,COG0861@2	NA|NA|NA	P	PFAM Integral membrane protein TerC
MAG.T12.45_02952	446465.Bfae_27310	2.2e-85	322.8	Dermabacteraceae	sbcD			ko:K03547					ko00000,ko03400				Bacteria	2GK9R@201174,4FBAD@85020,COG0420@1,COG0420@2	NA|NA|NA	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MAG.T12.45_02953	263358.VAB18032_25150	3.1e-100	372.1	Micromonosporales													Bacteria	2GK0T@201174,4DCHZ@85008,COG3214@1,COG3214@2	NA|NA|NA	S	Winged helix DNA-binding domain
MAG.T12.45_02954	349521.HCH_05422	2.6e-25	122.1	Oceanospirillales	FolA												Bacteria	1RH02@1224,1S2UN@1236,1XKZU@135619,COG0262@1,COG0262@2	NA|NA|NA	H	RibD C-terminal domain
MAG.T12.45_02955	2074.JNYD01000017_gene4333	6.5e-74	284.3	Pseudonocardiales	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K10979	ko03450,map03450				ko00000,ko00001,ko03400				Bacteria	2GJMU@201174,4E10U@85010,COG1273@1,COG1273@2	NA|NA|NA	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MAG.T12.45_02956	1172188.KB911823_gene665	2.8e-84	319.3	Intrasporangiaceae													Bacteria	2I37Q@201174,4FFGA@85021,COG0025@1,COG0025@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T12.45_02957	110319.CF8_0638	1.6e-57	229.2	Actinobacteria	lemA			ko:K03744					ko00000				Bacteria	2GPS4@201174,COG1704@1,COG1704@2	NA|NA|NA	J	LemA family
MAG.T12.45_02958	1240349.ANGC01000055_gene4012	2.7e-146	525.8	Nocardiaceae	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GNW7@201174,4G3G3@85025,COG4907@1,COG4907@2	NA|NA|NA	S	Predicted membrane protein (DUF2207)
MAG.T12.45_02959	196162.Noca_4423	1.7e-49	203.8	Propionibacteriales			2.7.13.3	ko:K02484,ko:K07653,ko:K07654	ko02020,map02020	M00460,M00461			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2I3U8@201174,4DU9B@85009,COG5002@1,COG5002@2	NA|NA|NA	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MAG.T12.45_02960	66377.JOBH01000010_gene6019	6.8e-66	257.3	Actinobacteria													Bacteria	2GMVN@201174,COG0745@1,COG0745@2	NA|NA|NA	T	response regulator
MAG.T12.45_02961	208444.JNYY01000013_gene7557	4.9e-10	70.1	Pseudonocardiales				ko:K05337					ko00000				Bacteria	2GSJ7@201174,4E6Z9@85010,COG1141@1,COG1141@2	NA|NA|NA	C	4Fe-4S single cluster domain
MAG.T12.45_02962	66429.JOFL01000001_gene4522	9.2e-50	204.5	Actinobacteria	nuoF2		1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GNN9@201174,COG1894@1,COG1894@2	NA|NA|NA	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit
MAG.T12.45_02963	1206731.BAGB01000163_gene7753	3.8e-19	101.7	Nocardiaceae													Bacteria	2GQH2@201174,4G1BH@85025,COG4097@1,COG4097@2	NA|NA|NA	P	Ferric reductase like transmembrane component
MAG.T12.45_02964	235985.BBPN01000004_gene3114	1.3e-32	147.1	Streptacidiphilus	apbE		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	2H74Y@201174,2NF9E@228398,COG1477@1,COG1477@2	NA|NA|NA	H	ApbE family
MAG.T12.45_02967	1120948.KB903217_gene1344	1.6e-19	103.6	Actinobacteria													Bacteria	2IPMP@201174,COG3064@1,COG3064@2,COG4733@1,COG4733@2	NA|NA|NA	M	calcium- and calmodulin-responsive adenylate cyclase activity
MAG.T12.45_02968	1283283.ATXA01000008_gene3123	2.8e-45	188.7	Frankiales													Bacteria	2CA7I@1,2IFD8@201174,2ZTHS@2,4EV1F@85013	NA|NA|NA		
MAG.T12.45_02969	1380370.JIBA01000012_gene3816	6e-67	261.2	Intrasporangiaceae				ko:K04088,ko:K14393		M00742			ko00000,ko00002,ko01000,ko02000	2.A.21.7			Bacteria	2IE4A@201174,4FIM4@85021,COG0330@1,COG0330@2	NA|NA|NA	O	SPFH domain / Band 7 family
MAG.T12.45_02970	2002.JOEQ01000025_gene232	8e-07	60.1	Streptosporangiales				ko:K06975					ko00000				Bacteria	2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2	NA|NA|NA	S	GCN5-related N-acetyl-transferase
MAG.T12.45_02972	1386089.N865_21145	9.9e-68	263.8	Actinobacteria		GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564		ko:K03281,ko:K03455,ko:K03499,ko:K05571,ko:K05844,ko:K07402,ko:K11105					ko00000,ko01000,ko02000,ko03009	2.A.36.6,2.A.37,2.A.38.1,2.A.38.4,2.A.49,2.A.63.1,2.A.63.2			Bacteria	2I2I2@201174,COG0569@1,COG0569@2	NA|NA|NA	P	Ion transport protein
