# emapper version: emapper-2.0.1 emapper DB: 2.0
# command: ./emapper.py  -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T21.41/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/Bin_prokka//MAG.T21.41/MAG.T21.41.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T21.41/MAG.T21.41 --usemem --override
# time: Wed Feb 25 23:33:23 2026
#query_name	seed_eggNOG_ortholog	seed_ortholog_evalue	seed_ortholog_score	best_tax_level	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	taxonomic scope	eggNOG OGs	best eggNOG OG	COG Functional cat.	eggNOG free text desc.
MAG.T21.41_00004	1356854.N007_16670	6.3e-29	134.0	Alicyclobacillaceae	radC			ko:K03630					ko00000				Bacteria	1V38E@1239,27ANZ@186823,4HG4Q@91061,COG2003@1,COG2003@2	NA|NA|NA	L	RadC-like JAB domain
MAG.T21.41_00007	357808.RoseRS_2675	4.7e-40	172.6	Chloroflexia													Bacteria	2GAP4@200795,376X2@32061,COG2227@1,COG2227@2	NA|NA|NA	H	Nodulation protein S (NodS)
MAG.T21.41_00008	545243.BAEV01000108_gene2772	7.7e-90	337.8	Clostridiaceae	gumK		2.4.1.264	ko:K13659			R09732	RC00005,RC00049	ko00000,ko01000,ko01003		GT70		Bacteria	1UFBR@1239,24DNE@186801,36HXV@31979,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_00009	330214.NIDE3421	9.9e-147	526.6	Bacteria				ko:K07011					ko00000				Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_00010	330214.NIDE3420	5.9e-170	603.6	Bacteria			2.7.8.33,2.7.8.35	ko:K02851			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	COG0472@1,COG0472@2	NA|NA|NA	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity
MAG.T21.41_00011	330214.NIDE3419	1.7e-230	805.1	Bacteria			5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520		R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000				Bacteria	COG1232@1,COG1232@2	NA|NA|NA	H	protoporphyrinogen oxidase activity
MAG.T21.41_00012	330214.NIDE3418	1.3e-184	652.5	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_00013	330214.NIDE3417	1.2e-189	669.1	Nitrospirae	degT												Bacteria	3J09X@40117,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_00016	243233.MCA0178	1.2e-130	473.0	Methylococcales													Bacteria	1MU48@1224,1RQ6V@1236,1XDWC@135618,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_00017	1134912.AJTV01000001_gene1418	6.8e-122	444.1	Methylocystaceae													Bacteria	1NQZ0@1224,2U105@28211,36ZBI@31993,COG0845@1,COG0845@2	NA|NA|NA	M	Biotin-lipoyl like
MAG.T21.41_00018	243233.MCA0176	3e-194	684.9	Methylococcales													Bacteria	1MUA8@1224,1RQ6B@1236,1XEVK@135618,COG1538@1,COG1538@2	NA|NA|NA	MU	Outer membrane efflux protein
MAG.T21.41_00019	179408.Osc7112_1134	5.3e-07	62.8	Oscillatoriales													Bacteria	1G4KP@1117,1H7YH@1150,28MWQ@1,2ZB40@2	NA|NA|NA		
MAG.T21.41_00020	330214.NIDE2263	4.2e-306	1056.6	Nitrospirae	clpB	GO:0003674,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0042802,GO:0043170,GO:0044238,GO:0071704,GO:1901564		ko:K03694,ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Bacteria	3J0AV@40117,COG0542@1,COG0542@2	NA|NA|NA	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
MAG.T21.41_00023	330214.NIDE2260	4.9e-250	870.2	Nitrospirae	comM			ko:K07391					ko00000				Bacteria	3J0ZK@40117,COG0606@1,COG0606@2	NA|NA|NA	O	Magnesium chelatase, subunit ChlI C-terminal
MAG.T21.41_00025	330214.NIDE2258	2.2e-32	144.4	Bacteria													Bacteria	COG1522@1,COG1522@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_00026	330214.NIDE2257	3.3e-138	498.0	Bacteria													Bacteria	COG0673@1,COG0673@2	NA|NA|NA	S	inositol 2-dehydrogenase activity
MAG.T21.41_00027	330214.NIDE2255	5.9e-130	470.3	Nitrospirae	yndB		3.1.1.101,3.1.1.102,3.1.1.45,3.1.1.76	ko:K01061,ko:K06889,ko:K07100,ko:K11750,ko:K21104,ko:K21105,ko:K22249	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222,R11540,R11541	RC00020,RC00041,RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Bacteria	3J1B9@40117,COG0412@1,COG0412@2	NA|NA|NA	Q	Alpha/beta hydrolase family
MAG.T21.41_00029	330214.NIDE2253	2.5e-49	201.4	Bacteria	ygdD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	COG2363@1,COG2363@2	NA|NA|NA	S	Protein of unknown function (DUF423)
MAG.T21.41_00034	330214.NIDE2089	3.1e-29	134.0	Bacteria	XK27_07760												Bacteria	COG4980@1,COG4980@2	NA|NA|NA	D	gas vesicle protein
MAG.T21.41_00035	330214.NIDE2088	4.2e-147	527.3	Nitrospirae	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.199	ko:K03438,ko:K13292					ko00000,ko01000,ko03009				Bacteria	3J0G4@40117,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MAG.T21.41_00036	330214.NIDE2087	2.7e-54	218.0	Bacteria													Bacteria	COG3063@1,COG3063@2	NA|NA|NA	NU	photosynthesis
MAG.T21.41_00037	330214.NIDE2086	0.0	1205.3	Nitrospirae			3.1.11.5,3.1.12.1,3.6.4.12	ko:K01144,ko:K07464,ko:K16898					ko00000,ko01000,ko02048,ko03400				Bacteria	3J16M@40117,COG1074@1,COG1074@2	NA|NA|NA	L	PD-(D/E)XK nuclease superfamily
MAG.T21.41_00038	330214.NIDE1211	2.4e-104	385.2	Bacteria	ydeD												Bacteria	COG0697@1,COG0697@2	NA|NA|NA	EG	spore germination
MAG.T21.41_00040	330214.NIDE1213	1e-174	619.4	Bacteria	desC		1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212		R02222	RC00917	ko00000,ko00001,ko01000,ko01004				Bacteria	COG1398@1,COG1398@2	NA|NA|NA	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
MAG.T21.41_00042	330214.NIDE1215	5.1e-165	587.0	Nitrospirae	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0016	Bacteria	3J0C3@40117,COG0407@1,COG0407@2	NA|NA|NA	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MAG.T21.41_00043	330214.NIDE1216	7.4e-148	530.0	Nitrospirae	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0P9@40117,COG0276@1,COG0276@2	NA|NA|NA	H	Catalyzes the ferrous insertion into protoporphyrin IX
MAG.T21.41_00044	330214.NIDE1217	2.2e-247	861.3	Nitrospirae	hemY		1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS09325	Bacteria	3J0PQ@40117,COG1232@1,COG1232@2	NA|NA|NA	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MAG.T21.41_00048	195105.CN97_06245	1.6e-54	219.2	Alphaproteobacteria	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576		ko:K06147,ko:K12531	ko02020,map02020	M00326			ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	1NSKS@1224,2UQAG@28211,COG5265@1,COG5265@2	NA|NA|NA	V	COG5265 ABC-type transport system involved in Fe-S cluster assembly permease and ATPase components
MAG.T21.41_00049	330214.NIDE3440	5.8e-186	657.5	Nitrospirae													Bacteria	3J0MH@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_00050	330214.NIDE3441	7.7e-239	832.8	Nitrospirae	dnaB		3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112				ko00000,ko00001,ko01000,ko03032				Bacteria	3J0EZ@40117,COG0305@1,COG0305@2	NA|NA|NA	L	Participates in initiation and elongation during chromosome replication
MAG.T21.41_00051	330214.NIDE3442	3.9e-164	584.3	Nitrospirae	hisZ		2.4.2.17,6.1.1.21	ko:K00765,ko:K01892,ko:K02502	ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230	M00026,M00359,M00360	R01071,R03655	RC00055,RC00523,RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	3J13R@40117,COG3705@1,COG3705@2	NA|NA|NA	E	Histidyl-tRNA synthetase
MAG.T21.41_00052	330214.NIDE3443	1e-282	978.8	Nitrospirae	serA		1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0DZ@40117,COG0111@1,COG0111@2,COG4747@1,COG4747@2	NA|NA|NA	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAG.T21.41_00053	330214.NIDE3444	8.5e-207	726.1	Nitrospirae		GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0FC@40117,COG0075@1,COG0075@2	NA|NA|NA	E	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00054	330214.NIDE3445	1.2e-221	775.8	Nitrospirae	CP_0155			ko:K08307,ko:K12204					ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	3J0J4@40117,COG0741@1,COG0741@2,COG1388@1,COG1388@2	NA|NA|NA	M	Lysin motif
MAG.T21.41_00055	330214.NIDE3446	1.6e-117	429.1	Bacteria	bamD			ko:K05807,ko:K08309					ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23		Bacteria	COG4105@1,COG4105@2	NA|NA|NA	S	cell envelope organization
MAG.T21.41_00056	330214.NIDE3447	8.2e-168	596.7	Nitrospirae	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007			iJN678.bioF,iNJ661.Rv1569	Bacteria	3J0XU@40117,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MAG.T21.41_00057	330214.NIDE3448	2e-194	684.9	Nitrospirae	pilT			ko:K02669					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	3J0YS@40117,COG2805@1,COG2805@2	NA|NA|NA	NU	Type II/IV secretion system protein
MAG.T21.41_00059	330214.NIDE1766	8.5e-146	523.5	Bacteria	cusB			ko:K07798,ko:K15727	ko02020,map02020				ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_00060	330214.NIDE1767	5.2e-181	640.6	Nitrospirae	cusC			ko:K15725					ko00000,ko02000	1.B.17.2.2			Bacteria	3J1F2@40117,COG1538@1,COG1538@2	NA|NA|NA	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00062	330214.NIDE1769	2.6e-257	894.4	Nitrospirae	nuoL2		1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0AN@40117,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-quinone oxidoreductase
MAG.T21.41_00063	330214.NIDE1770	0.0	1746.1	Nitrospirae				ko:K09822					ko00000				Bacteria	3J0VY@40117,COG3002@1,COG3002@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2309)
MAG.T21.41_00064	330214.NIDE1771	4e-53	213.8	Nitrospirae				ko:K04752					ko00000				Bacteria	3J17N@40117,COG0347@1,COG0347@2	NA|NA|NA	K	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00065	330214.NIDE1772	0.0	1128.6	Nitrospirae			2.7.13.3	ko:K02003,ko:K02484,ko:K07708,ko:K10942,ko:K14986	ko02020,ko05111,map02020,map05111	M00258,M00497,M00515,M00524			ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1			Bacteria	3J0YT@40117,COG2203@1,COG2203@2,COG3852@1,COG3852@2	NA|NA|NA	T	GAF domain
MAG.T21.41_00066	330214.NIDE1773	1.2e-207	729.2	Nitrospirae				ko:K07714	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	3J0YM@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_00067	330214.NIDE0410	1.2e-111	409.5	Bacteria	cysD		1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0175@1,COG0175@2	NA|NA|NA	EH	sulfate reduction
MAG.T21.41_00068	1100720.ALKN01000031_gene1308	2.3e-56	224.9	Comamonadaceae	MA20_07390		3.1.2.6	ko:K01069,ko:K07455	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000,ko03400				Bacteria	1MVC3@1224,2VICE@28216,4ABG9@80864,COG0491@1,COG0491@2	NA|NA|NA	L	PFAM NUDIX hydrolase
MAG.T21.41_00069	439235.Dalk_0035	3.5e-40	171.8	Proteobacteria													Bacteria	1NZ9S@1224,2F8C0@1,340R0@2	NA|NA|NA		
MAG.T21.41_00070	330214.NIDE1692	5.1e-176	624.0	Bacteria													Bacteria	COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T21.41_00071	330214.NIDE1691	5.4e-194	683.7	Nitrospirae													Bacteria	3J0RT@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00072	330214.NIDE1690	5.3e-57	226.9	Bacteria													Bacteria	COG0840@1,COG0840@2	NA|NA|NA	NT	transmembrane signaling receptor activity
MAG.T21.41_00073	330214.NIDE1688	6.5e-51	206.8	Bacteria	kdpE			ko:K03413	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00074	330214.NIDE1687	0.0	1939.9	Nitrospirae													Bacteria	3J103@40117,COG0841@1,COG0841@2	NA|NA|NA	V	AcrB/AcrD/AcrF family
MAG.T21.41_00075	330214.NIDE1686	2.3e-208	731.5	Nitrospirae													Bacteria	3J13H@40117,COG0845@1,COG0845@2	NA|NA|NA	M	HlyD family secretion protein
MAG.T21.41_00076	330214.NIDE1685	6.2e-231	806.6	Nitrospirae				ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821			ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2			Bacteria	3J140@40117,COG1538@1,COG1538@2	NA|NA|NA	MU	Outer membrane efflux protein
MAG.T21.41_00078	330214.NIDE1683	1.5e-86	325.5	Nitrospirae			5.2.1.8	ko:K03768					ko00000,ko01000,ko03110				Bacteria	3J18H@40117,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T21.41_00079	330214.NIDE1682	1.4e-121	443.0	Bacteria													Bacteria	COG3292@1,COG3292@2	NA|NA|NA		
MAG.T21.41_00080	330214.NIDE1681	9.7e-130	469.5	Nitrospirae	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	3J0PJ@40117,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAG.T21.41_00081	330214.NIDE1680	1.6e-26	124.8	Nitrospirae				ko:K09794					ko00000				Bacteria	2DRP0@1,33CFM@2,3J1BN@40117	NA|NA|NA	S	Protein of unknown function (DUF465)
MAG.T21.41_00082	330214.NIDE1679	3.6e-69	267.7	Nitrospirae	rimI		2.3.1.128	ko:K03789					ko00000,ko01000,ko03009				Bacteria	3J1CI@40117,COG0454@1,COG0456@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
MAG.T21.41_00083	330214.NIDE1678	1.1e-99	369.8	Nitrospirae	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03016				Bacteria	3J0VU@40117,COG1214@1,COG1214@2	NA|NA|NA	O	Glycoprotease family
MAG.T21.41_00084	330214.NIDE1677	1.4e-126	459.1	Bacteria	lolA												Bacteria	COG2834@1,COG2834@2	NA|NA|NA	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MAG.T21.41_00085	330214.NIDE1676	2.2e-238	831.2	Nitrospirae	radA			ko:K04485					ko00000,ko03400				Bacteria	3J0BP@40117,COG1066@1,COG1066@2	NA|NA|NA	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MAG.T21.41_00086	330214.NIDE1675	2.8e-103	381.7	Bacteria	spoU		2.1.1.170,2.1.1.185	ko:K03218,ko:K03437,ko:K03501					ko00000,ko01000,ko03009,ko03016,ko03036				Bacteria	COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T21.41_00088	330214.NIDE0601	7.4e-139	500.0	Nitrospirae			1.17.99.6	ko:K07058,ko:K18979					ko00000,ko01000,ko03016				Bacteria	3J17V@40117,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T21.41_00089	330214.NIDE0602	1e-166	592.8	Nitrospirae	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0FN@40117,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00092	330214.NIDE3363	4.7e-110	404.1	Nitrospirae	tolQ			ko:K03561,ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.1,1.A.30.2.2			Bacteria	3J0PX@40117,COG0811@1,COG0811@2	NA|NA|NA	U	MotA/TolQ/ExbB proton channel family
MAG.T21.41_00093	330214.NIDE3362	1.3e-70	272.3	Nitrospirae	tolR			ko:K03559,ko:K03560					ko00000,ko02000	1.A.30.2.1,1.A.30.2.2			Bacteria	3J0T6@40117,COG0848@1,COG0848@2	NA|NA|NA	U	Biopolymer transport protein ExbD/TolR
MAG.T21.41_00094	330214.NIDE3361	3e-157	561.6	Bacteria				ko:K03646,ko:K03832					ko00000,ko02000	2.C.1.1,2.C.1.2			Bacteria	COG0810@1,COG0810@2	NA|NA|NA	M	energy transducer activity
MAG.T21.41_00095	330214.NIDE3360	4.2e-173	614.4	Nitrospirae	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998		ko:K03641					ko00000,ko02000	2.C.1.2			Bacteria	3J0U9@40117,COG0823@1,COG0823@2	NA|NA|NA	U	WD40-like Beta Propeller Repeat
MAG.T21.41_00096	330214.NIDE3359	3.4e-114	417.9	Nitrospirae	pal			ko:K03640					ko00000,ko02000	2.C.1.2			Bacteria	3J17Q@40117,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
MAG.T21.41_00097	330214.NIDE3358	5.2e-221	773.9	Bacteria				ko:K01991,ko:K02557,ko:K07161,ko:K07484	ko02026,ko02030,ko02040,map02026,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.18			Bacteria	COG1729@1,COG1729@2,COG4372@1,COG4372@2	NA|NA|NA	Q	Transposase
MAG.T21.41_00098	330214.NIDE3357	3.5e-71	275.0	Nitrospirae	cpoB												Bacteria	3J0RE@40117,COG1729@1,COG1729@2	NA|NA|NA	S	Outer membrane lipoprotein
MAG.T21.41_00099	330214.NIDE3356	2.9e-270	937.6	Nitrospirae	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391		ko:K03572	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	3J0GN@40117,COG0323@1,COG0323@2	NA|NA|NA	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MAG.T21.41_00100	330214.NIDE3355	7.3e-141	506.9	Nitrospirae	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110		R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016				Bacteria	3J0KS@40117,COG0324@1,COG0324@2	NA|NA|NA	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MAG.T21.41_00101	330214.NIDE3354	4.4e-142	510.8	Nitrospirae	mtnP	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2684	Bacteria	3J0HC@40117,COG0005@1,COG0005@2	NA|NA|NA	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates
MAG.T21.41_00102	330214.NIDE3353	3.7e-168	597.4	Nitrospirae	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100		R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000			iAF987.Gmet_2683	Bacteria	3J0ZT@40117,COG0524@1,COG0524@2	NA|NA|NA	G	pfkB family carbohydrate kinase
MAG.T21.41_00103	330214.NIDE3352	3.2e-79	301.6	Nitrospirae	sscB			ko:K02656					ko00000,ko02035,ko02044				Bacteria	3J0V4@40117,COG3063@1,COG3063@2	NA|NA|NA	NU	Tetratricopeptide repeat
MAG.T21.41_00104	330214.NIDE3351	7.5e-116	423.7	Nitrospirae													Bacteria	3J1CJ@40117,COG1426@1,COG1426@2	NA|NA|NA	S	Helix-turn-helix domain
MAG.T21.41_00105	330214.NIDE3350	1.5e-77	295.4	Nitrospirae													Bacteria	3J17C@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T21.41_00106	330214.NIDE3349	5.5e-232	810.4	Nitrospirae													Bacteria	3J0QX@40117,COG4249@1,COG4249@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_00107	330214.NIDE3348	1e-273	949.1	Bacteria				ko:K00612					ko00000,ko01000				Bacteria	COG2192@1,COG2192@2	NA|NA|NA	O	nodulation
MAG.T21.41_00108	330214.NIDE3347	1.4e-212	745.7	Bacteria													Bacteria	COG1287@1,COG1287@2	NA|NA|NA	S	oligosaccharyl transferase activity
MAG.T21.41_00109	330214.NIDE3346	3.1e-110	404.8	Bacteria													Bacteria	COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_00111	330214.NIDE3344	1.2e-227	795.8	Nitrospirae	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0042597,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	3.4.21.107	ko:K04771,ko:K11749	ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0VW@40117,COG0265@1,COG0265@2,COG0750@1,COG0750@2	NA|NA|NA	O	Trypsin
MAG.T21.41_00112	330214.NIDE3343	2.2e-163	581.6	Nitrospirae	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	3J0PJ@40117,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAG.T21.41_00113	330214.NIDE3342	1.1e-183	649.0	Nitrospirae				ko:K03593					ko00000,ko03029,ko03036				Bacteria	3J10K@40117,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MAG.T21.41_00114	330214.NIDE3341	1.3e-224	785.4	Nitrospirae	moeA		2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	3J0MX@40117,COG0303@1,COG0303@2	NA|NA|NA	H	Probable molybdopterin binding domain
MAG.T21.41_00115	330214.NIDE3340	9.7e-86	322.8	Bacteria	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K03750,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100		R09735,R11581	RC03462	ko00000,ko00001,ko01000			iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	Bacteria	COG1763@1,COG1763@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T21.41_00117	330214.NIDE2183	3.2e-59	235.3	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_00119	1320556.AVBP01000022_gene1908	4.5e-155	554.3	Phyllobacteriaceae													Bacteria	1MUIV@1224,2TR5B@28211,43NSU@69277,COG1473@1,COG1473@2	NA|NA|NA	S	Peptidase family M20/M25/M40
MAG.T21.41_00120	1297569.MESS2_310018	3.5e-139	501.5	Phyllobacteriaceae	pepE		3.4.13.9	ko:K01271					ko00000,ko01000,ko01002				Bacteria	1MVJK@1224,2TVVP@28211,43NX6@69277,COG0006@1,COG0006@2	NA|NA|NA	E	Creatinase/Prolidase N-terminal domain
MAG.T21.41_00121	1089551.KE386572_gene1435	3.9e-73	281.6	unclassified Alphaproteobacteria			5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000				Bacteria	1RB05@1224,2U5DB@28211,4BTBP@82117,COG3473@1,COG3473@2	NA|NA|NA	Q	Asp Glu Hydantoin racemase family protein
MAG.T21.41_00122	89187.ISM_04970	5.6e-30	138.3	Alphaproteobacteria	eamA			ko:K15268					ko00000,ko02000	2.A.7.3.2			Bacteria	1MVKG@1224,2U30N@28211,COG0697@1,COG0697@2	NA|NA|NA	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MAG.T21.41_00123	1380391.JIAS01000020_gene1498	9.7e-165	586.3	Rhodospirillales			3.4.13.9,3.5.4.44	ko:K01271,ko:K15783	ko00260,ko01100,map00260,map01100		R09800	RC02661	ko00000,ko00001,ko01000,ko01002				Bacteria	1MWUT@1224,2JRC0@204441,2TT29@28211,COG0006@1,COG0006@2	NA|NA|NA	E	Creatinase/Prolidase N-terminal domain
MAG.T21.41_00124	330214.NIDE0941	3.2e-276	957.6	Bacteria				ko:K07114					ko00000,ko02000	1.A.13.2.2,1.A.13.2.3			Bacteria	COG2304@1,COG2304@2	NA|NA|NA	IU	oxidoreductase activity
MAG.T21.41_00125	330214.NIDE0940	1.1e-69	269.6	Bacteria	srtA		3.4.22.70	ko:K07284					ko00000,ko01000,ko01002,ko01011				Bacteria	COG3764@1,COG3764@2	NA|NA|NA	M	Sortase family
MAG.T21.41_00126	330214.NIDE0939	2.3e-166	592.0	Bacteria													Bacteria	2DKUD@1,30C6A@2	NA|NA|NA	S	Pfam:DUF2029
MAG.T21.41_00129	330214.NIDE1251	7e-60	236.5	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_00131	330214.NIDE1249	3.8e-101	374.4	Nitrospirae	queC		6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100		R09978	RC00959	ko00000,ko00001,ko01000,ko03016			iAF987.Gmet_3075	Bacteria	3J0NP@40117,COG0603@1,COG0603@2	NA|NA|NA	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MAG.T21.41_00132	330214.NIDE1248	2.9e-86	324.7	Nitrospirae				ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	3J0R1@40117,COG1734@1,COG1734@2	NA|NA|NA	T	Prokaryotic dksA/traR C4-type zinc finger
MAG.T21.41_00133	330214.NIDE1247	1.3e-82	312.4	Nitrospirae	apt		2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147				Bacteria	3J14T@40117,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAG.T21.41_00134	330214.NIDE1246	1.3e-145	522.7	Nitrospirae													Bacteria	3J0E4@40117,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T21.41_00135	330214.NIDE1245	3.3e-35	154.1	Bacteria	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120		R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000			iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Bacteria	COG1254@1,COG1254@2	NA|NA|NA	C	Belongs to the acylphosphatase family
MAG.T21.41_00137	330214.NIDE1244	1.2e-173	615.9	Bacteria	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100		R00396	RC00008	ko00000,ko00001,ko01000			iAF987.Gmet_1099	Bacteria	COG0686@1,COG0686@2	NA|NA|NA	E	alanine dehydrogenase activity
MAG.T21.41_00138	330214.NIDE1243	6.8e-57	226.5	Nitrospirae													Bacteria	2CDBX@1,2ZUMJ@2,3J1B0@40117	NA|NA|NA		
MAG.T21.41_00139	330214.NIDE1242	1.7e-57	228.4	Nitrospirae													Bacteria	3J1DT@40117,COG3411@1,COG3411@2	NA|NA|NA	C	Ferredoxin
MAG.T21.41_00140	330214.NIDE1241	7.6e-57	226.5	Nitrospirae													Bacteria	2ETP6@1,33M6W@2,3J18I@40117	NA|NA|NA		
MAG.T21.41_00141	330214.NIDE1240	1.1e-46	192.2	Bacteria													Bacteria	COG2768@1,COG2768@2	NA|NA|NA		
MAG.T21.41_00143	330214.NIDE1238	7.4e-132	476.9	Bacteria	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	COG1562@1,COG1562@2	NA|NA|NA	I	ergosterol biosynthetic process
MAG.T21.41_00144	330214.NIDE1237	6.3e-49	200.3	Bacteria				ko:K14588					ko00000				Bacteria	COG4454@1,COG4454@2	NA|NA|NA		
MAG.T21.41_00145	330214.NIDE1236	3.8e-157	560.8	Nitrospirae	htpX			ko:K03799		M00743			ko00000,ko00002,ko01000,ko01002				Bacteria	3J0QG@40117,COG0501@1,COG0501@2	NA|NA|NA	O	Peptidase family M48
MAG.T21.41_00146	330214.NIDE1235	2.4e-86	325.1	Bacteria	btuE		1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918		R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000			iJN678.slr1992	Bacteria	COG0386@1,COG0386@2	NA|NA|NA	O	Belongs to the glutathione peroxidase family
MAG.T21.41_00151	330214.NIDE0371	8.7e-128	463.0	Nitrospirae	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	Bacteria	3J0J8@40117,COG0224@1,COG0224@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MAG.T21.41_00152	330214.NIDE0372	1.3e-268	931.8	Nitrospirae	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	Bacteria	3J0BN@40117,COG0055@1,COG0055@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MAG.T21.41_00153	330214.NIDE0373	1.9e-66	258.5	Nitrospirae	atpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190	Bacteria	3J0SS@40117,COG0355@1,COG0355@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane
MAG.T21.41_00155	330214.NIDE0376	1.8e-100	372.5	Nitrospirae	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180					ko00000,ko01000,ko03009				Bacteria	3J0HF@40117,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
MAG.T21.41_00157	330214.NIDE0379	8.7e-158	563.1	Nitrospirae	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180					ko00000,ko01000,ko03009				Bacteria	3J0HF@40117,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
MAG.T21.41_00160	330214.NIDE0382	5.4e-69	266.9	Bacteria													Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_00161	330214.NIDE0383	1.6e-130	472.2	Nitrospirae				ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243			ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5			Bacteria	3J1EQ@40117,COG1108@1,COG1108@2	NA|NA|NA	P	ABC 3 transport family
MAG.T21.41_00162	330214.NIDE0384	3e-135	488.0	Nitrospirae	znuC		3.6.3.34	ko:K02013,ko:K09817,ko:K09820	ko02010,map02010	M00240,M00242,M00243			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.15,3.A.1.15.3,3.A.1.15.5			Bacteria	3J15M@40117,COG1121@1,COG1121@2	NA|NA|NA	P	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T21.41_00163	330214.NIDE0385	3.7e-136	491.1	Nitrospirae				ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243			ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5			Bacteria	3J1E3@40117,COG0803@1,COG0803@2	NA|NA|NA	P	Zinc-uptake complex component A periplasmic
MAG.T21.41_00164	330214.NIDE0386	1.1e-175	622.9	Nitrospirae	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170,4.2.1.126	ko:K07106,ko:K09001	ko00520,ko01100,map00520,map01100		R08555	RC00397,RC00746	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	Bacteria	3J126@40117,COG2377@1,COG2377@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MAG.T21.41_00166	330214.NIDE0388	4.2e-68	264.2	Bacteria													Bacteria	COG1729@1,COG1729@2	NA|NA|NA	S	protein trimerization
MAG.T21.41_00167	330214.NIDE0389	2.4e-121	441.8	Bacteria													Bacteria	COG4677@1,COG4677@2	NA|NA|NA	G	pectinesterase activity
MAG.T21.41_00168	330214.NIDE0390	9.9e-145	519.6	Nitrospirae													Bacteria	3J17A@40117,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T21.41_00170	330214.NIDE0393	1.1e-101	376.3	Nitrospirae													Bacteria	3J19T@40117,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
MAG.T21.41_00172	330214.NIDE2524	1.6e-228	798.5	Nitrospirae			1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	3J0IM@40117,COG1249@1,COG1249@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00173	1122611.KB903939_gene305	9.8e-66	258.1	Actinobacteria													Bacteria	2IFW2@201174,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_00174	330214.NIDE2522	0.0	1300.4	Nitrospirae	actA			ko:K13591	ko04112,map04112	M00511			ko00000,ko00001,ko00002,ko02022				Bacteria	3J10M@40117,COG2199@1,COG3706@2,COG5001@1,COG5001@2	NA|NA|NA	T	Putative diguanylate phosphodiesterase
MAG.T21.41_00175	330214.NIDE2521	6.5e-75	287.3	Bacteria													Bacteria	COG5002@1,COG5002@2	NA|NA|NA	T	protein histidine kinase activity
MAG.T21.41_00177	330214.NIDE2519	5.7e-264	916.4	Nitrospirae	rtcB		6.5.1.3	ko:K14415					ko00000,ko01000,ko03016				Bacteria	3J0X0@40117,COG1690@1,COG1690@2	NA|NA|NA	S	tRNA-splicing ligase RtcB
MAG.T21.41_00178	330214.NIDE2518	4.3e-58	230.7	Bacteria													Bacteria	COG1371@1,COG1371@2	NA|NA|NA	J	PFAM Archease protein family (DUF101 UPF0211)
MAG.T21.41_00179	330214.NIDE2517	5.1e-168	597.0	Nitrospirae	sdhB		1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000				Bacteria	3J14K@40117,COG0479@1,COG0479@2	NA|NA|NA	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MAG.T21.41_00180	330214.NIDE2516	7.6e-195	686.4	Nitrospirae	pepP		3.4.11.9,3.4.13.9	ko:K01262,ko:K01271					ko00000,ko01000,ko01002				Bacteria	3J0R0@40117,COG0006@1,COG0006@2	NA|NA|NA	E	Metallopeptidase family M24
MAG.T21.41_00181	330214.NIDE2515	0.0	1909.0	Bacteria				ko:K07290					ko00000	9.B.121			Bacteria	COG2982@1,COG2982@2	NA|NA|NA	M	Protein involved in outer membrane biogenesis
MAG.T21.41_00182	330214.NIDE1635	2.1e-114	418.7	Nitrospirae	ribD	GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	1.1.1.193,3.5.4.26	ko:K01498,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1624,iLJ478.TM1828	Bacteria	3J0H2@40117,COG0117@1,COG0117@2,COG1985@1,COG1985@2	NA|NA|NA	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MAG.T21.41_00183	330214.NIDE1636	6.4e-214	750.0	Bacteria													Bacteria	COG4099@1,COG4099@2	NA|NA|NA	F	phospholipase Carboxylesterase
MAG.T21.41_00184	595460.RRSWK_02441	2.3e-09	69.7	Planctomycetes													Bacteria	2BYHG@1,2IZIW@203682,3208J@2	NA|NA|NA		
MAG.T21.41_00185	330214.NIDE1639	1.4e-201	708.8	Nitrospirae													Bacteria	3J1DQ@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	MFS_1 like family
MAG.T21.41_00187	330214.NIDE1641	3.9e-103	380.9	Nitrospirae	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9,3.5.4.25,4.1.99.12	ko:K00793,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00066,R00425,R07281	RC00293,RC00958,RC00960,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS08950	Bacteria	3J0PR@40117,COG0307@1,COG0307@2	NA|NA|NA	H	Lumazine binding domain
MAG.T21.41_00189	330214.NIDE1643	1.9e-172	611.7	Nitrospirae	acs		6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0BJ@40117,COG0365@1,COG0365@2	NA|NA|NA	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAG.T21.41_00191	330214.NIDE2305	3.8e-164	584.3	Nitrospirae	flhB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820	ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02000,ko02035,ko02044	1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	3J0J3@40117,COG1377@1,COG1377@2	NA|NA|NA	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MAG.T21.41_00192	330214.NIDE2304	6e-119	433.7	Nitrospirae	fliR			ko:K02421,ko:K03228,ko:K13820	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	3J0QA@40117,COG1684@1,COG1684@2	NA|NA|NA	N	Bacterial export proteins, family 1
MAG.T21.41_00193	330214.NIDE2303	2.4e-35	154.5	Nitrospirae	fliQ			ko:K02420,ko:K03227	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	3J0VH@40117,COG1987@1,COG1987@2	NA|NA|NA	N	Role in flagellar biosynthesis
MAG.T21.41_00194	330214.NIDE2302	4.8e-108	397.5	Nitrospirae	fliP	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243		ko:K02419,ko:K03226	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	3J0HW@40117,COG1338@1,COG1338@2	NA|NA|NA	N	Plays a role in the flagellum-specific transport system
MAG.T21.41_00195	330214.NIDE2301	2.3e-33	148.3	Bacteria	fliP			ko:K02418,ko:K02419	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	COG3190@1,COG3190@2	NA|NA|NA	N	flagellar
MAG.T21.41_00196	330214.NIDE2300	1e-49	202.6	Nitrospirae	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944		ko:K02417	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	3J0QM@40117,COG1886@1,COG1886@2	NA|NA|NA	N	Type III flagellar switch regulator (C-ring) FliN C-term
MAG.T21.41_00197	330214.NIDE2299	8.1e-174	616.3	Nitrospirae	fliM			ko:K02416	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Bacteria	3J0CU@40117,COG1868@1,COG1868@2	NA|NA|NA	N	Flagellar motor switch protein FliM
MAG.T21.41_00198	330214.NIDE2298	3.1e-74	284.6	Nitrospirae	fliL			ko:K02415					ko00000,ko02035				Bacteria	3J0QH@40117,COG1580@1,COG1580@2	NA|NA|NA	N	Controls the rotational direction of flagella during chemotaxis
MAG.T21.41_00199	330214.NIDE2297	2.7e-166	591.7	Nitrospirae				ko:K02390	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0IF@40117,COG1749@1,COG1749@2	NA|NA|NA	N	Flagellar basal body protein FlaE
MAG.T21.41_00200	330214.NIDE2296	6.8e-36	156.4	Nitrospirae	flgD	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02389	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0U1@40117,COG1843@1,COG1843@2	NA|NA|NA	N	flagellar hook
MAG.T21.41_00202	330214.NIDE2293	1.4e-55	223.0	Bacteria	ylxF			ko:K02383					ko00000,ko02035				Bacteria	COG3334@1,COG3334@2	NA|NA|NA	S	PFAM MgtE intracellular
MAG.T21.41_00204	330214.NIDE2291	1.1e-231	808.9	Nitrospirae	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412	ko02040,map02040				ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	3J0BV@40117,COG1157@1,COG1157@2	NA|NA|NA	N	ATP synthase alpha/beta family, beta-barrel domain
MAG.T21.41_00205	330214.NIDE2290	2.8e-148	531.6	Bacteria	hrpE			ko:K02411,ko:K03223,ko:K03413	ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070	M00332,M00506,M00660			ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	COG1317@1,COG1317@2,COG2204@1,COG2204@2	NA|NA|NA	N	bacterial-type flagellum organization
MAG.T21.41_00206	330214.NIDE2289	1.4e-165	589.0	Nitrospirae	fliG	GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006928,GO:0006935,GO:0008150,GO:0009288,GO:0009605,GO:0009987,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044403,GO:0044419,GO:0044464,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0071973,GO:0071978,GO:0097588		ko:K02410	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Bacteria	3J0GZ@40117,COG1536@1,COG1536@2	NA|NA|NA	N	FliG middle domain
MAG.T21.41_00207	330214.NIDE2288	6e-182	643.7	Nitrospirae	fliF			ko:K02409	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	3J0A6@40117,COG1766@1,COG1766@2	NA|NA|NA	N	The M ring may be actively involved in energy transduction
MAG.T21.41_00208	89187.ISM_03130	1.9e-11	77.0	Bacteria													Bacteria	293XZ@1,2ZRD0@2	NA|NA|NA		
MAG.T21.41_00209	330214.NIDE1513	8.1e-132	476.5	Nitrospirae	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110		R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006			iLJ478.TM1398	Bacteria	3J0HJ@40117,COG0020@1,COG0020@2	NA|NA|NA	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAG.T21.41_00210	330214.NIDE1512	2.2e-122	445.3	Nitrospirae	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1FV@40117,COG4589@1,COG4589@2	NA|NA|NA	I	Cytidylyltransferase family
MAG.T21.41_00211	330214.NIDE1511	1.2e-195	689.1	Nitrospirae	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	Bacteria	3J0B0@40117,COG0743@1,COG0743@2	NA|NA|NA	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MAG.T21.41_00213	330214.NIDE1468	1.3e-147	529.3	Nitrospirae													Bacteria	3J1AF@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_00219	330214.NIDE1448	1.4e-88	332.8	Bacteria	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340				ko00000,ko00001,ko01000,ko03400				Bacteria	COG0692@1,COG0692@2	NA|NA|NA	L	deaminated base DNA N-glycosylase activity
MAG.T21.41_00221	330214.NIDE3605	1.2e-110	406.0	Bacteria	fkpA		5.2.1.8	ko:K01802,ko:K03772,ko:K03773					ko00000,ko01000,ko03110				Bacteria	COG0545@1,COG0545@2	NA|NA|NA	O	Peptidyl-prolyl cis-trans isomerase
MAG.T21.41_00222	330214.NIDE3604	5.5e-151	540.4	Bacteria	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7,2.5.1.18	ko:K00799,ko:K07393	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2		iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373	Bacteria	COG0435@1,COG0435@2	NA|NA|NA	O	Glutathione S-transferase
MAG.T21.41_00224	330214.NIDE3598	1.1e-156	559.3	Bacteria													Bacteria	COG0702@1,COG0702@2	NA|NA|NA	GM	epimerase
MAG.T21.41_00226	330214.NIDE3595	3e-220	771.2	Bacteria	putP			ko:K03307,ko:K14387	ko04725,ko05231,map04725,map05231				ko00000,ko00001,ko02000	2.A.21,2.A.21.8			Bacteria	COG0591@1,COG0591@2	NA|NA|NA	E	symporter activity
MAG.T21.41_00227	330214.NIDE3593	0.0	1293.1	Nitrospirae													Bacteria	3J10H@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00228	330214.NIDE0473	1.1e-69	269.2	Bacteria													Bacteria	COG4307@1,COG4307@2	NA|NA|NA	T	Protein conserved in bacteria
MAG.T21.41_00229	330214.NIDE0474	5e-182	643.7	Bacteria	ddlB1		6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011				Bacteria	COG1181@1,COG1181@2	NA|NA|NA	F	Belongs to the D-alanine--D-alanine ligase family
MAG.T21.41_00232	330214.NIDE0478	5.5e-104	383.6	Nitrospirae	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	3J118@40117,COG0588@1,COG0588@2	NA|NA|NA	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MAG.T21.41_00234	330214.NIDE0482	2.5e-99	368.2	Bacteria	pilA			ko:K02650	ko02020,map02020				ko00000,ko00001,ko02035,ko02044	3.A.15.2			Bacteria	COG4969@1,COG4969@2	NA|NA|NA	NU	cell adhesion
MAG.T21.41_00235	330214.NIDE0483	9e-207	726.1	Nitrospirae	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iAF987.Gmet_0204,iHN637.CLJU_RS10560	Bacteria	3J0AB@40117,COG4992@1,COG4992@2	NA|NA|NA	E	Aminotransferase class-III
MAG.T21.41_00236	330214.NIDE0484	3.2e-162	577.8	Nitrospirae	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.11,2.1.3.3,2.1.3.6,2.1.3.9,2.7.2.2	ko:K00611,ko:K00926,ko:K09065,ko:K13043,ko:K13252	ko00220,ko00230,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00220,map00230,map00910,map01100,map01110,map01120,map01130,map01200,map01230	M00029,M00844,M00845	R00150,R01395,R01398,R07245,R08937	RC00002,RC00043,RC00096,RC02803,RC02804	ko00000,ko00001,ko00002,ko01000			iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iLJ478.TM1097,iY75_1357.Y75_RS01410	Bacteria	3J0G7@40117,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MAG.T21.41_00237	330214.NIDE0485	1.4e-223	781.9	Nitrospirae	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147			iJN678.argG,iSB619.SA_RS04675	Bacteria	3J0BU@40117,COG0137@1,COG0137@2	NA|NA|NA	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily
MAG.T21.41_00238	330214.NIDE0486	2.8e-239	834.3	Nitrospirae	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147			iJN678.argH	Bacteria	3J0EN@40117,COG0165@1,COG0165@2	NA|NA|NA	E	Argininosuccinate lyase C-terminal
MAG.T21.41_00240	330214.NIDE0488	1.1e-215	755.7	Nitrospirae	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.1.129,3.4.16.4,4.1.1.20	ko:K01586,ko:K05366	ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000,ko01003,ko01011		GT51	iLJ478.TM1517	Bacteria	3J0CR@40117,COG0019@1,COG0019@2	NA|NA|NA	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MAG.T21.41_00241	330214.NIDE0489	2.2e-146	525.0	Nitrospirae	dapA		4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0CF@40117,COG0329@1,COG0329@2	NA|NA|NA	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAG.T21.41_00242	330214.NIDE0490	1.3e-137	495.7	Nitrospirae	dapB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215,ko:K03546	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000,ko03400			iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035	Bacteria	3J0IJ@40117,COG0289@1,COG0289@2	NA|NA|NA	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MAG.T21.41_00243	330214.NIDE0491	1.8e-19	101.7	Bacteria	tmoA	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1	ko:K00688,ko:K15760,ko:K16157,ko:K16242,ko:K18223,ko:K22353,ko:K22357	ko00361,ko00362,ko00500,ko00623,ko00625,ko00640,ko00680,ko01100,ko01110,ko01120,ko01200,ko01220,ko02026,ko04217,ko04910,ko04922,ko04931,map00361,map00362,map00500,map00623,map00625,map00640,map00680,map01100,map01110,map01120,map01200,map01220,map02026,map04217,map04910,map04922,map04931	M00174,M00538,M00548	R01142,R02111,R02550,R03560,R03562,R03608,R05444,R05666,R10042,R10043,R10702,R11901	RC00046,RC00173,RC00269,RC00490,RC01383,RC03249	ko00000,ko00001,ko00002,ko01000		GT35		Bacteria	COG3350@1,COG3350@2	NA|NA|NA	T	monooxygenase activity
MAG.T21.41_00245	330214.NIDE0493	1.5e-112	412.1	Nitrospirae	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0YY@40117,COG0176@1,COG0176@2	NA|NA|NA	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MAG.T21.41_00246	330214.NIDE0494	1.2e-108	399.4	Bacteria	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	COG1573@1,COG1573@2	NA|NA|NA	L	deaminated base DNA N-glycosylase activity
MAG.T21.41_00247	330214.NIDE0495	2.1e-170	605.1	Nitrospirae	mltD_2												Bacteria	3J0J4@40117,COG0741@1,COG0741@2	NA|NA|NA	M	Lysin motif
MAG.T21.41_00248	330214.NIDE0496	3.2e-181	641.3	Nitrospirae	ttuD		2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000				Bacteria	3J16T@40117,COG2379@1,COG2379@2	NA|NA|NA	H	MOFRL family
MAG.T21.41_00249	330214.NIDE0497	0.0	1153.3	Nitrospirae	ppsA2		2.7.1.40,2.7.9.2	ko:K00873,ko:K01007	ko00010,ko00230,ko00620,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map00680,map00720,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00173,M00374	R00199,R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	3J0QY@40117,COG0574@1,COG0574@2,COG3848@1,COG3848@2	NA|NA|NA	G	PEP-utilising enzyme, mobile domain
MAG.T21.41_00250	330214.NIDE0498	4.2e-187	661.0	Nitrospirae	rmuC			ko:K09760					ko00000				Bacteria	3J15T@40117,COG1322@1,COG1322@2	NA|NA|NA	S	RmuC family
MAG.T21.41_00251	330214.NIDE0499	1.5e-55	222.2	Bacteria	XK27_03185			ko:K16785	ko02010,map02010	M00582			ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	COG4696@1,COG4696@2	NA|NA|NA	J	Protein conserved in bacteria
MAG.T21.41_00253	330214.NIDE0501	2.9e-119	434.9	Nitrospirae	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KR@40117,COG0414@1,COG0414@2	NA|NA|NA	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MAG.T21.41_00254	330214.NIDE0502	5.5e-82	310.5	Nitrospirae	folK		2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0041	Bacteria	3J19N@40117,COG0801@1,COG0801@2	NA|NA|NA	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
MAG.T21.41_00255	330214.NIDE0503	1.2e-219	768.8	Nitrospirae	dapL		2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0G2@40117,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase class I and II
MAG.T21.41_00256	330214.NIDE0504	5.6e-137	494.2	Bacteria				ko:K13663					ko00000,ko01000				Bacteria	COG1835@1,COG1835@2	NA|NA|NA	I	transferase activity, transferring acyl groups other than amino-acyl groups
MAG.T21.41_00258	330214.NIDE0507	5.7e-139	500.4	Nitrospirae	wzm			ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103			Bacteria	3J1DI@40117,COG1682@1,COG1682@2	NA|NA|NA	U	ABC-2 type transporter
MAG.T21.41_00259	330214.NIDE0508	1.3e-206	725.7	Nitrospirae			3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103			Bacteria	3J142@40117,COG1134@1,COG1134@2	NA|NA|NA	GM	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00262	330214.NIDE0511	5.7e-113	413.7	Bacteria	pmtA		2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00266	330214.NIDE0515	2.3e-73	282.0	Bacteria													Bacteria	COG0406@1,COG0406@2	NA|NA|NA	G	alpha-ribazole phosphatase activity
MAG.T21.41_00267	330214.NIDE0516	1.8e-123	449.1	Bacteria	hcf136												Bacteria	COG4447@1,COG4447@2	NA|NA|NA	S	cellulose binding
MAG.T21.41_00268	330214.NIDE0517	8.9e-152	543.5	Nitrospirae	attH												Bacteria	3J19I@40117,COG5621@1,COG5621@2	NA|NA|NA	S	Lipocalin-like domain
MAG.T21.41_00269	330214.NIDE0518	4.9e-117	427.2	Nitrospirae	lonD		3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	3J13Q@40117,COG2802@1,COG2802@2	NA|NA|NA	S	ATP-dependent protease La (LON) substrate-binding domain
MAG.T21.41_00270	330214.NIDE0519	2.6e-164	584.7	Nitrospirae	ccmA			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	3J0JF@40117,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T21.41_00271	330214.NIDE0520	6.6e-134	483.4	Bacteria	ycf38			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG0842@1,COG0842@2	NA|NA|NA	V	Transport permease protein
MAG.T21.41_00272	330214.NIDE0521	3.1e-145	521.2	Bacteria													Bacteria	COG2912@1,COG2912@2	NA|NA|NA	P	Transglutaminase-like superfamily
MAG.T21.41_00273	330214.NIDE0522	1.4e-125	455.7	Bacteria													Bacteria	COG1234@1,COG1234@2	NA|NA|NA	L	tRNA 3'-trailer cleavage
MAG.T21.41_00274	639283.Snov_1755	1.5e-51	211.1	Xanthobacteraceae	kpsE			ko:K10107	ko02010,map02010	M00249			ko00000,ko00001,ko00002,ko02000	3.A.1.101			Bacteria	1R3ZY@1224,2U0I2@28211,3F1I9@335928,COG3524@1,COG3524@2	NA|NA|NA	M	COG3524 Capsule polysaccharide export protein
MAG.T21.41_00279	330214.NIDE1289	0.0	1439.5	Nitrospirae	glgP		2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R01555,R02111	RC00049	ko00000,ko00001,ko01000		GH65,GT35		Bacteria	3J0W1@40117,COG0058@1,COG0058@2	NA|NA|NA	G	Carbohydrate phosphorylase
MAG.T21.41_00280	330214.NIDE1288	1.2e-48	201.1	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00281	522772.Dacet_1459	2.8e-28	131.0	Deferribacteres	lcrS			ko:K07497					ko00000				Bacteria	2GGNA@200930,COG2963@1,COG2963@2	NA|NA|NA	L	PFAM transposase IS3 IS911 family protein
MAG.T21.41_00285	330214.NIDE2705	1.5e-11	74.7	Bacteria				ko:K07497					ko00000				Bacteria	COG2801@1,COG2801@2	NA|NA|NA	L	transposition
MAG.T21.41_00286	330214.NIDE1286	4e-113	414.5	Nitrospirae													Bacteria	3J1E2@40117,COG1413@1,COG1413@2	NA|NA|NA	C	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00288	330214.NIDE1284	8.1e-85	320.1	Bacteria	rlpA			ko:K03642					ko00000				Bacteria	COG0797@1,COG0797@2	NA|NA|NA	M	peptidoglycan binding
MAG.T21.41_00291	330214.NIDE1279	2.5e-159	568.2	Bacteria	ccmA		3.6.3.7	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.115			Bacteria	COG1131@1,COG1131@2	NA|NA|NA	V	ATPase activity
MAG.T21.41_00292	330214.NIDE1278	7.9e-124	449.9	Bacteria	yxlG			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG1277@1,COG1277@2	NA|NA|NA		
MAG.T21.41_00293	330214.NIDE1277	1.5e-262	911.8	Bacteria	gldG			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG3225@1,COG3225@2	NA|NA|NA		
MAG.T21.41_00294	706587.Desti_2984	9.1e-22	111.7	Syntrophobacterales													Bacteria	1N8HX@1224,2DN50@1,2MS7V@213462,2WS94@28221,32VJ4@2,42VGC@68525	NA|NA|NA	S	Domain of unknown function (DUF4340)
MAG.T21.41_00297	330214.NIDE1274	2.2e-196	691.4	Nitrospirae													Bacteria	3J1FQ@40117,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_00298	330214.NIDE1273	2.6e-33	147.9	Bacteria				ko:K02806	ko02060,map02060				ko00000,ko00001,ko01000,ko02000				Bacteria	COG3311@1,COG3311@2	NA|NA|NA	K	DNA excision
MAG.T21.41_00299	330214.NIDE1784	2.5e-101	375.2	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00302	338963.Pcar_1976	4.9e-102	378.3	Desulfuromonadales													Bacteria	1N5Z3@1224,2CGDQ@1,2WVDK@28221,32VRQ@2,43057@68525,43V2T@69541	NA|NA|NA		
MAG.T21.41_00303	330214.NIDE3247	2.5e-52	212.2	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00304	330214.NIDE3247	3.9e-47	194.9	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00305	215803.DB30_2740	4.1e-49	201.4	Myxococcales	sodA		1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016				ko00000,ko00001,ko01000				Bacteria	1R4Z3@1224,2WMPC@28221,2YVDJ@29,42QV7@68525,COG0605@1,COG0605@2	NA|NA|NA	C	Iron/manganese superoxide dismutases, C-terminal domain
MAG.T21.41_00307	1282360.ABAC460_19100	4e-12	78.2	Caulobacterales													Bacteria	1NMH1@1224,2KGWZ@204458,2U9D8@28211,COG0517@1,COG0517@2	NA|NA|NA	S	CBS domain
MAG.T21.41_00309	402626.Rpic_0139	2.5e-63	248.4	Burkholderiaceae	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	1K074@119060,1RAQ8@1224,2VQHR@28216,COG2193@1,COG2193@2	NA|NA|NA	P	Ferritin, Dps family protein
MAG.T21.41_00310	1150469.RSPPHO_00671	1.9e-14	86.3	Rhodospirillales				ko:K06217					ko00000				Bacteria	1MWMU@1224,2JPXI@204441,2TSYC@28211,COG1702@1,COG1702@2	NA|NA|NA	T	COG1702 Phosphate starvation-inducible protein PhoH
MAG.T21.41_00311	1150469.RSPPHO_00671	5.4e-10	70.9	Rhodospirillales				ko:K06217					ko00000				Bacteria	1MWMU@1224,2JPXI@204441,2TSYC@28211,COG1702@1,COG1702@2	NA|NA|NA	T	COG1702 Phosphate starvation-inducible protein PhoH
MAG.T21.41_00312	195105.CN97_03410	1.1e-82	312.8	Alphaproteobacteria	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277		ko:K03619,ko:K07152					ko00000,ko03029				Bacteria	1RHJ8@1224,2U9DV@28211,COG1999@1,COG1999@2	NA|NA|NA	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems
MAG.T21.41_00313	1121271.AUCM01000016_gene2645	6.9e-70	270.0	Alphaproteobacteria				ko:K09796					ko00000,ko03110				Bacteria	1MZ3M@1224,2UBUR@28211,COG2847@1,COG2847@2	NA|NA|NA	P	Protein conserved in bacteria
MAG.T21.41_00314	195105.CN97_03420	1.6e-71	275.8	Alphaproteobacteria	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277		ko:K03619,ko:K07152					ko00000,ko03029				Bacteria	1RHJ8@1224,2U0Q3@28211,COG1999@1,COG1999@2	NA|NA|NA	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems
MAG.T21.41_00316	195105.CN97_03430	7.7e-123	446.8	Alphaproteobacteria	lnt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K03820					ko00000,ko01000		GT2	iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590	Bacteria	1MUBU@1224,2TQRC@28211,COG0815@1,COG0815@2	NA|NA|NA	M	Transfers the fatty acyl group on membrane lipoproteins
MAG.T21.41_00318	518766.Rmar_2740	2.1e-11	76.3	Bacteroidetes Order II. Incertae sedis													Bacteria	1FJBI@1100069,292MF@1,30IPY@2,4P6CM@976	NA|NA|NA	S	Protein of unknown function (DUF3047)
MAG.T21.41_00320	330214.NIDE3300	3.9e-162	577.4	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00321	330214.NIDE3299	5.3e-143	513.8	Nitrospirae			1.14.99.50	ko:K18912	ko00340,map00340		R11013	RC03323,RC03324	ko00000,ko00001,ko01000				Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00325	330214.NIDE3296	0.0	1247.6	Bacteria			1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6			Bacteria	COG1271@1,COG1271@2	NA|NA|NA	C	aerobic electron transport chain
MAG.T21.41_00326	330214.NIDE3295	2.6e-239	834.3	Bacteria	ccoP			ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_00327	330214.NIDE3294	5.4e-200	703.4	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_00328	330214.NIDE3293	0.0	1190.6	Bacteria				ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_00329	330214.NIDE3292	5.1e-65	254.2	Nitrospirae	mobA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100		R11581		ko00000,ko00001,ko01000				Bacteria	3J1C5@40117,COG0746@1,COG0746@2	NA|NA|NA	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MAG.T21.41_00330	330214.NIDE3291	6.2e-87	327.8	Nitrospirae				ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	3J1E5@40117,COG0859@1,COG0859@2	NA|NA|NA	M	Glycosyltransferase family 9 (heptosyltransferase)
MAG.T21.41_00331	330214.NIDE3290	2.3e-283	981.1	Nitrospirae	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iAF987.Gmet_1434	Bacteria	3J0A8@40117,COG0018@1,COG0018@2	NA|NA|NA	J	Arginyl tRNA synthetase N terminal dom
MAG.T21.41_00332	330214.NIDE3289	2.1e-208	731.5	Nitrospirae	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773			R03789,R10209	RC00063	ko00000,ko01000,ko03016			iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	Bacteria	3J0DU@40117,COG0343@1,COG0343@2	NA|NA|NA	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MAG.T21.41_00333	330214.NIDE3288	3.7e-43	180.6	Nitrospirae	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	3J0UB@40117,COG1862@1,COG1862@2	NA|NA|NA	U	Preprotein translocase subunit
MAG.T21.41_00334	330214.NIDE3287	3.6e-291	1006.9	Nitrospirae	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	3J09Z@40117,COG0342@1,COG0342@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T21.41_00335	330214.NIDE3286	3.6e-147	527.7	Nitrospirae	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	3J0GM@40117,COG0341@1,COG0341@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T21.41_00336	330214.NIDE3284	0.0	1885.5	Nitrospirae			2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J117@40117,COG3829@1,COG3829@2,COG4191@1,COG4191@2,COG5000@1,COG5000@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_00337	330214.NIDE3283	1.6e-218	765.4	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_00338	330214.NIDE3282	1.9e-94	352.8	Bacteria													Bacteria	COG2319@1,COG2319@2	NA|NA|NA	S	anaphase-promoting complex binding
MAG.T21.41_00339	330214.NIDE3281	4.5e-199	700.3	Bacteria													Bacteria	2AKTZ@1,31BM1@2	NA|NA|NA		
MAG.T21.41_00340	330214.NIDE3280	2.5e-96	358.2	Bacteria	napG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02573					ko00000				Bacteria	COG0437@1,COG0437@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
MAG.T21.41_00341	330214.NIDE3279	1.5e-183	648.7	Bacteria													Bacteria	COG3381@1,COG3381@2	NA|NA|NA	S	protein complex oligomerization
MAG.T21.41_00342	330214.NIDE3278	2.5e-183	647.9	Bacteria	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373,ko:K17052	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Bacteria	COG2180@1,COG2180@2	NA|NA|NA	C	chaperone-mediated protein complex assembly
MAG.T21.41_00343	330214.NIDE3276	0.0	1169.8	Bacteria													Bacteria	COG1032@1,COG1032@2	NA|NA|NA	C	radical SAM domain protein
MAG.T21.41_00346	330214.NIDE3273	2.6e-27	127.9	Nitrospirae	tatA			ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	3J1A4@40117,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MAG.T21.41_00347	330214.NIDE3272	3.8e-232	810.4	Nitrospirae			2.7.11.1	ko:K08884					ko00000,ko01000,ko01001				Bacteria	3J19W@40117,COG3391@1,COG3391@2	NA|NA|NA	S	NHL repeat
MAG.T21.41_00348	330214.NIDE3271	9.4e-147	526.2	Bacteria	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373,ko:K17052	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Bacteria	COG2180@1,COG2180@2	NA|NA|NA	C	chaperone-mediated protein complex assembly
MAG.T21.41_00350	330214.NIDE3269	3.7e-230	803.9	Bacteria													Bacteria	COG3005@1,COG3005@2	NA|NA|NA	C	denitrification pathway
MAG.T21.41_00351	330214.NIDE3268	8.3e-216	756.1	Bacteria													Bacteria	COG3005@1,COG3005@2	NA|NA|NA	C	denitrification pathway
MAG.T21.41_00353	330214.NIDE3266	0.0	1139.0	Bacteria	hppA		3.6.1.1	ko:K15987	ko00190,map00190				ko00000,ko00001,ko01000	3.A.10.1			Bacteria	COG3808@1,COG3808@2	NA|NA|NA	C	hydrogen-translocating pyrophosphatase activity
MAG.T21.41_00355	330214.NIDE3264	7.8e-281	972.6	Nitrospirae	recJ			ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0PF@40117,COG0608@1,COG0608@2	NA|NA|NA	L	DHH family
MAG.T21.41_00356	330214.NIDE3263	0.0	1385.9	Nitrospirae	relA		2.7.6.5	ko:K00951	ko00230,map00230		R00429	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	3J0CX@40117,COG0317@1,COG0317@2	NA|NA|NA	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MAG.T21.41_00357	330214.NIDE3262	4.7e-213	747.3	Bacteria				ko:K05802					ko00000,ko02000	1.A.23.1.1			Bacteria	COG0664@1,COG0664@2,COG3264@1,COG3264@2	NA|NA|NA	M	cellular water homeostasis
MAG.T21.41_00358	330214.NIDE3261	9.7e-70	269.6	Bacteria				ko:K09005					ko00000				Bacteria	COG1430@1,COG1430@2	NA|NA|NA	S	Uncharacterized ACR, COG1430
MAG.T21.41_00360	330214.NIDE3258	1.5e-77	295.8	Nitrospirae	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000				Bacteria	3J192@40117,COG0655@1,COG0655@2	NA|NA|NA	S	NADPH-dependent FMN reductase
MAG.T21.41_00361	330214.NIDE3257	8.5e-25	119.0	Bacteria	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K02192					ko00000				Bacteria	COG2906@1,COG2906@2	NA|NA|NA	P	2 iron, 2 sulfur cluster binding
MAG.T21.41_00362	330214.NIDE3236	1.6e-265	921.4	Nitrospirae	narH	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9			Bacteria	3J1FU@40117,COG1140@1,COG1140@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00363	330214.NIDE3237	5e-175	620.2	Bacteria	ddhA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.17.99.2,1.7.5.1,1.8.2.4	ko:K00370,ko:K10700,ko:K16964,ko:K17050	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9			Bacteria	COG0243@1,COG0243@2	NA|NA|NA	C	molybdopterin cofactor binding
MAG.T21.41_00365	330214.NIDE3169	6.9e-75	286.6	Bacteria	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	COG2193@1,COG2193@2	NA|NA|NA	P	ferroxidase activity
MAG.T21.41_00366	330214.NIDE3170	2.6e-197	694.5	Nitrospirae	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772		ko:K06942					ko00000,ko03009				Bacteria	3J0II@40117,COG0012@1,COG0012@2	NA|NA|NA	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MAG.T21.41_00367	330214.NIDE3173	1.3e-145	522.7	Bacteria			3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110		GH20		Bacteria	COG3525@1,COG3525@2	NA|NA|NA	G	beta-N-acetylhexosaminidase activity
MAG.T21.41_00368	330214.NIDE3174	2.4e-61	242.3	Bacteria													Bacteria	2E3YM@1,32YVJ@2	NA|NA|NA		
MAG.T21.41_00371	330214.NIDE3176	2.6e-175	621.3	Nitrospirae	galE		5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0J5@40117,COG1087@1,COG1087@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
MAG.T21.41_00372	330214.NIDE3177	8.9e-124	449.9	Bacteria				ko:K05516					ko00000,ko03036,ko03110				Bacteria	COG0484@1,COG0484@2,COG1948@1,COG1948@2	NA|NA|NA	L	resolution of meiotic recombination intermediates
MAG.T21.41_00373	330214.NIDE3178	2.7e-235	821.2	Bacteria													Bacteria	COG0464@1,COG0464@2	NA|NA|NA	O	ATPase activity
MAG.T21.41_00374	1317124.DW2_05185	2.6e-08	67.4	Thioclava													Bacteria	1MYB8@1224,2TQV5@28211,2XN1V@285107,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_00375	330214.NIDE3181	5.4e-130	470.7	Bacteria	yihR	GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2017@1,COG2017@2	NA|NA|NA	G	converts alpha-aldose to the beta-anomer
MAG.T21.41_00376	330214.NIDE3182	1.3e-211	742.3	Nitrospirae	pfp	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135	2.7.1.11,2.7.1.90	ko:K00850,ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019				Bacteria	3J0Y1@40117,COG0205@1,COG0205@2	NA|NA|NA	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
MAG.T21.41_00377	1305732.JAGG01000001_gene1613	1.4e-17	95.9	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00378	1173026.Glo7428_2080	8.4e-82	312.4	Cyanobacteria				ko:K03406,ko:K21009	ko02020,ko02025,ko02030,map02020,map02025,map02030				ko00000,ko00001,ko02035				Bacteria	1G1Z5@1117,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4251@1,COG4251@2,COG5278@1,COG5278@2	NA|NA|NA	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
MAG.T21.41_00380	78245.Xaut_2906	7.9e-11	72.4	Xanthobacteraceae				ko:K07483					ko00000				Bacteria	1PE1X@1224,2V5Q9@28211,3F23G@335928,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
MAG.T21.41_00381	517417.Cpar_1358	3.8e-91	342.8	Bacteria													Bacteria	2E9D7@1,333KS@2	NA|NA|NA		
MAG.T21.41_00382	1288494.EBAPG3_19400	7.7e-60	237.7	Nitrosomonadales			3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Bacteria	1PSEB@1224,2VUDB@28216,373SI@32003,COG0412@1,COG0412@2	NA|NA|NA	Q	Dienelactone hydrolase
MAG.T21.41_00383	261292.Nit79A3_2268	1.5e-73	283.1	Proteobacteria													Bacteria	1N9HN@1224,COG4782@1,COG4782@2	NA|NA|NA	S	Alpha/beta hydrolase of unknown function (DUF900)
MAG.T21.41_00384	261292.Nit79A3_2267	2.4e-59	235.7	Proteobacteria													Bacteria	1NFMY@1224,2E84E@1,332I4@2	NA|NA|NA		
MAG.T21.41_00386	330214.NIDE1150	0.0	1408.7	Nitrospirae	cca		2.7.7.19,2.7.7.72,3.1.13.3,3.1.3.7	ko:K00970,ko:K00974,ko:K06881	ko00920,ko01100,ko01120,ko03013,ko03018,map00920,map01100,map01120,map03013,map03018		R00188,R00508,R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019,ko03400				Bacteria	3J0NX@40117,COG0517@1,COG0517@2,COG0617@1,COG0617@2,COG0618@1,COG0618@2	NA|NA|NA	J	Probable RNA and SrmB- binding site of polymerase A
MAG.T21.41_00388	330214.NIDE1152	5.3e-125	454.1	Bacteria	kipA		3.5.1.54,6.3.4.6	ko:K01457,ko:K01941,ko:K06350	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120		R00005,R00774	RC00378,RC02756	ko00000,ko00001,ko01000				Bacteria	COG1984@1,COG1984@2	NA|NA|NA	E	allophanate hydrolase subunit 2
MAG.T21.41_00389	330214.NIDE1153	1.5e-98	365.9	Bacteria	ybgL			ko:K07160					ko00000				Bacteria	COG1540@1,COG1540@2	NA|NA|NA	S	5-oxoprolinase (ATP-hydrolyzing) activity
MAG.T21.41_00390	330214.NIDE1154	9.6e-70	270.0	Bacteria	kipI		3.5.1.54	ko:K01457,ko:K06351,ko:K07160	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120		R00005	RC02756	ko00000,ko00001,ko01000				Bacteria	COG2049@1,COG2049@2	NA|NA|NA	E	5-oxoprolinase (ATP-hydrolyzing) activity
MAG.T21.41_00391	330214.NIDE1155	2.4e-205	721.5	Nitrospirae													Bacteria	3J171@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Sugar (and other) transporter
MAG.T21.41_00392	330214.NIDE1156	1.6e-102	379.0	Bacteria	dnaJ2			ko:K03686,ko:K05516					ko00000,ko03029,ko03036,ko03110				Bacteria	COG0484@1,COG0484@2	NA|NA|NA	O	heat shock protein binding
MAG.T21.41_00393	330214.NIDE1157	2.7e-187	661.4	Bacteria													Bacteria	COG1228@1,COG1228@2	NA|NA|NA	Q	imidazolonepropionase activity
MAG.T21.41_00394	330214.NIDE1159	4.5e-106	390.6	Bacteria				ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	COG4191@1,COG4191@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_00395	330214.NIDE1160	3.1e-170	604.7	Nitrospirae	spt		2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0FC@40117,COG0075@1,COG0075@2	NA|NA|NA	E	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00396	330214.NIDE1161	3.3e-235	820.8	Bacteria			1.16.3.1	ko:K03594,ko:K07052	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	COG1266@1,COG1266@2,COG1633@1,COG1633@2	NA|NA|NA	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MAG.T21.41_00397	330214.NIDE3333	4.6e-71	274.2	Nitrospirae													Bacteria	3J0VE@40117,COG1396@1,COG1396@2,COG1917@1,COG1917@2	NA|NA|NA	K	Cupin domain
MAG.T21.41_00398	330214.NIDE1162	1e-100	373.2	Bacteria	yeeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.5.5.1	ko:K00311					ko00000,ko01000				Bacteria	COG0451@1,COG0451@2	NA|NA|NA	GM	ADP-glyceromanno-heptose 6-epimerase activity
MAG.T21.41_00399	330214.NIDE1163	1.2e-160	572.8	Bacteria			2.7.13.3	ko:K07683	ko02020,map02020	M00483			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_00400	330214.NIDE1164	1.3e-108	399.1	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00401	330214.NIDE1165	1e-61	242.7	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00403	330214.NIDE1167	0.0	2464.5	Bacteria	lhr			ko:K03724					ko00000,ko01000,ko03400				Bacteria	COG1201@1,COG1201@2	NA|NA|NA	L	RNA secondary structure unwinding
MAG.T21.41_00404	330214.NIDE1168	9.7e-131	473.0	Bacteria													Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_00407	330214.NIDE1172	4.5e-207	727.2	Bacteria	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347,ko:K21163	ko01059,ko01130,map01059,map01130	M00824			ko00000,ko00001,ko00002,ko01000				Bacteria	COG1805@1,COG1805@2,COG4402@1,COG4402@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2330)
MAG.T21.41_00408	330214.NIDE1172	2.2e-109	402.1	Bacteria	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347,ko:K21163	ko01059,ko01130,map01059,map01130	M00824			ko00000,ko00001,ko00002,ko01000				Bacteria	COG1805@1,COG1805@2,COG4402@1,COG4402@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2330)
MAG.T21.41_00409	153948.NAL212_1039	1.2e-29	136.7	Nitrosomonadales													Bacteria	1RK5Z@1224,2BP06@1,2WBIA@28216,32HQG@2,3736M@32003	NA|NA|NA		
MAG.T21.41_00411	330214.NIDE1182	2.7e-92	345.9	Bacteria													Bacteria	2E7Z1@1,332DD@2	NA|NA|NA		
MAG.T21.41_00412	330214.NIDE1183	7.8e-72	276.6	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_00413	1472716.KBK24_0103470	4.8e-71	273.9	Burkholderiaceae													Bacteria	1K4FR@119060,1R3ZM@1224,2VWH4@28216,COG1715@1,COG1715@2	NA|NA|NA	V	Restriction endonuclease
MAG.T21.41_00414	85643.Tmz1t_0935	3.7e-76	291.2	Rhodocyclales													Bacteria	1MZZB@1224,2KYZP@206389,2W32V@28216,COG4195@1,COG4195@2	NA|NA|NA	S	Poly-gamma-glutamate hydrolase
MAG.T21.41_00416	1396418.BATQ01000155_gene2495	1.6e-32	146.0	Verrucomicrobia													Bacteria	46TM3@74201,COG1520@1,COG1520@2	NA|NA|NA	S	PQQ-like domain
MAG.T21.41_00417	330214.NIDE3164	3.1e-51	208.0	Bacteria				ko:K07006					ko00000				Bacteria	COG3576@1,COG3576@2	NA|NA|NA	S	Pyridoxamine 5'-phosphate oxidase
MAG.T21.41_00418	330214.NIDE3163	1.6e-204	718.8	Bacteria	frgC			ko:K07714	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_00419	330214.NIDE3162	1.6e-243	848.6	Bacteria				ko:K14978	ko02020,map02020	M00663			ko00000,ko00001,ko00002,ko01001,ko02022				Bacteria	COG3850@1,COG3850@2,COG4251@1,COG4251@2	NA|NA|NA	T	phosphorelay sensor kinase activity
MAG.T21.41_00421	330214.NIDE3158	2.9e-108	398.3	Bacteria				ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	COG0725@1,COG0725@2	NA|NA|NA	P	tungstate binding
MAG.T21.41_00422	330214.NIDE3157	1.8e-266	924.9	Bacteria													Bacteria	COG3746@1,COG3746@2	NA|NA|NA		
MAG.T21.41_00423	330214.NIDE3156	8.3e-128	463.8	Nitrospirae													Bacteria	3J13A@40117,COG1476@1,COG1476@2,COG1910@1,COG1910@2	NA|NA|NA	K	PBP superfamily domain
MAG.T21.41_00424	330214.NIDE3155	6.1e-77	294.3	Bacteria				ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	COG0725@1,COG0725@2	NA|NA|NA	P	tungstate binding
MAG.T21.41_00430	330214.NIDE1263	6.9e-99	367.1	Bacteria													Bacteria	29A8R@1,2ZX9N@2	NA|NA|NA		
MAG.T21.41_00432	330214.NIDE1261	3.8e-55	221.1	Bacteria													Bacteria	COG0784@1,COG0784@2	NA|NA|NA	T	Response regulator, receiver
MAG.T21.41_00433	330214.NIDE1259	5.7e-114	418.3	Bacteria													Bacteria	2AKRW@1,31BIT@2	NA|NA|NA		
MAG.T21.41_00434	330214.NIDE1258	1e-40	172.2	Bacteria													Bacteria	COG1522@1,COG1522@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_00436	330214.NIDE1256	3.3e-229	800.8	Nitrospirae	nla28			ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	3J10B@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Sigma-54 interaction domain
MAG.T21.41_00437	330214.NIDE1255	5.6e-39	166.8	Nitrospirae			2.7.13.3	ko:K07709	ko02020,map02020	M00499			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J14D@40117,COG4191@1,COG4191@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_00438	631362.Thi970DRAFT_03470	2.9e-27	127.9	Gammaproteobacteria													Bacteria	1NKQ1@1224,1SVTD@1236,2EKIU@1,33E8R@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_00439	543728.Vapar_5912	2.1e-179	635.2	Comamonadaceae			2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Bacteria	1PR6E@1224,2VJK8@28216,4AE8A@80864,COG3550@1,COG3550@2	NA|NA|NA	S	PFAM HipA domain protein
MAG.T21.41_00440	365044.Pnap_0002	6.1e-101	374.0	Comamonadaceae													Bacteria	1NHIB@1224,2VNF7@28216,4AEH6@80864,COG3440@1,COG3440@2	NA|NA|NA	V	Domain of unknown function (DUF3883)
MAG.T21.41_00441	543728.Vapar_0855	1.6e-23	116.7	Comamonadaceae													Bacteria	1N5Z4@1224,2VVH7@28216,4AF4M@80864,COG1432@1,COG1432@2	NA|NA|NA	S	NYN domain
MAG.T21.41_00442	330214.NIDE1205	4.1e-77	293.9	Nitrospirae	pycA		6.3.4.14,6.4.1.1,6.4.1.2,6.4.1.7	ko:K01959,ko:K01961,ko:K20141	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0YP@40117,COG0439@1,COG0439@2	NA|NA|NA	I	Biotin carboxylase C-terminal domain
MAG.T21.41_00443	330214.NIDE1204	8.2e-311	1072.4	Nitrospirae	oadA		2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7	ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K20140	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00307,M00376,M00620	R00209,R00217,R00344,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1		iJN746.PP_5346,iLJ478.TM0128	Bacteria	3J10I@40117,COG0511@1,COG0511@2,COG5016@1,COG5016@2	NA|NA|NA	C	Conserved carboxylase domain
MAG.T21.41_00444	330214.NIDE1203	6.1e-136	490.3	Bacteria			3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120		R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000				Bacteria	COG0596@1,COG0596@2	NA|NA|NA	S	hydrolase activity, acting on ester bonds
MAG.T21.41_00445	330214.NIDE1202	6.9e-103	380.2	Bacteria	tpx		1.11.1.15	ko:K11065					ko00000,ko01000				Bacteria	COG2077@1,COG2077@2	NA|NA|NA	O	thioredoxin peroxidase activity
MAG.T21.41_00446	330214.NIDE1201	2.5e-248	864.4	Nitrospirae	sthA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	3J0IM@40117,COG1249@1,COG1249@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00447	330214.NIDE1200	1.2e-123	449.1	Bacteria	tenA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100		R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000				Bacteria	COG0819@1,COG0819@2	NA|NA|NA	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MAG.T21.41_00451	330214.NIDE2721	4.5e-107	394.0	Bacteria	cusB			ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_00452	330214.NIDE2722	1.7e-307	1061.2	Nitrospirae	secA			ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	3J0E5@40117,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MAG.T21.41_00453	330214.NIDE2723	3.7e-217	760.8	Bacteria	yydH			ko:K01993,ko:K13408,ko:K16922	ko04626,map04626	M00339			ko00000,ko00001,ko00002,ko01002,ko02000,ko02044	8.A.1			Bacteria	COG0845@1,COG0845@2,COG1994@1,COG1994@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_00454	189753.AXAS01000006_gene2277	4.3e-19	102.4	Bacteria													Bacteria	COG3941@1,COG3941@2	NA|NA|NA	O	tape measure
MAG.T21.41_00455	189753.AXAS01000006_gene2278	2.6e-44	184.9	Bradyrhizobiaceae													Bacteria	1QT93@1224,29PSM@1,2V452@28211,30AQU@2,3K55S@41294	NA|NA|NA		
MAG.T21.41_00456	536019.Mesop_3763	2.4e-112	412.9	Alphaproteobacteria													Bacteria	1N1US@1224,2EAGC@1,2UEQF@28211,334JN@2	NA|NA|NA		
MAG.T21.41_00459	189753.AXAS01000006_gene2281	1.1e-16	95.1	Bacteria													Bacteria	COG5164@1,COG5164@2	NA|NA|NA	K	cell wall organization
MAG.T21.41_00461	1131814.JAFO01000001_gene2107	3.6e-09	67.8	Alphaproteobacteria													Bacteria	1PAHP@1224,28UTN@1,2UWVJ@28211,2ZGXT@2	NA|NA|NA		
MAG.T21.41_00462	1114964.L485_16425	7.5e-44	183.7	Sphingomonadales													Bacteria	1N19W@1224,2KDA7@204457,2UD6N@28211,COG0791@1,COG0791@2	NA|NA|NA	M	NLP P60 protein
MAG.T21.41_00465	78245.Xaut_4827	2.1e-177	628.6	Alphaproteobacteria			3.1.21.4	ko:K01155					ko00000,ko01000,ko02048				Bacteria	1MXBM@1224,28HKD@1,2TR3J@28211,2Z7V8@2	NA|NA|NA	S	Type II restriction enzyme
MAG.T21.41_00466	1122962.AULH01000019_gene268	2.8e-41	174.9	Methylocystaceae	yqaA												Bacteria	1RHUV@1224,2U9F7@28211,370BT@31993,COG1238@1,COG1238@2	NA|NA|NA	S	SNARE associated Golgi protein
MAG.T21.41_00467	1120792.JAFV01000001_gene297	4.6e-156	558.1	Methylocystaceae	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01011,ko03036			iSSON_1240.SSON_0092	Bacteria	1MUNY@1224,2TSHQ@28211,36XWS@31993,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin-binding Protein dimerisation domain
MAG.T21.41_00469	1499967.BAYZ01000076_gene830	1.4e-36	160.2	Bacteria													Bacteria	COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAG.T21.41_00471	330214.NIDE4240	0.0	1881.3	Nitrospirae				ko:K02660	ko02020,ko02025,map02020,map02025				ko00000,ko00001,ko02035,ko02044				Bacteria	3J10H@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00472	330214.NIDE4241	2.3e-106	391.7	Bacteria			3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000				Bacteria	COG0637@1,COG0637@2	NA|NA|NA	S	phosphonoacetaldehyde hydrolase activity
MAG.T21.41_00475	395964.KE386496_gene1278	3.1e-20	104.8	Alphaproteobacteria	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02601,ko:K05785					ko00000,ko03000,ko03009,ko03021				Bacteria	1N01W@1224,2U697@28211,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination
MAG.T21.41_00476	69279.BG36_08315	2.2e-83	316.2	Phyllobacteriaceae	wcaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.187,2.7.8.40	ko:K05946,ko:K21303	ko05111,map05111				ko00000,ko00001,ko01000,ko01003,ko01005		GT26		Bacteria	1MV6W@1224,2U148@28211,43KJP@69277,COG2148@1,COG2148@2	NA|NA|NA	M	Bacterial sugar transferase
MAG.T21.41_00477	1120983.KB894574_gene860	3.8e-56	226.1	Rhodobiaceae				ko:K18814					ko00000,ko02000	9.B.67.1			Bacteria	1JQF7@119043,1PR67@1224,2VCTX@28211,COG3307@1,COG3307@2	NA|NA|NA	M	O-Antigen ligase
MAG.T21.41_00478	1120983.KB894574_gene863	1.2e-52	213.4	Alphaproteobacteria	ywqE		3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	1R5E2@1224,2U3T5@28211,COG4464@1,COG4464@2	NA|NA|NA	GM	PFAM PHP domain protein
MAG.T21.41_00479	1120983.KB894574_gene864	4.6e-45	188.3	Rhodobiaceae	gumB			ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Bacteria	1JP5W@119043,1MXYS@1224,2U93S@28211,COG1596@1,COG1596@2	NA|NA|NA	M	Polysaccharide biosynthesis/export protein
MAG.T21.41_00480	330214.NIDE3325	4e-42	178.7	Nitrospirae													Bacteria	3J1EU@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_00481	330214.NIDE3324	3.3e-230	804.3	Nitrospirae				ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2			Bacteria	3J0N2@40117,COG1538@1,COG1538@2	NA|NA|NA	M	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00482	330214.NIDE3323	1.1e-143	516.2	Bacteria				ko:K01993					ko00000				Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_00483	330214.NIDE3322	2.6e-111	408.3	Nitrospirae	hrtA			ko:K02003,ko:K09810,ko:K09814	ko02010,map02010	M00255,M00257,M00258			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125			Bacteria	3J10N@40117,COG1136@1,COG1136@2	NA|NA|NA	V	Evidence 2b Function of strongly homologous gene
MAG.T21.41_00484	330214.NIDE3321	4.8e-178	630.6	Bacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG0577@1,COG0577@2	NA|NA|NA	V	efflux transmembrane transporter activity
MAG.T21.41_00486	330214.NIDE3319	6.9e-308	1062.8	Bacteria	nifA			ko:K02584,ko:K12146,ko:K15836	ko02020,map02020				ko00000,ko00001,ko03000				Bacteria	COG3604@1,COG3604@2	NA|NA|NA	KT	transcription factor binding
MAG.T21.41_00487	330214.NIDE3318	6.5e-196	690.3	Bacteria													Bacteria	COG1293@1,COG1293@2	NA|NA|NA	K	actin binding
MAG.T21.41_00489	1353529.M899_3445	3.4e-25	123.2	Bacteria													Bacteria	2EJ8D@1,33CZJ@2	NA|NA|NA		
MAG.T21.41_00491	330214.NIDE3315	2e-176	625.2	Bacteria													Bacteria	COG3291@1,COG3291@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_00492	330214.NIDE3314	0.0	1105.5	Bacteria													Bacteria	COG0531@1,COG0531@2	NA|NA|NA	E	amino acid
MAG.T21.41_00500	75379.Tint_0304	2.4e-124	452.2	unclassified Burkholderiales				ko:K07496					ko00000				Bacteria	1KN7Z@119065,1MUU0@1224,2VJG9@28216,COG0675@1,COG0675@2	NA|NA|NA	L	Helix-turn-helix domain
MAG.T21.41_00503	75379.Tint_0304	6.4e-117	427.6	unclassified Burkholderiales				ko:K07496					ko00000				Bacteria	1KN7Z@119065,1MUU0@1224,2VJG9@28216,COG0675@1,COG0675@2	NA|NA|NA	L	Helix-turn-helix domain
MAG.T21.41_00505	314278.NB231_12801	3.9e-26	124.0	Gammaproteobacteria				ko:K21498					ko00000,ko02048				Bacteria	1N2TD@1224,1SE1M@1236,COG3093@1,COG3093@2	NA|NA|NA	K	TIGRFAM Addiction module antidote protein, HigA
MAG.T21.41_00506	330214.NIDE0524	8.6e-84	316.6	Bacteria			4.4.1.31	ko:K02632	ko00196,map00196				ko00000,ko00001,ko00194,ko01000				Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00507	330214.NIDE0525	8.8e-145	519.6	Nitrospirae				ko:K07098					ko00000				Bacteria	3J0SB@40117,COG1408@1,COG1408@2	NA|NA|NA	S	Calcineurin-like phosphoesterase
MAG.T21.41_00509	330214.NIDE0527	2.1e-175	621.7	Bacteria	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176					ko00000,ko01000,ko03016				Bacteria	COG0585@1,COG0585@2	NA|NA|NA	J	pseudouridine synthase activity
MAG.T21.41_00510	330214.NIDE0528	4.9e-200	703.7	Bacteria													Bacteria	COG1915@1,COG1915@2	NA|NA|NA	E	PFAM LOR SDH bifunctional enzyme conserved region
MAG.T21.41_00511	330214.NIDE0529	2.1e-127	461.8	Bacteria		GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130		R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007				Bacteria	COG1834@1,COG1834@2	NA|NA|NA	E	dimethylargininase activity
MAG.T21.41_00513	330214.NIDE0531	2.3e-150	538.5	Nitrospirae	gpsA		1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110		R00842,R00844	RC00029	ko00000,ko00001,ko01000				Bacteria	3J0GP@40117,COG0240@1,COG0240@2	NA|NA|NA	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
MAG.T21.41_00514	330214.NIDE0532	5.9e-122	443.7	Bacteria	cpmA			ko:K06898					ko00000				Bacteria	COG1691@1,COG1691@2	NA|NA|NA	C	(AIR) carboxylase
MAG.T21.41_00516	330214.NIDE0534	8.4e-189	666.4	Bacteria	larC		4.99.1.12	ko:K09121					ko00000,ko01000				Bacteria	COG1641@1,COG1641@2	NA|NA|NA	H	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MAG.T21.41_00517	330214.NIDE0535	5.4e-163	580.5	Nitrospirae				ko:K07301					ko00000,ko02000	2.A.19.5			Bacteria	3J0V1@40117,COG0530@1,COG0530@2	NA|NA|NA	P	Sodium/calcium exchanger protein
MAG.T21.41_00518	330214.NIDE0536	6.2e-172	610.1	Nitrospirae	pdxA		1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0GF@40117,COG1995@1,COG1995@2	NA|NA|NA	C	Pyridoxal phosphate biosynthetic protein PdxA
MAG.T21.41_00520	330214.NIDE0538	1.9e-120	438.7	Nitrospirae	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182,2.1.1.184	ko:K00561,ko:K02528			R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009				Bacteria	3J0R6@40117,COG0030@1,COG0030@2	NA|NA|NA	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MAG.T21.41_00522	360910.BAV0422	1e-89	336.7	Alcaligenaceae													Bacteria	1NBHR@1224,28HPK@1,2VU8A@28216,2Z7XJ@2,3T6RG@506	NA|NA|NA	S	Bacteriophage head to tail connecting protein
MAG.T21.41_00523	50948.Q76ZH7_9CAUD	3.8e-08	64.7	Myoviridae													Viruses	4QH74@10239,4QJBB@10662,4QQMA@28883,4R0E6@35237	NA|NA|NA		
MAG.T21.41_00524	107636.JQNK01000002_gene127	1.6e-12	78.6	Alphaproteobacteria													Bacteria	1NHDG@1224,2EK5N@1,2UJBG@28211,33DW2@2	NA|NA|NA		
MAG.T21.41_00525	371731.Rsw2DRAFT_0416	1.4e-27	131.3	Bacteria			3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100		R06200,R11307,R11308		ko00000,ko00001,ko01000		GH5,GH9		Bacteria	COG4733@1,COG4733@2	NA|NA|NA	S	cellulase activity
MAG.T21.41_00527	194699.Q775C5_BPBPP	2e-34	151.8	Podoviridae													Viruses	4QHDG@10239,4QNP1@10744,4QRSG@28883,4QYUZ@35237	NA|NA|NA		
MAG.T21.41_00528	557598.LHK_01541	7.4e-38	164.1	Betaproteobacteria													Bacteria	1RKX8@1224,2AXQF@1,2W377@28216,31PR8@2	NA|NA|NA		
MAG.T21.41_00529	1094489.BAnh1_09900	3.1e-107	395.2	Alphaproteobacteria													Bacteria	1PJBP@1224,28HXV@1,2U8DN@28211,2Z83C@2	NA|NA|NA		
MAG.T21.41_00530	343516.Q287A7_9CAUD	2.5e-13	82.0	Podoviridae													Viruses	4QGFZ@10239,4QNJN@10744,4QU5D@28883,4QVJ7@35237	NA|NA|NA		
MAG.T21.41_00532	194699.Q775D0_BPBPP	2.3e-58	232.3	Podoviridae		GO:0005575,GO:0019012											Viruses	4QBMX@10239,4QNC1@10744,4QQGF@28883,4QV9I@35237	NA|NA|NA	S	Pfam:Tube
MAG.T21.41_00533	330214.NIDE1304	0.0	1685.6	Nitrospirae	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	3J0BT@40117,COG0086@1,COG0086@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T21.41_00534	330214.NIDE1306	5.4e-62	243.4	Nitrospirae	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02950	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0IU@40117,COG0048@1,COG0048@2	NA|NA|NA	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MAG.T21.41_00535	330214.NIDE1307	1.9e-83	315.1	Nitrospirae	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02992	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0HK@40117,COG0049@1,COG0049@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MAG.T21.41_00537	401526.TcarDRAFT_1099	2.3e-21	109.0	Firmicutes													Bacteria	1VZAC@1239,2ABAI@1,310R4@2	NA|NA|NA		
MAG.T21.41_00538	136993.KB900626_gene2775	1.5e-37	164.5	Alphaproteobacteria													Bacteria	1N7TC@1224,2CZBU@1,2UIQ6@28211,32T60@2	NA|NA|NA		
MAG.T21.41_00539	330214.NIDE0425	4.5e-118	430.6	Nitrospirae	plsC		2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J16H@40117,COG0204@1,COG0204@2	NA|NA|NA	I	Phosphate acyltransferases
MAG.T21.41_00540	330214.NIDE0424	3.2e-108	397.9	Nitrospirae	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1	ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799	ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010	M00022,M00052,M00096,M00119,M00125,M00178	R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210	RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011			iPC815.YPO1391,iSDY_1059.SDY_2348	Bacteria	3J0MY@40117,COG0283@1,COG0283@2	NA|NA|NA	F	Belongs to the cytidylate kinase family. Type 1 subfamily
MAG.T21.41_00541	330214.NIDE0423	1.4e-216	758.8	Nitrospirae	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0BZ@40117,COG0128@1,COG0128@2	NA|NA|NA	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MAG.T21.41_00542	330214.NIDE0422	1.8e-151	542.0	Nitrospirae	aroA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0SQ@40117,COG0287@1,COG0287@2	NA|NA|NA	C	Prephenate dehydrogenase
MAG.T21.41_00543	330214.NIDE0421	1.6e-185	655.2	Nitrospirae	aroF		2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0A5@40117,COG2876@1,COG2876@2	NA|NA|NA	E	NeuB family
MAG.T21.41_00544	330214.NIDE0420	7.1e-187	659.8	Nitrospirae	hisC		2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0XY@40117,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MAG.T21.41_00546	330214.NIDE0419	5.1e-193	680.2	Nitrospirae	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	1.3.1.12,2.3.1.79,4.2.1.51,4.2.1.91,5.4.99.5	ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715,R01728	RC00125,RC00360,RC03116	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2667	Bacteria	3J0A9@40117,COG0077@1,COG0077@2,COG1605@1,COG1605@2	NA|NA|NA	E	Chorismate mutase type II
MAG.T21.41_00547	330214.NIDE0418	7.6e-178	629.8	Nitrospirae	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0AU@40117,COG2255@1,COG2255@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MAG.T21.41_00549	330214.NIDE0416	3.5e-90	337.8	Nitrospirae	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0VA@40117,COG0632@1,COG0632@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MAG.T21.41_00550	330214.NIDE0415	9.8e-127	459.5	Nitrospirae	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	3J0DM@40117,COG0217@1,COG0217@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_00551	330214.NIDE0414	2e-91	342.4	Bacteria													Bacteria	COG4244@1,COG4244@2	NA|NA|NA	E	Membrane
MAG.T21.41_00552	330214.NIDE0413	1.5e-130	472.2	Bacteria	bchB												Bacteria	2DQ3Q@1,334KX@2	NA|NA|NA	S	Proto-chlorophyllide reductase 57 kd subunit
MAG.T21.41_00553	330214.NIDE0412	1.5e-164	585.5	Bacteria				ko:K03593					ko00000,ko03029,ko03036				Bacteria	COG0489@1,COG0489@2	NA|NA|NA	D	protein tyrosine kinase activity
MAG.T21.41_00554	330214.NIDE0411	0.0	1159.8	Bacteria	cysC		2.7.1.25,2.7.7.4	ko:K00860,ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0529@1,COG0529@2,COG2895@1,COG2895@2	NA|NA|NA	P	sulfate adenylyltransferase (ATP) activity
MAG.T21.41_00555	330214.NIDE0410	5.5e-152	543.5	Bacteria	cysD		1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0175@1,COG0175@2	NA|NA|NA	EH	sulfate reduction
MAG.T21.41_00556	330214.NIDE0409	1.6e-170	605.5	Nitrospirae													Bacteria	3J17P@40117,COG0547@1,COG0547@2	NA|NA|NA	E	Glycosyl transferase family, a/b domain
MAG.T21.41_00557	330214.NIDE0408	1.3e-120	439.1	Bacteria	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0175@1,COG0175@2	NA|NA|NA	EH	sulfate reduction
MAG.T21.41_00558	330214.NIDE0407	0.0	1496.9	Nitrospirae	cysI		1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1	ko:K00362,ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00530,M00531	R00787,R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000				Bacteria	3J11D@40117,COG0155@1,COG0155@2,COG0425@1,COG0425@2	NA|NA|NA	C	Nitrite and sulphite reductase 4Fe-4S domain
MAG.T21.41_00559	330214.NIDE0406	5.8e-66	256.9	Bacteria	iscR		2.8.1.7	ko:K04487,ko:K13643	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029				Bacteria	COG1959@1,COG1959@2	NA|NA|NA	K	2 iron, 2 sulfur cluster binding
MAG.T21.41_00560	330214.NIDE0405	3.8e-78	297.7	Bacteria	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03557,ko:K07712	ko02020,ko05111,map02020,map05111	M00497			ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400				Bacteria	COG2901@1,COG2901@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_00561	330214.NIDE0404	1.3e-36	158.7	Nitrospirae	hupB			ko:K03530,ko:K04764					ko00000,ko03032,ko03036,ko03400				Bacteria	3J0V6@40117,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MAG.T21.41_00563	330214.NIDE0403	0.0	1226.8	Nitrospirae	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	3J0F4@40117,COG0441@1,COG0441@2	NA|NA|NA	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAG.T21.41_00564	330214.NIDE0402	2.7e-49	201.1	Nitrospirae	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Bacteria	3J0T0@40117,COG0290@1,COG0290@2	NA|NA|NA	J	Translation initiation factor IF-3, C-terminal domain
MAG.T21.41_00565	330214.NIDE0401	6.9e-24	115.9	Nitrospirae	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02916	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J1F4@40117,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
MAG.T21.41_00566	330214.NIDE0400	2.6e-56	224.6	Nitrospirae	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02887	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0SF@40117,COG0292@1,COG0292@2	NA|NA|NA	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MAG.T21.41_00567	330214.NIDE0399	1.4e-298	1031.6	Nitrospirae	pheT		6.1.1.20	ko:K01889,ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	3J0U7@40117,COG0072@1,COG0072@2	NA|NA|NA	J	B3/4 domain
MAG.T21.41_00568	330214.NIDE0398	5.4e-268	929.9	Nitrospirae	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	3J0SW@40117,COG0016@1,COG0016@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type
MAG.T21.41_00569	330214.NIDE0397	1.5e-108	399.1	Nitrospirae	rpe		5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0IZ@40117,COG0036@1,COG0036@2	NA|NA|NA	G	Ribulose-phosphate 3 epimerase family
MAG.T21.41_00570	330214.NIDE0396	3.3e-205	721.1	Nitrospirae	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500					ko00000,ko01000,ko03009				Bacteria	3J136@40117,COG0144@1,COG0144@2,COG0781@1,COG0781@2	NA|NA|NA	J	16S rRNA methyltransferase RsmB/F
MAG.T21.41_00571	330214.NIDE0395	5.3e-154	550.4	Nitrospirae	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000				Bacteria	3J0GW@40117,COG0223@1,COG0223@2	NA|NA|NA	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAG.T21.41_00572	1219035.NT2_08_00530	5.2e-111	407.5	Sphingomonadales				ko:K07506					ko00000,ko03000				Bacteria	1RJPK@1224,2K49J@204457,2TV79@28211,COG2207@1,COG2207@2	NA|NA|NA	K	helix_turn_helix, arabinose operon control protein
MAG.T21.41_00574	710686.Mycsm_06464	8.5e-10	70.5	Actinobacteria													Bacteria	2BA2X@1,2H850@201174,323GP@2	NA|NA|NA		
MAG.T21.41_00575	330214.NIDE0912	1.3e-36	158.7	Bacteria				ko:K07483,ko:K07497					ko00000				Bacteria	COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
MAG.T21.41_00576	94624.Bpet4636	5.6e-72	277.7	Betaproteobacteria				ko:K07497					ko00000				Bacteria	1MVN5@1224,2VII1@28216,COG2801@1,COG2801@2	NA|NA|NA	L	similarity to GP 17427840
MAG.T21.41_00577	1121948.AUAC01000003_gene2873	1.8e-14	87.4	Hyphomonadaceae													Bacteria	1N06S@1224,2TQVV@28211,43YR0@69657,COG0457@1,COG0457@2	NA|NA|NA	S	MTH538 TIR-like domain (DUF1863)
MAG.T21.41_00578	1353537.TP2_15765	2.3e-174	618.2	Alphaproteobacteria													Bacteria	1R78W@1224,28MZ8@1,2U4VB@28211,2ZB62@2	NA|NA|NA		
MAG.T21.41_00579	330214.NIDE0370	3.2e-278	963.8	Nitrospirae	atpA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		iSB619.SA_RS10975	Bacteria	3J0CZ@40117,COG0056@1,COG0056@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MAG.T21.41_00580	330214.NIDE0369	1.4e-79	302.4	Nitrospirae	atpH			ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	3J1BY@40117,COG0712@1,COG0712@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T21.41_00581	330214.NIDE0368	1.7e-172	612.1	Nitrospirae	mnmA		2.8.1.13	ko:K00566	ko04122,map04122		R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016				Bacteria	3J0KT@40117,COG0482@1,COG0482@2	NA|NA|NA	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MAG.T21.41_00582	330214.NIDE0367	4.5e-66	257.3	Bacteria													Bacteria	COG1664@1,COG1664@2	NA|NA|NA	M	Polymer-forming cytoskeletal
MAG.T21.41_00583	330214.NIDE0366	1.5e-75	288.9	Nitrospirae													Bacteria	3J1F5@40117,COG1664@1,COG1664@2	NA|NA|NA	M	Polymer-forming cytoskeletal
MAG.T21.41_00584	330214.NIDE0365	1.7e-127	462.2	Nitrospirae	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944		ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	3J0K9@40117,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
MAG.T21.41_00585	330214.NIDE0364	6.6e-126	456.8	Nitrospirae	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	3J0H4@40117,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T21.41_00586	639283.Snov_2616	1.6e-20	105.9	Xanthobacteraceae				ko:K03446		M00701			ko00000,ko00002,ko02000	2.A.1.3			Bacteria	1RGPN@1224,2TQKW@28211,3EZ13@335928,COG0477@1,COG0477@2	NA|NA|NA	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily
MAG.T21.41_00587	709797.CSIRO_3190	3.4e-45	187.6	Bradyrhizobiaceae	nrdJ		1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	1MUJ8@1224,2TS2I@28211,3JSVM@41294,COG0209@1,COG0209@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T21.41_00588	648885.KB316282_gene252	2.8e-42	177.9	Methylobacteriaceae				ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6			Bacteria	1JTB1@119045,1QTYW@1224,2TWPT@28211,COG3258@1,COG3258@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T21.41_00589	330214.NIDE1147	7.6e-74	283.9	Bacteria													Bacteria	292MF@1,2ZQ5C@2	NA|NA|NA	S	Protein of unknown function (DUF3047)
MAG.T21.41_00590	330214.NIDE1146	8.7e-242	842.8	Nitrospirae	merA												Bacteria	3J0IM@40117,COG1249@1,COG1249@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00591	330214.NIDE1145	1.3e-73	283.1	Bacteria	merA												Bacteria	COG0398@1,COG0398@2	NA|NA|NA	M	Pfam SNARE associated Golgi protein
MAG.T21.41_00592	314230.DSM3645_07550	1.8e-42	179.5	Planctomycetes	MA20_14875	GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019216,GO:0019219,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0042803,GO:0045828,GO:0045834,GO:0045893,GO:0045935,GO:0046889,GO:0046890,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071214,GO:0071478,GO:0071482,GO:0080090,GO:0097159,GO:0104004,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1904143,GO:2000112,GO:2001141		ko:K01420,ko:K10914,ko:K22490	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	2IZG1@203682,COG0664@1,COG0664@2	NA|NA|NA	K	- catabolite gene activator and regulatory subunit of cAMP-dependent protein
MAG.T21.41_00593	330214.NIDE4185	4.4e-89	334.7	Bacteria	vacJ			ko:K04754					ko00000				Bacteria	COG2853@1,COG2853@2	NA|NA|NA	M	Lipoprotein
MAG.T21.41_00595	443152.MDG893_17567	1.1e-27	130.6	Gammaproteobacteria													Bacteria	1RDZ2@1224,1RYPP@1236,COG0398@1,COG0398@2	NA|NA|NA	S	TVP38 TMEM64 family inner membrane protein ydjZ
MAG.T21.41_00596	671143.DAMO_2648	5.7e-17	94.7	Bacteria				ko:K03286,ko:K12976,ko:K16079					ko00000,ko01000,ko01005,ko02000	1.B.4.2.1,1.B.6			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_00597	1210884.HG799465_gene12253	3.4e-20	105.1	Planctomycetes													Bacteria	2J1JD@203682,COG2128@1,COG2128@2	NA|NA|NA	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAG.T21.41_00598	1049564.TevJSym_ar00440	1.6e-82	313.2	Gammaproteobacteria													Bacteria	1N82C@1224,1RQQI@1236,COG2128@1,COG2128@2	NA|NA|NA	S	Protein of unknown function (DUF3179)
MAG.T21.41_00602	330214.NIDE3686	3.1e-70	271.2	Bacteria	glbN			ko:K06886					ko00000				Bacteria	COG2346@1,COG2346@2	NA|NA|NA	O	COG2346, Truncated hemoglobins
MAG.T21.41_00603	330214.NIDE3685	1.4e-91	342.4	Bacteria	sigK	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090		ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_00604	330214.NIDE3684	1.4e-80	305.8	Bacteria				ko:K07167					ko00000				Bacteria	COG3806@1,COG3806@2	NA|NA|NA	T	Anti-sigma factor
MAG.T21.41_00605	330214.NIDE3683	1.1e-43	182.6	Bacteria													Bacteria	2CNK3@1,32SH9@2	NA|NA|NA	S	Protein of Unknown function (DUF2784)
MAG.T21.41_00606	234267.Acid_7898	1.5e-16	92.0	Acidobacteria													Bacteria	3Y4X5@57723,COG5483@1,COG5483@2	NA|NA|NA	S	Protein of unknown function, DUF488
MAG.T21.41_00607	330214.NIDE3682	7.7e-40	169.9	Bacteria				ko:K07343					ko00000				Bacteria	COG3070@1,COG3070@2	NA|NA|NA	K	positive regulation of type IV pilus biogenesis
MAG.T21.41_00610	330214.NIDE3680	3.5e-144	517.7	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00611	661478.OP10G_4489	4.5e-19	101.3	Bacteria													Bacteria	2A52F@1,30TQU@2	NA|NA|NA		
MAG.T21.41_00612	330214.NIDE3677	4.8e-68	264.2	Bacteria													Bacteria	297W1@1,2ZV2M@2	NA|NA|NA	S	Domain of unknown function (DUF4396)
MAG.T21.41_00614	330214.NIDE2815	5.2e-187	660.6	Bacteria													Bacteria	COG3664@1,COG3664@2	NA|NA|NA	G	PFAM glycoside hydrolase family 39
MAG.T21.41_00615	330214.NIDE2816	6.2e-168	597.0	Nitrospirae	phcR			ko:K19622	ko02020,map02020				ko00000,ko00001,ko02022				Bacteria	3J0NC@40117,COG1639@1,COG1639@2,COG2204@1,COG2204@2	NA|NA|NA	T	HDOD domain
MAG.T21.41_00616	330214.NIDE2817	2.9e-61	241.5	Nitrospirae	lspG			ko:K02456	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	3J14E@40117,COG4968@1,COG4968@2	NA|NA|NA	U	Type II secretion system (T2SS), protein G
MAG.T21.41_00617	330214.NIDE2818	6.1e-252	876.7	Bacteria													Bacteria	2F0JI@1,33TN8@2	NA|NA|NA		
MAG.T21.41_00618	330214.NIDE2819	4.7e-217	760.4	Nitrospirae	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0293,iYO844.BSU13130	Bacteria	3J0ET@40117,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAG.T21.41_00619	330214.NIDE2820	2.5e-88	331.6	Bacteria	tklG			ko:K10927	ko05111,map05111				ko00000,ko00001,ko02044				Bacteria	COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
MAG.T21.41_00620	330214.NIDE4159	6.6e-67	260.0	Bacteria													Bacteria	2E4SV@1,32ZM7@2	NA|NA|NA		
MAG.T21.41_00621	330214.NIDE4158	0.0	1501.1	Nitrospirae	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7,3.1.26.4	ko:K02335,ko:K03469	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	3J0DP@40117,COG0258@1,COG0258@2,COG0749@1,COG0749@2	NA|NA|NA	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAG.T21.41_00622	330214.NIDE4157	2.6e-59	234.6	Bacteria													Bacteria	COG3824@1,COG3824@2	NA|NA|NA	S	Zincin-like metallopeptidase
MAG.T21.41_00624	330214.NIDE4155	3.7e-219	767.3	Bacteria													Bacteria	293H1@1,2ZQZ6@2	NA|NA|NA		
MAG.T21.41_00626	330214.NIDE3510	9e-40	171.4	Bacteria													Bacteria	2DT3N@1,33IIR@2	NA|NA|NA		
MAG.T21.41_00627	330214.NIDE4152	5.7e-165	587.0	Bacteria													Bacteria	COG1524@1,COG1524@2	NA|NA|NA	S	mannose-ethanolamine phosphotransferase activity
MAG.T21.41_00629	330214.NIDE4150	5e-113	414.8	Nitrospirae													Bacteria	3J1E2@40117,COG1413@1,COG1413@2	NA|NA|NA	C	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00630	330214.NIDE4149	1.5e-160	572.4	Nitrospirae													Bacteria	3J1E2@40117,COG1413@1,COG1413@2	NA|NA|NA	C	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00631	330214.NIDE4148	2e-165	588.6	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00632	330214.NIDE4147	3.1e-19	102.4	Nitrospirae													Bacteria	3J1E2@40117,COG1413@1,COG1413@2	NA|NA|NA	C	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00633	330214.NIDE4146	3.8e-88	331.3	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00634	330214.NIDE4145	5.9e-244	849.7	Nitrospirae	rkpK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0EJ@40117,COG1004@1,COG1004@2	NA|NA|NA	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T21.41_00635	330214.NIDE4144	9e-58	229.6	Bacteria	opuCA		2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12			Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_00636	330214.NIDE4143	1.2e-267	928.7	Bacteria	speE		2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0421@1,COG0421@2	NA|NA|NA	E	spermidine synthase activity
MAG.T21.41_00639	330214.NIDE4140	2.7e-63	247.7	Nitrospirae	yfhL			ko:K03522,ko:K05337					ko00000,ko04147				Bacteria	3J1BF@40117,COG1145@1,COG1145@2	NA|NA|NA	C	4Fe-4S dicluster domain
MAG.T21.41_00640	330214.NIDE4139	4e-76	290.8	Bacteria				ko:K09005					ko00000				Bacteria	COG1430@1,COG1430@2	NA|NA|NA	S	Uncharacterized ACR, COG1430
MAG.T21.41_00641	330214.NIDE4138	1.1e-52	212.2	Nitrospirae			1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	3J1E7@40117,COG2146@1,COG2146@2	NA|NA|NA	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00643	330214.NIDE4136	1.1e-121	443.0	Bacteria	dat	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100		R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007				Bacteria	COG0115@1,COG0115@2	NA|NA|NA	E	branched-chain-amino-acid transaminase activity
MAG.T21.41_00644	330214.NIDE4135	2.9e-69	268.1	Nitrospirae	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K09748					ko00000,ko03009				Bacteria	3J0UD@40117,COG0779@1,COG0779@2	NA|NA|NA	J	Required for maturation of 30S ribosomal subunits
MAG.T21.41_00645	330214.NIDE4134	5e-199	700.3	Nitrospirae	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Bacteria	3J0DF@40117,COG0195@1,COG0195@2	NA|NA|NA	K	Participates in both transcription termination and antitermination
MAG.T21.41_00646	330214.NIDE4133	0.0	1348.2	Nitrospirae	infB			ko:K02519					ko00000,ko03012,ko03029				Bacteria	3J0CC@40117,COG0532@1,COG0532@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MAG.T21.41_00647	330214.NIDE4132	6.4e-39	166.4	Bacteria	ylxP			ko:K09764					ko00000				Bacteria	COG1550@1,COG1550@2	NA|NA|NA	H	Protein conserved in bacteria
MAG.T21.41_00648	330214.NIDE4131	5.9e-46	190.3	Nitrospirae	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K02834					ko00000,ko03009				Bacteria	3J0VV@40117,COG0858@1,COG0858@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MAG.T21.41_00649	330214.NIDE4130	2.2e-137	495.4	Nitrospirae	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K03483					ko00000,ko01000,ko03000,ko03016			iSB619.SA_RS06305	Bacteria	3J0KH@40117,COG0130@1,COG0130@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MAG.T21.41_00650	330214.NIDE4129	1e-38	165.6	Nitrospirae	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02956	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0RA@40117,COG0184@1,COG0184@2	NA|NA|NA	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MAG.T21.41_00651	330214.NIDE4127	0.0	1296.2	Nitrospirae	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Bacteria	3J0DX@40117,COG1185@1,COG1185@2	NA|NA|NA	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MAG.T21.41_00652	330214.NIDE4126	2.1e-219	768.1	Nitrospirae	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	3J0GS@40117,COG0612@1,COG0612@2	NA|NA|NA	S	Insulinase (Peptidase family M16)
MAG.T21.41_00655	330214.NIDE4122	0.0	1436.0	Nitrospirae	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391		ko:K03555	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	3J0CE@40117,COG0249@1,COG0249@2	NA|NA|NA	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MAG.T21.41_00657	330214.NIDE4120	1.5e-67	262.7	Nitrospirae	yjeE		2.7.1.221	ko:K06925,ko:K07102	ko00520,ko01100,map00520,map01100		R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03016				Bacteria	3J1AZ@40117,COG0802@1,COG0802@2	NA|NA|NA	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE
MAG.T21.41_00658	330214.NIDE4119	9.4e-244	849.4	Nitrospirae	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759					ko00000,ko01000				Bacteria	3J0J1@40117,COG0062@1,COG0062@2,COG0063@1,COG0063@2	NA|NA|NA	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MAG.T21.41_00659	330214.NIDE4117	2.4e-122	444.9	Nitrospirae	pdxJ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000			iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390	Bacteria	3J0KZ@40117,COG0854@1,COG0854@2	NA|NA|NA	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MAG.T21.41_00660	330214.NIDE4115	2.3e-231	807.7	Nitrospirae	yfdZ	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007			iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Bacteria	3J0ED@40117,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase class I and II
MAG.T21.41_00661	330214.NIDE4114	4.2e-226	790.4	Nitrospirae	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.2.1.6	ko:K00003,ko:K01653	ko00260,ko00270,ko00290,ko00300,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00270,map00290,map00300,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00017,M00018,M00019,M00570	R00006,R00014,R00226,R01773,R01775,R03050,R04672,R04673,R08648	RC00027,RC00087,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1294,iSB619.SA_RS06610	Bacteria	3J0G1@40117,COG0440@1,COG0440@2,COG0460@1,COG0460@2	NA|NA|NA	E	Homoserine dehydrogenase
MAG.T21.41_00662	330214.NIDE4113	4.5e-186	657.1	Nitrospirae	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250	Bacteria	3J0FI@40117,COG0498@1,COG0498@2	NA|NA|NA	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAG.T21.41_00663	330214.NIDE4112	4.8e-203	713.8	Nitrospirae	apgM		5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0YA@40117,COG3635@1,COG3635@2	NA|NA|NA	G	Metalloenzyme superfamily
MAG.T21.41_00664	330214.NIDE4111	1.4e-207	728.8	Nitrospirae	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0AZ@40117,COG0527@1,COG0527@2	NA|NA|NA	E	ACT domain
MAG.T21.41_00665	330214.NIDE4110	1.4e-287	995.0	Nitrospirae	leuA2		2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0DC@40117,COG0119@1,COG0119@2	NA|NA|NA	E	Belongs to the alpha-IPM synthase homocitrate synthase family
MAG.T21.41_00666	330214.NIDE4109	3.8e-42	177.2	Nitrospirae	himA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K04764,ko:K05788					ko00000,ko03032,ko03036,ko03400				Bacteria	3J1CY@40117,COG0776@1,COG0776@2	NA|NA|NA	L	bacterial (prokaryotic) histone like domain
MAG.T21.41_00667	330214.NIDE4108	7.2e-56	223.0	Nitrospirae	ycgE			ko:K19591,ko:K22491		M00769			ko00000,ko00002,ko01504,ko03000				Bacteria	3J0VF@40117,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T21.41_00669	330214.NIDE4107	9e-126	456.4	Nitrospirae	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iSFxv_1172.SFxv_3035	Bacteria	3J0IG@40117,COG0496@1,COG0496@2	NA|NA|NA	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MAG.T21.41_00670	330214.NIDE4106	5.8e-112	410.2	Bacteria	dedA												Bacteria	COG0586@1,COG0586@2	NA|NA|NA	S	FtsZ-dependent cytokinesis
MAG.T21.41_00671	330214.NIDE4105	1.4e-241	842.0	Nitrospirae	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECUMN_1333.ECUMN_0566,iJN746.PP_2905	Bacteria	3J0CM@40117,COG0215@1,COG0215@2	NA|NA|NA	J	DALR_2
MAG.T21.41_00672	330214.NIDE4104	9.2e-112	409.8	Nitrospirae	rlmB		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	3J0RH@40117,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T21.41_00673	330214.NIDE4103	2.5e-35	154.5	Bacteria				ko:K03413	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00674	330214.NIDE4102	2.1e-116	425.2	Nitrospirae	pilD		3.4.23.43	ko:K02278,ko:K02654		M00331			ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2			Bacteria	3J0SK@40117,COG1989@1,COG1989@2	NA|NA|NA	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MAG.T21.41_00675	330214.NIDE4101	1.8e-48	198.7	Bacteria	VP0657			ko:K02457,ko:K02672,ko:K08084,ko:K08085	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	COG4970@1,COG4970@2	NA|NA|NA	NU	protein transport across the cell outer membrane
MAG.T21.41_00676	330214.NIDE4100	2.8e-64	251.5	Bacteria	comGF			ko:K02246,ko:K02248		M00429			ko00000,ko00002,ko02044				Bacteria	COG4940@1,COG4940@2	NA|NA|NA	U	Putative Competence protein ComGF
MAG.T21.41_00677	330214.NIDE4099	1.3e-78	299.7	Bacteria				ko:K02672					ko00000,ko02035,ko02044				Bacteria	COG4966@1,COG4966@2	NA|NA|NA	NU	pilus assembly protein PilW
MAG.T21.41_00678	330214.NIDE4098	1.9e-214	751.9	Bacteria				ko:K07140					ko00000				Bacteria	COG3217@1,COG3217@2,COG4726@1,COG4726@2	NA|NA|NA	NU	Pilus assembly protein PilX
MAG.T21.41_00682	981327.F925_00156	7.6e-43	181.0	Moraxellaceae				ko:K03496					ko00000,ko03036,ko04812				Bacteria	1NAJP@1224,1S4V1@1236,3NMK3@468,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T21.41_00683	555079.Toce_2277	6.8e-31	141.7	Thermoanaerobacterales	noc			ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	1TP0I@1239,2488X@186801,42F6H@68295,COG1475@1,COG1475@2	NA|NA|NA	K	Belongs to the ParB family
MAG.T21.41_00684	926566.Terro_3115	5.3e-09	69.3	Bacteria	repA												Bacteria	COG5534@1,COG5534@2	NA|NA|NA	L	Replication initiator protein
MAG.T21.41_00685	187272.Mlg_2300	1.9e-26	124.8	Proteobacteria				ko:K15773					ko00000,ko02048,ko03000				Bacteria	1QWRC@1224,COG1476@1,COG1476@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_00686	883078.HMPREF9695_04745	1.1e-170	606.3	Bradyrhizobiaceae	hipA		2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Bacteria	1MVAB@1224,2U1TN@28211,3JWF0@41294,COG3550@1,COG3550@2	NA|NA|NA	S	HipA N-terminal domain
MAG.T21.41_00687	1499967.BAYZ01000003_gene5836	1e-11	77.4	Bacteria				ko:K06985	ko04112,map04112				ko00000,ko00001				Bacteria	COG0457@1,COG0457@2,COG3577@1,COG3577@2	NA|NA|NA	S	aspartic-type endopeptidase activity
MAG.T21.41_00688	330214.NIDE2901	6.7e-18	97.8	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00701	330214.NIDE2813	2.6e-44	184.9	Bacteria	yuxK												Bacteria	COG3011@1,COG3011@2	NA|NA|NA	CH	Protein conserved in bacteria
MAG.T21.41_00702	330214.NIDE2788	8.3e-85	319.7	Bacteria													Bacteria	2EBKA@1,335KQ@2	NA|NA|NA		
MAG.T21.41_00703	1297742.A176_05408	4.4e-55	221.5	Myxococcales													Bacteria	1MURA@1224,2X6F0@28221,2YXND@29,42RGG@68525,COG0491@1,COG0491@2	NA|NA|NA	P	COG0491 Zn-dependent hydrolases, including glyoxylases
MAG.T21.41_00704	330214.NIDE3480	3.8e-63	247.7	Nitrospirae	MA20_44930		2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000				Bacteria	3J19H@40117,COG3865@1,COG3865@2	NA|NA|NA	H	3-demethylubiquinone-9 3-methyltransferase
MAG.T21.41_00706	330214.NIDE1069	5.6e-35	153.3	Bacteria													Bacteria	2DJBU@1,32UCQ@2	NA|NA|NA		
MAG.T21.41_00707	1336243.JAEA01000003_gene2422	2.4e-32	145.2	Methylobacteriaceae	nudF		3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000,ko03400				Bacteria	1JYK8@119045,1N1KH@1224,2UA1K@28211,COG1051@1,COG1051@2	NA|NA|NA	F	NUDIX domain
MAG.T21.41_00709	330214.NIDE2799	3.6e-106	391.0	Bacteria	yrdA			ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	COG0663@1,COG0663@2	NA|NA|NA	G	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MAG.T21.41_00710	240015.ACP_1401	6.2e-131	474.2	Acidobacteriia	ilvA		4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0356	Bacteria	2JHRQ@204432,3Y2RI@57723,COG1171@1,COG1171@2	NA|NA|NA	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit
MAG.T21.41_00713	330214.NIDE3050	2.3e-69	269.6	Bacteria			3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4251@1,COG4251@2	NA|NA|NA	T	Pas domain
MAG.T21.41_00714	330214.NIDE2793	2.8e-23	114.4	Bacteria			4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220		R03470	RC00938	ko00000,ko00001,ko01000				Bacteria	COG0599@1,COG0599@2	NA|NA|NA	S	peroxiredoxin activity
MAG.T21.41_00715	330214.NIDE2794	7e-110	403.7	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00716	330214.NIDE2795	1.7e-134	485.7	Bacteria													Bacteria	COG4977@1,COG4977@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_00718	330214.NIDE2814	2.6e-45	188.3	Nitrospirae													Bacteria	3J1F1@40117,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T21.41_00719	556263.FSEG_00086	2.9e-09	69.3	Fusobacteria													Bacteria	2C4D9@1,33C3U@2,37C2I@32066	NA|NA|NA	S	Protein of unknown function (DUF1353)
MAG.T21.41_00723	330214.NIDE2242	2.9e-163	581.3	Bacteria													Bacteria	COG0535@1,COG0535@2	NA|NA|NA	I	radical SAM domain protein
MAG.T21.41_00724	330214.NIDE2241	1.7e-162	578.9	Bacteria				ko:K03112					ko00000				Bacteria	COG3266@1,COG3266@2	NA|NA|NA	GM	domain, Protein
MAG.T21.41_00725	1089545.KB913037_gene9162	2.5e-09	71.2	Actinobacteria			1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6			Bacteria	2I4WG@201174,COG3064@1,COG3064@2	NA|NA|NA	M	Domain of unknown function (DUF4157)
MAG.T21.41_00727	330214.NIDE2238	1.2e-20	104.8	Bacteria													Bacteria	COG4447@1,COG4447@2	NA|NA|NA	S	cellulose binding
MAG.T21.41_00729	158822.LH89_15090	5.6e-86	325.5	Gammaproteobacteria	prhA			ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1NCN6@1224,1S1Q0@1236,COG4773@1,COG4773@2	NA|NA|NA	P	TonB-dependent siderophore receptor
MAG.T21.41_00730	330214.NIDE3910	1.1e-95	356.7	Nitrospirae		GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704	4.2.3.118	ko:K16218					ko00000,ko01000				Bacteria	3J1CW@40117,COG3170@1,COG3170@2	NA|NA|NA	NU	Protein of unknown function (DUF1207)
MAG.T21.41_00731	237368.SCABRO_02469	1.3e-143	516.2	Planctomycetes	ybhR			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2IYZA@203682,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 type transporter
MAG.T21.41_00732	247490.KSU1_D0847	1.6e-133	482.6	Planctomycetes	ybhS			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2J1QC@203682,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T21.41_00733	237368.SCABRO_02472	1.7e-49	202.2	Planctomycetes	ybhF-C			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2J4Y7@203682,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T21.41_00734	330214.NIDE2377	4.2e-187	660.6	Nitrospirae	wecB		3.2.1.184,5.1.3.14	ko:K01791,ko:K18429	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R10187	RC00005,RC00288,RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J148@40117,COG0381@1,COG0381@2	NA|NA|NA	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MAG.T21.41_00736	330214.NIDE2372	3.2e-108	398.3	Bacteria	cpaE		2.7.11.1,2.7.13.3	ko:K02282,ko:K02482,ko:K04757,ko:K20977	ko02020,ko02025,map02020,map02025	M00820			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021				Bacteria	COG2172@1,COG2172@2,COG2204@1,COG2204@2	NA|NA|NA	T	sigma factor antagonist activity
MAG.T21.41_00737	330214.NIDE2371	1.2e-34	152.5	Bacteria				ko:K20976	ko02020,ko02025,map02020,map02025	M00820			ko00000,ko00001,ko00002,ko02022				Bacteria	COG2198@1,COG2198@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_00738	330214.NIDE2370	3.6e-182	644.4	Bacteria			3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	COG0745@1,COG0745@2,COG2208@1,COG2208@2	NA|NA|NA	T	phosphoserine phosphatase activity
MAG.T21.41_00739	330214.NIDE2369	6.5e-41	173.3	Bacteria	IV02_16530												Bacteria	COG1366@1,COG1366@2	NA|NA|NA	T	antisigma factor binding
MAG.T21.41_00740	330214.NIDE2368	6.5e-38	163.3	Bacteria				ko:K04749,ko:K17763					ko00000,ko03021				Bacteria	COG1366@1,COG1366@2	NA|NA|NA	T	antisigma factor binding
MAG.T21.41_00741	330214.NIDE2367	6.5e-169	600.1	Nitrospirae	cheB		3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	3J0X3@40117,COG2201@1,COG2201@2	NA|NA|NA	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MAG.T21.41_00742	330214.NIDE2366	1.2e-101	375.9	Bacteria	cheD	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896	3.1.1.61,3.5.1.44	ko:K03411,ko:K03412	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	COG1871@1,COG1871@2	NA|NA|NA	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MAG.T21.41_00743	330214.NIDE2365	3.9e-25	119.8	Nitrospirae	cheR	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko01000,ko02035				Bacteria	3J0XI@40117,COG1352@1,COG1352@2	NA|NA|NA	NT	Chemotaxis protein methyltransferase
MAG.T21.41_00744	330214.NIDE3165	0.0	1384.0	Bacteria	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K06959					ko00000				Bacteria	COG2183@1,COG2183@2	NA|NA|NA	K	obsolete transcription factor activity, core RNA polymerase II binding
MAG.T21.41_00745	330214.NIDE3168	9.4e-20	102.1	Bacteria	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216					ko00000,ko01000,ko03016				Bacteria	COG0219@1,COG0219@2	NA|NA|NA	J	wobble position uridine ribose methylation
MAG.T21.41_00746	330214.NIDE3114	8e-177	626.3	Bacteria	bfmBA		1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0022@1,COG0022@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAG.T21.41_00747	330214.NIDE3115	3.7e-149	534.6	Bacteria	bfmBB		2.3.1.168,2.3.1.61	ko:K00658,ko:K09699	ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00036	R02570,R02571,R02662,R03174,R04097,R08549,R10998	RC00004,RC02727,RC02833,RC02870	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0508@1,COG0508@2	NA|NA|NA	C	S-acyltransferase activity
MAG.T21.41_00748	330214.NIDE3116	3.2e-180	637.9	Bacteria	atoB		2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147			iJN746.PP_2215	Bacteria	COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T21.41_00752	330214.NIDE1412	1.7e-47	195.3	Bacteria			1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_00753	330214.NIDE1411	5.2e-281	973.0	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00754	330214.NIDE1410	3.1e-117	428.3	Nitrospirae	aroB		3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	3J0K5@40117,COG0248@1,COG0248@2	NA|NA|NA	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00756	330214.NIDE1408	0.0	1285.8	Nitrospirae	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0E8@40117,COG1200@1,COG1200@2	NA|NA|NA	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MAG.T21.41_00759	330214.NIDE4173	1.8e-287	994.6	Bacteria													Bacteria	COG2220@1,COG2220@2	NA|NA|NA	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity
MAG.T21.41_00760	330214.NIDE4174	3.3e-64	251.1	Bacteria													Bacteria	COG0346@1,COG0346@2	NA|NA|NA	E	lactoylglutathione lyase activity
MAG.T21.41_00761	330214.NIDE4175	8.6e-156	556.2	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00762	330214.NIDE4176	1.8e-121	442.2	Bacteria	hemD		2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1587@1,COG1587@2	NA|NA|NA	H	uroporphyrinogen-III synthase activity
MAG.T21.41_00763	330214.NIDE4178	3.6e-163	580.9	Bacteria													Bacteria	COG1262@1,COG1262@2	NA|NA|NA	T	PFAM Formylglycine-generating sulfatase enzyme
MAG.T21.41_00764	330214.NIDE4179	1.4e-99	369.0	Bacteria				ko:K03598					ko00000,ko03021				Bacteria	COG3026@1,COG3026@2	NA|NA|NA	T	antisigma factor binding
MAG.T21.41_00765	330214.NIDE4180	2e-101	375.2	Bacteria	Cj0420												Bacteria	COG2353@1,COG2353@2	NA|NA|NA	O	YceI-like domain
MAG.T21.41_00766	330214.NIDE4181	3.7e-137	494.6	Bacteria			2.7.13.3	ko:K03407,ko:K03832	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035	2.C.1.1			Bacteria	COG0810@1,COG0810@2	NA|NA|NA	M	energy transducer activity
MAG.T21.41_00767	330214.NIDE4183	1.2e-186	659.1	Bacteria	tdh		1.1.1.103,2.7.13.3	ko:K00060,ko:K07777	ko00260,ko02020,map00260,map02020	M00478	R01465	RC00525	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG1063@1,COG1063@2	NA|NA|NA	E	alcohol dehydrogenase
MAG.T21.41_00768	330214.NIDE4184	1.7e-189	668.7	Nitrospirae	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007			iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iPC815.YPO0059,iWFL_1372.ECW_m3896	Bacteria	3J0XU@40117,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MAG.T21.41_00769	330214.NIDE4185	9.1e-141	506.5	Bacteria	vacJ			ko:K04754					ko00000				Bacteria	COG2853@1,COG2853@2	NA|NA|NA	M	Lipoprotein
MAG.T21.41_00770	330214.NIDE4187	1e-131	476.1	Bacteria	mhpC			ko:K06889					ko00000				Bacteria	COG1073@1,COG1073@2	NA|NA|NA	S	thiolester hydrolase activity
MAG.T21.41_00771	330214.NIDE1885	8.5e-23	114.0	Bacteria				ko:K16079					ko00000,ko02000	1.B.4.2.1			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_00772	697282.Mettu_3255	2.2e-19	101.7	Gammaproteobacteria													Bacteria	1NA5N@1224,1SE9F@1236,2E7TI@1,333ZE@2	NA|NA|NA	S	TRL-like protein family
MAG.T21.41_00773	330214.NIDE4188	1.7e-306	1058.1	Bacteria													Bacteria	28J7E@1,2Z92U@2	NA|NA|NA	S	Domain of unknown function (DUF4105)
MAG.T21.41_00774	671143.DAMO_0159	5.9e-59	233.8	Bacteria													Bacteria	2DMP9@1,32SV1@2	NA|NA|NA	S	Protein of unknown function (DUF3015)
MAG.T21.41_00775	240015.ACP_0636	1.9e-08	64.7	Acidobacteriia				ko:K07095					ko00000				Bacteria	2JJEG@204432,3Y51P@57723,COG0622@1,COG0622@2	NA|NA|NA	S	Calcineurin-like phosphoesterase superfamily domain
MAG.T21.41_00776	330214.NIDE4080	9.3e-125	453.0	Nitrospirae	arnC		2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	3J13C@40117,COG0463@1,COG0463@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T21.41_00777	330214.NIDE4081	2.2e-45	188.0	Bacteria													Bacteria	COG3952@1,COG3952@2	NA|NA|NA	S	lipid-A-disaccharide synthase activity
MAG.T21.41_00778	330214.NIDE4082	1.6e-305	1054.7	Nitrospirae													Bacteria	3J12H@40117,COG1807@1,COG1807@2	NA|NA|NA	M	Dolichyl-phosphate-mannose-protein mannosyltransferase
MAG.T21.41_00779	330214.NIDE4083	5.8e-112	411.0	Nitrospirae	lpxE		3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100		R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011				Bacteria	3J1CX@40117,COG0671@1,COG0671@2	NA|NA|NA	I	PAP2 superfamily
MAG.T21.41_00780	330214.NIDE4084	3.6e-173	614.4	Bacteria	tolB			ko:K03641					ko00000,ko02000	2.C.1.2			Bacteria	COG0823@1,COG0823@2	NA|NA|NA	U	Involved in the tonB-independent uptake of proteins
MAG.T21.41_00781	330214.NIDE4085	0.0	1089.3	Bacteria												iAF987.Gmet_0348	Bacteria	COG0308@1,COG0308@2	NA|NA|NA	E	peptide catabolic process
MAG.T21.41_00782	330214.NIDE4086	5.4e-120	437.2	Bacteria													Bacteria	COG0745@1,COG0745@2,COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_00783	330214.NIDE4087	5.7e-153	547.0	Nitrospirae	ftsY	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7			Bacteria	3J0GY@40117,COG0552@1,COG0552@2	NA|NA|NA	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MAG.T21.41_00784	330214.NIDE4088	1e-54	219.5	Nitrospirae	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029				Bacteria	3J0US@40117,COG0319@1,COG0319@2	NA|NA|NA	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MAG.T21.41_00785	330214.NIDE4089	1.6e-170	605.5	Nitrospirae	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06217					ko00000				Bacteria	3J0AD@40117,COG1702@1,COG1702@2	NA|NA|NA	T	PhoH-like protein
MAG.T21.41_00786	330214.NIDE4090	1.6e-121	442.6	Bacteria													Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
MAG.T21.41_00787	330214.NIDE4091	0.0	2117.0	Nitrospirae	pilY1-2			ko:K02674					ko00000,ko02035,ko02044				Bacteria	3J100@40117,COG3419@1,COG3419@2	NA|NA|NA	NU	Tfp pilus assembly protein tip-associated adhesin
MAG.T21.41_00788	571166.KI421509_gene1188	3.5e-64	251.1	Alphaproteobacteria													Bacteria	1QVDY@1224,2TWCV@28211,COG3547@1,COG3547@2	NA|NA|NA	L	Protein of unknown function (DUF2924)
MAG.T21.41_00791	1470591.BW41_02791	2.4e-39	168.7	Sphingomonadales				ko:K03892					ko00000,ko03000				Bacteria	1RJSB@1224,2K86J@204457,2UDRF@28211,COG0640@1,COG0640@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_00792	1121271.AUCM01000015_gene2502	2.9e-08	64.3	Alphaproteobacteria													Bacteria	1N4KK@1224,2E1JA@1,2UE7I@28211,32WWZ@2	NA|NA|NA		
MAG.T21.41_00793	1469613.JT55_06000	2.5e-63	248.8	Alphaproteobacteria													Bacteria	1R4JD@1224,2TVCE@28211,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70, region 4
MAG.T21.41_00794	1333998.M2A_3395	4.1e-42	178.3	Alphaproteobacteria													Bacteria	1N2Y5@1224,2AK7J@1,2U9GR@28211,31AXS@2	NA|NA|NA		
MAG.T21.41_00796	330214.NIDE2287	1.7e-37	161.8	Nitrospirae	fliE			ko:K02408	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0UT@40117,COG1677@1,COG1677@2	NA|NA|NA	N	Flagellar hook-basal body complex protein FliE
MAG.T21.41_00797	330214.NIDE2286	1.6e-71	275.4	Nitrospirae	flgC	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02388	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0TK@40117,COG1558@1,COG1558@2	NA|NA|NA	N	Belongs to the flagella basal body rod proteins family
MAG.T21.41_00798	330214.NIDE2285	3.3e-60	237.7	Nitrospirae	flgB			ko:K02387	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0R3@40117,COG1815@1,COG1815@2	NA|NA|NA	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
MAG.T21.41_00799	330214.NIDE2284	8e-239	832.8	Nitrospirae	atoC			ko:K07713,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00499,M00500,M00515			ko00000,ko00001,ko00002,ko02022				Bacteria	3J0FP@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_00800	330214.NIDE2283	1.6e-177	629.0	Bacteria	gnfL		2.7.13.3	ko:K07708,ko:K07710,ko:K10942	ko02020,ko05111,map02020,map05111	M00497,M00500,M00515			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG3852@1,COG3852@2	NA|NA|NA	T	phosphorelay sensor kinase activity
MAG.T21.41_00801	1121438.JNJA01000002_gene3791	2.7e-11	77.4	Desulfovibrionales	slt			ko:K07114,ko:K08309					ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23		Bacteria	1R5H0@1224,2M7TT@213115,2WM7U@28221,42PMR@68525,COG0457@1,COG0457@2,COG1729@1,COG1729@2	NA|NA|NA	K	repeat-containing protein
MAG.T21.41_00802	330214.NIDE2280	9.4e-256	889.0	Bacteria	fleQ			ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111				ko00000,ko00001,ko03000				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_00804	102129.Lepto7375DRAFT_0018	9.2e-33	147.9	Bacteria													Bacteria	COG1002@1,COG1002@2	NA|NA|NA	V	DNA modification
MAG.T21.41_00805	519989.ECTPHS_14004	5.8e-138	497.7	Chromatiales													Bacteria	1MVI1@1224,1RQP7@1236,1WVZP@135613,COG3344@1,COG3344@2	NA|NA|NA	L	reverse transcriptase
MAG.T21.41_00806	146922.JOFU01000020_gene2515	1.3e-138	500.0	Actinobacteria													Bacteria	2GRDZ@201174,COG5361@1,COG5361@2	NA|NA|NA	S	Protein of unknown function (DUF1254)
MAG.T21.41_00807	371731.Rsw2DRAFT_0144	0.0	1415.2	Alphaproteobacteria	aoxB		1.20.2.1,1.20.9.1	ko:K08356					ko00000,ko01000,ko02000	5.A.3.6			Bacteria	1MX0A@1224,2TRN3@28211,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MAG.T21.41_00808	1197906.CAJQ02000011_gene927	4.2e-68	264.2	Bradyrhizobiaceae	aoxA		1.20.2.1,1.20.9.1	ko:K08355					ko00000,ko01000,ko02000	5.A.3.6			Bacteria	1RF8Q@1224,2U5KE@28211,3JY3T@41294,COG0723@1,COG0723@2	NA|NA|NA	C	Rieske [2Fe-2S] domain
MAG.T21.41_00809	1211115.ALIQ01000219_gene1391	6.6e-126	457.6	Alphaproteobacteria				ko:K07714	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	1MU0N@1224,2TQPG@28211,COG2204@1,COG2204@2	NA|NA|NA	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains
MAG.T21.41_00810	1207063.P24_08314	1.7e-103	383.3	Rhodospirillales													Bacteria	1PTNW@1224,2JQZF@204441,2TRTN@28211,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_00811	330214.NIDE0277	1.5e-117	429.1	Bacteria				ko:K07289					ko00000				Bacteria	COG2982@1,COG2982@2	NA|NA|NA	M	Protein involved in outer membrane biogenesis
MAG.T21.41_00812	330214.NIDE0276	3e-126	458.0	Nitrospirae				ko:K03442,ko:K22044					ko00000,ko02000	1.A.23.2,1.A.23.3			Bacteria	3J0R7@40117,COG3264@1,COG3264@2	NA|NA|NA	M	Mechanosensitive ion channel
MAG.T21.41_00813	330214.NIDE0275	4.2e-75	287.7	Bacteria	rmuC			ko:K09760					ko00000				Bacteria	COG1322@1,COG1322@2	NA|NA|NA	S	DNA recombination
MAG.T21.41_00815	330214.NIDE0274	1.9e-210	738.8	Bacteria				ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6			Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_00816	330214.NIDE0273	7.3e-68	263.5	Bacteria													Bacteria	COG1100@1,COG1100@2	NA|NA|NA	S	GTP binding
MAG.T21.41_00817	330214.NIDE0271	1.9e-253	881.7	Bacteria													Bacteria	COG3829@1,COG3829@2	NA|NA|NA	T	transcription factor binding
MAG.T21.41_00818	330214.NIDE0270	9.6e-31	139.8	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_00819	330214.NIDE0268	6.4e-191	673.3	Bacteria													Bacteria	COG3137@1,COG3137@2	NA|NA|NA		
MAG.T21.41_00820	330214.NIDE0267	1.3e-59	235.7	Nitrospirae	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066		ko:K03282					ko00000,ko02000	1.A.22.1			Bacteria	3J19K@40117,COG1970@1,COG1970@2	NA|NA|NA	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MAG.T21.41_00821	330214.NIDE0266	9.1e-98	364.0	Bacteria	motB			ko:K02557,ko:K21471	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko02035	1.A.30.1			Bacteria	COG1360@1,COG1360@2,COG4942@1,COG4942@2	NA|NA|NA	N	Flagellar Motor Protein
MAG.T21.41_00822	330214.NIDE0265	1.9e-105	389.8	Bacteria	ebh		2.1.1.80,3.1.1.61	ko:K02557,ko:K07484,ko:K13924,ko:K21471	ko02020,ko02030,ko02040,map02020,map02030,map02040	M00506			ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02000,ko02022,ko02035	1.A.30.1			Bacteria	COG1360@1,COG1360@2,COG4372@1,COG4372@2	NA|NA|NA	Q	Transposase
MAG.T21.41_00823	330214.NIDE0264	2.2e-179	635.2	Bacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems, periplasmic component
MAG.T21.41_00824	330214.NIDE0263	1.5e-155	555.8	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00826	330214.NIDE0262	3.2e-213	747.7	Nitrospirae	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K03545					ko00000				Bacteria	3J12E@40117,COG0544@1,COG0544@2	NA|NA|NA	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MAG.T21.41_00827	330214.NIDE0261	8e-114	416.4	Nitrospirae	clpP	GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0A3@40117,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MAG.T21.41_00828	330214.NIDE0260	1.7e-232	811.6	Nitrospirae	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03544	ko04112,map04112				ko00000,ko00001,ko03110				Bacteria	3J0AM@40117,COG1219@1,COG1219@2	NA|NA|NA	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MAG.T21.41_00829	330214.NIDE0258	4.2e-84	317.4	Bacteria				ko:K02676					ko00000,ko02035,ko02044				Bacteria	COG3215@1,COG3215@2	NA|NA|NA	NU	PilZ domain
MAG.T21.41_00830	330214.NIDE0257	2.3e-74	285.0	Bacteria				ko:K02676					ko00000,ko02035,ko02044				Bacteria	COG3215@1,COG3215@2	NA|NA|NA	NU	PilZ domain
MAG.T21.41_00831	330214.NIDE0256	6.6e-18	97.8	Bacteria	cpeZ			ko:K05386	ko00196,ko01100,map00196,map01100				ko00000,ko00001,ko00194				Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_00832	330214.NIDE0255	2.7e-112	411.8	Bacteria	tatA			ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	COG1826@1,COG1826@2	NA|NA|NA	U	protein secretion
MAG.T21.41_00833	330214.NIDE0254	3.2e-191	674.5	Bacteria			3.4.11.9	ko:K01262					ko00000,ko01000,ko01002				Bacteria	COG0006@1,COG0006@2	NA|NA|NA	E	proline dipeptidase activity
MAG.T21.41_00835	1283300.ATXB01000001_gene259	2.5e-11	75.5	Bacteria													Bacteria	2DGQ2@1,2ZWWE@2	NA|NA|NA		
MAG.T21.41_00836	330214.NIDE0251	3.7e-121	441.0	Nitrospirae	puuD	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0033969,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	3.5.1.94,4.1.3.27	ko:K01658,ko:K07010,ko:K09473	ko00330,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00330,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00136	R00985,R00986,R07419	RC00010,RC00090,RC00096,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	3J0PV@40117,COG2071@1,COG2071@2	NA|NA|NA	S	Peptidase C26
MAG.T21.41_00837	330214.NIDE0250	1.2e-234	818.9	Nitrospirae	yeeF			ko:K03294					ko00000	2.A.3.2			Bacteria	3J0ZY@40117,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T21.41_00840	330214.NIDE0246	1.8e-193	681.8	Nitrospirae	nagZ		3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0MK@40117,COG1472@1,COG1472@2	NA|NA|NA	G	Glycosyl hydrolase family 3 N terminal domain
MAG.T21.41_00841	330214.NIDE0245	1.5e-267	928.3	Nitrospirae	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.5	ko:K01255,ko:K01259	ko00330,ko00480,ko01100,map00330,map00480,map01100		R00135,R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	3J0X7@40117,COG0260@1,COG0260@2	NA|NA|NA	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MAG.T21.41_00842	330214.NIDE0244	1.3e-100	372.5	Nitrospirae	queE		1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100		R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016			iAF987.Gmet_1658	Bacteria	3J0M2@40117,COG0602@1,COG0602@2	NA|NA|NA	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MAG.T21.41_00843	330214.NIDE0243	3.6e-107	394.4	Bacteria													Bacteria	COG0560@1,COG0560@2	NA|NA|NA	E	Phosphoserine phosphatase
MAG.T21.41_00845	330214.NIDE0241	1.1e-196	693.0	Bacteria			2.7.13.3	ko:K10942	ko02020,ko05111,map02020,map05111	M00515			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG2202@1,COG2202@2,COG3852@1,COG3852@2	NA|NA|NA	T	phosphorelay sensor kinase activity
MAG.T21.41_00846	56780.SYN_00173	3e-28	131.3	Deltaproteobacteria													Bacteria	1QUK7@1224,2WW6W@28221,431U0@68525,COG0784@1,COG0784@2	NA|NA|NA	T	PFAM response regulator receiver
MAG.T21.41_00848	330214.NIDE0238	1.1e-267	929.5	Nitrospirae	priA			ko:K04066	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0MZ@40117,COG1198@1,COG1198@2	NA|NA|NA	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MAG.T21.41_00850	330214.NIDE0237	2.9e-197	694.9	Bacteria				ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	COG1360@1,COG1360@2	NA|NA|NA	N	Flagellar Motor Protein
MAG.T21.41_00852	330214.NIDE0236	1.7e-63	248.4	Bacteria	nuoA		1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	COG0838@1,COG0838@2	NA|NA|NA	C	NADH dehydrogenase (ubiquinone) activity
MAG.T21.41_00853	330214.NIDE0235	8.2e-96	356.3	Nitrospirae	nuoB		1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J11S@40117,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00854	330214.NIDE0234	3.8e-87	327.4	Nitrospirae	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iAF987.Gmet_3353	Bacteria	3J168@40117,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00855	330214.NIDE0233	1.5e-244	851.7	Nitrospirae	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0FM@40117,COG0649@1,COG0649@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00856	330214.NIDE0232	0.0	1666.0	Nitrospirae	hcnA		1.4.99.5,1.5.3.1	ko:K00302,ko:K10814	ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110		R00374,R00610,R05704	RC00060,RC00557,RC02808	ko00000,ko00001,ko01000,ko02042				Bacteria	3J0UR@40117,COG3383@1,COG3383@2	NA|NA|NA	C	Molydopterin dinucleotide binding domain
MAG.T21.41_00857	330214.NIDE0231	2.7e-100	371.3	Nitrospirae	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3,1.6.99.3	ko:K00338,ko:K02573,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6			Bacteria	3J0N0@40117,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00858	330214.NIDE0230	7.4e-81	306.6	Bacteria	nuoJ		1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	COG0839@1,COG0839@2	NA|NA|NA	C	Belongs to the complex I subunit 6 family
MAG.T21.41_00859	330214.NIDE0229	2.1e-40	171.4	Nitrospirae	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J1AK@40117,COG0713@1,COG0713@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00860	330214.NIDE0228	0.0	1278.1	Nitrospirae			1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0AN@40117,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-quinone oxidoreductase
MAG.T21.41_00861	330214.NIDE0227	1.8e-268	931.4	Nitrospirae	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0EQ@40117,COG1008@1,COG1008@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00862	330214.NIDE0226	1.9e-292	1011.1	Nitrospirae	ndhD		1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iJN678.ndhD2	Bacteria	3J0EQ@40117,COG1008@1,COG1008@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00863	330214.NIDE0225	3.5e-253	880.6	Nitrospirae	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343,ko:K05573	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iJN678.ndhB	Bacteria	3J0FN@40117,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_00864	330214.NIDE0224	4.9e-202	710.7	Nitrospirae													Bacteria	3J12S@40117,COG4251@1,COG4251@2,COG5278@1,COG5278@2	NA|NA|NA	T	CHASE3 domain
MAG.T21.41_00865	330214.NIDE0223	3.2e-75	287.7	Nitrospirae													Bacteria	3J151@40117,COG0745@1,COG0745@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T21.41_00866	330214.NIDE0222	4.7e-267	926.8	Nitrospirae													Bacteria	3J10H@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_00867	330214.NIDE0221	7.6e-129	466.8	Bacteria													Bacteria	COG3698@1,COG3698@2	NA|NA|NA	S	Phosphodiester glycosidase
MAG.T21.41_00868	330214.NIDE0220	7.6e-60	236.5	Bacteria													Bacteria	COG0607@1,COG0607@2	NA|NA|NA	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAG.T21.41_00870	330214.NIDE0218	1.5e-61	242.3	Nitrospirae	pyrE		2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000			iJN678.umpS	Bacteria	3J0T8@40117,COG0461@1,COG0461@2	NA|NA|NA	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MAG.T21.41_00871	330214.NIDE2453	1.3e-68	265.8	Nitrospirae	hsp			ko:K13993	ko04141,map04141				ko00000,ko00001,ko03110				Bacteria	3J0TV@40117,COG0071@1,COG0071@2	NA|NA|NA	O	Belongs to the small heat shock protein (HSP20) family
MAG.T21.41_00873	330214.NIDE2451	1.4e-214	751.9	Bacteria	gltA		2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000			iJN678.gltA	Bacteria	COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T21.41_00876	330214.NIDE2447	9.1e-51	206.1	Bacteria	arsC		1.20.4.1	ko:K00537					ko00000,ko01000				Bacteria	COG1393@1,COG1393@2	NA|NA|NA	P	arsenate reductase (glutaredoxin) activity
MAG.T21.41_00878	330214.NIDE2445	2.3e-210	738.0	Bacteria	rnd		3.1.13.5	ko:K03684					ko00000,ko01000,ko03016				Bacteria	COG0349@1,COG0349@2	NA|NA|NA	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MAG.T21.41_00879	330214.NIDE2444	2.3e-88	331.6	Bacteria	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363		ko:K05516,ko:K05801,ko:K18481		M00670			ko00000,ko00002,ko02000,ko03036,ko03110	3.A.1.27.4,3.A.1.27.5			Bacteria	COG0484@1,COG0484@2	NA|NA|NA	O	heat shock protein binding
MAG.T21.41_00880	330214.NIDE2443	1.2e-217	762.3	Bacteria	CP_0904												Bacteria	COG1055@1,COG1055@2	NA|NA|NA	P	arsenite transmembrane transporter activity
MAG.T21.41_00881	330214.NIDE2442	3.2e-251	874.0	Nitrospirae	me		1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020		R00214	RC00105	ko00000,ko00001,ko01000				Bacteria	3J0WV@40117,COG0281@1,COG0281@2	NA|NA|NA	C	Malic enzyme, NAD binding domain
MAG.T21.41_00883	330214.NIDE2440	0.0	2001.1	Nitrospirae	yyaL			ko:K06888					ko00000				Bacteria	3J0HX@40117,COG0667@1,COG0667@2,COG1331@1,COG1331@2	NA|NA|NA	O	Protein of unknown function, DUF255
MAG.T21.41_00884	1121920.AUAU01000008_gene1617	1.1e-14	86.3	Bacteria	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373,ko:K17052	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Bacteria	COG2180@1,COG2180@2	NA|NA|NA	C	chaperone-mediated protein complex assembly
MAG.T21.41_00885	1121920.AUAU01000008_gene1616	8.7e-48	197.2	Bacteria	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1		iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Bacteria	COG2181@1,COG2181@2	NA|NA|NA	C	nitrate reductase activity
MAG.T21.41_00886	1121920.AUAU01000008_gene1615	1.1e-41	176.8	Acidobacteria	actA			ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002				Bacteria	3Y9EA@57723,COG3303@1,COG3303@2	NA|NA|NA	P	Cytochrome c7 and related cytochrome c
MAG.T21.41_00887	264462.Bd1582	1.4e-09	69.3	Bdellovibrionales	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	1RCWT@1224,2MT2P@213481,2WNAN@28221,42TV9@68525,COG0629@1,COG0629@2	NA|NA|NA	L	Single-strand binding protein family
MAG.T21.41_00889	264732.Moth_0675	4.7e-61	243.0	Clostridia	helD		3.6.4.12,5.99.1.2	ko:K03168,ko:K03658,ko:K06131	ko00564,ko01100,map00564,map01100		R07390	RC00017	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	1UNF1@1239,24HXY@186801,COG0507@1,COG0507@2,COG0551@1,COG0551@2,COG1112@1,COG1112@2,COG1502@1,COG1502@2	NA|NA|NA	L	AAA domain
MAG.T21.41_00890	670307.HYPDE_23088	7.9e-46	190.3	Bacteria			2.3.1.189	ko:K15520					ko00000,ko01000				Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_00891	32057.KB217478_gene2345	1.9e-15	88.6	Nostocales													Bacteria	1G7VQ@1117,1HPXY@1161,COG4453@1,COG4453@2	NA|NA|NA	S	Protein of unknown function (DUF1778)
MAG.T21.41_00895	1408254.T458_08805	1.8e-32	145.2	Paenibacillaceae				ko:K06867					ko00000				Bacteria	1V2DE@1239,26WR5@186822,4HGU4@91061,COG0666@1,COG0666@2	NA|NA|NA	S	Ankyrin repeat
MAG.T21.41_00896	330214.NIDE0055	2.8e-136	491.5	Bacteria	oxyR			ko:K04761	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
MAG.T21.41_00898	330214.NIDE0057	1.5e-168	599.0	Nitrospirae	mauG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428					ko00000,ko01000				Bacteria	3J0GH@40117,COG1858@1,COG1858@2	NA|NA|NA	C	Di-haem cytochrome c peroxidase
MAG.T21.41_00899	330214.NIDE0058	1.9e-268	931.4	Bacteria				ko:K08218	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.25			Bacteria	COG2211@1,COG2211@2	NA|NA|NA	G	Major facilitator Superfamily
MAG.T21.41_00900	330214.NIDE0059	1e-152	546.2	Nitrospirae	dedA_2												Bacteria	3J1E4@40117,COG0586@1,COG0586@2,COG0607@1,COG0607@2	NA|NA|NA	P	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00901	1005048.CFU_0763	1.1e-43	184.1	Oxalobacteraceae													Bacteria	1R0XC@1224,2WHXS@28216,475EE@75682,COG0640@1,COG0640@2	NA|NA|NA	K	STAS-like domain of unknown function (DUF4325)
MAG.T21.41_00903	626887.J057_10026	2.1e-66	259.6	Alteromonadaceae			3.2.1.35	ko:K01197	ko00531,ko01100,map00531,map01100	M00076,M00077	R07824,R07825,R10905		ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042				Bacteria	1QR2G@1224,1RZNM@1236,466IG@72275,COG3525@1,COG3525@2	NA|NA|NA	G	beta-N-acetylglucosaminidase
MAG.T21.41_00904	330214.NIDE2803	4.2e-127	461.1	Bacteria	nodD2												Bacteria	COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
MAG.T21.41_00905	330214.NIDE2804	3.3e-83	314.7	Bacteria	tpm		2.1.1.67	ko:K00569	ko00983,map00983		R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000				Bacteria	COG0500@1,COG0500@2	NA|NA|NA	Q	methyltransferase activity
MAG.T21.41_00906	330214.NIDE2805	2.7e-162	578.6	Nitrospirae	stp_1												Bacteria	3J18B@40117,COG0477@1,COG2814@2	NA|NA|NA	P	Major Facilitator Superfamily
MAG.T21.41_00907	1122951.ATUE01000005_gene2074	3e-18	97.4	Gammaproteobacteria													Bacteria	1N8QY@1224,1SFWC@1236,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T21.41_00908	330214.NIDE0134	1.6e-39	168.7	Bacteria		GO:0002790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030255,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0043684,GO:0044097,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0097159,GO:1901363		ko:K19092					ko00000,ko02048				Bacteria	COG3668@1,COG3668@2	NA|NA|NA	D	Plasmid stabilization system
MAG.T21.41_00909	743299.Acife_0839	7.3e-276	956.1	Proteobacteria			3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MXG1@1224,COG2865@1,COG2865@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_00910	946483.Cenrod_2707	0.0	1562.7	Comamonadaceae	hsdR_1		3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	1QTS7@1224,2VPCW@28216,4AEDZ@80864,COG4096@1,COG4096@2	NA|NA|NA	V	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MAG.T21.41_00911	292564.Cyagr_1940	3.5e-86	325.9	Cyanobacteria			3.1.21.3	ko:K01154					ko00000,ko01000,ko02048				Bacteria	1G322@1117,COG0732@1,COG0732@2	NA|NA|NA	L	Type I restriction modification DNA specificity domain
MAG.T21.41_00912	1286631.X805_28020	3.9e-143	515.0	Betaproteobacteria													Bacteria	1R4MD@1224,2WFIY@28216,COG2865@1,COG2865@2	NA|NA|NA	K	Putative ATP-dependent DNA helicase recG C-terminal
MAG.T21.41_00913	946483.Cenrod_2703	7.5e-264	916.0	Comamonadaceae			2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	1MW3A@1224,2VIP4@28216,4ABKU@80864,COG0286@1,COG0286@2	NA|NA|NA	V	N-6 DNA Methylase
MAG.T21.41_00914	330214.NIDE0140	4.3e-95	354.0	Bacteria	MA20_21045												Bacteria	COG5514@1,COG5514@2	NA|NA|NA		
MAG.T21.41_00917	330214.NIDE0143	0.0	1197.2	Bacteria			3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100		R01790,R01791,R06199		ko00000,ko00001,ko01000		GH15		Bacteria	COG3387@1,COG3387@2	NA|NA|NA	G	glucan 1,4-alpha-glucosidase activity
MAG.T21.41_00920	330214.NIDE1585	1e-199	702.6	Nitrospirae				ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	3J0C2@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_00921	330214.NIDE1584	1.8e-180	638.6	Nitrospirae	MA20_23615			ko:K07814					ko00000,ko02022				Bacteria	3J0ID@40117,COG3437@1,COG3437@2	NA|NA|NA	T	response regulator
MAG.T21.41_00922	330214.NIDE1583	1.1e-239	835.9	Nitrospirae	recN	GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360		ko:K03631,ko:K13582	ko04112,map04112				ko00000,ko00001,ko03400				Bacteria	3J0HU@40117,COG0497@1,COG0497@2	NA|NA|NA	L	May be involved in recombinational repair of damaged DNA
MAG.T21.41_00923	330214.NIDE1582	9.9e-58	229.2	Nitrospirae	trxA			ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko03110			iIT341.HP0824	Bacteria	3J0P6@40117,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin-like domain
MAG.T21.41_00925	330214.NIDE1580	0.0	1565.1	Nitrospirae	lptD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659		ko:K04744,ko:K09774,ko:K22110					ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1		iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260	Bacteria	3J0QI@40117,COG1452@1,COG1452@2	NA|NA|NA	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MAG.T21.41_00926	330214.NIDE1579	9.9e-183	646.4	Nitrospirae	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K01932,ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2475,iJN746.PP_1997,iSDY_1059.SDY_2514	Bacteria	3J0I6@40117,COG0285@1,COG0285@2	NA|NA|NA	H	Mur ligase middle domain
MAG.T21.41_00927	330214.NIDE1577	7.5e-152	543.1	Nitrospirae	accD		2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iJN678.accD	Bacteria	3J0CK@40117,COG0777@1,COG0777@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MAG.T21.41_00928	330214.NIDE1576	1.7e-121	442.2	Nitrospirae			3.1.26.11,3.1.4.17	ko:K00784,ko:K01120	ko00230,ko03013,map00230,map03013		R00191,R01234	RC00296	ko00000,ko00001,ko01000,ko03016				Bacteria	3J14I@40117,COG1234@1,COG1234@2	NA|NA|NA	S	Beta-lactamase superfamily domain
MAG.T21.41_00929	330214.NIDE1575	3.2e-95	354.8	Bacteria	ureH												Bacteria	COG2215@1,COG2215@2	NA|NA|NA	O	Belongs to the NiCoT transporter (TC 2.A.52) family
MAG.T21.41_00930	330214.NIDE1574	3.6e-191	674.1	Nitrospirae	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000				Bacteria	3J0PB@40117,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAG.T21.41_00931	330214.NIDE1573	1.3e-73	282.3	Nitrospirae	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867	Bacteria	3J1AN@40117,COG0314@1,COG0314@2	NA|NA|NA	H	MoaE protein
MAG.T21.41_00932	330214.NIDE1572	1.1e-34	152.5	Bacteria	moaD			ko:K03636	ko04122,map04122				ko00000,ko00001				Bacteria	COG1977@1,COG1977@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T21.41_00933	330214.NIDE1571	1.2e-75	289.3	Nitrospirae	moaC	GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Bacteria	3J0PN@40117,COG0315@1,COG0315@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MAG.T21.41_00936	330214.NIDE1559	1.8e-102	379.4	Bacteria	MA20_08550			ko:K15539					ko00000				Bacteria	COG4395@1,COG4395@2	NA|NA|NA	S	Tim44
MAG.T21.41_00938	330214.NIDE2513	2.1e-27	127.9	Bacteria													Bacteria	2DGSC@1,2ZX3U@2	NA|NA|NA		
MAG.T21.41_00940	330214.NIDE1554	5.1e-18	96.7	Bacteria													Bacteria	COG1598@1,COG1598@2	NA|NA|NA	N	PFAM Uncharacterised protein family UPF0150
MAG.T21.41_00941	335543.Sfum_0979	1.2e-54	219.9	Deltaproteobacteria				ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Bacteria	1RDXY@1224,2X6GD@28221,43DN5@68525,COG1596@1,COG1596@2	NA|NA|NA	M	PFAM Polysaccharide export protein
MAG.T21.41_00942	330214.NIDE3012	1.4e-160	572.4	Nitrospirae	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	3J0YR@40117,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T21.41_00943	330214.NIDE2386	3.3e-240	837.8	Bacteria													Bacteria	COG5360@1,COG5360@2	NA|NA|NA	S	Heparinase II/III-like protein
MAG.T21.41_00944	396588.Tgr7_2443	6.2e-32	143.7	Gammaproteobacteria	vapC												Bacteria	1N9JM@1224,1SYAP@1236,COG5611@1,COG5611@2	NA|NA|NA	S	PIN domain
MAG.T21.41_00945	221288.JH992901_gene2711	1.7e-16	91.7	Stigonemataceae													Bacteria	1G9J8@1117,1JJ0Y@1189,COG2002@1,COG2002@2	NA|NA|NA	K	SpoVT / AbrB like domain
MAG.T21.41_00947	1382359.JIAL01000001_gene240	3.2e-72	278.9	Bacteria				ko:K07133					ko00000				Bacteria	COG1373@1,COG1373@2	NA|NA|NA	V	ATPase (AAA superfamily
MAG.T21.41_00948	330214.NIDE1076	1.4e-209	735.3	Nitrospirae	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0NV@40117,COG0379@1,COG0379@2	NA|NA|NA	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MAG.T21.41_00951	1123392.AQWL01000002_gene1831	1.3e-98	367.1	Betaproteobacteria				ko:K07001					ko00000				Bacteria	1MUI6@1224,2VHA3@28216,COG1752@1,COG1752@2	NA|NA|NA	S	Phospholipase, patatin family
MAG.T21.41_00952	330214.NIDE1069	1.2e-40	172.2	Bacteria													Bacteria	2DJBU@1,32UCQ@2	NA|NA|NA		
MAG.T21.41_00953	330214.NIDE1068	1e-70	272.7	Bacteria	VY92_01935												Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_00954	330214.NIDE1067	0.0	1434.9	Bacteria													Bacteria	2DBJW@1,2Z9P2@2	NA|NA|NA		
MAG.T21.41_00957	497964.CfE428DRAFT_3716	1.6e-179	636.0	Bacteria	nifA			ko:K02584	ko02020,map02020				ko00000,ko00001,ko03000				Bacteria	COG3604@1,COG3604@2	NA|NA|NA	KT	transcription factor binding
MAG.T21.41_00958	530564.Psta_0275	2.7e-44	185.3	Planctomycetes													Bacteria	2IYUM@203682,COG2128@1,COG2128@2	NA|NA|NA	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAG.T21.41_00959	1502850.FG91_02597	3.8e-84	318.2	Alphaproteobacteria													Bacteria	1N48X@1224,2U17G@28211,COG1335@1,COG1335@2	NA|NA|NA	Q	COG1335 Amidases related to nicotinamidase
MAG.T21.41_00960	452637.Oter_0294	1.9e-38	165.2	Bacteria													Bacteria	COG3370@1,COG3370@2	NA|NA|NA	O	peroxiredoxin activity
MAG.T21.41_00961	497964.CfE428DRAFT_3712	1.1e-62	246.5	Verrucomicrobia				ko:K07006					ko00000				Bacteria	46SQM@74201,COG3576@1,COG3576@2	NA|NA|NA	S	Pyridoxamine 5'-phosphate oxidase
MAG.T21.41_00962	330214.NIDE0264	2.7e-150	538.5	Bacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems, periplasmic component
MAG.T21.41_00967	1265503.KB905161_gene3223	1.8e-11	75.5	Colwelliaceae													Bacteria	1PCZH@1224,1S9EN@1236,2Q87C@267889,COG5572@1,COG5572@2	NA|NA|NA	S	Predicted integral membrane protein (DUF2282)
MAG.T21.41_00968	381666.H16_A1821	7.7e-88	330.5	Burkholderiaceae				ko:K09930					ko00000				Bacteria	1K0J2@119060,1MURE@1224,2VKD3@28216,COG3220@1,COG3220@2	NA|NA|NA	S	belongs to the UPF0276 family
MAG.T21.41_00969	381666.H16_A1820	7.3e-24	117.9	Burkholderiaceae													Bacteria	1K4ZZ@119060,1QAP4@1224,2VXJI@28216,COG3219@1,COG3219@2	NA|NA|NA	S	Putative DNA-binding domain
MAG.T21.41_00970	743299.Acife_0770	1.3e-24	119.8	Gammaproteobacteria				ko:K15977					ko00000				Bacteria	1N1VA@1224,1SA1R@1236,COG2259@1,COG2259@2	NA|NA|NA	S	Membrane
MAG.T21.41_00971	438753.AZC_3167	1.6e-129	469.5	Xanthobacteraceae				ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002				Bacteria	1MX9E@1224,2TRK0@28211,3EYQF@335928,COG2041@1,COG2041@2	NA|NA|NA	S	Mo-co oxidoreductase dimerisation domain
MAG.T21.41_00972	330214.NIDE2576	5e-152	544.3	Bacteria				ko:K00185,ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011	5.A.3			Bacteria	COG1196@1,COG1196@2,COG3743@1,COG3743@2	NA|NA|NA	S	rRNA binding
MAG.T21.41_00973	330214.NIDE2575	4.1e-116	424.5	Bacteria				ko:K02051,ko:K03286		M00188			ko00000,ko00002,ko02000	1.B.6,3.A.1.16,3.A.1.17			Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_00975	330214.NIDE0052	2.5e-121	441.8	Bacteria	rnfB			ko:K03616					ko00000				Bacteria	COG0491@1,COG0491@2,COG1141@1,COG1141@2	NA|NA|NA	C	electron transfer activity