MAG.T12.45_02973	1380390.JIAT01000011_gene2324	1.4e-22	114.0	Rubrobacteria													Bacteria	2GK0H@201174,4CTG0@84995,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T12.45_02974	1298863.AUEP01000012_gene3662	2.7e-36	158.7	Propionibacteriales				ko:K21429					ko00000,ko01002				Bacteria	2GKWI@201174,4DUPV@85009,COG4894@1,COG4894@2	NA|NA|NA	S	LURP-one-related
MAG.T12.45_02975	1386089.N865_21420	5.3e-21	107.1	Intrasporangiaceae													Bacteria	2AY0M@1,2I859@201174,32Z2S@2,4FH02@85021	NA|NA|NA	S	Phospholipase_D-nuclease N-terminal
MAG.T12.45_02976	1229780.BN381_800004	1.5e-06	60.5	Actinobacteria				ko:K11748					ko00000,ko02000	2.A.37.1.2			Bacteria	2DDQ5@1,2HDNV@201174,2ZIVU@2	NA|NA|NA		
MAG.T12.45_02977	1122182.KB903814_gene3437	1.3e-29	137.1	Micromonosporales	kipA												Bacteria	2GITH@201174,4DBQR@85008,COG1984@1,COG1984@2	NA|NA|NA	E	Allophanate hydrolase subunit 2
MAG.T12.45_02978	1151126.AQYI01000006_gene2850	2.8e-34	152.1	Microbacteriaceae	ybgK												Bacteria	2GITH@201174,4FMAJ@85023,COG1984@1,COG1984@2,COG2049@1,COG2049@2	NA|NA|NA	E	Allophanate hydrolase subunit 2
MAG.T12.45_02979	44060.JODL01000024_gene339	1.5e-40	173.3	Actinobacteria	lamB			ko:K07160					ko00000				Bacteria	2GJA1@201174,COG1540@1,COG1540@2	NA|NA|NA	S	Belongs to the UPF0271 (lamB) family
MAG.T12.45_02980	216594.MMAR_1906	6.7e-19	99.8	Mycobacteriaceae													Bacteria	23AN3@1762,2IQKN@201174,COG5552@1,COG5552@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2277)
MAG.T12.45_02981	1043205.AFYF01000087_gene1224	5.5e-91	342.4	Intrasporangiaceae			2.7.8.12	ko:K09809					ko00000,ko01000				Bacteria	2GM0T@201174,4FISM@85021,COG1887@1,COG1887@2	NA|NA|NA	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
MAG.T12.45_02985	526225.Gobs_1233	4.7e-154	550.8	Frankiales	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02836					ko00000,ko03012				Bacteria	2GJ0F@201174,4ERJ3@85013,COG1186@1,COG1186@2	NA|NA|NA	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MAG.T12.45_02986	446468.Ndas_3723	2.7e-99	368.2	Streptosporangiales	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	2GJE1@201174,4EG9N@85012,COG2884@1,COG2884@2	NA|NA|NA	D	ATPases associated with a variety of cellular activities
MAG.T12.45_02987	1048339.KB913029_gene5048	5.2e-82	311.2	Frankiales	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	2GJMA@201174,4ESQ7@85013,COG2177@1,COG2177@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division
MAG.T12.45_02988	768706.Desor_5488	5.8e-31	142.1	Peptococcaceae				ko:K21471,ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	1VAC5@1239,25E3G@186801,267BP@186807,COG0739@1,COG0739@2,COG3883@1,COG3883@2	NA|NA|NA	M	PFAM Peptidase family M23
MAG.T12.45_02989	330084.JNYZ01000010_gene6967	2.6e-56	224.9	Pseudonocardiales	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03664					ko00000				Bacteria	2GJX1@201174,4E2R0@85010,COG0691@1,COG0691@2	NA|NA|NA	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MAG.T12.45_02991	397278.JOJN01000017_gene2520	2.8e-21	108.6	Propionibacteriales													Bacteria	2EBIV@1,2IHZS@201174,335JA@2,4DRF2@85009	NA|NA|NA		
MAG.T12.45_02992	1122994.AUFR01000024_gene25	4.9e-146	524.6	Propionibacteriales	yuaG			ko:K07192	ko04910,map04910				ko00000,ko00001,ko03036,ko04131,ko04147				Bacteria	2GK9I@201174,4DNKB@85009,COG2268@1,COG2268@2	NA|NA|NA	S	Flotillin
MAG.T12.45_02993	2045.KR76_08315	7e-37	161.4	Propionibacteriales				ko:K13573					ko00000,ko03051				Bacteria	2IMC4@201174,4DRG9@85009,COG2378@1,COG2378@2	NA|NA|NA	K	WYL domain
MAG.T12.45_02994	1449353.JQMQ01000005_gene1989	3.7e-44	184.9	Streptacidiphilus	potA		3.6.3.31	ko:K11072	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1			Bacteria	2GJCM@201174,2NG9M@228398,COG3842@1,COG3842@2	NA|NA|NA	E	TOBE domain