MAG.T21.41_00976	330214.NIDE0051	1.2e-88	332.8	Bacteria	alkA		2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	COG0122@1,COG0122@2	NA|NA|NA	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MAG.T21.41_00977	330214.NIDE0050	2.2e-58	231.5	Bacteria													Bacteria	COG0251@1,COG0251@2	NA|NA|NA	J	oxidation-reduction process
MAG.T21.41_00978	330214.NIDE0049	4.8e-86	324.3	Nitrospirae													Bacteria	3J0J6@40117,COG1028@1,COG1028@2	NA|NA|NA	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_00979	330214.NIDE0048	1.5e-97	362.5	Nitrospirae													Bacteria	3J13G@40117,COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_00980	330214.NIDE0047	3e-94	351.3	Bacteria	tdsD												Bacteria	COG0778@1,COG0778@2	NA|NA|NA	C	coenzyme F420-1:gamma-L-glutamate ligase activity
MAG.T21.41_00981	330214.NIDE0044	1.3e-62	245.7	Bacteria	osmC	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748		ko:K04063					ko00000				Bacteria	COG1764@1,COG1764@2	NA|NA|NA	O	response to oxidative stress
MAG.T21.41_00982	330214.NIDE0043	0.0	1175.2	Bacteria													Bacteria	COG1554@1,COG1554@2	NA|NA|NA	G	hydrolase, family 65, central catalytic
MAG.T21.41_00983	330214.NIDE0042	3.5e-119	434.5	Bacteria	pgmB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576	2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6	ko:K01087,ko:K01194,ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100		R00010,R02727,R02728,R02778,R11310	RC00017,RC00049,RC00408	ko00000,ko00001,ko00537,ko01000		GH37,GH65		Bacteria	COG0637@1,COG0637@2	NA|NA|NA	S	phosphonoacetaldehyde hydrolase activity
MAG.T21.41_00985	330214.NIDE0040	5.8e-63	246.9	Bacteria													Bacteria	COG3678@1,COG3678@2	NA|NA|NA	NPTU	ATP-independent chaperone mediated protein folding
MAG.T21.41_00986	330214.NIDE0039	7.7e-43	179.5	Bacteria													Bacteria	COG2329@1,COG2329@2	NA|NA|NA	S	heme oxygenase (decyclizing) activity
MAG.T21.41_00989	330214.NIDE0036	7.4e-78	296.6	Nitrospirae				ko:K15977					ko00000				Bacteria	3J13I@40117,COG2259@1,COG2259@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_00990	330214.NIDE0034	1.9e-190	671.8	Nitrospirae				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	3J115@40117,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T21.41_00991	330214.NIDE0033	8.2e-186	656.4	Nitrospirae				ko:K01992,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	3J0MP@40117,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T21.41_00992	330214.NIDE0032	1.6e-309	1068.1	Bacteria				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG1131@1,COG1131@2	NA|NA|NA	V	ATPase activity
MAG.T21.41_00993	330214.NIDE0031	3.1e-161	574.7	Nitrospirae	yhiI			ko:K01993,ko:K02005					ko00000				Bacteria	3J0TB@40117,COG1566@1,COG1566@2	NA|NA|NA	V	HlyD family secretion protein
MAG.T21.41_00994	330214.NIDE0030	5.3e-72	276.9	Bacteria													Bacteria	COG3678@1,COG3678@2	NA|NA|NA	NPTU	ATP-independent chaperone mediated protein folding
MAG.T21.41_00995	330214.NIDE0029	0.0	1296.6	Bacteria	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132				ko00000,ko00001,ko03000				Bacteria	COG2203@1,COG2203@2,COG3604@1,COG3604@2	NA|NA|NA	KT	transcription factor binding
MAG.T21.41_00996	330214.NIDE0028	1.4e-51	208.8	Bacteria													Bacteria	COG1669@1,COG1669@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T21.41_00999	1169143.KB911037_gene4227	6.3e-167	595.1	Burkholderiaceae				ko:K03556					ko00000,ko03000				Bacteria	1K5E1@119060,1MVZZ@1224,2VXDK@28216,COG2909@1,COG2909@2,COG3629@1,COG3629@2	NA|NA|NA	K	Bacterial transcriptional activator domain
MAG.T21.41_01001	1280947.HY30_03400	4.8e-102	377.5	Hyphomonadaceae	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	1MUX0@1224,2TR8G@28211,43X7W@69657,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T21.41_01002	1280947.HY30_03400	3e-38	164.5	Hyphomonadaceae	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	1MUX0@1224,2TR8G@28211,43X7W@69657,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T21.41_01003	1185652.USDA257_c10680	2.4e-133	481.9	Rhizobiaceae	fcl		1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100		R05692	RC01014	ko00000,ko00001,ko01000				Bacteria	1MUGT@1224,2TRF6@28211,4BANQ@82115,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
MAG.T21.41_01004	330214.NIDE2732	6.4e-172	610.1	Nitrospirae													Bacteria	3J09X@40117,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_01005	330214.NIDE2731	9.7e-157	559.7	Nitrospirae	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0072	Bacteria	3J0G0@40117,COG0182@1,COG0182@2	NA|NA|NA	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MAG.T21.41_01006	330214.NIDE2730	1.4e-69	268.9	Nitrospirae	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131				Bacteria	3J0PH@40117,COG0105@1,COG0105@2	NA|NA|NA	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MAG.T21.41_01007	1168059.KB899087_gene4212	1.4e-91	343.2	Alphaproteobacteria													Bacteria	1MUIZ@1224,2U6K7@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_01008	639283.Snov_3211	1.9e-149	535.4	Xanthobacteraceae	capD		4.2.1.115,5.1.3.2	ko:K13006,ko:K15894,ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291,R09697	RC00289,RC02609	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1MWKY@1224,2TT4K@28211,3F12B@335928,COG1086@1,COG1086@2	NA|NA|NA	M	Polysaccharide biosynthesis protein C-terminal
MAG.T21.41_01009	316057.RPD_0747	2.1e-94	352.4	Bradyrhizobiaceae	rfbD		1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	1PEQX@1224,2U19I@28211,3K20G@41294,COG1091@1,COG1091@2	NA|NA|NA	M	RmlD substrate binding domain
MAG.T21.41_01010	371731.Rsw2DRAFT_0288	1.6e-168	599.0	Rhodobacter	wecB		5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1FD13@1060,1MWZN@1224,2V9J1@28211,COG0381@1,COG0381@2	NA|NA|NA	M	UDP-N-acetylglucosamine 2-epimerase
MAG.T21.41_01012	652103.Rpdx1_0604	0.0	1119.8	Bradyrhizobiaceae			2.5.1.26	ko:K00803,ko:K11472	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146		R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000				Bacteria	1MXTV@1224,2U0T4@28211,3JRE4@41294,COG0277@1,COG0277@2	NA|NA|NA	C	PFAM FAD linked oxidase domain protein
MAG.T21.41_01013	1304878.AUGD01000001_gene529	2.3e-168	598.2	Bradyrhizobiaceae	dppB3			ko:K02033	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Bacteria	1MU8Z@1224,2TR0N@28211,3JUIB@41294,COG0601@1,COG0601@2	NA|NA|NA	EP	Binding-protein-dependent transport system inner membrane component
MAG.T21.41_01014	652103.Rpdx1_0602	2.4e-164	584.7	Bradyrhizobiaceae				ko:K02031,ko:K02034	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Bacteria	1MU26@1224,2VF5U@28211,3JXA1@41294,COG1173@1,COG1173@2	NA|NA|NA	EP	Binding-protein-dependent transport system inner membrane component
MAG.T21.41_01015	652103.Rpdx1_0601	0.0	1144.0	Bradyrhizobiaceae	dppA3			ko:K02035	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Bacteria	1PFW6@1224,2U1GT@28211,3JUHW@41294,COG0747@1,COG0747@2	NA|NA|NA	E	Peptide ABC transporter substrate-binding protein
MAG.T21.41_01016	652103.Rpdx1_0600	1e-187	662.5	Bradyrhizobiaceae	oppD			ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Bacteria	1R4KB@1224,2TR0J@28211,3JRF7@41294,COG0444@1,COG0444@2	NA|NA|NA	EP	Oligopeptide/dipeptide transporter, C-terminal region
MAG.T21.41_01017	1297863.APJF01000010_gene3411	9.8e-194	682.6	Bradyrhizobiaceae	nikV		3.6.3.24	ko:K02031,ko:K02032,ko:K10823,ko:K10824	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Bacteria	1NU4K@1224,2TQTV@28211,3JVB6@41294,COG4608@1,COG4608@2	NA|NA|NA	E	Belongs to the ABC transporter superfamily
MAG.T21.41_01018	652103.Rpdx1_0598	2.6e-194	684.5	Bradyrhizobiaceae	glcF			ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001			iAPECO1_1312.glcF,iJN678.glcF,iUTI89_1310.glcF,ic_1306.glcF	Bacteria	1MWTK@1224,2TR9H@28211,3JSJD@41294,COG0247@1,COG0247@2	NA|NA|NA	C	Cysteine-rich domain
MAG.T21.41_01019	1123255.JHYS01000016_gene1104	1.1e-37	162.2	Comamonadaceae													Bacteria	1N8BS@1224,2DNRM@1,2VWFQ@28216,32YT2@2,4AIS7@80864	NA|NA|NA	S	Protein of unknown function (DUF2442)
MAG.T21.41_01020	857087.Metme_3788	2.2e-194	685.3	Methylococcales	MA20_10900												Bacteria	1MWIV@1224,1RR7N@1236,1XGKM@135618,COG4584@1,COG4584@2	NA|NA|NA	L	PFAM Integrase, catalytic core
MAG.T21.41_01021	395494.Galf_2409	1.1e-109	402.9	Betaproteobacteria	dnaA_2												Bacteria	1MWQX@1224,2VHN6@28216,COG1484@1,COG1484@2	NA|NA|NA	L	PFAM IstB domain protein ATP-binding protein
MAG.T21.41_01024	237727.NAP1_03285	0.0	1162.9	Alphaproteobacteria	yeeA												Bacteria	1MWRH@1224,2TSWZ@28211,COG1002@1,COG1002@2	NA|NA|NA	V	COG1002 Type II restriction enzyme, methylase subunits
MAG.T21.41_01025	330214.NIDE0786	6.9e-89	333.6	Bacteria				ko:K16079					ko00000,ko02000	1.B.4.2.1			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_01027	330214.NIDE0784	2.1e-195	688.3	Bacteria			1.13.11.52	ko:K00463	ko00380,ko01100,ko05143,map00380,map01100,map05143	M00038	R00678,R02702,R02909,R03628	RC00356	ko00000,ko00001,ko00002,ko01000				Bacteria	COG5274@1,COG5274@2	NA|NA|NA	C	heme binding
MAG.T21.41_01028	330214.NIDE0783	2.2e-58	231.5	Nitrospirae	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Bacteria	3J0QR@40117,COG0193@1,COG0193@2	NA|NA|NA	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MAG.T21.41_01030	330214.NIDE2750	4.6e-45	186.8	Nitrospirae	yggX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887											Bacteria	3J1CU@40117,COG2924@1,COG2924@2	NA|NA|NA	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MAG.T21.41_01031	330214.NIDE2751	3.6e-76	290.8	Nitrospirae		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03617,ko:K08999					ko00000				Bacteria	3J0RC@40117,COG1259@1,COG1259@2	NA|NA|NA	S	Bifunctional nuclease
MAG.T21.41_01032	330214.NIDE2752	1.3e-74	285.8	Nitrospirae		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03617,ko:K08999					ko00000				Bacteria	3J0RC@40117,COG1259@1,COG1259@2	NA|NA|NA	S	Bifunctional nuclease
MAG.T21.41_01033	330214.NIDE2753	2e-68	265.0	Nitrospirae	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02871	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0NE@40117,COG0102@1,COG0102@2	NA|NA|NA	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MAG.T21.41_01034	330214.NIDE2754	7e-60	236.5	Nitrospirae	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02996	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0N4@40117,COG0103@1,COG0103@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS9 family
MAG.T21.41_01035	330214.NIDE2755	5.4e-179	633.6	Nitrospirae	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0H9@40117,COG0002@1,COG0002@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAG.T21.41_01036	330214.NIDE2756	5e-189	667.2	Nitrospirae	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1783	Bacteria	3J0B5@40117,COG1364@1,COG1364@2	NA|NA|NA	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MAG.T21.41_01037	330214.NIDE2757	7e-136	490.0	Nitrospirae	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0G9@40117,COG0052@1,COG0052@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS2 family
MAG.T21.41_01038	330214.NIDE2758	4.7e-100	370.5	Nitrospirae	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02357					ko00000,ko03012,ko03029				Bacteria	3J0I2@40117,COG0264@1,COG0264@2	NA|NA|NA	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MAG.T21.41_01039	330214.NIDE2759	1.5e-124	452.2	Nitrospirae	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100		R00158	RC00002	ko00000,ko00001,ko01000			iSB619.SA_RS06240	Bacteria	3J0BE@40117,COG0528@1,COG0528@2	NA|NA|NA	F	Catalyzes the reversible phosphorylation of UMP to UDP
MAG.T21.41_01040	316056.RPC_2461	9.8e-288	996.1	Bradyrhizobiaceae	pacL		3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2			Bacteria	1MUU5@1224,2TRZD@28211,3JR79@41294,COG0474@1,COG0474@2	NA|NA|NA	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC
MAG.T21.41_01041	288000.BBta_3653	2.4e-47	194.9	Alphaproteobacteria													Bacteria	1RIBQ@1224,2U9TC@28211,COG1765@1,COG1765@2	NA|NA|NA	O	Osmc family
MAG.T21.41_01044	1121396.KB893113_gene3204	4.4e-251	874.0	Desulfobacterales				ko:K03546,ko:K19171					ko00000,ko02048,ko03400				Bacteria	1N7NZ@1224,2MKZB@213118,2WNUS@28221,42U9A@68525,COG0419@1,COG0419@2	NA|NA|NA	L	TIGRFAM DNA sulfur modification protein DndD
MAG.T21.41_01045	309799.DICTH_0106	2.9e-10	72.8	Bacteria			2.1.1.72	ko:K00571,ko:K07448					ko00000,ko01000,ko02048				Bacteria	COG1715@1,COG1715@2	NA|NA|NA	V	Restriction endonuclease
MAG.T21.41_01047	1173263.Syn7502_00979	4.4e-61	242.3	Synechococcus			2.1.1.72,3.1.21.3	ko:K01154,ko:K03427					ko00000,ko01000,ko02048				Bacteria	1GPB9@1117,1H2S1@1129,COG0286@1,COG0286@2,COG0732@1,COG0732@2	NA|NA|NA	V	Type I restriction-modification system methyltransferase subunit
MAG.T21.41_01048	1216362.B437_10737	0.0	1195.3	Fusobacteria			2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	37CGU@32066,COG0286@1,COG0286@2	NA|NA|NA	V	Type I restriction enzyme R protein N terminus (HSDR_N)
MAG.T21.41_01051	330214.NIDE0337	8.2e-89	334.0	Bacteria	nicK			ko:K07467					ko00000				Bacteria	COG2946@1,COG2946@2	NA|NA|NA	L	Replication initiation factor
MAG.T21.41_01053	330214.NIDE3072	1.1e-73	282.7	Bacteria	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360		ko:K02860					ko00000,ko03009				Bacteria	COG0806@1,COG0806@2	NA|NA|NA	J	ribosome binding
MAG.T21.41_01054	330214.NIDE3071	6.5e-134	483.4	Nitrospirae	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	3J0JN@40117,COG0336@1,COG0336@2	NA|NA|NA	J	Belongs to the RNA methyltransferase TrmD family
MAG.T21.41_01055	330214.NIDE3070	4.3e-60	237.3	Nitrospirae	rplS	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02884	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0MJ@40117,COG0335@1,COG0335@2	NA|NA|NA	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MAG.T21.41_01056	330214.NIDE3069	4e-95	354.4	Nitrospirae	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	3J0P5@40117,COG0164@1,COG0164@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MAG.T21.41_01057	330214.NIDE3068	1.2e-51	209.1	Nitrospirae	yraN			ko:K07460					ko00000				Bacteria	3J1ER@40117,COG0792@1,COG0792@2	NA|NA|NA	L	Uncharacterised protein family UPF0102
MAG.T21.41_01058	330214.NIDE3067	1.5e-107	395.6	Nitrospirae	ftsE	GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	3J139@40117,COG2884@1,COG2884@2	NA|NA|NA	D	ABC transporter
MAG.T21.41_01059	330214.NIDE3066	1.3e-130	472.6	Nitrospirae	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	3J18Q@40117,COG2177@1,COG2177@2	NA|NA|NA	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily
MAG.T21.41_01060	330214.NIDE3065	9e-191	672.9	Nitrospirae	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944		ko:K21471					ko00000,ko01000,ko01002,ko01011				Bacteria	3J0SP@40117,COG4942@1,COG4942@2	NA|NA|NA	D	Peptidase family M23
MAG.T21.41_01061	330214.NIDE3064	2.1e-233	814.7	Nitrospirae	ctpA		3.4.21.102	ko:K03797					ko00000,ko01000,ko01002				Bacteria	3J09Y@40117,COG0793@1,COG0793@2	NA|NA|NA	M	tail specific protease
MAG.T21.41_01062	384676.PSEEN1500	1.9e-23	114.8	Gammaproteobacteria	capD		4.2.1.115,5.1.3.2	ko:K15894,ko:K17716	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00362	R00291,R09697	RC00289,RC02609	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWKY@1224,1RNQ2@1236,COG1086@1,COG1086@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_01063	1499686.BN1079_01945	1.5e-128	466.1	Gammaproteobacteria	capF		1.1.1.367	ko:K19068					ko00000,ko01000				Bacteria	1MXGB@1224,1RSK7@1236,COG0451@1,COG0451@2,COG1898@1,COG1898@2	NA|NA|NA	GM	COG0451 Nucleoside-diphosphate-sugar epimerases
MAG.T21.41_01070	330214.NIDE3529	2.2e-115	421.8	Nitrospirae				ko:K07799	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	8.A.1			Bacteria	3J11U@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_01071	330214.NIDE2662	5.6e-15	86.3	Nitrospirae	cobD		6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0K4@40117,COG1270@1,COG1270@2	NA|NA|NA	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MAG.T21.41_01072	330214.NIDE2661	8.7e-132	476.9	Nitrospirae	cobD		2.6.1.9,4.1.1.81	ko:K00817,ko:K04720	ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243,R06530	RC00006,RC00517,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007			iAF987.Gmet_0487	Bacteria	3J138@40117,COG0079@1,COG0079@2	NA|NA|NA	E	Aminotransferase class I and II
MAG.T21.41_01073	330214.NIDE2660	1.5e-84	319.3	Bacteria	cbiZ		2.7.1.156,2.7.7.62,3.6.3.34	ko:K02013,ko:K02231	ko00860,ko01100,ko02010,map00860,map01100,map02010	M00122,M00240	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14			Bacteria	COG1865@1,COG1865@2	NA|NA|NA	HP	Adenosylcobinamide amidohydrolase
MAG.T21.41_01074	330214.NIDE2659	6.9e-215	753.4	Nitrospirae	cobQ		6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000			iYL1228.KPN_03184	Bacteria	3J0F3@40117,COG1492@1,COG1492@2	NA|NA|NA	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
MAG.T21.41_01075	330214.NIDE2658	6.2e-118	430.3	Bacteria													Bacteria	COG3267@1,COG3267@2	NA|NA|NA		
MAG.T21.41_01076	330214.NIDE2657	7.6e-61	239.6	Nitrospirae													Bacteria	3J16K@40117,COG0745@1,COG0745@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T21.41_01077	330214.NIDE2656	4.9e-62	243.8	Bacteria	cheW2			ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG0835@1,COG0835@2	NA|NA|NA	NT	chemotaxis
MAG.T21.41_01078	330214.NIDE2655	8.3e-300	1035.8	Nitrospirae	mcp64H-2			ko:K02660,ko:K03406,ko:K11525	ko02020,ko02025,ko02030,map02020,map02025,map02030				ko00000,ko00001,ko02035,ko02044				Bacteria	3J11V@40117,COG0840@1,COG0840@2,COG2972@1,COG2972@2	NA|NA|NA	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
MAG.T21.41_01079	330214.NIDE2654	0.0	1649.0	Nitrospirae	cheA		2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	3J0WW@40117,COG0643@1,COG0643@2,COG0745@1,COG0745@2,COG2198@1,COG2198@2	NA|NA|NA	T	Two component signalling adaptor domain
MAG.T21.41_01081	330214.NIDE3674	1.4e-95	355.9	Bacteria			3.6.1.27	ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Bacteria	COG0671@1,COG0671@2	NA|NA|NA	I	phosphatidate phosphatase activity
MAG.T21.41_01082	176299.Atu3687	5.4e-46	192.2	Rhizobiaceae	viuA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	1NMCN@1224,2TW4E@28211,4BD5J@82115,COG4774@1,COG4774@2	NA|NA|NA	P	TonB-dependent Receptor Plug Domain
MAG.T21.41_01083	330214.NIDE3526	1.3e-32	146.4	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_01084	330214.NIDE3525	5.2e-59	235.0	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_01085	330214.NIDE2183	8.8e-65	254.2	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_01086	251221.35214547	1.5e-78	300.1	Cyanobacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1G3US@1117,COG4773@1,COG4773@2	NA|NA|NA	P	COGs COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid
MAG.T21.41_01087	287.DR97_5937	7.6e-107	394.0	Pseudomonas aeruginosa group													Bacteria	1MW2S@1224,1S0GC@1236,1YKQ2@136841,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_01088	596153.Alide_0098	2.4e-07	60.8	Comamonadaceae													Bacteria	1PUUR@1224,2AEYP@1,2W5RB@28216,314WM@2,4AIKP@80864	NA|NA|NA		
MAG.T21.41_01090	269796.Rru_A1438	6.1e-25	120.9	Rhodospirillales				ko:K03088					ko00000,ko03021				Bacteria	1N6SV@1224,2JZNG@204441,2UA5H@28211,COG1595@1,COG1595@2	NA|NA|NA	K	ECF sigma factor
MAG.T21.41_01091	438753.AZC_4432	1.2e-44	187.2	Xanthobacteraceae				ko:K07165					ko00000				Bacteria	1RA2H@1224,2U6IZ@28211,3EZPM@335928,COG3712@1,COG3712@2	NA|NA|NA	PT	Domain of unknown function (DUF4880)
MAG.T21.41_01094	330214.NIDE2084	1.4e-43	181.8	Nitrospirae													Bacteria	3J1BP@40117,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin domain
MAG.T21.41_01095	330214.NIDE2215	1.7e-92	345.9	Bacteria	hel	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	COG2503@1,COG2503@2	NA|NA|NA	M	HAD superfamily, subfamily IIIB (Acid phosphatase)
MAG.T21.41_01097	330214.NIDE2217	5.8e-176	624.0	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_01099	330214.NIDE2219	7.1e-276	956.1	Bacteria				ko:K06907					ko00000				Bacteria	COG3497@1,COG3497@2	NA|NA|NA	S	Phage tail sheath protein subtilisin-like domain
MAG.T21.41_01100	330214.NIDE2220	6.8e-95	353.2	Bacteria													Bacteria	2DB76@1,2Z7JZ@2	NA|NA|NA	S	phage tail region protein
MAG.T21.41_01101	330214.NIDE2221	6.8e-88	330.5	Bacteria													Bacteria	2AAD4@1,30ZP1@2	NA|NA|NA		
MAG.T21.41_01102	330214.NIDE2670	3.5e-156	557.8	Nitrospirae	cobB		6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120		R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000			iAF987.Gmet_0470	Bacteria	3J0HM@40117,COG1797@1,COG1797@2	NA|NA|NA	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
MAG.T21.41_01103	330214.NIDE2669	2.5e-101	374.8	Nitrospirae	cobO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008817,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019250,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K16092,ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.14.3		iAF1260.b1270,iB21_1397.B21_01256,iBWG_1329.BWG_1099,iECABU_c1320.ECABU_c15500,iECBD_1354.ECBD_2352,iECB_1328.ECB_01246,iECDH10B_1368.ECDH10B_1385,iECDH1ME8569_1439.ECDH1ME8569_1209,iECD_1391.ECD_01246,iECIAI1_1343.ECIAI1_1288,iECO111_1330.ECO111_1649,iECO26_1355.ECO26_1834,iETEC_1333.ETEC_1372,iEcDH1_1363.EcDH1_2379,iEcHS_1320.EcHS_A1379,iJO1366.b1270,iJR904.b1270,iLF82_1304.LF82_0253,iNRG857_1313.NRG857_06515,iUMNK88_1353.UMNK88_1599,iY75_1357.Y75_RS06640,iYL1228.KPN_01266,ic_1306.c1735	Bacteria	3J0NJ@40117,COG2109@1,COG2109@2	NA|NA|NA	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
MAG.T21.41_01104	330214.NIDE2666	5.4e-96	357.1	Bacteria	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.2.1.88,1.5.5.2,2.5.1.17	ko:K00798,ko:K13821	ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130	M00122	R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268	RC00080,RC00083,RC00216,RC00242,RC00255,RC00533	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	COG2096@1,COG2096@2	NA|NA|NA	S	cob(I)yrinic acid a,c-diamide adenosyltransferase activity
MAG.T21.41_01105	330214.NIDE2665	5.3e-69	267.3	Nitrospirae	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62,6.3.5.10	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R05225,R06558	RC00002,RC00010,RC00428,RC01302	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	Bacteria	3J0UG@40117,COG2087@1,COG2087@2	NA|NA|NA	H	Cobinamide kinase / cobinamide phosphate guanyltransferase
MAG.T21.41_01106	330214.NIDE2664	8.8e-158	563.1	Nitrospirae	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21,6.3.5.11,6.3.5.9	ko:K00768,ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	M00122	R04148,R05224,R05815	RC00010,RC00033,RC00063,RC01301	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169	Bacteria	3J0C9@40117,COG2038@1,COG2038@2	NA|NA|NA	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
MAG.T21.41_01107	330214.NIDE2663	6.9e-104	383.6	Nitrospirae	cobS	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0VC@40117,COG0368@1,COG0368@2	NA|NA|NA	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MAG.T21.41_01109	330214.NIDE2671	0.0	1159.4	Bacteria	btuB			ko:K02014,ko:K16092					ko00000,ko02000	1.B.14,1.B.14.3			Bacteria	COG4206@1,COG4206@2	NA|NA|NA	H	cobalamin-transporting ATPase activity
MAG.T21.41_01110	330214.NIDE2672	1.6e-152	545.4	Nitrospirae	hmuV		3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14			Bacteria	3J14U@40117,COG1120@1,COG1120@2	NA|NA|NA	HP	ABC transporter
MAG.T21.41_01111	330214.NIDE2673	9.6e-182	642.9	Nitrospirae				ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14			Bacteria	3J11Y@40117,COG0609@1,COG0609@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAG.T21.41_01112	330214.NIDE2674	1.6e-71	275.4	Nitrospirae				ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14			Bacteria	3J173@40117,COG0614@1,COG0614@2	NA|NA|NA	P	Periplasmic binding protein
MAG.T21.41_01114	886293.Sinac_0365	5.3e-147	527.7	Planctomycetes													Bacteria	2J0XM@203682,COG3385@1,COG3385@2	NA|NA|NA	L	transposase
MAG.T21.41_01115	575540.Isop_1415	9.5e-30	136.0	Planctomycetes	mutS			ko:K03555	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	2IY9B@203682,COG0249@1,COG0249@2	NA|NA|NA	L	Mismatch repair ATPase (MutS family)
MAG.T21.41_01117	330214.NIDE1932	4e-293	1013.4	Nitrospirae	fdsA		1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0UR@40117,COG3383@1,COG3383@2	NA|NA|NA	C	Molydopterin dinucleotide binding domain
MAG.T21.41_01118	330214.NIDE1933	9e-121	439.9	Bacteria	focA			ko:K02598,ko:K06212,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3			Bacteria	COG2116@1,COG2116@2	NA|NA|NA	P	formate transmembrane transporter activity
MAG.T21.41_01120	330214.NIDE1934	2.1e-206	724.9	Nitrospirae	ampG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600		ko:K08218	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.25			Bacteria	3J0ZP@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Acetyl-coenzyme A transporter 1
MAG.T21.41_01121	1166018.FAES_0893	2.7e-55	223.4	Cytophagia													Bacteria	28IG1@1,2Z8HJ@2,47NG6@768503,4NK1S@976	NA|NA|NA		
MAG.T21.41_01127	1267535.KB906767_gene1580	2.4e-14	85.9	Bacteria	MA20_17390			ko:K00713,ko:K06338					ko00000,ko01000,ko01003,ko01005				Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01129	1267535.KB906767_gene732	2.1e-34	151.8	Bacteria													Bacteria	COG1873@1,COG1873@2	NA|NA|NA	S	PRC-barrel domain
MAG.T21.41_01130	909663.KI867151_gene3005	5.1e-264	917.5	Syntrophobacterales	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000		GH13,GH77		Bacteria	1QTVK@1224,2MQXA@213462,2WJX1@28221,42MEW@68525,COG3280@1,COG3280@2	NA|NA|NA	G	PFAM alpha amylase, catalytic
MAG.T21.41_01131	1163617.SCD_n02431	9.7e-111	407.1	Betaproteobacteria	glgC		2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2768	Bacteria	1MVTC@1224,2VIP2@28216,COG0448@1,COG0448@2	NA|NA|NA	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAG.T21.41_01132	76114.ebA5105	7.6e-150	537.0	Rhodocyclales	cccA												Bacteria	1N4E1@1224,2KYC1@206389,2VNWX@28216,COG1858@1,COG1858@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01133	1121441.AUCX01000006_gene1016	4.1e-25	121.3	Proteobacteria													Bacteria	1RJK4@1224,2BQVQ@1,32JSN@2	NA|NA|NA	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase
MAG.T21.41_01134	395019.Bmul_5667	1.5e-40	172.6	Burkholderiaceae													Bacteria	1KECK@119060,1PITZ@1224,2BU42@1,2W7D7@28216,32PCX@2	NA|NA|NA	S	Domain of unknown function (DUF2703)
MAG.T21.41_01135	1122137.AQXF01000005_gene1077	8.2e-24	116.7	Alphaproteobacteria													Bacteria	1N6S5@1224,2UG0P@28211,COG3791@1,COG3791@2	NA|NA|NA	S	Glutathione-dependent formaldehyde-activating
MAG.T21.41_01136	1040989.AWZU01000010_gene4218	9.6e-10	69.3	Bradyrhizobiaceae													Bacteria	1N3IU@1224,2EHU7@1,2UZRQ@28211,33BJV@2,3K0TC@41294	NA|NA|NA		
MAG.T21.41_01137	1502724.FF80_03329	1.2e-07	63.5	Alphaproteobacteria													Bacteria	1NE9B@1224,2DQAW@1,2UGZ4@28211,335Q1@2	NA|NA|NA	S	genomic island protein Bartonella henselae str. Houston-1 gi 49238509 emb CAF27741.1 and to
MAG.T21.41_01138	880072.Desac_1327	7.4e-115	421.0	Syntrophobacterales													Bacteria	1MV6W@1224,2MRYR@213462,2WJWT@28221,42MZY@68525,COG1086@1,COG1086@2,COG2148@1,COG2148@2	NA|NA|NA	M	Undecaprenyl-phosphate galactose phosphotransferase
MAG.T21.41_01139	330214.NIDE2410	0.0	1144.0	Nitrospirae				ko:K02030		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	3J0WC@40117,COG0673@1,COG0673@2,COG1063@1,COG1063@2	NA|NA|NA	C	Oxidoreductase family, NAD-binding Rossmann fold
MAG.T21.41_01140	330214.NIDE2411	2.2e-212	745.0	Bacteria	exeA			ko:K02450		M00331			ko00000,ko00002,ko02044	9.B.42			Bacteria	COG0457@1,COG0457@2,COG3267@1,COG3267@2	NA|NA|NA	S	peptidyl-tyrosine sulfation
MAG.T21.41_01141	330214.NIDE2426	2e-33	149.4	Nitrospirae													Bacteria	3J0JU@40117,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T21.41_01142	330214.NIDE2413	7.9e-61	240.7	Bacteria	sixA-2			ko:K08296					ko00000,ko01000				Bacteria	COG5607@1,COG5607@2	NA|NA|NA	F	PFAM CHAD domain containing protein
MAG.T21.41_01143	330214.NIDE2414	1.3e-58	232.6	Bacteria	sixA			ko:K08296					ko00000,ko01000				Bacteria	COG2062@1,COG2062@2	NA|NA|NA	T	phosphohistidine phosphatase, SixA
MAG.T21.41_01144	330214.NIDE2415	1.4e-252	878.6	Nitrospirae	ppx		3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000,ko02048				Bacteria	3J0K5@40117,COG0248@1,COG0248@2,COG2206@1,COG2206@2	NA|NA|NA	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01145	330214.NIDE2416	1.6e-112	412.1	Nitrospirae	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0060255,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186		ko:K02039					ko00000				Bacteria	3J0M6@40117,COG0704@1,COG0704@2	NA|NA|NA	P	Plays a role in the regulation of phosphate uptake
MAG.T21.41_01146	330214.NIDE2417	5e-135	487.3	Nitrospirae	pstB		3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Bacteria	3J0EU@40117,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MAG.T21.41_01147	330214.NIDE2418	6.9e-242	843.2	Nitrospirae	pstA			ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	3J0SE@40117,COG0581@1,COG0581@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T21.41_01148	330214.NIDE2419	0.0	1177.5	Bacteria	pstC			ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	COG4590@1,COG4590@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T21.41_01151	330214.NIDE3148	2.6e-160	571.6	Bacteria	modC		2.10.1.1,3.6.3.29,3.6.3.55	ko:K02017,ko:K02018,ko:K03750,ko:K15497	ko00790,ko01100,ko02010,map00790,map01100,map02010	M00189,M00423	R09735,R10531	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8			Bacteria	COG3842@1,COG3842@2	NA|NA|NA	P	ATPase activity
MAG.T21.41_01152	330214.NIDE3149	4.8e-109	400.6	Bacteria	modB			ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423			ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8			Bacteria	COG4149@1,COG4149@2	NA|NA|NA	P	molybdate abc transporter
MAG.T21.41_01154	330214.NIDE3152	4.6e-108	397.5	Nitrospirae	modA			ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	3J18Z@40117,COG0725@1,COG0725@2	NA|NA|NA	P	Bacterial extracellular solute-binding protein
MAG.T21.41_01155	330214.NIDE3153	1e-235	822.8	Bacteria													Bacteria	COG3746@1,COG3746@2	NA|NA|NA		
MAG.T21.41_01156	671143.DAMO_2734	5.8e-19	100.1	Bacteria	cas2			ko:K09951					ko00000,ko02048				Bacteria	COG1343@1,COG1343@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MAG.T21.41_01157	671143.DAMO_2735	2.1e-201	708.8	unclassified Bacteria	cas1	GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0030145,GO:0034641,GO:0034655,GO:0035312,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045145,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	3.1.12.1	ko:K07464,ko:K15342					ko00000,ko01000,ko02048,ko03400				Bacteria	2NPPQ@2323,COG1468@1,COG1468@2,COG1518@1,COG1518@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MAG.T21.41_01158	671143.DAMO_1792	1.1e-48	199.9	Bacteria													Bacteria	COG4636@1,COG4636@2	NA|NA|NA	D	protein conserved in cyanobacteria
MAG.T21.41_01159	330214.NIDE1553	3.1e-22	110.9	Bacteria													Bacteria	2ECNM@1,336KG@2	NA|NA|NA		
MAG.T21.41_01160	243231.GSU0054	1.1e-172	613.2	Proteobacteria				ko:K19132					ko00000,ko02048				Bacteria	1RD13@1224,2DBHK@1,2Z9AT@2	NA|NA|NA	S	CRISPR-associated protein, GSU0054 family (Cas_GSU0054)
MAG.T21.41_01161	243231.GSU0053	2.1e-130	472.2	Deltaproteobacteria	csb1			ko:K19131					ko00000,ko02048				Bacteria	1RBTZ@1224,28KC2@1,2WT79@28221,2Z9Z2@2,42XV5@68525	NA|NA|NA	S	CRISPR-associated protein GSU0053 (Cas_GSU0053)
MAG.T21.41_01162	1123242.JH636435_gene1722	1e-36	160.6	Planctomycetes	cas3			ko:K07012					ko00000,ko01000,ko02048				Bacteria	2IXEG@203682,COG1203@1,COG1203@2	NA|NA|NA	L	CRISPR-associated helicase, Cas3
MAG.T21.41_01163	243231.GSU0051	3.3e-297	1027.7	Deltaproteobacteria	cas3			ko:K07012					ko00000,ko01000,ko02048				Bacteria	1R8FD@1224,2WMHK@28221,42NNV@68525,COG1203@1,COG1203@2	NA|NA|NA	L	TIGRFAM CRISPR-associated helicase Cas3
MAG.T21.41_01166	330214.NIDE2500	1.1e-14	85.1	Bacteria				ko:K07171					ko00000,ko01000,ko02048				Bacteria	COG2337@1,COG2337@2	NA|NA|NA	T	Toxic component of a toxin-antitoxin (TA) module
MAG.T21.41_01167	330214.NIDE2499	5.7e-26	122.9	Bacteria													Bacteria	2EQJE@1,33I5F@2	NA|NA|NA	S	Protein of unknown function (DUF2281)
MAG.T21.41_01168	330214.NIDE1537	2.6e-134	485.0	Bacteria				ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	COG4249@1,COG4249@2	NA|NA|NA	S	B-1 B cell differentiation
MAG.T21.41_01171	330214.NIDE1532	4.9e-128	464.2	Bacteria	folB		1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8	ko:K01091,ko:K01633,ko:K15429	ko00630,ko00790,ko01100,ko01110,ko01130,map00630,map00790,map01100,map01110,map01130	M00126,M00840	R00597,R01334,R03504,R11037,R11073	RC00003,RC00017,RC00334,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	COG1539@1,COG1539@2,COG2520@1,COG2520@2	NA|NA|NA	J	tRNA (guanine(37)-N(1))-methyltransferase activity
MAG.T21.41_01172	330214.NIDE1531	3.4e-144	517.7	Bacteria	trpH		3.1.3.97,4.1.2.13	ko:K01624,ko:K07053	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R00188,R01068,R01070,R01829,R02568,R11188	RC00078,RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0613@1,COG0613@2	NA|NA|NA	Q	PHP domain protein
MAG.T21.41_01173	1122604.JONR01000001_gene1979	6.2e-82	311.6	Xanthomonadales			2.7.11.1	ko:K12132					ko00000,ko01000,ko01001				Bacteria	1MV1P@1224,1RR36@1236,1X6T3@135614,COG0515@1,COG0515@2,COG4252@1,COG4252@2	NA|NA|NA	KLT	Protein tyrosine kinase
MAG.T21.41_01174	330214.NIDE1529	1.6e-101	375.9	Bacteria			3.1.3.16	ko:K01090,ko:K20074					ko00000,ko01000,ko01009				Bacteria	COG0631@1,COG0631@2	NA|NA|NA	T	protein serine/threonine phosphatase activity
MAG.T21.41_01175	330214.NIDE1528	8.7e-72	276.9	Bacteria													Bacteria	COG1716@1,COG1716@2	NA|NA|NA	T	histone H2A K63-linked ubiquitination
MAG.T21.41_01176	330214.NIDE1527	3.3e-48	198.4	Bacteria				ko:K18491	ko04550,map04550				ko00000,ko00001,ko03000				Bacteria	COG3266@1,COG3266@2	NA|NA|NA	GM	domain, Protein
MAG.T21.41_01178	330214.NIDE1525	8.2e-67	259.6	Nitrospirae													Bacteria	3J1CB@40117,COG0432@1,COG0432@2	NA|NA|NA	S	Uncharacterised protein family UPF0047
MAG.T21.41_01180	330214.NIDE1522	6.6e-109	400.2	Nitrospirae	yieH		3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	3J15X@40117,COG0637@1,COG0637@2	NA|NA|NA	S	Haloacid dehalogenase-like hydrolase
MAG.T21.41_01181	330214.NIDE1521	4.7e-123	447.6	Bacteria				ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14			Bacteria	COG0614@1,COG0614@2	NA|NA|NA	P	abc-type fe3 -hydroxamate transport system, periplasmic component
MAG.T21.41_01182	330214.NIDE1520	1.3e-149	535.8	Nitrospirae	crtB		2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	3J17J@40117,COG1562@1,COG1562@2	NA|NA|NA	I	Squalene/phytoene synthase
MAG.T21.41_01183	330214.NIDE1519	3.4e-191	674.5	Nitrospirae			1.3.5.5	ko:K02293	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04786,R04787,R07510,R09652,R09653,R09654	RC01214,RC01958,RC03092,RC03093	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1ES@40117,COG1232@1,COG1232@2	NA|NA|NA	C	Flavin containing amine oxidoreductase
MAG.T21.41_01184	330214.NIDE1518	6.3e-101	373.6	Nitrospirae			3.2.2.27	ko:K21929	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0MR@40117,COG1573@1,COG1573@2	NA|NA|NA	L	Uracil DNA glycosylase superfamily
MAG.T21.41_01186	330214.NIDE1515	6.7e-235	819.7	Nitrospirae	pmbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03592					ko00000,ko01002				Bacteria	3J0P7@40117,COG0312@1,COG0312@2	NA|NA|NA	S	Putative modulator of DNA gyrase
MAG.T21.41_01187	330214.NIDE1514	2.8e-70	271.2	Nitrospirae	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03568					ko00000,ko01002				Bacteria	3J0F9@40117,COG0312@1,COG0312@2	NA|NA|NA	S	Putative modulator of DNA gyrase
MAG.T21.41_01189	1280944.HY17_08070	6.2e-108	397.1	Hyphomonadaceae	ftrB			ko:K01420,ko:K13642,ko:K21563					ko00000,ko03000				Bacteria	1R5P7@1224,2TV0F@28211,43XUV@69657,COG0664@1,COG0664@2	NA|NA|NA	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MAG.T21.41_01190	1280944.HY17_08075	6.6e-62	243.4	Hyphomonadaceae	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016830,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0061798,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394	RC03420	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2571,ic_1306.c0862	Bacteria	1MW3W@1224,2TQQP@28211,43ZGX@69657,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAG.T21.41_01192	1121033.AUCF01000028_gene377	2.1e-21	110.2	Rhodospirillales	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU63@1224,2JQVG@204441,2TQPZ@28211,COG0265@1,COG0265@2	NA|NA|NA	O	Belongs to the peptidase S1C family
MAG.T21.41_01193	543913.D521_1470	5.6e-09	67.8	Betaproteobacteria													Bacteria	1RH59@1224,2E8C5@1,2W4XB@28216,332QT@2	NA|NA|NA		
MAG.T21.41_01194	330214.NIDE1646	4.5e-16	91.7	Bacteria													Bacteria	2EUFJ@1,33MXU@2	NA|NA|NA		
MAG.T21.41_01195	330214.NIDE1510	3.6e-146	524.2	Nitrospirae	rseP		3.4.21.107	ko:K04771,ko:K11749	ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0GI@40117,COG0750@1,COG0750@2	NA|NA|NA	M	Peptidase family M50
MAG.T21.41_01196	330214.NIDE1509	5.2e-282	976.5	Nitrospirae	proS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iJN678.proS,iUTI89_1310.UTI89_C0210	Bacteria	3J0EY@40117,COG0442@1,COG0442@2	NA|NA|NA	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MAG.T21.41_01199	1400524.KL370779_gene629	1.9e-39	169.1	Bacteria													Bacteria	COG0022@1,COG0022@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAG.T21.41_01200	314607.KB13_1186	9.7e-137	493.8	unclassified Betaproteobacteria			1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110		R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000				Bacteria	1KR2H@119066,1MWR0@1224,2WB72@28216,COG1032@1,COG1032@2	NA|NA|NA	C	B12 binding domain
MAG.T21.41_01201	1430440.MGMSRv2_4197	1.7e-31	143.7	Bacteria													Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T21.41_01202	290397.Adeh_3056	2.1e-12	80.1	delta/epsilon subdivisions			2.4.1.152,2.4.1.65	ko:K20151					ko00000,ko01000,ko01003		GT10		Bacteria	1NKGF@1224,28IN0@1,2Z8NG@2,43051@68525	NA|NA|NA	H	Glycosyltransferase family 10 (fucosyltransferase) C-term
MAG.T21.41_01203	710696.Intca_2645	2.4e-10	72.4	Intrasporangiaceae													Bacteria	2GKI5@201174,4FI7P@85021,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase family
MAG.T21.41_01209	330214.NIDE1733	1e-18	99.0	Nitrospirae	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Bacteria	3J0B9@40117,COG0525@1,COG0525@2	NA|NA|NA	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MAG.T21.41_01210	330214.NIDE1732	7.3e-121	440.3	Nitrospirae	modD		2.4.2.19	ko:K00767,ko:K03813	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0JY@40117,COG0157@1,COG0157@2	NA|NA|NA	H	Quinolinate phosphoribosyl transferase, C-terminal domain
MAG.T21.41_01211	330214.NIDE1731	6e-109	400.6	Nitrospirae	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	2.7.1.33,6.3.4.15	ko:K01947,ko:K03524	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	3J0U2@40117,COG0340@1,COG0340@2	NA|NA|NA	H	Biotin/lipoate A/B protein ligase family
MAG.T21.41_01212	330214.NIDE1730	4.5e-127	460.7	Nitrospirae	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1986	Bacteria	3J0TR@40117,COG1521@1,COG1521@2	NA|NA|NA	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MAG.T21.41_01213	330214.NIDE1729	3.1e-69	268.1	Nitrospirae	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363		ko:K03687					ko00000,ko03029,ko03110				Bacteria	3J0QP@40117,COG0576@1,COG0576@2	NA|NA|NA	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MAG.T21.41_01214	1316936.K678_08032	4.6e-86	324.7	Rhodospirillales													Bacteria	1MX0S@1224,2DBJ8@1,2JWUE@204441,2TT7Z@28211,2Z9JM@2	NA|NA|NA	S	NAD-specific glutamate dehydrogenase
MAG.T21.41_01216	1540091.A0A0A0RNF3_9CAUD	2.9e-23	115.2	Myoviridae													Viruses	4QBHW@10239,4QJZQ@10662,4QTT7@28883	NA|NA|NA	S	sequence-specific DNA binding transcription factor activity
MAG.T21.41_01219	566466.NOR53_835	2.7e-14	85.9	unclassified Gammaproteobacteria	rpoS	GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03087	ko02026,ko05111,map02026,map05111				ko00000,ko00001,ko03021				Bacteria	1J8SJ@118884,1MUDI@1224,1RN8V@1236,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma-70 factor, region 1.2
MAG.T21.41_01222	330214.NIDE2279	4.6e-41	175.6	Bacteria													Bacteria	COG0582@1,COG0582@2	NA|NA|NA	L	DNA integration
MAG.T21.41_01223	237368.SCABRO_00363	5e-141	507.7	Planctomycetes													Bacteria	2J1MI@203682,COG3177@1,COG3177@2	NA|NA|NA	S	Fic/DOC family
MAG.T21.41_01224	316055.RPE_2627	1.5e-11	75.1	Alphaproteobacteria													Bacteria	1NH1S@1224,2UJ09@28211,COG2442@1,COG2442@2	NA|NA|NA	S	Protein of unknown function (DUF433)
MAG.T21.41_01225	118168.MC7420_8133	1.1e-240	839.3	Oscillatoriales				ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922				ko00000,ko00001				Bacteria	1G3VS@1117,1H860@1150,COG3387@1,COG3387@2	NA|NA|NA	G	Glycosyl hydrolases family 15
MAG.T21.41_01226	330214.NIDE0186	4.2e-200	704.1	Bacteria													Bacteria	COG2124@1,COG2124@2	NA|NA|NA	Q	cytochrome p450
MAG.T21.41_01228	330214.NIDE1804	0.0	1384.8	Nitrospirae	czcA			ko:K15726					ko00000,ko02000	2.A.6.1.2			Bacteria	3J0ZR@40117,COG3696@1,COG3696@2	NA|NA|NA	P	AcrB/AcrD/AcrF family
MAG.T21.41_01229	330214.NIDE3502	8.8e-163	580.1	Bacteria													Bacteria	COG3387@1,COG3387@2	NA|NA|NA	G	glucan 1,4-alpha-glucosidase activity
MAG.T21.41_01230	330214.NIDE1422	4.6e-124	450.7	Nitrospirae	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.3.1.128,6.3.5.2	ko:K01951,ko:K03790	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002,ko03009			iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	Bacteria	3J0A2@40117,COG0518@1,COG0518@2,COG0519@1,COG0519@2	NA|NA|NA	F	Catalyzes the synthesis of GMP from XMP
MAG.T21.41_01231	330214.NIDE1423	4.6e-137	494.6	Nitrospirae	rsuA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.20,5.4.99.22	ko:K06178,ko:K06181,ko:K06183,ko:K07058					ko00000,ko01000,ko03009				Bacteria	3J0RN@40117,COG1187@1,COG1187@2	NA|NA|NA	J	Belongs to the pseudouridine synthase RsuA family
MAG.T21.41_01232	330214.NIDE1425	6.3e-116	423.7	Nitrospirae	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iJN678.aspS,iSFV_1184.SFV_1868	Bacteria	3J0FR@40117,COG0173@1,COG0173@2	NA|NA|NA	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAG.T21.41_01233	1122951.ATUE01000006_gene971	1.6e-07	62.8	Gammaproteobacteria	cpaF			ko:K02283					ko00000,ko02035,ko02044				Bacteria	1QTTS@1224,1RQI5@1236,COG4962@1,COG4962@2	NA|NA|NA	U	PFAM CopG domain protein DNA-binding domain protein
MAG.T21.41_01234	1280954.HPO_04830	2.5e-67	262.3	Hyphomonadaceae	traG			ko:K03205	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1MV1G@1224,2TR6N@28211,43WTX@69657,COG3505@1,COG3505@2	NA|NA|NA	U	COG3505 Type IV secretory pathway, VirD4 components
MAG.T21.41_01235	979556.MTES_0844	6.5e-51	206.5	Microbacteriaceae	wbaP		2.7.8.6	ko:K00996					ko00000,ko01000,ko01005				Bacteria	2GK0M@201174,4FK4B@85023,COG1086@1,COG1086@2,COG2148@1,COG2148@2	NA|NA|NA	M	Bacterial sugar transferase
MAG.T21.41_01236	164757.Mjls_1347	2.2e-74	286.2	Mycobacteriaceae													Bacteria	23DDK@1762,2IN90@201174,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferase 4-like domain
MAG.T21.41_01237	446471.Xcel_2903	2.9e-116	425.2	Promicromonosporaceae			2.4.1.349	ko:K00786,ko:K12994					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	2GK9J@201174,4F4ZZ@85017,COG0438@1,COG0438@2	NA|NA|NA	M	PFAM Glycosyl transferase, group 1
MAG.T21.41_01238	1089551.KE386572_gene862	1.8e-121	442.6	Alphaproteobacteria													Bacteria	1RBSV@1224,28YQ6@1,2UQYQ@28211,2ZKHR@2	NA|NA|NA		
MAG.T21.41_01239	1089551.KE386572_gene863	2.2e-33	148.7	Proteobacteria													Bacteria	1N678@1224,COG1396@1,COG1396@2	NA|NA|NA	K	PFAM helix-turn-helix domain protein
MAG.T21.41_01240	1101192.KB910516_gene1103	1.7e-43	182.6	Methylobacteriaceae	spoT		2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230		R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009				Bacteria	1JT3M@119045,1RGUA@1224,2U05J@28211,COG0317@1,COG0317@2	NA|NA|NA	KT	HD domain
MAG.T21.41_01241	1122970.AUHC01000002_gene1395	4.8e-54	217.6	Sphingomonadales			3.2.2.24	ko:K05521					ko00000,ko01000				Bacteria	1NTUR@1224,2K2FA@204457,2U0DV@28211,COG1397@1,COG1397@2,COG2453@1,COG2453@2	NA|NA|NA	OT	ADP-ribosylglycohydrolase
MAG.T21.41_01242	1122970.AUHC01000002_gene1395	2e-89	335.9	Sphingomonadales			3.2.2.24	ko:K05521					ko00000,ko01000				Bacteria	1NTUR@1224,2K2FA@204457,2U0DV@28211,COG1397@1,COG1397@2,COG2453@1,COG2453@2	NA|NA|NA	OT	ADP-ribosylglycohydrolase
MAG.T21.41_01243	765912.Thimo_2233	5.2e-60	237.7	Chromatiales	nudF1		3.6.1.55	ko:K03574					ko00000,ko01000,ko03400				Bacteria	1MXHA@1224,1T1QN@1236,1WYUW@135613,COG1051@1,COG1051@2,COG4111@1,COG4111@2	NA|NA|NA	F	NUDIX domain
MAG.T21.41_01246	330214.NIDE0557	4.6e-82	312.8	Bacteria													Bacteria	COG0642@1,COG0745@1,COG0745@2,COG2203@1,COG2203@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_01247	330214.NIDE0544	1.9e-127	462.2	Bacteria				ko:K01989		M00247			ko00000,ko00002,ko02000				Bacteria	COG2984@1,COG2984@2	NA|NA|NA	S	ABC transporter substrate binding protein
MAG.T21.41_01248	330214.NIDE0545	0.0	1656.0	Bacteria			3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	COG0745@1,COG0745@2,COG2202@1,COG2202@2,COG3290@1,COG3290@2	NA|NA|NA	T	protein histidine kinase activity
MAG.T21.41_01249	330214.NIDE0546	2.5e-225	788.5	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG4771@2	NA|NA|NA	P	transport
MAG.T21.41_01250	330214.NIDE0547	0.0	1206.8	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG4771@2	NA|NA|NA	P	transport
MAG.T21.41_01253	330214.NIDE0556	9e-227	792.7	Bacteria	fadL			ko:K06076					ko00000,ko02000	1.B.9			Bacteria	COG2067@1,COG2067@2	NA|NA|NA	I	long-chain fatty acid transporting porin activity
MAG.T21.41_01254	330214.NIDE0557	0.0	1511.9	Bacteria													Bacteria	COG0642@1,COG0745@1,COG0745@2,COG2203@1,COG2203@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_01255	330214.NIDE0558	2.5e-245	854.7	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01257	330214.NIDE0561	4.2e-272	943.3	Nitrospirae													Bacteria	3J10V@40117,COG0535@1,COG0535@2	NA|NA|NA	C	Iron-sulfur cluster-binding domain
MAG.T21.41_01258	330214.NIDE0562	0.0	1314.3	Bacteria	usp1		1.6.3.4	ko:K22405					ko00000,ko01000				Bacteria	COG0589@1,COG0589@2,COG1592@1,COG1592@2	NA|NA|NA	C	Rubrerythrin
MAG.T21.41_01259	330214.NIDE0563	6.5e-301	1039.3	Nitrospirae													Bacteria	3J0WM@40117,COG1032@1,COG1032@2	NA|NA|NA	C	Elongator protein 3, MiaB family, Radical SAM
MAG.T21.41_01260	330214.NIDE0564	7.7e-123	446.4	Nitrospirae	ubiE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0040007,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000			iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Bacteria	3J0S6@40117,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MAG.T21.41_01261	330214.NIDE0565	6.1e-140	503.4	Nitrospirae													Bacteria	3J0J9@40117,COG0426@1,COG0426@2	NA|NA|NA	C	Metallo-beta-lactamase superfamily
MAG.T21.41_01263	330214.NIDE0568	0.0	1588.5	Nitrospirae	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03701	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	3J0C7@40117,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MAG.T21.41_01265	330214.NIDE0571	1.4e-53	215.3	Bacteria				ko:K09922					ko00000				Bacteria	COG3169@1,COG3169@2	NA|NA|NA	S	Protein conserved in bacteria
MAG.T21.41_01269	330214.NIDE0577	0.0	1291.6	Bacteria													Bacteria	COG0433@1,COG0433@2	NA|NA|NA	S	helicase activity
MAG.T21.41_01270	330214.NIDE0578	0.0	1596.3	Bacteria	exsG		3.1.3.3,3.1.4.17	ko:K01120,ko:K07315	ko00230,map00230		R00191,R01234	RC00296	ko00000,ko00001,ko01000,ko03021				Bacteria	COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG3290@1,COG3290@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2	NA|NA|NA	T	protein histidine kinase activity
MAG.T21.41_01271	330214.NIDE0579	3.5e-101	374.4	Nitrospirae				ko:K02282					ko00000,ko02035,ko02044				Bacteria	3J12Q@40117,COG2197@1,COG2197@2	NA|NA|NA	K	Product type r regulator
MAG.T21.41_01272	330214.NIDE0580	4.6e-107	394.0	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_01273	330214.NIDE0581	2.1e-53	214.9	Bacteria	lpxC		3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_01274	330214.NIDE0582	0.0	2032.7	Bacteria			2.3.1.59,2.3.1.82	ko:K14658,ko:K17840,ko:K18815		M00664			br01600,ko00000,ko00002,ko01000,ko01504				Bacteria	COG1752@1,COG1752@2,COG3153@1,COG3153@2	NA|NA|NA	S	transferase activity, transferring acyl groups
MAG.T21.41_01275	330214.NIDE0583	3.4e-84	317.8	Bacteria	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03535					ko00000,ko02000	2.A.1.14.1			Bacteria	COG2862@1,COG2862@2	NA|NA|NA	S	Uncharacterized protein family, UPF0114
MAG.T21.41_01276	330214.NIDE0584	0.0	1503.0	Nitrospirae													Bacteria	3J0ZF@40117,COG0642@1,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_01277	330214.NIDE0585	2.6e-212	745.3	Nitrospirae													Bacteria	3J0ZF@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG5002@1,COG5002@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01278	330214.NIDE1024	7.6e-71	273.9	Bacteria													Bacteria	COG2206@1,COG2206@2	NA|NA|NA	T	PFAM metal-dependent phosphohydrolase, HD sub domain
MAG.T21.41_01279	247490.KSU1_D0875	3.7e-11	75.1	Planctomycetes													Bacteria	2A5QB@1,2J3IC@203682,30UF7@2	NA|NA|NA		
MAG.T21.41_01280	330214.NIDE1026	2.5e-113	414.8	Bacteria	nosR			ko:K19339,ko:K19343					ko00000,ko03000				Bacteria	COG3901@1,COG3901@2	NA|NA|NA	CK	FMN binding
MAG.T21.41_01282	330214.NIDE1028	2.7e-266	924.1	Bacteria				ko:K12065					ko00000,ko02044	3.A.7.11.1			Bacteria	COG2433@1,COG2433@2	NA|NA|NA		
MAG.T21.41_01283	330214.NIDE1022	1.9e-70	271.9	Bacteria	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	COG2193@1,COG2193@2	NA|NA|NA	P	ferroxidase activity
MAG.T21.41_01284	330214.NIDE1021	3.6e-79	300.8	Bacteria	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	COG2193@1,COG2193@2	NA|NA|NA	P	ferroxidase activity
MAG.T21.41_01285	330214.NIDE1020	0.0	1458.7	Nitrospirae	topA		5.99.1.2	ko:K03168,ko:K07479					ko00000,ko01000,ko03032,ko03400				Bacteria	3J0DN@40117,COG0550@1,COG0550@2,COG0551@1,COG0551@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAG.T21.41_01286	330214.NIDE1019	1.4e-156	559.3	Nitrospirae	dprA		5.99.1.2	ko:K03168,ko:K04096					ko00000,ko01000,ko03032,ko03400				Bacteria	3J0Q8@40117,COG0758@1,COG0758@2	NA|NA|NA	L	DNA recombination-mediator protein A
MAG.T21.41_01287	330214.NIDE1018	5.1e-276	956.4	Nitrospirae	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360		ko:K08301					ko00000,ko01000,ko03009,ko03019				Bacteria	3J0DK@40117,COG1530@1,COG1530@2	NA|NA|NA	J	Ribonuclease E/G family
MAG.T21.41_01288	330214.NIDE1017	3.3e-195	687.6	Nitrospirae	mrdB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K05837					ko00000,ko03036				Bacteria	3J0IA@40117,COG0772@1,COG0772@2	NA|NA|NA	D	Peptidoglycan polymerase that is essential for cell wall elongation
MAG.T21.41_01289	330214.NIDE1016	0.0	1098.2	Nitrospirae	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501				ko00000,ko00001,ko01000,ko01011			iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	Bacteria	3J0FY@40117,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin-binding Protein dimerisation domain
MAG.T21.41_01290	1121422.AUMW01000007_gene3173	5.9e-11	74.3	Peptococcaceae	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K03571					ko00000,ko03036	9.B.157.1			Bacteria	1V1EJ@1239,24RP5@186801,262R9@186807,COG2891@1,COG2891@2	NA|NA|NA	M	shape-determining protein MreD
MAG.T21.41_01291	330214.NIDE1014	1.5e-147	528.9	Nitrospirae	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963		ko:K03570					ko00000,ko03036	9.B.157.1			Bacteria	3J0S3@40117,COG1792@1,COG1792@2	NA|NA|NA	M	shape-determining protein MreC
MAG.T21.41_01292	330214.NIDE1013	6.2e-188	663.3	Nitrospirae	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944		ko:K03569					ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1			Bacteria	3J0BS@40117,COG1077@1,COG1077@2	NA|NA|NA	D	Actin
MAG.T21.41_01293	330214.NIDE1012	3.9e-85	320.9	Nitrospirae													Bacteria	3J0U3@40117,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T21.41_01294	330214.NIDE1011	1.5e-116	425.6	Nitrospirae	ppiD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552	5.2.1.8	ko:K01802,ko:K03769,ko:K03770					ko00000,ko01000,ko03110				Bacteria	3J1BR@40117,COG0760@1,COG0760@2	NA|NA|NA	O	SurA N-terminal domain
MAG.T21.41_01295	330214.NIDE1010	1.1e-155	556.2	Nitrospirae	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29,2.4.99.17	ko:K00773,ko:K07568			R03789,R10209	RC00063	ko00000,ko01000,ko03016				Bacteria	3J0HB@40117,COG0809@1,COG0809@2	NA|NA|NA	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MAG.T21.41_01296	330214.NIDE1009	2.7e-184	651.4	Nitrospirae	lytB	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K06381					ko00000				Bacteria	3J15K@40117,COG2385@1,COG2385@2	NA|NA|NA	D	Stage II sporulation protein
MAG.T21.41_01297	330214.NIDE1008	6.4e-30	136.3	Nitrospirae	yrzS												Bacteria	2DNS1@1,32YVX@2,3J1CZ@40117	NA|NA|NA	S	Protein of unknown function (DUF2905)
MAG.T21.41_01298	330214.NIDE1007	2.8e-170	604.7	Nitrospirae	asd	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0BR@40117,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MAG.T21.41_01299	59196.RICGR_0448	7.1e-18	97.4	Gammaproteobacteria													Bacteria	1N9I2@1224,1SZY8@1236,COG1598@1,COG1598@2	NA|NA|NA	S	HicB_like antitoxin of bacterial toxin-antitoxin system
MAG.T21.41_01302	1114964.L485_16425	1.8e-42	179.1	Sphingomonadales													Bacteria	1N19W@1224,2KDA7@204457,2UD6N@28211,COG0791@1,COG0791@2	NA|NA|NA	M	NLP P60 protein
MAG.T21.41_01305	670307.HYPDE_38818	1.1e-06	62.4	Hyphomicrobiaceae													Bacteria	1QVNY@1224,28JTG@1,2U7ED@28211,2Z7PY@2,3N6VP@45401	NA|NA|NA	S	Protein of unknown function (DUF2793)
MAG.T21.41_01306	1125863.JAFN01000001_gene3562	1.9e-29	137.5	Deltaproteobacteria	AAG												Bacteria	1MXXZ@1224,2WIU9@28221,42QDD@68525,COG4733@1,COG4733@2	NA|NA|NA	U	Phage-related protein, tail
MAG.T21.41_01307	1121456.ATVA01000019_gene1287	1.5e-119	436.4	Desulfovibrionales	wbpD		2.3.1.201	ko:K13018	ko00520,map00520		R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005				Bacteria	1MZV9@1224,2MG42@213115,2WNXR@28221,42PR0@68525,COG0110@1,COG0110@2,COG0673@1,COG0673@2	NA|NA|NA	S	Hexapeptide repeat of succinyl-transferase
MAG.T21.41_01308	330214.NIDE0878	1.9e-123	449.5	Bacteria				ko:K03980					ko00000,ko01011,ko02000	2.A.66.4			Bacteria	COG0728@1,COG0728@2	NA|NA|NA	M	peptidoglycan biosynthetic process
MAG.T21.41_01309	314285.KT71_09902	1.1e-83	317.8	unclassified Gammaproteobacteria	asnB		6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	1J58Y@118884,1MW4E@1224,1RQ7D@1236,COG0367@1,COG0367@2	NA|NA|NA	F	Asparagine synthase
MAG.T21.41_01310	330214.NIDE0879	1.7e-117	429.5	Bacteria													Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_01311	330214.NIDE0880	2.8e-100	372.1	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01313	330214.NIDE0883	5.1e-174	617.1	Bacteria	exoA												Bacteria	COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01314	330214.NIDE0884	7e-141	506.5	Bacteria	rhiI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944		ko:K15471					ko00000,ko01000,ko01008				Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_01315	330214.NIDE0885	3.6e-221	773.9	Nitrospirae	spsC		2.6.1.102	ko:K13010	ko00520,map00520		R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007				Bacteria	3J09X@40117,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_01316	330214.NIDE0886	4.6e-103	380.6	Bacteria	bplG												Bacteria	COG2148@1,COG2148@2	NA|NA|NA	M	undecaprenyl-phosphate glucose phosphotransferase activity
MAG.T21.41_01317	330214.NIDE0887	3.7e-274	950.7	Bacteria	capD	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	4.2.1.115,4.2.1.135,4.2.1.46	ko:K01710,ko:K15894,ko:K15912,ko:K19421	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R06513,R09697	RC00402,RC02609	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1086@1,COG1086@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_01319	314265.R2601_01410	3.7e-41	176.4	Alphaproteobacteria													Bacteria	1MW8V@1224,2U289@28211,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_01320	883078.HMPREF9695_00494	5e-28	130.2	Bradyrhizobiaceae				ko:K07483,ko:K07497					ko00000				Bacteria	1RGZ5@1224,2UAIS@28211,3K1PX@41294,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
MAG.T21.41_01321	288000.BBta_p0142	2.3e-89	335.1	Bradyrhizobiaceae													Bacteria	1MVN5@1224,2TQK0@28211,3JZ81@41294,COG2801@1,COG2801@2	NA|NA|NA	L	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01323	1396858.Q666_16420	1e-84	320.1	Gammaproteobacteria													Bacteria	1P9A0@1224,1RYUQ@1236,COG2308@1,COG2308@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_01331	298653.Franean1_0043	1.8e-171	610.5	Actinobacteria													Bacteria	2IBIZ@201174,COG1073@1,COG1073@2	NA|NA|NA	L	photosystem II stabilization
MAG.T21.41_01333	338966.Ppro_1126	1e-29	137.9	Deltaproteobacteria													Bacteria	1QV9T@1224,2X7S1@28221,43CGV@68525,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_01336	330214.NIDE4019	2.1e-247	861.3	Nitrospirae	gltX	GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iEC042_1314.EC042_2616,iIT341.HP0476	Bacteria	3J0CJ@40117,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAG.T21.41_01337	330214.NIDE4021	2.7e-107	394.8	Bacteria	poxF												Bacteria	COG1018@1,COG1018@2	NA|NA|NA	C	nitric oxide dioxygenase activity
MAG.T21.41_01338	330214.NIDE4022	1.9e-71	275.0	Nitrospirae	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840		ko:K04755					ko00000				Bacteria	3J1AM@40117,COG0633@1,COG0633@2	NA|NA|NA	C	2Fe-2S iron-sulfur cluster binding domain
MAG.T21.41_01339	330214.NIDE4023	1.4e-81	308.9	Nitrospirae	rrf2												Bacteria	3J18M@40117,COG1959@1,COG1959@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_01340	330214.NIDE4024	6.9e-223	779.6	Nitrospirae	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029			iPC815.YPO2896,iYL1228.KPN_02862	Bacteria	3J0AX@40117,COG1104@1,COG1104@2	NA|NA|NA	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
MAG.T21.41_01341	330214.NIDE4025	1.4e-65	255.4	Nitrospirae	iscU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564		ko:K04488					ko00000			iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055	Bacteria	3J123@40117,COG0822@1,COG0822@2	NA|NA|NA	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
MAG.T21.41_01342	330214.NIDE4026	8.4e-60	236.1	Nitrospirae	ycf57	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564		ko:K13628					ko00000,ko03016				Bacteria	3J17Y@40117,COG0316@1,COG0316@2	NA|NA|NA	S	Iron-sulphur cluster biosynthesis
MAG.T21.41_01343	330214.NIDE4027	1.7e-83	315.8	Nitrospirae	hscB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234		ko:K04082,ko:K05801					ko00000,ko03029,ko03110				Bacteria	3J1CS@40117,COG1076@1,COG1076@2	NA|NA|NA	O	DnaJ molecular chaperone homology domain
MAG.T21.41_01344	330214.NIDE4028	7.5e-306	1055.8	Nitrospirae				ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	3J0YD@40117,COG0443@1,COG0443@2	NA|NA|NA	O	Hsp70 protein
MAG.T21.41_01345	330214.NIDE4029	6.9e-30	136.0	Nitrospirae	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772											Bacteria	3J1CR@40117,COG2975@1,COG2975@2	NA|NA|NA	S	Iron-sulphur cluster assembly
MAG.T21.41_01346	330214.NIDE4030	0.0	1511.1	Nitrospirae	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iAF987.Gmet_0354	Bacteria	3J0BH@40117,COG5009@1,COG5009@2	NA|NA|NA	M	Penicillin-binding protein OB-like domain
MAG.T21.41_01347	330214.NIDE4031	0.0	1164.4	Nitrospirae	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840		ko:K06207					ko00000				Bacteria	3J10A@40117,COG1217@1,COG1217@2	NA|NA|NA	T	Elongation factor G C-terminus
MAG.T21.41_01349	330214.NIDE4033	4.6e-82	310.5	Nitrospirae			1.11.1.15	ko:K03564					ko00000,ko01000				Bacteria	3J12D@40117,COG1225@1,COG1225@2	NA|NA|NA	O	AhpC/TSA family
MAG.T21.41_01350	330214.NIDE4034	1.5e-55	221.9	Bacteria	bta		1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko01000,ko03110				Bacteria	COG0526@1,COG0526@2	NA|NA|NA	CO	cell redox homeostasis
MAG.T21.41_01351	330214.NIDE4035	2.9e-111	408.3	Bacteria													Bacteria	COG1262@1,COG1262@2	NA|NA|NA	T	PFAM Formylglycine-generating sulfatase enzyme
MAG.T21.41_01352	330214.NIDE4036	3.4e-42	177.6	Bacteria				ko:K02487,ko:K12543	ko02020,map02020	M00330,M00507			ko00000,ko00001,ko00002,ko02000,ko02022,ko02035,ko02044	1.B.17,3.A.1.109.4			Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_01353	257310.BB0908	4.7e-27	126.7	Alcaligenaceae													Bacteria	1NC5H@1224,2VJXT@28216,3T2IX@506,COG0553@1,COG0553@2	NA|NA|NA	KL	Superfamily II DNA RNA helicases, SNF2 family
MAG.T21.41_01354	511.JT27_01325	8.4e-93	346.7	Alcaligenaceae													Bacteria	1R0GZ@1224,28NQ0@1,2WA31@28216,2ZBPR@2,3T4CX@506	NA|NA|NA	S	Domain of unknown function (DUF4391)
MAG.T21.41_01355	330214.NIDE2328	4.7e-138	497.3	Bacteria	lmbP		2.7.1.168	ko:K07031	ko00540,map00540		R09770	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	COG2605@1,COG2605@2	NA|NA|NA	G	GHMP kinase
MAG.T21.41_01356	330214.NIDE2329	5.1e-78	297.7	Bacteria			2.7.7.71,3.1.3.82,3.1.3.83	ko:K03273,ko:K15669	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771,R09772	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	COG1208@1,COG1208@2	NA|NA|NA	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MAG.T21.41_01357	1244869.H261_02826	2e-62	246.1	Rhodospirillales			2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWRX@1224,2JSGM@204441,2TRA2@28211,COG3959@1,COG3959@2	NA|NA|NA	G	COG3959 Transketolase, N-terminal subunit
MAG.T21.41_01358	1430440.MGMSRv2_4181	2.1e-68	266.2	Rhodospirillales	tktC		2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWIX@1224,2JYPW@204441,2U2QX@28211,COG3958@1,COG3958@2	NA|NA|NA	G	Transketolase, pyrimidine binding domain
MAG.T21.41_01359	118166.JH976537_gene4476	8.6e-178	630.2	Oscillatoriales													Bacteria	1G3ZK@1117,1HH76@1150,COG1032@1,COG1032@2	NA|NA|NA	C	Elongator protein 3, MiaB family, Radical SAM
MAG.T21.41_01360	330214.NIDE2334	0.0	1650.6	Bacteria	celD			ko:K02453,ko:K07280,ko:K20444,ko:K20543	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko01000,ko01005,ko02000,ko02044	1.B.55.3,3.A.15,4.D.1.3	GT2,GT4		Bacteria	COG0438@1,COG0438@2,COG1215@1,COG1215@2,COG1216@1,COG1216@2,COG2227@1,COG2227@2,COG3118@1,COG3118@2	NA|NA|NA	O	belongs to the thioredoxin family
MAG.T21.41_01361	330214.NIDE2335	2.7e-113	415.2	Bacteria				ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	COG0859@1,COG0859@2	NA|NA|NA	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity
MAG.T21.41_01362	330214.NIDE2336	1e-270	939.1	Nitrospirae	cgeB			ko:K06320					ko00000				Bacteria	3J0ZZ@40117,COG4641@1,COG4641@2	NA|NA|NA	S	DUF based on E. rectale Gene description (DUF3880)
MAG.T21.41_01366	330214.NIDE3238	6.8e-244	849.7	Nitrospirae	fhlA			ko:K02584,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132				ko00000,ko00001,ko03000				Bacteria	3J1FR@40117,COG2203@1,COG2203@2,COG3829@1,COG3829@2	NA|NA|NA	KT	Evidence 2b Function of strongly homologous gene
MAG.T21.41_01367	330214.NIDE3239	3.3e-214	751.1	Nitrospirae				ko:K03543		M00701			ko00000,ko00002,ko02000	8.A.1.1			Bacteria	3J0NN@40117,COG1566@1,COG1566@2	NA|NA|NA	V	HlyD membrane-fusion protein of T1SS
MAG.T21.41_01368	330214.NIDE3240	5.2e-252	876.7	Nitrospirae													Bacteria	3J0N2@40117,COG1538@1,COG1538@2	NA|NA|NA	M	Evidence 2b Function of strongly homologous gene
MAG.T21.41_01369	330214.NIDE3241	4.9e-277	959.9	Nitrospirae	emrY			ko:K03446,ko:K07786	ko02020,map02020	M00701			ko00000,ko00001,ko00002,ko02000	2.A.1.3,2.A.1.3.36			Bacteria	3J0PC@40117,COG0477@1,COG2814@2	NA|NA|NA	U	Major Facilitator Superfamily
MAG.T21.41_01370	330214.NIDE3242	1.4e-135	489.2	Bacteria	focA			ko:K02598,ko:K06212,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3			Bacteria	COG2116@1,COG2116@2	NA|NA|NA	P	formate transmembrane transporter activity
MAG.T21.41_01371	330214.NIDE3244	0.0	1085.1	Bacteria	fleS		2.7.13.3	ko:K02668,ko:K07710,ko:K07711,ko:K10942	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00500,M00501,M00502,M00515			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	COG4191@1,COG4191@2,COG5278@1,COG5278@2	NA|NA|NA	T	phosphoserine phosphatase activity
MAG.T21.41_01372	330214.NIDE3245	1.7e-241	841.6	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_01373	330214.NIDE3246	1.2e-134	486.5	Bacteria			2.7.13.3	ko:K07683	ko02020,map02020	M00483			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_01374	330214.NIDE3247	4e-100	370.9	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_01376	330214.NIDE3249	1e-204	719.5	Nitrospirae	cusC			ko:K15725					ko00000,ko02000	1.B.17.2.2			Bacteria	3J1F2@40117,COG1538@1,COG1538@2	NA|NA|NA	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01377	330214.NIDE3250	1e-173	616.3	Nitrospirae	cusB			ko:K15727					ko00000,ko02000	8.A.1.2.1			Bacteria	3J15V@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01378	330214.NIDE3251	0.0	1570.4	Bacteria				ko:K15726					ko00000,ko02000	2.A.6.1.2			Bacteria	COG3696@1,COG3696@2	NA|NA|NA	P	silver ion transport
MAG.T21.41_01379	330214.NIDE3252	4.9e-40	170.2	Bacteria	sugE			ko:K11741					ko00000,ko02000	2.A.7.1			Bacteria	COG2076@1,COG2076@2	NA|NA|NA	P	Multidrug Resistance protein
MAG.T21.41_01383	330214.NIDE3254	5.2e-246	856.7	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_01385	1415780.JPOG01000001_gene883	8.8e-23	112.8	Xanthomonadales	ugd		1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000				Bacteria	1MW5U@1224,1RMVW@1236,1X4NT@135614,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T21.41_01386	666685.R2APBS1_3055	1.4e-132	479.6	Xanthomonadales	wecB		5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1QUYI@1224,1SZZW@1236,1X6NR@135614,COG0381@1,COG0381@2	NA|NA|NA	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MAG.T21.41_01387	314278.NB231_01693	1.5e-177	629.8	Chromatiales	wbpM		4.2.1.115	ko:K15894	ko00520,map00520		R09697	RC02609	ko00000,ko00001,ko01000				Bacteria	1MWKY@1224,1RNQ2@1236,1WW39@135613,COG1086@1,COG1086@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_01388	1395516.PMO01_19310	2e-61	243.0	Gammaproteobacteria	wbpL		2.7.8.33,2.7.8.35	ko:K02851,ko:K13007			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	1MWYW@1224,1RNAP@1236,COG0472@1,COG0472@2	NA|NA|NA	M	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)
MAG.T21.41_01389	522306.CAP2UW1_0116	9.8e-68	263.8	unclassified Betaproteobacteria	wbpV		5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	1KQGV@119066,1MX2J@1224,2VJHC@28216,COG0451@1,COG0451@2	NA|NA|NA	M	NAD(P)H-binding
MAG.T21.41_01390	1244869.H261_14045	2.3e-133	482.3	Rhodospirillales				ko:K00786					ko00000,ko01000				Bacteria	1MY5T@1224,2JSZJ@204441,2TSZW@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferase 4-like domain
MAG.T21.41_01391	1187851.A33M_0962	4.4e-127	461.8	Alphaproteobacteria													Bacteria	1MUJ4@1224,2U48V@28211,COG5360@1,COG5360@2	NA|NA|NA	S	Heparinase II/III N-terminus
MAG.T21.41_01392	84531.JMTZ01000047_gene1071	5.5e-223	780.8	Gammaproteobacteria													Bacteria	1QV3S@1224,1RRI1@1236,COG0673@1,COG0673@2,COG1063@1,COG1063@2	NA|NA|NA	E	Dehydrogenase
MAG.T21.41_01393	1120983.KB894574_gene875	7.5e-182	644.0	Rhodobiaceae			6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	1JN2N@119043,1MW4E@1224,2TSCY@28211,COG0367@1,COG0367@2	NA|NA|NA	E	Asparagine synthase
MAG.T21.41_01395	1453500.AT05_02975	9.1e-48	197.6	Bacteria													Bacteria	COG2227@1,COG2227@2	NA|NA|NA	H	3-demethylubiquinone-9 3-O-methyltransferase activity
MAG.T21.41_01396	1296416.JACB01000017_gene5210	1e-55	224.2	Flavobacteriia													Bacteria	1I6U4@117743,4PI68@976,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_01397	864051.BurJ1DRAFT_3182	1.4e-105	390.6	unclassified Burkholderiales	asnB1		6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	1KJWB@119065,1MW4E@1224,2VHBY@28216,COG0367@1,COG0367@2	NA|NA|NA	E	Asparagine synthase, glutamine-hydrolyzing
MAG.T21.41_01398	56780.SYN_01142	4.3e-46	192.2	Bacteria	wbpT			ko:K13003					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01399	1267535.KB906767_gene2223	7e-37	161.8	Bacteria				ko:K02847	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5			Bacteria	COG3307@1,COG3307@2	NA|NA|NA	M	-O-antigen
MAG.T21.41_01400	330214.NIDE4301	1.1e-66	259.6	Bacteria			1.1.1.25,2.3.1.128,4.2.1.10	ko:K03790,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	COG1670@1,COG1670@2	NA|NA|NA	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAG.T21.41_01401	330214.NIDE4302	4.4e-44	184.1	Bacteria				ko:K03668					ko00000				Bacteria	COG3187@1,COG3187@2	NA|NA|NA	O	response to heat
MAG.T21.41_01402	330214.NIDE4304	1e-114	419.5	Bacteria			3.5.1.28	ko:K11066,ko:K12287					ko00000,ko01000,ko01011,ko02044				Bacteria	COG3023@1,COG3023@2	NA|NA|NA	V	N-Acetylmuramoyl-L-alanine amidase
MAG.T21.41_01403	330214.NIDE4306	3.6e-89	334.7	Bacteria													Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_01404	330214.NIDE4307	1.9e-196	691.8	Bacteria	Z012_00180		3.1.1.5	ko:K10804	ko01040,map01040				ko00000,ko00001,ko01000,ko01004				Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_01405	530564.Psta_3098	2.3e-38	167.2	Planctomycetes													Bacteria	2IXJ9@203682,COG0457@1,COG0457@2,COG2755@1,COG2755@2	NA|NA|NA	E	Tetratricopeptide repeat
MAG.T21.41_01407	330214.NIDE4308	8.8e-58	229.6	Nitrospirae	ysmA			ko:K07107					ko00000,ko01000				Bacteria	3J1EV@40117,COG0824@1,COG0824@2	NA|NA|NA	S	Thioesterase-like superfamily
MAG.T21.41_01408	330214.NIDE1099	1.4e-177	629.0	Nitrospirae	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_3198	Bacteria	3J0GU@40117,COG0263@1,COG0263@2	NA|NA|NA	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MAG.T21.41_01409	330214.NIDE1100	1.9e-165	588.6	Nitrospirae	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03979					ko00000,ko01000,ko03009				Bacteria	3J0E3@40117,COG0536@1,COG0536@2	NA|NA|NA	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MAG.T21.41_01410	330214.NIDE1101	1.7e-41	174.9	Nitrospirae	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904		ko:K02899	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0RB@40117,COG0211@1,COG0211@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL27 family
MAG.T21.41_01411	330214.NIDE1102	4.2e-47	193.7	Nitrospirae	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02888	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0TM@40117,COG0261@1,COG0261@2	NA|NA|NA	J	This protein binds to 23S rRNA in the presence of protein L20
MAG.T21.41_01412	330214.NIDE1103	8.2e-157	559.7	Nitrospirae	ilvE		2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0BM@40117,COG0115@1,COG0115@2	NA|NA|NA	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAG.T21.41_01413	330214.NIDE1104	2.6e-45	188.0	Nitrospirae	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	3J0V0@40117,COG1314@1,COG1314@2	NA|NA|NA	U	Preprotein translocase SecG subunit
MAG.T21.41_01414	330214.NIDE1105	9.3e-112	409.8	Nitrospirae	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147			iJN746.PP_4715	Bacteria	3J0MW@40117,COG0149@1,COG0149@2	NA|NA|NA	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MAG.T21.41_01415	330214.NIDE1106	2.1e-219	768.1	Nitrospirae	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0DE@40117,COG0126@1,COG0126@2	NA|NA|NA	G	Phosphoglycerate kinase
MAG.T21.41_01416	330214.NIDE1107	2.3e-179	634.8	Nitrospirae	gap		1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	3J0D8@40117,COG0057@1,COG0057@2	NA|NA|NA	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MAG.T21.41_01417	330214.NIDE1108	0.0	1277.3	Nitrospirae	mutS2	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391		ko:K07456	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	3J0Y0@40117,COG1193@1,COG1193@2	NA|NA|NA	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MAG.T21.41_01418	330214.NIDE3284	6.9e-38	166.0	Nitrospirae			2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J117@40117,COG3829@1,COG3829@2,COG4191@1,COG4191@2,COG5000@1,COG5000@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_01419	330214.NIDE1110	2e-91	342.0	Bacteria	narP			ko:K02479,ko:K07685	ko02020,map02020	M00472			ko00000,ko00001,ko00002,ko02022				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_01423	330214.NIDE1114	2.8e-92	345.1	Bacteria	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02450		M00331			ko00000,ko00002,ko02044	9.B.42			Bacteria	COG3267@1,COG3267@2	NA|NA|NA		