MAG.T12.45_02995	1504319.GM45_4535	6.2e-99	367.5	unclassified Actinobacteria (class)	potH			ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GJ5G@201174,3UWG9@52018,COG1176@1,COG1176@2	NA|NA|NA	P	COG1176 ABC-type spermidine putrescine transport system, permease component I
MAG.T12.45_02996	1504319.GM45_4540	3e-95	355.1	unclassified Actinobacteria (class)	potC			ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GJ6Q@201174,3UWPB@52018,COG1177@1,COG1177@2	NA|NA|NA	P	COG1177 ABC-type spermidine putrescine transport system, permease component II
MAG.T12.45_02997	106370.Francci3_3577	1.3e-15	90.5	Frankiales	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Bacteria	2GJ48@201174,4ERPT@85013,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MAG.T12.45_02998	570268.ANBB01000037_gene2671	5e-57	229.2	Streptosporangiales													Bacteria	2GIV0@201174,4EM8V@85012,COG0515@1,COG0515@2	NA|NA|NA	KLT	SMART serine threonine protein kinase
MAG.T12.45_02999	1157637.KB892115_gene4645	1.1e-158	566.6	Actinobacteria													Bacteria	2GJQ9@201174,COG0665@1,COG0665@2	NA|NA|NA	E	FAD dependent oxidoreductase
MAG.T12.45_03000	479435.Kfla_1695	1e-218	766.1	Propionibacteriales	mmsA		1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJI2@201174,4DNVW@85009,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T12.45_03001	1454010.JEOE01000007_gene2007	9.4e-86	323.6	Cellulomonadaceae			2.8.1.7,4.4.1.16	ko:K03980,ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko01011,ko02000	2.A.66.4			Bacteria	2I44K@201174,4F1AQ@85016,COG3266@1,COG3266@2	NA|NA|NA	S	domain, Protein
MAG.T12.45_03002	33898.JRHJ01000011_gene4893	2.6e-207	729.2	Actinobacteria	gabT		2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKVH@201174,COG0160@1,COG0160@2,COG2334@1,COG2334@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T12.45_03003	1032480.MLP_27620	7e-40	170.2	Propionibacteriales													Bacteria	2AWFS@1,2IMS0@201174,31NC1@2,4DVM9@85009	NA|NA|NA		
MAG.T12.45_03004	1120950.KB892707_gene4971	1.5e-45	189.1	Propionibacteriales	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.199	ko:K03438,ko:K13292					ko00000,ko01000,ko03009				Bacteria	2GKSS@201174,4DP3T@85009,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MAG.T12.45_03005	100226.SCO5141	2.8e-103	381.7	Actinobacteria	folP2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJNI@201174,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAG.T12.45_03006	1229203.KI301992_gene1914	9.4e-96	356.7	unclassified Actinobacteria (class)	fmt2		3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	2GKJH@201174,3UXFN@52018,COG1611@1,COG1611@2	NA|NA|NA	S	Possible lysine decarboxylase
MAG.T12.45_03007	298654.FraEuI1c_2189	2.5e-55	221.9	Frankiales	yceI												Bacteria	2GJUB@201174,4ESN7@85013,COG2353@1,COG2353@2	NA|NA|NA	S	Belongs to the UPF0312 family
MAG.T12.45_03008	1003195.SCAT_3996	7.2e-123	447.2	Actinobacteria	dapE	GO:0008150,GO:0040007	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK09@201174,COG0624@1,COG0624@2	NA|NA|NA	E	succinyl-diaminopimelate desuccinylase
MAG.T12.45_03010	953739.SVEN_2974	7.8e-47	193.7	Actinobacteria	pmt		2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100		R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003		GT39		Bacteria	2I2H1@201174,COG1928@1,COG1928@2	NA|NA|NA	O	PFAM glycosyl transferase family 39
MAG.T12.45_03011	100226.SCO3153	2.8e-88	332.0	Actinobacteria	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056					ko00000,ko01000,ko03009				Bacteria	2GJ9Q@201174,COG0313@1,COG0313@2	NA|NA|NA	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MAG.T12.45_03013	1169161.KB897713_gene6746	1.7e-22	113.2	Actinobacteria													Bacteria	2APF8@1,2GVSP@201174,31VJ9@2	NA|NA|NA		
MAG.T12.45_03014	1169161.KB897713_gene6745	4.1e-17	94.0	Actinobacteria													Bacteria	2BUP0@1,2HB4B@201174,32PZX@2	NA|NA|NA		