MAG.T21.41_01424	330214.NIDE1115	1.9e-244	851.7	Bacteria			1.14.99.50	ko:K18912	ko00340,map00340		R11013	RC03323,RC03324	ko00000,ko00001,ko01000				Bacteria	COG0265@1,COG0265@2,COG1262@1,COG1262@2	NA|NA|NA	T	PFAM Formylglycine-generating sulfatase enzyme
MAG.T21.41_01425	330214.NIDE1116	0.0	1171.4	Nitrospirae			4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0XC@40117,COG2114@1,COG2114@2,COG4252@1,COG4252@2	NA|NA|NA	T	Adenylate cyclase
MAG.T21.41_01426	330214.NIDE1117	3.5e-67	261.2	Bacteria													Bacteria	2EKQ4@1,33EDV@2	NA|NA|NA	S	Bacterial SH3 domain homologues
MAG.T21.41_01427	330214.NIDE1118	2.7e-136	491.5	Nitrospirae													Bacteria	3J193@40117,COG4783@1,COG4783@2	NA|NA|NA	S	Peptidase family M48
MAG.T21.41_01428	330214.NIDE1119	4.5e-261	907.1	Bacteria			2.7.13.3	ko:K02482					ko00000,ko01000,ko01001,ko02022				Bacteria	COG4191@1,COG4191@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_01429	330214.NIDE0641	0.0	1407.5	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4773@1,COG4773@2	NA|NA|NA	P	Receptor
MAG.T21.41_01431	330214.NIDE0647	2e-40	171.8	Bacteria	exbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03559					ko00000,ko02000	1.A.30.2.1			Bacteria	COG0848@1,COG0848@2	NA|NA|NA	U	biopolymer transport protein
MAG.T21.41_01432	330214.NIDE0646	1.9e-58	231.9	Bacteria	exbB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03561,ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.1,1.A.30.2.2			Bacteria	COG0811@1,COG0811@2	NA|NA|NA	U	bacteriocin transport
MAG.T21.41_01433	330214.NIDE0635	7.7e-215	753.8	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG4771@2	NA|NA|NA	P	transport
MAG.T21.41_01435	153948.NAL212_1489	2.9e-81	310.1	Nitrosomonadales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1MUIH@1224,2VKC9@28216,372G4@32003,COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent Receptor Plug Domain
MAG.T21.41_01436	330214.NIDE0626	3.5e-137	495.0	Bacteria													Bacteria	COG4409@1,COG4409@2	NA|NA|NA	G	exo-alpha-(2->6)-sialidase activity
MAG.T21.41_01437	330214.NIDE0639	1.3e-303	1048.5	Bacteria													Bacteria	COG1506@1,COG1506@2	NA|NA|NA	E	serine-type peptidase activity
MAG.T21.41_01438	228410.NE0550	1.6e-115	422.9	Nitrosomonadales													Bacteria	1MXGY@1224,2VKWA@28216,372FU@32003,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_01439	228410.NE0556	2.2e-278	964.9	Nitrosomonadales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1QTT0@1224,2WGP0@28216,374M9@32003,COG4773@1,COG4773@2	NA|NA|NA	P	InterPro IPR000531 COGs COG1629
MAG.T21.41_01441	330214.NIDE0638	0.0	1299.3	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_01442	330214.NIDE0638	0.0	1349.3	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_01443	330214.NIDE0637	2.2e-175	622.1	Bacteria				ko:K07221					ko00000,ko02000	1.B.5.1			Bacteria	COG1228@1,COG1228@2	NA|NA|NA	Q	imidazolonepropionase activity
MAG.T21.41_01444	330214.NIDE0636	4.7e-25	119.8	Bacteria													Bacteria	COG2452@1,COG2452@2	NA|NA|NA	L	recombinase activity
MAG.T21.41_01445	330214.NIDE0635	1.8e-304	1051.6	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG4771@2	NA|NA|NA	P	transport
MAG.T21.41_01447	330214.NIDE0633	8.3e-64	250.0	Bacteria													Bacteria	COG0526@1,COG0526@2	NA|NA|NA	CO	cell redox homeostasis
MAG.T21.41_01448	330214.NIDE0632	1.2e-72	279.3	Bacteria													Bacteria	COG4409@1,COG4409@2	NA|NA|NA	G	exo-alpha-(2->6)-sialidase activity
MAG.T21.41_01450	420662.Mpe_B0559	4.7e-20	104.4	Bacteria													Bacteria	COG0537@1,COG0537@2	NA|NA|NA	FG	bis(5'-adenosyl)-triphosphatase activity
MAG.T21.41_01452	1220583.GOACH_39_00150	2.6e-34	152.9	Actinobacteria				ko:K07076					ko00000				Bacteria	2H951@201174,COG1708@1,COG1708@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T21.41_01453	330214.NIDE2247	0.0	1626.7	Nitrospirae	dnaE-2		2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	3J0FE@40117,COG0587@1,COG0587@2	NA|NA|NA	L	DNA-directed DNA polymerase
MAG.T21.41_01454	330214.NIDE2248	1.2e-168	599.4	Bacteria	dinB		2.7.7.7	ko:K02346					ko00000,ko01000,ko03400				Bacteria	COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAG.T21.41_01455	330214.NIDE2249	6.3e-75	287.0	Nitrospirae	lexA		3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	3J1C0@40117,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response)
MAG.T21.41_01456	1123261.AXDW01000010_gene340	6.6e-30	136.7	Xanthomonadales													Bacteria	1RKSC@1224,1T14S@1236,1X9RS@135614,2BECK@1,3283Q@2	NA|NA|NA	S	T4-like virus tail tube protein gp19
MAG.T21.41_01457	1144275.COCOR_02863	1.7e-137	497.3	Proteobacteria				ko:K06907					ko00000				Bacteria	1NSAQ@1224,COG3497@1,COG3497@2	NA|NA|NA	S	Phage tail sheath protein subtilisin-like domain
MAG.T21.41_01458	1123261.AXDW01000010_gene342	5.5e-51	207.2	Xanthomonadales													Bacteria	1RM2J@1224,1T14R@1236,1XA9H@135614,2BEKE@1,328BU@2	NA|NA|NA	S	T4-like virus tail tube protein gp19
MAG.T21.41_01459	1144275.COCOR_02861	7.5e-52	210.7	Proteobacteria													Bacteria	1NC3Q@1224,COG1652@1,COG1652@2	NA|NA|NA	L	Flagellar Assembly Protein A
MAG.T21.41_01461	1144275.COCOR_02859	4.8e-103	381.3	Myxococcales				ko:K06905					ko00000				Bacteria	1R67C@1224,2X3HN@28221,2YW57@29,4387V@68525,COG3500@1,COG3500@2	NA|NA|NA	S	Phage late control gene D protein (GPD)
MAG.T21.41_01462	84531.JMTZ01000038_gene3637	8.3e-83	313.5	Gammaproteobacteria													Bacteria	1MU7Q@1224,1RZ3X@1236,COG3501@1,COG3501@2	NA|NA|NA	S	protein and some similarities with VgrG protein
MAG.T21.41_01463	261292.Nit79A3_1012	1.9e-116	426.8	Proteobacteria													Bacteria	1R3A3@1224,28NRK@1,332DP@2	NA|NA|NA		
MAG.T21.41_01464	1144275.COCOR_02856	3.3e-33	147.9	Proteobacteria				ko:K06903					ko00000				Bacteria	1NCAC@1224,COG3628@1,COG3628@2	NA|NA|NA	S	GPW gp25 family protein
MAG.T21.41_01465	1144275.COCOR_02855	1.6e-194	686.4	Myxococcales													Bacteria	1MWKI@1224,2WM4B@28221,2YVXE@29,42Q9A@68525,COG3299@1,COG3299@2	NA|NA|NA	S	Baseplate J-like protein
MAG.T21.41_01466	351746.Pput_3918	5.4e-17	95.1	Gammaproteobacteria													Bacteria	1R54T@1224,1S34J@1236,COG5285@1,COG5285@2	NA|NA|NA	Q	Phytanoyl-CoA dioxygenase
MAG.T21.41_01468	1177928.TH2_19949	1.3e-08	67.0	Rhodospirillales				ko:K17285					ko00000,ko04147				Bacteria	1MXJJ@1224,2JU8Z@204441,2TTH6@28211,COG3391@1,COG3391@2	NA|NA|NA	S	TIGRFAM 40-residue YVTN family beta-propeller repeat protein
MAG.T21.41_01469	1411123.JQNH01000001_gene537	3.3e-311	1074.3	Alphaproteobacteria	pacS	GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	1MU08@1224,2TR80@28211,COG2217@1,COG2217@2	NA|NA|NA	P	P-type ATPase'
MAG.T21.41_01471	1038858.AXBA01000006_gene821	1.1e-150	540.0	Xanthobacteraceae	cueO												Bacteria	1MU0J@1224,2TQXH@28211,3EY57@335928,COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_01472	330214.NIDE3408	0.0	1335.9	Bacteria	ppk		2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019			iJN746.PP_5217	Bacteria	COG0855@1,COG0855@2	NA|NA|NA	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MAG.T21.41_01473	330214.NIDE3407	1.3e-146	525.8	Bacteria													Bacteria	2DME8@1,32QX1@2	NA|NA|NA		
MAG.T21.41_01474	330214.NIDE3406	6e-310	1069.3	Nitrospirae	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0ES@40117,COG0129@1,COG0129@2	NA|NA|NA	EG	Dehydratase family
MAG.T21.41_01475	671143.DAMO_0839	4.3e-59	235.0	Bacteria				ko:K07480					ko00000				Bacteria	COG1662@1,COG1662@2	NA|NA|NA	L	PFAM IS1 transposase
MAG.T21.41_01477	765913.ThidrDRAFT_4550	1e-17	97.4	Proteobacteria													Bacteria	1NK9V@1224,2F294@1,33V75@2	NA|NA|NA		
MAG.T21.41_01478	1121406.JAEX01000002_gene894	1.1e-62	246.5	Deltaproteobacteria													Bacteria	1PXZG@1224,2WTES@28221,42X4N@68525,COG0454@1,COG0456@2,COG1432@1,COG1432@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
MAG.T21.41_01479	330214.NIDE3405	1.1e-48	199.1	Bacteria	Z012_07375												Bacteria	COG3212@1,COG3212@2	NA|NA|NA	T	peptidase
MAG.T21.41_01480	330214.NIDE3404	1.6e-79	302.4	Bacteria													Bacteria	COG3678@1,COG3678@2	NA|NA|NA	NPTU	ATP-independent chaperone mediated protein folding
MAG.T21.41_01481	330214.NIDE3403	2.8e-98	364.8	Nitrospirae	marC			ko:K05595					ko00000,ko02000	2.A.95.1			Bacteria	3J0UZ@40117,COG2095@1,COG2095@2	NA|NA|NA	U	MarC family integral membrane protein
MAG.T21.41_01482	330214.NIDE3402	3.2e-160	571.2	Nitrospirae				ko:K05516					ko00000,ko03036,ko03110				Bacteria	3J0A7@40117,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MAG.T21.41_01483	330214.NIDE3401	1.1e-155	556.2	Bacteria				ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1			Bacteria	COG3842@1,COG3842@2	NA|NA|NA	P	ATPase activity
MAG.T21.41_01484	330214.NIDE3400	5.6e-136	490.3	Bacteria				ko:K02026		M00207			ko00000,ko00002,ko02000	3.A.1.1			Bacteria	COG0395@1,COG0395@2	NA|NA|NA	P	glycerophosphodiester transmembrane transport
MAG.T21.41_01485	330214.NIDE3399	3.8e-141	507.7	Bacteria	sugA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704		ko:K02025,ko:K10237,ko:K15771	ko02010,map02010	M00204,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2		iNJ661.Rv1236	Bacteria	COG1175@1,COG1175@2	NA|NA|NA	P	transmembrane transport
MAG.T21.41_01486	330214.NIDE3398	1.6e-202	712.2	Bacteria	thuE			ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17			Bacteria	COG1653@1,COG1653@2	NA|NA|NA	G	carbohydrate transport
MAG.T21.41_01488	330214.NIDE3397	2.1e-88	332.0	Bacteria			4.2.2.23	ko:K18197					ko00000,ko01000		PL11		Bacteria	COG1470@1,COG1470@2,COG4733@1,COG4733@2	NA|NA|NA	S	cell adhesion involved in biofilm formation
MAG.T21.41_01489	330214.NIDE3396	3.2e-159	567.8	Nitrospirae	tilS		2.8.1.15,6.3.4.19	ko:K04075,ko:K14058,ko:K21947			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Bacteria	3J0JK@40117,COG0037@1,COG0037@2	NA|NA|NA	H	PP-loop family
MAG.T21.41_01490	330214.NIDE3395	9.8e-15	85.5	Bacteria	thiS			ko:K03154	ko04122,map04122				ko00000,ko00001				Bacteria	COG2104@1,COG2104@2	NA|NA|NA	H	thiamine diphosphate biosynthetic process
MAG.T21.41_01492	330214.NIDE3393	5.2e-184	650.2	Nitrospirae	galT		2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0896	Bacteria	3J0ER@40117,COG1085@1,COG1085@2	NA|NA|NA	H	Galactose-1-phosphate uridyl transferase, N-terminal domain
MAG.T21.41_01493	330214.NIDE3392	0.0	1369.0	Nitrospirae													Bacteria	3J0AQ@40117,COG1449@1,COG1449@2	NA|NA|NA	G	Glycosyl hydrolase family 57
MAG.T21.41_01494	330214.NIDE3391	3.7e-43	181.0	Bacteria													Bacteria	COG5652@1,COG5652@2	NA|NA|NA		
MAG.T21.41_01496	330214.NIDE3390	7.9e-161	573.2	Nitrospirae	yrpG			ko:K13315	ko00523,ko01130,map00523,map01130	M00798,M00799	R11051,R11474	RC00897,RC01516	ko00000,ko00001,ko00002,ko01000				Bacteria	3J154@40117,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo/keto reductase family
MAG.T21.41_01497	330214.NIDE3389	6.4e-175	620.2	Nitrospirae		GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100		R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	3J15Y@40117,COG3178@1,COG3178@2	NA|NA|NA	S	Phosphotransferase enzyme family
MAG.T21.41_01498	330214.NIDE3388	5.2e-112	410.6	Nitrospirae	rmlA	GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.7.13,2.7.7.24,2.7.7.99	ko:K00966,ko:K00973,ko:K00992	ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130	M00114,M00361,M00362,M00793	R00885,R02328,R11025	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0QW@40117,COG1208@1,COG1208@2	NA|NA|NA	JM	Nucleotidyl transferase
MAG.T21.41_01499	330214.NIDE3387	4e-235	820.5	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_01500	330214.NIDE3386	2e-228	798.1	Nitrospirae													Bacteria	3J0IE@40117,COG4198@1,COG4198@2	NA|NA|NA	S	Protein of unknown function (DUF1015)
MAG.T21.41_01501	330214.NIDE3385	1.1e-184	652.5	Nitrospirae	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110		R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006			iYL1228.KPN_03597,ic_1306.c3945	Bacteria	3J0H0@40117,COG0142@1,COG0142@2	NA|NA|NA	H	Polyprenyl synthetase
MAG.T21.41_01502	330214.NIDE3384	0.0	2871.3	Nitrospirae	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230		R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000				Bacteria	3J0SV@40117,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2	NA|NA|NA	C	Conserved region in glutamate synthase
MAG.T21.41_01503	330214.NIDE3383	3.6e-271	940.3	Nitrospirae	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Bacteria	3J152@40117,COG0493@1,COG0493@2	NA|NA|NA	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
MAG.T21.41_01505	330214.NIDE3233	1.9e-33	148.3	Nitrospirae	yeaO												Bacteria	3J1F0@40117,COG3189@1,COG3189@2	NA|NA|NA	S	Protein of unknown function, DUF488
MAG.T21.41_01507	700598.Niako_1599	2.2e-14	85.5	Sphingobacteriia	ntrX												Bacteria	1IPCA@117747,4NE89@976,COG2204@1,COG2204@2	NA|NA|NA	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
MAG.T21.41_01509	330214.NIDE3226	0.0	1114.8	Bacteria	pepF			ko:K08602					ko00000,ko01000,ko01002				Bacteria	COG1164@1,COG1164@2	NA|NA|NA	E	metalloendopeptidase activity
MAG.T21.41_01511	330214.NIDE3224	3.8e-48	197.2	Bacteria	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02498					ko00000				Bacteria	COG3071@1,COG3071@2	NA|NA|NA	H	HemY protein
MAG.T21.41_01512	330214.NIDE3222	4.1e-154	550.8	Nitrospirae	acuC												Bacteria	3J0P2@40117,COG0123@1,COG0123@2	NA|NA|NA	BQ	Histone deacetylase domain
MAG.T21.41_01513	330214.NIDE3221	3.7e-235	820.5	Bacteria													Bacteria	COG3005@1,COG3005@2	NA|NA|NA	C	denitrification pathway
MAG.T21.41_01514	330214.NIDE3220	3.2e-161	574.3	Bacteria	rhdA		2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122		R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000				Bacteria	COG2897@1,COG2897@2	NA|NA|NA	P	thiosulfate sulfurtransferase activity
MAG.T21.41_01515	330214.NIDE3219	8.4e-12	76.6	Bacteria	smbP												Bacteria	2DQ5D@1,334TW@2	NA|NA|NA	S	Small metal-binding protein
MAG.T21.41_01516	330214.NIDE3218	1.6e-127	462.2	Nitrospirae													Bacteria	3J11H@40117,COG0388@1,COG0388@2	NA|NA|NA	S	Carbon-nitrogen hydrolase
MAG.T21.41_01517	330214.NIDE3217	2.4e-98	364.8	Bacteria	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07735					ko00000,ko03000				Bacteria	COG1678@1,COG1678@2	NA|NA|NA	K	ribonucleoside-diphosphate reductase activity
MAG.T21.41_01518	330214.NIDE3216	0.0	1678.3	Nitrospirae	uvrA2			ko:K03701	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	3J0ZV@40117,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MAG.T21.41_01519	330214.NIDE3215	6.5e-84	317.4	Bacteria	nat		2.3.1.118,2.3.1.5	ko:K00622,ko:K00675	ko00232,ko00633,ko00983,ko01100,ko01110,ko01120,ko05204,map00232,map00633,map00983,map01100,map01110,map01120,map05204		R07940,R08036,R08248,R08250,R11902	RC00004,RC00416,RC00962,RC02961	ko00000,ko00001,ko01000				Bacteria	COG2162@1,COG2162@2	NA|NA|NA	Q	arylamine N-acetyltransferase activity
MAG.T21.41_01520	443144.GM21_1441	3.8e-47	195.3	Desulfuromonadales				ko:K13572					ko00000,ko03051				Bacteria	1PE00@1224,2X5N2@28221,42T67@68525,43SWU@69541,COG2378@1,COG2378@2	NA|NA|NA	K	WYL domain
MAG.T21.41_01522	555779.Dthio_PD3506	2.2e-106	392.5	Proteobacteria													Bacteria	1NSGF@1224,2B1FR@1,31TWH@2	NA|NA|NA		
MAG.T21.41_01523	376733.IT41_03180	1.3e-17	97.8	Paracoccus	dnaG			ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	1MUHC@1224,2PVV6@265,2TRU2@28211,COG0358@1,COG0358@2	NA|NA|NA	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MAG.T21.41_01524	35841.BT1A1_1799	2.7e-38	164.9	Bacillus													Bacteria	1V6HC@1239,1ZH3D@1386,4HJA7@91061,COG2445@1,COG2445@2	NA|NA|NA	S	Protein of unknown function DUF86
MAG.T21.41_01525	330214.NIDE0028	8.7e-42	176.4	Bacteria													Bacteria	COG1669@1,COG1669@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T21.41_01526	1454004.AW11_01274	1.2e-25	122.1	Betaproteobacteria				ko:K03676,ko:K06191					ko00000,ko03110				Bacteria	1N8R4@1224,2WHH0@28216,COG0695@1,COG0695@2	NA|NA|NA	O	Thioredoxin domain
MAG.T21.41_01527	251221.35214162	1.3e-23	115.9	Cyanobacteria	ytcD												Bacteria	1G94R@1117,COG1733@1,COG1733@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_01529	330214.NIDE3206	7.3e-264	916.0	Bacteria			1.10.3.1,1.14.18.1	ko:K00422,ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00031,R00045,R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000				Bacteria	2DBCY@1,2Z8GH@2	NA|NA|NA	S	PFAM Tyrosinase
MAG.T21.41_01530	330214.NIDE3201	1.1e-53	215.7	Bacteria													Bacteria	2C4PS@1,2ZHNK@2	NA|NA|NA		
MAG.T21.41_01531	330214.NIDE3200	1.3e-161	575.9	Nitrospirae	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013				ko00000,ko00001,ko01000,ko03016				Bacteria	3J113@40117,COG1234@1,COG1234@2	NA|NA|NA	S	tRNA 3'-trailer cleavage
MAG.T21.41_01533	330214.NIDE3198	6e-264	916.4	Bacteria	tolC			ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821			ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2			Bacteria	COG1538@1,COG1538@2	NA|NA|NA	MU	efflux transmembrane transporter activity
MAG.T21.41_01535	330214.NIDE4062	7.5e-215	753.1	Bacteria	pcd	GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
MAG.T21.41_01536	330214.NIDE4061	6.4e-89	333.6	Bacteria				ko:K08234					ko00000				Bacteria	COG0346@1,COG0346@2	NA|NA|NA	E	lactoylglutathione lyase activity
MAG.T21.41_01537	330214.NIDE4060	4.8e-21	107.5	Nitrospirae	mauG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428					ko00000,ko01000				Bacteria	3J0GH@40117,COG1858@1,COG1858@2	NA|NA|NA	C	Di-haem cytochrome c peroxidase
MAG.T21.41_01538	330214.NIDE4060	1.8e-28	132.1	Nitrospirae	mauG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428					ko00000,ko01000				Bacteria	3J0GH@40117,COG1858@1,COG1858@2	NA|NA|NA	C	Di-haem cytochrome c peroxidase
MAG.T21.41_01540	886293.Sinac_0436	1.7e-13	82.8	Planctomycetes													Bacteria	2C5IF@1,2IZWG@203682,2Z9B7@2	NA|NA|NA	S	Protein of unknown function (DUF1264)
MAG.T21.41_01541	330214.NIDE4057	8.6e-46	189.9	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01543	330214.NIDE1463	8.2e-22	109.0	Nitrospirae	istB												Bacteria	3J0QU@40117,COG1484@1,COG1484@2	NA|NA|NA	L	Evidence 2b Function of strongly homologous gene
MAG.T21.41_01548	330214.NIDE4050	7.3e-64	250.4	Bacteria				ko:K06940					ko00000				Bacteria	COG0727@1,COG0727@2	NA|NA|NA	S	metal cluster binding
MAG.T21.41_01549	330214.NIDE4049	1.3e-91	342.4	Bacteria													Bacteria	2BXN6@1,2ZK04@2	NA|NA|NA		
MAG.T21.41_01550	330214.NIDE4047	3.3e-43	180.6	Bacteria	hup			ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	COG0776@1,COG0776@2	NA|NA|NA	L	regulation of translation
MAG.T21.41_01551	330214.NIDE4045	3e-41	174.1	Bacteria	moaD			ko:K03636	ko04122,map04122				ko00000,ko00001				Bacteria	COG1977@1,COG1977@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T21.41_01554	330214.NIDE3937	0.0	3302.3	Bacteria			1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_01555	330214.NIDE3939	3.8e-233	813.9	Bacteria													Bacteria	COG3829@1,COG3829@2	NA|NA|NA	T	transcription factor binding
MAG.T21.41_01557	330214.NIDE3881	8.1e-55	219.5	Bacteria				ko:K06039,ko:K07235	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	COG1553@1,COG1553@2	NA|NA|NA	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MAG.T21.41_01558	330214.NIDE3882	8e-207	726.5	Bacteria				ko:K12263					ko00000				Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01559	330214.NIDE3883	4.3e-91	340.9	Bacteria				ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01560	330214.NIDE3884	1.2e-190	672.5	Bacteria	sorA			ko:K07147					ko00000,ko01000				Bacteria	COG2041@1,COG2041@2	NA|NA|NA	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MAG.T21.41_01561	330214.NIDE3885	2.6e-62	244.6	Bacteria	ycaO			ko:K09136					ko00000,ko03009				Bacteria	COG1765@1,COG1765@2	NA|NA|NA	O	OsmC-like protein
MAG.T21.41_01562	330214.NIDE3886	7.6e-144	516.5	Nitrospirae	tsdA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0022900,GO:0042597,GO:0044237,GO:0044464,GO:0050338,GO:0055114	1.8.2.2	ko:K19713					ko00000,ko01000				Bacteria	3J12T@40117,COG3258@1,COG3258@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T21.41_01563	330214.NIDE3864	4.1e-30	137.5	Nitrospirae				ko:K12263					ko00000				Bacteria	3J1AX@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01564	330214.NIDE3936	3.5e-97	361.7	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_01565	693661.Arcve_0310	2.6e-53	215.7	Archaeoglobi	gufA			ko:K07238					ko00000,ko02000	2.A.5.5			Archaea	246ZF@183980,2XXNC@28890,COG0428@1,arCOG00576@2157	NA|NA|NA	P	PFAM zinc iron permease
MAG.T21.41_01566	1121957.ATVL01000011_gene3721	1.9e-15	88.6	Cytophagia													Bacteria	2DJ8B@1,32UCJ@2,47RZN@768503,4NTR0@976	NA|NA|NA		
MAG.T21.41_01567	472759.Nhal_2109	1.7e-88	332.4	Chromatiales				ko:K07238,ko:K11021					ko00000,ko02000,ko02042	2.A.5.5			Bacteria	1PMN6@1224,1SIQH@1236,1X1XX@135613,COG0428@1,COG0428@2	NA|NA|NA	P	ZIP Zinc transporter
MAG.T21.41_01569	395494.Galf_2194	3.9e-41	174.9	Nitrosomonadales													Bacteria	1QUPT@1224,2WCP5@28216,44WF7@713636,COG1472@1,COG1472@2	NA|NA|NA	G	Protein of unknown function (DUF3365)
MAG.T21.41_01570	671143.DAMO_1951	1.9e-27	129.4	Bacteria													Bacteria	COG3678@1,COG3678@2	NA|NA|NA	NPTU	ATP-independent chaperone mediated protein folding
MAG.T21.41_01571	404589.Anae109_3615	3.3e-85	321.6	delta/epsilon subdivisions	peb3			ko:K10938	ko05111,map05111				ko00000,ko00001				Bacteria	1N6UH@1224,42Q91@68525,COG4588@1,COG4588@2	NA|NA|NA	S	Bacterial extracellular solute-binding protein
MAG.T21.41_01572	330214.NIDE4060	2.4e-158	565.1	Nitrospirae	mauG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.11.1.5	ko:K00428					ko00000,ko01000				Bacteria	3J0GH@40117,COG1858@1,COG1858@2	NA|NA|NA	C	Di-haem cytochrome c peroxidase
MAG.T21.41_01573	330214.NIDE0670	6.5e-48	197.2	Bacteria													Bacteria	2BVVW@1,32175@2	NA|NA|NA	S	Cytochrome P460
MAG.T21.41_01574	56780.SYN_01164	7e-136	490.3	Deltaproteobacteria	hisD		1.1.1.23,2.6.1.9	ko:K00013,ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03243	RC00006,RC00099,RC00242,RC00463,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	1MW7I@1224,2WJDR@28221,42NCH@68525,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MAG.T21.41_01575	323261.Noc_0532	4.9e-34	151.0	Chromatiales	yhjR		2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	1QW29@1224,1S7N1@1236,1X10I@135613,COG4902@1,COG4902@2	NA|NA|NA		
MAG.T21.41_01576	314345.SPV1_01867	2.3e-12	79.0	Proteobacteria													Bacteria	1NAXP@1224,2DP44@1,330FI@2	NA|NA|NA	S	Cytochrome C'
MAG.T21.41_01577	749222.Nitsa_0554	5.5e-61	241.9	Epsilonproteobacteria	chrA			ko:K07240					ko00000,ko02000	2.A.51.1			Bacteria	1MUBW@1224,2YT01@29547,42QCN@68525,COG2059@1,COG2059@2	NA|NA|NA	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family
MAG.T21.41_01578	237368.SCABRO_03849	8e-104	384.0	Planctomycetes				ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	2IX01@203682,COG0767@1,COG0767@2	NA|NA|NA	Q	Belongs to the MlaE permease family
MAG.T21.41_01579	323097.Nham_4370	0.0	1598.9	Bradyrhizobiaceae	pgmB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576	2.4.1.216,2.4.1.64,2.4.1.8,3.1.3.12,3.2.1.28,5.4.2.6	ko:K00691,ko:K01087,ko:K01194,ko:K01838,ko:K03731,ko:K05342	ko00500,ko01100,map00500,map01100		R00010,R01555,R02727,R02728,R02778,R11310	RC00017,RC00049,RC00408	ko00000,ko00001,ko00537,ko01000		GH37,GH65		Bacteria	1MWJE@1224,2U1CG@28211,3JWWP@41294,COG0637@1,COG0637@2,COG1554@1,COG1554@2	NA|NA|NA	G	Glycosyl hydrolase family 65, C-terminal domain
MAG.T21.41_01580	420324.KI912022_gene340	0.0	1218.0	Methylobacteriaceae			2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35		Bacteria	1JT1D@119045,1MW4J@1224,2TRER@28211,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MAG.T21.41_01581	338966.Ppro_0419	2.5e-281	974.5	Desulfuromonadales	glgX		3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261		ko00000,ko00001,ko00002,ko01000		CBM48,GH13		Bacteria	1MU19@1224,2WKFS@28221,42P3J@68525,43U1C@69541,COG1523@1,COG1523@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 13 family
MAG.T21.41_01582	1038860.AXAP01000015_gene2094	0.0	1416.7	Bradyrhizobiaceae	xfp		4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120		R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000				Bacteria	1MVSE@1224,2TU2E@28211,3JRH2@41294,COG3957@1,COG3957@2	NA|NA|NA	G	aldehyde-lyase activity
MAG.T21.41_01583	859657.RPSI07_mp0767	9e-111	406.8	Betaproteobacteria													Bacteria	1R5ET@1224,2VP93@28216,COG1028@1,COG1028@2	NA|NA|NA	IQ	short chain dehydrogenase
MAG.T21.41_01584	1123399.AQVE01000048_gene395	7.2e-30	136.7	Proteobacteria													Bacteria	1R3CF@1224,2C6PE@1,333XY@2	NA|NA|NA		
MAG.T21.41_01585	330214.NIDE0039	4.1e-20	104.0	Bacteria													Bacteria	COG2329@1,COG2329@2	NA|NA|NA	S	heme oxygenase (decyclizing) activity
MAG.T21.41_01587	330214.NIDE3893	1.4e-24	119.0	Bacteria				ko:K12263					ko00000				Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_01588	330214.NIDE3910	5.6e-100	370.9	Nitrospirae		GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704	4.2.3.118	ko:K16218					ko00000,ko01000				Bacteria	3J1CW@40117,COG3170@1,COG3170@2	NA|NA|NA	NU	Protein of unknown function (DUF1207)
MAG.T21.41_01589	1123269.NX02_09210	3e-132	478.4	Sphingomonadales	yhhJ			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MUIA@1224,2K1I9@204457,2TU4P@28211,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T21.41_01590	177437.HRM2_48510	0.0	1235.7	Desulfobacterales				ko:K01990,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1QTT9@1224,2MJER@213118,2X713@28221,43BJ5@68525,COG0842@1,COG0842@2,COG1129@1,COG1129@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T21.41_01591	177437.HRM2_48520	8.7e-83	313.9	Desulfobacterales	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01993					ko00000				Bacteria	1MUG6@1224,2MPK8@213118,2WMKG@28221,42NC1@68525,COG0845@1,COG0845@2	NA|NA|NA	M	Biotin-lipoyl like
MAG.T21.41_01592	338963.Pcar_3003	6.7e-161	574.7	Deltaproteobacteria													Bacteria	1MYXE@1224,2WR7T@28221,42TA7@68525,COG1538@1,COG1538@2	NA|NA|NA	M	Outer membrane efflux protein
MAG.T21.41_01594	234267.Acid_3304	3.7e-161	574.3	Acidobacteria			1.1.1.14,1.2.1.46	ko:K00008,ko:K00148	ko00040,ko00051,ko00625,ko00680,ko01100,ko01120,ko01200,map00040,map00051,map00625,map00680,map01100,map01120,map01200	M00014	R00604,R00875,R01896	RC00085,RC00102,RC00188	ko00000,ko00001,ko00002,ko01000				Bacteria	3Y6JK@57723,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T21.41_01595	1242864.D187_001897	2.2e-56	224.9	delta/epsilon subdivisions			3.5.3.18	ko:K01482					ko00000,ko01000,ko04147				Bacteria	1RD1N@1224,431W1@68525,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
MAG.T21.41_01596	665942.HMPREF1022_01798	4.8e-76	290.8	Desulfovibrionales													Bacteria	1MVEH@1224,2MA3T@213115,2WKUR@28221,42MDR@68525,COG0667@1,COG0667@2	NA|NA|NA	C	PFAM aldo keto reductase
MAG.T21.41_01597	404380.Gbem_0402	5.3e-48	197.2	Deltaproteobacteria													Bacteria	1MVEH@1224,2WKUR@28221,42MDR@68525,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T21.41_01598	1123367.C666_10530	4.1e-12	78.2	Betaproteobacteria													Bacteria	1NPWH@1224,2BVI1@1,2W4HU@28216,32QWD@2	NA|NA|NA		
MAG.T21.41_01599	330214.NIDE1421	2e-264	917.9	Nitrospirae	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147			iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	Bacteria	3J0A1@40117,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MAG.T21.41_01600	330214.NIDE1420	0.0	1302.3	Bacteria													Bacteria	COG3391@1,COG3391@2	NA|NA|NA	CO	amine dehydrogenase activity
MAG.T21.41_01602	330214.NIDE1418	7.3e-100	370.5	Nitrospirae	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K06024					ko00000,ko03036				Bacteria	3J15Z@40117,COG1386@1,COG1386@2	NA|NA|NA	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MAG.T21.41_01603	330214.NIDE1417	2e-127	461.8	Nitrospirae	scpA			ko:K05896					ko00000,ko03036				Bacteria	3J13J@40117,COG1354@1,COG1354@2	NA|NA|NA	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MAG.T21.41_01604	330214.NIDE2490	3.9e-108	397.5	Bacteria													Bacteria	29ZH8@1,30MGZ@2	NA|NA|NA		
MAG.T21.41_01605	330214.NIDE2489	1.6e-206	725.3	Bacteria													Bacteria	28MEN@1,2ZASA@2	NA|NA|NA		
MAG.T21.41_01606	330214.NIDE2488	2.3e-188	664.8	Bacteria													Bacteria	28II6@1,2Z8JB@2	NA|NA|NA		
MAG.T21.41_01607	330214.NIDE2487	0.0	1129.8	Bacteria			2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1070@1,COG1070@2	NA|NA|NA	G	xylulokinase activity
MAG.T21.41_01608	330214.NIDE2486	1.2e-40	172.6	Bacteria													Bacteria	2EGJW@1,33AC1@2	NA|NA|NA		
MAG.T21.41_01611	309801.trd_1815	3.2e-50	205.3	Thermomicrobia	nrdJ		1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	27Y2V@189775,2G8RN@200795,COG0209@1,COG0209@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T21.41_01614	412597.AEPN01000025_gene338	1.6e-10	71.6	Paracoccus				ko:K07483					ko00000				Bacteria	1NH66@1224,2PXKS@265,2UD9V@28211,COG2963@1,COG2963@2	NA|NA|NA	L	Associated with IS66-like transposable element, conserved
MAG.T21.41_01617	1120705.FG95_02444	7.5e-21	106.3	Sphingomonadales													Bacteria	1NJT9@1224,2K44K@204457,2U243@28211,COG2253@1,COG2253@2	NA|NA|NA	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system
MAG.T21.41_01618	1446473.JHWH01000004_gene2720	1.8e-78	298.9	Alphaproteobacteria													Bacteria	1P6MT@1224,2U238@28211,COG5340@1,COG5340@2	NA|NA|NA	K	Transcriptional regulator, AbiEi antitoxin
MAG.T21.41_01619	1417296.U879_03780	7e-114	416.8	Alphaproteobacteria													Bacteria	1RGEN@1224,2U91S@28211,COG0553@1,COG0553@2	NA|NA|NA	KL	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MAG.T21.41_01622	330214.NIDE1871	1.2e-129	469.2	Nitrospirae	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016				Bacteria	3J0B8@40117,COG0689@1,COG0689@2	NA|NA|NA	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MAG.T21.41_01625	330214.NIDE1790	6.7e-133	480.7	Bacteria				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	COG4733@1,COG4733@2	NA|NA|NA	S	cellulase activity
MAG.T21.41_01626	330214.NIDE1793	3.8e-153	547.7	Bacteria	ompT	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009279,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0043170,GO:0044238,GO:0044425,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.23.48,3.4.23.49	ko:K01355,ko:K08477,ko:K08566,ko:K13520	ko01503,ko02020,map01503,map02020	M00744			ko00000,ko00001,ko00002,ko01000,ko01002,ko01504				Bacteria	COG4571@1,COG4571@2	NA|NA|NA	M	Outer membrane protease
MAG.T21.41_01628	330214.NIDE1794	1.5e-173	615.5	Bacteria	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K03727					ko00000,ko01000				Bacteria	COG4581@1,COG4581@2	NA|NA|NA	L	dead DEAH box helicase
MAG.T21.41_01629	330214.NIDE1795	0.0	1104.0	Bacteria	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K03727					ko00000,ko01000				Bacteria	COG4581@1,COG4581@2	NA|NA|NA	L	dead DEAH box helicase
MAG.T21.41_01630	330214.NIDE1796	4.8e-158	563.9	Nitrospirae	glgC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0BI@40117,COG0448@1,COG0448@2	NA|NA|NA	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAG.T21.41_01632	575540.Isop_2988	6.2e-44	184.9	Bacteria													Bacteria	2BQC7@1,32J7B@2	NA|NA|NA		
MAG.T21.41_01634	1366050.N234_11525	4.6e-148	532.3	Betaproteobacteria			1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002,ko01000	3.D.4.3			Bacteria	1MXBD@1224,2VHMB@28216,COG3278@1,COG3278@2	NA|NA|NA	C	Cytochrome c oxidase subunit
MAG.T21.41_01636	215803.DB30_8587	4.2e-63	248.1	Myxococcales			3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000				Bacteria	1P8U5@1224,2WPQ7@28221,2YV2X@29,42SY1@68525,COG1878@1,COG1878@2	NA|NA|NA	S	Putative cyclase
MAG.T21.41_01637	861208.AGROH133_13782	2.1e-97	363.6	Rhizobiaceae			2.7.7.65,4.6.1.1	ko:K01768,ko:K20958	ko00230,ko02025,ko04113,ko04213,ko05111,map00230,map02025,map04113,map04213,map05111	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	1MU2C@1224,2TS9V@28211,4B7IR@82115,COG3322@1,COG3322@2,COG5001@1,COG5001@2	NA|NA|NA	T	GGDEF domain
MAG.T21.41_01638	330214.NIDE0017	2.1e-27	127.9	Nitrospirae													Bacteria	3J1A6@40117,COG3369@1,COG3369@2	NA|NA|NA	S	Iron-binding zinc finger CDGSH type
MAG.T21.41_01639	330214.NIDE0016	8.2e-73	279.6	Bacteria			1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2514@1,COG2514@2	NA|NA|NA	S	catechol 2,3-dioxygenase activity
MAG.T21.41_01640	330214.NIDE0015	8.6e-58	229.6	Bacteria													Bacteria	2CIIF@1,315FB@2	NA|NA|NA		
MAG.T21.41_01641	330214.NIDE0014	1.6e-186	658.7	Bacteria			1.2.3.3,1.6.5.2,1.7.1.15	ko:K00158,ko:K00363,ko:K03809,ko:K05710	ko00130,ko00360,ko00620,ko00910,ko01100,ko01110,ko01120,ko01220,map00130,map00360,map00620,map00910,map01100,map01110,map01120,map01220	M00530,M00545	R00207,R00787,R02964,R03643,R03816,R06782,R06783	RC00098,RC00176,RC00819,RC02745	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0655@1,COG0655@2,COG2146@1,COG2146@2	NA|NA|NA	S	NAD(P)H dehydrogenase (quinone) activity
MAG.T21.41_01642	382464.ABSI01000011_gene2994	1.5e-37	162.5	Verrucomicrobiae													Bacteria	2DQ7E@1,2IUQR@203494,3353C@2,46SU5@74201	NA|NA|NA	S	Domain of unknown function (DUF5069)
MAG.T21.41_01643	330214.NIDE0012	6.5e-70	270.0	Bacteria	fosB2		4.4.1.5	ko:K01759	ko00620,map00620		R02530	RC00004,RC00740	ko00000,ko00001,ko01000				Bacteria	COG0346@1,COG0346@2	NA|NA|NA	E	lactoylglutathione lyase activity
MAG.T21.41_01644	330214.NIDE0011	4e-89	334.3	Bacteria													Bacteria	COG2761@1,COG2761@2	NA|NA|NA	Q	protein disulfide oxidoreductase activity
MAG.T21.41_01645	330214.NIDE0010	6.8e-62	243.4	Nitrospirae	yhhW_1			ko:K06911					ko00000				Bacteria	3J125@40117,COG1741@1,COG1741@2	NA|NA|NA	S	Pirin
MAG.T21.41_01646	102129.Lepto7375DRAFT_5349	5.9e-53	213.4	Oscillatoriales													Bacteria	1GBBG@1117,1HG5G@1150,COG3676@1,COG3676@2,COG3677@1,COG3677@2	NA|NA|NA	L	Transposase zinc-ribbon domain
MAG.T21.41_01647	1249627.D779_0358	5.9e-50	204.1	Chromatiales													Bacteria	1R7ZF@1224,1S6YQ@1236,1WYGX@135613,COG3676@1,COG3676@2,COG3677@1,COG3677@2	NA|NA|NA	L	ISXO2-like transposase domain
MAG.T21.41_01648	1198232.CYCME_2009	3.6e-24	118.2	Thiotrichales													Bacteria	1RFDC@1224,1SG1X@1236,4614H@72273,COG4185@1,COG4185@2	NA|NA|NA	S	Zeta toxin
MAG.T21.41_01649	1047013.AQSP01000127_gene472	5.2e-09	66.6	unclassified Bacteria				ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2NPMP@2323,COG4177@1,COG4177@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
MAG.T21.41_01650	497964.CfE428DRAFT_5706	1.7e-102	379.8	Verrucomicrobia													Bacteria	46SUD@74201,COG3344@1,COG3344@2	NA|NA|NA	L	Group II intron maturase-specific domain protein
MAG.T21.41_01651	93220.LV28_13535	4.4e-08	64.3	Burkholderiaceae													Bacteria	1KHMT@119060,1MYNI@1224,2VTDT@28216,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin-like
MAG.T21.41_01653	330214.NIDE0362	1.8e-307	1061.2	Nitrospirae	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363		ko:K03495			R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036				Bacteria	3J0E9@40117,COG0445@1,COG0445@2	NA|NA|NA	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MAG.T21.41_01654	330214.NIDE0361	3e-185	654.8	Nitrospirae	mnmE			ko:K03650			R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016				Bacteria	3J0JZ@40117,COG0486@1,COG0486@2	NA|NA|NA	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MAG.T21.41_01655	330214.NIDE0360	2.9e-275	954.1	Nitrospirae	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150		ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Bacteria	3J0GD@40117,COG0706@1,COG0706@2	NA|NA|NA	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
MAG.T21.41_01656	1127695.HMPREF9163_01252	5.6e-21	106.7	Negativicutes	yidD			ko:K03217,ko:K08998	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Bacteria	1VEIG@1239,4H5K3@909932,COG0759@1,COG0759@2	NA|NA|NA	S	Could be involved in insertion of integral membrane proteins into the membrane
MAG.T21.41_01657	330214.NIDE0359	1.7e-29	134.8	Bacteria	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998					ko00000,ko01000,ko03016				Bacteria	COG0594@1,COG0594@2	NA|NA|NA	J	ribonuclease P activity
MAG.T21.41_01658	1128912.GMES_4486	1.1e-07	61.6	Alteromonadaceae	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02914	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1NGGS@1224,1SGDJ@1236,4690G@72275,COG0230@1,COG0230@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL34 family
MAG.T21.41_01659	330214.NIDE0357	1.3e-172	612.5	Nitrospirae													Bacteria	3J19Y@40117,COG3034@1,COG3034@2	NA|NA|NA	S	L,D-transpeptidase catalytic domain
MAG.T21.41_01660	330214.NIDE0356	2.9e-267	927.5	Bacteria	tal		2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	COG0166@1,COG0166@2	NA|NA|NA	G	Belongs to the GPI family
MAG.T21.41_01661	330214.NIDE0355	1.1e-93	349.7	Nitrospirae	pgl		3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000				Bacteria	3J18W@40117,COG0363@1,COG0363@2	NA|NA|NA	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
MAG.T21.41_01662	330214.NIDE0354	9.7e-176	622.9	Nitrospirae	glk		2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	3J13D@40117,COG0837@1,COG0837@2	NA|NA|NA	F	Glucokinase
MAG.T21.41_01663	330214.NIDE0353	4e-106	391.0	Bacteria	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.7.1.12,2.7.1.15,5.3.1.6	ko:K00851,ko:K00852,ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01051,R01056,R01737,R02750	RC00002,RC00017,RC00434	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0120@1,COG0120@2	NA|NA|NA	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MAG.T21.41_01664	330214.NIDE0352	0.0	1413.3	Nitrospirae	pepN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	3J0Y4@40117,COG0308@1,COG0308@2	NA|NA|NA	E	Peptidase family M1 domain
MAG.T21.41_01665	330214.NIDE0351	0.0	1370.9	Bacteria	MA20_43810			ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG3127@1,COG3127@2	NA|NA|NA	Q	FtsX-like permease family
MAG.T21.41_01666	330214.NIDE0350	1.3e-101	375.9	Bacteria				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG1136@1,COG1136@2	NA|NA|NA	V	lipoprotein transporter activity
MAG.T21.41_01667	330214.NIDE0349	4.2e-89	334.7	Bacteria	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_01669	330214.NIDE0347	1.4e-102	379.4	Bacteria	yehQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	COG4715@1,COG4715@2	NA|NA|NA	S	zinc ion binding
MAG.T21.41_01670	330214.NIDE0346	2e-130	472.2	Bacteria	phuW												Bacteria	COG3016@1,COG3016@2	NA|NA|NA	S	Haem-binding uptake, Tiki superfamily, ChaN
MAG.T21.41_01672	330214.NIDE0344	5.5e-149	533.9	Nitrospirae				ko:K03924					ko00000,ko01000				Bacteria	3J0WQ@40117,COG0714@1,COG0714@2	NA|NA|NA	S	ATPase family associated with various cellular activities (AAA)
MAG.T21.41_01673	330214.NIDE0343	1.2e-139	503.1	Bacteria													Bacteria	COG1721@1,COG1721@2	NA|NA|NA	E	protein (some members contain a von Willebrand factor type A (vWA) domain
MAG.T21.41_01674	330214.NIDE0342	2.4e-290	1004.6	Nitrospirae			2.3.2.13	ko:K22452					ko00000,ko01000				Bacteria	3J150@40117,COG1305@1,COG1305@2	NA|NA|NA	E	Transglutaminase/protease-like homologues
MAG.T21.41_01675	330214.NIDE3710	1.2e-25	122.5	Nitrospirae	arsR			ko:K03892,ko:K21903					ko00000,ko03000				Bacteria	3J1BW@40117,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T21.41_01676	330214.NIDE3708	1.3e-140	506.1	Nitrospirae	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656		ko:K03325					ko00000,ko02000	2.A.59			Bacteria	3J0XN@40117,COG0798@1,COG0798@2	NA|NA|NA	P	Sodium Bile acid symporter family
MAG.T21.41_01678	856793.MICA_623	8.5e-44	183.3	unclassified Alphaproteobacteria	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620		R02530	RC00004,RC00740	ko00000,ko00001,ko01000				Bacteria	1RHIV@1224,2TR4K@28211,4BSC6@82117,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MAG.T21.41_01679	856793.MICA_622	4.5e-50	204.1	unclassified Alphaproteobacteria	arsC		1.20.4.1	ko:K03741,ko:K03892					ko00000,ko01000,ko03000				Bacteria	1MWYQ@1224,2TU1U@28211,4BQM3@82117,COG0394@1,COG0394@2	NA|NA|NA	T	Low molecular weight phosphatase family
MAG.T21.41_01680	643473.KB235931_gene4687	2e-91	342.8	Nostocales	pstS	GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234		ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	1FZZ0@1117,1HIWF@1161,COG0226@1,COG0226@2	NA|NA|NA	P	Phosphate ABC transporter substrate-binding protein, PhoT family
MAG.T21.41_01682	330214.NIDE2695	3.1e-218	764.2	Bacteria				ko:K20306					ko00000,ko04131				Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_01684	330214.NIDE2697	1.7e-197	695.3	Bacteria	capM												Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01685	330214.NIDE2698	5.5e-154	550.4	Bacteria													Bacteria	COG0726@1,COG0726@2	NA|NA|NA	G	polysaccharide deacetylase
MAG.T21.41_01686	1230476.C207_02141	4e-42	178.7	Alphaproteobacteria													Bacteria	1N62D@1224,2E2DZ@1,2UENG@28211,32XIP@2	NA|NA|NA		
MAG.T21.41_01687	330214.NIDE2699	1.4e-281	975.3	Bacteria	asnB		6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	COG0367@1,COG0367@2	NA|NA|NA	E	asparagine synthase
MAG.T21.41_01688	330214.NIDE2700	1.7e-170	605.5	Bacteria	wbpT			ko:K13003					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01689	330214.NIDE2720	1.5e-130	473.0	Bacteria			3.2.1.202	ko:K21606					ko00000,ko01000		CBM5,GH18		Bacteria	COG3866@1,COG3866@2	NA|NA|NA	G	Pectate lyase
MAG.T21.41_01690	41431.PCC8801_2281	7.4e-82	311.2	Cyanothece													Bacteria	1G060@1117,3KHHI@43988,COG2755@1,COG2755@2	NA|NA|NA	E	GDSL-like Lipase/Acylhydrolase
MAG.T21.41_01691	330214.NIDE2702	6e-97	361.3	Bacteria				ko:K18814					ko00000,ko02000	9.B.67.1			Bacteria	COG3307@1,COG3307@2	NA|NA|NA	M	-O-antigen
MAG.T21.41_01692	330214.NIDE2703	5.5e-161	573.9	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01695	935848.JAEN01000002_gene963	1.3e-09	72.0	Paracoccus													Bacteria	1MU7T@1224,2PYJ0@265,2TRVY@28211,COG2931@1,COG2931@2	NA|NA|NA	Q	Haemolysin-type calcium-binding repeat (2 copies)
MAG.T21.41_01698	1185766.DL1_08305	1.7e-83	315.5	Thioclava	phnC	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015416,GO:0015604,GO:0015605,GO:0015698,GO:0015716,GO:0015748,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:0099133	3.6.3.28	ko:K02041	ko02010,map02010	M00223			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9			Bacteria	1MVE9@1224,2TRR3@28211,2XNYS@285107,COG3638@1,COG3638@2	NA|NA|NA	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MAG.T21.41_01699	330214.NIDE3855	1.9e-20	104.4	Bacteria													Bacteria	COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAG.T21.41_01700	330214.NIDE3856	2.3e-111	408.3	Bacteria				ko:K07074					ko00000				Bacteria	COG3541@1,COG3541@2	NA|NA|NA	L	Predicted nucleotidyltransferase
MAG.T21.41_01701	330214.NIDE3859	5.5e-75	287.0	Nitrospirae	ibpA			ko:K13993	ko04141,map04141				ko00000,ko00001,ko03110				Bacteria	3J0TV@40117,COG0071@1,COG0071@2	NA|NA|NA	O	Belongs to the small heat shock protein (HSP20) family
MAG.T21.41_01703	330214.NIDE3860	9.8e-99	366.3	Nitrospirae	prsT			ko:K07100					ko00000				Bacteria	3J18T@40117,COG1926@1,COG1926@2	NA|NA|NA	S	Phosphoribosyl transferase domain
MAG.T21.41_01704	330214.NIDE3861	8.9e-76	289.7	Bacteria													Bacteria	COG1499@1,COG1499@2	NA|NA|NA	J	amine dehydrogenase activity
MAG.T21.41_01706	330214.NIDE3863	2.9e-143	514.6	Bacteria													Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_01707	330214.NIDE3864	1.8e-57	228.4	Nitrospirae				ko:K12263					ko00000				Bacteria	3J1AX@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01708	330214.NIDE3865	1.8e-135	489.2	Bacteria													Bacteria	COG0695@1,COG0695@2	NA|NA|NA	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MAG.T21.41_01709	330214.NIDE3866	0.0	1508.0	Nitrospirae	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120		R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004				Bacteria	3J0ZI@40117,COG0045@1,COG0045@2,COG1042@1,COG1042@2,COG1670@1,COG1670@2	NA|NA|NA	C	ATP-grasp domain
MAG.T21.41_01710	1116472.MGMO_118c00020	9.4e-25	119.4	Gammaproteobacteria													Bacteria	1N9U3@1224,1SSRU@1236,COG5304@1,COG5304@2	NA|NA|NA		
MAG.T21.41_01712	1123257.AUFV01000026_gene4	9.7e-07	60.5	Xanthomonadales	cbcC												Bacteria	1QZ6I@1224,1RXZD@1236,1X8R4@135614,COG3005@1,COG3005@2	NA|NA|NA	C	denitrification pathway
MAG.T21.41_01713	330214.NIDE3869	2.7e-79	301.6	Bacteria													Bacteria	296YQ@1,2ZU7A@2	NA|NA|NA		
MAG.T21.41_01715	330214.NIDE3871	2.4e-78	298.1	Bacteria													Bacteria	COG5592@1,COG5592@2	NA|NA|NA	I	hemerythrin HHE cation binding domain
MAG.T21.41_01716	314345.SPV1_01867	2.3e-07	62.4	Proteobacteria													Bacteria	1NAXP@1224,2DP44@1,330FI@2	NA|NA|NA	S	Cytochrome C'
MAG.T21.41_01717	330214.NIDE3873	6.1e-163	580.1	Nitrospirae			1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KG@40117,COG1013@1,COG1013@2	NA|NA|NA	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
MAG.T21.41_01718	330214.NIDE3874	3e-205	721.1	Nitrospirae	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0HY@40117,COG0674@1,COG0674@2	NA|NA|NA	C	Pyruvate:ferredoxin oxidoreductase core domain II
MAG.T21.41_01719	330214.NIDE3875	7.3e-108	397.1	Nitrospirae	porD		1.2.1.58,1.2.7.1	ko:K00171,ko:K00172,ko:K18357,ko:K18358	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0TG@40117,COG1014@1,COG1014@2,COG1144@1,COG1144@2	NA|NA|NA	C	Pyruvate ferredoxin/flavodoxin oxidoreductase
MAG.T21.41_01720	330214.NIDE3876	2.2e-32	144.8	Nitrospirae	XK27_07760												Bacteria	3J1B3@40117,COG4980@1,COG4980@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_01721	330214.NIDE3877	1.8e-72	278.5	Bacteria	trxC		1.8.1.8	ko:K03672					ko00000,ko01000,ko03110				Bacteria	COG3118@1,COG3118@2	NA|NA|NA	O	belongs to the thioredoxin family
MAG.T21.41_01722	330214.NIDE3879	7.1e-50	203.8	Nitrospirae													Bacteria	3J17C@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T21.41_01723	671143.DAMO_1960	3.8e-188	664.5	Bacteria				ko:K21601					ko00000,ko03000				Bacteria	COG4314@1,COG4314@2	NA|NA|NA	C	lipoprotein involved in nitrous oxide reduction
MAG.T21.41_01725	443143.GM18_4120	3.3e-22	111.7	Deltaproteobacteria	tlpA												Bacteria	1Q3FH@1224,2WRZR@28221,43A8D@68525,COG0526@1,COG0526@2	NA|NA|NA	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAG.T21.41_01726	671143.DAMO_1959	2.9e-53	214.9	Bacteria													Bacteria	COG4314@1,COG4314@2	NA|NA|NA	C	lipoprotein involved in nitrous oxide reduction
MAG.T21.41_01727	671143.DAMO_1958	9.9e-135	486.5	Bacteria													Bacteria	28K4S@1,2Z9TM@2	NA|NA|NA		
MAG.T21.41_01728	671143.DAMO_1957	2.2e-90	338.6	unclassified Bacteria				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2NP53@2323,COG1136@1,COG1136@2	NA|NA|NA	V	ABC transporter
MAG.T21.41_01729	671143.DAMO_1956	2.5e-159	568.5	Bacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG4591@1,COG4591@2	NA|NA|NA	M	lipoprotein localization to outer membrane
MAG.T21.41_01730	671143.DAMO_1955	9.3e-23	112.8	Bacteria													Bacteria	2E5GP@1,3308B@2	NA|NA|NA		
MAG.T21.41_01732	330214.NIDE3880	4.3e-106	390.6	Bacteria			2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	COG2326@1,COG2326@2	NA|NA|NA	S	polyphosphate kinase activity
MAG.T21.41_01733	1123320.KB889662_gene1590	2e-111	409.1	Actinobacteria													Bacteria	2GMNA@201174,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T21.41_01734	1179773.BN6_41840	2.1e-143	515.4	Pseudonocardiales													Bacteria	2GIY3@201174,4DXE3@85010,COG2141@1,COG2141@2	NA|NA|NA	C	PFAM Luciferase-like monooxygenase
MAG.T21.41_01735	261292.Nit79A3_0056	2.7e-24	118.2	Nitrosomonadales		GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704	4.2.3.118	ko:K16218					ko00000,ko01000				Bacteria	1QDEM@1224,2WBDF@28216,372WN@32003,COG3170@1,COG3170@2	NA|NA|NA	NU	Protein of unknown function (DUF1207)
MAG.T21.41_01738	631362.Thi970DRAFT_01557	3.5e-68	266.9	Proteobacteria	ydfH		2.7.13.3	ko:K07675,ko:K07814,ko:K11623	ko02020,map02020	M00473,M00484			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1R7HC@1224,COG2197@1,COG2197@2,COG2199@1,COG2202@1,COG2202@2,COG3706@2,COG4585@1,COG4585@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T21.41_01739	1380355.JNIJ01000028_gene716	4.7e-72	279.3	Bradyrhizobiaceae	exsG		2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	1NWNJ@1224,2TZ8H@28211,3JXDQ@41294,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2461@1,COG2461@2,COG3920@1,COG3920@2	NA|NA|NA	T	Histidine kinase-like ATPase domain
MAG.T21.41_01740	631362.Thi970DRAFT_01557	2.1e-65	257.3	Proteobacteria	ydfH		2.7.13.3	ko:K07675,ko:K07814,ko:K11623	ko02020,map02020	M00473,M00484			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1R7HC@1224,COG2197@1,COG2197@2,COG2199@1,COG2202@1,COG2202@2,COG3706@2,COG4585@1,COG4585@2	NA|NA|NA	T	Diguanylate cyclase
MAG.T21.41_01741	1210884.HG799463_gene9352	2.2e-52	212.2	Planctomycetes	cheB		3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	2IZA0@203682,COG2201@1,COG2201@2	NA|NA|NA	NT	CheB methylesterase
MAG.T21.41_01742	1210884.HG799463_gene9351	8.6e-111	406.8	Planctomycetes	cheR		2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko01000,ko02035				Bacteria	2IXV1@203682,COG1352@1,COG1352@2	NA|NA|NA	NT	Methyltransferase, chemotaxis proteins
MAG.T21.41_01743	1210884.HG799463_gene9350	2.2e-289	1001.9	Planctomycetes													Bacteria	2IXNT@203682,COG0745@1,COG0745@2,COG2199@1,COG3706@2,COG4251@1,COG4251@2	NA|NA|NA	T	CHASE3 domain
MAG.T21.41_01744	1173026.Glo7428_2092	1.3e-248	867.1	Cyanobacteria				ko:K07814					ko00000,ko02022				Bacteria	1G09B@1117,COG0642@1,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_01747	472759.Nhal_1635	3.7e-177	628.6	Chromatiales			3.1.4.4	ko:K01115	ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231		R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000,ko04131				Bacteria	1MV8I@1224,1RSB6@1236,1WXPA@135613,COG0398@1,COG0398@2,COG1502@1,COG1502@2	NA|NA|NA	I	PFAM SNARE associated Golgi protein
MAG.T21.41_01748	1266925.JHVX01000002_gene813	2.3e-56	225.7	Nitrosomonadales													Bacteria	1MVN7@1224,2VQ9I@28216,371PA@32003,COG3568@1,COG3568@2	NA|NA|NA	L	Endonuclease/Exonuclease/phosphatase family
MAG.T21.41_01751	795666.MW7_0150	2.1e-17	96.7	Burkholderiaceae													Bacteria	1K3XE@119060,1RDKU@1224,2DMIH@1,2VR1F@28216,32RT1@2	NA|NA|NA		
MAG.T21.41_01752	1502852.FG94_01041	3.2e-11	73.9	Oxalobacteraceae	ku	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363		ko:K10979	ko03450,map03450				ko00000,ko00001,ko03400				Bacteria	1N4UX@1224,2VJE3@28216,472N1@75682,COG1273@1,COG1273@2	NA|NA|NA	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MAG.T21.41_01754	234267.Acid_0218	1.6e-197	696.0	Acidobacteria	treZ-2		3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000		CBM48,GH13		Bacteria	3Y33J@57723,COG0296@1,COG0296@2	NA|NA|NA	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase
MAG.T21.41_01755	1254432.SCE1572_41890	8e-175	620.5	Myxococcales													Bacteria	1MW01@1224,2WJF7@28221,2YX9T@29,42NSN@68525,COG3408@1,COG3408@2	NA|NA|NA	G	High confidence in function and specificity
MAG.T21.41_01756	395019.Bmul_6253	5e-13	80.5	Burkholderiaceae	ligD		6.5.1.1	ko:K01971	ko03450,map03450		R00381	RC00005	ko00000,ko00001,ko01000,ko03400				Bacteria	1KBUI@119060,1QDD9@1224,2WE5T@28216,COG1793@1,COG1793@2	NA|NA|NA	L	ATP dependent DNA ligase C terminal region
MAG.T21.41_01758	221288.JH992900_gene319	3.8e-47	194.1	Stigonemataceae	M1-951												Bacteria	1G65D@1117,1JKYE@1189,COG4288@1,COG4288@2	NA|NA|NA	S	Anabaena sensory rhodopsin transducer
MAG.T21.41_01759	204669.Acid345_2151	4.2e-229	800.8	Acidobacteriia	spxB		1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100		R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000			iSB619.SA_RS13340	Bacteria	2JITT@204432,3Y3QI@57723,COG0028@1,COG0028@2	NA|NA|NA	EH	Belongs to the TPP enzyme family
MAG.T21.41_01760	472759.Nhal_2852	1.1e-76	293.9	Bacteria	tqsA			ko:K03548					ko00000,ko02000	2.A.86.1			Bacteria	COG0628@1,COG0628@2	NA|NA|NA	D	permease
MAG.T21.41_01761	316067.Geob_2601	2.9e-59	235.7	Desulfuromonadales	rbn			ko:K03466,ko:K07058					ko00000,ko03036	3.A.12			Bacteria	1MXQA@1224,2X2G7@28221,437BB@68525,43V98@69541,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T21.41_01767	292415.Tbd_2258	1.9e-107	396.0	Hydrogenophilales	gfo		1.1.99.28	ko:K00118					ko00000,ko01000				Bacteria	1KTHN@119069,1PF0E@1224,2W9B2@28216,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, NAD-binding Rossmann fold
MAG.T21.41_01770	1123376.AUIU01000016_gene234	5.8e-09	67.0	Bacteria				ko:K04065					ko00000				Bacteria	COG2823@1,COG2823@2	NA|NA|NA	S	hyperosmotic response
MAG.T21.41_01772	63737.Npun_R3103	1.5e-112	412.9	Nostocales	yxnA												Bacteria	1GQ39@1117,1HREB@1161,COG4221@1,COG4221@2	NA|NA|NA	S	Enoyl-(Acyl carrier protein) reductase
MAG.T21.41_01774	1279009.ADICEAN_02250	9.1e-19	99.8	Cytophagia			2.3.1.94,5.1.3.2	ko:K01784,ko:K10817,ko:K12443,ko:K15672	ko00052,ko00520,ko00522,ko01051,ko01052,ko01100,ko01130,map00052,map00520,map00522,map01051,map01052,map01100,map01130	M00361,M00362,M00632,M00774	R00291,R00918,R02984	RC00004,RC00289,RC02825,RC02826,RC02828,RC02829,RC02830,RC02831	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008				Bacteria	47W2D@768503,4NVIQ@976,COG0451@1,COG0451@2	NA|NA|NA	GM	SPW repeat
MAG.T21.41_01775	1185876.BN8_06419	4.1e-59	234.6	Cytophagia			4.1.1.35	ko:K00754,ko:K08678,ko:K13613	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008		GT4		Bacteria	47P8P@768503,4NN4T@976,COG0451@1,COG0451@2	NA|NA|NA	GM	Vitamin K epoxide reductase family
MAG.T21.41_01776	312153.Pnuc_1203	4.2e-141	508.1	Burkholderiaceae													Bacteria	1KG7J@119060,1QU77@1224,2WHGJ@28216,COG1506@1,COG1506@2	NA|NA|NA	E	PFAM secretory lipase
MAG.T21.41_01777	391613.RTM1035_06938	1.7e-87	329.3	Alphaproteobacteria				ko:K03286					ko00000,ko02000	1.B.6			Bacteria	1R3Z1@1224,2U1SQ@28211,COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_01778	1123255.JHYS01000008_gene3126	6.7e-58	232.3	Comamonadaceae													Bacteria	1MWN8@1224,2VPRX@28216,4AESB@80864,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_01779	1123255.JHYS01000005_gene789	1.1e-42	180.3	Comamonadaceae													Bacteria	1MZQA@1224,2VVEX@28216,4AF12@80864,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T21.41_01780	1267534.KB906755_gene4464	2.3e-19	102.8	Bacteria													Bacteria	2C2X7@1,31WBU@2	NA|NA|NA		
MAG.T21.41_01781	1122214.AQWH01000017_gene4662	2.8e-25	120.9	Alphaproteobacteria													Bacteria	1RIDI@1224,2UAG1@28211,COG3831@1,COG3831@2	NA|NA|NA	S	PFAM WGR domain
MAG.T21.41_01782	314271.RB2654_09359	9.2e-32	143.3	Alphaproteobacteria													Bacteria	1NEMD@1224,2E9ZQ@1,2UH5U@28211,33454@2	NA|NA|NA		
MAG.T21.41_01783	371731.Rsw2DRAFT_1980	0.0	1250.7	Proteobacteria													Bacteria	1QZFK@1224,COG0286@1,COG0286@2,COG4889@1,COG4889@2	NA|NA|NA	L	type iii restriction
MAG.T21.41_01784	330214.NIDE2972	2.6e-186	658.3	Nitrospirae			3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Bacteria	3J0MT@40117,COG0860@1,COG0860@2	NA|NA|NA	M	Ami_3
MAG.T21.41_01785	330214.NIDE2971	1.1e-74	286.2	Nitrospirae	yacP			ko:K06962					ko00000				Bacteria	3J0TU@40117,COG3688@1,COG3688@2	NA|NA|NA	S	YacP-like NYN domain
MAG.T21.41_01786	330214.NIDE2970	2.5e-133	481.5	Nitrospirae	ycfH	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575		ko:K03424					ko00000,ko01000				Bacteria	3J0KM@40117,COG0084@1,COG0084@2	NA|NA|NA	L	TatD related DNase
MAG.T21.41_01787	330214.NIDE2969	1.3e-193	682.2	Bacteria	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2375,iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934	Bacteria	COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MAG.T21.41_01788	330214.NIDE2967	0.0	1590.1	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_01789	330214.NIDE4172	7.3e-103	379.8	Nitrospirae	capI		5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100		R01385	RC00289	ko00000,ko00001,ko01000				Bacteria	3J0ZC@40117,COG0451@1,COG0451@2	NA|NA|NA	M	Male sterility protein
MAG.T21.41_01793	330214.NIDE4168	0.0	1201.8	Nitrospirae	kefB			ko:K03455					ko00000	2.A.37			Bacteria	3J0Y7@40117,COG0475@1,COG0475@2,COG0490@1,COG0490@2,COG1226@1,COG1226@2	NA|NA|NA	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MAG.T21.41_01794	330214.NIDE4167	9.3e-195	686.0	Bacteria													Bacteria	COG4638@1,COG4638@2	NA|NA|NA	P	Rieske (2fe-2S)
MAG.T21.41_01795	330214.NIDE4166	5.7e-89	333.6	Bacteria	cdr			ko:K04085	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	COG2210@1,COG2210@2	NA|NA|NA	P	Belongs to the sulfur carrier protein TusA family
MAG.T21.41_01796	330214.NIDE4165	9.8e-36	155.6	Nitrospirae			1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1C1@40117,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
MAG.T21.41_01797	330214.NIDE4164	3.4e-230	804.3	Bacteria	ftcD		2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100		R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147				Bacteria	COG3404@1,COG3404@2,COG3643@1,COG3643@2	NA|NA|NA	E	Formiminotransferase domain
MAG.T21.41_01798	330214.NIDE4163	3.4e-23	113.6	Bacteria	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904		ko:K02970	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	COG0828@1,COG0828@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bS21 family
MAG.T21.41_01799	330214.NIDE4162	1.8e-108	398.7	Nitrospirae	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0K6@40117,COG0177@1,COG0177@2	NA|NA|NA	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MAG.T21.41_01800	330214.NIDE4161	9.5e-63	246.1	Bacteria													Bacteria	COG2210@1,COG2210@2	NA|NA|NA	P	Belongs to the sulfur carrier protein TusA family
MAG.T21.41_01802	631454.N177_3158	1e-187	663.3	Rhodobiaceae													Bacteria	1JQN9@119043,1MWP2@1224,2TTRU@28211,COG1574@1,COG1574@2	NA|NA|NA	S	Amidohydrolase family
MAG.T21.41_01803	1380391.JIAS01000011_gene4843	1.8e-50	206.1	Rhodospirillales			2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	1MY47@1224,2JSSG@204441,2VEYT@28211,COG0625@1,COG0625@2	NA|NA|NA	O	Glutathione S-transferase, N-terminal domain
MAG.T21.41_01805	323261.Noc_1277	1.1e-185	656.4	Chromatiales													Bacteria	1MU48@1224,1RMBN@1236,1WXV4@135613,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_01806	330214.NIDE3158	6.2e-42	177.9	Bacteria				ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	COG0725@1,COG0725@2	NA|NA|NA	P	tungstate binding
MAG.T21.41_01807	330214.NIDE2965	2.8e-159	568.2	Nitrospirae	mexF			ko:K18299,ko:K18902,ko:K19585		M00641,M00698,M00767			ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.16,2.A.6.2.47			Bacteria	3J0FA@40117,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_01808	215803.DB30_3861	1.3e-38	166.4	Myxococcales				ko:K07484					ko00000				Bacteria	1RE5Q@1224,2WRPQ@28221,2YYMZ@29,42WSA@68525,COG2433@1,COG2433@2	NA|NA|NA	S	Transposase IS66 family
MAG.T21.41_01809	1123508.JH636446_gene6205	1.6e-43	183.3	Planctomycetes				ko:K07484					ko00000				Bacteria	2IYQC@203682,COG2433@1,COG2433@2	NA|NA|NA	S	Transposase IS66 family
MAG.T21.41_01810	1231392.OCGS_1555	1.3e-20	105.1	Alphaproteobacteria													Bacteria	1MWXX@1224,28I18@1,2TVHK@28211,2Z85X@2	NA|NA|NA		
MAG.T21.41_01813	330214.NIDE0317	1.1e-64	253.1	Bacteria	mug	GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.28,6.3.3.2	ko:K01934,ko:K03649	ko00670,ko01100,ko03410,map00670,map01100,map03410		R02301	RC00183	ko00000,ko00001,ko01000,ko03400				Bacteria	COG3663@1,COG3663@2	NA|NA|NA	L	G/U mismatch-specific uracil-DNA glycosylase activity
MAG.T21.41_01815	330214.NIDE0319	1.6e-83	315.5	Nitrospirae	nudF		3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610	Bacteria	3J0TN@40117,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T21.41_01816	330214.NIDE0320	1.3e-175	622.5	Nitrospirae	gcvT		2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000				Bacteria	3J11R@40117,COG0404@1,COG0404@2	NA|NA|NA	H	Aminomethyltransferase folate-binding domain
MAG.T21.41_01817	330214.NIDE0321	3e-52	211.1	Bacteria	fkpA		5.2.1.8	ko:K01802,ko:K03772					ko00000,ko01000,ko03110				Bacteria	COG0545@1,COG0545@2	NA|NA|NA	O	Peptidyl-prolyl cis-trans isomerase
MAG.T21.41_01818	330214.NIDE0322	7.2e-180	636.7	Bacteria		GO:0008150,GO:0040007											Bacteria	COG4398@1,COG4398@2	NA|NA|NA	E	FIST C domain
MAG.T21.41_01820	330214.NIDE0324	1.6e-185	655.6	Bacteria	dmpA		3.4.11.19	ko:K01266					ko00000,ko01000,ko01002				Bacteria	COG3191@1,COG3191@2	NA|NA|NA	EQ	aminopeptidase activity
MAG.T21.41_01821	330214.NIDE0325	1.4e-251	875.2	Nitrospirae				ko:K07576					ko00000				Bacteria	3J0FD@40117,COG1236@1,COG1236@2	NA|NA|NA	J	Beta-Casp domain
MAG.T21.41_01822	330214.NIDE0326	2.3e-140	505.0	Nitrospirae			3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	3J169@40117,COG1611@1,COG1611@2	NA|NA|NA	S	Possible lysine decarboxylase
MAG.T21.41_01825	330214.NIDE0329	5.8e-62	243.8	Bacteria													Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_01826	330214.NIDE0330	3.1e-102	377.9	Nitrospirae													Bacteria	3J0R2@40117,COG2928@1,COG2928@2	NA|NA|NA	S	Protein of unknown function (DUF502)
MAG.T21.41_01827	330214.NIDE0331	7.7e-31	139.4	Bacteria				ko:K09791					ko00000				Bacteria	COG2835@1,COG2835@2	NA|NA|NA	EG	tetraacyldisaccharide 4'-kinase activity
MAG.T21.41_01833	1122132.AQYH01000008_gene2768	3.3e-109	401.7	Rhizobiaceae			3.5.3.11,3.5.3.17	ko:K01480,ko:K18459	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVFH@1224,2TQSZ@28211,4B7AY@82115,COG0010@1,COG0010@2	NA|NA|NA	E	Belongs to the arginase family
MAG.T21.41_01834	1121033.AUCF01000001_gene2120	2e-49	203.0	Rhodospirillales	gcvA	GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03566	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1MWY0@1224,2JQUN@204441,2TSD9@28211,COG0583@1,COG0583@2	NA|NA|NA	K	LysR substrate binding domain
MAG.T21.41_01835	1297569.MESS2_1480046	3.4e-67	262.3	Phyllobacteriaceae	potD			ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1			Bacteria	1MUYW@1224,2TS7M@28211,43HDJ@69277,COG0687@1,COG0687@2	NA|NA|NA	E	Bacterial extracellular solute-binding protein
MAG.T21.41_01836	13690.CP98_03029	1.4e-184	652.1	Sphingomonadales	gap		1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	1MU93@1224,2K0GC@204457,2TR6E@28211,COG0057@1,COG0057@2	NA|NA|NA	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MAG.T21.41_01837	13690.CP98_03028	3.6e-48	197.2	Alphaproteobacteria													Bacteria	1NGEW@1224,2UJFN@28211,COG1396@1,COG1396@2	NA|NA|NA	K	TRANSCRIPTIONal
MAG.T21.41_01838	13690.CP98_03027	3.2e-162	577.8	Sphingomonadales				ko:K07112					ko00000				Bacteria	1NADV@1224,2K6PV@204457,2UGU0@28211,COG2391@1,COG2391@2	NA|NA|NA	S	Sulphur transport
MAG.T21.41_01839	571.MC52_30605	2.2e-48	198.7	Gammaproteobacteria				ko:K03712					ko00000,ko03000				Bacteria	1N74D@1224,1SYAK@1236,COG1846@1,COG1846@2	NA|NA|NA	K	MarR family
MAG.T21.41_01841	13690.CP98_03026	7.1e-156	556.6	Alphaproteobacteria													Bacteria	1R550@1224,2U4SA@28211,COG0583@1,COG0583@2	NA|NA|NA	K	LysR substrate binding domain
MAG.T21.41_01844	670307.HYPDE_23078	1.4e-62	246.9	Proteobacteria				ko:K10873	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1QWK7@1224,COG5055@1,COG5055@2	NA|NA|NA	L	Protein of unknown function (DUF968)
MAG.T21.41_01845	1161401.ASJA01000008_gene1633	2.6e-14	85.5	Alphaproteobacteria													Bacteria	1N7GN@1224,2EB3S@1,2UH2G@28211,3354G@2	NA|NA|NA	S	Siphovirus Gp157
MAG.T21.41_01846	366602.Caul_0335	7.2e-10	69.7	Caulobacterales													Bacteria	1Q1U5@1224,2KJ6I@204458,2V62J@28211,COG1396@1,COG1396@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_01848	309807.SRU_1660	7.1e-12	76.6	Bacteroidetes Order II. Incertae sedis													Bacteria	1FK1Q@1100069,4NNYV@976,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
MAG.T21.41_01850	622637.KE124774_gene2808	1.9e-35	156.4	Methylocystaceae													Bacteria	1N5Z8@1224,2UDGZ@28211,3701S@31993,COG0589@1,COG0589@2	NA|NA|NA	T	Universal stress protein family
MAG.T21.41_01852	330214.NIDE1479	2e-116	425.2	Bacteria													Bacteria	COG3000@1,COG3000@2	NA|NA|NA	I	iron ion binding
MAG.T21.41_01853	330214.NIDE1480	4.6e-138	497.7	Nitrospirae	dpm1		2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	3J16X@40117,COG0463@1,COG0463@2,COG2246@1,COG2246@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T21.41_01854	330214.NIDE1481	1.4e-186	659.4	Bacteria													Bacteria	COG4993@1,COG4993@2	NA|NA|NA	G	Dehydrogenase
MAG.T21.41_01855	330214.NIDE1482	6.7e-191	673.3	Bacteria	mltC	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044462,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08306,ko:K08308,ko:K08309					ko00000,ko01000,ko01011		GH23	iAF1260.b1193,iB21_1397.B21_01178,iBWG_1329.BWG_1018,iECBD_1354.ECBD_2429,iECB_1328.ECB_01168,iECDH10B_1368.ECDH10B_1246,iECDH1ME8569_1439.ECDH1ME8569_1132,iECD_1391.ECD_01168,iEcDH1_1363.EcDH1_2455,iEcolC_1368.EcolC_2432,iG2583_1286.G2583_3622,iJO1366.b1193,iUMNK88_1353.UMNK88_1507,iUMNK88_1353.UMNK88_3661,iY75_1357.Y75_RS06225	Bacteria	COG0741@1,COG0741@2	NA|NA|NA	M	lytic transglycosylase activity
MAG.T21.41_01856	330214.NIDE1483	1.5e-59	236.1	Bacteria	ttg2D			ko:K07323	ko02010,map02010	M00210			ko00000,ko00001,ko00002,ko02000	3.A.1.27.3			Bacteria	COG2854@1,COG2854@2	NA|NA|NA	Q	intermembrane phospholipid transfer
MAG.T21.41_01857	330214.NIDE1484	9.4e-39	167.2	Bacteria	narP			ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472			ko00000,ko00001,ko00002,ko02022				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_01859	330214.NIDE1487	5e-27	127.5	Bacteria													Bacteria	COG0784@1,COG0784@2	NA|NA|NA	T	Response regulator, receiver
MAG.T21.41_01861	330214.NIDE1489	5e-95	354.0	Nitrospirae	vsrD2			ko:K02282,ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475			ko00000,ko00001,ko00002,ko02022,ko02035,ko02044				Bacteria	3J12Q@40117,COG2197@1,COG2197@2	NA|NA|NA	K	Product type r regulator
MAG.T21.41_01862	330214.NIDE1491	9.2e-282	976.1	Nitrospirae	exsG		2.7.13.3	ko:K07675	ko02020,map02020	M00473			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J12P@40117,COG0745@1,COG0745@2,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2,COG5002@1,COG5002@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_01863	1242864.D187_002317	4e-54	217.6	Myxococcales	rcp1			ko:K02485,ko:K11355	ko02020,map02020	M00510			ko00000,ko00001,ko00002,ko02022				Bacteria	1QUN7@1224,2WS98@28221,2YV93@29,42VIG@68525,COG0784@1,COG0784@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T21.41_01864	330214.NIDE1493	1.2e-226	792.7	Nitrospirae													Bacteria	3J0Y3@40117,COG4251@1,COG4251@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_01865	330214.NIDE1494	7.7e-49	199.9	Bacteria	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112		ko:K15034					ko00000,ko03012				Bacteria	COG1186@1,COG1186@2	NA|NA|NA	J	translation release factor activity
MAG.T21.41_01866	330214.NIDE1495	3e-37	161.0	Bacteria	rbpA												Bacteria	COG0724@1,COG0724@2	NA|NA|NA	K	RNA recognition motif
MAG.T21.41_01867	330214.NIDE1497	7.7e-168	596.3	Bacteria	desC		1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212		R02222	RC00917	ko00000,ko00001,ko01000,ko01004				Bacteria	COG1398@1,COG1398@2	NA|NA|NA	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
MAG.T21.41_01870	330214.NIDE1500	2.5e-156	558.1	Nitrospirae	lpxL		2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0SH@40117,COG1560@1,COG1560@2	NA|NA|NA	M	Bacterial lipid A biosynthesis acyltransferase
MAG.T21.41_01873	330214.NIDE1503	3.1e-110	404.8	Nitrospirae				ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J0P4@40117,COG0767@1,COG0767@2	NA|NA|NA	Q	Permease MlaE
MAG.T21.41_01874	330214.NIDE1504	3.7e-86	324.7	Bacteria	ttg2A			ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	COG1127@1,COG1127@2	NA|NA|NA	Q	ATPase activity
MAG.T21.41_01875	330214.NIDE1505	9.3e-93	347.1	Nitrospirae	ycf22			ko:K02067	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J0VP@40117,COG1463@1,COG1463@2	NA|NA|NA	Q	MlaD protein
MAG.T21.41_01877	330214.NIDE1508	6.6e-159	566.6	Nitrospirae	gspE2			ko:K02652					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	3J0XR@40117,COG2203@1,COG2203@2,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II/IV secretion system protein
MAG.T21.41_01880	330214.NIDE4398	2.1e-46	191.4	Nitrospirae				ko:K06039,ko:K07235	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	3J1AA@40117,COG1553@1,COG1553@2	NA|NA|NA	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MAG.T21.41_01881	330214.NIDE4397	1.9e-215	755.0	Nitrospirae	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	Bacteria	3J0EC@40117,COG0124@1,COG0124@2	NA|NA|NA	J	Histidyl-tRNA synthetase
MAG.T21.41_01882	330214.NIDE4396	1e-260	905.6	Bacteria	thyX		2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100		R06613	RC00022,RC00332	ko00000,ko00001,ko01000				Bacteria	COG1351@1,COG1351@2	NA|NA|NA	F	thymidylate synthase (FAD) activity
MAG.T21.41_01883	330214.NIDE4395	1.6e-55	223.4	Nitrospirae													Bacteria	3J1CG@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_01886	330214.NIDE4390	2.9e-54	217.6	Nitrospirae				ko:K04752					ko00000				Bacteria	3J17N@40117,COG0347@1,COG0347@2	NA|NA|NA	K	Evidence 2b Function of strongly homologous gene
MAG.T21.41_01887	330214.NIDE4388	0.0	1915.2	Nitrospirae				ko:K09822					ko00000				Bacteria	3J0VY@40117,COG3002@1,COG3002@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2309)
MAG.T21.41_01888	330214.NIDE4387	4.9e-166	590.9	Bacteria	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	COG1008@1,COG1008@2	NA|NA|NA	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_01889	330214.NIDE4386	1.7e-288	998.0	Nitrospirae	nuoL2		1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0AN@40117,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-quinone oxidoreductase
MAG.T21.41_01890	330214.NIDE4385	4.9e-55	220.3	Nitrospirae	yrhF												Bacteria	3J180@40117,COG5609@1,COG5609@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2294)
MAG.T21.41_01891	330214.NIDE4384	5.4e-262	909.8	Bacteria	ydiU			ko:K08997					ko00000				Bacteria	COG0397@1,COG0397@2	NA|NA|NA	S	Uncharacterized ACR, YdiU/UPF0061 family
MAG.T21.41_01894	1321781.HMPREF1985_01945	2e-92	346.3	Firmicutes													Bacteria	1V4WG@1239,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyltransferase, group 1 family protein
MAG.T21.41_01895	330214.NIDE2989	1.6e-115	422.9	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01896	330214.NIDE2990	6.3e-95	354.0	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_01897	330214.NIDE2991	2e-159	568.9	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01898	330214.NIDE2992	2.9e-87	328.6	Bacteria	cypM_1		2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2227@1,COG2227@2	NA|NA|NA	H	3-demethylubiquinone-9 3-O-methyltransferase activity
MAG.T21.41_01899	330214.NIDE2993	1e-197	696.0	Nitrospirae													Bacteria	3J0X1@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferase, group 1
MAG.T21.41_01900	925409.KI911562_gene150	1.6e-71	276.6	Bacteroidetes													Bacteria	4NNQC@976,COG2227@1,COG2227@2	NA|NA|NA	H	Methyltransferase domain
MAG.T21.41_01901	330214.NIDE2995	1.9e-299	1034.6	Nitrospirae			6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	3J0XS@40117,COG0367@1,COG0367@2	NA|NA|NA	F	Asparagine synthase
MAG.T21.41_01902	330214.NIDE2996	3.3e-217	761.1	Nitrospirae													Bacteria	3J0ZX@40117,COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01903	330214.NIDE2997	3.9e-179	634.0	Bacteria			5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0451@1,COG0451@2	NA|NA|NA	GM	ADP-glyceromanno-heptose 6-epimerase activity
MAG.T21.41_01904	330214.NIDE2998	8.9e-196	689.5	Nitrospirae	neuC	GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016787,GO:0016798,GO:0044238,GO:0071704,GO:1901576	3.2.1.184,5.1.3.14	ko:K01791,ko:K18429	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R10187	RC00005,RC00288,RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0Y8@40117,COG0381@1,COG0381@2	NA|NA|NA	M	UDP-N-acetylglucosamine 2-epimerase
MAG.T21.41_01905	330214.NIDE2999	2.1e-191	674.9	Nitrospirae	neuB		2.5.1.56,3.2.1.183	ko:K01654,ko:K08068	ko00520,ko01100,map00520,map01100		R01804,R04435	RC00159	ko00000,ko00001,ko01000				Bacteria	3J0XF@40117,COG2089@1,COG2089@2	NA|NA|NA	M	SAF
MAG.T21.41_01906	330214.NIDE3000	1.2e-99	369.4	Nitrospirae	neuA		2.7.7.43,2.7.7.92	ko:K00983,ko:K21749	ko00520,ko01100,map00520,map01100		R01117,R04215	RC00152	ko00000,ko00001,ko01000				Bacteria	3J12Z@40117,COG1083@1,COG1083@2	NA|NA|NA	H	Cytidylyltransferase
MAG.T21.41_01908	1173264.KI913949_gene1853	2.6e-06	60.1	Oscillatoriales													Bacteria	1FZXE@1117,1H927@1150,COG3321@1,COG3321@2	NA|NA|NA	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.
MAG.T21.41_01909	289376.THEYE_A0478	1.4e-91	343.6	Nitrospirae													Bacteria	3J18P@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_01910	289376.THEYE_A0473	1.2e-117	429.9	Bacteria			5.1.3.10,5.1.3.2	ko:K01784,ko:K12454	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984,R04266	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0451@1,COG0451@2	NA|NA|NA	GM	ADP-glyceromanno-heptose 6-epimerase activity
MAG.T21.41_01911	330214.NIDE3007	2.4e-190	671.8	Nitrospirae													Bacteria	3J0XB@40117,COG2244@1,COG2244@2	NA|NA|NA	S	Polysaccharide biosynthesis protein
MAG.T21.41_01912	330214.NIDE3008	1.7e-83	315.5	Nitrospirae	cysC	GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564	1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4	ko:K00390,ko:K00860,ko:K00955,ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R02021,R04928,R04929	RC00002,RC00007,RC00078,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	3J141@40117,COG0529@1,COG0529@2	NA|NA|NA	F	Catalyzes the synthesis of activated sulfate
MAG.T21.41_01913	330214.NIDE3009	2.1e-259	901.7	Bacteria													Bacteria	COG5360@1,COG5360@2	NA|NA|NA	S	Heparinase II/III-like protein
MAG.T21.41_01914	330214.NIDE3010	0.0	1095.1	Bacteria			6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002				Bacteria	COG0367@1,COG0367@2	NA|NA|NA	E	asparagine synthase
MAG.T21.41_01915	330214.NIDE3011	1.4e-151	542.3	Nitrospirae	fcl		1.1.1.271	ko:K02377,ko:K16554	ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111		R05692	RC01014	ko00000,ko00001,ko01000,ko02000	8.A.3.1			Bacteria	3J0XH@40117,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
MAG.T21.41_01916	1502724.FF80_03107	1.5e-56	226.1	Alphaproteobacteria													Bacteria	1MVDK@1224,2TS7B@28211,COG3039@1,COG3039@2	NA|NA|NA	L	Transposase
MAG.T21.41_01917	316058.RPB_3163	6.8e-48	199.1	Bacteria													Bacteria	COG3266@1,COG3266@2	NA|NA|NA	GM	domain, Protein
MAG.T21.41_01919	330214.NIDE4290	1.3e-56	225.7	Bacteria	yidB												Bacteria	COG3753@1,COG3753@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF937)
MAG.T21.41_01922	330214.NIDE4293	3.7e-227	793.9	Nitrospirae	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007			iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158	Bacteria	3J0B3@40117,COG0001@1,COG0001@2	NA|NA|NA	H	Aminotransferase class-III
MAG.T21.41_01924	330214.NIDE4295	1.4e-94	352.4	Bacteria													Bacteria	COG1525@1,COG1525@2	NA|NA|NA	L	nuclease
MAG.T21.41_01925	589865.DaAHT2_2594	1.1e-117	429.5	Deltaproteobacteria													Bacteria	1RKCP@1224,2B22M@1,2WX4F@28221,31UJI@2,4321G@68525	NA|NA|NA	L	Restriction endonuclease
MAG.T21.41_01926	748247.AZKH_1177	6.1e-39	167.9	Betaproteobacteria													Bacteria	1N4MH@1224,2D2IW@1,2W1UY@28216,32TCX@2	NA|NA|NA	S	Protein of unknown function (DUF1353)
MAG.T21.41_01928	330214.NIDE2745	1.4e-230	805.4	Nitrospirae	hemA	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492	ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000,ko02035				Bacteria	3J0BD@40117,COG0373@1,COG0373@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MAG.T21.41_01929	330214.NIDE2746	4.5e-138	497.3	Nitrospirae													Bacteria	3J14H@40117,COG0755@1,COG0755@2	NA|NA|NA	O	Cytochrome C assembly protein
MAG.T21.41_01930	330214.NIDE2747	5.5e-69	267.7	Nitrospirae	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056					ko00000,ko01000,ko03009				Bacteria	3J0PU@40117,COG0313@1,COG0313@2	NA|NA|NA	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MAG.T21.41_01931	330214.NIDE2748	4.3e-34	150.6	Nitrospirae	tusA		1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1DD@40117,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
MAG.T21.41_01933	635013.TherJR_1675	8.1e-96	357.8	Clostridia	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464		ko:K06942					ko00000,ko03009				Bacteria	1UIBA@1239,24DM9@186801,COG0012@1,COG0012@2	NA|NA|NA	J	GTP binding
MAG.T21.41_01934	379066.GAU_3509	1.7e-22	111.3	Gemmatimonadetes	MA20_45435												Bacteria	1ZV5D@142182,COG1484@1,COG1484@2	NA|NA|NA	L	Bacterial dnaA  protein
MAG.T21.41_01935	1298858.AUEL01000011_gene5441	1.4e-120	439.5	Phyllobacteriaceae				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1MX7D@1224,2TRYA@28211,43JGK@69277,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T21.41_01936	176299.Atu2056	4.4e-49	200.7	Rhizobiaceae													Bacteria	1RD2I@1224,2U7MW@28211,4BE9I@82115,COG2128@1,COG2128@2	NA|NA|NA	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAG.T21.41_01937	1105367.CG50_06125	2.1e-57	228.8	Alphaproteobacteria	rfbC		5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000				Bacteria	1R9YD@1224,2U7G8@28211,COG1898@1,COG1898@2	NA|NA|NA	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
MAG.T21.41_01938	1434929.X946_5057	7.6e-110	405.2	Proteobacteria													Bacteria	1RJY9@1224,COG0438@1,COG0438@2,COG1216@1,COG1216@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_01939	1123247.AUIJ01000002_gene2191	1.8e-102	379.4	Alphaproteobacteria													Bacteria	1MUP0@1224,2TT57@28211,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase
MAG.T21.41_01940	672.VV93_v1c02950	4.5e-91	341.7	Gammaproteobacteria			2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000				Bacteria	1R7DD@1224,1RMEY@1236,COG0027@1,COG0027@2	NA|NA|NA	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MAG.T21.41_01941	319003.Bra1253DRAFT_08493	2.4e-129	468.8	Bradyrhizobiaceae	vioA	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308,ko:K20429	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUPN@1224,2TRIQ@28211,3JZJB@41294,COG0399@1,COG0399@2	NA|NA|NA	E	DegT/DnrJ/EryC1/StrS aminotransferase family
MAG.T21.41_01942	319003.Bra1253DRAFT_08490	4.9e-140	504.6	Bacteria				ko:K00754					ko00000,ko01000		GT4		Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_01943	1307437.J139_00530	2.9e-09	69.7	Pseudoalteromonadaceae													Bacteria	1RJKQ@1224,1S87E@1236,2C0XC@1,2Q2X6@267888,32R7R@2	NA|NA|NA		
MAG.T21.41_01944	1265502.KB905929_gene2204	2.7e-20	106.3	Betaproteobacteria													Bacteria	1REI6@1224,2W3JP@28216,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase, family 2
MAG.T21.41_01945	1122614.JHZF01000014_gene2584	9.8e-25	120.9	Bacteria	cdsA		2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	COG4589@1,COG4589@2	NA|NA|NA	S	phosphatidate cytidylyltransferase activity
MAG.T21.41_01946	1541065.JRFE01000028_gene3397	3.1e-54	218.8	Pleurocapsales													Bacteria	1G3UI@1117,3VJ17@52604,COG1028@1,COG1028@2	NA|NA|NA	IQ	PFAM short chain dehydrogenase
MAG.T21.41_01947	391619.PGA1_c23420	1.5e-32	146.7	Phaeobacter			2.1.1.172	ko:K00564,ko:K16710			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	1QV7D@1224,2TWCC@28211,34G26@302485,COG0463@1,COG0463@2,COG2327@1,COG2327@2,COG2813@1,COG2813@2	NA|NA|NA	JM	Specifically methylates the guanine in position
MAG.T21.41_01948	398527.Bphyt_4717	4e-27	129.8	Burkholderiaceae	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000			iSFV_1184.SFV_2325	Bacteria	1K8SD@119060,1NN5V@1224,2VWHM@28216,COG0223@1,COG0223@2	NA|NA|NA	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAG.T21.41_01950	1205680.CAKO01000039_gene443	2.1e-10	72.0	Alphaproteobacteria													Bacteria	1NEIK@1224,2EF80@1,2UGV5@28211,3390Z@2	NA|NA|NA		
MAG.T21.41_01951	311403.Arad_7549	2.7e-82	312.8	Rhizobiaceae			4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	1MV1V@1224,2TRTY@28211,4BB46@82115,COG2114@1,COG2114@2	NA|NA|NA	T	Adenylyl- / guanylyl cyclase, catalytic domain
MAG.T21.41_01952	1429916.X566_16690	2.2e-31	141.7	Bradyrhizobiaceae													Bacteria	1NEIK@1224,2EF80@1,2UGV5@28211,3390Z@2,3K5W9@41294	NA|NA|NA		
MAG.T21.41_01953	1205680.CAKO01000039_gene444	5.5e-26	123.2	Rhodospirillales	helA			ko:K15726					ko00000,ko02000	2.A.6.1.2			Bacteria	1NUIV@1224,2JR77@204441,2TRWM@28211,COG3696@1,COG3696@2	NA|NA|NA	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_01954	330214.NIDE1800	2.8e-108	398.3	Bacteria	potC			ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	COG1177@1,COG1177@2	NA|NA|NA	P	DNA import into cell involved in transformation
MAG.T21.41_01955	330214.NIDE1799	9.8e-126	456.4	Bacteria	potB			ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	COG1176@1,COG1176@2	NA|NA|NA	P	putrescine transport
MAG.T21.41_01956	330214.NIDE1798	1.4e-164	585.9	Bacteria	potA		3.6.3.31	ko:K11072	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1			Bacteria	COG3842@1,COG3842@2	NA|NA|NA	P	ATPase activity
MAG.T21.41_01960	330214.NIDE2558	3.7e-92	344.4	Nitrospirae	pgsA		2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100		R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000			iIT341.HP1016	Bacteria	3J0NH@40117,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T21.41_01961	330214.NIDE2557	2.7e-159	568.2	Nitrospirae	kdsD	GO:0003674,GO:0003824,GO:0016853,GO:0016860,GO:0016861,GO:0019146	5.3.1.13	ko:K03281,ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	2.A.49		iAF987.Gmet_1278	Bacteria	3J0GG@40117,COG0517@1,COG0517@2,COG0794@1,COG0794@2	NA|NA|NA	M	Belongs to the SIS family. GutQ KpsF subfamily
MAG.T21.41_01962	330214.NIDE2556	4.8e-143	513.8	Nitrospirae	kdsA		2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0AK@40117,COG2877@1,COG2877@2	NA|NA|NA	M	DAHP synthetase I family
MAG.T21.41_01963	330214.NIDE2555	1.9e-305	1054.3	Nitrospirae	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377	Bacteria	3J0FB@40117,COG0504@1,COG0504@2	NA|NA|NA	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MAG.T21.41_01964	330214.NIDE2554	1.6e-124	452.2	Nitrospirae	kdsB		2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0NR@40117,COG1212@1,COG1212@2	NA|NA|NA	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MAG.T21.41_01965	330214.NIDE2553	5.3e-165	587.0	Nitrospirae	rfaE		2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0GT@40117,COG2870@1,COG2870@2	NA|NA|NA	M	Phosphomethylpyrimidine kinase
MAG.T21.41_01966	330214.NIDE2552	2.8e-132	478.0	Nitrospirae			3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0IP@40117,COG0681@1,COG0681@2	NA|NA|NA	U	Signal peptidase, peptidase S26
MAG.T21.41_01967	330214.NIDE2551	0.0	1139.4	Nitrospirae	lepA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K03596	ko05134,map05134				ko00000,ko00001				Bacteria	3J0D1@40117,COG0481@1,COG0481@2	NA|NA|NA	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MAG.T21.41_01968	330214.NIDE2550	2.1e-209	734.9	Nitrospirae	bioA		2.6.1.105,2.6.1.62	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231,R10699	RC00006,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007			iSB619.SA_RS12705	Bacteria	3J0D9@40117,COG0161@1,COG0161@2	NA|NA|NA	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
MAG.T21.41_01970	330214.NIDE2548	7.1e-161	573.5	Bacteria				ko:K15727					ko00000,ko02000	8.A.1.2.1			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_01971	330214.NIDE2547	5.3e-126	457.2	Nitrospirae				ko:K22205					ko00000,ko01000				Bacteria	3J0RG@40117,COG1912@1,COG1912@2	NA|NA|NA	S	S-adenosyl-l-methionine hydroxide adenosyltransferase
MAG.T21.41_01972	330214.NIDE2546	1.5e-77	295.4	Nitrospirae	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Bacteria	3J0NA@40117,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MAG.T21.41_01973	330214.NIDE2545	1.2e-195	689.1	Nitrospirae	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	Bacteria	3J0BC@40117,COG0458@1,COG0458@2	NA|NA|NA	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
MAG.T21.41_01974	224914.BMEII0451	1.8e-191	675.2	Alphaproteobacteria	hsdM		2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	1MW3A@1224,2TQQA@28211,COG0286@1,COG0286@2	NA|NA|NA	V	Type I restriction-modification system methyltransferase subunit
MAG.T21.41_01975	330214.NIDE3913	2.9e-58	231.1	Bacteria													Bacteria	COG1807@1,COG1807@2	NA|NA|NA	M	4-amino-4-deoxy-L-arabinose transferase activity
MAG.T21.41_01977	330214.NIDE3912	4.8e-70	270.4	Bacteria													Bacteria	COG4244@1,COG4244@2	NA|NA|NA	E	Membrane
MAG.T21.41_01978	330214.NIDE3911	6.7e-21	107.1	Bacteria													Bacteria	COG1664@1,COG1664@2	NA|NA|NA	M	Polymer-forming cytoskeletal
MAG.T21.41_01982	888050.HMPREF9004_0872	2.1e-55	222.2	Actinobacteria	porC		1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2IJIZ@201174,4D5MR@85005,COG1014@1,COG1014@2	NA|NA|NA	C	2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family
MAG.T21.41_01984	330214.NIDE2209	8e-228	796.2	Nitrospirae	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0293,iYO844.BSU13130	Bacteria	3J0ET@40117,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAG.T21.41_01985	330214.NIDE2192	7.8e-76	290.4	Bacteria				ko:K07238					ko00000,ko02000	2.A.5.5			Bacteria	COG0428@1,COG0428@2	NA|NA|NA	P	transporter
MAG.T21.41_01986	330214.NIDE2190	4e-28	131.0	Bacteria													Bacteria	COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_01987	330214.NIDE2189	2.1e-67	262.7	Bacteria				ko:K03832					ko00000,ko02000	2.C.1.1			Bacteria	COG0810@1,COG0810@2	NA|NA|NA	M	energy transducer activity
MAG.T21.41_01988	330214.NIDE2188	1.7e-72	278.9	Bacteria				ko:K03088,ko:K07165					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_01989	330214.NIDE2185	2.4e-93	349.0	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_01990	330214.NIDE2183	0.0	1458.0	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_01991	330214.NIDE2180	4e-70	271.2	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_01992	330214.NIDE2179	4.9e-72	277.7	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_01993	330214.NIDE2178	0.0	1566.2	Bacteria	fecA			ko:K16091					ko00000,ko02000	1.B.14.1.14			Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_01994	330214.NIDE2177	2.3e-178	631.7	Bacteria													Bacteria	COG3182@1,COG3182@2	NA|NA|NA	E	Iron-regulated membrane protein
MAG.T21.41_01995	330214.NIDE2176	5.9e-56	223.8	Nitrospirae	fur	GO:0000976,GO:0001067,GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K03711					ko00000,ko03000				Bacteria	3J0UN@40117,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T21.41_01996	330214.NIDE2175	1.6e-73	282.3	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_01997	330214.NIDE2174	1.8e-112	412.5	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_01998	330214.NIDE2173	0.0	1394.0	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_01999	1038859.AXAU01000001_gene2709	4.5e-20	104.0	Proteobacteria	yrhH												Bacteria	1N2R0@1224,COG0500@1,COG2226@2	NA|NA|NA	Q	COG0500 SAM-dependent methyltransferases
MAG.T21.41_02000	1449049.JONW01000009_gene4291	1.6e-33	149.4	Alphaproteobacteria													Bacteria	1P4M5@1224,2TSQV@28211,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator, araC family
MAG.T21.41_02001	1305735.JAFT01000005_gene873	1.2e-37	162.5	Alphaproteobacteria	ychN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0034214,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0065003,GO:0071840		ko:K06039					ko00000				Bacteria	1RDFR@1224,2U9F0@28211,COG1553@1,COG1553@2	NA|NA|NA	P	DsrE/DsrF-like family
MAG.T21.41_02002	1040986.ATYO01000012_gene5284	3.3e-138	498.0	Phyllobacteriaceae													Bacteria	1R2KY@1224,2TR2U@28211,43NSP@69277,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T21.41_02003	330214.NIDE4042	4.4e-58	230.7	Nitrospirae				ko:K09825					ko00000,ko03000				Bacteria	3J1CV@40117,COG0735@1,COG0735@2	NA|NA|NA	L	Ferric uptake regulator family
MAG.T21.41_02004	330214.NIDE4041	1.3e-75	288.9	Nitrospirae	rbr												Bacteria	3J0RY@40117,COG1592@1,COG1592@2	NA|NA|NA	C	Rubrerythrin
MAG.T21.41_02005	330214.NIDE4040	4.2e-210	737.3	Bacteria	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3,1.2.7.3	ko:K00113,ko:K00176,ko:K05524,ko:K13795,ko:K13796	ko00020,ko00564,ko00720,ko01100,ko01110,ko01120,ko01200,map00020,map00564,map00720,map01100,map01110,map01120,map01200	M00009,M00011,M00173,M00620	R00848,R01197	RC00004,RC00029,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0247@1,COG0247@2,COG1146@1,COG1146@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
MAG.T21.41_02006	234267.Acid_5736	1.8e-06	60.8	Bacteria													Bacteria	COG3012@1,COG3012@2	NA|NA|NA		
MAG.T21.41_02008	330214.NIDE1927	2.2e-136	491.9	Nitrospirae	mntH			ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3			Bacteria	3J1A7@40117,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
MAG.T21.41_02009	330214.NIDE1926	9.1e-53	213.0	Bacteria	amcY	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_02010	330214.NIDE1925	1.8e-76	292.0	Nitrospirae													Bacteria	3J1E9@40117,COG0589@1,COG0589@2	NA|NA|NA	T	Universal stress protein family
MAG.T21.41_02012	330214.NIDE1923	2.3e-87	328.6	Bacteria		GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K07100					ko00000				Bacteria	COG1073@1,COG1073@2	NA|NA|NA	S	thiolester hydrolase activity
MAG.T21.41_02013	330214.NIDE1922	7e-129	466.8	Bacteria													Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_02015	330214.NIDE1920	7.4e-210	736.5	Nitrospirae	yqeV	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707			R10649	RC00003,RC03221	ko00000,ko01000,ko03016				Bacteria	3J112@40117,COG0621@1,COG0621@2	NA|NA|NA	J	Uncharacterized protein family UPF0004
MAG.T21.41_02016	330214.NIDE1919	5.7e-242	843.2	Nitrospirae	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Bacteria	3J0GE@40117,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAG.T21.41_02019	1317124.DW2_13720	6.4e-75	287.0	Thioclava	virB6			ko:K03201	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1QJY1@1224,2TSZ1@28211,2XM3N@285107,COG3704@1,COG3704@2	NA|NA|NA	U	Conjugal transfer protein
MAG.T21.41_02020	195105.CN97_11390	1.1e-119	436.0	Alphaproteobacteria													Bacteria	1R7GW@1224,2U0K7@28211,COG1359@1,COG1359@2	NA|NA|NA	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MAG.T21.41_02021	195105.CN97_11395	3.6e-149	534.3	Alphaproteobacteria													Bacteria	1R51E@1224,2TZIK@28211,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_02022	330214.NIDE4351	1.6e-106	392.5	Bacteria	suhB2		3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0483@1,COG0483@2	NA|NA|NA	G	inositol monophosphate 1-phosphatase activity
MAG.T21.41_02023	330214.NIDE3045	1.7e-117	428.7	Nitrospirae	galU		2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0B2@40117,COG1210@1,COG1210@2	NA|NA|NA	M	Nucleotidyl transferase
MAG.T21.41_02024	330214.NIDE3046	0.0	1474.1	Nitrospirae	lon		3.4.21.53	ko:K01338	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0DQ@40117,COG0466@1,COG0466@2	NA|NA|NA	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MAG.T21.41_02025	330214.NIDE3047	1.4e-145	522.7	Nitrospirae	thiL		2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iYO844.BSU05900	Bacteria	3J0TF@40117,COG0611@1,COG0611@2	NA|NA|NA	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MAG.T21.41_02026	330214.NIDE3048	6.8e-73	280.0	Nitrospirae				ko:K09928					ko00000				Bacteria	3J1DC@40117,COG3216@1,COG3216@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2062)
MAG.T21.41_02027	330214.NIDE3049	6.3e-260	902.9	Nitrospirae				ko:K06885					ko00000				Bacteria	3J0YB@40117,COG1078@1,COG1078@2	NA|NA|NA	S	Metal dependent phosphohydrolases with conserved 'HD' motif.
MAG.T21.41_02028	330214.NIDE3050	0.0	1248.8	Bacteria			3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4251@1,COG4251@2	NA|NA|NA	T	Pas domain
MAG.T21.41_02029	298653.Franean1_6521	1.1e-34	152.9	Actinobacteria													Bacteria	2I2VM@201174,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulator receiver
MAG.T21.41_02030	330214.NIDE3052	0.0	1197.2	Nitrospirae	MA20_35885												Bacteria	3J10H@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02031	330214.NIDE3053	6.3e-158	563.5	Nitrospirae			3.4.24.75	ko:K08259					ko00000,ko01000,ko01002,ko01011				Bacteria	3J16B@40117,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase family M23
MAG.T21.41_02032	330214.NIDE3054	1.3e-262	911.8	Bacteria	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	COG0638@1,COG0638@2	NA|NA|NA	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAG.T21.41_02033	330214.NIDE3055	2.9e-117	427.9	Bacteria			3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	COG0638@1,COG0638@2	NA|NA|NA	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAG.T21.41_02034	330214.NIDE3056	2e-118	431.8	Bacteria	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	COG0638@1,COG0638@2	NA|NA|NA	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAG.T21.41_02035	330214.NIDE3057	1.9e-270	937.9	Bacteria	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	COG4122@1,COG4122@2	NA|NA|NA	E	O-methyltransferase activity
MAG.T21.41_02036	330214.NIDE3058	4e-306	1056.6	Bacteria	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369		ko:K13527	ko03050,map03050	M00342			ko00000,ko00001,ko00002,ko03051				Bacteria	COG1222@1,COG1222@2	NA|NA|NA	O	protein catabolic process
MAG.T21.41_02037	330214.NIDE3059	9.8e-64	250.0	Nitrospirae	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0QS@40117,COG0352@1,COG0352@2	NA|NA|NA	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MAG.T21.41_02038	330214.NIDE3060	1.8e-136	491.9	Nitrospirae	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100		R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000				Bacteria	3J0EI@40117,COG2022@1,COG2022@2	NA|NA|NA	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MAG.T21.41_02039	330214.NIDE3061	7.2e-24	115.9	Nitrospirae	thiS			ko:K03154	ko04122,map04122				ko00000,ko00001				Bacteria	3J1CM@40117,COG2104@1,COG2104@2	NA|NA|NA	H	ThiS family
MAG.T21.41_02040	330214.NIDE2460	1.5e-44	185.3	Nitrospirae	nth		4.2.99.18	ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0K6@40117,COG0177@1,COG0177@2	NA|NA|NA	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MAG.T21.41_02041	330214.NIDE2461	1.2e-131	476.1	Nitrospirae	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575											Bacteria	3J0QJ@40117,COG1561@1,COG1561@2	NA|NA|NA	S	Domain of unknown function (DUF1732)
MAG.T21.41_02042	330214.NIDE2462	7.7e-113	413.3	Nitrospirae	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Bacteria	3J0JT@40117,COG0194@1,COG0194@2	NA|NA|NA	F	Essential for recycling GMP and indirectly, cGMP
MAG.T21.41_02043	330214.NIDE2463	1e-49	202.6	Nitrospirae	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	3J0UJ@40117,COG1758@1,COG1758@2	NA|NA|NA	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MAG.T21.41_02044	330214.NIDE2464	1.9e-191	675.2	Nitrospirae	coaBC		4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0GK@40117,COG0452@1,COG0452@2	NA|NA|NA	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MAG.T21.41_02045	330214.NIDE2465	7.3e-52	210.7	Bacteria			2.7.11.1	ko:K14949,ko:K20543	ko05152,map05152				ko00000,ko00001,ko01000,ko01001,ko02000	1.B.55.3			Bacteria	COG3118@1,COG3118@2	NA|NA|NA	O	belongs to the thioredoxin family
MAG.T21.41_02046	330214.NIDE2466	7.5e-75	286.6	Nitrospirae	aroQ		4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000			iIT341.HP1038	Bacteria	3J199@40117,COG0757@1,COG0757@2	NA|NA|NA	E	Catalyzes a trans-dehydration via an enolate intermediate
MAG.T21.41_02047	330214.NIDE2467	1.9e-98	365.2	Nitrospirae	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125		ko:K02356					ko00000,ko03012				Bacteria	3J0JC@40117,COG0231@1,COG0231@2	NA|NA|NA	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MAG.T21.41_02048	330214.NIDE2468	8.6e-68	263.1	Nitrospirae	accB		2.3.1.12,4.1.1.3,6.4.1.1	ko:K00627,ko:K01571,ko:K01960,ko:K02160	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00307,M00376,M00620	R00209,R00217,R00344,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1			Bacteria	3J0PI@40117,COG0511@1,COG0511@2	NA|NA|NA	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MAG.T21.41_02049	330214.NIDE2469	3.9e-251	873.6	Nitrospirae	accC		6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0AJ@40117,COG0439@1,COG0439@2	NA|NA|NA	I	Biotin carboxylase C-terminal domain
MAG.T21.41_02050	330214.NIDE2470	4.9e-70	270.8	Nitrospirae	thiE	GO:0000287,GO:0003674,GO:0003824,GO:0004789,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00788,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_4300,iSSON_1240.SSON_4166	Bacteria	3J0ND@40117,COG0352@1,COG0352@2	NA|NA|NA	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MAG.T21.41_02051	330214.NIDE2471	3.2e-74	285.0	Nitrospirae	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0SI@40117,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MAG.T21.41_02052	1356854.N007_03220	2.9e-32	145.6	Alicyclobacillaceae													Bacteria	1TP76@1239,279C6@186823,4HAA6@91061,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T21.41_02053	330214.NIDE2474	1.7e-141	508.8	Bacteria													Bacteria	2DGGU@1,2ZVXA@2	NA|NA|NA		
MAG.T21.41_02054	330214.NIDE2475	0.0	1597.8	Bacteria	rocA		1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130		R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000			iAF987.Gmet_3512,iYO844.BSU37780	Bacteria	COG0506@1,COG0506@2,COG1012@1,COG1012@2	NA|NA|NA	E	proline dehydrogenase activity
MAG.T21.41_02055	330214.NIDE1715	1.6e-153	550.4	Bacteria													Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
MAG.T21.41_02058	330214.NIDE0888	1e-114	419.5	Bacteria	wzi												Bacteria	COG3170@1,COG3170@2	NA|NA|NA	NU	translation initiation factor activity
MAG.T21.41_02059	330214.NIDE0889	0.0	1369.8	Bacteria	kpsD			ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Bacteria	COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export
MAG.T21.41_02060	330214.NIDE0890	3.1e-162	578.2	Bacteria			3.1.21.3	ko:K01153,ko:K05789,ko:K07011,ko:K16554	ko05111,map05111				ko00000,ko00001,ko01000,ko01005,ko02000,ko02048	8.A.3.1			Bacteria	COG3206@1,COG3206@2	NA|NA|NA	M	extracellular polysaccharide biosynthetic process
MAG.T21.41_02061	330214.NIDE0891	7.4e-194	682.9	Nitrospirae	hpnH												Bacteria	3J0X6@40117,COG0535@1,COG0535@2	NA|NA|NA	S	Domain of unknown function (DUF3463)
MAG.T21.41_02062	330214.NIDE0892	2.6e-54	218.0	Bacteria													Bacteria	29E6W@1,3014W@2	NA|NA|NA		
MAG.T21.41_02064	330214.NIDE0895	4.8e-77	293.9	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02065	330214.NIDE0896	0.0	1104.4	Bacteria			1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6			Bacteria	COG1271@1,COG1271@2	NA|NA|NA	C	aerobic electron transport chain
MAG.T21.41_02066	330214.NIDE0897	5.7e-141	506.9	Bacteria				ko:K17052					ko00000,ko02000	5.A.3.8			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02067	330214.NIDE0898	3.6e-163	580.9	Bacteria			1.3.5.1,1.3.5.4	ko:K00240,ko:K03886	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00151,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0723@1,COG0723@2	NA|NA|NA	C	oxidoreductase activity, acting on diphenols and related substances as donors
MAG.T21.41_02068	330214.NIDE0899	2.3e-212	744.6	Nitrospirae				ko:K00412,ko:K03887	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152			ko00000,ko00001,ko00002,ko03029				Bacteria	3J0Q6@40117,COG1290@1,COG1290@2	NA|NA|NA	C	Cytochrome b/b6/petB
MAG.T21.41_02070	330214.NIDE0901	0.0	1127.9	Bacteria			1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6			Bacteria	COG1271@1,COG1271@2	NA|NA|NA	C	aerobic electron transport chain
MAG.T21.41_02071	330214.NIDE0902	3.3e-96	357.8	Bacteria	soxD			ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02072	330214.NIDE0903	2.7e-129	468.0	Bacteria													Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02073	330214.NIDE0904	6.1e-146	523.5	Bacteria													Bacteria	2ERPD@1,33J8R@2	NA|NA|NA	S	Ethylbenzene dehydrogenase
MAG.T21.41_02074	330214.NIDE0905	3e-163	581.3	Bacteria				ko:K02305,ko:K07152	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko03029	3.D.4.10			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02075	330214.NIDE0906	1.4e-101	376.3	Nitrospirae	ubiA	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006			iZ_1308.Z5639	Bacteria	3J0TY@40117,COG0382@1,COG0382@2	NA|NA|NA	H	UbiA prenyltransferase family
MAG.T21.41_02076	330214.NIDE0907	2.1e-210	738.8	Nitrospirae													Bacteria	3J0QX@40117,COG4249@1,COG4249@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_02077	1205680.CAKO01000006_gene3328	2e-09	70.5	Alphaproteobacteria													Bacteria	1NHW6@1224,2UK9W@28211,COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_02079	1288494.EBAPG3_9990	6.7e-95	354.0	Nitrosomonadales				ko:K07497					ko00000				Bacteria	1MVXQ@1224,2VHER@28216,372VZ@32003,COG2801@1,COG2801@2	NA|NA|NA	L	PFAM Integrase, catalytic
MAG.T21.41_02081	89187.ISM_03520	2.4e-52	211.5	Alphaproteobacteria	epsN		2.6.1.102	ko:K13010,ko:K19430	ko00520,map00520		R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007				Bacteria	1MUPN@1224,2TVTA@28211,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_02084	107635.AZUO01000001_gene3473	4.7e-33	149.1	Alphaproteobacteria													Bacteria	1RD7S@1224,2VGXY@28211,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_02085	1121013.P873_02535	3.9e-10	72.0	Bacteria				ko:K05801					ko00000,ko03110				Bacteria	COG0484@1,COG0484@2	NA|NA|NA	O	heat shock protein binding
MAG.T21.41_02086	1384054.N790_08115	7.1e-141	507.7	Xanthomonadales	ywqD		2.7.10.1	ko:K08252,ko:K13661,ko:K16554	ko05111,map05111				ko00000,ko00001,ko01000,ko02000	8.A.3.1			Bacteria	1MVI9@1224,1RNB0@1236,1XCG4@135614,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	D	G-rich domain on putative tyrosine kinase
MAG.T21.41_02087	330214.NIDE3308	1e-137	496.1	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_02088	330214.NIDE3309	5.2e-89	335.1	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_02089	584708.Apau_0800	1.1e-08	67.0	Synergistetes				ko:K03598					ko00000,ko03021				Bacteria	3TBN5@508458,COG3026@1,COG3026@2	NA|NA|NA	T	antisigma factor binding
MAG.T21.41_02090	330214.NIDE3311	2.7e-153	548.1	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_02091	330214.NIDE3313	0.0	1325.1	Bacteria			1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_02092	330214.NIDE2493	1.4e-221	775.4	Nitrospirae		GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007		ko:K06990					ko00000,ko04812				Bacteria	3J0U4@40117,COG1355@1,COG1355@2	NA|NA|NA	S	Memo-like protein
MAG.T21.41_02093	330214.NIDE2492	1.5e-130	472.2	Bacteria													Bacteria	2ANS9@1,31DS7@2	NA|NA|NA		
MAG.T21.41_02094	330214.NIDE2491	1.6e-61	241.9	Bacteria													Bacteria	28MYQ@1,2ZB5K@2	NA|NA|NA		
MAG.T21.41_02095	330214.NIDE2162	6.5e-115	420.6	Bacteria	pvdI												Bacteria	COG1020@1,COG1020@2	NA|NA|NA	Q	D-alanine [D-alanyl carrier protein] ligase activity
MAG.T21.41_02096	118163.Ple7327_2770	2e-19	101.7	Cyanobacteria													Bacteria	1G620@1117,COG5485@1,COG5485@2	NA|NA|NA	S	PFAM SnoaL-like polyketide cyclase
MAG.T21.41_02097	1190606.AJYG01000173_gene520	8.3e-33	147.1	Vibrionales	cpt			ko:K18554					br01600,ko00000,ko01000,ko01504				Bacteria	1NEN0@1224,1STA5@1236,1XXNZ@135623,COG3896@1,COG3896@2	NA|NA|NA	V	Chloramphenicol phosphotransferase-like protein
MAG.T21.41_02098	330214.NIDE2163	0.0	1638.2	Bacteria				ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2			Bacteria	COG0841@1,COG0841@2	NA|NA|NA	V	transmembrane transporter activity
MAG.T21.41_02099	330214.NIDE2164	6.7e-161	573.5	Bacteria	mdtA_2			ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_02101	330214.NIDE2166	9.2e-75	287.3	Bacteria				ko:K03832					ko00000,ko02000	2.C.1.1			Bacteria	COG0810@1,COG0810@2	NA|NA|NA	M	energy transducer activity
MAG.T21.41_02102	330214.NIDE2167	2.1e-53	214.9	Bacteria	exbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03559					ko00000,ko02000	1.A.30.2.1			Bacteria	COG0848@1,COG0848@2	NA|NA|NA	U	biopolymer transport protein
MAG.T21.41_02103	330214.NIDE2168	3.9e-60	237.7	Bacteria	exbB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03561,ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.1,1.A.30.2.2			Bacteria	COG0811@1,COG0811@2	NA|NA|NA	U	bacteriocin transport
MAG.T21.41_02105	330214.NIDE2169	4.7e-304	1050.0	Bacteria													Bacteria	COG1506@1,COG1506@2	NA|NA|NA	E	serine-type peptidase activity
MAG.T21.41_02106	518766.Rmar_0400	3.6e-81	308.9	Bacteroidetes Order II. Incertae sedis	enpP		3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1FJY0@1100069,4NFFG@976,COG1524@1,COG1524@2	NA|NA|NA	S	Type I phosphodiesterase / nucleotide pyrophosphatase
MAG.T21.41_02107	330214.NIDE2170	1e-63	249.6	Bacteria	yrkC												Bacteria	COG0662@1,COG0662@2	NA|NA|NA	G	Cupin 2, conserved barrel domain protein
MAG.T21.41_02108	517417.Cpar_1703	3.1e-12	77.4	Bacteria				ko:K07172,ko:K18842					ko00000,ko02048				Bacteria	COG2336@1,COG2336@2	NA|NA|NA	T	PFAM SpoVT AbrB
MAG.T21.41_02109	404589.Anae109_2801	2.6e-25	121.7	Deltaproteobacteria	doc			ko:K07341					ko00000,ko02048				Bacteria	1N1FW@1224,2WR7E@28221,42V74@68525,COG3654@1,COG3654@2	NA|NA|NA	S	Fic/DOC family
MAG.T21.41_02110	351160.RCIX1144	1.4e-61	242.7	Euryarchaeota			1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Archaea	2XYCY@28890,COG0450@1,arCOG00312@2157	NA|NA|NA	O	AhpC/TSA family
MAG.T21.41_02112	330214.NIDE0758	5.2e-190	670.2	Nitrospirae	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502		R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146		iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Bacteria	3J0C4@40117,COG0472@1,COG0472@2	NA|NA|NA	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAG.T21.41_02113	330214.NIDE0757	7.5e-240	836.3	Nitrospirae	murF		6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502		R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	3J0PW@40117,COG0770@1,COG0770@2	NA|NA|NA	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MAG.T21.41_02114	330214.NIDE0756	1.3e-226	792.3	Nitrospirae	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.10,6.3.2.13,6.3.2.7	ko:K01928,ko:K05362,ko:K15792	ko00300,ko00550,ko01100,map00300,map00550,map01100		R02786,R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	3J0DS@40117,COG0769@1,COG0769@2	NA|NA|NA	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MAG.T21.41_02117	330214.NIDE0738	7.3e-194	683.3	Nitrospirae			2.4.1.83	ko:K00721,ko:K20534	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003,ko01005,ko02000	4.D.2.1.9	GT2		Bacteria	3J13V@40117,COG0463@1,COG0463@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T21.41_02118	330214.NIDE0737	7.1e-149	533.5	Bacteria				ko:K07027					ko00000,ko02000	4.D.2			Bacteria	COG0392@1,COG0392@2	NA|NA|NA	M	lysyltransferase activity
MAG.T21.41_02119	330214.NIDE0736	5.5e-227	793.5	Bacteria			2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100		R11025	RC00002	ko00000,ko00001,ko01000				Bacteria	COG0558@1,COG0558@2,COG1208@1,COG1208@2	NA|NA|NA	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MAG.T21.41_02120	330214.NIDE0735	3.9e-125	454.1	Nitrospirae			2.7.7.74,5.4.2.9	ko:K01841,ko:K07281	ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130		R00661,R09669	RC00002,RC02792	ko00000,ko00001,ko01000				Bacteria	3J1BZ@40117,COG1213@1,COG1213@2	NA|NA|NA	M	Nucleotidyl transferase
MAG.T21.41_02121	330214.NIDE0734	5.5e-179	633.6	Nitrospirae	phnW	GO:0003674,GO:0003824	2.5.1.49,2.6.1.37,3.11.1.1	ko:K01740,ko:K03430,ko:K05306,ko:K09469	ko00270,ko00440,ko01100,ko01120,map00270,map00440,map01100,map01120		R00747,R01287,R04152,R04859	RC00008,RC00020,RC00062,RC00368,RC02821,RC02848	ko00000,ko00001,ko01000,ko01007				Bacteria	3J0FC@40117,COG0075@1,COG0075@2	NA|NA|NA	E	Evidence 2b Function of strongly homologous gene
MAG.T21.41_02122	330214.NIDE0733	2e-95	355.1	Bacteria			4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130		R04053	RC00506	ko00000,ko00001,ko01000				Bacteria	COG0028@1,COG0028@2	NA|NA|NA	EH	Belongs to the TPP enzyme family
MAG.T21.41_02123	330214.NIDE0732	1.1e-81	309.3	Bacteria	ppd		4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130		R04053	RC00506	ko00000,ko00001,ko01000				Bacteria	COG4032@1,COG4032@2	NA|NA|NA	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MAG.T21.41_02126	330214.NIDE0728	5.7e-99	367.1	Nitrospirae	acrR												Bacteria	3J1CN@40117,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T21.41_02127	330214.NIDE0727	2.7e-195	688.0	Nitrospirae				ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6			Bacteria	3J15F@40117,COG0845@1,COG0845@2	NA|NA|NA	M	HlyD family secretion protein
MAG.T21.41_02128	330214.NIDE0726	0.0	1876.7	Nitrospirae													Bacteria	3J0ZG@40117,COG0841@1,COG0841@2	NA|NA|NA	V	AcrB/AcrD/AcrF family
MAG.T21.41_02129	330214.NIDE0725	1.6e-47	195.3	Bacteria													Bacteria	COG3255@1,COG3255@2	NA|NA|NA	I	Sterol carrier protein
MAG.T21.41_02130	330214.NIDE0724	3.2e-77	294.3	Bacteria	speD		2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1586@1,COG1586@2	NA|NA|NA	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MAG.T21.41_02131	2340.JV46_15240	1.7e-67	262.3	unclassified Gammaproteobacteria	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K13288	ko03008,map03008				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1J5R2@118884,1R9WX@1224,1S217@1236,COG1949@1,COG1949@2	NA|NA|NA	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MAG.T21.41_02132	1033802.SSPSH_002752	7.1e-33	147.9	Gammaproteobacteria													Bacteria	1NZ1M@1224,1S7A2@1236,COG5281@1,COG5281@2	NA|NA|NA	D	sister chromatid segregation
MAG.T21.41_02134	1122197.ATWI01000008_gene2680	1.9e-33	149.8	Alteromonadaceae													Bacteria	1NZ1M@1224,1S5IS@1236,46B06@72275,COG5281@1,COG5281@2	NA|NA|NA	D	sister chromatid segregation
MAG.T21.41_02137	330214.NIDE2352	1.2e-186	659.1	Nitrospirae	cheB		3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	3J0X3@40117,COG2201@1,COG2201@2	NA|NA|NA	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MAG.T21.41_02138	330214.NIDE2351	5.1e-168	597.0	Nitrospirae	cheV		2.7.13.3	ko:K03407,ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	3J14W@40117,COG0784@1,COG0784@2,COG0835@1,COG0835@2	NA|NA|NA	T	Two component signalling adaptor domain
MAG.T21.41_02139	330214.NIDE2350	2.7e-290	1004.2	Nitrospirae	cheA		2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	3J0BG@40117,COG0643@1,COG0643@2,COG2198@1,COG2198@2	NA|NA|NA	NT	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_02140	330214.NIDE2349	7.2e-94	350.1	Nitrospirae				ko:K03414	ko02030,map02030				ko00000,ko00001,ko02035				Bacteria	3J1AW@40117,COG3143@1,COG3143@2	NA|NA|NA	NT	Chemotaxis phosphatase, CheZ
MAG.T21.41_02141	330214.NIDE2348	1.4e-57	228.8	Nitrospirae													Bacteria	3J1FT@40117,COG0745@1,COG0745@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T21.41_02142	330214.NIDE2347	2.2e-151	541.6	Nitrospirae	cheR		2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko01000,ko02035				Bacteria	3J0XI@40117,COG1352@1,COG1352@2	NA|NA|NA	NT	Chemotaxis protein methyltransferase
MAG.T21.41_02143	330214.NIDE2346	4.9e-27	127.1	Bacteria				ko:K02806	ko02060,map02060				ko00000,ko00001,ko01000,ko02000				Bacteria	COG3311@1,COG3311@2	NA|NA|NA	K	DNA excision
MAG.T21.41_02144	330214.NIDE2345	1.3e-160	572.4	Bacteria	ylxH-3			ko:K04562					ko00000,ko02035				Bacteria	COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T21.41_02147	330214.NIDE3014	3.5e-136	491.1	Nitrospirae	rmlD		1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0SU@40117,COG1091@1,COG1091@2	NA|NA|NA	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MAG.T21.41_02148	330214.NIDE3015	2.8e-180	637.9	Nitrospirae	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3464	Bacteria	3J0CT@40117,COG1088@1,COG1088@2	NA|NA|NA	M	Male sterility protein
MAG.T21.41_02149	330214.NIDE3016	5.4e-130	470.3	Nitrospirae	spsI		2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KX@40117,COG1209@1,COG1209@2	NA|NA|NA	M	Nucleotidyl transferase
MAG.T21.41_02150	330214.NIDE3019	3.3e-160	571.2	Nitrospirae	wbdA2			ko:K00786					ko00000,ko01000				Bacteria	3J19R@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02151	330214.NIDE3020	2.3e-154	551.6	Nitrospirae													Bacteria	3J1DN@40117,COG1216@1,COG1216@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02152	330214.NIDE3021	5.4e-176	623.6	Bacteria	crtF												Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_02153	330214.NIDE3022	7.8e-155	553.1	Nitrospirae													Bacteria	3J1DN@40117,COG1216@1,COG1216@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02154	330214.NIDE3023	1.9e-47	194.9	Nitrospirae	rfaQ			ko:K02841,ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	3J161@40117,COG0859@1,COG0859@2	NA|NA|NA	M	Glycosyltransferase family 9 (heptosyltransferase)
MAG.T21.41_02155	292415.Tbd_1491	4.4e-276	957.2	Betaproteobacteria			2.1.1.72	ko:K00571,ko:K07316					ko00000,ko01000,ko02048				Bacteria	1MX9M@1224,2VGZB@28216,COG2189@1,COG2189@2	NA|NA|NA	L	PFAM DNA methylase N-4 N-6
MAG.T21.41_02158	330214.NIDE2620	4.5e-267	927.2	Nitrospirae	hsdR		3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	3J18J@40117,COG4096@1,COG4096@2	NA|NA|NA	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02160	330214.NIDE1220	9.4e-124	449.9	Nitrospirae	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100		R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036			iJN678.sll1005	Bacteria	3J0Q7@40117,COG1694@1,COG3956@2	NA|NA|NA	S	MazG nucleotide pyrophosphohydrolase domain
MAG.T21.41_02161	330214.NIDE1221	4e-53	214.2	Bacteria													Bacteria	2EAFJ@1,334IY@2	NA|NA|NA	S	Domain of unknown function (DUF1844)
MAG.T21.41_02166	247490.KSU1_C0781	7.6e-140	503.8	Bacteria													Bacteria	COG1404@1,COG1404@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T21.41_02167	247490.KSU1_C0782	3.3e-130	471.9	Planctomycetes													Bacteria	2J09P@203682,COG3319@1,COG3319@2	NA|NA|NA	Q	amino acid activation for nonribosomal peptide biosynthetic process
MAG.T21.41_02168	330214.NIDE2610	3.8e-214	750.7	Nitrospirae			1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3			Bacteria	3J0HH@40117,COG1271@1,COG1271@2	NA|NA|NA	C	Cytochrome bd terminal oxidase subunit I
MAG.T21.41_02170	330214.NIDE2760	4.2e-90	337.4	Nitrospirae	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02838					ko00000,ko03012				Bacteria	3J0KJ@40117,COG0233@1,COG0233@2	NA|NA|NA	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MAG.T21.41_02171	330214.NIDE2761	1.4e-156	559.3	Nitrospirae	alr		5.1.1.1,6.3.2.10	ko:K01775,ko:K01929	ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502		R00401,R04573,R04617	RC00064,RC00141,RC00285	ko00000,ko00001,ko01000,ko01011				Bacteria	3J0JH@40117,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAG.T21.41_02176	330214.NIDE2273	5.1e-60	236.9	Nitrospirae													Bacteria	294Y5@1,2ZSB2@2,3J1DZ@40117	NA|NA|NA		
MAG.T21.41_02178	330214.NIDE2271	5.5e-114	417.5	Bacteria													Bacteria	2E1AM@1,32QU2@2	NA|NA|NA		
MAG.T21.41_02183	330214.NIDE2267	9.8e-237	825.9	Nitrospirae	yfhA	GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07715	ko02020,ko02024,map02020,map02024	M00502			ko00000,ko00001,ko00002,ko02022				Bacteria	3J0ZU@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_02184	330214.NIDE2266	1.7e-84	319.3	Bacteria	yttA		2.7.13.3	ko:K07184,ko:K07777,ko:K12065,ko:K13527	ko02020,ko03050,map02020,map03050	M00342,M00478			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03051	3.A.7.11.1			Bacteria	COG2433@1,COG2433@2	NA|NA|NA		
MAG.T21.41_02185	330214.NIDE2265	9.2e-222	776.2	Nitrospirae			2.7.13.3	ko:K07651,ko:K07711	ko02020,ko02024,map02020,map02024	M00458,M00502			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J10G@40117,COG2770@1,COG2770@2,COG5002@1,COG5002@2	NA|NA|NA	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MAG.T21.41_02186	1408422.JHYF01000009_gene1958	3.8e-15	89.0	Clostridiaceae													Bacteria	1V1MY@1239,24H5K@186801,28PHB@1,2ZC7V@2,36IHD@31979	NA|NA|NA		
MAG.T21.41_02187	909613.UO65_0305	7.5e-13	80.5	Bacteria													Bacteria	2A5G6@1,30U67@2	NA|NA|NA		
MAG.T21.41_02189	349102.Rsph17025_0173	8.9e-48	196.1	Rhodobacter	hypE			ko:K04655,ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Bacteria	1FD40@1060,1RDJ4@1224,2U7HE@28211,COG0309@1,COG0309@2	NA|NA|NA	O	PFAM transposase, IS4 family protein
MAG.T21.41_02190	1301098.PKB_4406	3.3e-108	398.7	Gammaproteobacteria													Bacteria	1R6ZR@1224,1RRKI@1236,COG0457@1,COG0457@2	NA|NA|NA	S	Domain of unknown function (DUF4071)
MAG.T21.41_02191	331678.Cphamn1_2478	5.2e-60	238.4	Chlorobi													Bacteria	1FF06@1090,COG1073@1,COG1073@2	NA|NA|NA	S	Alpha/beta hydrolase family
MAG.T21.41_02192	323097.Nham_2535	6.1e-38	164.5	Bradyrhizobiaceae				ko:K07001,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	1MV7G@1224,2U1I4@28211,3JUCQ@41294,COG0664@1,COG0664@2	NA|NA|NA	K	Transcriptional regulator, Crp Fnr family
MAG.T21.41_02194	1088721.NSU_3023	1.1e-14	86.3	Bacteria													Bacteria	COG0697@1,COG0697@2	NA|NA|NA	EG	spore germination
MAG.T21.41_02196	398525.KB900701_gene4969	2.6e-97	361.7	Bradyrhizobiaceae													Bacteria	1MUBZ@1224,2TQZQ@28211,3JR2M@41294,COG2020@1,COG2020@2	NA|NA|NA	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family
MAG.T21.41_02199	288000.BBta_p0193	4e-72	278.1	Bradyrhizobiaceae													Bacteria	1R4WC@1224,29T2P@1,2U4MI@28211,30E96@2,3K31S@41294	NA|NA|NA	C	Class III cytochrome C family
MAG.T21.41_02200	288000.BBta_p0092	4.6e-59	234.6	Bradyrhizobiaceae													Bacteria	1RJA5@1224,293YE@1,2TUII@28211,2ZRDF@2,3JXV3@41294	NA|NA|NA		
MAG.T21.41_02201	288000.BBta_p0195	1.3e-157	563.5	Bradyrhizobiaceae	msrQ												Bacteria	1MY2Q@1224,2U0WY@28211,3JVZN@41294,COG1018@1,COG1018@2	NA|NA|NA	C	Oxidoreductase NAD-binding domain
MAG.T21.41_02202	196490.AUEZ01000014_gene2013	1.6e-17	96.7	Bradyrhizobiaceae													Bacteria	1R7P4@1224,2DNEG@1,2UCRV@28211,32X40@2,3JXAB@41294	NA|NA|NA	S	LTXXQ motif family protein
MAG.T21.41_02203	288000.BBta_p0180	8.2e-50	203.4	Bradyrhizobiaceae			1.12.7.2,1.12.99.6	ko:K00534,ko:K06282	ko00633,ko01120,map00633,map01120		R00019,R08034	RC00250	ko00000,ko00001,ko01000				Bacteria	1MWAC@1224,2TSVK@28211,3JT28@41294,COG1740@1,COG1740@2	NA|NA|NA	C	small subunit
MAG.T21.41_02204	1197906.CAJQ02000012_gene1105	1.3e-32	146.0	Bradyrhizobiaceae				ko:K03424					ko00000,ko01000				Bacteria	1R450@1224,2TUDR@28211,3K30Y@41294,COG0084@1,COG0084@2	NA|NA|NA	L	TatD related DNase
MAG.T21.41_02206	1282361.ABAC402_19225	9.3e-34	150.2	Alphaproteobacteria													Bacteria	1RDBN@1224,2VFA9@28211,COG3335@1,COG3335@2	NA|NA|NA	L	transposable element conserved
MAG.T21.41_02208	78245.Xaut_4598	5.7e-15	86.3	Xanthobacteraceae													Bacteria	1MUCX@1224,2TR59@28211,3EZ0C@335928,COG4372@1,COG4372@2	NA|NA|NA	S	Transposase C of IS166 homeodomain
MAG.T21.41_02211	1150469.RSPPHO_03094	4.1e-09	67.4	Rhodospirillales													Bacteria	1N8AN@1224,2JSP0@204441,2UA25@28211,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T21.41_02212	1096930.L284_01540	5.7e-122	444.1	Sphingomonadales	cadA		3.6.3.3,3.6.3.5	ko:K01534					ko00000,ko01000	3.A.3.6			Bacteria	1MU08@1224,2K0HI@204457,2TR56@28211,COG2217@1,COG2217@2	NA|NA|NA	P	cation transport ATPase
MAG.T21.41_02216	330214.NIDE3768	0.0	1162.5	Nitrospirae			2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	3J0Y2@40117,COG0296@1,COG0296@2	NA|NA|NA	G	Alpha amylase, catalytic domain
MAG.T21.41_02217	330214.NIDE3769	4.1e-71	274.2	Bacteria	cysC		2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0529@1,COG0529@2	NA|NA|NA	P	adenylylsulfate kinase activity
MAG.T21.41_02218	330214.NIDE3770	9.9e-189	666.0	Bacteria													Bacteria	COG3173@1,COG3173@2	NA|NA|NA	S	very-long-chain-acyl-CoA dehydrogenase activity
MAG.T21.41_02219	330214.NIDE3772	1e-85	322.8	Bacteria	raiA			ko:K03704,ko:K05809					ko00000,ko03000,ko03009				Bacteria	COG1278@1,COG1278@2,COG1544@1,COG1544@2	NA|NA|NA	J	regulation of translation
MAG.T21.41_02220	330214.NIDE3773	0.0	1468.4	Nitrospirae	ycbZ		3.4.21.53	ko:K01338,ko:K04076,ko:K04770	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0X2@40117,COG1067@1,COG1067@2	NA|NA|NA	O	AAA domain
MAG.T21.41_02222	330214.NIDE3775	3.5e-48	197.6	Nitrospirae				ko:K12263					ko00000				Bacteria	3J1AX@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02223	330214.NIDE3776	8.5e-70	270.0	Bacteria	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.11.1,3.5.1.19	ko:K08281,ko:K12132	ko00760,ko01100,map00760,map01100		R01268	RC00100	ko00000,ko00001,ko01000,ko01001			iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802	Bacteria	COG1335@1,COG1335@2	NA|NA|NA	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
MAG.T21.41_02224	330214.NIDE3777	7.9e-196	689.9	Bacteria	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100		R01724	RC00033	ko00000,ko00001,ko01000			iYO844.BSU31750	Bacteria	COG1488@1,COG1488@2	NA|NA|NA	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MAG.T21.41_02225	330214.NIDE3778	3.8e-26	126.3	Nitrospirae													Bacteria	3J1CA@40117,COG1357@1,COG1357@2	NA|NA|NA	S	Pentapeptide repeats (9 copies)
MAG.T21.41_02227	330214.NIDE3781	2.8e-162	578.2	Nitrospirae	yajR_1												Bacteria	3J0VR@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T21.41_02228	330214.NIDE3782	5.6e-66	256.9	Bacteria				ko:K07182					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_02229	330214.NIDE3783	3.1e-46	191.4	Bacteria				ko:K07182					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_02230	1249627.D779_0535	3.9e-08	65.1	Chromatiales													Bacteria	1N6V1@1224,1SETV@1236,1X14M@135613,2C5P4@1,3310H@2	NA|NA|NA		
MAG.T21.41_02231	330214.NIDE3785	2.4e-135	488.4	Bacteria													Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_02232	330214.NIDE3786	0.0	1540.0	Nitrospirae	pacL		3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978				ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2			Bacteria	3J0WH@40117,COG0474@1,COG0474@2	NA|NA|NA	P	Cation transporter/ATPase, N-terminus
MAG.T21.41_02233	330214.NIDE3787	3.6e-138	497.7	Bacteria				ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_02234	330214.NIDE3790	6.6e-115	420.2	Bacteria	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	COG0861@1,COG0861@2	NA|NA|NA	P	Integral membrane protein TerC family
MAG.T21.41_02235	345341.KUTG_00490	1.1e-55	224.6	Pseudonocardiales													Bacteria	2GJZH@201174,4EAUR@85010,COG5607@1,COG5607@2	NA|NA|NA	S	CYTH
MAG.T21.41_02237	1295642.H839_07284	1.8e-69	270.4	Geobacillus	phoD		3.1.3.1,3.1.4.46	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko01000				Bacteria	1UGF1@1239,1WG8A@129337,4H9QE@91061,COG0584@1,COG0584@2,COG3540@1,COG3540@2	NA|NA|NA	C	Glycerophosphoryl diester phosphodiesterase family
MAG.T21.41_02239	330214.NIDE3791	2.3e-126	458.4	Bacteria				ko:K16129	ko01054,map01054				ko00000,ko00001,ko01008				Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_02241	330214.NIDE3793	9.8e-256	889.0	Nitrospirae													Bacteria	29W26@1,30HKR@2,3J1BV@40117	NA|NA|NA		
MAG.T21.41_02242	330214.NIDE3794	8.3e-146	523.1	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_02243	330214.NIDE3796	1e-166	592.8	Nitrospirae			2.1.1.302	ko:K21377					ko00000,ko01000				Bacteria	3J1C8@40117,COG0500@1,COG2226@2	NA|NA|NA	H	Dimerisation domain
MAG.T21.41_02244	929703.KE386491_gene3992	1e-22	114.0	Cytophagia	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005			ic_1306.c0216	Bacteria	47RE1@768503,4NT1W@976,COG1044@1,COG1044@2	NA|NA|NA	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MAG.T21.41_02246	658187.LDG_7972	5e-15	88.2	Legionellales													Bacteria	1JG04@118969,1QC8C@1224,1T7XR@1236,2BVT5@1,347S4@2	NA|NA|NA		
MAG.T21.41_02247	330214.NIDE3799	3.2e-93	347.8	Bacteria													Bacteria	COG2249@1,COG2249@2	NA|NA|NA	K	NAD(P)H dehydrogenase (quinone) activity
MAG.T21.41_02249	330214.NIDE3803	1.6e-77	295.8	Bacteria	yjdF			ko:K08984					ko00000				Bacteria	COG3647@1,COG3647@2	NA|NA|NA	S	Membrane
MAG.T21.41_02250	330214.NIDE3804	3.3e-107	394.4	Bacteria				ko:K08984					ko00000				Bacteria	COG3647@1,COG3647@2	NA|NA|NA	S	Membrane
MAG.T21.41_02253	330214.NIDE3807	4.5e-111	407.5	Nitrospirae	sufC			ko:K09013					ko00000,ko02000				Bacteria	3J19D@40117,COG0396@1,COG0396@2	NA|NA|NA	O	ABC transporter
MAG.T21.41_02254	330214.NIDE3808	9.9e-145	519.6	Nitrospirae				ko:K07033					ko00000				Bacteria	3J1E6@40117,COG0719@1,COG0719@2	NA|NA|NA	O	Uncharacterized protein family (UPF0051)
MAG.T21.41_02257	330214.NIDE3809	5.1e-131	474.2	Bacteria	walW												Bacteria	COG0726@1,COG0726@2	NA|NA|NA	G	polysaccharide deacetylase
MAG.T21.41_02258	330214.NIDE3810	1.4e-164	585.9	Bacteria	celD												Bacteria	COG5653@1,COG5653@2	NA|NA|NA	M	Protein involved in cellulose biosynthesis
MAG.T21.41_02259	330214.NIDE3811	4.5e-230	803.9	Nitrospirae	epsH												Bacteria	3J156@40117,COG1269@1,COG1269@2	NA|NA|NA	C	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02260	330214.NIDE3812	2e-132	479.9	Nitrospirae													Bacteria	3J17M@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02261	330214.NIDE1877	3.8e-42	178.7	Bacteria													Bacteria	COG2931@1,COG2931@2	NA|NA|NA	Q	calcium- and calmodulin-responsive adenylate cyclase activity
MAG.T21.41_02262	330214.NIDE3813	4.9e-96	357.5	Bacteria													Bacteria	COG4625@1,COG4625@2	NA|NA|NA	T	pathogenesis
MAG.T21.41_02263	438753.AZC_2261	4.8e-113	414.5	Xanthobacteraceae	lspL		5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100		R01385	RC00289	ko00000,ko00001,ko01000				Bacteria	1MU7J@1224,2TSIP@28211,3EZ2G@335928,COG0451@1,COG0451@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
MAG.T21.41_02264	1121033.AUCF01000009_gene1196	2.7e-170	605.1	Rhodospirillales	wbpA		1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520		R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005				Bacteria	1MUC6@1224,2JPNX@204441,2TR5F@28211,COG0677@1,COG0677@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T21.41_02265	330214.NIDE4197	7.4e-17	92.4	Bacteria													Bacteria	COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase activity
MAG.T21.41_02268	330214.NIDE4200	1.9e-40	171.8	Bacteria													Bacteria	2DU53@1,33NYX@2	NA|NA|NA		
MAG.T21.41_02269	330214.NIDE4201	3.3e-88	331.3	Bacteria	sigE			ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_02272	330214.NIDE4204	1.4e-105	389.4	Bacteria	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051		R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003				Bacteria	COG3769@1,COG3769@2	NA|NA|NA	S	mannosylglycerate metabolic process
MAG.T21.41_02274	330214.NIDE4206	2.1e-118	431.8	Bacteria	cmpX												Bacteria	COG0668@1,COG0668@2	NA|NA|NA	M	transmembrane transport
MAG.T21.41_02275	330214.NIDE4207	4.9e-243	846.7	Bacteria			2.4.1.268	ko:K21349					ko00000,ko01000		GT81		Bacteria	COG0463@1,COG0463@2	NA|NA|NA	M	Glycosyl transferase, family 2
MAG.T21.41_02280	330214.NIDE4234	4.5e-108	397.5	Nitrospirae	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	Bacteria	3J0SC@40117,COG0284@1,COG0284@2	NA|NA|NA	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MAG.T21.41_02281	330214.NIDE4235	3.6e-34	150.6	Nitrospirae	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02968	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0TS@40117,COG0268@1,COG0268@2	NA|NA|NA	J	Binds directly to 16S ribosomal RNA
MAG.T21.41_02282	330214.NIDE4236	6.9e-169	600.1	Nitrospirae	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	3J1EC@40117,COG1466@1,COG1466@2	NA|NA|NA	L	DNA polymerase III, delta subunit
MAG.T21.41_02284	330214.NIDE4238	0.0	1573.9	Nitrospirae	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	3J0F8@40117,COG0495@1,COG0495@2	NA|NA|NA	J	Leucyl-tRNA synthetase, Domain 2
MAG.T21.41_02285	330214.NIDE4239	5e-90	337.4	Nitrospirae	pmtA												Bacteria	3J1DH@40117,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase domain
MAG.T21.41_02286	330214.NIDE1006	3.4e-185	654.4	Nitrospirae													Bacteria	3J19W@40117,COG3391@1,COG3391@2	NA|NA|NA	S	NHL repeat
MAG.T21.41_02287	330214.NIDE1005	2.9e-180	637.9	Nitrospirae	leuB	GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000			iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082	Bacteria	3J0JQ@40117,COG0473@1,COG0473@2	NA|NA|NA	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MAG.T21.41_02288	330214.NIDE1004	2.5e-51	208.0	Bacteria													Bacteria	COG0662@1,COG0662@2	NA|NA|NA	G	Cupin 2, conserved barrel domain protein
MAG.T21.41_02289	330214.NIDE1002	1.1e-276	958.7	Nitrospirae	leuA		2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS10690,iYO844.BSU28280	Bacteria	3J0F7@40117,COG0119@1,COG0119@2	NA|NA|NA	E	Belongs to the alpha-IPM synthase homocitrate synthase family
MAG.T21.41_02291	330214.NIDE1001	5.5e-122	443.7	Nitrospirae	pssA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KW@40117,COG1183@1,COG1183@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T21.41_02292	330214.NIDE1000	2e-112	411.8	Nitrospirae	psd		4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KD@40117,COG0688@1,COG0688@2	NA|NA|NA	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
MAG.T21.41_02293	330214.NIDE0999	1.9e-186	658.3	Nitrospirae	ilvC		1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS10005,iHN637.CLJU_RS10010,iJN746.PP_4678,iLJ478.TM0550	Bacteria	3J0DW@40117,COG0059@1,COG0059@2	NA|NA|NA	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MAG.T21.41_02294	330214.NIDE0998	1.9e-84	318.5	Nitrospirae	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086	Bacteria	3J0K8@40117,COG0440@1,COG0440@2	NA|NA|NA	E	ACT domain
MAG.T21.41_02295	330214.NIDE0997	0.0	1158.3	Nitrospirae	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082	Bacteria	3J0D6@40117,COG0028@1,COG0028@2	NA|NA|NA	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MAG.T21.41_02296	675635.Psed_5623	1.4e-07	62.4	Pseudonocardiales		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2IR0P@201174,4E5DS@85010,COG0695@1,COG0695@2	NA|NA|NA	O	PFAM Glutaredoxin-like domain (DUF836)
MAG.T21.41_02297	330214.NIDE0994	1.4e-131	475.7	Bacteria													Bacteria	COG1730@1,COG1730@2	NA|NA|NA	O	sister chromatid segregation
MAG.T21.41_02298	330214.NIDE0994	4e-38	163.7	Bacteria													Bacteria	COG1730@1,COG1730@2	NA|NA|NA	O	sister chromatid segregation
MAG.T21.41_02299	330214.NIDE0993	3.3e-137	494.6	Bacteria													Bacteria	COG0501@1,COG0501@2	NA|NA|NA	O	metalloendopeptidase activity
MAG.T21.41_02300	330214.NIDE0992	2.9e-106	391.3	Bacteria	rnhC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03471	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	COG1039@1,COG1039@2	NA|NA|NA	L	RNA-DNA hybrid ribonuclease activity
MAG.T21.41_02301	330214.NIDE0991	2.6e-85	322.0	Nitrospirae	CP_0228		3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0UV@40117,COG1579@1,COG1579@2	NA|NA|NA	S	C4-type zinc ribbon domain
MAG.T21.41_02303	330214.NIDE0990	4.2e-309	1066.6	Nitrospirae	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03086					ko00000,ko03021				Bacteria	3J0E4@40117,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T21.41_02304	330214.NIDE0989	3.5e-295	1020.4	Nitrospirae	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576		ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	3J0IN@40117,COG0358@1,COG0358@2	NA|NA|NA	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MAG.T21.41_02305	330214.NIDE0966	3.6e-106	391.0	Bacteria	fucA		2.2.1.8,4.1.2.17	ko:K01628,ko:K18847	ko00051,ko01120,map00051,map01120		R02262	RC00603,RC00604	ko00000,ko00001,ko01000				Bacteria	COG0235@1,COG0235@2	NA|NA|NA	G	Class ii aldolase
MAG.T21.41_02306	330214.NIDE0965	2e-140	505.4	Bacteria		GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704		ko:K07019					ko00000				Bacteria	COG0429@1,COG0429@2	NA|NA|NA	S	poly(3-hydroxybutyrate) depolymerase activity
MAG.T21.41_02307	330214.NIDE1586	6.8e-86	325.9	Bacteria			2.7.13.3	ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	Gaf domain
MAG.T21.41_02308	330214.NIDE0963	0.0	1345.1	Bacteria													Bacteria	COG0500@1,COG2226@2,COG2267@1,COG2267@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_02311	330214.NIDE0960	3.2e-265	920.6	Nitrospirae	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	3J0XW@40117,COG4122@1,COG4122@2	NA|NA|NA	S	Pup-ligase protein
MAG.T21.41_02312	330214.NIDE0959	4.3e-115	421.0	Nitrospirae	prcA		3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	3J15S@40117,COG0638@1,COG0638@2	NA|NA|NA	O	Proteasome subunit
MAG.T21.41_02313	330214.NIDE0958	3.3e-130	471.1	Nitrospirae	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	3J11F@40117,COG0638@1,COG0638@2	NA|NA|NA	O	Proteasome subunit
MAG.T21.41_02314	330214.NIDE0957	3.1e-24	117.1	Bacteria	ubact												Bacteria	2ERDX@1,33IZH@2	NA|NA|NA	S	May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes
MAG.T21.41_02315	330214.NIDE0956	6.5e-271	939.5	Nitrospirae	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	3J0ZW@40117,COG4122@1,COG4122@2	NA|NA|NA	S	Pup-ligase protein
MAG.T21.41_02316	330214.NIDE0955	1.1e-298	1031.9	Nitrospirae				ko:K13527	ko03050,map03050	M00342			ko00000,ko00001,ko00002,ko03051				Bacteria	3J0Z7@40117,COG1222@1,COG1222@2	NA|NA|NA	O	Proteasomal ATPase OB/ID domain
MAG.T21.41_02317	330214.NIDE0954	1e-164	586.3	Nitrospirae	degP		1.3.1.74	ko:K08070					ko00000,ko01000				Bacteria	3J0X9@40117,COG0265@1,COG0265@2	NA|NA|NA	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_02318	330214.NIDE0953	9.9e-60	236.1	Bacteria													Bacteria	COG0432@1,COG0432@2	NA|NA|NA	S	Uncharacterised protein family UPF0047
MAG.T21.41_02319	330214.NIDE0952	2.6e-131	474.9	Bacteria			3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000,ko02048				Bacteria	COG2206@1,COG2206@2	NA|NA|NA	T	PFAM metal-dependent phosphohydrolase, HD sub domain
MAG.T21.41_02321	330214.NIDE0950	1.2e-60	239.2	Bacteria													Bacteria	COG0537@1,COG0537@2	NA|NA|NA	FG	bis(5'-adenosyl)-triphosphatase activity
MAG.T21.41_02323	330214.NIDE0948	6.2e-124	451.1	Nitrospirae				ko:K02450,ko:K07126		M00331			ko00000,ko00002,ko02044	9.B.42			Bacteria	3J1CG@40117,COG0457@1,COG0457@2,COG0790@1,COG0790@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_02324	330214.NIDE0947	0.0	1220.3	Bacteria			3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021				Bacteria	COG3829@1,COG3829@2,COG4252@1,COG4252@2	NA|NA|NA	T	Chase2 domain
MAG.T21.41_02325	330214.NIDE0942	8.2e-103	380.2	Bacteria				ko:K03640					ko00000,ko02000	2.C.1.2			Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_02328	330214.NIDE2955	0.0	1650.2	Bacteria													Bacteria	2F5HV@1,33Y3B@2	NA|NA|NA	S	IgA Peptidase M64
MAG.T21.41_02329	330214.NIDE1591	5.7e-106	390.6	Nitrospirae				ko:K07502					ko00000				Bacteria	3J137@40117,COG3359@1,COG3359@2	NA|NA|NA	L	RNase_H superfamily
MAG.T21.41_02330	330214.NIDE1592	3.9e-61	240.7	Nitrospirae				ko:K09143					ko00000				Bacteria	3J181@40117,COG2164@1,COG2164@2	NA|NA|NA	S	Cyclophilin-like
MAG.T21.41_02331	330214.NIDE1593	1.2e-37	162.2	Nitrospirae				ko:K09804					ko00000				Bacteria	3J1ED@40117,COG2952@1,COG2952@2	NA|NA|NA	S	Protein of unknown function (DUF507)
MAG.T21.41_02332	330214.NIDE1594	4.9e-36	156.8	Nitrospirae				ko:K09804					ko00000				Bacteria	3J1DP@40117,COG2952@1,COG2952@2	NA|NA|NA	S	Protein of unknown function (DUF507)
MAG.T21.41_02333	330214.NIDE2087	6.8e-11	73.9	Bacteria													Bacteria	COG3063@1,COG3063@2	NA|NA|NA	NU	photosynthesis
MAG.T21.41_02334	330214.NIDE1596	5.6e-72	276.9	Nitrospirae	bcp		1.11.1.15,2.7.7.42,2.7.7.89	ko:K00982,ko:K03564					ko00000,ko01000				Bacteria	3J13P@40117,COG1225@1,COG1225@2	NA|NA|NA	O	AhpC/TSA family
MAG.T21.41_02337	330214.NIDE1599	1.1e-136	492.7	Nitrospirae	fabI	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J11E@40117,COG0623@1,COG0623@2	NA|NA|NA	I	Enoyl-(Acyl carrier protein) reductase
MAG.T21.41_02338	330214.NIDE1600	3.4e-98	365.5	Bacteria													Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
MAG.T21.41_02339	330214.NIDE1616	6.7e-249	866.3	Bacteria													Bacteria	2DM57@1,31S0Y@2	NA|NA|NA		
MAG.T21.41_02340	330214.NIDE1617	2.1e-224	784.6	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_02341	330214.NIDE1618	1.2e-183	649.0	Bacteria													Bacteria	COG1621@1,COG1621@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 32 family
MAG.T21.41_02343	330214.NIDE1620	1.1e-187	662.5	Bacteria	cysA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358	3.6.3.25,3.6.3.29	ko:K02017,ko:K02045,ko:K10112,ko:K16787	ko00920,ko02010,map00920,map02010	M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00582,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.1,3.A.1.6.3,3.A.1.8		iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511	Bacteria	COG1118@1,COG1118@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MAG.T21.41_02344	330214.NIDE1621	1.7e-129	468.8	Bacteria	cysW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02046,ko:K02047	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iPC815.YPO3013	Bacteria	COG4208@1,COG4208@2	NA|NA|NA	P	ATPase-coupled sulfate transmembrane transporter activity
MAG.T21.41_02345	330214.NIDE1622	3.8e-138	497.7	Bacteria	cysT			ko:K02018,ko:K02046	ko00920,ko02010,map00920,map02010	M00185,M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.8			Bacteria	COG0555@1,COG0555@2	NA|NA|NA	P	ATPase-coupled sulfate transmembrane transporter activity
MAG.T21.41_02346	330214.NIDE1623	7.5e-165	586.6	Bacteria	subI	GO:0005575,GO:0005623,GO:0042597,GO:0044464		ko:K02048	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iJN678.sbpA	Bacteria	COG1613@1,COG1613@2	NA|NA|NA	P	Sulfate ABC transporter periplasmic sulfate-binding protein
MAG.T21.41_02347	330214.NIDE1624	9.9e-71	272.7	Bacteria	cymR			ko:K13643					ko00000,ko03000				Bacteria	COG1959@1,COG1959@2	NA|NA|NA	K	2 iron, 2 sulfur cluster binding
MAG.T21.41_02350	330214.NIDE1631	4.5e-174	617.1	Nitrospirae	glyQ	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01878,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	Bacteria	3J0F5@40117,COG0752@1,COG0752@2	NA|NA|NA	J	Glycyl-tRNA synthetase alpha subunit
MAG.T21.41_02351	330214.NIDE1632	0.0	1246.5	Nitrospirae	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	Bacteria	3J0F0@40117,COG0751@1,COG0751@2	NA|NA|NA	J	Glycyl-tRNA synthetase beta subunit
MAG.T21.41_02352	330214.NIDE2729	2.7e-141	508.1	Bacteria			3.2.1.51	ko:K01206,ko:K07114,ko:K07126	ko00511,map00511				ko00000,ko00001,ko01000,ko02000,ko04147	1.A.13.2.2,1.A.13.2.3	GH29		Bacteria	COG1729@1,COG1729@2	NA|NA|NA	S	protein trimerization
MAG.T21.41_02353	330214.NIDE2728	1.1e-62	245.7	Nitrospirae	gcvH			ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002				Bacteria	3J0SD@40117,COG0509@1,COG0509@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
MAG.T21.41_02354	330214.NIDE2727	1.1e-238	832.4	Nitrospirae	lpdA		1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0IM@40117,COG1249@1,COG1249@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_02355	330214.NIDE2726	5.6e-39	167.5	Bacteria	comEA		2.4.1.21	ko:K00703,ko:K02237,ko:K02238	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00429,M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02044	3.A.11.1,3.A.11.2	GT5		Bacteria	COG1555@1,COG1555@2	NA|NA|NA	L	photosystem II stabilization
MAG.T21.41_02356	330214.NIDE2725	2.3e-202	711.4	Nitrospirae	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iJN746.PP_0436,iLJ478.TM0478	Bacteria	3J0FX@40117,COG0162@1,COG0162@2	NA|NA|NA	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MAG.T21.41_02358	330214.NIDE2724	1.3e-236	825.5	Bacteria				ko:K01993,ko:K16922					ko00000,ko01002				Bacteria	COG0845@1,COG0845@2,COG2203@1,COG2203@2	NA|NA|NA	T	Gaf domain