MAG.T12.45_03015	1121933.AUHH01000010_gene2519	2.7e-173	614.8	Actinobacteria													Bacteria	2IC5F@201174,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_03016	1121933.AUHH01000010_gene2518	1.8e-46	191.8	Actinobacteria				ko:K07727					ko00000,ko03000				Bacteria	2ISZ0@201174,COG3655@1,COG3655@2	NA|NA|NA	K	Cro/C1-type HTH DNA-binding domain
MAG.T12.45_03017	1193181.BN10_560016	2.1e-184	652.1	Intrasporangiaceae													Bacteria	2HZZ8@201174,4FHJM@85021,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_03018	455632.SGR_872	2.3e-10	71.6	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IRNG@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_03020	1172179.AUKV01000005_gene5828	3e-24	118.2	Actinobacteria				ko:K03088					ko00000,ko03021				Bacteria	2IKVM@201174,COG1595@1,COG1595@2	NA|NA|NA	K	belongs to the sigma-70 factor family, ECF subfamily
MAG.T12.45_03021	1043205.AFYF01000045_gene2925	2.7e-08	65.9	Intrasporangiaceae													Bacteria	2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021	NA|NA|NA	S	Protein of unknown function (DUF2975)
MAG.T12.45_03022	35754.JNYJ01000011_gene741	4.3e-22	110.5	Micromonosporales	yozG			ko:K07727					ko00000,ko03000				Bacteria	2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2	NA|NA|NA	K	Cro/C1-type HTH DNA-binding domain
MAG.T12.45_03023	1121019.AUMN01000003_gene1021	5.8e-52	210.3	Actinobacteria	vapC			ko:K07062					ko00000,ko01000,ko02048				Bacteria	2IS29@201174,COG1487@1,COG1487@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T12.45_03024	1108045.GORHZ_171_00530	2e-22	111.3	Actinobacteria				ko:K21495					ko00000,ko02048				Bacteria	2GSHN@201174,COG4691@1,COG4691@2	NA|NA|NA	S	Plasmid stability protein
MAG.T12.45_03026	710696.Intca_1058	1.9e-50	205.3	Intrasporangiaceae	icmB		5.4.99.13,5.4.99.2,5.4.99.63	ko:K01849,ko:K11942,ko:K14447	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000				Bacteria	2IFJD@201174,4FGQ3@85021,COG2185@1,COG2185@2	NA|NA|NA	I	B12 binding domain
MAG.T12.45_03027	1157637.KB892113_gene4772	2.4e-241	841.6	Actinobacteria	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GISS@201174,COG0210@1,COG0210@2	NA|NA|NA	L	DNA helicase
MAG.T12.45_03029	1906.SFRA_22065	2.4e-46	192.2	Bacteria													Bacteria	COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T12.45_03030	1283283.ATXA01000012_gene4764	1.5e-19	101.7	Frankiales													Bacteria	2IQI4@201174,4ET66@85013,COG1917@1,COG1917@2	NA|NA|NA	S	conserved protein, contains double-stranded beta-helix domain
MAG.T12.45_03031	1464048.JNZS01000006_gene4063	2.6e-72	278.5	Micromonosporales	lipB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100		R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000				Bacteria	2GJIX@201174,4DADI@85008,COG0321@1,COG0321@2	NA|NA|NA	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
MAG.T12.45_03032	1306174.JODP01000001_gene5399	6.7e-66	256.9	Actinobacteria	ppk2	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GKRN@201174,COG2326@1,COG2326@2	NA|NA|NA	G	polyphosphate kinase
MAG.T12.45_03033	1380356.JNIK01000001_gene2188	3.8e-48	197.6	Frankiales	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131			iNJ661.Rv2445c	Bacteria	2IFBU@201174,4ESUM@85013,COG0105@1,COG0105@2	NA|NA|NA	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MAG.T12.45_03034	1120936.KB907209_gene1847	6.3e-11	73.6	Bacteria													Bacteria	2EHND@1,33BE5@2	NA|NA|NA	S	Protein of unknown function (DUF4233)
MAG.T12.45_03035	1048339.KB913029_gene4866	1.1e-120	440.3	Frankiales	folC		6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJP2@201174,4ERQF@85013,COG0285@1,COG0285@2	NA|NA|NA	H	Mur ligase, middle domain protein
MAG.T12.45_03036	1123237.Salmuc_04555	2.8e-39	168.7	Alphaproteobacteria													Bacteria	1MXXT@1224,2U9WZ@28211,COG1961@1,COG1961@2	NA|NA|NA	L	Site-specific recombinases, DNA invertase Pin homologs
MAG.T12.45_03038	1283283.ATXA01000009_gene3212	9.6e-26	124.4	Actinobacteria													Bacteria	2DRK0@1,2I7B6@201174,33C4R@2	NA|NA|NA		