MAG.T21.41_02359	330214.NIDE3449	8.2e-109	399.8	Bacteria	pilU			ko:K02670					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	COG5008@1,COG5008@2	NA|NA|NA	NU	twitching motility protein
MAG.T21.41_02360	330214.NIDE3450	2.4e-63	248.4	Bacteria	ccoP			ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02361	330214.NIDE3451	1.8e-132	478.8	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02362	330214.NIDE3452	3e-60	238.0	Bacteria	rny			ko:K18682	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	COG2433@1,COG2433@2	NA|NA|NA		
MAG.T21.41_02363	330214.NIDE3454	0.0	1416.7	Bacteria													Bacteria	COG2931@1,COG2931@2	NA|NA|NA	Q	calcium- and calmodulin-responsive adenylate cyclase activity
MAG.T21.41_02365	330214.NIDE3456	4.3e-197	694.1	Bacteria	hlyD			ko:K02022,ko:K11003,ko:K12532	ko02020,ko03070,ko05133,map02020,map03070,map05133	M00325,M00326,M00575			ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1,8.A.1.3.1,8.A.1.3.2			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_02366	330214.NIDE3457	0.0	1124.8	Bacteria	hlyB			ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575			ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2			Bacteria	COG2274@1,COG2274@2	NA|NA|NA	V	protein secretion by the type I secretion system
MAG.T21.41_02368	330214.NIDE3460	6.9e-80	303.5	Bacteria	blc			ko:K03098					ko00000,ko04147				Bacteria	COG3040@1,COG3040@2	NA|NA|NA	M	lipid binding
MAG.T21.41_02369	330214.NIDE3461	3e-99	368.2	Bacteria				ko:K07714	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko02022				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_02370	330214.NIDE3462	0.0	1228.0	Bacteria	MA20_35625												Bacteria	COG2202@1,COG2202@2,COG4191@1,COG4191@2	NA|NA|NA	T	Pas domain
MAG.T21.41_02372	330214.NIDE3464	0.0	1242.3	Nitrospirae	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	3J0WY@40117,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAG.T21.41_02375	330214.NIDE3467	2.5e-136	492.3	Bacteria													Bacteria	COG3673@1,COG3673@2	NA|NA|NA	M	conserved protein
MAG.T21.41_02379	330214.NIDE0293	1.4e-42	178.7	Bacteria				ko:K02806	ko02060,map02060				ko00000,ko00001,ko01000,ko02000				Bacteria	COG3311@1,COG3311@2	NA|NA|NA	K	DNA excision
MAG.T21.41_02381	330214.NIDE0295	5.5e-234	816.6	Nitrospirae	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094					ko00000,ko01000,ko03016,ko03036				Bacteria	3J0WT@40117,COG1206@1,COG1206@2	NA|NA|NA	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MAG.T21.41_02382	330214.NIDE0296	4.1e-130	471.1	Nitrospirae	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03733,ko:K04763					ko00000,ko03036				Bacteria	3J0PS@40117,COG4974@1,COG4974@2	NA|NA|NA	L	Phage integrase, N-terminal SAM-like domain
MAG.T21.41_02383	330214.NIDE0297	2.7e-86	324.7	Nitrospirae	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419					ko00000,ko01000,ko01002				Bacteria	3J10R@40117,COG5405@1,COG5405@2	NA|NA|NA	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MAG.T21.41_02384	330214.NIDE0298	1.3e-233	815.5	Nitrospirae	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03667					ko00000,ko03110				Bacteria	3J0XE@40117,COG1220@1,COG1220@2	NA|NA|NA	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MAG.T21.41_02385	330214.NIDE0299	1.1e-156	559.3	Nitrospirae	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784	Bacteria	3J0H3@40117,COG0548@1,COG0548@2	NA|NA|NA	E	Belongs to the acetylglutamate kinase family. ArgB subfamily
MAG.T21.41_02387	330214.NIDE0301	1.8e-82	312.0	Nitrospirae	yrdA												Bacteria	3J121@40117,COG0663@1,COG0663@2	NA|NA|NA	S	Bacterial transferase hexapeptide (six repeats)
MAG.T21.41_02388	330214.NIDE0302	3.6e-250	870.5	Nitrospirae	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441			R10652	RC00003,RC03217	ko00000,ko01000,ko03009				Bacteria	3J0CD@40117,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
MAG.T21.41_02389	330214.NIDE0303	1e-244	852.4	Nitrospirae	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0X9@40117,COG0265@1,COG0265@2	NA|NA|NA	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_02390	330214.NIDE0304	8.5e-249	865.9	Nitrospirae	cusS		2.7.13.3	ko:K02484,ko:K07644,ko:K07653	ko02020,map02020	M00452,M00460,M00745			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Bacteria	3J11K@40117,COG5000@1,COG5000@2,COG5002@1,COG5002@2	NA|NA|NA	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MAG.T21.41_02391	1125863.JAFN01000001_gene724	4.1e-76	291.2	Deltaproteobacteria													Bacteria	1MU67@1224,2WJUU@28221,42N90@68525,COG0745@1,COG0745@2	NA|NA|NA	K	PFAM response regulator receiver
MAG.T21.41_02392	330214.NIDE0306	1e-159	569.7	Nitrospirae													Bacteria	3J19Q@40117,COG4783@1,COG4783@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02393	330214.NIDE0307	1.8e-157	562.4	Bacteria	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	COG4269@1,COG4269@2	NA|NA|NA	T	membrane
MAG.T21.41_02394	330214.NIDE0308	1.9e-69	270.0	Bacteria		GO:0000122,GO:0000139,GO:0000976,GO:0000977,GO:0000978,GO:0000987,GO:0000988,GO:0000989,GO:0001012,GO:0001067,GO:0001076,GO:0001190,GO:0001568,GO:0001570,GO:0001666,GO:0001837,GO:0001932,GO:0001934,GO:0001944,GO:0001947,GO:0002009,GO:0002011,GO:0002193,GO:0002376,GO:0002682,GO:0002683,GO:0003007,GO:0003143,GO:0003151,GO:0003157,GO:0003158,GO:0003160,GO:0003169,GO:0003170,GO:0003171,GO:0003174,GO:0003176,GO:0003177,GO:0003179,GO:0003180,GO:0003181,GO:0003183,GO:0003184,GO:0003188,GO:0003190,GO:0003192,GO:0003197,GO:0003198,GO:0003203,GO:0003205,GO:0003206,GO:0003207,GO:0003208,GO:0003209,GO:0003213,GO:0003214,GO:0003222,GO:0003229,GO:0003230,GO:0003231,GO:0003241,GO:0003250,GO:0003252,GO:0003256,GO:0003272,GO:0003273,GO:0003279,GO:0003281,GO:0003330,GO:0003332,GO:0003344,GO:0003348,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005912,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006357,GO:0006366,GO:0006367,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006955,GO:0006996,GO:0007049,GO:0007050,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007219,GO:0007221,GO:0007275,GO:0007368,GO:0007389,GO:0007399,GO:0007507,GO:0007517,GO:0008150,GO:0008152,GO:0008284,GO:0008285,GO:0008593,GO:0009058,GO:0009059,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010002,GO:0010033,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010562,GO:0010594,GO:0010596,GO:0010604,GO:0010605,GO:0010611,GO:0010614,GO:0010628,GO:0010629,GO:0010632,GO:0010633,GO:0010646,GO:0010647,GO:0010648,GO:0010717,GO:0010718,GO:0010720,GO:0010721,GO:0010810,GO:0010812,GO:0010830,GO:0010832,GO:0010941,GO:0010942,GO:0012505,GO:0014013,GO:0014014,GO:0014015,GO:0014031,GO:0014706,GO:0014741,GO:0014743,GO:0016020,GO:0016043,GO:0016070,GO:0016202,GO:0016324,GO:0016477,GO:0016525,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019827,GO:0019899,GO:0022008,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030030,GO:0030031,GO:0030054,GO:0030154,GO:0030155,GO:0030234,GO:0030278,GO:0030279,GO:0030334,GO:0030335,GO:0030336,GO:0030510,GO:0030513,GO:0030514,GO:0030855,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0031984,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032354,GO:0032501,GO:0032502,GO:0032774,GO:0032870,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0034698,GO:0035050,GO:0035051,GO:0035148,GO:0035239,GO:0035265,GO:0035295,GO:0035886,GO:0035924,GO:0036003,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0040009,GO:0040011,GO:0040012,GO:0040013,GO:0040017,GO:0042127,GO:0042175,GO:0042221,GO:0042325,GO:0042327,GO:0042692,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043235,GO:0043408,GO:0043410,GO:0043502,GO:0043535,GO:0043537,GO:0043565,GO:0043618,GO:0043620,GO:0044057,GO:0044085,GO:0044087,GO:0044092,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044782,GO:0045177,GO:0045445,GO:0045446,GO:0045595,GO:0045596,GO:0045597,GO:0045661,GO:0045662,GO:0045667,GO:0045668,GO:0045685,GO:0045686,GO:0045687,GO:0045747,GO:0045765,GO:0045786,GO:0045844,GO:0045892,GO:0045893,GO:0045926,GO:0045927,GO:0045934,GO:0045935,GO:0045937,GO:0045944,GO:0045967,GO:0046425,GO:0046427,GO:0046483,GO:0046578,GO:0046579,GO:0046620,GO:0046622,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048634,GO:0048636,GO:0048638,GO:0048639,GO:0048644,GO:0048646,GO:0048699,GO:0048710,GO:0048711,GO:0048713,GO:0048715,GO:0048729,GO:0048731,GO:0048738,GO:0048762,GO:0048844,GO:0048845,GO:0048856,GO:0048863,GO:0048869,GO:0048870,GO:0050767,GO:0050768,GO:0050769,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0050920,GO:0050922,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051056,GO:0051057,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051145,GO:0051147,GO:0051148,GO:0051153,GO:0051154,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051270,GO:0051271,GO:0051272,GO:0051674,GO:0051716,GO:0051726,GO:0051960,GO:0051961,GO:0051962,GO:0055001,GO:0055006,GO:0055008,GO:0055010,GO:0055021,GO:0055023,GO:0055024,GO:0055025,GO:0060039,GO:0060043,GO:0060045,GO:0060251,GO:0060253,GO:0060255,GO:0060271,GO:0060284,GO:0060317,GO:0060379,GO:0060411,GO:0060412,GO:0060415,GO:0060419,GO:0060420,GO:0060421,GO:0060429,GO:0060485,GO:0060537,GO:0060548,GO:0060560,GO:0060562,GO:0060837,GO:0060840,GO:0060841,GO:0060842,GO:0060843,GO:0060947,GO:0060948,GO:0060956,GO:0060973,GO:0060976,GO:0060977,GO:0060979,GO:0060982,GO:0061061,GO:0061311,GO:0061314,GO:0061371,GO:0061383,GO:0061384,GO:0061418,GO:0061419,GO:0065007,GO:0065009,GO:0070013,GO:0070161,GO:0070167,GO:0070168,GO:0070372,GO:0070374,GO:0070482,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071371,GO:0071372,GO:0071453,GO:0071456,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0072132,GO:0072358,GO:0072359,GO:0080090,GO:0090049,GO:0090051,GO:0090092,GO:0090100,GO:0090101,GO:0090257,GO:0090287,GO:0090288,GO:0090304,GO:0097084,GO:0097150,GO:0097159,GO:0097659,GO:0098588,GO:0098590,GO:0098727,GO:0098772,GO:0098791,GO:0098827,GO:0120031,GO:0120036,GO:0140110,GO:1901201,GO:1901213,GO:1901342,GO:1901343,GO:1901360,GO:1901362,GO:1901363,GO:1901522,GO:1901532,GO:1901533,GO:1901576,GO:1901861,GO:1901863,GO:1902337,GO:1902339,GO:1902531,GO:1902533,GO:1902679,GO:1902680,GO:1903053,GO:1903054,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1903531,GO:1903670,GO:1903671,GO:1903706,GO:1903707,GO:1904747,GO:1904748,GO:1904892,GO:1904894,GO:1905314,GO:1905456,GO:1905457,GO:1990837,GO:2000026,GO:2000027,GO:2000112,GO:2000113,GO:2000136,GO:2000137,GO:2000145,GO:2000146,GO:2000147,GO:2000181,GO:2000209,GO:2000736,GO:2000737,GO:2000811,GO:2000826,GO:2000973,GO:2000974,GO:2001026,GO:2001027,GO:2001141		ko:K06867,ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6			Bacteria	COG0457@1,COG0457@2,COG0666@1,COG0666@2	NA|NA|NA	G	response to abiotic stimulus
MAG.T21.41_02395	330214.NIDE0310	9.2e-287	992.3	Nitrospirae	frdA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_4621,iEcSMS35_1347.EcSMS35_4625,iNJ661.Rv1552,iPC815.YPO0360	Bacteria	3J0ZM@40117,COG1053@1,COG1053@2	NA|NA|NA	C	Fumarate reductase flavoprotein C-term
MAG.T21.41_02396	330214.NIDE0312	0.0	1760.0	Nitrospirae	gcvP	GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3318	Bacteria	3J0XT@40117,COG0403@1,COG0403@2,COG1003@1,COG1003@2	NA|NA|NA	E	Glycine cleavage system P-protein
MAG.T21.41_02398	330214.NIDE0314	3.3e-146	524.6	Bacteria	iunH		3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100		R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000				Bacteria	COG1957@1,COG1957@2	NA|NA|NA	F	ribosylpyrimidine nucleosidase activity
MAG.T21.41_02399	314262.MED193_18729	9.9e-49	199.5	Proteobacteria													Bacteria	1QVDX@1224,COG3598@1,COG3598@2	NA|NA|NA	L	PFAM TOPRIM domain protein
MAG.T21.41_02400	1122970.AUHC01000004_gene2397	4.6e-59	234.2	Alphaproteobacteria			3.1.22.4	ko:K01159	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1RCYK@1224,2U727@28211,COG0817@1,COG0817@2	NA|NA|NA	L	genomic island protein Bartonella henselae str. Houston-1 gi 49238285 emb CAF27499.1 and to
MAG.T21.41_02401	991905.SL003B_4058	2.3e-20	104.8	unclassified Alphaproteobacteria													Bacteria	1PKZB@1224,2E46I@1,2UZKV@28211,2ZYES@2,4BT1K@82117	NA|NA|NA		
MAG.T21.41_02402	1502724.FF80_03329	2.8e-09	68.9	Alphaproteobacteria													Bacteria	1NE9B@1224,2DQAW@1,2UGZ4@28211,335Q1@2	NA|NA|NA	S	genomic island protein Bartonella henselae str. Houston-1 gi 49238509 emb CAF27741.1 and to
MAG.T21.41_02403	717785.HYPMC_1997	2.7e-85	322.0	Hyphomicrobiaceae													Bacteria	1MVMJ@1224,2TS5R@28211,3N8PI@45401,COG4705@1,COG4705@2	NA|NA|NA	S	Repeat of Unknown Function (DUF347)
MAG.T21.41_02404	394.NGR_c00910	6.7e-47	194.9	Alphaproteobacteria													Bacteria	1R4F2@1224,2BVRA@1,2U0VD@28211,2Z7NJ@2	NA|NA|NA		
MAG.T21.41_02405	536019.Mesop_0919	1.1e-98	366.3	Phyllobacteriaceae													Bacteria	1MVMJ@1224,2TS5R@28211,43J1W@69277,COG4705@1,COG4705@2	NA|NA|NA	S	Repeat of Unknown Function (DUF347)
MAG.T21.41_02406	1288826.MSNKSG1_02018	1.5e-38	166.4	Proteobacteria													Bacteria	1RFXY@1224,COG4705@1,COG4705@2	NA|NA|NA	S	Repeat of Unknown Function (DUF347)
MAG.T21.41_02407	1500306.JQLA01000028_gene3822	1.1e-17	96.3	Rhizobiaceae													Bacteria	1PXUV@1224,2UZKX@28211,4BKFJ@82115,COG4705@1,COG4705@2	NA|NA|NA	S	Repeat of Unknown Function (DUF347)
MAG.T21.41_02408	443598.AUFA01000037_gene5131	6e-102	377.9	Bradyrhizobiaceae				ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1MXGK@1224,2TVKT@28211,3JSJG@41294,COG0559@1,COG0559@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T21.41_02409	330214.NIDE3027	3.6e-137	494.2	Nitrospirae	kdtX			ko:K12984					ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2		Bacteria	3J0M5@40117,COG0463@1,COG0463@2	NA|NA|NA	M	biosynthesis glycosyltransferase
MAG.T21.41_02410	330214.NIDE3028	0.0	1089.3	Bacteria	ltaS2		2.7.8.20	ko:K01002,ko:K01138	ko01100,map01100				ko00000,ko01000				Bacteria	COG1368@1,COG1368@2	NA|NA|NA	M	sulfuric ester hydrolase activity
MAG.T21.41_02411	330214.NIDE3029	4.8e-167	594.0	Nitrospirae				ko:K00754					ko00000,ko01000		GT4		Bacteria	3J129@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferase 4-like domain
MAG.T21.41_02412	330214.NIDE3030	1e-156	559.7	Nitrospirae				ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	3J0KI@40117,COG0859@1,COG0859@2	NA|NA|NA	M	Glycosyltransferase family 9 (heptosyltransferase)
MAG.T21.41_02413	330214.NIDE3031	9.5e-287	992.3	Nitrospirae	rfaF		2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28	ko:K02843,ko:K02849,ko:K03271,ko:K03272,ko:K03273	ko00540,ko01100,map00540,map01100	M00064,M00080	R05644,R05645,R05646,R05647,R09768,R09769,R09771	RC00002,RC00017,RC00078,RC00434	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9		Bacteria	3J0PZ@40117,COG0241@1,COG0241@2,COG0859@1,COG0859@2	NA|NA|NA	EM	Glycosyltransferase family 9 (heptosyltransferase)
MAG.T21.41_02414	864702.OsccyDRAFT_1522	2e-49	203.4	Oscillatoriales	tnp												Bacteria	1G4RX@1117,1HHM0@1150,COG3547@1,COG3547@2	NA|NA|NA	L	PFAM Transposase IS116 IS110 IS902 family
MAG.T21.41_02415	330214.NIDE0739	1.6e-48	199.1	Bacteria				ko:K00754					ko00000,ko01000		GT4		Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_02416	330214.NIDE0740	9.8e-192	676.0	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_02417	330214.NIDE0741	1.5e-166	592.8	Bacteria													Bacteria	COG2244@1,COG2244@2	NA|NA|NA	S	polysaccharide biosynthetic process
MAG.T21.41_02418	330214.NIDE0742	1.7e-112	412.5	Bacteria	ywdF	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T21.41_02419	330214.NIDE0743	1.4e-184	652.5	Bacteria													Bacteria	COG3875@1,COG3875@2	NA|NA|NA	S	lactate racemase activity
MAG.T21.41_02420	330214.NIDE0744	2.1e-262	911.4	Bacteria				ko:K14340					ko00000,ko01000,ko01003				Bacteria	COG1807@1,COG1807@2	NA|NA|NA	M	4-amino-4-deoxy-L-arabinose transferase activity
MAG.T21.41_02421	330214.NIDE0631	2.7e-191	674.5	Bacteria													Bacteria	COG4313@1,COG4313@2	NA|NA|NA		
MAG.T21.41_02422	330214.NIDE0629	1.5e-87	328.9	Bacteria	yneN												Bacteria	COG0526@1,COG0526@2	NA|NA|NA	CO	cell redox homeostasis
MAG.T21.41_02423	330214.NIDE0628	5.7e-92	344.7	Nitrospirae				ko:K03832					ko00000,ko02000	2.C.1.1			Bacteria	3J0U0@40117,COG0810@1,COG0810@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02428	330214.NIDE0623	0.0	1667.9	Nitrospirae	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680		ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	3J0E5@40117,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MAG.T21.41_02429	330214.NIDE0616	1.5e-207	728.8	Nitrospirae													Bacteria	3J0P0@40117,COG1565@1,COG1565@2	NA|NA|NA	S	Putative S-adenosyl-L-methionine-dependent methyltransferase
MAG.T21.41_02430	330214.NIDE0615	2.5e-59	234.6	Nitrospirae	nuoA		1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0MS@40117,COG0838@1,COG0838@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_02431	330214.NIDE0614	3.5e-85	320.9	Nitrospirae	nuoB		1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J11S@40117,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_02432	330214.NIDE0613	0.0	1139.4	Nitrospirae	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332,ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0FM@40117,COG0649@1,COG0649@2,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_02433	330214.NIDE0612	2.4e-90	338.2	Bacteria	nuoE		1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6			Bacteria	COG1905@1,COG1905@2	NA|NA|NA	C	2 iron, 2 sulfur cluster binding
MAG.T21.41_02434	330214.NIDE0611	2.7e-241	840.9	Nitrospirae	nuoF2		1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0WX@40117,COG1894@1,COG1894@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
MAG.T21.41_02435	330214.NIDE0609	0.0	1588.9	Nitrospirae	hcnA		1.4.99.5,1.5.3.1	ko:K00302,ko:K10814	ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110		R00374,R00610,R05704	RC00060,RC00557,RC02808	ko00000,ko00001,ko01000,ko02042				Bacteria	3J0UR@40117,COG3383@1,COG3383@2	NA|NA|NA	C	Molydopterin dinucleotide binding domain
MAG.T21.41_02436	330214.NIDE0608	5.5e-192	676.8	Nitrospirae	nuoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0E2@40117,COG1005@1,COG1005@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MAG.T21.41_02437	330214.NIDE0607	2e-95	355.1	Nitrospirae	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3,1.6.99.3	ko:K00338,ko:K02573,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6			Bacteria	3J0N0@40117,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_02438	330214.NIDE0606	9.8e-62	243.0	Nitrospirae	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0RP@40117,COG0839@1,COG0839@2	NA|NA|NA	C	Belongs to the complex I subunit 6 family
MAG.T21.41_02439	330214.NIDE0605	1.4e-39	168.7	Nitrospirae	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0SN@40117,COG0713@1,COG0713@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T21.41_02440	330214.NIDE0604	0.0	1177.2	Nitrospirae	nuoL		1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0AN@40117,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-quinone oxidoreductase
MAG.T21.41_02441	365044.Pnap_0430	5.5e-17	93.6	Betaproteobacteria				ko:K07483					ko00000				Bacteria	1N8W3@1224,2WEXS@28216,COG2963@1,COG2963@2	NA|NA|NA	L	PFAM transposase IS3 IS911 family protein
MAG.T21.41_02442	935261.JAGL01000008_gene2301	2.8e-90	338.6	Phyllobacteriaceae				ko:K07497					ko00000				Bacteria	1MVC8@1224,2TRX0@28211,43HWH@69277,COG2801@1,COG2801@2	NA|NA|NA	L	DDE domain
MAG.T21.41_02443	189753.AXAS01000037_gene7858	1.5e-20	107.8	Bradyrhizobiaceae				ko:K07481					ko00000				Bacteria	1QQ9Q@1224,2UEEB@28211,3K063@41294,COG3039@1,COG3039@2	NA|NA|NA	L	Transposase
MAG.T21.41_02444	1278073.MYSTI_02311	9.3e-129	466.8	Myxococcales	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03544	ko04112,map04112				ko00000,ko00001,ko03110				Bacteria	1MVQK@1224,2WJ8Q@28221,2YUHC@29,42MWJ@68525,COG1219@1,COG1219@2	NA|NA|NA	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MAG.T21.41_02450	330214.NIDE1889	5.4e-72	276.9	Nitrospirae	msrB		1.8.4.12	ko:K07305					ko00000,ko01000				Bacteria	3J17K@40117,COG0229@1,COG0229@2	NA|NA|NA	C	SelR domain
MAG.T21.41_02451	330214.NIDE1890	0.0	1443.7	Nitrospirae	lon		3.4.21.53	ko:K01338	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0DQ@40117,COG0466@1,COG0466@2	NA|NA|NA	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MAG.T21.41_02452	330214.NIDE1891	4e-234	817.8	Bacteria			2.7.11.1	ko:K08884					ko00000,ko01000,ko01001				Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_02453	330214.NIDE1892	2e-256	891.3	Nitrospirae	otsA		2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135,3.1.3.12	ko:K00697,ko:K13057,ko:K16055,ko:K20436	ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130	M00815	R02737,R02778,R08946,R10525,R11239,R11250,R11306,R11497	RC00005,RC00017,RC00049,RC02748,RC03400,RC03401	ko00000,ko00001,ko00002,ko01000,ko01003		GT20,GT4		Bacteria	3J10Z@40117,COG0380@1,COG0380@2	NA|NA|NA	G	Glycosyltransferase family 20
MAG.T21.41_02454	330214.NIDE1893	8e-173	613.2	Bacteria	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	COG0116@1,COG0116@2	NA|NA|NA	L	23S rRNA (guanine(2445)-N(2))-methyltransferase activity
MAG.T21.41_02455	330214.NIDE1894	3.3e-92	344.4	Bacteria			3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000				Bacteria	COG1051@1,COG1051@2	NA|NA|NA	F	GDP-mannose mannosyl hydrolase activity
MAG.T21.41_02456	330214.NIDE1895	1.3e-32	145.6	Bacteria	hesB			ko:K07390,ko:K13628,ko:K15724					ko00000,ko03016,ko03029,ko03110				Bacteria	COG0316@1,COG0316@2	NA|NA|NA	S	protein maturation
MAG.T21.41_02457	330214.NIDE1896	4e-38	163.7	Bacteria				ko:K06218					ko00000,ko02048				Bacteria	COG2026@1,COG2026@2	NA|NA|NA	DJ	nuclease activity
MAG.T21.41_02459	330214.NIDE1902	7.3e-84	316.6	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_02460	330214.NIDE1906	1.2e-198	699.1	Nitrospirae	yhaO			ko:K03547					ko00000,ko03400				Bacteria	3J0UK@40117,COG0420@1,COG0420@2	NA|NA|NA	L	Calcineurin-like phosphoesterase superfamily domain
MAG.T21.41_02461	330214.NIDE1907	0.0	1223.8	Nitrospirae													Bacteria	3J110@40117,COG1196@1,COG1196@2,COG4717@1,COG4717@2	NA|NA|NA	D	AAA domain
MAG.T21.41_02462	330214.NIDE1909	2e-105	388.7	Bacteria			1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	COG4221@1,COG4221@2	NA|NA|NA	IQ	oxidoreductase activity
MAG.T21.41_02463	330214.NIDE1910	4e-76	290.8	Bacteria				ko:K07034					ko00000				Bacteria	COG1584@1,COG1584@2	NA|NA|NA	S	GPR1 FUN34 yaaH family protein
MAG.T21.41_02464	330214.NIDE2651	1.8e-100	373.2	Bacteria	asgA			ko:K02666,ko:K03497,ko:K19622	ko02020,map02020				ko00000,ko00001,ko02022,ko02035,ko02044,ko03000,ko03036,ko04812	3.A.15.2			Bacteria	COG0784@1,COG0784@2,COG1196@1,COG1196@2	NA|NA|NA	D	nuclear chromosome segregation
MAG.T21.41_02465	330214.NIDE0754	9.8e-47	192.6	Bacteria													Bacteria	2DT1T@1,33IAD@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_02466	330214.NIDE0753	6.6e-141	506.9	Nitrospirae	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438					ko00000,ko01000,ko03009				Bacteria	3J0NU@40117,COG0275@1,COG0275@2	NA|NA|NA	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MAG.T21.41_02467	330214.NIDE0751	5.3e-229	800.0	Bacteria	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	COG0017@1,COG0017@2	NA|NA|NA	J	Asparaginyl-tRNA synthetase
MAG.T21.41_02469	330214.NIDE0749	5.8e-106	391.0	Bacteria	hcf136												Bacteria	COG4447@1,COG4447@2	NA|NA|NA	S	cellulose binding
MAG.T21.41_02470	330214.NIDE0748	8.3e-66	256.5	Nitrospirae	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K09767					ko00000				Bacteria	3J135@40117,COG1666@1,COG1666@2	NA|NA|NA	S	Protein of unknown function (DUF520)
MAG.T21.41_02471	330214.NIDE0747	0.0	1207.6	Nitrospirae	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K06200					ko00000				Bacteria	3J10E@40117,COG1966@1,COG1966@2	NA|NA|NA	T	5TM C-terminal transporter carbon starvation CstA
MAG.T21.41_02472	765911.Thivi_1781	3.6e-08	63.5	Chromatiales													Bacteria	1NE58@1224,1SG82@1236,1X20I@135613,2DPTZ@1,333CW@2	NA|NA|NA		
MAG.T21.41_02474	330214.NIDE1885	2e-103	382.1	Bacteria				ko:K16079					ko00000,ko02000	1.B.4.2.1			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_02475	330214.NIDE1884	5e-70	270.8	Bacteria	dsbL			ko:K03673	ko01503,map01503	M00728			ko00000,ko00001,ko00002,ko03110				Bacteria	COG2761@1,COG2761@2	NA|NA|NA	Q	protein disulfide oxidoreductase activity
MAG.T21.41_02476	330214.NIDE1882	2.5e-102	378.3	Bacteria	kynB		1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1878@1,COG1878@2	NA|NA|NA	S	arylformamidase activity
MAG.T21.41_02480	330214.NIDE0200	5.8e-48	197.2	Bacteria	prc		3.4.21.102	ko:K03797					ko00000,ko01000,ko01002				Bacteria	COG0793@1,COG0793@2	NA|NA|NA	M	Belongs to the peptidase S41A family
MAG.T21.41_02481	575540.Isop_2983	1.5e-08	66.2	Planctomycetes													Bacteria	2A5QN@1,2J3JM@203682,30UFH@2	NA|NA|NA	S	Domain of unknown function (DUF4149)
MAG.T21.41_02482	330214.NIDE0198	1e-133	483.0	Bacteria	yfcH			ko:K07071					ko00000				Bacteria	COG1090@1,COG1090@2	NA|NA|NA	S	coenzyme binding
MAG.T21.41_02484	330214.NIDE0195	2.4e-129	468.4	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02486	330214.NIDE0193	8.8e-182	642.9	Nitrospirae			1.14.99.50	ko:K18912	ko00340,map00340		R11013	RC03323,RC03324	ko00000,ko00001,ko01000				Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02487	330214.NIDE0192	6.3e-171	606.7	Nitrospirae			1.14.99.50	ko:K18912	ko00340,map00340		R11013	RC03323,RC03324	ko00000,ko00001,ko01000				Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02489	330214.NIDE0190	6.5e-141	506.9	Bacteria	ycgE			ko:K21089,ko:K21972,ko:K22491	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	COG0789@1,COG0789@2,COG5012@1,COG5012@2	NA|NA|NA	T	cobalamin binding
MAG.T21.41_02490	330214.NIDE0189	1.7e-40	172.2	Bacteria													Bacteria	COG3011@1,COG3011@2	NA|NA|NA	CH	Protein conserved in bacteria
MAG.T21.41_02491	426114.THI_2428	1.1e-12	79.7	unclassified Burkholderiales	rnhA		3.1.26.4	ko:K03469	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	1KKSW@119065,1RCZ1@1224,2VR4W@28216,COG0328@1,COG0328@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MAG.T21.41_02492	330214.NIDE0187	9e-48	197.2	Bacteria	fliL			ko:K02415					ko00000,ko02035				Bacteria	COG1580@1,COG1580@2	NA|NA|NA	N	Controls the rotational direction of flagella during chemotaxis
MAG.T21.41_02495	330214.NIDE0169	1.8e-70	271.9	Nitrospirae	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02939	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0MQ@40117,COG0359@1,COG0359@2	NA|NA|NA	J	binds to the 23S rRNA
MAG.T21.41_02496	330214.NIDE0168	2.3e-229	801.2	Nitrospirae	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_3081	Bacteria	3J0CB@40117,COG0112@1,COG0112@2	NA|NA|NA	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MAG.T21.41_02497	330214.NIDE0167	5.6e-64	250.4	Nitrospirae	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07738					ko00000,ko03000				Bacteria	3J14C@40117,COG1327@1,COG1327@2	NA|NA|NA	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MAG.T21.41_02498	330214.NIDE0166	3.8e-191	674.1	Bacteria			1.1.1.103,2.7.13.3	ko:K00060,ko:K07777	ko00260,ko02020,map00260,map02020	M00478	R01465	RC00525	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG1063@1,COG1063@2,COG4585@1,COG4585@2	NA|NA|NA	E	alcohol dehydrogenase
MAG.T21.41_02499	330214.NIDE0165	6.9e-116	423.3	Nitrospirae	degU			ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	M00478			ko00000,ko00001,ko00002,ko02022				Bacteria	3J18V@40117,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T21.41_02500	330214.NIDE0164	4.5e-158	563.9	Nitrospirae	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108,4.2.1.59	ko:K02535,ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005			iECS88_1305.ECS88_0100	Bacteria	3J0JG@40117,COG0774@1,COG0774@2	NA|NA|NA	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
MAG.T21.41_02502	330214.NIDE0161	3e-121	441.4	Nitrospirae	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0I4@40117,COG0483@1,COG0483@2	NA|NA|NA	G	Inositol monophosphatase family
MAG.T21.41_02504	330214.NIDE0159	4.7e-57	226.9	Bacteria	yurZ		2.3.1.12,4.1.1.44	ko:K00627,ko:K01607	ko00010,ko00020,ko00362,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00020,map00362,map00620,map01100,map01110,map01120,map01130,map01200,map01220	M00307	R00209,R02569,R03470	RC00004,RC00938,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0599@1,COG0599@2	NA|NA|NA	S	peroxiredoxin activity
MAG.T21.41_02505	330214.NIDE0158	0.0	1171.8	Bacteria													Bacteria	COG1032@1,COG1032@2	NA|NA|NA	C	radical SAM domain protein
MAG.T21.41_02506	330214.NIDE0156	1.2e-55	222.2	Bacteria	phhB	GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.2.1.96	ko:K01724	ko00790,map00790		R04734	RC01208	ko00000,ko00001,ko01000,ko04147				Bacteria	COG2154@1,COG2154@2	NA|NA|NA	H	pterin-4-alpha-carbinolamine dehydratase
MAG.T21.41_02507	330214.NIDE0155	8.4e-79	299.7	Bacteria				ko:K07182					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_02508	1198232.CYCME_1120	1.9e-26	125.9	Thiotrichales	ugpQ		3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000				Bacteria	1MU8H@1224,1RQWX@1236,462GH@72273,COG0584@1,COG0584@2	NA|NA|NA	C	Glycerophosphoryl diester phosphodiesterase family
MAG.T21.41_02509	330214.NIDE0153	5.8e-73	280.4	Bacteria													Bacteria	COG0668@1,COG0668@2	NA|NA|NA	M	transmembrane transport
MAG.T21.41_02510	330214.NIDE0150	1.8e-76	292.4	Bacteria													Bacteria	2ETF9@1,33KZ8@2	NA|NA|NA	S	Domain of unknown function (DUF4412)
MAG.T21.41_02511	330214.NIDE0149	3.8e-106	391.3	Bacteria													Bacteria	2ETF9@1,33KZ8@2	NA|NA|NA	S	Domain of unknown function (DUF4412)
MAG.T21.41_02512	330214.NIDE0147	9.6e-128	463.0	Nitrospirae			2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	3J111@40117,COG2326@1,COG2326@2	NA|NA|NA	S	Polyphosphate kinase 2 (PPK2)
MAG.T21.41_02513	330214.NIDE0146	1.7e-87	328.6	Bacteria													Bacteria	COG2110@1,COG2110@2	NA|NA|NA	P	phosphatase homologous to the C-terminal domain of histone macroH2A1
MAG.T21.41_02514	330214.NIDE0145	3.5e-111	407.9	Nitrospirae	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K01087,ko:K16055	ko00500,ko01100,map00500,map01100		R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Bacteria	3J0UY@40117,COG1877@1,COG1877@2	NA|NA|NA	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose
MAG.T21.41_02515	330214.NIDE0144	8e-168	596.3	Nitrospirae	otsA		2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135	ko:K00697,ko:K13057,ko:K20436	ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130	M00815	R02737,R08946,R10525,R11239,R11250,R11306,R11497	RC00005,RC00049,RC02748,RC03400,RC03401	ko00000,ko00001,ko00002,ko01000,ko01003		GT20,GT4		Bacteria	3J109@40117,COG0380@1,COG0380@2	NA|NA|NA	M	Glycosyltransferase family 20
MAG.T21.41_02517	1121104.AQXH01000004_gene142	3.4e-124	451.8	Sphingobacteriia	ndh		1.6.99.3	ko:K03885	ko00190,map00190				ko00000,ko00001,ko01000				Bacteria	1IQYG@117747,4NE0H@976,COG1252@1,COG1252@2	NA|NA|NA	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase
MAG.T21.41_02518	330214.NIDE3498	9.5e-297	1025.8	Bacteria	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132				ko00000,ko00001,ko03000				Bacteria	COG2203@1,COG2203@2,COG3604@1,COG3604@2	NA|NA|NA	KT	transcription factor binding
MAG.T21.41_02519	861299.J421_5702	4.8e-12	77.4	Gemmatimonadetes													Bacteria	1ZTKN@142182,COG4454@1,COG4454@2	NA|NA|NA		
MAG.T21.41_02520	404589.Anae109_2916	1.8e-62	246.5	Deltaproteobacteria			4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000				Bacteria	1PKS2@1224,2WPSR@28221,42T45@68525,COG2203@1,COG2203@2,COG3576@1,COG3576@2	NA|NA|NA	T	pyridoxamine 5'-phosphate oxidase-related FMN-binding
MAG.T21.41_02521	1121377.KB906398_gene2383	2.8e-61	241.5	Bacteria													Bacteria	2B5NQ@1,31YI3@2	NA|NA|NA	S	Domain of unknown function (DUF4188)
MAG.T21.41_02522	330214.NIDE3499	1.2e-29	136.3	Bacteria													Bacteria	2C7J2@1,33AYB@2	NA|NA|NA		
MAG.T21.41_02523	330214.NIDE3500	9.1e-82	309.7	Bacteria	lemA			ko:K03744					ko00000				Bacteria	COG1704@1,COG1704@2	NA|NA|NA	S	LemA family
MAG.T21.41_02524	330214.NIDE3501	5.7e-237	827.0	Bacteria	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	COG4907@1,COG4907@2	NA|NA|NA	P	membrane protein (DUF2207)
MAG.T21.41_02526	1162668.LFE_0941	1.2e-27	129.8	Nitrospirae													Bacteria	3J19G@40117,COG3558@1,COG3558@2	NA|NA|NA	S	Domain of unknown function (DUF5069)
MAG.T21.41_02527	63737.Npun_R0239	4.8e-100	371.3	Bacteria													Bacteria	COG2520@1,COG2520@2	NA|NA|NA	J	tRNA (guanine(37)-N(1))-methyltransferase activity
MAG.T21.41_02528	330214.NIDE3502	0.0	1609.0	Bacteria													Bacteria	COG3387@1,COG3387@2	NA|NA|NA	G	glucan 1,4-alpha-glucosidase activity
MAG.T21.41_02530	330214.NIDE3507	2.1e-60	238.8	Bacteria	rimL		2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Bacteria	COG1670@1,COG1670@2	NA|NA|NA	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAG.T21.41_02531	330214.NIDE3508	2.8e-119	434.9	Bacteria													Bacteria	28N6F@1,2ZBBB@2	NA|NA|NA		
MAG.T21.41_02533	870187.Thini_2229	8.7e-24	116.7	Proteobacteria	vapC												Bacteria	1N7ET@1224,COG4113@1,COG4113@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T21.41_02534	661478.OP10G_3987	2.4e-07	61.2	Bacteria				ko:K21495					ko00000,ko02048				Bacteria	2DSE5@1,33FS0@2	NA|NA|NA		
MAG.T21.41_02535	153948.NAL212_2760	1.8e-35	155.2	Nitrosomonadales													Bacteria	1PW2Z@1224,2AI5X@1,2WBP3@28216,318K6@2,373HR@32003	NA|NA|NA		
MAG.T21.41_02536	305900.GV64_11265	1.5e-58	234.6	Oceanospirillales				ko:K07001					ko00000				Bacteria	1Q82E@1224,1RRUE@1236,1XMRQ@135619,COG1752@1,COG1752@2	NA|NA|NA	S	Patatin-like phospholipase
MAG.T21.41_02542	330214.NIDE3510	2.3e-65	255.8	Bacteria													Bacteria	2DT3N@1,33IIR@2	NA|NA|NA		
MAG.T21.41_02543	330214.NIDE3764	2.5e-79	302.0	Bacteria													Bacteria	28PNA@1,2ZCB3@2	NA|NA|NA	S	Transglycosylase SLT domain
MAG.T21.41_02544	1122604.JONR01000045_gene2483	4.6e-144	518.1	Proteobacteria													Bacteria	1MXRI@1224,2DBEC@1,2Z8RY@2	NA|NA|NA	S	Domain of unknown function (DUF3943)
MAG.T21.41_02545	330214.NIDE3513	2.3e-174	618.2	Bacteria													Bacteria	COG0667@1,COG0667@2	NA|NA|NA	C	Aldo Keto reductase
MAG.T21.41_02546	330214.NIDE3514	9e-95	353.2	Nitrospirae			3.1.3.18	ko:K01091,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	3J11X@40117,COG0546@1,COG0546@2	NA|NA|NA	S	phosphoglycolate phosphatase activity
MAG.T21.41_02547	330214.NIDE3515	0.0	1539.6	Nitrospirae	xfp		4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120		R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000				Bacteria	3J10J@40117,COG3957@1,COG3957@2	NA|NA|NA	H	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
MAG.T21.41_02548	330214.NIDE3516	5e-173	614.0	Nitrospirae	ackA		2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000				Bacteria	3J12N@40117,COG0282@1,COG0282@2	NA|NA|NA	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MAG.T21.41_02550	330214.NIDE3518	3.5e-95	354.8	Nitrospirae	dsbA												Bacteria	3J19Z@40117,COG1651@1,COG1651@2	NA|NA|NA	O	DSBA-like thioredoxin domain
MAG.T21.41_02551	330214.NIDE3519	7.2e-28	130.2	Bacteria			1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_02552	330214.NIDE3522	3.2e-107	394.8	Bacteria				ko:K09939					ko00000				Bacteria	COG3182@1,COG3182@2	NA|NA|NA	E	Iron-regulated membrane protein
MAG.T21.41_02553	330214.NIDE3523	1.3e-111	409.5	Bacteria													Bacteria	COG5266@1,COG5266@2	NA|NA|NA	P	PFAM Nickel transport complex, NikM subunit, transmembrane
MAG.T21.41_02554	330214.NIDE3524	0.0	1420.2	Bacteria													Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_02555	330214.NIDE3525	7.7e-135	486.9	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_02556	330214.NIDE3526	4.2e-76	290.8	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_02557	330214.NIDE3527	0.0	1711.8	Nitrospirae	mdtC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Bacteria	3J0XV@40117,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_02558	330214.NIDE3528	5.4e-46	190.3	Nitrospirae	mdtB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Bacteria	3J0XV@40117,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_02559	909613.UO65_0305	1.2e-38	167.5	Bacteria													Bacteria	2A5G6@1,30U67@2	NA|NA|NA		
MAG.T21.41_02560	330214.NIDE2456	1.3e-146	525.8	Nitrospirae	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100		R00104	RC00002,RC00078	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	Bacteria	3J0HS@40117,COG0061@1,COG0061@2	NA|NA|NA	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MAG.T21.41_02561	330214.NIDE2455	4.7e-236	823.5	Bacteria	preT		1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00528,ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R10159,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0493@1,COG0493@2	NA|NA|NA	C	'glutamate synthase
MAG.T21.41_02562	330214.NIDE2454	1.1e-50	205.7	Nitrospirae	fumC		4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0FU@40117,COG0114@1,COG0114@2	NA|NA|NA	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MAG.T21.41_02563	472759.Nhal_1792	1.2e-105	390.2	Chromatiales	MA20_29525			ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1QTT0@1224,1RNBT@1236,1WXZV@135613,COG4773@1,COG4773@2	NA|NA|NA	P	TonB dependent receptor
MAG.T21.41_02564	330214.NIDE1252	1.8e-108	398.7	Bacteria													Bacteria	COG0330@1,COG0330@2	NA|NA|NA	O	stress-induced mitochondrial fusion
MAG.T21.41_02566	330214.NIDE2246	1.8e-85	322.8	Bacteria													Bacteria	COG1801@1,COG1801@2	NA|NA|NA	L	Protein of unknown function DUF72
MAG.T21.41_02567	330214.NIDE1254	0.0	1271.1	Nitrospirae	malQ		2.4.1.18,2.4.1.25	ko:K00700,ko:K00705	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R05196	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13,GH77	iJN678.malQ	Bacteria	3J106@40117,COG1640@1,COG1640@2	NA|NA|NA	G	4-alpha-glucanotransferase
MAG.T21.41_02569	330214.NIDE1470	9.1e-29	133.3	Bacteria				ko:K21572					ko00000,ko02000	8.A.46.1,8.A.46.3			Bacteria	COG2913@1,COG2913@2	NA|NA|NA	J	Gram-negative-bacterium-type cell outer membrane assembly
MAG.T21.41_02571	330214.NIDE1472	2.6e-212	744.6	Nitrospirae	rhlE		3.6.4.13	ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	3J0ZA@40117,COG0513@1,COG0513@2	NA|NA|NA	F	helicase superfamily c-terminal domain
MAG.T21.41_02574	330214.NIDE1475	1.5e-254	885.2	Nitrospirae	fhlA			ko:K02584,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132				ko00000,ko00001,ko03000				Bacteria	3J1FR@40117,COG2203@1,COG2203@2,COG3829@1,COG3829@2	NA|NA|NA	KT	Evidence 2b Function of strongly homologous gene
MAG.T21.41_02575	330214.NIDE4073	4.9e-150	538.1	Bacteria	VPA1441												Bacteria	COG3203@1,COG3203@2	NA|NA|NA	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MAG.T21.41_02577	311402.Avi_2353	7.8e-14	84.3	Rhizobiaceae													Bacteria	1P6HT@1224,2999F@1,2UWRH@28211,2ZWCN@2,4BGKP@82115	NA|NA|NA		
MAG.T21.41_02579	330214.NIDE2901	1.8e-99	368.6	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_02580	330214.NIDE2902	5.9e-152	543.9	Bacteria	aepY		4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130		R04053	RC00506	ko00000,ko00001,ko01000				Bacteria	COG0028@1,COG0028@2	NA|NA|NA	EH	Belongs to the TPP enzyme family
MAG.T21.41_02581	330214.NIDE2903	6.5e-285	986.1	Bacteria	pepM		2.7.7.74,5.4.2.9	ko:K01841,ko:K07281	ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130		R00661,R09669	RC00002,RC02792	ko00000,ko00001,ko01000				Bacteria	COG1213@1,COG1213@2,COG2513@1,COG2513@2	NA|NA|NA	M	nucleotidyl transferase
MAG.T21.41_02583	330214.NIDE2906	1e-204	719.5	Nitrospirae	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003		GT5		Bacteria	3J0DJ@40117,COG0297@1,COG0297@2	NA|NA|NA	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose
MAG.T21.41_02585	330214.NIDE2908	1.7e-60	238.4	Nitrospirae				ko:K03593					ko00000,ko03029,ko03036				Bacteria	3J1AV@40117,COG3536@1,COG3536@2	NA|NA|NA	S	Protein of unknown function (DUF971)
MAG.T21.41_02586	330214.NIDE2909	2.9e-126	458.0	Nitrospirae	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.6.99.2	ko:K03474,ko:K03584	ko00750,ko01100,ko03440,map00750,map01100,map03440	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	3J0S8@40117,COG1381@1,COG1381@2	NA|NA|NA	L	Involved in DNA repair and RecF pathway recombination
MAG.T21.41_02587	330214.NIDE2910	1e-204	719.5	Bacteria	mgtE			ko:K06213					ko00000,ko02000	1.A.26.1			Bacteria	COG2239@1,COG2239@2	NA|NA|NA	P	Acts as a magnesium transporter
MAG.T21.41_02588	330214.NIDE2911	6.3e-149	533.5	Nitrospirae	era	GO:0000028,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006275,GO:0006996,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065003,GO:0065007,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113		ko:K03595,ko:K06883					ko00000,ko03009,ko03029				Bacteria	3J0IB@40117,COG1159@1,COG1159@2	NA|NA|NA	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MAG.T21.41_02589	330214.NIDE2912	2.2e-44	184.9	Bacteria	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944		ko:K05589					ko00000,ko03036				Bacteria	COG2919@1,COG2919@2	NA|NA|NA	D	cell cycle
MAG.T21.41_02590	330214.NIDE2913	4.6e-233	813.5	Nitrospirae	eno		4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147				Bacteria	3J0DB@40117,COG0148@1,COG0148@2	NA|NA|NA	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MAG.T21.41_02591	330214.NIDE2915	1.7e-249	868.2	Nitrospirae	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.12,6.3.5.6,6.3.5.7	ko:K01876,ko:K02434	ko00970,ko01100,map00970,map01100	M00359,M00360	R03905,R04212,R05577	RC00010,RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	3J0FK@40117,COG0064@1,COG0064@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T21.41_02592	330214.NIDE2916	9.3e-42	176.0	Nitrospirae	XK27_07760												Bacteria	3J1B3@40117,COG4980@1,COG4980@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02593	330214.NIDE2917	5.5e-52	210.3	Bacteria	WQ51_05790												Bacteria	COG4768@1,COG4768@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF948)
MAG.T21.41_02594	330214.NIDE2918	1.1e-257	895.6	Nitrospirae	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	3J0AA@40117,COG0154@1,COG0154@2	NA|NA|NA	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MAG.T21.41_02595	330214.NIDE2919	1.7e-60	238.4	Nitrospirae	panD		4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0Q2@40117,COG0853@1,COG0853@2	NA|NA|NA	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MAG.T21.41_02596	330214.NIDE2920	2.8e-37	161.0	Nitrospirae	gatC		6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029			iAF987.Gmet_0076	Bacteria	3J0V3@40117,COG0721@1,COG0721@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T21.41_02597	330214.NIDE2921	0.0	1167.9	Nitrospirae	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002			iAF987.Gmet_1487	Bacteria	3J0CP@40117,COG0449@1,COG0449@2	NA|NA|NA	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MAG.T21.41_02598	330214.NIDE2922	3.5e-246	857.4	Nitrospirae	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528,ko:K16203	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000,ko01002	3.A.1.5.2		iJN678.glmU,iLJ478.TM1629	Bacteria	3J0CG@40117,COG1207@1,COG1207@2	NA|NA|NA	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MAG.T21.41_02599	330214.NIDE2923	1.4e-111	409.1	Nitrospirae													Bacteria	3J0R2@40117,COG2928@1,COG2928@2	NA|NA|NA	S	Protein of unknown function (DUF502)
MAG.T21.41_02600	330214.NIDE2924	1.2e-97	362.8	Nitrospirae	tmk		2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0NI@40117,COG0125@1,COG0125@2	NA|NA|NA	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MAG.T21.41_02601	330214.NIDE2926	2.5e-165	588.2	Bacteria	holB		2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	COG2812@1,COG2812@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MAG.T21.41_02602	330214.NIDE2927	0.0	1089.7	Nitrospirae	metG	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20,6.1.1.6	ko:K01874,ko:K01890,ko:K04566,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03658,R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Bacteria	3J0AI@40117,COG0073@1,COG0073@2,COG0143@1,COG0143@2	NA|NA|NA	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAG.T21.41_02603	330214.NIDE2928	1.9e-142	511.9	Bacteria													Bacteria	2CHNQ@1,2Z7KM@2	NA|NA|NA		
MAG.T21.41_02604	1382356.JQMP01000004_gene670	1.3e-51	209.9	Thermomicrobia													Bacteria	27Y06@189775,2G6BS@200795,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T21.41_02605	1282360.ABAC460_19840	1.8e-154	552.7	Proteobacteria													Bacteria	1MWR0@1224,COG1032@1,COG1032@2	NA|NA|NA	C	SMART Elongator protein 3 MiaB NifB
MAG.T21.41_02608	330214.NIDE2581	0.0	1116.3	Bacteria													Bacteria	COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems, periplasmic component
MAG.T21.41_02609	330214.NIDE2578	7.9e-116	423.7	Bacteria													Bacteria	2F9RH@1,3421I@2	NA|NA|NA		
MAG.T21.41_02610	330214.NIDE2577	2.5e-121	442.2	Bacteria				ko:K07234					ko00000				Bacteria	COG3213@1,COG3213@2	NA|NA|NA	P	Protein involved in response to NO
MAG.T21.41_02612	330214.NIDE1303	0.0	2474.1	Nitrospirae	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	3J0CW@40117,COG0085@1,COG0085@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T21.41_02613	330214.NIDE1302	1.6e-142	512.3	Nitrospirae	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02864,ko:K02935	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0NQ@40117,COG0222@1,COG0222@2,COG0244@1,COG0244@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MAG.T21.41_02614	330214.NIDE1301	2.5e-116	424.9	Nitrospirae	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02863	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0GB@40117,COG0081@1,COG0081@2	NA|NA|NA	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MAG.T21.41_02615	330214.NIDE1300	6.2e-70	270.0	Nitrospirae	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02867	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0K2@40117,COG0080@1,COG0080@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MAG.T21.41_02616	330214.NIDE1299	4.1e-95	354.0	Nitrospirae	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601					ko00000,ko03009,ko03021				Bacteria	3J0JA@40117,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination
MAG.T21.41_02617	330214.NIDE1298	1e-24	118.6	Bacteria	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	COG0690@1,COG0690@2	NA|NA|NA	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MAG.T21.41_02619	330214.NIDE1294	1.5e-49	201.8	Nitrospirae	tuf			ko:K02358					ko00000,ko03012,ko03029,ko04147				Bacteria	3J0DG@40117,COG0050@1,COG0050@2	NA|NA|NA	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MAG.T21.41_02620	330214.NIDE1870	8.2e-10	70.1	Nitrospirae				ko:K07814					ko00000,ko02022				Bacteria	3J0ID@40117,COG3437@1,COG3437@2	NA|NA|NA	T	response regulator
MAG.T21.41_02622	330214.NIDE1868	0.0	2238.4	Nitrospirae	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	Bacteria	3J0UH@40117,COG0646@1,COG0646@2,COG1410@1,COG1410@2	NA|NA|NA	H	Pterin binding enzyme
MAG.T21.41_02623	330214.NIDE1867	1.3e-121	442.6	Bacteria													Bacteria	2FKUS@1,34CF5@2	NA|NA|NA		
MAG.T21.41_02627	330214.NIDE1862	3e-44	184.1	Nitrospirae													Bacteria	2CC8H@1,330SM@2,3J1D6@40117	NA|NA|NA		
MAG.T21.41_02628	330214.NIDE1861	1.2e-124	452.6	Bacteria			1.3.3.11	ko:K06137					ko00000,ko01000				Bacteria	COG5424@1,COG5424@2	NA|NA|NA	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
MAG.T21.41_02629	330214.NIDE1860	3e-138	498.0	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02631	391619.PGA1_c30650	6.7e-77	294.3	Alphaproteobacteria				ko:K07454					ko00000				Bacteria	1N417@1224,2UJIE@28211,COG3440@1,COG3440@2	NA|NA|NA	V	HNH endonuclease
MAG.T21.41_02632	1123360.thalar_00595	2.5e-09	68.6	Alphaproteobacteria				ko:K07454					ko00000				Bacteria	1N417@1224,2UJIE@28211,COG3440@1,COG3440@2	NA|NA|NA	V	HNH endonuclease
MAG.T21.41_02633	713587.THITH_11275	2.2e-228	798.5	Gammaproteobacteria													Bacteria	1MV08@1224,1RS4U@1236,COG3387@1,COG3387@2	NA|NA|NA	G	Glucoamylase and related glycosyl hydrolases
MAG.T21.41_02634	42256.RradSPS_0959	1.3e-137	496.5	Rubrobacteria	zwf		1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GISI@201174,4CPHW@84995,COG0364@1,COG0364@2	NA|NA|NA	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAG.T21.41_02636	1382359.JIAL01000001_gene350	1.6e-83	316.6	Bacteria	VVA0737	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659		ko:K06212,ko:K06402					ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3			Bacteria	COG0517@1,COG0517@2,COG1994@1,COG1994@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_02638	330214.NIDE3133	3.4e-122	444.5	Bacteria													Bacteria	2C8FN@1,2ZBER@2	NA|NA|NA		
MAG.T21.41_02640	330214.NIDE3134	1.7e-13	83.6	Nitrospirae													Bacteria	3J1CG@40117,COG0457@1,COG0457@2	NA|NA|NA	S	Evidence 5 No homology to any previously reported sequences
MAG.T21.41_02642	768710.DesyoDRAFT_1526	3.1e-39	168.7	Clostridia				ko:K02282					ko00000,ko02035,ko02044				Bacteria	1TSBV@1239,25BWE@186801,COG2197@1,COG2197@2	NA|NA|NA	K	PFAM Response regulator receiver domain
MAG.T21.41_02643	1191523.MROS_1245	3.2e-57	229.9	Bacteria													Bacteria	COG2202@1,COG2202@2,COG3290@1,COG3290@2,COG4585@1,COG4585@2	NA|NA|NA	T	protein histidine kinase activity
MAG.T21.41_02648	330214.NIDE3144	1.3e-80	305.8	Nitrospirae	lexA		3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	3J1C0@40117,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response)
MAG.T21.41_02649	452637.Oter_0693	2.9e-146	525.0	Verrucomicrobia	ldc		4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	46WJD@74201,COG0019@1,COG0019@2	NA|NA|NA	E	PFAM Orn DAP Arg decarboxylase 2
MAG.T21.41_02650	452637.Oter_0694	2.7e-205	721.5	Bacteria	hss		2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110		R00018	RC00053	ko00000,ko00001,ko01000				Bacteria	COG5310@1,COG5310@2	NA|NA|NA	Q	Homospermidine synthase
MAG.T21.41_02651	330214.NIDE3967	5.1e-199	700.3	Bacteria													Bacteria	COG1538@1,COG1538@2	NA|NA|NA	MU	efflux transmembrane transporter activity
MAG.T21.41_02652	330214.NIDE3968	4.8e-291	1006.5	Bacteria				ko:K02021					ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21			Bacteria	COG2274@1,COG2274@2	NA|NA|NA	V	protein secretion by the type I secretion system
MAG.T21.41_02653	330214.NIDE3970	1.6e-111	409.1	Bacteria	VVA0018												Bacteria	COG2972@1,COG2972@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_02654	330214.NIDE3971	4.6e-110	404.1	Nitrospirae	rluB		5.4.99.19,5.4.99.21,5.4.99.22	ko:K06178,ko:K06182,ko:K06183					ko00000,ko01000,ko03009				Bacteria	3J0RN@40117,COG1187@1,COG1187@2	NA|NA|NA	J	Belongs to the pseudouridine synthase RsuA family
MAG.T21.41_02655	330214.NIDE3972	2.2e-168	598.2	Bacteria	speB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0010@1,COG0010@2	NA|NA|NA	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
MAG.T21.41_02656	330214.NIDE3973	2.1e-105	388.3	Bacteria	pdaD		4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1945@1,COG1945@2	NA|NA|NA	I	arginine decarboxylase activity
MAG.T21.41_02657	330214.NIDE3974	1.3e-236	825.5	Nitrospirae			1.2.1.3,1.2.1.9	ko:K00128,ko:K00131	ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00135,M00308,M00633	R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0YN@40117,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T21.41_02659	330214.NIDE3976	3.7e-106	391.0	Bacteria													Bacteria	COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAG.T21.41_02660	330214.NIDE3977	1.4e-193	682.2	Bacteria			2.5.1.46	ko:K00809					ko00000,ko01000				Bacteria	COG1899@1,COG1899@2	NA|NA|NA	O	peptidyl-lysine modification to peptidyl-hypusine
MAG.T21.41_02661	330214.NIDE3978	5.8e-103	380.6	Bacteria				ko:K07238					ko00000,ko02000	2.A.5.5			Bacteria	COG0428@1,COG0428@2	NA|NA|NA	P	transporter
MAG.T21.41_02662	330214.NIDE3979	3.1e-155	554.7	Nitrospirae													Bacteria	3J1C8@40117,COG0500@1,COG2226@2	NA|NA|NA	H	Dimerisation domain
MAG.T21.41_02665	351016.RAZWK3B_19856	3.3e-18	99.0	Alphaproteobacteria													Bacteria	1NI66@1224,2UM4N@28211,COG0500@1,COG0500@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_02666	330214.NIDE1222	2.5e-74	284.6	Nitrospirae	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J0B7@40117,COG5000@1,COG5000@2	NA|NA|NA	T	GHKL domain
MAG.T21.41_02667	330214.NIDE1223	1.2e-242	845.5	Nitrospirae	ntrX			ko:K02481,ko:K13599	ko02020,map02020	M00498			ko00000,ko00001,ko00002,ko02022				Bacteria	3J0C2@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_02668	330214.NIDE1224	2.2e-177	628.2	Nitrospirae	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1844,iECSF_1327.ECSF_2340	Bacteria	3J0DR@40117,COG0150@1,COG0150@2	NA|NA|NA	F	AIR synthase related protein, N-terminal domain
MAG.T21.41_02669	330214.NIDE1225	3.5e-99	367.9	Nitrospirae	purN		2.1.2.2,6.3.2.6,6.3.4.13	ko:K11175,ko:K13713	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04144,R04325,R04326,R04591	RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS04225	Bacteria	3J0MC@40117,COG0299@1,COG0299@2	NA|NA|NA	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MAG.T21.41_02672	272134.KB731326_gene351	1.1e-77	297.0	Oscillatoriales			5.1.3.2	ko:K01784,ko:K20534	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.9	GT2		Bacteria	1G3KY@1117,1HBRG@1150,COG0451@1,COG0451@2	NA|NA|NA	GM	NAD dependent epimerase dehydratase family
MAG.T21.41_02673	330214.NIDE1561	1.5e-56	226.1	Bacteria													Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_02674	330214.NIDE1562	4.3e-105	387.5	Nitrospirae													Bacteria	3J11I@40117,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T21.41_02675	330214.NIDE1563	1.8e-206	725.3	Bacteria	cpxA		2.7.13.3	ko:K02484,ko:K07640,ko:K07643,ko:K07645,ko:K07649,ko:K19609	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00447,M00451,M00453,M00457,M00721,M00722,M00727,M00728,M00770			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG5002@1,COG5002@2	NA|NA|NA	T	protein histidine kinase activity
MAG.T21.41_02676	330214.NIDE1226	2.9e-27	127.9	Bacteria													Bacteria	COG2198@1,COG2198@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_02677	330214.NIDE1227	2.4e-269	934.5	Bacteria			2.7.13.3	ko:K20973	ko02020,ko02025,map02020,map02025	M00820			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG0642@1,COG0642@2,COG0784@1,COG0784@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_02678	330214.NIDE1228	1.3e-182	645.6	Nitrospirae													Bacteria	3J188@40117,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase
MAG.T21.41_02679	330214.NIDE1229	1.9e-99	368.6	Bacteria			3.1.3.3	ko:K03413,ko:K07315	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021				Bacteria	COG3437@1,COG3437@2	NA|NA|NA	T	response regulator, receiver
MAG.T21.41_02680	330214.NIDE1230	3.9e-61	241.1	Nitrospirae	yqeY			ko:K09117					ko00000				Bacteria	3J1F3@40117,COG1610@1,COG1610@2	NA|NA|NA	S	Yqey-like protein
MAG.T21.41_02682	330214.NIDE1232	3e-80	304.7	Bacteria	lacY			ko:K02532,ko:K05820,ko:K08167,ko:K08218,ko:K08369	ko01501,map01501	M00628,M00713,M00714			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.1,2.A.1.25,2.A.1.27,2.A.1.3,2.A.1.5			Bacteria	COG2807@1,COG2807@2	NA|NA|NA	P	transmembrane transport
MAG.T21.41_02685	330214.NIDE4078	9.3e-106	389.8	Bacteria				ko:K07090					ko00000				Bacteria	29802@1,2ZV65@2	NA|NA|NA		
MAG.T21.41_02689	886293.Sinac_0069	1.1e-15	91.3	Planctomycetes													Bacteria	2IZV3@203682,COG3464@1,COG3464@2	NA|NA|NA	L	PFAM Uncharacterised protein family (UPF0236)
MAG.T21.41_02690	426117.M446_0754	1.5e-11	74.7	Methylobacteriaceae				ko:K07493					ko00000				Bacteria	1JRXN@119045,1MU4P@1224,2TUQT@28211,COG3328@1,COG3328@2	NA|NA|NA	L	PFAM transposase mutator type
MAG.T21.41_02691	1089552.KI911559_gene111	9.2e-18	95.5	Rhodospirillales				ko:K07493					ko00000				Bacteria	1MU4P@1224,2JPZG@204441,2TUQT@28211,COG3328@1,COG3328@2	NA|NA|NA	L	Transposase mutator type
MAG.T21.41_02695	330214.NIDE1096	1.1e-161	576.2	Nitrospirae				ko:K19804					ko00000				Bacteria	3J0KC@40117,COG2956@1,COG2956@2	NA|NA|NA	G	Tetratricopeptide repeat
MAG.T21.41_02696	330214.NIDE1095	1.8e-179	635.2	Nitrospirae	bioB		2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000			iYO844.BSU30200	Bacteria	3J0I9@40117,COG0502@1,COG0502@2	NA|NA|NA	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MAG.T21.41_02697	330214.NIDE1094	0.0	1218.4	Nitrospirae	salY			ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	3J0Z3@40117,COG0577@1,COG0577@2	NA|NA|NA	V	MacB-like periplasmic core domain
MAG.T21.41_02698	330214.NIDE1093	3.7e-33	147.5	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_02699	330214.NIDE1091	1.3e-157	562.4	Nitrospirae	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000				Bacteria	3J145@40117,COG0167@1,COG0167@2	NA|NA|NA	F	Catalyzes the conversion of dihydroorotate to orotate
MAG.T21.41_02700	330214.NIDE1090	1.7e-101	375.6	Bacteria				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG1136@1,COG1136@2	NA|NA|NA	V	lipoprotein transporter activity
MAG.T21.41_02701	330214.NIDE1089	2.7e-106	391.7	Nitrospirae	comF		2.4.2.14	ko:K00764,ko:K02242	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00429	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002,ko02044				Bacteria	3J19P@40117,COG1040@1,COG1040@2	NA|NA|NA	S	Phosphoribosyl transferase domain
MAG.T21.41_02702	330214.NIDE1088	6.2e-36	156.8	Bacteria													Bacteria	COG2331@1,COG2331@2	NA|NA|NA	P	Regulatory protein, FmdB family
MAG.T21.41_02703	330214.NIDE1087	7.3e-74	283.1	Nitrospirae	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K03925					ko00000				Bacteria	3J0VQ@40117,COG2001@1,COG2001@2	NA|NA|NA	K	MraZ protein, putative antitoxin-like
MAG.T21.41_02704	330214.NIDE1086	3.9e-55	221.5	Bacteria	rusA		3.1.22.4	ko:K01160					ko00000,ko01000,ko03400				Bacteria	COG4570@1,COG4570@2	NA|NA|NA	L	crossover junction endodeoxyribonuclease activity
MAG.T21.41_02705	330214.NIDE1085	2.4e-186	658.3	Nitrospirae													Bacteria	3J14V@40117,COG2206@1,COG2206@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02706	330214.NIDE1084	1.9e-199	701.8	Nitrospirae	salY			ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	3J0EW@40117,COG0577@1,COG0577@2	NA|NA|NA	V	MacB-like periplasmic core domain
MAG.T21.41_02707	330214.NIDE1083	2.1e-115	421.8	Nitrospirae	macB			ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	3J10N@40117,COG1136@1,COG1136@2	NA|NA|NA	V	Evidence 2b Function of strongly homologous gene
MAG.T21.41_02708	330214.NIDE1082	1.7e-179	635.6	Nitrospirae	macA_1			ko:K02005,ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Bacteria	3J0HQ@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_02709	330214.NIDE1081	9.8e-100	369.8	Bacteria	comEA			ko:K02237		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	COG1196@1,COG1196@2,COG1555@1,COG1555@2	NA|NA|NA	L	photosystem II stabilization
MAG.T21.41_02710	330214.NIDE1080	2.6e-139	501.5	Nitrospirae	uppP	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K06153	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011			iYL1228.KPN_03461	Bacteria	3J0S7@40117,COG1968@1,COG1968@2	NA|NA|NA	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)
MAG.T21.41_02711	323848.Nmul_A2677	4.5e-10	70.5	Nitrosomonadales													Bacteria	1NP57@1224,2W4M7@28216,3320J@2,373I1@32003,arCOG08720@1	NA|NA|NA	S	Domain of unknown function (DUF2024)
MAG.T21.41_02712	330214.NIDE1078	2.1e-75	288.5	Nitrospirae	lspA		3.4.23.36	ko:K03101	ko03060,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	3J0S2@40117,COG0597@1,COG0597@2	NA|NA|NA	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MAG.T21.41_02713	330214.NIDE1077	0.0	1787.3	Nitrospirae	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_0027,iPC815.YPO0475	Bacteria	3J0BF@40117,COG0060@1,COG0060@2	NA|NA|NA	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MAG.T21.41_02714	1144275.COCOR_02848	1.6e-174	619.8	Myxococcales	hflB												Bacteria	1NF48@1224,2WMCV@28221,2YXIN@29,43BJ4@68525,COG0464@1,COG0464@2	NA|NA|NA	O	ATPase family associated with various cellular activities (AAA)
MAG.T21.41_02715	1144275.COCOR_02849	4.6e-72	279.3	Proteobacteria													Bacteria	1QY06@1224,2DUXF@1,33SVE@2	NA|NA|NA		
MAG.T21.41_02716	1125863.JAFN01000001_gene2524	7.6e-27	127.9	Deltaproteobacteria	lgt			ko:K13292					ko00000,ko01000				Bacteria	1MVE3@1224,2WNPT@28221,42M2I@68525,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MAG.T21.41_02717	1123261.AXDW01000010_gene354	1.2e-49	204.9	Bacteria													Bacteria	2C45E@1,34056@2	NA|NA|NA		
MAG.T21.41_02718	1429046.RR21198_0303	5e-12	79.0	Actinobacteria													Bacteria	2ECCY@1,2H2Q3@201174,336B7@2	NA|NA|NA		
MAG.T21.41_02720	330214.NIDE3548	5.2e-248	863.2	Nitrospirae	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Bacteria	3J0FV@40117,COG0104@1,COG0104@2	NA|NA|NA	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MAG.T21.41_02723	330214.NIDE3551	3.8e-310	1070.1	Nitrospirae				ko:K06158					ko00000,ko03012				Bacteria	3J0W6@40117,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T21.41_02725	330214.NIDE3553	3.4e-207	727.6	Nitrospirae	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K07478					ko00000				Bacteria	3J0H6@40117,COG2256@1,COG2256@2	NA|NA|NA	L	MgsA AAA+ ATPase C terminal
MAG.T21.41_02726	330214.NIDE3554	3.9e-113	414.5	Bacteria	pcaD												Bacteria	COG0596@1,COG0596@2	NA|NA|NA	S	hydrolase activity, acting on ester bonds
MAG.T21.41_02727	330214.NIDE3555	1.9e-107	395.2	Nitrospirae	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c	Bacteria	3J0Q0@40117,COG0302@1,COG0302@2	NA|NA|NA	F	GTP cyclohydrolase I
MAG.T21.41_02728	330214.NIDE3556	5.2e-67	260.4	Bacteria	ygcM		4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	COG0720@1,COG0720@2	NA|NA|NA	H	synthase
MAG.T21.41_02729	330214.NIDE3558	7.5e-52	209.5	Nitrospirae				ko:K13628,ko:K15724					ko00000,ko03016				Bacteria	3J0TZ@40117,COG0316@1,COG0316@2	NA|NA|NA	S	Belongs to the HesB IscA family
MAG.T21.41_02730	330214.NIDE3559	5.6e-56	223.4	Bacteria	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840		ko:K04755					ko00000				Bacteria	COG0633@1,COG0633@2	NA|NA|NA	C	Ferredoxin
MAG.T21.41_02731	243164.DET1472	1.9e-51	211.1	Dehalococcoidia			3.4.24.40	ko:K01406	ko01503,map01503				ko00000,ko00001,ko01000,ko01002				Bacteria	2G9X3@200795,34DP2@301297,COG3209@1,COG3209@2,COG3391@1,COG3391@2	NA|NA|NA	M	amine dehydrogenase activity
MAG.T21.41_02733	467661.RKLH11_4066	1.7e-40	172.2	unclassified Rhodobacteraceae				ko:K07497					ko00000				Bacteria	1RG0C@1224,2U7S5@28211,3ZHKU@58840,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
MAG.T21.41_02734	330214.NIDE2830	8.5e-188	664.1	Bacteria	pulQ			ko:K02453	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	COG0457@1,COG0457@2,COG4796@1,COG4796@2	NA|NA|NA	U	Type ii and iii secretion system protein
MAG.T21.41_02735	330214.NIDE2828	3.8e-34	151.0	Bacteria	oxpG			ko:K02456	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
MAG.T21.41_02739	1205680.CAKO01000002_gene3038	2e-103	383.6	Rhodospirillales				ko:K20971	ko02025,map02025				ko00000,ko00001,ko01001,ko02022				Bacteria	1RCM9@1224,2JQQV@204441,2TR8X@28211,COG4191@1,COG4191@2,COG4251@1,COG4251@2	NA|NA|NA	T	Signal transduction histidine kinase
MAG.T21.41_02740	1205680.CAKO01000002_gene2174	4.6e-20	104.4	Rhodospirillales	ptpA		3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	1RH90@1224,2JSNX@204441,2U72X@28211,COG0394@1,COG0394@2	NA|NA|NA	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAG.T21.41_02741	1123392.AQWL01000010_gene2341	1.2e-39	171.0	Betaproteobacteria	traB			ko:K12065,ko:K15051					ko00000,ko02044	3.A.7.11.1			Bacteria	1QUPW@1224,2VMWY@28216,COG2433@1,COG2433@2	NA|NA|NA	S	Bacterial conjugation TrbI-like protein
MAG.T21.41_02742	349521.HCH_01777	1.1e-27	130.6	Oceanospirillales	dsbC		5.3.4.1	ko:K03981					ko00000,ko01000,ko02044,ko03110	3.A.7.11.1			Bacteria	1RD39@1224,1S3U8@1236,1XJNT@135619,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAG.T21.41_02744	1158165.KB898873_gene372	8.4e-114	418.3	Chromatiales	traG			ko:K12063					ko00000,ko02044	3.A.7.11.1			Bacteria	1MUEN@1224,1RMMX@1236,1WXA7@135613,COG3451@1,COG3451@2	NA|NA|NA	U	TIGRFAM type-IV secretion system protein TraC
MAG.T21.41_02745	420662.Mpe_B0373	9.3e-14	83.6	Betaproteobacteria	trhF		3.4.21.89	ko:K03100,ko:K12062,ko:K13280	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002,ko02044	3.A.7.11.1			Bacteria	1R3QJ@1224,2VYNI@28216,COG0681@1,COG0681@2	NA|NA|NA	U	Belongs to the peptidase S26 family
MAG.T21.41_02746	272624.lpg2086	1e-21	111.3	Legionellales	traW			ko:K12061					ko00000,ko02044	3.A.7.11.1			Bacteria	1JCGT@118969,1N1MK@1224,1S72B@1236,2CGUX@1,31QWG@2	NA|NA|NA	S	Type-F conjugative transfer system protein TraW
MAG.T21.41_02747	91604.ID47_01355	2.5e-59	236.1	Rickettsiales	traU			ko:K12060					ko00000,ko02044	3.A.7.11.1			Bacteria	1MXUA@1224,28HGF@1,2U2HG@28211,2Z7SA@2,47EWU@766	NA|NA|NA	S	TraU protein
MAG.T21.41_02748	1454004.AW11_01152	2.9e-32	146.0	Betaproteobacteria	traF			ko:K12057					ko00000,ko02044	3.A.7.11.1			Bacteria	1MXG2@1224,2VMSV@28216,COG0526@1,COG0526@2	NA|NA|NA	CO	F plasmid transfer operon protein
MAG.T21.41_02749	216591.pBCA021	6e-26	125.6	Burkholderiaceae	traH			ko:K12072					ko00000,ko02044	3.A.7.11.1			Bacteria	1K6PW@119060,1MWD0@1224,28MTB@1,2VQE5@28216,2ZB1J@2	NA|NA|NA	S	Conjugative relaxosome accessory transposon protein
MAG.T21.41_02750	1335760.ASTG01000021_gene2817	6e-22	114.0	Sphingomonadales	traG			ko:K12056					ko00000,ko02044	3.A.7.11.1			Bacteria	1MXCR@1224,2K1QI@204457,2U372@28211,COG4678@1,COG4678@2	NA|NA|NA	G	TraG-like protein, N-terminal region
MAG.T21.41_02753	909663.KI867150_gene2751	1.2e-27	130.2	Bacteria	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02600,ko:K02945	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03009,ko03011,ko03021				Bacteria	COG0195@1,COG0195@2	NA|NA|NA	K	DNA-templated transcription, termination
MAG.T21.41_02756	706436.HMPREF9074_08785	4.6e-08	64.7	Capnocytophaga	ybjQ												Bacteria	1ES7F@1016,1I4ZC@117743,4NS20@976,COG0393@1,COG0393@2	NA|NA|NA	S	Putative heavy-metal-binding
MAG.T21.41_02757	1247963.JPHU01000016_gene1090	1.9e-24	120.2	Alphaproteobacteria	traN			ko:K12058					ko00000,ko02044	3.A.7.11.1			Bacteria	1MW96@1224,28KC1@1,2U6RW@28211,2Z9Z1@2	NA|NA|NA	S	Type-1V conjugative transfer system mating pair stabilisation
MAG.T21.41_02760	330214.NIDE2039	1.2e-75	289.7	Bacteria													Bacteria	COG1388@1,COG1388@2	NA|NA|NA	M	LysM domain
MAG.T21.41_02761	330214.NIDE2038	6.3e-171	606.7	Bacteria				ko:K04748			R00294	RC02794	ko00000	3.D.4.10			Bacteria	COG0714@1,COG0714@2	NA|NA|NA	KLT	Associated with various cellular activities
MAG.T21.41_02762	330214.NIDE2037	0.0	1119.4	Bacteria													Bacteria	COG1916@1,COG1916@2	NA|NA|NA		
MAG.T21.41_02763	330214.NIDE2036	0.0	1148.7	Nitrospirae	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	3J0W8@40117,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MAG.T21.41_02764	330214.NIDE2035	8.8e-232	809.3	Nitrospirae	gldE												Bacteria	3J0KN@40117,COG1253@1,COG1253@2	NA|NA|NA	S	Transporter associated domain