MAG.T12.45_03039	653045.Strvi_8468	4.9e-35	154.1	Actinobacteria													Bacteria	2DWHI@1,2IKAK@201174,340CG@2	NA|NA|NA		
MAG.T12.45_03040	653045.Strvi_2601	4.2e-271	940.6	Actinobacteria													Bacteria	2GK5Z@201174,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T12.45_03041	100226.SCO4349	5.5e-186	657.5	Actinobacteria													Bacteria	2CA8D@1,2I8TK@201174,2ZA16@2	NA|NA|NA		
MAG.T12.45_03042	653045.Strvi_8465	1.1e-189	669.5	Actinobacteria				ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	2GX0Z@201174,COG4974@1,COG4974@2	NA|NA|NA	L	'Phage' integrase family
MAG.T12.45_03045	1121926.AXWO01000005_gene411	1.7e-20	105.5	Actinobacteria				ko:K03892					ko00000,ko03000				Bacteria	2IRF0@201174,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T12.45_03046	1121017.AUFG01000022_gene2176	5.5e-95	354.4	Intrasporangiaceae	fieF												Bacteria	2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2	NA|NA|NA	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAG.T12.45_03048	84531.JMTZ01000014_gene2798	7.1e-32	145.6	Bacteria													Bacteria	2EK9G@1,33DZS@2	NA|NA|NA		
MAG.T12.45_03050	1121405.dsmv_0678	2.7e-137	496.1	Proteobacteria													Bacteria	1RFBU@1224,2C3RM@1,2Z9H1@2	NA|NA|NA		
MAG.T12.45_03051	84531.JMTZ01000014_gene2801	5.5e-152	545.0	Gammaproteobacteria													Bacteria	1QVR5@1224,1T2HN@1236,2DBKT@1,2Z9V9@2	NA|NA|NA		
MAG.T12.45_03052	1116232.AHBF01000163_gene5903	1e-139	504.2	Actinobacteria													Bacteria	28N6D@1,2HMGF@201174,2ZBB9@2	NA|NA|NA		
MAG.T12.45_03053	1449347.JQLN01000007_gene980	1.1e-49	203.8	Bacteria													Bacteria	COG4249@1,COG4249@2	NA|NA|NA	S	B-1 B cell differentiation
MAG.T12.45_03055	369723.Strop_4549	1.8e-25	124.0	Micromonosporales													Bacteria	2ATXZ@1,2GN21@201174,31JHI@2,4D910@85008	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T12.45_03057	561175.KB894095_gene2362	2e-68	266.9	Streptosporangiales	rmuC			ko:K09760					ko00000				Bacteria	2GP4U@201174,4EHTZ@85012,COG1322@1,COG1322@2	NA|NA|NA	S	RmuC family
MAG.T12.45_03059	1380354.JIAN01000008_gene3433	3.2e-122	444.9	Cellulomonadaceae	ispH		1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011			iIT341.HP0400,iLJ478.TM1444	Bacteria	2GIZ7@201174,4F107@85016,COG0761@1,COG0761@2	NA|NA|NA	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MAG.T12.45_03060	321955.AAGP01000021_gene1877	6.4e-107	394.4	Brevibacteriaceae	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJAS@201174,4F8CF@85019,COG1570@1,COG1570@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MAG.T12.45_03061	593907.Celgi_0687	1.9e-11	75.1	Cellulomonadaceae	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GR0U@201174,4F2SG@85016,COG1722@1,COG1722@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MAG.T12.45_03062	525904.Tter_2417	1.7e-10	72.0	Bacteria				ko:K09932					ko00000				Bacteria	COG3224@1,COG3224@2	NA|NA|NA		
MAG.T12.45_03063	134676.ACPL_4177	2.7e-59	236.5	Actinobacteria													Bacteria	2ID0G@201174,COG2199@1,COG3706@2	NA|NA|NA	T	GGDEF domain
MAG.T12.45_03065	1123320.KB889667_gene2958	9e-242	842.8	Actinobacteria	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369		ko:K13527	ko03050,map03050	M00342			ko00000,ko00001,ko00002,ko03051				Bacteria	2GMR1@201174,COG1222@1,COG1222@2	NA|NA|NA	O	AAA ATPase forming ring-shaped complexes
MAG.T12.45_03066	1137269.AZWL01000002_gene6306	4.2e-112	411.4	Actinobacteria	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.219,2.1.1.220	ko:K07442					ko00000,ko01000,ko03016				Bacteria	2GJPD@201174,COG2519@1,COG2519@2	NA|NA|NA	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MAG.T12.45_03067	1120950.KB892708_gene4422	8.8e-63	247.7	Propionibacteriales													Bacteria	2GJBZ@201174,4DNGY@85009,COG1994@1,COG1994@2	NA|NA|NA	S	Belongs to the peptidase M50B family
MAG.T12.45_03068	479435.Kfla_3207	8.2e-90	337.0	Propionibacteriales	recB		3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJC5@201174,4DP6M@85009,COG2887@1,COG2887@2	NA|NA|NA	L	Protein of unknown function (DUF2800)
MAG.T12.45_03069	1304865.JAGF01000001_gene3502	7.4e-68	263.8	Cellulomonadaceae													Bacteria	2HD07@201174,4F18I@85016,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T12.45_03070	1304865.JAGF01000001_gene3501	3.8e-128	464.5	Cellulomonadaceae				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GKEH@201174,4F0VG@85016,COG1131@1,COG1131@2	NA|NA|NA	V	PFAM ABC transporter related
MAG.T12.45_03071	1304865.JAGF01000001_gene3500	5e-69	267.7	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GMSI@201174,COG3559@1,COG3559@2	NA|NA|NA	M	Exporter of polyketide
MAG.T12.45_03072	1304865.JAGF01000001_gene3500	3.4e-124	451.4	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GMSI@201174,COG3559@1,COG3559@2	NA|NA|NA	M	Exporter of polyketide
MAG.T12.45_03073	68194.JNXR01000009_gene5140	2.5e-13	82.8	Actinobacteria													Bacteria	2DDE4@1,2I38G@201174,2ZHP5@2	NA|NA|NA		
MAG.T12.45_03074	446469.Sked_30030	0.0	1082.8	Actinobacteria													Bacteria	2GJJC@201174,COG0474@1,COG0474@2	NA|NA|NA	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC
MAG.T12.45_03075	397278.JOJN01000009_gene3672	3.2e-43	181.0	Propionibacteriales													Bacteria	2IKPX@201174,4DRBT@85009,COG4898@1,COG4898@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2200)
MAG.T12.45_03077	1136417.AZWE01000012_gene2545	1.7e-08	67.8	Micromonosporales	pspC			ko:K03973					ko00000,ko02048,ko03000				Bacteria	2GIVS@201174,4DAQE@85008,COG1983@1,COG1983@2	NA|NA|NA	KT	PspC domain
MAG.T12.45_03078	469383.Cwoe_1650	7.6e-59	234.6	Rubrobacteria	tcsS3												Bacteria	2GJ4J@201174,4CRNY@84995,COG1983@1,COG1983@2,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T12.45_03079	479432.Sros_1229	5.6e-65	254.2	Streptosporangiales	degU			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2	NA|NA|NA	T	helix_turn_helix, Lux Regulon
MAG.T12.45_03080	1121272.KB903254_gene6728	6.4e-77	294.7	Micromonosporales	fbpC		3.6.3.30	ko:K02010	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10			Bacteria	2GJCM@201174,4DCIX@85008,COG3842@1,COG3842@2	NA|NA|NA	P	TOBE domain
MAG.T12.45_03081	318424.EU78_14165	1.4e-114	420.2	Mycobacteriaceae	sfuB			ko:K02011	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	2347P@1762,2GKPT@201174,COG1178@1,COG1178@2	NA|NA|NA	P	binding-protein-dependent transport systems inner membrane component
MAG.T12.45_03082	1078020.KEK_20058	2e-109	402.5	Mycobacteriaceae				ko:K02012	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	236RG@1762,2HPZ8@201174,COG1840@1,COG1840@2	NA|NA|NA	P	Extracellular solute-binding protein
MAG.T12.45_03083	263358.VAB18032_00585	2.7e-167	595.5	Micromonosporales	yheS_2			ko:K06158,ko:K18230	ko02010,map02010				ko00000,ko00001,ko01504,ko02000,ko03012	3.A.1.120			Bacteria	2GK9S@201174,4DA8K@85008,COG0488@1,COG0488@2	NA|NA|NA	S	ATPases associated with a variety of cellular activities
MAG.T12.45_03084	446462.Amir_6924	7.1e-97	360.9	Pseudonocardiales	nagA		3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130		R02059	RC00166,RC00300	ko00000,ko00001,ko01000				Bacteria	2GK1E@201174,4DX8Z@85010,COG1820@1,COG1820@2	NA|NA|NA	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MAG.T12.45_03088	479435.Kfla_3707	8.1e-70	270.8	Propionibacteriales	cphB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0042802,GO:0042803,GO:0043170,GO:0044238,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.6	ko:K13282			R09722	RC00064,RC00141	ko00000,ko01000,ko01002			iJN678.slr2001	Bacteria	2I93U@201174,4DP1Z@85009,COG4242@1,COG4242@2	NA|NA|NA	PQ	Peptidase family S51
MAG.T12.45_03089	43759.JNWK01000070_gene4557	2.7e-35	155.2	Actinobacteria	sixA			ko:K08296					ko00000,ko01000				Bacteria	2GJ0I@201174,COG2062@1,COG2062@2	NA|NA|NA	T	phosphohistidine phosphatase, SixA