MAG.T21.41_02765	330214.NIDE2034	2.7e-107	394.8	Nitrospirae	rlpA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K03642					ko00000				Bacteria	3J0PD@40117,COG0797@1,COG0797@2	NA|NA|NA	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MAG.T21.41_02766	330214.NIDE2033	1.5e-65	255.4	Nitrospirae			1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J1DW@40117,COG4747@1,COG4747@2	NA|NA|NA	S	ACT domain
MAG.T21.41_02767	1027371.GOALK_120_00140	4.9e-19	101.7	Bacteria													Bacteria	COG2520@1,COG2520@2	NA|NA|NA	J	tRNA (guanine(37)-N(1))-methyltransferase activity
MAG.T21.41_02768	555387.C7BVA8_9CAUD	6.6e-18	97.4	Myoviridae													Viruses	4QB25@10239,4QHXG@10662,4QPAW@28883,4QUWW@35237	NA|NA|NA	S	2OG-Fe(II) oxygenase superfamily
MAG.T21.41_02769	1027371.GOALK_120_00130	3e-26	124.8	Actinobacteria													Bacteria	2BRP5@1,2GRXV@201174,32KNS@2	NA|NA|NA		
MAG.T21.41_02770	330214.NIDE3439	4.8e-72	277.3	Bacteria	pilA	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K02650	ko02020,map02020				ko00000,ko00001,ko02035,ko02044	3.A.15.2			Bacteria	COG4968@1,COG4968@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
MAG.T21.41_02772	330214.NIDE3438	1.8e-58	232.3	Bacteria	pilA	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K02650	ko02020,map02020				ko00000,ko00001,ko02035,ko02044	3.A.15.2			Bacteria	COG4968@1,COG4968@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
MAG.T21.41_02773	330214.NIDE3437	1.4e-249	869.0	Bacteria		GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K02847,ko:K13009,ko:K16705	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5			Bacteria	COG0457@1,COG0457@2,COG3307@1,COG3307@2	NA|NA|NA	M	-O-antigen
MAG.T21.41_02774	1278073.MYSTI_06367	5.1e-27	128.6	Myxococcales													Bacteria	1MZCR@1224,2WMT6@28221,2YW4K@29,42R7I@68525,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_02775	330214.NIDE3435	1.9e-154	552.0	Nitrospirae	pilH			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	3J122@40117,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T21.41_02776	292414.TM1040_3847	1.5e-36	161.4	Alphaproteobacteria	avxIA												Bacteria	1MU7T@1224,2TRVY@28211,COG1404@1,COG1404@2,COG2931@1,COG2931@2,COG4935@1,COG4935@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T21.41_02778	330214.NIDE2223	3e-176	624.8	Bacteria													Bacteria	28PII@1,2ZC8H@2	NA|NA|NA	S	Protein of unknown function (DUF4255)
MAG.T21.41_02779	330214.NIDE2224	1.4e-206	726.1	Bacteria			3.6.4.6	ko:K06027	ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962				ko00000,ko00001,ko01000,ko04131	1.F.1.1			Bacteria	COG0464@1,COG0464@2	NA|NA|NA	O	ATPase activity
MAG.T21.41_02781	330214.NIDE2226	1.3e-223	782.3	Bacteria													Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_02782	330214.NIDE2227	2.3e-39	169.1	Bacteria													Bacteria	COG3409@1,COG3409@2	NA|NA|NA	M	Peptidoglycan-binding domain 1 protein
MAG.T21.41_02783	330214.NIDE2226	2.7e-38	167.5	Bacteria													Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_02784	330214.NIDE2228	1.2e-127	463.8	Bacteria													Bacteria	COG2885@1,COG2885@2	NA|NA|NA	M	chlorophyll binding
MAG.T21.41_02785	330214.NIDE2229	3.5e-104	384.4	Bacteria													Bacteria	2CI52@1,2ZC5H@2	NA|NA|NA		
MAG.T21.41_02786	330214.NIDE2230	3.6e-55	220.7	Bacteria	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896											Bacteria	COG1652@1,COG1652@2	NA|NA|NA	S	positive regulation of growth rate
MAG.T21.41_02787	330214.NIDE2231	7.9e-189	666.4	Bacteria				ko:K06905					ko00000				Bacteria	COG3500@1,COG3500@2	NA|NA|NA		
MAG.T21.41_02788	330214.NIDE2232	1.2e-94	352.4	Bacteria													Bacteria	COG3501@1,COG3501@2	NA|NA|NA	T	Rhs element vgr protein
MAG.T21.41_02789	330214.NIDE2233	6.6e-48	196.4	Bacteria													Bacteria	2CE1N@1,32RYY@2	NA|NA|NA		
MAG.T21.41_02790	330214.NIDE2234	8.3e-47	193.0	Bacteria				ko:K06903					ko00000				Bacteria	COG3628@1,COG3628@2	NA|NA|NA		
MAG.T21.41_02791	330214.NIDE2235	0.0	1361.7	Bacteria	yqbT1												Bacteria	COG3299@1,COG3299@2	NA|NA|NA	S	Baseplate J-like protein
MAG.T21.41_02792	330214.NIDE2236	0.0	1358.6	Bacteria													Bacteria	COG2375@1,COG2375@2	NA|NA|NA	P	cellular response to nickel ion
MAG.T21.41_02793	330214.NIDE2237	0.0	1272.7	Bacteria													Bacteria	COG3292@1,COG3292@2	NA|NA|NA		
MAG.T21.41_02796	330214.NIDE0846	4.7e-213	746.9	Nitrospirae	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0A4@40117,COG0192@1,COG0192@2	NA|NA|NA	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MAG.T21.41_02797	330214.NIDE0845	4.5e-225	786.9	Nitrospirae	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147				Bacteria	3J0AH@40117,COG0499@1,COG0499@2	NA|NA|NA	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MAG.T21.41_02798	330214.NIDE0843	2.1e-299	1034.2	Nitrospirae													Bacteria	3J18Y@40117,COG1032@1,COG1032@2	NA|NA|NA	C	B12 binding domain
MAG.T21.41_02799	1123368.AUIS01000019_gene1217	1.3e-63	250.0	Gammaproteobacteria													Bacteria	1R5GU@1224,1SIPM@1236,COG2220@1,COG2220@2	NA|NA|NA	S	Zn-dependent hydrolases of the beta-lactamase fold
MAG.T21.41_02800	330214.NIDE0841	2.1e-152	545.0	Nitrospirae	sucD		6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0WZ@40117,COG0074@1,COG0074@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAG.T21.41_02801	330214.NIDE0840	5.7e-206	723.4	Nitrospirae	sucC		6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0ZB@40117,COG0045@1,COG0045@2	NA|NA|NA	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MAG.T21.41_02802	330214.NIDE0839	2.4e-292	1010.7	Nitrospirae			1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0WB@40117,COG0029@1,COG0029@2	NA|NA|NA	C	FAD binding domain
MAG.T21.41_02803	330214.NIDE0838	1.3e-133	482.3	Nitrospirae													Bacteria	3J11C@40117,COG1152@1,COG1152@2	NA|NA|NA	C	4Fe-4S ferredoxin iron-sulfur binding domain protein
MAG.T21.41_02804	330214.NIDE0837	0.0	1270.8	Bacteria	icd		1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG2838@1,COG2838@2	NA|NA|NA	C	Isocitrate dehydrogenase
MAG.T21.41_02805	330214.NIDE0836	0.0	1388.6	Nitrospirae	acnA		4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0E6@40117,COG1048@1,COG1048@2	NA|NA|NA	C	Aconitase C-terminal domain
MAG.T21.41_02806	330214.NIDE0835	0.0	1114.4	Bacteria			2.3.3.8,6.2.1.5	ko:K01902,ko:K15230,ko:K15233	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00352,R00405,R01322,R02404	RC00004,RC00014,RC00067	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0306	Bacteria	COG0074@1,COG0074@2,COG0372@1,COG0372@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAG.T21.41_02807	330214.NIDE0834	5.2e-207	726.9	Nitrospirae			2.3.3.8,6.2.1.18	ko:K15231,ko:K15232	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352,R01322	RC00004,RC00014,RC00067	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0305	Bacteria	3J185@40117,COG0045@1,COG0045@2	NA|NA|NA	H	ATP citrate lyase citrate-binding
MAG.T21.41_02808	330214.NIDE0833	1.4e-113	416.0	Nitrospirae	fpg		3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	3J17X@40117,COG0266@1,COG0266@2	NA|NA|NA	L	Formamidopyrimidine-DNA glycosylase H2TH domain
MAG.T21.41_02811	330214.NIDE3473	3.5e-242	844.0	Nitrospirae	oprM			ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2			Bacteria	3J0N2@40117,COG1538@1,COG1538@2	NA|NA|NA	M	Evidence 2b Function of strongly homologous gene
MAG.T21.41_02812	330214.NIDE3474	0.0	1864.7	Nitrospirae				ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2			Bacteria	3J0FA@40117,COG0841@1,COG0841@2	NA|NA|NA	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAG.T21.41_02813	330214.NIDE3475	1.6e-168	599.0	Nitrospirae				ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6			Bacteria	3J10X@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_02815	330214.NIDE3478	7.4e-77	293.5	Bacteria													Bacteria	29IJ4@1,313M6@2	NA|NA|NA	S	Protein of unknown function (DUF1579)
MAG.T21.41_02816	105422.BBPM01000006_gene6022	7.6e-41	173.3	Actinobacteria				ko:K07032					ko00000				Bacteria	2IKVS@201174,COG3607@1,COG3607@2	NA|NA|NA	S	glyoxalase bleomycin resistance protein dioxygenase
MAG.T21.41_02817	452637.Oter_1314	5.6e-40	170.2	Opitutae	ybaA		3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147				Bacteria	3K9QM@414999,46VQ8@74201,COG5507@1,COG5507@2	NA|NA|NA	S	Protein of unknown function (DUF1428)
MAG.T21.41_02818	330214.NIDE3479	1.4e-58	232.3	Bacteria													Bacteria	COG3795@1,COG3795@2	NA|NA|NA	F	YCII-related domain
MAG.T21.41_02819	330214.NIDE3481	8e-32	142.9	Bacteria			2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122		R07459,R07461	RC00043	ko00000,ko00001,ko01000				Bacteria	COG1977@1,COG1977@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T21.41_02820	330214.NIDE3482	3e-199	701.0	Bacteria													Bacteria	COG4447@1,COG4447@2	NA|NA|NA	S	cellulose binding
MAG.T21.41_02821	330214.NIDE3483	7.6e-45	186.4	Bacteria													Bacteria	COG3795@1,COG3795@2	NA|NA|NA	F	YCII-related domain
MAG.T21.41_02822	330214.NIDE3484	2.3e-46	191.4	Bacteria													Bacteria	COG3795@1,COG3795@2	NA|NA|NA	F	YCII-related domain
MAG.T21.41_02823	330214.NIDE3485	2.5e-23	114.4	Bacteria				ko:K06996					ko00000				Bacteria	COG3324@1,COG3324@2	NA|NA|NA	E	translation initiation factor activity
MAG.T21.41_02824	330214.NIDE3487	5.8e-164	583.9	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG4941@1,COG4941@2	NA|NA|NA	K	sigma factor activity
MAG.T21.41_02825	330214.NIDE3488	2.2e-43	181.4	Bacteria				ko:K02612	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001				Bacteria	COG2151@1,COG2151@2	NA|NA|NA	L	metal-sulfur cluster biosynthetic enzyme
MAG.T21.41_02826	330214.NIDE3489	1.7e-156	558.9	Bacteria			1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG4243@1,COG4243@2	NA|NA|NA	S	quinone binding
MAG.T21.41_02827	330214.NIDE3490	9.2e-58	229.9	Bacteria													Bacteria	COG5592@1,COG5592@2	NA|NA|NA	I	hemerythrin HHE cation binding domain
MAG.T21.41_02828	330214.NIDE3491	1.7e-231	808.5	Nitrospirae	oprM			ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2			Bacteria	3J0N2@40117,COG1538@1,COG1538@2	NA|NA|NA	M	Evidence 2b Function of strongly homologous gene
MAG.T21.41_02830	330214.NIDE3493	0.0	1796.6	Bacteria	acrB			ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2			Bacteria	COG0841@1,COG0841@2	NA|NA|NA	V	transmembrane transporter activity
MAG.T21.41_02831	330214.NIDE3494	1.8e-145	522.3	Bacteria				ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_02833	330214.NIDE3495	1.6e-145	522.3	Bacteria			1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000				Bacteria	COG3793@1,COG3793@2	NA|NA|NA	P	PFAM Mo-dependent nitrogenase
MAG.T21.41_02834	330214.NIDE3496	1.2e-83	316.2	Nitrospirae	dedA_2												Bacteria	3J1E4@40117,COG0586@1,COG0586@2,COG0607@1,COG0607@2	NA|NA|NA	P	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_02835	391587.KAOT1_15217	9.7e-43	180.6	Bacteria													Bacteria	2DMPM@1,32SWT@2	NA|NA|NA		
MAG.T21.41_02837	330214.NIDE2615	8.8e-38	162.5	Bacteria				ko:K18830					ko00000,ko02048,ko03000				Bacteria	COG1396@1,COG1396@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_02838	330214.NIDE2614	1.7e-44	184.9	Bacteria				ko:K06218,ko:K07334					ko00000,ko02048				Bacteria	COG2026@1,COG2026@2	NA|NA|NA	DJ	nuclease activity
MAG.T21.41_02839	330214.NIDE2613	2.5e-216	758.1	Nitrospirae	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464		ko:K03665					ko00000,ko03009				Bacteria	3J0AE@40117,COG2262@1,COG2262@2	NA|NA|NA	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MAG.T21.41_02840	1303518.CCALI_00699	1.5e-107	396.4	Bacteria													Bacteria	COG4320@1,COG4320@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2252)
MAG.T21.41_02841	330214.NIDE2619	1e-55	223.0	Bacteria													Bacteria	COG2453@1,COG2453@2	NA|NA|NA	T	phosphatase
MAG.T21.41_02845	330214.NIDE2603	1.3e-118	432.6	Bacteria			1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000				Bacteria	COG0426@1,COG0426@2	NA|NA|NA	C	nitric oxide reductase activity
MAG.T21.41_02847	330214.NIDE2599	1.5e-118	432.6	Bacteria	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.11.1.10,2.1.1.197,3.1.1.85,3.3.2.9	ko:K00433,ko:K01253,ko:K02169,ko:K02170	ko00780,ko00980,ko01100,ko04976,ko05204,map00780,map00980,map01100,map04976,map05204	M00572	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443,R09543,R09725	RC00003,RC00460,RC00461,RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko00002,ko01000,ko01002			iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155	Bacteria	COG0596@1,COG0596@2	NA|NA|NA	S	hydrolase activity, acting on ester bonds
MAG.T21.41_02850	330214.NIDE2595	1.8e-102	379.0	Bacteria	rluE	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181					ko00000,ko01000,ko03009				Bacteria	COG1187@1,COG1187@2	NA|NA|NA	J	pseudouridine synthase activity
MAG.T21.41_02851	330214.NIDE2593	3.5e-51	207.6	Bacteria													Bacteria	2DCFZ@1,2ZDZV@2	NA|NA|NA		
MAG.T21.41_02852	330214.NIDE2591	7.6e-156	557.0	Bacteria	hemY												Bacteria	COG1232@1,COG1232@2	NA|NA|NA	H	protoporphyrinogen oxidase activity
MAG.T21.41_02853	330214.NIDE2590	2.3e-27	128.6	Bacteria				ko:K07126					ko00000				Bacteria	COG0790@1,COG0790@2	NA|NA|NA	S	beta-lactamase activity
MAG.T21.41_02854	330214.NIDE2589	5.2e-68	263.8	Nitrospirae	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	3J0RI@40117,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MAG.T21.41_02855	330214.NIDE2588	1.9e-71	275.4	Bacteria				ko:K03567	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	COG2716@1,COG2716@2	NA|NA|NA	E	regulation of RNA biosynthetic process
MAG.T21.41_02856	330214.NIDE2587	5.2e-194	683.7	Bacteria	hrpB		3.6.4.13	ko:K03579					ko00000,ko01000				Bacteria	COG1643@1,COG1643@2	NA|NA|NA	L	helicase activity
MAG.T21.41_02857	330214.NIDE4265	7.8e-304	1049.3	Nitrospirae	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12137,ko:K15828					ko00000,ko01000			iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEKO11_1354.EKO11_1252,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330	Bacteria	3J0HR@40117,COG0651@1,COG0651@2	NA|NA|NA	CP	Proton-conducting membrane transporter
MAG.T21.41_02858	330214.NIDE4264	2.7e-142	511.5	Nitrospirae	hycD												Bacteria	3J0RR@40117,COG0650@1,COG0650@2	NA|NA|NA	C	NADH dehydrogenase
MAG.T21.41_02859	330214.NIDE4263	3.2e-97	361.3	Nitrospirae	hyfE	GO:0008150,GO:0040007		ko:K12140					ko00000,ko01000				Bacteria	3J166@40117,COG4237@1,COG4237@2	NA|NA|NA	C	Hydrogenase 4 membrane
MAG.T21.41_02860	330214.NIDE4262	2.8e-237	827.8	Nitrospirae	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12141					ko00000,ko01000			iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Bacteria	3J0PA@40117,COG0651@1,COG0651@2	NA|NA|NA	CP	Proton-conducting membrane transporter
MAG.T21.41_02861	330214.NIDE4261	4.8e-264	916.8	Nitrospirae	hycE		1.6.5.3	ko:K00332,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0W2@40117,COG0852@1,COG0852@2,COG3261@1,COG3261@2	NA|NA|NA	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit
MAG.T21.41_02862	330214.NIDE4260	1.7e-77	295.4	Nitrospirae													Bacteria	3J0NM@40117,COG3260@1,COG3260@2	NA|NA|NA	C	NADH ubiquinone oxidoreductase, 20 Kd subunit
MAG.T21.41_02863	330214.NIDE3948	8.2e-123	447.2	Bacteria													Bacteria	2CB8G@1,2Z88H@2	NA|NA|NA	S	Putative beta-barrel porin-2, OmpL-like. bbp2
MAG.T21.41_02864	330214.NIDE4258	7.4e-108	396.7	Bacteria													Bacteria	2E4EY@1,32ZA4@2	NA|NA|NA		
MAG.T21.41_02865	330214.NIDE4258	9.8e-31	140.6	Bacteria													Bacteria	2E4EY@1,32ZA4@2	NA|NA|NA		
MAG.T21.41_02866	330214.NIDE4257	1.6e-137	495.7	Nitrospirae	glxR		1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100		R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000			iJN678.mmsB	Bacteria	3J0R5@40117,COG2084@1,COG2084@2	NA|NA|NA	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MAG.T21.41_02868	330214.NIDE4254	1.2e-244	852.0	Bacteria													Bacteria	COG0624@1,COG0624@2	NA|NA|NA	E	succinyl-diaminopimelate desuccinylase activity
MAG.T21.41_02869	330214.NIDE4252	8.9e-181	639.4	Bacteria	aniA		1.16.3.3,1.7.2.1	ko:K00368,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_02870	330214.NIDE4251	1.4e-171	609.0	Nitrospirae	adhC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.1	ko:K13953,ko:K13979	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	3J0Y9@40117,COG1064@1,COG1064@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T21.41_02871	886377.Murru_2564	9.4e-10	70.1	Flavobacteriia	MA20_36130												Bacteria	1I2PC@117743,2DMHT@1,32RN3@2,4NPZK@976	NA|NA|NA	S	PEGA domain
MAG.T21.41_02873	330214.NIDE4247	3.5e-45	188.0	Nitrospirae				ko:K00406,ko:K12263	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	3J1AX@40117,COG2010@1,COG2010@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02874	330214.NIDE4246	1.2e-40	172.2	Bacteria													Bacteria	COG5662@1,COG5662@2	NA|NA|NA	K	AntiSigma factor
MAG.T21.41_02875	330214.NIDE4245	8.9e-97	359.8	Nitrospirae				ko:K03088					ko00000,ko03021				Bacteria	3J1A1@40117,COG1595@1,COG1595@2	NA|NA|NA	K	Belongs to the sigma-70 factor family. ECF subfamily
MAG.T21.41_02877	330214.NIDE4242	7.5e-92	343.2	Nitrospirae	der			ko:K03977					ko00000,ko03009				Bacteria	3J0G3@40117,COG1160@1,COG1160@2	NA|NA|NA	S	GTPase that plays an essential role in the late steps of ribosome biogenesis
MAG.T21.41_02878	870187.Thini_2406	3.2e-42	178.3	Gammaproteobacteria	porA		1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1MVM0@1224,1RNNX@1236,COG0674@1,COG0674@2	NA|NA|NA	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MAG.T21.41_02879	345341.KUTG_00476	5.8e-135	487.3	Bacteria	porB		1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG1013@1,COG1013@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
MAG.T21.41_02880	1454004.AW11_01657	2.8e-203	714.9	Betaproteobacteria	preT		1.2.7.1	ko:K00171,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1MU2H@1224,2VM9R@28216,COG0493@1,COG0493@2,COG1144@1,COG1144@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase
MAG.T21.41_02881	118168.MC7420_3431	5.1e-20	104.4	Oscillatoriales													Bacteria	1G896@1117,1HC6D@1150,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T21.41_02882	478741.JAFS01000002_gene551	0.0	1190.3	unclassified Verrucomicrobia	ppsA		2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	37FY0@326457,46SVA@74201,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
MAG.T21.41_02883	1459636.NTE_01678	7.1e-111	407.5	Thaumarchaeota	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147				Archaea	41SMB@651137,COG0126@1,arCOG00496@2157	NA|NA|NA	G	Phosphoglycerate kinase
MAG.T21.41_02884	1156919.QWC_20802	2.8e-121	441.8	Betaproteobacteria			1.2.1.12,1.2.1.59,1.4.1.16	ko:K00134,ko:K00150,ko:K03340	ko00010,ko00300,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00300,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00526,M00552	R01061,R01063,R02755	RC00006,RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	1N2N1@1224,2VNRF@28216,COG0057@1,COG0057@2	NA|NA|NA	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type II
MAG.T21.41_02885	330214.NIDE3590	1.1e-35	155.6	Bacteria													Bacteria	COG1664@1,COG1664@2	NA|NA|NA	M	Polymer-forming cytoskeletal
MAG.T21.41_02886	330214.NIDE3589	2e-173	615.1	Nitrospirae		GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Bacteria	3J0SZ@40117,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T21.41_02887	330214.NIDE3588	4.1e-96	357.5	Bacteria				ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	COG4191@1,COG4191@2	NA|NA|NA	T	Histidine kinase
MAG.T21.41_02888	330214.NIDE3587	0.0	1410.6	Bacteria			2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG3850@1,COG3850@2,COG4191@1,COG4191@2	NA|NA|NA	T	phosphorelay sensor kinase activity
MAG.T21.41_02889	330214.NIDE3586	5.3e-163	580.5	Bacteria			2.7.8.33,2.7.8.35	ko:K02851			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	COG1086@1,COG1086@2,COG4191@1,COG4191@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_02890	330214.NIDE3585	1.1e-71	276.2	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_02891	330214.NIDE3584	1.2e-42	179.1	Bacteria													Bacteria	2DGQ2@1,2ZWWE@2	NA|NA|NA		
MAG.T21.41_02892	330214.NIDE3583	2.7e-30	137.5	Bacteria	bolA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576		ko:K05527,ko:K22066					ko00000,ko03000,ko03029				Bacteria	COG0271@1,COG0271@2	NA|NA|NA	T	Belongs to the BolA IbaG family
MAG.T21.41_02893	330214.NIDE3582	6.2e-54	216.5	Bacteria	grxD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K07390					ko00000,ko03029,ko03110			iPC815.YPO2383,iYL1228.KPN_01992	Bacteria	COG0278@1,COG0278@2	NA|NA|NA	O	protein disulfide oxidoreductase activity
MAG.T21.41_02894	330214.NIDE3581	2.7e-218	764.6	Bacteria													Bacteria	COG0382@1,COG0382@2,COG0560@1,COG0560@2	NA|NA|NA	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MAG.T21.41_02895	649638.Trad_1872	9.2e-45	187.2	Deinococcus-Thermus													Bacteria	1WIJC@1297,COG1028@1,COG1028@2	NA|NA|NA	IQ	Short-chain dehydrogenase reductase SDR
MAG.T21.41_02896	330214.NIDE3579	3.3e-114	417.9	Bacteria				ko:K09931					ko00000				Bacteria	COG3222@1,COG3222@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2064)
MAG.T21.41_02900	330214.NIDE3575	2.5e-206	724.5	Nitrospirae	dcd		3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0WG@40117,COG0717@1,COG0717@2	NA|NA|NA	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)
MAG.T21.41_02901	330214.NIDE3574	2.1e-213	748.0	Nitrospirae	kamA		5.4.3.2	ko:K01843	ko00310,map00310		R00461	RC00303	ko00000,ko00001,ko01000				Bacteria	3J0W3@40117,COG1509@1,COG1509@2	NA|NA|NA	C	Lysine-2,3-aminomutase
MAG.T21.41_02902	330214.NIDE3573	3e-37	160.6	Bacteria			2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	COG0625@1,COG0625@2	NA|NA|NA	O	glutathione transferase activity
MAG.T21.41_02903	330214.NIDE3572	6.2e-243	846.7	Nitrospirae													Bacteria	28MGX@1,2ZATZ@2,3J0YU@40117	NA|NA|NA		
MAG.T21.41_02904	330214.NIDE3571	9.2e-209	733.0	Bacteria				ko:K01163,ko:K06940					ko00000				Bacteria	COG0727@1,COG0727@2,COG4866@1,COG4866@2	NA|NA|NA	S	Uncharacterised conserved protein (DUF2156)
MAG.T21.41_02905	330214.NIDE3570	0.0	1915.6	Nitrospirae			2.7.13.3	ko:K11527					ko00000,ko01000,ko01001,ko02022				Bacteria	3J10H@40117,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02906	330214.NIDE3569	4.9e-143	513.8	Bacteria	norQ			ko:K04748			R00294	RC02794	ko00000	3.D.4.10			Bacteria	COG0714@1,COG0714@2	NA|NA|NA	KLT	Associated with various cellular activities
MAG.T21.41_02907	153948.NAL212_1927	5e-07	61.2	Nitrosomonadales													Bacteria	1N56Z@1224,2C8BN@1,2W56V@28216,32RKS@2,373EQ@32003	NA|NA|NA	S	Glycine-zipper domain
MAG.T21.41_02908	330214.NIDE3566	6.6e-159	567.0	Nitrospirae													Bacteria	3J1BG@40117,COG2234@1,COG2234@2	NA|NA|NA	S	Peptidase family M28
MAG.T21.41_02909	330214.NIDE3565	4.5e-71	273.9	Bacteria	ftrC	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	1.8.7.2	ko:K17892					ko00000,ko01000				Bacteria	COG4802@1,COG4802@2	NA|NA|NA	C	ferredoxin-thioredoxin reductase activity
MAG.T21.41_02910	330214.NIDE3564	0.0	1446.0	Bacteria				ko:K02448			R00294	RC02794	ko00000	3.D.4.10			Bacteria	COG4548@1,COG4548@2	NA|NA|NA	P	von Willebrand factor (vWF) type A domain
MAG.T21.41_02911	330214.NIDE3563	3e-69	267.7	Bacteria													Bacteria	2DESJ@1,2ZP2P@2	NA|NA|NA		
MAG.T21.41_02912	330214.NIDE3562	1e-157	562.8	Nitrospirae	mdh		1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0EG@40117,COG0039@1,COG0039@2	NA|NA|NA	C	Catalyzes the reversible oxidation of malate to oxaloacetate
MAG.T21.41_02913	330214.NIDE3561	1.5e-103	382.1	Nitrospirae													Bacteria	3J19B@40117,COG3748@1,COG3748@2	NA|NA|NA	S	Pfam:DUF989
MAG.T21.41_02915	85643.Tmz1t_2112	2.7e-293	1013.8	Rhodocyclales													Bacteria	1MUIU@1224,2KXCU@206389,2VI8A@28216,COG4644@1,COG4644@2	NA|NA|NA	L	PFAM transposase Tn3 family protein
MAG.T21.41_02916	65497.JODV01000002_gene4158	4e-55	221.9	Pseudonocardiales	ksgA		2.1.1.182,2.1.1.184	ko:K00561,ko:K02528			R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009				Bacteria	2H1TK@201174,4DXHF@85010,COG0030@1,COG0030@2	NA|NA|NA	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family
MAG.T21.41_02918	330214.NIDE3921	4.6e-112	411.0	Bacteria													Bacteria	29TFP@1,30ENV@2	NA|NA|NA		
MAG.T21.41_02919	330214.NIDE3914	2.2e-54	218.0	Bacteria													Bacteria	COG0662@1,COG0662@2	NA|NA|NA	G	Cupin 2, conserved barrel domain protein
MAG.T21.41_02920	330214.NIDE3913	2.2e-235	821.6	Bacteria													Bacteria	COG1807@1,COG1807@2	NA|NA|NA	M	4-amino-4-deoxy-L-arabinose transferase activity
MAG.T21.41_02921	330214.NIDE3912	9e-61	239.6	Bacteria													Bacteria	COG4244@1,COG4244@2	NA|NA|NA	E	Membrane
MAG.T21.41_02922	330214.NIDE3911	3.4e-78	298.9	Bacteria													Bacteria	COG1664@1,COG1664@2	NA|NA|NA	M	Polymer-forming cytoskeletal
MAG.T21.41_02923	330214.NIDE3909	3.7e-154	551.2	Bacteria	iamB			ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	COG0767@1,COG0767@2	NA|NA|NA	Q	ABC-type transport system involved in resistance to organic solvents, permease component
MAG.T21.41_02925	330214.NIDE3908	3.2e-120	438.0	Nitrospirae	iamA			ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J0J2@40117,COG1127@1,COG1127@2	NA|NA|NA	Q	ABC transporter
MAG.T21.41_02926	330214.NIDE3907	3.8e-123	448.0	Bacteria	iamC			ko:K02067	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	COG1463@1,COG1463@2	NA|NA|NA	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAG.T21.41_02927	330214.NIDE3906	2.3e-68	265.4	Bacteria				ko:K18480		M00669			ko00000,ko00002,ko02000	3.A.1.27.1			Bacteria	COG3218@1,COG3218@2	NA|NA|NA	Q	ABC-type transport auxiliary lipoprotein component
MAG.T21.41_02928	330214.NIDE3905	1.5e-64	252.3	Bacteria													Bacteria	COG1814@1,COG1814@2	NA|NA|NA	S	cellular manganese ion homeostasis
MAG.T21.41_02929	330214.NIDE3904	2.3e-221	774.6	Nitrospirae	treT		2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100		R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000		GT4		Bacteria	3J0Z0@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_02930	330214.NIDE3903	7.8e-305	1052.4	Nitrospirae	glgP		2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35		Bacteria	3J0W1@40117,COG0058@1,COG0058@2	NA|NA|NA	G	Carbohydrate phosphorylase
MAG.T21.41_02933	330214.NIDE3821	1.3e-51	210.3	Bacteria	manC		2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0836@1,COG0836@2	NA|NA|NA	M	mannose-1-phosphate guanylyltransferase activity
MAG.T21.41_02934	330214.NIDE3897	1.9e-138	498.8	Nitrospirae	mntH			ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3			Bacteria	3J1A7@40117,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
MAG.T21.41_02935	330214.NIDE3896	3.8e-64	250.8	Bacteria	rnk			ko:K03624,ko:K06140					ko00000,ko03000,ko03021				Bacteria	COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MAG.T21.41_02936	330214.NIDE3895	1.8e-64	251.9	Bacteria	ymaD			ko:K04063					ko00000				Bacteria	COG1764@1,COG1764@2	NA|NA|NA	O	response to oxidative stress
MAG.T21.41_02937	330214.NIDE3893	2.9e-31	141.4	Bacteria				ko:K12263					ko00000				Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02938	330214.NIDE3892	2.1e-66	258.5	Bacteria													Bacteria	2ED3M@1,3370H@2	NA|NA|NA		
MAG.T21.41_02939	665571.STHERM_c01710	3e-07	60.8	Bacteria													Bacteria	2EGD6@1,33A4Z@2	NA|NA|NA	S	Protein of unknown function (DUF2892)
MAG.T21.41_02940	330214.NIDE3231	9.4e-37	159.8	Bacteria				ko:K09137					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_02941	330214.NIDE3890	3.1e-77	294.7	Nitrospirae			1.3.5.1,1.3.5.4	ko:K00240,ko:K03886	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00151,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0TT@40117,COG0723@1,COG0723@2	NA|NA|NA	C	Rieske [2Fe-2S] domain
MAG.T21.41_02942	330214.NIDE3889	3e-240	837.4	Nitrospirae	qcrC			ko:K00412,ko:K03888	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152			ko00000,ko00001,ko00002,ko03029				Bacteria	3J0Q6@40117,COG1290@1,COG1290@2,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome b/b6/petB
MAG.T21.41_02943	330214.NIDE3882	5.4e-23	114.8	Bacteria				ko:K12263					ko00000				Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02944	330214.NIDE3888	8.1e-42	176.4	Bacteria				ko:K12263					ko00000				Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_02945	330214.NIDE3887	4.4e-90	337.4	Bacteria													Bacteria	COG0840@1,COG0840@2	NA|NA|NA	NT	transmembrane signaling receptor activity
MAG.T21.41_02946	1205680.CAKO01000026_gene4530	1.5e-31	142.5	Alphaproteobacteria			3.2.1.73,3.4.16.4,3.4.24.40,4.2.2.3	ko:K01216,ko:K01286,ko:K01406,ko:K01729,ko:K09005	ko00051,ko01503,map00051,map01503		R03706		ko00000,ko00001,ko01000,ko01002				Bacteria	1RANY@1224,2U62W@28211,COG2273@1,COG2273@2,COG2931@1,COG2931@2	NA|NA|NA	G	Beta-glucanase Beta-glucan synthetase
MAG.T21.41_02949	1179773.BN6_47750	1.5e-52	213.8	Pseudonocardiales													Bacteria	2IEI0@201174,4E86U@85010,COG0500@1,COG2226@2	NA|NA|NA	Q	Domain of unknown function (DUF4214)
MAG.T21.41_02950	590409.Dd586_1744	8.3e-42	177.9	Gammaproteobacteria													Bacteria	1RDQ4@1224,1S45C@1236,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase family
MAG.T21.41_02952	322710.Avin_03870	1.3e-21	109.8	Gammaproteobacteria	fecI12		5.2.1.8	ko:K03088,ko:K03769					ko00000,ko01000,ko03021,ko03110				Bacteria	1N1F5@1224,1SAR2@1236,COG1595@1,COG1595@2	NA|NA|NA	K	Belongs to the sigma-70 factor family. ECF subfamily
MAG.T21.41_02953	640081.Dsui_2974	2.6e-129	468.8	Rhodocyclales													Bacteria	1MXGY@1224,2KWIX@206389,2VKZZ@28216,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_02954	870187.Thini_3576	7.8e-20	102.8	Bacteria			3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000				Bacteria	COG4118@1,COG4118@2	NA|NA|NA	D	positive regulation of growth
MAG.T21.41_02955	671143.DAMO_0789	5.5e-41	173.7	unclassified Bacteria													Bacteria	2NRIX@2323,COG3744@1,COG3744@2	NA|NA|NA	S	PIN domain
MAG.T21.41_02966	1122214.AQWH01000017_gene4633	4.9e-94	350.5	Alphaproteobacteria	hin												Bacteria	1MW94@1224,2TUFN@28211,COG1961@1,COG1961@2	NA|NA|NA	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MAG.T21.41_02967	318586.Pden_5036	1.5e-111	409.5	Paracoccus				ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	1NKYF@1224,2PUBW@265,2U4CE@28211,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
MAG.T21.41_02968	935848.JAEN01000013_gene4097	3.3e-193	681.0	Paracoccus	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	1MVJU@1224,2PWGT@265,2TRYQ@28211,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T21.41_02969	935848.JAEN01000013_gene4096	2.7e-154	551.6	Paracoccus													Bacteria	1R89X@1224,2PWES@265,2U4QC@28211,COG5527@1,COG5527@2	NA|NA|NA	L	Initiator Replication protein
MAG.T21.41_02972	1446473.JHWH01000004_gene2711	3.1e-27	128.6	Paracoccus													Bacteria	1MXM8@1224,2PUYP@265,2TTJ3@28211,COG5448@1,COG5448@2	NA|NA|NA	S	Conserved hypothetical protein 2217 (DUF2460)
MAG.T21.41_02975	330214.NIDE4192	1.1e-174	619.4	Nitrospirae													Bacteria	3J19Q@40117,COG4783@1,COG4783@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_02976	330214.NIDE4194	3.6e-120	437.6	Bacteria	WQ51_05710												Bacteria	COG2013@1,COG2013@2	NA|NA|NA	S	Mitochondrial biogenesis AIM24
MAG.T21.41_02977	1121413.JMKT01000008_gene1088	2.4e-08	65.1	Desulfovibrionales													Bacteria	1NJ9J@1224,2EN8Q@1,2MBRD@213115,2WT2P@28221,33FWH@2,42XE1@68525	NA|NA|NA		
MAG.T21.41_02978	330214.NIDE4196	1.1e-142	512.7	Nitrospirae													Bacteria	3J0NC@40117,COG1639@1,COG1639@2	NA|NA|NA	T	HDOD domain
MAG.T21.41_02980	247490.KSU1_C1141	3.6e-27	128.3	Bacteria													Bacteria	COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_02984	330214.NIDE4013	8.7e-61	239.6	Bacteria													Bacteria	2EQ22@1,33HNG@2	NA|NA|NA		
MAG.T21.41_02985	330214.NIDE4014	9.2e-201	706.1	Bacteria													Bacteria	2EUIU@1,33N0V@2	NA|NA|NA		
MAG.T21.41_02986	1105367.CG50_00830	2.8e-95	355.9	Alphaproteobacteria													Bacteria	1MW8M@1224,2TUSJ@28211,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_02987	1105367.CG50_00835	2.4e-17	94.0	Alphaproteobacteria													Bacteria	1MU67@1224,2TRTZ@28211,COG0745@1,COG0745@2	NA|NA|NA	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MAG.T21.41_02988	330214.NIDE3135	1.2e-98	367.1	Bacteria			3.2.1.156	ko:K13735,ko:K15125,ko:K15531	ko05100,ko05133,map05100,map05133				ko00000,ko00001,ko00536,ko01000		GH8		Bacteria	COG0726@1,COG0726@2,COG2911@1,COG2911@2,COG2931@1,COG2931@2,COG3210@1,COG3210@2	NA|NA|NA	S	protein secretion
MAG.T21.41_02989	330214.NIDE1756	5.7e-139	500.4	Bacteria													Bacteria	COG1639@1,COG1639@2	NA|NA|NA	T	HDOD domain
MAG.T21.41_02990	330214.NIDE1758	7.7e-102	376.7	Nitrospirae													Bacteria	3J16V@40117,COG1814@1,COG1814@2	NA|NA|NA	S	VIT family
MAG.T21.41_02991	330214.NIDE1759	6e-268	929.9	Nitrospirae													Bacteria	3J0XZ@40117,COG0778@1,COG0778@2	NA|NA|NA	C	Nitroreductase
MAG.T21.41_02993	330214.NIDE1761	3.4e-36	157.9	Bacteria													Bacteria	2C8BN@1,32RKS@2	NA|NA|NA	S	Glycine-zipper domain
MAG.T21.41_02994	330214.NIDE1762	4.1e-56	224.2	Bacteria													Bacteria	COG5652@1,COG5652@2	NA|NA|NA		
MAG.T21.41_02995	330214.NIDE1763	2.7e-58	231.1	Bacteria	lpxC		3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_02996	330214.NIDE1765	0.0	1233.0	Bacteria				ko:K15726					ko00000,ko02000	2.A.6.1.2			Bacteria	COG3696@1,COG3696@2	NA|NA|NA	P	silver ion transport
MAG.T21.41_02997	330214.NIDE2564	2.5e-25	120.6	Bacteria													Bacteria	2EI4B@1,33BVP@2	NA|NA|NA		
MAG.T21.41_02998	330214.NIDE2565	8.3e-86	323.2	Nitrospirae	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	3J0V5@40117,COG0742@1,COG0742@2	NA|NA|NA	L	Conserved hypothetical protein 95
MAG.T21.41_02999	330214.NIDE2566	5.1e-84	317.0	Nitrospirae	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0MF@40117,COG0669@1,COG0669@2	NA|NA|NA	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MAG.T21.41_03000	330214.NIDE2567	5.2e-207	726.9	Nitrospirae	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230		R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007			iHN637.CLJU_RS06550	Bacteria	3J0EV@40117,COG0436@1,COG0436@2	NA|NA|NA	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03001	330214.NIDE2568	7.6e-35	153.3	Nitrospirae													Bacteria	3J0V8@40117,COG2331@1,COG2331@2	NA|NA|NA	S	Putative regulatory protein
MAG.T21.41_03003	330214.NIDE2572	7e-73	280.4	Nitrospirae	prmC		2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	3J0TD@40117,COG0009@1,COG0009@2	NA|NA|NA	J	Telomere recombination
MAG.T21.41_03004	330214.NIDE2573	3.6e-214	750.7	Nitrospirae	purD		6.3.2.6,6.3.4.13,6.3.5.3	ko:K01945,ko:K01952,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04463,R04591	RC00010,RC00064,RC00090,RC00162,RC00166,RC01160	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS05245,iYO844.BSU06530	Bacteria	3J0H5@40117,COG0151@1,COG0151@2	NA|NA|NA	F	Phosphoribosylglycinamide synthetase, C domain
MAG.T21.41_03005	330214.NIDE2574	9.2e-150	536.2	Nitrospirae	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147			iEcHS_1320.EcHS_A4240,iPC815.YPO3728	Bacteria	3J0CV@40117,COG0138@1,COG0138@2	NA|NA|NA	F	AICARFT/IMPCHase bienzyme
MAG.T21.41_03006	330214.NIDE2325	1.9e-95	355.5	Bacteria													Bacteria	COG5581@1,COG5581@2	NA|NA|NA	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed
MAG.T21.41_03007	330214.NIDE2324	7.8e-161	573.5	Nitrospirae													Bacteria	3J14V@40117,COG2206@1,COG2206@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03008	330214.NIDE2323	0.0	1441.4	Nitrospirae													Bacteria	3J0ZF@40117,COG0642@1,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_03009	330214.NIDE2322	4.5e-60	237.3	Nitrospirae	fliW			ko:K13626					ko00000,ko02035				Bacteria	3J0V2@40117,COG1699@1,COG1699@2	NA|NA|NA	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MAG.T21.41_03010	330214.NIDE2321	4.7e-38	163.3	Bacteria	csrA			ko:K03563,ko:K13626	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111				ko00000,ko00001,ko02035,ko03019				Bacteria	COG1551@1,COG1551@2	NA|NA|NA	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MAG.T21.41_03011	330214.NIDE2320	6.6e-138	496.9	Nitrospirae	flgL			ko:K02397	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0VI@40117,COG1344@1,COG1344@2	NA|NA|NA	N	Bacterial flagellin N-terminal helical region
MAG.T21.41_03012	330214.NIDE2319	6.3e-71	273.5	Nitrospirae	flgK			ko:K02396	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0M9@40117,COG1256@1,COG1256@2,COG4786@1,COG4786@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T21.41_03013	330214.NIDE1149	2.6e-23	115.5	Bacteria													Bacteria	2EIBB@1,33C2R@2	NA|NA|NA		
MAG.T21.41_03014	330214.NIDE1145	4e-92	344.7	Bacteria	merA												Bacteria	COG0398@1,COG0398@2	NA|NA|NA	M	Pfam SNARE associated Golgi protein
MAG.T21.41_03017	330214.NIDE1143	1.1e-115	422.5	Bacteria	yuiH												Bacteria	COG2041@1,COG2041@2	NA|NA|NA	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MAG.T21.41_03018	330214.NIDE1142	3.1e-169	601.3	Bacteria		GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802			R10938	RC03309	ko00000,ko01000				Bacteria	COG4948@1,COG4948@2	NA|NA|NA	M	carboxylic acid catabolic process
MAG.T21.41_03020	330214.NIDE1139	6.8e-36	156.0	Bacteria													Bacteria	COG1670@1,COG1670@2	NA|NA|NA	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAG.T21.41_03021	330214.NIDE1138	3.8e-133	481.1	Nitrospirae			1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100		R05066	RC00099	ko00000,ko00001,ko01000				Bacteria	3J0YI@40117,COG2084@1,COG2084@2	NA|NA|NA	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MAG.T21.41_03023	330214.NIDE1136	2.4e-74	285.0	Bacteria	hbpS			ko:K11477					ko00000				Bacteria	COG3193@1,COG3193@2	NA|NA|NA		
MAG.T21.41_03025	330214.NIDE1132	0.0	1113.6	Bacteria	glgX												Bacteria	COG3408@1,COG3408@2	NA|NA|NA	G	Glycogen debranching enzyme
MAG.T21.41_03026	330214.NIDE1131	0.0	1710.3	Bacteria				ko:K22110					ko00000,ko02000	1.B.35.1,1.B.35.2			Bacteria	COG1452@1,COG1452@2	NA|NA|NA	M	lipopolysaccharide transport
MAG.T21.41_03028	330214.NIDE1129	9.5e-165	586.3	Bacteria													Bacteria	COG4677@1,COG4677@2	NA|NA|NA	G	pectinesterase activity
MAG.T21.41_03029	330214.NIDE1128	7.6e-82	310.1	Nitrospirae	coaE		2.7.1.24,6.3.4.4	ko:K00859,ko:K01939	ko00230,ko00250,ko00770,ko01100,map00230,map00250,map00770,map01100	M00049,M00120	R00130,R01135	RC00002,RC00078,RC00458,RC00459	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0RK@40117,COG0237@1,COG0237@2	NA|NA|NA	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MAG.T21.41_03030	330214.NIDE1127	1.6e-147	528.9	Nitrospirae	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K03671,ko:K22345	ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418		R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110			iNJ661.Rv3913,iPC815.YPO1374	Bacteria	3J0M0@40117,COG0492@1,COG0492@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase
MAG.T21.41_03031	717231.Flexsi_1740	1.4e-25	122.5	Bacteria													Bacteria	2DNS7@1,32YWC@2	NA|NA|NA	S	S23 ribosomal protein
MAG.T21.41_03032	330214.NIDE1125	1.1e-196	692.6	Bacteria	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07461		ko00000,ko00001,ko01000,ko03016			iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	Bacteria	COG0301@1,COG0301@2	NA|NA|NA	H	tRNA thio-modification
MAG.T21.41_03033	330214.NIDE1124	1e-73	283.1	Bacteria	sppD		2.3.1.235	ko:K05554,ko:K14670,ko:K15886	ko01056,ko01057,ko01130,map01056,map01057,map01130	M00778,M00783	R06701,R09265,R09269,R10960	RC00392,RC02496,RC02546	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008				Bacteria	COG2867@1,COG2867@2	NA|NA|NA	I	negative regulation of translational initiation
MAG.T21.41_03034	1173026.Glo7428_3883	1.1e-51	210.3	Bacteria													Bacteria	COG0784@1,COG0784@2,COG5002@1,COG5002@2	NA|NA|NA	T	Response regulator, receiver
MAG.T21.41_03036	330214.NIDE1121	4e-144	517.7	Nitrospirae	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979					ko00000,ko01000,ko03016				Bacteria	3J19A@40117,COG1600@1,COG1600@2	NA|NA|NA	C	Domain of unknown function (DUF1730)
MAG.T21.41_03040	330214.NIDE0987	1.2e-104	386.0	Nitrospirae	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01496,ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1606,iSB619.SA_RS14110,iYO844.BSU34860	Bacteria	3J0T7@40117,COG0139@1,COG0139@2,COG0140@1,COG0140@2	NA|NA|NA	E	Phosphoribosyl-AMP cyclohydrolase
MAG.T21.41_03041	330214.NIDE0986	6e-127	460.3	Nitrospirae	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763		ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0GV@40117,COG0107@1,COG0107@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MAG.T21.41_03042	330214.NIDE0985	2.9e-112	411.4	Nitrospirae	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0KA@40117,COG0106@1,COG0106@2	NA|NA|NA	E	Histidine biosynthesis protein
MAG.T21.41_03043	667014.Thein_1211	7.8e-12	77.8	Thermodesulfobacteria													Bacteria	2E6CS@1,2GH18@200940,3310E@2	NA|NA|NA		
MAG.T21.41_03044	330214.NIDE0983	2e-98	365.2	Nitrospirae	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0K7@40117,COG0118@1,COG0118@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MAG.T21.41_03045	330214.NIDE0982	6.7e-102	376.7	Nitrospirae	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19	ko:K00013,ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457	RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007			iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570	Bacteria	3J0JI@40117,COG0131@1,COG0131@2	NA|NA|NA	E	Imidazoleglycerol-phosphate dehydratase
MAG.T21.41_03046	330214.NIDE0981	2.5e-223	781.2	Nitrospirae	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000			iYO844.BSU34910	Bacteria	3J0C6@40117,COG0141@1,COG0141@2	NA|NA|NA	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MAG.T21.41_03047	330214.NIDE0980	4.2e-102	377.5	Nitrospirae	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0T5@40117,COG0040@1,COG0040@2	NA|NA|NA	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MAG.T21.41_03048	330214.NIDE0979	3.3e-204	717.6	Nitrospirae	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100		R00660	RC00350	ko00000,ko00001,ko01000,ko01011				Bacteria	3J0EE@40117,COG0766@1,COG0766@2	NA|NA|NA	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MAG.T21.41_03049	330214.NIDE0978	1.4e-98	366.3	Nitrospirae	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493			R10806	RC00003,RC03279	ko00000,ko01000,ko03012				Bacteria	3J0N5@40117,COG2890@1,COG2890@2	NA|NA|NA	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MAG.T21.41_03050	330214.NIDE0977	2.1e-183	648.3	Nitrospirae	prfA			ko:K02835					ko00000,ko03012				Bacteria	3J0F6@40117,COG0216@1,COG0216@2	NA|NA|NA	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MAG.T21.41_03051	330214.NIDE0976	1.9e-32	144.4	Nitrospirae	rpmE	GO:0008150,GO:0040007		ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0S4@40117,COG0254@1,COG0254@2	NA|NA|NA	J	Binds the 23S rRNA
MAG.T21.41_03052	330214.NIDE0975	5.7e-236	823.2	Nitrospirae	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021				Bacteria	3J0BK@40117,COG1158@1,COG1158@2	NA|NA|NA	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MAG.T21.41_03053	330214.NIDE0974	3.5e-63	247.7	Bacteria													Bacteria	COG4911@1,COG4911@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2203)
MAG.T21.41_03054	1384056.N787_00520	1e-13	82.8	Xanthomonadales	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05527,ko:K09780					ko00000,ko03000				Bacteria	1MZ9Z@1224,1S8UC@1236,1X7QC@135614,COG2350@1,COG2350@2	NA|NA|NA	S	BolA family transcriptional regulator
MAG.T21.41_03055	330214.NIDE0972	1.8e-118	431.8	Nitrospirae				ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	3J0YH@40117,COG0226@1,COG0226@2	NA|NA|NA	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03056	330214.NIDE0971	5.4e-236	823.2	Nitrospirae	porA		1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0WN@40117,COG0674@1,COG0674@2	NA|NA|NA	C	Pyruvate:ferredoxin oxidoreductase core domain II
MAG.T21.41_03057	330214.NIDE0970	1.5e-166	592.0	Nitrospirae	porB		1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0Z2@40117,COG1013@1,COG1013@2	NA|NA|NA	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
MAG.T21.41_03058	330214.NIDE0969	3.6e-123	447.6	Nitrospirae			1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0Y6@40117,COG1014@1,COG1014@2	NA|NA|NA	C	Pyruvate ferredoxin/flavodoxin oxidoreductase
MAG.T21.41_03059	330214.NIDE0968	1.3e-36	158.7	Nitrospirae	porE		1.2.7.1	ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J1DG@40117,COG1144@1,COG1144@2	NA|NA|NA	C	Oxidoreductase
MAG.T21.41_03064	1304883.KI912532_gene2937	8.7e-100	370.5	Proteobacteria													Bacteria	1RAC8@1224,2DBHN@1,2Z9BF@2	NA|NA|NA		
MAG.T21.41_03066	1037409.BJ6T_25070	2.9e-42	179.9	Alphaproteobacteria													Bacteria	1RCJY@1224,28PQC@1,2U8GR@28211,2ZCCE@2	NA|NA|NA		
MAG.T21.41_03069	330214.NIDE2200	4.1e-97	360.9	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_03070	330214.NIDE2199	2.3e-258	897.9	Nitrospirae													Bacteria	3J14V@40117,COG2206@1,COG2206@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03072	330214.NIDE2197	8.2e-62	243.4	Nitrospirae	ompH			ko:K06142					ko00000				Bacteria	3J1AH@40117,COG2825@1,COG2825@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03073	330214.NIDE2196	1.9e-163	582.0	Bacteria													Bacteria	COG2006@1,COG2006@2	NA|NA|NA	U	4fe-4S ferredoxin, iron-sulfur binding domain protein
MAG.T21.41_03074	330214.NIDE2195	1.7e-42	178.7	Bacteria													Bacteria	COG0607@1,COG0607@2	NA|NA|NA	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAG.T21.41_03075	330214.NIDE2194	5.6e-157	560.5	Nitrospirae	splB												Bacteria	3J0QV@40117,COG1533@1,COG1533@2	NA|NA|NA	L	Elongator protein 3, MiaB family, Radical SAM
MAG.T21.41_03076	330214.NIDE2193	1.2e-217	762.3	Nitrospirae	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF987.Gmet_3528,iSDY_1059.SDY_2368	Bacteria	3J0EP@40117,COG0172@1,COG0172@2	NA|NA|NA	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MAG.T21.41_03078	1301098.PKB_4316	2.1e-47	195.7	Gammaproteobacteria													Bacteria	1MXVZ@1224,1S723@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T21.41_03081	330214.NIDE3373	1.8e-154	552.0	Bacteria				ko:K20333	ko02024,map02024				ko00000,ko00001				Bacteria	COG1262@1,COG1262@2	NA|NA|NA	T	PFAM Formylglycine-generating sulfatase enzyme
MAG.T21.41_03082	330214.NIDE3374	6.5e-138	497.3	Bacteria													Bacteria	28I4Y@1,2Z88D@2	NA|NA|NA		
MAG.T21.41_03084	330214.NIDE3376	7.5e-63	246.5	Bacteria													Bacteria	2ETMV@1,33M5M@2	NA|NA|NA	S	Domain of unknown function (DUF5069)
MAG.T21.41_03085	330214.NIDE3183	1.7e-72	278.9	Bacteria	slyD		5.2.1.8	ko:K03775					ko00000,ko01000,ko03110				Bacteria	COG1047@1,COG1047@2	NA|NA|NA	O	modulation by symbiont of host adenylate cyclase-mediated signal transduction
MAG.T21.41_03086	330214.NIDE3184	7.2e-229	799.7	Bacteria	rhlE		3.6.4.13	ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	COG0513@1,COG0513@2	NA|NA|NA	L	helicase activity
MAG.T21.41_03087	330214.NIDE3327	1.4e-36	158.7	Bacteria	rbpA												Bacteria	COG0724@1,COG0724@2	NA|NA|NA	K	RNA recognition motif
MAG.T21.41_03088	247490.KSU1_B0516	6.2e-09	68.2	Planctomycetes			2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	2IZTQ@203682,COG3848@1,COG3848@2	NA|NA|NA	T	Pyruvate phosphate dikinase
MAG.T21.41_03091	330214.NIDE3190	7.2e-188	663.7	Bacteria													Bacteria	COG2234@1,COG2234@2	NA|NA|NA	DZ	aminopeptidase activity
MAG.T21.41_03092	330214.NIDE3191	0.0	1395.2	Nitrospirae	MA20_17380												Bacteria	3J0Z8@40117,COG3408@1,COG3408@2	NA|NA|NA	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
MAG.T21.41_03093	330214.NIDE3192	1.2e-201	709.1	Bacteria													Bacteria	COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T21.41_03094	330214.NIDE3193	2e-74	286.2	Bacteria	tolA		2.7.13.3	ko:K03407,ko:K03646,ko:K04065,ko:K06596,ko:K07277,ko:K12065,ko:K13593	ko02020,ko02025,ko02030,ko04112,map02020,map02025,map02030,map04112	M00506,M00507			ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035,ko02044,ko03029	1.B.33,2.C.1.2,3.A.7.11.1			Bacteria	COG2823@1,COG2823@2,COG3170@1,COG3170@2	NA|NA|NA	S	hyperosmotic response
MAG.T21.41_03095	330214.NIDE3194	5.2e-213	746.9	Nitrospirae													Bacteria	3J0RT@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03096	330214.NIDE3195	1.2e-194	685.6	Nitrospirae	MA20_17390			ko:K00713,ko:K06338					ko00000,ko01000,ko01003,ko01005				Bacteria	3J120@40117,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyltransferase Family 4
MAG.T21.41_03097	118166.JH976537_gene2419	1.2e-80	306.6	Cyanobacteria													Bacteria	1G5MR@1117,28NY3@1,2ZBVC@2	NA|NA|NA		
MAG.T21.41_03098	330214.NIDE1198	4.4e-85	321.6	Bacteria													Bacteria	COG1413@1,COG1413@2	NA|NA|NA	C	deoxyhypusine monooxygenase activity
MAG.T21.41_03100	1499967.BAYZ01000021_gene207	2e-07	63.5	Bacteria													Bacteria	2DSRS@1,33H75@2	NA|NA|NA	S	Curli production assembly/transport component CsgG
MAG.T21.41_03101	330214.NIDE1195	2.7e-127	461.5	Nitrospirae	thiD		2.5.1.3,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00941,ko:K03147,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2909	Bacteria	3J0RM@40117,COG0351@1,COG0351@2	NA|NA|NA	H	Phosphomethylpyrimidine kinase
MAG.T21.41_03103	330214.NIDE1193	4.3e-112	411.0	Bacteria				ko:K06889,ko:K07397					ko00000				Bacteria	COG1073@1,COG1073@2	NA|NA|NA	S	thiolester hydrolase activity
MAG.T21.41_03104	330214.NIDE1191	2.1e-186	659.1	Bacteria				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	COG4733@1,COG4733@2	NA|NA|NA	S	cellulase activity
MAG.T21.41_03105	330214.NIDE1190	1.1e-111	409.8	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_03106	330214.NIDE1189	1.3e-106	392.5	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_03107	330214.NIDE1188	1.6e-61	242.3	Bacteria													Bacteria	COG2258@1,COG2258@2	NA|NA|NA	C	MOSC domain
MAG.T21.41_03108	330214.NIDE1187	2.6e-32	144.4	Nitrospirae	prmA			ko:K02687					ko00000,ko01000,ko03009				Bacteria	3J1B7@40117,COG2264@1,COG2264@2	NA|NA|NA	J	Ribosomal protein L11 methyltransferase (PrmA)
MAG.T21.41_03109	371731.Rsw2DRAFT_2077	8.8e-87	326.6	Alphaproteobacteria				ko:K03205	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1MV1G@1224,2TR6N@28211,COG3505@1,COG3505@2	NA|NA|NA	U	Type IV secretory pathway VirD4
MAG.T21.41_03111	69279.BG36_04845	4.9e-32	144.4	Alphaproteobacteria			3.6.4.12	ko:K03655,ko:K07506	ko03440,map03440				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	1QVE1@1224,2TWD0@28211,COG1846@1,COG1846@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_03113	335543.Sfum_3855	4e-142	511.5	Deltaproteobacteria													Bacteria	1MXVM@1224,2CE5F@1,2WJY4@28221,2Z7YQ@2,42Q53@68525	NA|NA|NA		
MAG.T21.41_03114	69279.BG36_08285	4.1e-97	361.7	Alphaproteobacteria													Bacteria	1RF49@1224,2U7J6@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_03115	69279.BG36_08290	8.6e-114	417.5	Alphaproteobacteria													Bacteria	1MYSV@1224,2BY0Y@1,2UNSW@28211,32R2C@2	NA|NA|NA		
MAG.T21.41_03116	411684.HPDFL43_01725	1.1e-21	109.0	Phyllobacteriaceae	wbpP		5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	1QUEV@1224,2TW46@28211,43R32@69277,COG0451@1,COG0451@2	NA|NA|NA	M	NmrA-like family
MAG.T21.41_03117	324057.Pjdr2_3164	2.2e-240	839.7	Paenibacillaceae													Bacteria	1VRZ7@1239,26SSG@186822,4I6FJ@91061,COG3391@1,COG3391@2	NA|NA|NA	S	PFAM NHL repeat containing protein
MAG.T21.41_03119	371731.Rsw2DRAFT_2034	1e-227	795.8	Alphaproteobacteria	mntH			ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3			Bacteria	1MW6X@1224,2TUTC@28211,COG1914@1,COG1914@2	NA|NA|NA	P	H( )-stimulated, divalent metal cation uptake system
MAG.T21.41_03120	272943.RSP_1199	3.1e-67	261.5	Rhodobacter													Bacteria	1FBN9@1060,1MVYT@1224,2TUXV@28211,COG1376@1,COG1376@2	NA|NA|NA	S	PFAM ErfK YbiS YcfS YnhG family protein
MAG.T21.41_03121	330214.NIDE1807	2.2e-48	198.0	Nitrospirae	mdlB			ko:K06147,ko:K11085	ko02010,map02010				ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	3J0X8@40117,COG1132@1,COG1132@2	NA|NA|NA	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03125	330214.NIDE1815	1.2e-88	332.4	Nitrospirae	mec		3.13.1.6	ko:K21140	ko04122,map04122		R11524	RC00064,RC00090	ko00000,ko00001,ko01000				Bacteria	3J0U8@40117,COG1310@1,COG1310@2	NA|NA|NA	S	JAB/MPN domain
MAG.T21.41_03126	330214.NIDE1816	1.9e-144	518.5	Nitrospirae	moeB		2.7.7.80	ko:K21029	ko04122,map04122		R07459	RC00043	ko00000,ko00001,ko01000				Bacteria	3J0X5@40117,COG0476@1,COG0476@2	NA|NA|NA	H	ThiF family
MAG.T21.41_03127	330214.NIDE1817	5.1e-37	159.8	Nitrospirae				ko:K02071	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24			Bacteria	3J0VT@40117,COG1135@1,COG1135@2	NA|NA|NA	P	NIL
MAG.T21.41_03128	330214.NIDE1818	5.4e-43	179.9	Nitrospirae			2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122		R07459,R07461	RC00043	ko00000,ko00001,ko01000				Bacteria	3J0T2@40117,COG1977@1,COG1977@2	NA|NA|NA	H	ThiS family
MAG.T21.41_03129	330214.NIDE1819	3.3e-231	807.4	Nitrospirae	thrC1		4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0FZ@40117,COG0498@1,COG0498@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T21.41_03130	330214.NIDE1820	2.1e-146	525.0	Nitrospirae	moeB		2.7.7.80	ko:K21029	ko04122,map04122		R07459	RC00043	ko00000,ko00001,ko01000			iIT341.HP0814	Bacteria	3J0WD@40117,COG0476@1,COG0476@2	NA|NA|NA	H	ThiF family
MAG.T21.41_03131	330214.NIDE1821	9.2e-167	592.8	Nitrospirae	cysK-1		2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0HD@40117,COG0031@1,COG0031@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T21.41_03132	330214.NIDE1822	1.4e-27	128.3	Bacteria	thiS			ko:K03154	ko04122,map04122				ko00000,ko00001				Bacteria	COG2104@1,COG2104@2	NA|NA|NA	H	thiamine diphosphate biosynthetic process
MAG.T21.41_03134	330214.NIDE1825	2e-81	308.5	Nitrospirae	nuc		3.1.4.4	ko:K06131,ko:K17717	ko00564,ko00565,ko01100,ko01110,map00564,map00565,map01100,map01110		R01310,R02051,R07385,R07390	RC00017,RC00425	ko00000,ko00001,ko01000				Bacteria	3J1DV@40117,COG1502@1,COG1502@2	NA|NA|NA	I	PLD-like domain
MAG.T21.41_03135	330214.NIDE1826	1.3e-211	742.3	Nitrospirae	MA20_30655		1.14.13.232	ko:K14253	ko00253,ko01057,ko01130,map00253,map01057,map01130	M00780,M00823	R05463	RC00236	ko00000,ko00001,ko00002,ko01000				Bacteria	3J16C@40117,COG0654@1,COG0654@2	NA|NA|NA	C	FAD binding domain
MAG.T21.41_03136	330214.NIDE1827	1.4e-120	439.1	Bacteria	ant1		2.7.7.47	ko:K00984,ko:K19279					ko00000,ko01000,ko01504				Bacteria	COG1708@1,COG1708@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T21.41_03137	330214.NIDE1828	3.6e-110	404.4	Bacteria				ko:K06872					ko00000				Bacteria	COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
MAG.T21.41_03139	330214.NIDE1836	4.5e-43	180.6	Bacteria			5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000				Bacteria	COG3631@1,COG3631@2	NA|NA|NA	S	light absorption
MAG.T21.41_03140	330214.NIDE1844	1.9e-58	232.3	Bacteria				ko:K11932					ko00000				Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_03141	330214.NIDE1847	2.8e-57	228.0	Nitrospirae													Bacteria	2DQ7E@1,3353C@2,3J1EM@40117	NA|NA|NA	S	Domain of unknown function (DUF5069)
MAG.T21.41_03142	330214.NIDE1848	2.1e-112	411.8	Bacteria													Bacteria	COG3055@1,COG3055@2	NA|NA|NA	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MAG.T21.41_03144	330214.NIDE1850	3.4e-43	180.6	Bacteria	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087		ko:K06891					ko00000				Bacteria	COG2127@1,COG2127@2	NA|NA|NA	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MAG.T21.41_03147	330214.NIDE1853	7.2e-97	360.5	Nitrospirae													Bacteria	3J10W@40117,COG0635@1,COG0635@2	NA|NA|NA	H	Elongator protein 3, MiaB family, Radical SAM
MAG.T21.41_03148	330214.NIDE0782	6.5e-102	377.1	Nitrospirae	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02897	ko03010,map03010	M00178			ko00000,ko00001,ko00002,ko03011				Bacteria	3J0NK@40117,COG1825@1,COG1825@2	NA|NA|NA	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MAG.T21.41_03149	330214.NIDE0781	9.6e-164	582.8	Nitrospirae	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2848	Bacteria	3J0D0@40117,COG0462@1,COG0462@2	NA|NA|NA	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MAG.T21.41_03150	330214.NIDE0780	1.7e-108	399.1	Nitrospirae	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29		iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	Bacteria	3J0N1@40117,COG1947@1,COG1947@2	NA|NA|NA	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MAG.T21.41_03151	330214.NIDE0779	2.1e-244	851.3	Bacteria	pilR			ko:K02667	ko02020,map02020	M00501			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_03152	330214.NIDE0778	4.1e-282	976.9	Bacteria	pilS		2.7.13.3	ko:K02668	ko02020,map02020	M00501			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	COG5000@1,COG5000@2	NA|NA|NA	T	phosphorelay sensor kinase activity
MAG.T21.41_03153	330214.NIDE0777	8.8e-210	736.1	Nitrospirae	pilC			ko:K02653					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	3J0HZ@40117,COG1459@1,COG1459@2	NA|NA|NA	U	Type II secretion system (T2SS), protein F
MAG.T21.41_03155	330214.NIDE0775	4.3e-84	317.4	Nitrospirae	pgsA-2		2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	3J183@40117,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T21.41_03157	330214.NIDE0773	4.5e-152	544.3	Nitrospirae			3.4.16.4	ko:K21469	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	3J131@40117,COG1680@1,COG1680@2	NA|NA|NA	V	Beta-lactamase
MAG.T21.41_03158	330214.NIDE0772	3.7e-61	241.1	Nitrospirae	divIVA			ko:K04074					ko00000,ko03036				Bacteria	3J19M@40117,COG3599@1,COG3599@2	NA|NA|NA	D	DivIVA protein
MAG.T21.41_03159	330214.NIDE0771	8.2e-45	186.0	Nitrospirae	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02221					ko00000,ko02044				Bacteria	3J0U5@40117,COG0762@1,COG0762@2	NA|NA|NA	S	YGGT family
MAG.T21.41_03160	330214.NIDE0770	1.7e-113	415.6	Nitrospirae	proC	GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0899,iIT341.HP1158,iSBO_1134.SBO_0282,ic_1306.c0493	Bacteria	3J0N8@40117,COG0345@1,COG0345@2	NA|NA|NA	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAG.T21.41_03161	330214.NIDE0769	2.4e-98	365.2	Nitrospirae	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363		ko:K06997					ko00000				Bacteria	3J0RJ@40117,COG0325@1,COG0325@2	NA|NA|NA	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MAG.T21.41_03162	330214.NIDE0768	4.1e-101	374.4	Nitrospirae	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944		ko:K05810					ko00000,ko01000				Bacteria	3J0TC@40117,COG1496@1,COG1496@2	NA|NA|NA	S	Belongs to the multicopper oxidase YfiH RL5 family
MAG.T21.41_03163	330214.NIDE0767	2.9e-213	747.7	Nitrospirae	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03531	ko04112,map04112				ko00000,ko00001,ko02048,ko03036,ko04812				Bacteria	3J0D4@40117,COG0206@1,COG0206@2	NA|NA|NA	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MAG.T21.41_03164	330214.NIDE0766	5.6e-228	796.6	Nitrospirae	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K03590	ko04112,map04112				ko00000,ko00001,ko03036,ko04812				Bacteria	3J0Q3@40117,COG0849@1,COG0849@2	NA|NA|NA	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MAG.T21.41_03165	330214.NIDE0765	1.6e-141	508.8	Bacteria	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036				Bacteria	COG1589@1,COG1589@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MAG.T21.41_03166	330214.NIDE0764	6.4e-152	543.5	Nitrospirae	ddl		6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	3J0JM@40117,COG1181@1,COG1181@2	NA|NA|NA	F	Cell wall formation
MAG.T21.41_03167	330214.NIDE0763	5.9e-150	537.0	Nitrospirae	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502		R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011			iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230	Bacteria	3J0Q1@40117,COG0812@1,COG0812@2	NA|NA|NA	M	Cell wall formation
MAG.T21.41_03168	330214.NIDE0762	6.1e-253	879.8	Nitrospirae	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100		R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iECP_1309.ECP_0093,iJN678.murC	Bacteria	3J0D5@40117,COG0773@1,COG0773@2	NA|NA|NA	M	Belongs to the MurCDEF family
MAG.T21.41_03169	330214.NIDE0761	1.1e-169	602.8	Nitrospirae	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011		GT28	iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Bacteria	3J0JS@40117,COG0707@1,COG0707@2	NA|NA|NA	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAG.T21.41_03170	330214.NIDE0760	1.1e-89	336.3	Nitrospirae	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28		Bacteria	3J0M8@40117,COG0772@1,COG0772@2	NA|NA|NA	D	Cell cycle protein
MAG.T21.41_03171	1210884.HG799464_gene10869	5.8e-119	434.5	Planctomycetes				ko:K07493					ko00000				Bacteria	2J0T4@203682,COG3328@1,COG3328@2	NA|NA|NA	L	COG3328 Transposase and inactivated derivatives
MAG.T21.41_03173	330214.NIDE2151	1.3e-66	259.6	Bacteria													Bacteria	COG1020@1,COG1020@2	NA|NA|NA	Q	D-alanine [D-alanyl carrier protein] ligase activity
MAG.T21.41_03174	330214.NIDE2150	0.0	2612.4	Bacteria													Bacteria	COG0318@1,COG0318@2,COG1020@1,COG1020@2,COG4122@1,COG4122@2	NA|NA|NA	E	O-methyltransferase activity
MAG.T21.41_03175	330214.NIDE2208	1.3e-203	715.7	Bacteria				ko:K03301					ko00000	2.A.12			Bacteria	COG3202@1,COG3202@2	NA|NA|NA	C	ATP:ADP antiporter activity
MAG.T21.41_03176	330214.NIDE2207	1.8e-155	555.4	Bacteria	ltaA		4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230		R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000				Bacteria	COG2008@1,COG2008@2	NA|NA|NA	E	L-allo-threonine aldolase activity
MAG.T21.41_03178	330214.NIDE2205	1.8e-131	475.3	Bacteria				ko:K17882					ko00000,ko01000,ko01504				Bacteria	COG1708@1,COG1708@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T21.41_03179	330214.NIDE2204	2.6e-158	564.7	Bacteria	gnd		1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1023@1,COG1023@2	NA|NA|NA	G	D-gluconate metabolic process
MAG.T21.41_03180	330214.NIDE2203	6e-272	943.0	Nitrospirae	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0XD@40117,COG0364@1,COG0364@2	NA|NA|NA	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAG.T21.41_03181	330214.NIDE2202	2e-16	90.9	Bacteria			1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110				Bacteria	COG3118@1,COG3118@2	NA|NA|NA	O	belongs to the thioredoxin family
MAG.T21.41_03183	330214.NIDE1441	2.9e-190	671.0	Bacteria	nia		1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120		R00533	RC00168	ko00000,ko00001,ko01000				Bacteria	COG2041@1,COG2041@2	NA|NA|NA	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MAG.T21.41_03185	768671.ThimaDRAFT_1795	8.4e-34	150.2	Chromatiales	tadA		3.5.4.3,3.5.4.33	ko:K01487,ko:K11991	ko00230,ko01100,map00230,map01100		R01676,R10223	RC00204,RC00477	ko00000,ko00001,ko01000,ko03016				Bacteria	1RHM4@1224,1S4RE@1236,1WY1Y@135613,COG0590@1,COG0590@2	NA|NA|NA	FJ	CMP dCMP deaminase, zinc-binding
MAG.T21.41_03187	330214.NIDE1434	2.3e-78	298.5	Nitrospirae	rluE	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181					ko00000,ko01000,ko03009				Bacteria	3J0RN@40117,COG1187@1,COG1187@2	NA|NA|NA	J	Belongs to the pseudouridine synthase RsuA family
MAG.T21.41_03189	330214.NIDE1431	7.5e-139	500.0	Bacteria	ypfJ	GO:0005575,GO:0005576		ko:K07054					ko00000				Bacteria	COG2321@1,COG2321@2	NA|NA|NA	S	Putative neutral zinc metallopeptidase
MAG.T21.41_03190	330214.NIDE1430	2.6e-67	261.9	Nitrospirae	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802		ko:K07285					ko00000				Bacteria	3J1BB@40117,COG3065@1,COG3065@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03191	330214.NIDE1429	4e-163	580.9	Bacteria			3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T21.41_03192	330214.NIDE1428	2.7e-114	419.1	Bacteria	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3			Bacteria	COG1119@1,COG1119@2	NA|NA|NA	P	ATPase activity
MAG.T21.41_03193	330214.NIDE1426	4.1e-188	664.1	Nitrospirae	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iIT341.HP0663,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Bacteria	3J0KQ@40117,COG0082@1,COG0082@2	NA|NA|NA	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MAG.T21.41_03194	330214.NIDE1425	6.7e-232	809.7	Nitrospirae	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iJN678.aspS,iSFV_1184.SFV_1868	Bacteria	3J0FR@40117,COG0173@1,COG0173@2	NA|NA|NA	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAG.T21.41_03198	330214.NIDE4374	1.5e-121	442.6	Bacteria	rmlD		1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1091@1,COG1091@2	NA|NA|NA	M	dTDP-4-dehydrorhamnose reductase activity
MAG.T21.41_03199	330214.NIDE4375	8e-88	330.1	Bacteria			1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100		R05692	RC01014	ko00000,ko00001,ko01000				Bacteria	COG0702@1,COG0702@2	NA|NA|NA	GM	epimerase
MAG.T21.41_03200	330214.NIDE4376	1.5e-159	569.3	Bacteria				ko:K07001					ko00000				Bacteria	COG1752@1,COG1752@2	NA|NA|NA	M	Esterase of the alpha-beta hydrolase superfamily
MAG.T21.41_03201	330214.NIDE4377	2.6e-37	161.0	Nitrospirae	yjjK	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	3.6.3.25	ko:K06020					ko00000,ko01000				Bacteria	3J0WR@40117,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T21.41_03203	330214.NIDE2987	5.2e-183	647.1	Bacteria	wcnD												Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_03204	330214.NIDE2986	1.9e-253	881.3	Bacteria	wcaJ			ko:K03606,ko:K20997	ko02025,ko05111,map02025,map05111				ko00000,ko00001				Bacteria	COG1086@1,COG1086@2,COG2148@1,COG2148@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_03205	330214.NIDE2985	1.1e-69	269.6	Nitrospirae	kdsC	GO:0003674,GO:0003824,GO:0008781,GO:0016740,GO:0016772,GO:0016779,GO:0070567	2.5.1.55,2.7.7.43,2.7.7.92,3.1.3.103,3.1.3.45	ko:K01627,ko:K03270,ko:K21055,ko:K21749	ko00520,ko00540,ko01100,map00520,map00540,map01100	M00063	R01117,R03254,R03350,R04215,R11440	RC00017,RC00152,RC00435	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J1EJ@40117,COG1778@1,COG1778@2	NA|NA|NA	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MAG.T21.41_03206	330214.NIDE2984	6.5e-252	876.3	Nitrospirae	manC		2.7.7.13,5.3.1.8,5.4.2.8	ko:K00971,ko:K01840,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01818,R01819	RC00002,RC00376,RC00408	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS00940	Bacteria	3J0FF@40117,COG0662@1,COG0662@2,COG0836@1,COG0836@2	NA|NA|NA	GM	Belongs to the mannose-6-phosphate isomerase type 2 family
MAG.T21.41_03207	330214.NIDE2983	1.9e-245	854.7	Nitrospirae	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0AF@40117,COG1109@1,COG1109@2	NA|NA|NA	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
MAG.T21.41_03208	330214.NIDE2982	3.4e-112	411.4	Nitrospirae													Bacteria	3J1DA@40117,COG3170@1,COG3170@2	NA|NA|NA	NU	Protein of unknown function (DUF3108)
MAG.T21.41_03209	330214.NIDE2981	1.7e-150	538.9	Nitrospirae	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147			iUTI89_1310.UTI89_C4836,ic_1306.c5329	Bacteria	3J12X@40117,COG0158@1,COG0158@2	NA|NA|NA	G	Fructose-1-6-bisphosphatase, N-terminal domain