MAG.T12.45_03090	313589.JNB_03230	6.4e-104	384.4	Intrasporangiaceae	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009			iNJ661.Rv3042c	Bacteria	2GJDH@201174,4FFIF@85021,COG0560@1,COG0560@2,COG3830@1,COG3830@2	NA|NA|NA	E	phosphoserine phosphatase
MAG.T12.45_03092	1394178.AWOO02000005_gene3609	1.2e-237	829.3	Streptosporangiales	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680		ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	2GIRT@201174,4EGCZ@85012,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MAG.T12.45_03094	1116232.AHBF01000113_gene4604	5.1e-245	853.6	Actinobacteria	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711	Bacteria	2H1PI@201174,COG0033@1,COG0033@2	NA|NA|NA	G	Phosphoglucomutase
MAG.T12.45_03095	1996.JOFO01000054_gene1185	1.4e-55	223.4	Streptosporangiales				ko:K07052					ko00000				Bacteria	2GMJ1@201174,4EG7A@85012,COG1266@1,COG1266@2	NA|NA|NA	S	CAAX protease self-immunity
MAG.T12.45_03096	985054.JQEZ01000003_gene1066	1.5e-06	60.5	Alphaproteobacteria			4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUMZ@1224,2TUKX@28211,COG0457@1,COG0457@2,COG5616@1,COG5616@2	NA|NA|NA	T	Adenylate cyclase
MAG.T12.45_03097	864051.BurJ1DRAFT_3784	2.2e-34	151.4	unclassified Burkholderiales	lytT			ko:K02477,ko:K07705	ko02020,map02020	M00492			ko00000,ko00001,ko00002,ko02022				Bacteria	1KKZT@119065,1MUE8@1224,2VKFT@28216,COG3279@1,COG3279@2	NA|NA|NA	K	LytTr DNA-binding domain
MAG.T12.45_03099	1048339.KB913029_gene1850	4.2e-38	166.0	Actinobacteria	pilV	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840		ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	2IHD8@201174,COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
MAG.T12.45_03100	1304865.JAGF01000001_gene3205	7.6e-12	77.8	Actinobacteria													Bacteria	2FCR1@1,2H815@201174,344U8@2	NA|NA|NA		
MAG.T12.45_03101	593907.Celgi_1807	1.2e-91	344.4	Actinobacteria													Bacteria	2ID24@201174,COG4726@1,COG4726@2	NA|NA|NA	NU	pilus assembly protein PilW
MAG.T12.45_03102	446466.Cfla_1829	2.1e-71	275.8	Cellulomonadaceae	hofD		3.4.23.43	ko:K02654		M00331			ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2			Bacteria	2GJ7K@201174,4F1IU@85016,COG1989@1,COG1989@2	NA|NA|NA	NOU	Type IV leader peptidase family
MAG.T12.45_03103	1306174.JODP01000013_gene7517	1.3e-68	266.9	Actinobacteria	pilM			ko:K02662					ko00000,ko02035,ko02044				Bacteria	2IBNF@201174,COG4972@1,COG4972@2	NA|NA|NA	NU	pilus assembly protein PilM
MAG.T12.45_03104	593907.Celgi_1801	6.1e-17	94.7	Actinobacteria	pilN			ko:K02663					ko00000,ko02035,ko02044				Bacteria	2IS0C@201174,COG3166@1,COG3166@2	NA|NA|NA	NU	PFAM Fimbrial assembly family protein
MAG.T12.45_03105	266940.Krad_3017	5.1e-08	65.1	Bacteria	mshJ			ko:K02664,ko:K02665,ko:K12280					ko00000,ko02035,ko02044				Bacteria	COG3167@1,COG3167@2	NA|NA|NA	NU	carbon utilization
MAG.T12.45_03107	1120950.KB892708_gene4302	2.7e-155	555.1	Propionibacteriales	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0976	Bacteria	2GJJN@201174,4DPU4@85009,COG0082@1,COG0082@2	NA|NA|NA	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MAG.T12.45_03108	1996.JOFO01000006_gene481	8.2e-43	180.3	Streptosporangiales	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71,4.2.3.4	ko:K00891,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	2GRFW@201174,4EJ4W@85012,COG0703@1,COG0703@2	NA|NA|NA	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MAG.T12.45_03109	471853.Bcav_2021	1.9e-134	485.7	Actinobacteria	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIUZ@201174,COG0337@1,COG0337@2	NA|NA|NA	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MAG.T12.45_03110	479432.Sros_6532	3.2e-50	204.5	Streptosporangiales	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000			iIT341.HP1038	Bacteria	2IMBY@201174,4EJ73@85012,COG0757@1,COG0757@2	NA|NA|NA	E	Catalyzes a trans-dehydration via an enolate intermediate
MAG.T12.45_03111	1210045.ALNP01000009_gene4681	1.2e-12	81.6	Actinobacteria	moxJ			ko:K02030,ko:K02424,ko:K16254	ko00680,ko01120,ko02010,map00680,map01120,map02010	M00234,M00236			ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14			Bacteria	2GIV0@201174,COG0515@1,COG0515@2,COG0834@1,COG0834@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T12.45_03112	1077972.ARGLB_083_00470	3.2e-33	151.0	Actinobacteria													Bacteria	2EIJM@1,2IREQ@201174,33CAY@2	NA|NA|NA		
MAG.T12.45_03113	397278.JOJN01000007_gene3349	9.2e-137	494.2	Propionibacteriales	ydaM												Bacteria	2GNN5@201174,4DWKW@85009,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family group 2
MAG.T12.45_03114	1283287.KB822582_gene2986	1.1e-74	287.3	Actinobacteria													Bacteria	2GP6W@201174,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase
MAG.T12.45_03115	649831.L083_3893	1.8e-106	393.3	Micromonosporales	gba		3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142		R01498	RC00059,RC00451	ko00000,ko00001,ko01000		GH30		Bacteria	2GMWN@201174,4D9UI@85008,COG5520@1,COG5520@2	NA|NA|NA	G	Glycosyl hydrolase family 30 beta sandwich domain
MAG.T12.45_03120	469371.Tbis_2426	5.1e-55	220.7	Pseudonocardiales	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07738					ko00000,ko03000				Bacteria	2IHU9@201174,4E2M8@85010,COG1327@1,COG1327@2	NA|NA|NA	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MAG.T12.45_03121	1150399.AQYK01000002_gene2473	2.6e-11	75.1	Microbacteriaceae													Bacteria	2GWI9@201174,4FQ73@85023,COG1388@1,COG1388@2	NA|NA|NA	M	Lysin motif
MAG.T12.45_03122	1120950.KB892707_gene4592	5.9e-83	313.9	Propionibacteriales	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	2GMBN@201174,4DNCQ@85009,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MAG.T12.45_03123	1169154.KB897780_gene2333	6e-122	444.5	Actinobacteria													Bacteria	2GKEK@201174,COG4320@1,COG4320@2	NA|NA|NA	K	protein conserved in bacteria
MAG.T12.45_03124	471857.Svir_29270	3.4e-163	582.0	Pseudonocardiales	dinG	GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GKT8@201174,4E0JP@85010,COG1199@1,COG1199@2	NA|NA|NA	KL	helicase
MAG.T12.45_03125	1048339.KB913029_gene4763	4.8e-172	610.9	Frankiales	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464		ko:K03665					ko00000,ko03009				Bacteria	2GK55@201174,4ERJ5@85013,COG2262@1,COG2262@2	NA|NA|NA	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MAG.T12.45_03126	1449346.JQMO01000003_gene3598	3.2e-73	282.0	Kitasatospora	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000			iIT341.HP0566,iLJ478.TM1522	Bacteria	2GKUD@201174,2M07M@2063,COG0253@1,COG0253@2	NA|NA|NA	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MAG.T12.45_03127	1306406.ASHX01000001_gene178	5.8e-76	291.2	Actinobacteria	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110		R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016				Bacteria	2GKFT@201174,COG0324@1,COG0324@2	NA|NA|NA	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MAG.T12.45_03128	66377.JOBH01000011_gene2229	2.8e-22	112.5	Actinobacteria			2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Bacteria	2GN3T@201174,COG3885@1,COG3885@2	NA|NA|NA	S	ferrous iron binding
MAG.T12.45_03129	471852.Tcur_3285	1.5e-195	689.1	Streptosporangiales	miaB		2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Bacteria	2GJEV@201174,4EFYX@85012,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAG.T12.45_03130	1121272.KB903272_gene431	2.1e-33	149.1	Micromonosporales	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03565					ko00000,ko03400				Bacteria	2GMRF@201174,4DD5X@85008,COG2137@1,COG2137@2	NA|NA|NA	S	Modulates RecA activity
MAG.T12.45_03131	1172188.KB911821_gene1254	4.7e-89	334.0	Intrasporangiaceae	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Bacteria	2GJ4P@201174,4FFS1@85021,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
# 2595 queries scanned
# Total time (seconds): 4.38275980949
# Rate: 592.09 q/s