MAG.T21.41_03210	330214.NIDE2980	2.6e-161	574.7	Nitrospirae	fbaB		4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1DE@40117,COG1830@1,COG1830@2	NA|NA|NA	G	DeoC/LacD family aldolase
MAG.T21.41_03211	330214.NIDE2979	9.4e-265	919.1	Nitrospirae	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0X9@40117,COG0265@1,COG0265@2	NA|NA|NA	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03212	330214.NIDE2978	3.7e-169	600.9	Nitrospirae	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944											Bacteria	3J0G5@40117,COG4956@1,COG4956@2	NA|NA|NA	S	Large family of predicted nucleotide-binding domains
MAG.T21.41_03213	330214.NIDE2977	1.2e-110	406.0	Nitrospirae	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12	ko:K00991,ko:K12506,ko:K21030,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633,R05637	RC00002,RC00089,RC01440	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS20335	Bacteria	3J18C@40117,COG1211@1,COG1211@2	NA|NA|NA	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
MAG.T21.41_03214	330214.NIDE2976	4.1e-78	297.4	Nitrospirae	ispF	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006720,GO:0006721,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0030145,GO:0040007,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051483,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.228,2.7.7.60,4.6.1.12	ko:K00554,ko:K00991,ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05633,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016			iNJ661.Rv3581c,iPC815.YPO3360	Bacteria	3J0N6@40117,COG0245@1,COG0245@2	NA|NA|NA	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MAG.T21.41_03215	330214.NIDE2975	2.4e-105	388.3	Nitrospirae	cysE	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS02865,iYO844.BSU00930	Bacteria	3J11G@40117,COG1045@1,COG1045@2	NA|NA|NA	E	Serine acetyltransferase, N-terminal
MAG.T21.41_03216	330214.NIDE2973	3.5e-36	157.5	Nitrospirae	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173					ko00000,ko01000,ko03016				Bacteria	3J0PM@40117,COG0101@1,COG0101@2	NA|NA|NA	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MAG.T21.41_03218	330214.NIDE3948	1.3e-93	350.1	Bacteria													Bacteria	2CB8G@1,2Z88H@2	NA|NA|NA	S	Putative beta-barrel porin-2, OmpL-like. bbp2
MAG.T21.41_03219	105559.Nwat_1956	4.6e-16	91.3	Chromatiales													Bacteria	1N3R4@1224,1SD9Q@1236,1X22P@135613,2DDG6@1,32U1E@2	NA|NA|NA	S	Cytochrome C'
MAG.T21.41_03220	1121935.AQXX01000089_gene4659	6.4e-39	166.4	Oceanospirillales	ytcD												Bacteria	1RH3S@1224,1S6IG@1236,1XJY6@135619,COG1733@1,COG1733@2	NA|NA|NA	K	HxlR-like helix-turn-helix
MAG.T21.41_03221	1121935.AQXX01000089_gene4660	2.9e-94	351.7	Oceanospirillales													Bacteria	1MUWP@1224,1RQ8D@1236,1XHWI@135619,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T21.41_03222	330214.NIDE2130	9.7e-71	273.1	Bacteria													Bacteria	COG2128@1,COG2128@2	NA|NA|NA	S	hydroperoxide reductase activity
MAG.T21.41_03223	857087.Metme_3572	7.3e-22	109.4	Gammaproteobacteria			5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000				Bacteria	1NBW3@1224,1SECR@1236,COG1942@1,COG1942@2	NA|NA|NA	S	4-oxalocrotonate tautomerase
MAG.T21.41_03224	330214.NIDE2124	1.8e-70	271.9	Bacteria				ko:K07182					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_03227	869210.Marky_0299	2.2e-28	131.7	Deinococcus-Thermus													Bacteria	1WKRN@1297,COG3370@1,COG3370@2	NA|NA|NA	S	PFAM DsrE DsrF-like family
MAG.T21.41_03230	663610.JQKO01000004_gene2870	1.5e-15	89.0	Proteobacteria			4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220		R03470	RC00938	ko00000,ko00001,ko01000				Bacteria	1P0E1@1224,COG0599@1,COG0599@2	NA|NA|NA	S	Carboxymuconolactone decarboxylase family
MAG.T21.41_03231	452637.Oter_1218	6.5e-22	110.5	Verrucomicrobia	zntR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K13638					ko00000,ko03000				Bacteria	46W3K@74201,COG0789@1,COG0789@2	NA|NA|NA	K	Transcription regulator MerR DNA binding
MAG.T21.41_03232	330214.NIDE3699	4.1e-188	664.1	Bacteria			2.1.1.137	ko:K07755					ko00000,ko01000				Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_03233	330214.NIDE3700	2.6e-45	188.0	Bacteria				ko:K03892					ko00000,ko03000				Bacteria	COG0640@1,COG0640@2	NA|NA|NA	K	DNA-binding transcription factor activity
MAG.T21.41_03234	330214.NIDE3701	3.5e-167	594.3	Bacteria													Bacteria	COG0535@1,COG0535@2	NA|NA|NA	I	radical SAM domain protein
MAG.T21.41_03235	330214.NIDE3702	2.7e-160	571.6	Nitrospirae				ko:K03306					ko00000	2.A.20			Bacteria	3J1D1@40117,COG0306@1,COG0306@2	NA|NA|NA	P	Phosphate transporter family
MAG.T21.41_03236	330214.NIDE3703	3.2e-254	884.0	Bacteria													Bacteria	2ESX4@1,33KFG@2	NA|NA|NA		
MAG.T21.41_03237	330214.NIDE3704	2.9e-69	268.1	Bacteria	aoxA		1.20.2.1,1.20.9.1	ko:K08355					ko00000,ko01000,ko02000	5.A.3.6			Bacteria	COG0723@1,COG0723@2	NA|NA|NA	C	oxidoreductase activity, acting on diphenols and related substances as donors
MAG.T21.41_03238	330214.NIDE3705	0.0	1469.9	Bacteria	aoxB		1.20.2.1,1.20.9.1	ko:K08356					ko00000,ko01000,ko02000	5.A.3.6			Bacteria	COG0243@1,COG0243@2	NA|NA|NA	C	molybdopterin cofactor binding
MAG.T21.41_03240	330214.NIDE3711	4.6e-159	567.4	Bacteria	hflK			ko:K04088		M00742			ko00000,ko00002,ko01000				Bacteria	COG0330@1,COG0330@2	NA|NA|NA	O	stress-induced mitochondrial fusion
MAG.T21.41_03241	330214.NIDE3712	1e-135	489.6	Bacteria	hflC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564		ko:K04087		M00742			ko00000,ko00002,ko01000				Bacteria	COG0330@1,COG0330@2	NA|NA|NA	O	stress-induced mitochondrial fusion
MAG.T21.41_03242	330214.NIDE3713	7.2e-279	966.1	Nitrospirae	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0CI@40117,COG2759@1,COG2759@2	NA|NA|NA	F	Formate--tetrahydrofolate ligase
MAG.T21.41_03243	330214.NIDE3714	6.1e-164	583.6	Nitrospirae				ko:K21471,ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	3J0N3@40117,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase family M23
MAG.T21.41_03245	330214.NIDE2319	2.1e-163	582.0	Nitrospirae	flgK			ko:K02396	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0M9@40117,COG1256@1,COG1256@2,COG4786@1,COG4786@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T21.41_03247	330214.NIDE2317	5.3e-39	166.8	Bacteria	flgM	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040				ko00000,ko00001,ko02035				Bacteria	COG2747@1,COG2747@2	NA|NA|NA	N	bacterial-type flagellum organization
MAG.T21.41_03248	330214.NIDE2316	2e-36	158.3	Bacteria	flgJ			ko:K02395,ko:K08309					ko00000,ko01000,ko01011,ko02035		GH23		Bacteria	COG3951@1,COG3951@2	NA|NA|NA	MNO	Flagellar rod assembly protein muramidase FlgJ
MAG.T21.41_03249	330214.NIDE2315	1.4e-205	722.2	Nitrospirae	flgI			ko:K02394	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0MB@40117,COG1706@1,COG1706@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MAG.T21.41_03250	330214.NIDE2314	5.9e-107	393.7	Nitrospirae	flgH			ko:K01991,ko:K02393	ko02026,ko02040,map02026,map02040				ko00000,ko00001,ko02000,ko02035	1.B.18			Bacteria	3J16G@40117,COG2063@1,COG2063@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MAG.T21.41_03251	330214.NIDE2313	3.8e-113	414.5	Bacteria	flgA			ko:K02279,ko:K02386	ko02040,map02040				ko00000,ko00001,ko02035,ko02044				Bacteria	COG1261@1,COG1261@2	NA|NA|NA	N	bacterial-type flagellum organization
MAG.T21.41_03252	330214.NIDE2312	4e-139	500.7	Nitrospirae	flgG			ko:K02392	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J0IQ@40117,COG4786@1,COG4786@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T21.41_03253	330214.NIDE2311	8.4e-118	429.9	Nitrospirae	flgF			ko:K02391,ko:K02392	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	3J16I@40117,COG4786@1,COG4786@2	NA|NA|NA	N	Flagellar basal body rod FlgEFG protein C-terminal
MAG.T21.41_03254	330214.NIDE2310	9.8e-70	270.4	Bacteria			2.7.7.65	ko:K13590	ko04112,map04112				ko00000,ko00001,ko01000				Bacteria	COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase activity
MAG.T21.41_03255	330214.NIDE2309	1.1e-125	456.1	Nitrospirae	fliA			ko:K02405,ko:K03093	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111				ko00000,ko00001,ko02035,ko03021				Bacteria	3J0NW@40117,COG1191@1,COG1191@2	NA|NA|NA	K	Sigma-70, region 4
MAG.T21.41_03256	330214.NIDE2308	3.2e-145	521.2	Nitrospirae	fleN			ko:K02282,ko:K04562					ko00000,ko02035,ko02044				Bacteria	3J0JR@40117,COG0455@1,COG0455@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T21.41_03257	330214.NIDE2307	1.8e-181	642.1	Nitrospirae	flhF			ko:K02404					ko00000,ko02035				Bacteria	3J162@40117,COG1419@1,COG1419@2	NA|NA|NA	N	SRP54-type protein, GTPase domain
MAG.T21.41_03258	330214.NIDE2306	1.3e-165	589.0	Nitrospirae	flhA			ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	3J0B1@40117,COG1298@1,COG1298@2	NA|NA|NA	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MAG.T21.41_03259	1205680.CAKO01000032_gene2104	8.6e-88	330.9	Rhodospirillales													Bacteria	1RGME@1224,2JXMG@204441,2U7Z1@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_03260	1038858.AXBA01000018_gene1225	1.9e-89	336.3	Xanthobacteraceae				ko:K10107	ko02010,map02010	M00249			ko00000,ko00001,ko00002,ko02000	3.A.1.101			Bacteria	1R3ZY@1224,2U0I2@28211,3F1I9@335928,COG3524@1,COG3524@2	NA|NA|NA	M	COG3524 Capsule polysaccharide export protein
MAG.T21.41_03261	1317124.DW2_18269	8.1e-39	166.0	Alphaproteobacteria	hvrA			ko:K03746					ko00000,ko03036,ko03400				Bacteria	1N801@1224,2UF4Y@28211,COG2916@1,COG2916@2	NA|NA|NA	S	DNA-binding protein, H-NS
MAG.T21.41_03263	1081640.AGFU01000090_gene2765	9.9e-217	760.0	Sphingomonadales													Bacteria	1NRBC@1224,2K96H@204457,2TSI9@28211,COG1479@1,COG1479@2	NA|NA|NA	S	Protein of unknown function (DUF1524)
MAG.T21.41_03264	1122214.AQWH01000017_gene4641	2e-21	107.5	Alphaproteobacteria													Bacteria	1N7N6@1224,2EBH9@1,2UFCX@28211,335HS@2	NA|NA|NA		
MAG.T21.41_03265	247634.GPB2148_2354	8.8e-27	125.6	unclassified Gammaproteobacteria	phoH			ko:K07175					ko00000				Bacteria	1J555@118884,1MUX1@1224,1RMQN@1236,COG1875@1,COG1875@2	NA|NA|NA	T	phosphate starvation-inducible protein PhoH
MAG.T21.41_03266	443143.GM18_4371	5.1e-27	126.7	Proteobacteria													Bacteria	1N0DD@1224,COG1396@1,COG1396@2	NA|NA|NA	K	Protein of unknown function (DUF2442)
MAG.T21.41_03267	526225.Gobs_0394	1.2e-23	117.5	Bacteria	lgtA			ko:K00786					ko00000,ko01000				Bacteria	COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_03268	1074488.AGBX01000007_gene2061	3.3e-59	235.3	Dermabacteraceae				ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2HXAQ@201174,4FCEY@85020,COG1132@1,COG1132@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T21.41_03269	330214.NIDE2929	3.8e-307	1060.1	Nitrospirae	ftsH		3.4.21.53	ko:K03798,ko:K04076,ko:K13525,ko:K17681	ko04141,ko05134,map04141,map05134	M00400,M00403,M00742			ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03029,ko03110,ko04131,ko04147	3.A.16.1			Bacteria	3J0AG@40117,COG0465@1,COG0465@2	NA|NA|NA	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAG.T21.41_03270	330214.NIDE2930	4.3e-164	583.9	Nitrospirae	czcD			ko:K16264					ko00000,ko02000	2.A.4.1			Bacteria	3J11Z@40117,COG1230@1,COG1230@2	NA|NA|NA	P	Cation efflux family
MAG.T21.41_03271	330214.NIDE2933	6.6e-168	596.7	Bacteria	cobW												Bacteria	COG0523@1,COG0523@2	NA|NA|NA	P	cobalamin synthesis protein
MAG.T21.41_03272	330214.NIDE2934	1e-99	369.4	Nitrospirae	ybjG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042221,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K06153,ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011			iEC042_1314.EC042_0932	Bacteria	3J155@40117,COG0671@1,COG0671@2	NA|NA|NA	I	Acid phosphatase homologues
MAG.T21.41_03273	330214.NIDE2937	2.5e-65	254.6	Bacteria													Bacteria	2DNQI@1,32YKA@2	NA|NA|NA		
MAG.T21.41_03278	1532558.JL39_27625	2.3e-48	199.1	Rhizobiaceae			6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000				Bacteria	1NMSE@1224,2VDME@28211,4BBRJ@82115,COG0388@1,COG0388@2	NA|NA|NA	S	Carbon-nitrogen hydrolase
MAG.T21.41_03279	933262.AXAM01000083_gene773	1.2e-19	101.7	Desulfobacterales	hicA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K07339					ko00000,ko01000,ko02048				Bacteria	1NHPS@1224,2MP3Q@213118,2WSQY@28221,42XAS@68525,COG1724@1,COG1724@2	NA|NA|NA	N	HicA toxin of bacterial toxin-antitoxin,
MAG.T21.41_03282	330214.NIDE2953	0.0	1479.2	Bacteria			3.1.4.4	ko:K01115	ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231		R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000,ko04131				Bacteria	COG1502@1,COG1502@2	NA|NA|NA	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MAG.T21.41_03284	479434.Sthe_2721	8.8e-64	250.0	Chloroflexi	dcdA		3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044				Bacteria	2G7AC@200795,COG2131@1,COG2131@2	NA|NA|NA	F	MafB19-like deaminase
MAG.T21.41_03286	55601.VANGNB10_cII0523c	3.4e-33	148.3	Bacteria													Bacteria	2EK6N@1,33DX1@2	NA|NA|NA		
MAG.T21.41_03287	1150621.SMUL_1243	5.3e-18	97.1	Bacteria				ko:K06218					ko00000,ko02048				Bacteria	COG2026@1,COG2026@2	NA|NA|NA	DJ	nuclease activity
MAG.T21.41_03288	1565314.OA34_03655	4.6e-08	63.9	Epsilonproteobacteria													Bacteria	1QTMF@1224,2B33V@1,2YQ90@29547,31VRH@2,42VGS@68525	NA|NA|NA	S	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T21.41_03289	1121271.AUCM01000016_gene2611	8.4e-50	203.0	Alphaproteobacteria													Bacteria	1R50R@1224,2CYHT@1,2TUKY@28211,32T48@2	NA|NA|NA		
MAG.T21.41_03290	1121022.ABENE_07140	5.4e-136	490.7	Caulobacterales													Bacteria	1MUER@1224,2KFYE@204458,2TQTP@28211,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase IS116/IS110/IS902 family
MAG.T21.41_03291	330214.NIDE0644	0.0	1309.3	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4773@1,COG4773@2	NA|NA|NA	P	Receptor
MAG.T21.41_03292	330214.NIDE0645	6.9e-175	620.2	Bacteria													Bacteria	COG3182@1,COG3182@2	NA|NA|NA	E	Iron-regulated membrane protein
MAG.T21.41_03293	330214.NIDE0648	0.0	1443.7	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_03295	857087.Metme_2895	8.6e-185	654.1	Methylococcales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1QTT0@1224,1RNBT@1236,1XEVS@135618,COG4773@1,COG4773@2	NA|NA|NA	P	TIGRFAM TonB-dependent siderophore receptor
MAG.T21.41_03297	330214.NIDE0650	0.0	1223.8	Bacteria	iutA			ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG4771@2	NA|NA|NA	P	transport
MAG.T21.41_03298	330214.NIDE0660	1.5e-206	725.3	Nitrospirae				ko:K07133					ko00000				Bacteria	3J14P@40117,COG1373@1,COG1373@2	NA|NA|NA	S	AAA domain
MAG.T21.41_03301	330214.NIDE4278	1e-96	359.8	Bacteria													Bacteria	2DC00@1,2ZC4V@2	NA|NA|NA		
MAG.T21.41_03302	330214.NIDE4279	2.6e-148	531.6	Nitrospirae													Bacteria	3J0KK@40117,COG1994@1,COG1994@2	NA|NA|NA	S	Peptidase family M50
MAG.T21.41_03303	330214.NIDE4281	2.1e-125	455.3	Nitrospirae	gloB		3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000				Bacteria	3J17T@40117,COG0491@1,COG0491@2,COG1396@1,COG1396@2	NA|NA|NA	K	Metallo-beta-lactamase superfamily
MAG.T21.41_03304	330214.NIDE4282	4.5e-237	827.0	Nitrospirae	ymxG			ko:K07263					ko00000,ko01000,ko01002				Bacteria	3J0I5@40117,COG0612@1,COG0612@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03305	330214.NIDE4283	7.2e-265	919.5	Nitrospirae	pqqL			ko:K07263					ko00000,ko01000,ko01002				Bacteria	3J0BY@40117,COG0612@1,COG0612@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03306	330214.NIDE4284	9.7e-115	419.5	Nitrospirae	gph		3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	3J0QE@40117,COG0546@1,COG0546@2	NA|NA|NA	S	HAD-hyrolase-like
MAG.T21.41_03308	330214.NIDE4286	2.7e-229	801.2	Nitrospirae	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAF987.Gmet_0122	Bacteria	3J0XM@40117,COG0469@1,COG0469@2	NA|NA|NA	G	Belongs to the pyruvate kinase family
MAG.T21.41_03309	330214.NIDE4287	0.0	1389.0	Bacteria	pfkA		2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019				Bacteria	COG0205@1,COG0205@2,COG0406@1,COG0406@2	NA|NA|NA	G	6-phosphofructokinase activity
MAG.T21.41_03310	330214.NIDE4288	4e-54	217.6	Bacteria		GO:0005575,GO:0005576		ko:K03628,ko:K15125	ko03018,ko05133,map03018,map05133				ko00000,ko00001,ko00536,ko03019,ko03021				Bacteria	COG4290@1,COG4290@2	NA|NA|NA	F	endoribonuclease activity
MAG.T21.41_03311	330214.NIDE1360	5.9e-63	246.9	Nitrospirae	amt			ko:K03320					ko00000,ko02000	1.A.11		iHN637.CLJU_c42670,iYO844.BSU36510	Bacteria	3J0IS@40117,COG0004@1,COG0004@2	NA|NA|NA	P	Ammonium Transporter Family
MAG.T21.41_03312	330214.NIDE1361	9.3e-53	212.6	Nitrospirae	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045848,GO:0046890,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363		ko:K02589,ko:K02590,ko:K03320,ko:K04751,ko:K04752	ko02020,map02020				ko00000,ko00001,ko02000	1.A.11			Bacteria	3J0P1@40117,COG0347@1,COG0347@2	NA|NA|NA	K	Nitrogen regulatory protein P-II
MAG.T21.41_03314	330214.NIDE1029	3.8e-135	488.0	Bacteria	nosX		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	COG1477@1,COG1477@2	NA|NA|NA	H	protein flavinylation
MAG.T21.41_03315	330214.NIDE1031	3.2e-50	205.7	Nitrospirae				ko:K03832					ko00000,ko02000	2.C.1.1			Bacteria	3J0U0@40117,COG0810@1,COG0810@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03316	330214.NIDE1032	5e-55	220.3	Bacteria	exbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03559					ko00000,ko02000	1.A.30.2.1			Bacteria	COG0848@1,COG0848@2	NA|NA|NA	U	biopolymer transport protein
MAG.T21.41_03317	330214.NIDE1033	6.1e-65	253.4	Bacteria	exbB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03561,ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.1,1.A.30.2.2			Bacteria	COG0811@1,COG0811@2	NA|NA|NA	U	bacteriocin transport
MAG.T21.41_03318	330214.NIDE1034	1.9e-169	602.1	Bacteria	potA		3.6.3.30	ko:K02010	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10			Bacteria	COG3842@1,COG3842@2	NA|NA|NA	P	ATPase activity
MAG.T21.41_03319	330214.NIDE1035	2.2e-253	881.3	Bacteria	sfuB			ko:K02011	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	COG1178@1,COG1178@2	NA|NA|NA	P	thiamine transport
MAG.T21.41_03320	330214.NIDE1036	1.1e-163	582.8	Bacteria	fbpA	GO:0005575,GO:0005623,GO:0042597,GO:0044464		ko:K02012	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10		iJN678.sufA	Bacteria	COG1840@1,COG1840@2	NA|NA|NA	P	iron ion homeostasis
MAG.T21.41_03321	330214.NIDE1037	2e-77	295.0	Nitrospirae	fur	GO:0000976,GO:0001067,GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K03711					ko00000,ko03000				Bacteria	3J0UN@40117,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T21.41_03324	330214.NIDE1040	5.9e-84	317.4	Nitrospirae				ko:K02282					ko00000,ko02035,ko02044				Bacteria	3J12Q@40117,COG2197@1,COG2197@2	NA|NA|NA	K	Product type r regulator
MAG.T21.41_03325	330214.NIDE1041	1.3e-266	925.2	Bacteria	ypwA	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.17.19	ko:K01299,ko:K03281					ko00000,ko01000,ko01002	2.A.49			Bacteria	COG2317@1,COG2317@2	NA|NA|NA	E	metallocarboxypeptidase activity
MAG.T21.41_03326	330214.NIDE1042	6.8e-100	370.2	Nitrospirae	yrrM		2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1C3@40117,COG4122@1,COG4122@2	NA|NA|NA	S	Methyltransferase domain
MAG.T21.41_03327	330214.NIDE1043	2.5e-140	505.0	Bacteria	yetK												Bacteria	COG0697@1,COG0697@2	NA|NA|NA	EG	spore germination
MAG.T21.41_03328	330214.NIDE0936	1.6e-152	546.2	Nitrospirae													Bacteria	3J12P@40117,COG4585@1,COG4585@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03329	330214.NIDE0935	1.1e-81	309.7	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_03330	330214.NIDE1046	0.0	1865.1	Bacteria	barA		2.7.13.3	ko:K07636	ko02020,map02020	M00434			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG0642@1,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2205@2,COG4191@1,COG4191@2	NA|NA|NA	T	PhoQ Sensor
MAG.T21.41_03331	330214.NIDE1047	1.3e-233	815.5	Bacteria				ko:K02481,ko:K02584,ko:K07712	ko02020,map02020	M00497			ko00000,ko00001,ko00002,ko02022,ko03000				Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_03332	330214.NIDE1051	1.3e-35	155.6	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_03333	330214.NIDE1052	6.1e-72	276.6	Bacteria													Bacteria	COG4319@1,COG4319@2	NA|NA|NA		
MAG.T21.41_03334	330214.NIDE1053	1.1e-46	192.6	Bacteria													Bacteria	2FBTK@1,343YA@2	NA|NA|NA		
MAG.T21.41_03336	330214.NIDE1055	1.6e-26	125.6	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_03338	1283299.AUKG01000003_gene644	4.6e-07	60.5	Actinobacteria													Bacteria	2CA4F@1,2GRQ2@201174,33DCB@2	NA|NA|NA		
MAG.T21.41_03340	330214.NIDE1059	1.6e-170	605.5	Bacteria	gcvT		1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	COG0404@1,COG0404@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine
MAG.T21.41_03341	330214.NIDE1060	2.1e-48	198.4	Bacteria													Bacteria	COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase activity
MAG.T21.41_03342	330214.NIDE1061	7.6e-92	343.2	Bacteria	sscB												Bacteria	COG3063@1,COG3063@2	NA|NA|NA	NU	photosynthesis
MAG.T21.41_03343	330214.NIDE1062	2.9e-145	521.2	Bacteria	thi4	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576		ko:K03146	ko00730,ko01100,map00730,map01100		R10685	RC00033,RC03253,RC03254	ko00000,ko00001				Bacteria	COG1635@1,COG1635@2	NA|NA|NA	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MAG.T21.41_03344	330214.NIDE1063	1.7e-284	984.6	Nitrospirae	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c45100	Bacteria	3J0AY@40117,COG0422@1,COG0422@2	NA|NA|NA	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MAG.T21.41_03345	330214.NIDE2853	2.2e-37	163.3	Bacteria	sypH												Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_03347	203122.Sde_0148	2.6e-50	206.5	Alteromonadaceae													Bacteria	1R3X9@1224,1S184@1236,465Z5@72275,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_03348	370438.PTH_0500	1.2e-10	72.0	Clostridia													Bacteria	1W48M@1239,255K1@186801,COG2002@1,COG2002@2	NA|NA|NA	K	SpoVT / AbrB like domain
MAG.T21.41_03349	330214.NIDE2494	2.7e-51	208.0	Bacteria				ko:K06186					ko00000,ko02000	1.B.33.1			Bacteria	COG2913@1,COG2913@2	NA|NA|NA	J	Gram-negative-bacterium-type cell outer membrane assembly
MAG.T21.41_03350	330214.NIDE2497	2e-92	345.1	Nitrospirae	ppiB		5.2.1.8	ko:K01802,ko:K03768					ko00000,ko01000,ko03110				Bacteria	3J18H@40117,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T21.41_03351	330214.NIDE2498	4.4e-251	873.6	Bacteria				ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	COG2333@1,COG2333@2	NA|NA|NA	N	competence protein COMEC
MAG.T21.41_03352	330214.NIDE2502	0.0	1270.8	Nitrospirae			2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	3J0XA@40117,COG0286@1,COG0286@2	NA|NA|NA	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03353	397945.Aave_3358	6.9e-58	231.5	Comamonadaceae	hsdS		3.1.21.3	ko:K01154					ko00000,ko01000,ko02048				Bacteria	1Q4FB@1224,2VR1G@28216,4AF39@80864,COG0732@1,COG0732@2	NA|NA|NA	L	Type I restriction modification DNA specificity domain
MAG.T21.41_03354	330214.NIDE2504	6.5e-57	226.5	Bacteria		GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360											Bacteria	COG4679@1,COG4679@2	NA|NA|NA	K	PFAM Phage derived protein Gp49-like (DUF891)
MAG.T21.41_03355	330214.NIDE2505	1.7e-61	241.9	Nitrospirae													Bacteria	3J1D7@40117,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_03356	330214.NIDE2506	0.0	1812.3	Nitrospirae			3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	3J0QC@40117,COG0610@1,COG0610@2	NA|NA|NA	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03357	330214.NIDE0721	3.2e-119	434.5	Bacteria	spoIVFB			ko:K06402					ko00000,ko01000,ko01002				Bacteria	COG1994@1,COG1994@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_03358	330214.NIDE0720	3.3e-129	468.0	Bacteria													Bacteria	COG4714@1,COG4714@2	NA|NA|NA	EGP	membrane-anchored protein conserved in bacteria
MAG.T21.41_03359	330214.NIDE0505	8.9e-38	162.9	Bacteria													Bacteria	COG4446@1,COG4446@2	NA|NA|NA	P	Protein conserved in bacteria
MAG.T21.41_03360	330214.NIDE0719	7.5e-192	676.4	Bacteria													Bacteria	28IX1@1,2Z8V3@2	NA|NA|NA	S	Protein of unknown function (DUF2914)
MAG.T21.41_03363	330214.NIDE0715	1.6e-98	365.5	Bacteria													Bacteria	2E469@1,32Z27@2	NA|NA|NA		
MAG.T21.41_03366	330214.NIDE0701	3.9e-176	624.0	Nitrospirae	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K00795,ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006			iPC815.YPO3176,iSFV_1184.SFV_0386	Bacteria	3J0H1@40117,COG0142@1,COG0142@2	NA|NA|NA	H	Polyprenyl synthetase
MAG.T21.41_03367	330214.NIDE0700	1.9e-178	631.7	Nitrospirae	dfrA		1.1.1.219	ko:K00091					ko00000,ko01000				Bacteria	3J0T9@40117,COG0451@1,COG0451@2	NA|NA|NA	M	NmrA-like family
MAG.T21.41_03368	330214.NIDE0699	5.4e-123	447.2	Nitrospirae	cruF		5.5.1.19	ko:K22502	ko00906,map00906		R03824,R05341	RC01004	ko00000,ko00001,ko01000				Bacteria	3J195@40117,COG2324@1,COG2324@2	NA|NA|NA	S	Carotenoid biosynthesis protein
MAG.T21.41_03369	330214.NIDE0698	1.5e-96	359.0	Bacteria	copM			ko:K03611					ko00000,ko03110	5.A.2.1			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_03371	330214.NIDE0695	3.2e-56	224.6	Nitrospirae	yvlD			ko:K08972					ko00000				Bacteria	3J19X@40117,COG1950@1,COG1950@2	NA|NA|NA	S	Mycobacterial 4 TMS phage holin, superfamily IV
MAG.T21.41_03377	330214.NIDE1735	4.9e-114	417.9	Bacteria	VP1245												Bacteria	COG0784@1,COG0784@2	NA|NA|NA	T	Response regulator, receiver
MAG.T21.41_03378	330214.NIDE1736	1.2e-113	416.0	Bacteria				ko:K07025					ko00000				Bacteria	COG1011@1,COG1011@2	NA|NA|NA	S	phosphatase activity
MAG.T21.41_03379	330214.NIDE1737	2.3e-117	428.3	Nitrospirae	cobB	GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564		ko:K12410					ko00000,ko01000				Bacteria	3J15J@40117,COG0846@1,COG0846@2	NA|NA|NA	K	Belongs to the sirtuin family. Class
MAG.T21.41_03380	330214.NIDE1738	2e-239	834.7	Nitrospirae	panE		1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2643	Bacteria	3J0S5@40117,COG1893@1,COG1893@2,COG2041@1,COG2041@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MAG.T21.41_03381	330214.NIDE1739	2.2e-198	698.4	Bacteria	norM			ko:K03327					ko00000,ko02000	2.A.66.1			Bacteria	COG0534@1,COG0534@2	NA|NA|NA	V	drug transmembrane transporter activity
MAG.T21.41_03382	330214.NIDE1740	5.3e-257	893.3	Bacteria	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Bacteria	COG2251@1,COG2251@2	NA|NA|NA		
MAG.T21.41_03385	330214.NIDE1742	0.0	4847.0	Bacteria													Bacteria	COG0318@1,COG0318@2,COG1020@1,COG1020@2	NA|NA|NA	Q	D-alanine [D-alanyl carrier protein] ligase activity
MAG.T21.41_03386	330214.NIDE1743	9.2e-271	939.1	Bacteria				ko:K06160	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.113.2			Bacteria	COG4615@1,COG4615@2	NA|NA|NA	V	microcin transport
MAG.T21.41_03387	330214.NIDE1744	1.5e-74	286.2	Bacteria	hetI		2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000				Bacteria	COG2091@1,COG2091@2	NA|NA|NA	H	lysine biosynthetic process via aminoadipic acid
MAG.T21.41_03388	330214.NIDE1745	5.6e-65	253.8	Nitrospirae	tadA	GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360	3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5,6.3.4.19	ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K04075,ko:K11991	ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120		R00974,R01411,R01676,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223	RC00074,RC00204,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634	ko00000,ko00001,ko01000,ko01002,ko01011,ko03016				Bacteria	3J0PE@40117,COG0590@1,COG0590@2	NA|NA|NA	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MAG.T21.41_03389	330214.NIDE1746	8.3e-129	466.8	Bacteria				ko:K18682	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	COG4372@1,COG4372@2,COG5343@1,COG5343@2	NA|NA|NA	S	Anti-sigma-K factor rskA
MAG.T21.41_03390	330214.NIDE1747	3.7e-92	344.4	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_03391	330214.NIDE1748	1.9e-131	475.7	Bacteria													Bacteria	COG1819@1,COG1819@2	NA|NA|NA	CG	transferase activity, transferring hexosyl groups
MAG.T21.41_03396	330214.NIDE3139	5.4e-175	620.9	Bacteria				ko:K03287					ko00000	1.B.17			Bacteria	COG1538@1,COG1538@2	NA|NA|NA	MU	efflux transmembrane transporter activity
MAG.T21.41_03397	330214.NIDE3138	6.3e-92	344.0	Bacteria													Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_03398	330214.NIDE3137	2.1e-180	638.6	Bacteria				ko:K01993,ko:K16922					ko00000,ko01002				Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_03399	330214.NIDE2582	5.3e-41	173.3	Nitrospirae	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	3J0FE@40117,COG0587@1,COG0587@2	NA|NA|NA	L	DNA-directed DNA polymerase
MAG.T21.41_03400	330214.NIDE2583	5.6e-175	620.2	Nitrospirae	accA	GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN678.accA,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	Bacteria	3J0CN@40117,COG0825@1,COG0825@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MAG.T21.41_03401	330214.NIDE2584	1.2e-143	515.8	Bacteria													Bacteria	COG2067@1,COG2067@2	NA|NA|NA	I	long-chain fatty acid transporting porin activity
MAG.T21.41_03417	644282.Deba_2236	1e-16	94.7	Deltaproteobacteria				ko:K14059					ko00000				Bacteria	1MVZB@1224,2WRE7@28221,42W21@68525,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_03419	1476876.JOJO01000002_gene6628	4.1e-20	104.8	Actinobacteria													Bacteria	2GVIF@201174,COG2230@1,COG2230@2	NA|NA|NA	M	Methyltransferase domain
MAG.T21.41_03421	243159.AFE_3196	1.4e-14	87.4	Gammaproteobacteria	tnsD												Bacteria	1N87H@1224,1RS9H@1236,COG3677@1,COG3677@2	NA|NA|NA	L	Tn7-like transposition protein D
MAG.T21.41_03422	43989.cce_1263	1.5e-14	87.0	Cyanothece													Bacteria	1G4BK@1117,3KI2S@43988,COG1474@1,COG1474@2	NA|NA|NA	LO	Bacterial TniB protein
MAG.T21.41_03424	330214.NIDE2426	1.7e-67	262.7	Nitrospirae													Bacteria	3J0JU@40117,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T21.41_03425	1437448.AZRT01000113_gene4320	2.8e-25	120.9	Proteobacteria				ko:K07090					ko00000				Bacteria	1RBHH@1224,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
MAG.T21.41_03426	595494.Tola_1286	2.3e-211	741.9	Gammaproteobacteria	pykF4		2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	1NNNX@1224,1RYF5@1236,COG0469@1,COG0469@2	NA|NA|NA	G	Pyruvate kinase
MAG.T21.41_03427	861299.J421_3028	1.8e-18	100.5	Gemmatimonadetes													Bacteria	1ZT4C@142182,28M10@1,301VW@2	NA|NA|NA	S	Domain of unknown function (DUF4403)
MAG.T21.41_03428	330214.NIDE2763	7e-47	193.0	Nitrospirae		GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	3J0QD@40117,COG0011@1,COG0011@2	NA|NA|NA	S	Thiamine-binding protein
MAG.T21.41_03429	330214.NIDE2764	8.6e-103	379.8	Bacteria	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	Bacteria	COG1648@1,COG1648@2	NA|NA|NA	H	precorrin-2 dehydrogenase activity
MAG.T21.41_03430	330214.NIDE2765	4.3e-69	267.3	Bacteria	cycH		3.4.21.105	ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007	ko02025,map02025				ko00000,ko00001,ko01000,ko01002,ko02000	1.B.55.3			Bacteria	COG4235@1,COG4235@2	NA|NA|NA	O	cytochrome complex assembly
MAG.T21.41_03431	330214.NIDE2766	1.8e-101	375.2	Nitrospirae	MA20_20605												Bacteria	3J0VM@40117,COG1403@1,COG1403@2	NA|NA|NA	L	HNH nucleases
MAG.T21.41_03432	330214.NIDE2767	1.3e-46	192.2	Nitrospirae			1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	3J1E7@40117,COG2146@1,COG2146@2	NA|NA|NA	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03434	330214.NIDE2770	5.3e-81	307.0	Bacteria													Bacteria	COG2105@1,COG2105@2	NA|NA|NA	F	PFAM AIG2 family protein
MAG.T21.41_03435	330214.NIDE2772	3e-56	224.2	Bacteria	fdx4												Bacteria	COG3411@1,COG3411@2	NA|NA|NA	C	Ferredoxin
MAG.T21.41_03436	330214.NIDE2773	5.1e-70	270.4	Bacteria	moaB		2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100		R09726	RC00002	ko00000,ko00001,ko01000				Bacteria	COG0521@1,COG0521@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T21.41_03437	330214.NIDE2775	2.1e-65	255.0	Nitrospirae				ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	3J1AQ@40117,COG2905@1,COG2905@2	NA|NA|NA	T	Domain in cystathionine beta-synthase and other proteins.
MAG.T21.41_03438	330214.NIDE2776	1.2e-183	649.0	Nitrospirae			1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	3J13T@40117,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T21.41_03439	330214.NIDE2777	2.7e-158	564.7	Bacteria	yddE		5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835			ko00000,ko00001,ko00002,ko01000				Bacteria	COG0384@1,COG0384@2	NA|NA|NA	S	isomerase activity
MAG.T21.41_03440	330214.NIDE2778	3.3e-231	807.4	Bacteria													Bacteria	COG0535@1,COG0535@2	NA|NA|NA	I	radical SAM domain protein
MAG.T21.41_03442	330214.NIDE2780	0.0	1260.4	Bacteria													Bacteria	COG1032@1,COG1032@2	NA|NA|NA	C	radical SAM domain protein
MAG.T21.41_03443	330214.NIDE2781	0.0	1204.1	Bacteria													Bacteria	COG1032@1,COG1032@2	NA|NA|NA	C	radical SAM domain protein
MAG.T21.41_03444	1009370.ALO_09639	5.3e-37	160.2	Negativicutes		GO:0005575,GO:0005576		ko:K09771					ko00000,ko02000	2.A.7.26			Bacteria	1V6YJ@1239,4H5CN@909932,COG1742@1,COG1742@2	NA|NA|NA	S	UPF0060 membrane protein
MAG.T21.41_03445	710686.Mycsm_01180	1.8e-73	282.3	Mycobacteriaceae													Bacteria	23CAG@1762,2GX9Z@201174,COG4185@1,COG4185@2	NA|NA|NA	S	Zeta toxin
MAG.T21.41_03446	710686.Mycsm_01181	2.1e-27	128.6	Mycobacteriaceae													Bacteria	23DVG@1762,2FBTW@1,2H64G@201174,321XM@2	NA|NA|NA	S	Antitoxin Phd_YefM, type II toxin-antitoxin system
MAG.T21.41_03447	1487953.JMKF01000045_gene2977	1.8e-14	85.1	Oscillatoriales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1GPYF@1117,1HI63@1150,COG4774@1,COG4774@2	NA|NA|NA	P	TonB dependent receptor
MAG.T21.41_03448	1112274.KI911560_gene250	1.2e-107	396.7	Nitrosomonadales													Bacteria	1MW2S@1224,2KKTP@206350,2VHU6@28216,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_03449	1123261.AXDW01000003_gene2029	4.6e-87	328.2	Xanthomonadales				ko:K07006					ko00000				Bacteria	1MWG9@1224,1SE6U@1236,1X9X5@135614,COG3576@1,COG3576@2	NA|NA|NA	S	Pfam:Pyridox_oxidase
MAG.T21.41_03451	472759.Nhal_1802	9e-88	331.3	Gammaproteobacteria													Bacteria	1NMVC@1224,1SVSQ@1236,COG2138@1,COG2138@2	NA|NA|NA	S	Cobalamin (vitamin B12) biosynthesis CbiX protein
MAG.T21.41_03454	1211115.ALIQ01000245_gene3681	1.3e-40	172.9	Beijerinckiaceae	pfrI			ko:K03088					ko00000,ko03021				Bacteria	1RFMB@1224,2UFCA@28211,3NCFU@45404,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70 region 2
MAG.T21.41_03455	1207063.P24_01860	5.5e-59	235.0	Rhodospirillales	fecR			ko:K07165					ko00000				Bacteria	1MZCK@1224,2JS5V@204441,2U7GV@28211,COG3712@1,COG3712@2	NA|NA|NA	PT	Domain of unknown function (DUF4880)
MAG.T21.41_03457	330214.NIDE4372	5.1e-95	354.0	Bacteria													Bacteria	COG3752@1,COG3752@2	NA|NA|NA	M	Protein of unknown function (DUF1295)
MAG.T21.41_03458	330214.NIDE4370	1.3e-18	98.6	Bacteria													Bacteria	2EQIW@1,33I4X@2	NA|NA|NA		
MAG.T21.41_03459	330214.NIDE4369	7.7e-37	159.5	Bacteria				ko:K07743					ko00000				Bacteria	COG3357@1,COG3357@2	NA|NA|NA	K	Transcriptional regulator containing an HTH domain fused to a Zn-ribbon
MAG.T21.41_03460	330214.NIDE4368	1.8e-262	911.4	Bacteria	tldD2			ko:K03568					ko00000,ko01002				Bacteria	COG0312@1,COG0312@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_03461	330214.NIDE4367	1.9e-229	801.6	Bacteria	tldE2												Bacteria	COG0312@1,COG0312@2	NA|NA|NA	S	metallopeptidase activity
MAG.T21.41_03463	448385.sce2596	2.8e-142	512.3	Myxococcales													Bacteria	1N0A9@1224,2WTRV@28221,2YUFX@29,42YQ0@68525,COG0457@1,COG0457@2	NA|NA|NA	S	COG0457 FOG TPR repeat
MAG.T21.41_03464	330214.NIDE4363	2.1e-130	471.9	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_03465	330214.NIDE4362	2.5e-84	318.2	Nitrospirae			3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	3J0TX@40117,COG1611@1,COG1611@2	NA|NA|NA	S	Belongs to the LOG family
MAG.T21.41_03466	330214.NIDE4361	3e-65	254.6	Bacteria													Bacteria	COG5608@1,COG5608@2	NA|NA|NA	S	Late embryogenesis abundant protein
MAG.T21.41_03467	330214.NIDE4360	3.3e-88	331.3	Bacteria	msrA		1.8.4.11,1.8.4.12	ko:K07304,ko:K12267					ko00000,ko01000				Bacteria	COG0225@1,COG0225@2	NA|NA|NA	O	peptide-methionine (S)-S-oxide reductase activity
MAG.T21.41_03468	330214.NIDE4359	3.4e-52	211.1	Nitrospirae	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06929					ko00000				Bacteria	3J19F@40117,COG1832@1,COG1832@2	NA|NA|NA	S	CoA binding domain
MAG.T21.41_03470	330214.NIDE4356	2.5e-67	261.9	Bacteria													Bacteria	COG0741@1,COG0741@2	NA|NA|NA	M	lytic transglycosylase activity
MAG.T21.41_03471	330214.NIDE4355	6.6e-199	699.9	Nitrospirae				ko:K10907					ko00000,ko01000,ko01007				Bacteria	3J0EV@40117,COG0436@1,COG0436@2	NA|NA|NA	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03472	272134.KB731324_gene3811	2e-54	219.5	Oscillatoriales			2.7.13.3,3.1.3.3	ko:K07315,ko:K11527					ko00000,ko01000,ko01001,ko02022,ko03021				Bacteria	1G3XH@1117,1H73M@1150,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG5000@1,COG5000@2,COG5002@1,COG5002@2	NA|NA|NA	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family
MAG.T21.41_03473	330214.NIDE4038	1.8e-128	465.3	Nitrospirae			4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	3J0TW@40117,COG0720@1,COG0720@2	NA|NA|NA	H	6-pyruvoyl tetrahydropterin synthase
MAG.T21.41_03474	330214.NIDE4039	6.6e-63	247.7	Nitrospirae													Bacteria	3J187@40117,COG0247@1,COG0247@2	NA|NA|NA	C	Protein of unknown function (DUF3501)
MAG.T21.41_03475	330214.NIDE1314	1e-37	162.2	Nitrospirae	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02886	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0BX@40117,COG0090@1,COG0090@2	NA|NA|NA	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MAG.T21.41_03476	330214.NIDE1315	1e-47	195.7	Nitrospirae	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02965	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0MU@40117,COG0185@1,COG0185@2	NA|NA|NA	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MAG.T21.41_03477	330214.NIDE1316	7.5e-53	213.0	Nitrospirae	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02890	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0RZ@40117,COG0091@1,COG0091@2	NA|NA|NA	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MAG.T21.41_03478	330214.NIDE1317	3e-119	434.5	Nitrospirae	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02982	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0AP@40117,COG0092@1,COG0092@2	NA|NA|NA	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MAG.T21.41_03479	330214.NIDE1318	2.5e-71	274.6	Nitrospirae	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02878	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0H7@40117,COG0197@1,COG0197@2	NA|NA|NA	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MAG.T21.41_03480	330214.NIDE1319	1.3e-23	115.2	Bacteria	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02904	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	COG0255@1,COG0255@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uL29 family
MAG.T21.41_03481	330214.NIDE1320	2.3e-38	164.5	Nitrospirae	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02961	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0TQ@40117,COG0186@1,COG0186@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MAG.T21.41_03482	330214.NIDE1321	3.2e-62	244.2	Nitrospirae	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904		ko:K02874	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0JD@40117,COG0093@1,COG0093@2	NA|NA|NA	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MAG.T21.41_03483	330214.NIDE1322	3.3e-47	194.1	Nitrospirae	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02895	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0VK@40117,COG0198@1,COG0198@2	NA|NA|NA	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MAG.T21.41_03484	330214.NIDE1323	2.2e-98	365.2	Nitrospirae	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02931	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0HN@40117,COG0094@1,COG0094@2	NA|NA|NA	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MAG.T21.41_03485	330214.NIDE1325	9.9e-62	242.7	Nitrospirae	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02994	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0SJ@40117,COG0096@1,COG0096@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MAG.T21.41_03486	330214.NIDE1326	5e-87	327.4	Nitrospirae	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02933	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0JB@40117,COG0097@1,COG0097@2	NA|NA|NA	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MAG.T21.41_03487	330214.NIDE1327	3.8e-52	210.7	Nitrospirae	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02881	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0QF@40117,COG0256@1,COG0256@2	NA|NA|NA	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MAG.T21.41_03488	330214.NIDE1328	3.4e-83	314.3	Nitrospirae	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02988	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0M3@40117,COG0098@1,COG0098@2	NA|NA|NA	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MAG.T21.41_03489	330214.NIDE1329	9e-22	109.0	Bacteria	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02907	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	COG1841@1,COG1841@2	NA|NA|NA	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MAG.T21.41_03490	330214.NIDE1330	2e-74	285.0	Nitrospirae	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02876	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0PY@40117,COG0200@1,COG0200@2	NA|NA|NA	J	binds to the 23S rRNA
MAG.T21.41_03491	330214.NIDE1331	3.6e-241	840.5	Nitrospirae	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5			Bacteria	3J0C0@40117,COG0201@1,COG0201@2	NA|NA|NA	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MAG.T21.41_03492	330214.NIDE1332	9.5e-94	349.7	Nitrospirae	adk	GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147			iHN637.CLJU_RS20110	Bacteria	3J0K3@40117,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MAG.T21.41_03493	330214.NIDE1333	4.1e-125	454.1	Nitrospirae	map		3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	3J0GR@40117,COG0024@1,COG0024@2	NA|NA|NA	J	Metallopeptidase family M24
MAG.T21.41_03494	330214.NIDE1334	3.7e-34	150.2	Nitrospirae	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065		ko:K02518					ko00000,ko03012				Bacteria	3J0QB@40117,COG0361@1,COG0361@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MAG.T21.41_03495	330214.NIDE1336	1.3e-58	232.3	Nitrospirae	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02952	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0Q5@40117,COG0099@1,COG0099@2	NA|NA|NA	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MAG.T21.41_03496	330214.NIDE1337	1.9e-62	245.0	Nitrospirae	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02948	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0KE@40117,COG0100@1,COG0100@2	NA|NA|NA	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MAG.T21.41_03497	330214.NIDE1338	1.3e-111	409.1	Nitrospirae	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112		ko:K02986	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0IC@40117,COG0522@1,COG0522@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MAG.T21.41_03498	330214.NIDE1339	6.6e-179	633.3	Nitrospirae	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	3J0AR@40117,COG0202@1,COG0202@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T21.41_03499	330214.NIDE1340	1.1e-61	242.7	Nitrospirae	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02879,ko:K16193	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	3J0TE@40117,COG0203@1,COG0203@2	NA|NA|NA	J	Ribosomal protein L17
MAG.T21.41_03500	330214.NIDE1341	1.5e-93	349.0	Bacteria				ko:K11719					ko00000,ko02000	1.B.42.1			Bacteria	COG5375@1,COG5375@2	NA|NA|NA	S	Protein conserved in bacteria
MAG.T21.41_03501	330214.NIDE1342	2.9e-60	238.4	Nitrospirae	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264		ko:K09774					ko00000,ko02000	1.B.42.1		iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	Bacteria	3J1EG@40117,COG1934@1,COG1934@2	NA|NA|NA	S	OstA-like protein
MAG.T21.41_03502	330214.NIDE1343	9e-123	446.4	Nitrospirae	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320			ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1			Bacteria	3J0GJ@40117,COG1137@1,COG1137@2	NA|NA|NA	S	ABC transporter
MAG.T21.41_03503	330214.NIDE1344	8.5e-263	912.5	Nitrospirae	rpoN			ko:K03092	ko02020,ko05111,map02020,map05111				ko00000,ko00001,ko03021				Bacteria	3J0AT@40117,COG1508@1,COG1508@2	NA|NA|NA	K	Sigma-54 factor, Activator interacting domain (AID)
MAG.T21.41_03504	330214.NIDE1345	1.5e-79	302.4	Nitrospirae	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05808					ko00000,ko03009				Bacteria	3J0V7@40117,COG1544@1,COG1544@2	NA|NA|NA	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MAG.T21.41_03505	330214.NIDE1346	4.7e-149	533.9	Nitrospirae	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K06958					ko00000,ko03019				Bacteria	3J0IK@40117,COG1660@1,COG1660@2	NA|NA|NA	S	Displays ATPase and GTPase activities
MAG.T21.41_03506	330214.NIDE1347	2.4e-30	137.5	Bacteria	racA			ko:K11686,ko:K13640,ko:K18997					ko00000,ko03000,ko03036				Bacteria	COG0789@1,COG0789@2	NA|NA|NA	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MAG.T21.41_03507	330214.NIDE1348	2.6e-184	651.4	Nitrospirae	pilM			ko:K02662					ko00000,ko02035,ko02044				Bacteria	3J177@40117,COG4972@1,COG4972@2	NA|NA|NA	NU	Type IV pilus assembly protein PilM;
MAG.T21.41_03508	330214.NIDE1349	9.2e-90	336.3	Nitrospirae	pilN			ko:K02663					ko00000,ko02035,ko02044				Bacteria	3J1EX@40117,COG3166@1,COG3166@2	NA|NA|NA	NU	Fimbrial assembly protein (PilN)
MAG.T21.41_03509	330214.NIDE1350	1.9e-99	368.6	Nitrospirae	pilO			ko:K02664					ko00000,ko02035,ko02044				Bacteria	3J1BH@40117,COG3167@1,COG3167@2	NA|NA|NA	NU	Pilus assembly protein, PilO
MAG.T21.41_03510	330214.NIDE1351	1.9e-86	325.5	Nitrospirae	pilP			ko:K02664,ko:K02665					ko00000,ko02035,ko02044				Bacteria	3J1AT@40117,COG3168@1,COG3168@2	NA|NA|NA	NU	Pilus assembly protein, PilP
MAG.T21.41_03511	330214.NIDE1352	4.7e-306	1056.6	Nitrospirae	pilQ			ko:K02666					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	3J0Q9@40117,COG4796@1,COG4796@2	NA|NA|NA	U	Secretin and TonB N terminus short domain
MAG.T21.41_03512	330214.NIDE0853	3.2e-127	461.5	Nitrospirae	bamD			ko:K05807,ko:K08309					ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23		Bacteria	3J0UU@40117,COG4105@1,COG4105@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_03513	330214.NIDE0852	7.5e-169	600.1	Nitrospirae	fixC												Bacteria	3J0UE@40117,COG0644@1,COG0644@2	NA|NA|NA	C	oxidoreductase
MAG.T21.41_03514	330214.NIDE0851	1e-123	449.5	Nitrospirae	ccdA			ko:K06196					ko00000,ko02000	5.A.1.2			Bacteria	3J0KU@40117,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein transmembrane region
MAG.T21.41_03515	330214.NIDE0850	7.5e-79	300.1	Bacteria													Bacteria	COG0526@1,COG0526@2	NA|NA|NA	CO	cell redox homeostasis
MAG.T21.41_03516	330214.NIDE0849	1e-100	372.9	Nitrospirae	resA												Bacteria	3J0SG@40117,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin-like
MAG.T21.41_03517	330214.NIDE0848	1e-170	605.9	Nitrospirae	ccsA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678											Bacteria	3J0NY@40117,COG0755@1,COG0755@2	NA|NA|NA	O	Cytochrome C assembly protein
MAG.T21.41_03518	330214.NIDE0847	3e-265	920.6	Nitrospirae	ccs1			ko:K07399					ko00000				Bacteria	3J0N7@40117,COG1333@1,COG1333@2	NA|NA|NA	O	ResB-like family
MAG.T21.41_03519	72658.Bostr.15654s0002.1.p	1.4e-22	113.6	Brassicales		GO:0000018,GO:0000228,GO:0000733,GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006275,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017111,GO:0019219,GO:0019222,GO:0031297,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031593,GO:0031974,GO:0031981,GO:0032392,GO:0033554,GO:0034641,GO:0034645,GO:0036292,GO:0036310,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045005,GO:0045910,GO:0045934,GO:0046483,GO:0048478,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070013,GO:0070530,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090329,GO:0097159,GO:0097617,GO:0140030,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113	3.6.4.12	ko:K14440					ko00000,ko01000,ko03036				Viridiplantae	37JEZ@33090,3GFEV@35493,3HSAQ@3699,COG0553@1,KOG1000@2759	NA|NA|NA	B	SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
MAG.T21.41_03521	278963.ATWD01000003_gene148	1.3e-07	64.7	Acidobacteriia													Bacteria	2JM9G@204432,3Y6XD@57723,COG0790@1,COG0790@2	NA|NA|NA	S	Sel1-like repeats.
MAG.T21.41_03522	330214.NIDE4037	1.1e-178	632.9	Bacteria				ko:K02004,ko:K06994		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG1511@1,COG1511@2	NA|NA|NA	Q	domain protein
MAG.T21.41_03527	330214.NIDE0278	3.4e-261	907.5	Nitrospirae	dnaX		2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	3J0DD@40117,COG2812@1,COG2812@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MAG.T21.41_03528	330214.NIDE0279	1.1e-45	189.1	Nitrospirae	ybaB			ko:K09747					ko00000				Bacteria	3J1EY@40117,COG0718@1,COG0718@2	NA|NA|NA	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MAG.T21.41_03529	330214.NIDE0280	6.5e-105	386.7	Nitrospirae	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K06187	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	3J0KB@40117,COG0353@1,COG0353@2	NA|NA|NA	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MAG.T21.41_03530	330214.NIDE0281	1.1e-60	239.2	Nitrospirae	dksA			ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	3J0TH@40117,COG1734@1,COG1734@2	NA|NA|NA	T	Prokaryotic dksA/traR C4-type zinc finger
MAG.T21.41_03534	330214.NIDE0285	6.8e-69	266.5	Bacteria				ko:K07063					ko00000				Bacteria	COG1569@1,COG1569@2	NA|NA|NA	S	PIN domain
MAG.T21.41_03536	1283299.AUKG01000002_gene4029	3.3e-94	352.1	Actinobacteria			2.6.1.87	ko:K07806,ko:K21337	ko00520,ko00523,ko01130,ko01503,ko02020,map00520,map00523,map01130,map01503,map02020	M00721,M00761	R07659,R11467	RC00006,RC01514,RC03445	ko00000,ko00001,ko00002,ko01000,ko01005,ko01007				Bacteria	2GKD7@201174,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_03537	330214.NIDE2873	7.6e-78	297.4	Bacteria	wapR			ko:K12987,ko:K12988					ko00000,ko01000,ko01003,ko01005		GT2		Bacteria	COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_03542	1280944.HY17_19035	1.3e-101	378.6	Bacteria	tagX	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	COG0457@1,COG0457@2,COG1216@1,COG1216@2,COG2604@1,COG2604@2	NA|NA|NA	S	Protein of unknown function DUF115
MAG.T21.41_03544	330214.NIDE2435	1.2e-147	530.0	Bacteria													Bacteria	COG3746@1,COG3746@2	NA|NA|NA		
MAG.T21.41_03545	110319.CF8_3295	1.4e-34	153.3	Propionibacteriales													Bacteria	2GKFS@201174,4DNN6@85009,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T21.41_03546	330214.NIDE2438	4.9e-58	230.3	Nitrospirae				ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	3J0UW@40117,COG2905@1,COG2905@2	NA|NA|NA	T	Domain in cystathionine beta-synthase and other proteins.
MAG.T21.41_03547	330214.NIDE2439	1.5e-59	235.3	Nitrospirae	pal			ko:K03640					ko00000,ko02000	2.C.1.2			Bacteria	3J17Q@40117,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
MAG.T21.41_03548	330214.NIDE3823	4.5e-129	467.6	Bacteria	ddh		1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1748@1,COG1748@2	NA|NA|NA	E	saccharopine dehydrogenase activity
MAG.T21.41_03550	330214.NIDE3822	5.4e-67	260.4	Bacteria	ybcL			ko:K06910					ko00000				Bacteria	COG1881@1,COG1881@2	NA|NA|NA	S	positive regulation of acetylcholine metabolic process
MAG.T21.41_03551	330214.NIDE3819	1e-123	449.9	Bacteria				ko:K07282					ko00000				Bacteria	COG2843@1,COG2843@2	NA|NA|NA	M	Bacterial capsule synthesis protein PGA_cap
MAG.T21.41_03552	330214.NIDE3818	2.4e-48	198.4	Bacteria	soxX			ko:K02305,ko:K17223	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00529,M00595	R00294,R10151	RC02794,RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.10			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_03554	330214.NIDE3247	3.2e-52	211.8	Bacteria				ko:K02282					ko00000,ko02035,ko02044				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_03556	330214.NIDE2682	1.1e-122	446.0	Bacteria				ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111				ko00000,ko00001,ko02000	1.B.18			Bacteria	COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export
MAG.T21.41_03557	330214.NIDE2683	0.0	1205.3	Bacteria	capD	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	4.2.1.115,4.2.1.135,4.2.1.46	ko:K01710,ko:K15894,ko:K15912,ko:K19421	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R06513,R09697	RC00402,RC02609	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1086@1,COG1086@2	NA|NA|NA	GM	Polysaccharide biosynthesis protein
MAG.T21.41_03558	330214.NIDE2684	7.8e-35	153.3	Bacteria													Bacteria	COG1434@1,COG1434@2	NA|NA|NA	S	Gram-negative-bacterium-type cell wall biogenesis
MAG.T21.41_03559	330214.NIDE2685	3.6e-194	684.1	Nitrospirae	vioA	GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771	2.6.1.33	ko:K13308,ko:K20429	ko00523,ko01130,map00523,map01130	M00797	R02773	RC00006,RC00781	ko00000,ko00001,ko00002,ko01000				Bacteria	3J09X@40117,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T21.41_03560	330214.NIDE2686	2e-69	268.5	Bacteria													Bacteria	COG1853@1,COG1853@2	NA|NA|NA	S	FMN binding
MAG.T21.41_03561	330214.NIDE2687	3.5e-93	348.2	Bacteria													Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_03562	330214.NIDE2688	5.8e-98	363.6	Bacteria													Bacteria	COG2348@1,COG2348@2	NA|NA|NA	V	transferase activity, transferring amino-acyl groups
MAG.T21.41_03563	652103.Rpdx1_0596	5.4e-267	926.4	Bradyrhizobiaceae	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130		R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000			iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	Bacteria	1MU6Y@1224,2TSG6@28211,3JUJH@41294,COG0277@1,COG0277@2	NA|NA|NA	C	FAD linked oxidases, C-terminal domain
MAG.T21.41_03564	1121396.KB893064_gene1164	3.2e-57	229.6	Desulfobacterales				ko:K06871					ko00000				Bacteria	1PZXY@1224,2MK2Q@213118,2WMX1@28221,42RB6@68525,COG0641@1,COG0641@2	NA|NA|NA	C	4Fe-4S single cluster domain
MAG.T21.41_03566	330214.NIDE3759	4.1e-59	234.2	Bacteria				ko:K02348					ko00000				Bacteria	COG2153@1,COG2153@2	NA|NA|NA	K	protein acetylation
MAG.T21.41_03567	330214.NIDE3757	4.2e-142	510.8	Bacteria													Bacteria	COG0589@1,COG0589@2	NA|NA|NA	T	AMP binding
MAG.T21.41_03568	330214.NIDE3756	1.4e-152	545.8	Nitrospirae	cusB			ko:K15727					ko00000,ko02000	8.A.1.2.1			Bacteria	3J15V@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03571	330214.NIDE0447	3.4e-78	297.7	Nitrospirae	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71,4.2.3.4	ko:K00891,ko:K13829,ko:K15546	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000,ko03000			iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332	Bacteria	3J0R8@40117,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MAG.T21.41_03572	330214.NIDE0446	5.7e-147	526.9	Nitrospirae	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0SM@40117,COG0169@1,COG0169@2	NA|NA|NA	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MAG.T21.41_03573	1123252.ATZF01000001_gene1093	1.1e-53	216.9	Thermoactinomycetaceae													Bacteria	1TSCT@1239,27CWA@186824,4HD4Z@91061,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T21.41_03574	330214.NIDE0444	4e-156	557.4	Nitrospirae	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442					ko00000,ko01000,ko03016				Bacteria	3J0PT@40117,COG2519@1,COG2519@2	NA|NA|NA	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MAG.T21.41_03575	330214.NIDE0443	7.2e-191	673.3	Nitrospirae	rpoD			ko:K03086,ko:K03091					ko00000,ko03021				Bacteria	3J0E4@40117,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T21.41_03576	330214.NIDE0442	2.3e-161	575.1	Bacteria			3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T21.41_03578	330214.NIDE0440	1.8e-218	765.0	Bacteria	gdhA		1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	COG0334@1,COG0334@2	NA|NA|NA	E	glutamate dehydrogenase [NAD(P)+] activity
MAG.T21.41_03581	330214.NIDE0437	1.9e-62	245.4	Bacteria	glbN			ko:K06886					ko00000				Bacteria	COG2346@1,COG2346@2	NA|NA|NA	O	COG2346, Truncated hemoglobins
MAG.T21.41_03582	330214.NIDE0436	6e-143	513.8	Nitrospirae	cynR			ko:K11921					ko00000,ko03000				Bacteria	3J16P@40117,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_03584	330214.NIDE0434	2.3e-154	551.6	Nitrospirae	dacA		3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	3J179@40117,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
MAG.T21.41_03586	330214.NIDE0431	1e-85	323.9	Bacteria													Bacteria	COG3391@1,COG3391@2	NA|NA|NA	CO	amine dehydrogenase activity
MAG.T21.41_03589	330214.NIDE0429	2.8e-161	574.7	Bacteria													Bacteria	2C1IB@1,2ZG3S@2	NA|NA|NA	S	Proto-chlorophyllide reductase 57 kD subunit
MAG.T21.41_03590	330214.NIDE0428	1.8e-41	174.9	Nitrospirae	ihfB			ko:K05788					ko00000,ko03032,ko03036,ko03400				Bacteria	3J19J@40117,COG0776@1,COG0776@2	NA|NA|NA	L	bacterial (prokaryotic) histone like domain
MAG.T21.41_03591	330214.NIDE0427	1.9e-153	548.5	Nitrospirae	sppA			ko:K04773					ko00000,ko01000,ko01002				Bacteria	3J0J0@40117,COG0616@1,COG0616@2	NA|NA|NA	OU	Peptidase family S49
MAG.T21.41_03592	330214.NIDE0426	4.2e-292	1010.0	Nitrospirae	rpsA		1.17.7.4	ko:K02945,ko:K03527,ko:K07571	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011				Bacteria	3J0CA@40117,COG0539@1,COG0539@2,COG1185@1,COG1185@2	NA|NA|NA	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
MAG.T21.41_03593	1121949.AQXT01000002_gene1956	2.6e-284	984.2	Hyphomonadaceae			3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	1MU96@1224,2TS9I@28211,43YPN@69657,COG0610@1,COG0610@2	NA|NA|NA	V	Type I restriction enzyme R protein N terminus (HSDR_N)
MAG.T21.41_03594	190650.CC_2276	5.1e-39	167.5	Caulobacterales													Bacteria	1R3U2@1224,2KGCD@204458,2U3SX@28211,COG2850@1,COG2850@2	NA|NA|NA	S	peptidyl-arginine hydroxylation
MAG.T21.41_03595	237368.SCABRO_03848	1.3e-19	102.4	Planctomycetes	ttg2A			ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	2J2WI@203682,COG1127@1,COG1127@2	NA|NA|NA	Q	ABC transporter
MAG.T21.41_03596	237368.SCABRO_03847	1.1e-54	220.7	Bacteria	iamC			ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	COG1463@1,COG1463@2	NA|NA|NA	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAG.T21.41_03597	237368.SCABRO_03846	1e-41	176.8	Bacteria				ko:K18480		M00669			ko00000,ko00002,ko02000	3.A.1.27.1			Bacteria	COG3009@1,COG3009@2	NA|NA|NA	Q	Protein conserved in bacteria
MAG.T21.41_03598	330214.NIDE1691	2.5e-72	279.6	Nitrospirae													Bacteria	3J0RT@40117,COG0477@1,COG2814@2	NA|NA|NA	EGP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03599	1132855.KB913035_gene1532	9e-190	669.5	Betaproteobacteria													Bacteria	1NX2K@1224,2VI7H@28216,COG5368@1,COG5368@2	NA|NA|NA	S	Putative glucoamylase
MAG.T21.41_03601	1163409.UUA_03563	2.1e-09	67.8	Xanthomonadales	silP	GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	1MU08@1224,1RN2C@1236,1X3GA@135614,COG2217@1,COG2217@2	NA|NA|NA	P	Heavy metal translocating P-type atpase
MAG.T21.41_03602	1123508.JH636456_gene146	0.0	1119.0	Planctomycetes	pacS	GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	2IXAD@203682,COG2217@1,COG2217@2	NA|NA|NA	P	heavy metal translocating P-type ATPase
MAG.T21.41_03604	176299.Atu4836	1.6e-12	78.2	Rhizobiaceae	ppgK		2.7.1.2,2.7.1.63,5.3.1.9	ko:K00845,ko:K00886,ko:K01810	ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114,M00549	R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321	RC00002,RC00017,RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1NSQA@1224,2TSPZ@28211,4B9C4@82115,COG1940@1,COG1940@2	NA|NA|NA	GK	ROK family
MAG.T21.41_03605	1380394.JADL01000007_gene4558	1.1e-139	503.1	Alphaproteobacteria	gnd		1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2620,iNJ661.Rv1122	Bacteria	1QU14@1224,2TT6S@28211,COG1023@1,COG1023@2	NA|NA|NA	G	6-phosphogluconate dehydrogenase
MAG.T21.41_03606	1267535.KB906767_gene3855	5.9e-160	570.9	Acidobacteriia	zwf		1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2JKTN@204432,3Y627@57723,COG0364@1,COG0364@2	NA|NA|NA	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAG.T21.41_03607	392499.Swit_4012	1.1e-54	220.7	Sphingomonadales	prmA_2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736											Bacteria	1QZVV@1224,2KAK8@204457,2TYFE@28211,COG3897@1,COG3897@2	NA|NA|NA	S	Methyltransferase domain
MAG.T21.41_03608	698761.RTCIAT899_CH13105	9.1e-74	284.3	Alphaproteobacteria	metW	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249	2.1.1.255	ko:K15256,ko:K16217,ko:K21786	ko00333,ko01130,map00333,map01130	M00837,M00838	R11670		ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	1R1J1@1224,2TZ30@28211,COG4123@1,COG4123@2	NA|NA|NA	H	Methyltransferase FkbM domain
MAG.T21.41_03611	330214.NIDE2183	7.4e-155	554.7	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_03612	330214.NIDE2185	1.2e-47	197.2	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_03613	330214.NIDE2188	2.1e-25	122.5	Bacteria				ko:K03088,ko:K07165					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_03614	330214.NIDE2173	4e-17	94.0	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG4774@1,COG4774@2	NA|NA|NA	P	siderophore transport
MAG.T21.41_03615	472759.Nhal_1792	5.3e-169	601.7	Chromatiales	MA20_29525			ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1QTT0@1224,1RNBT@1236,1WXZV@135613,COG4773@1,COG4773@2	NA|NA|NA	P	TonB dependent receptor
MAG.T21.41_03616	330214.NIDE3525	2.7e-57	229.2	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_03617	330214.NIDE3526	2.7e-27	128.6	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_03618	1123020.AUIE01000037_gene4732	3.6e-155	554.7	Pseudomonas aeruginosa group	MA20_29520												Bacteria	1MXGY@1224,1RYZN@1236,1YD2H@136841,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_03619	228410.NE1097	6.6e-297	1026.5	Nitrosomonadales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1MV0X@1224,2WGH3@28216,374MA@32003,COG4774@1,COG4774@2	NA|NA|NA	P	TonB-dependent Receptor Plug Domain
MAG.T21.41_03620	330214.NIDE3525	5.2e-56	224.9	Bacteria				ko:K07165					ko00000				Bacteria	COG3712@1,COG3712@2	NA|NA|NA	PT	iron ion homeostasis
MAG.T21.41_03621	330214.NIDE3526	1.7e-29	136.0	Bacteria				ko:K03088					ko00000,ko03021				Bacteria	COG1595@1,COG1595@2	NA|NA|NA	K	DNA-templated transcription, initiation
MAG.T21.41_03622	330214.NIDE2083	6.4e-272	943.0	Nitrospirae	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711	Bacteria	3J1FS@40117,COG0033@1,COG0033@2	NA|NA|NA	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
MAG.T21.41_03623	330214.NIDE2082	3.7e-101	374.4	Bacteria													Bacteria	COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
MAG.T21.41_03628	330214.NIDE2074	2.7e-205	721.1	Bacteria	top6A		5.99.1.3	ko:K03166					ko00000,ko01000,ko03032				Bacteria	COG1697@1,COG1697@2	NA|NA|NA	L	DNA topoisomerase VI subunit A
MAG.T21.41_03629	330214.NIDE2073	0.0	1099.0	Bacteria	top6B		5.99.1.3	ko:K03167					ko00000,ko01000,ko03032				Bacteria	COG1389@1,COG1389@2	NA|NA|NA	L	DNA topoisomerase II activity
MAG.T21.41_03631	330214.NIDE2070	9.5e-85	320.1	Bacteria			3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021				Bacteria	COG0745@1,COG0745@2,COG2202@1,COG2202@2	NA|NA|NA	T	Pas domain
MAG.T21.41_03632	330214.NIDE2070	6.8e-106	390.6	Bacteria			3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021				Bacteria	COG0745@1,COG0745@2,COG2202@1,COG2202@2	NA|NA|NA	T	Pas domain
MAG.T21.41_03633	330214.NIDE2069	3.9e-20	103.2	Bacteria													Bacteria	33KP1@2,arCOG12353@1	NA|NA|NA		
MAG.T21.41_03634	1348657.M622_08980	3.1e-52	211.1	Rhodocyclales	wecB		5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1QUYI@1224,2KVGN@206389,2WFJ1@28216,COG0381@1,COG0381@2	NA|NA|NA	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MAG.T21.41_03636	335283.Neut_0179	7e-43	181.0	Nitrosomonadales	wbbL			ko:K07011					ko00000				Bacteria	1NG6M@1224,2VQVQ@28216,374K8@32003,COG1216@1,COG1216@2	NA|NA|NA	S	glycosyl transferase, family 2
MAG.T21.41_03637	338969.Rfer_1259	2.6e-80	305.8	Proteobacteria	wbbK	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576											Bacteria	1RASH@1224,COG0438@1,COG0438@2	NA|NA|NA	M	glucan biosynthetic process
MAG.T21.41_03638	1242969.ATCC51562_1161	2.1e-44	186.0	delta/epsilon subdivisions	wcaE	GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K13683					ko00000,ko01000,ko01003		GT2		Bacteria	1QVXC@1224,43BQT@68525,COG0463@1,COG0463@2	NA|NA|NA	M	PFAM Glycosyl transferase family 2
MAG.T21.41_03641	330214.NIDE2959	0.0	1238.8	Bacteria				ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_03642	330214.NIDE2960	2.4e-237	828.2	Bacteria													Bacteria	28H5N@1,2Z7I8@2	NA|NA|NA		
MAG.T21.41_03643	1173023.KE650771_gene1001	7.6e-31	139.8	Stigonemataceae													Bacteria	1GKII@1117,1JM9T@1189,COG3657@1,COG3657@2	NA|NA|NA	S	Phage derived protein Gp49-like (DUF891)
MAG.T21.41_03644	443143.GM18_2548	6e-24	116.7	delta/epsilon subdivisions													Bacteria	1N75D@1224,42V7U@68525,COG3636@1,COG3636@2	NA|NA|NA	K	Addiction module antidote protein
MAG.T21.41_03646	288000.BBta_4943	5.5e-33	148.3	Bradyrhizobiaceae				ko:K07451,ko:K07453					ko00000,ko01000,ko02048				Bacteria	1MZRA@1224,2U8HQ@28211,3K254@41294,COG3183@1,COG3183@2	NA|NA|NA	V	HNH nucleases
MAG.T21.41_03647	661478.OP10G_1892	1.9e-13	82.0	Bacteria													Bacteria	COG5606@1,COG5606@2	NA|NA|NA		
MAG.T21.41_03648	1034943.BN1094_00618	4.5e-31	140.6	Legionellales													Bacteria	1JEPD@118969,1MZC9@1224,1S8WB@1236,COG4679@1,COG4679@2	NA|NA|NA	S	Phage derived protein Gp49-like (DUF891)
MAG.T21.41_03649	330214.NIDE2963	3.9e-38	164.5	Nitrospirae													Bacteria	3J13N@40117,COG1846@1,COG1846@2	NA|NA|NA	K	helix_turn_helix multiple antibiotic resistance protein
MAG.T21.41_03650	671143.DAMO_1803	3.7e-18	98.2	Bacteria													Bacteria	2EAWU@1,334Y1@2	NA|NA|NA	S	Hemerythrin HHE cation binding domain
MAG.T21.41_03652	330214.NIDE2963	1.1e-80	306.2	Nitrospirae													Bacteria	3J13N@40117,COG1846@1,COG1846@2	NA|NA|NA	K	helix_turn_helix multiple antibiotic resistance protein
MAG.T21.41_03653	330214.NIDE2964	1e-178	632.9	Nitrospirae	mexE			ko:K18901,ko:K19586		M00698,M00767			ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.47,8.A.1			Bacteria	3J11U@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_03663	706587.Desti_0528	5.2e-33	149.4	Syntrophobacterales	recD2	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	2.7.7.7,3.1.11.5,6.5.1.2	ko:K01972,ko:K02342,ko:K02600,ko:K03581	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378,R00382	RC00005,RC02795	ko00000,ko00001,ko00002,ko01000,ko03009,ko03021,ko03032,ko03400				Bacteria	1MW43@1224,2MQAU@213462,2WJD6@28221,42M8J@68525,COG0272@1,COG0272@2,COG0507@1,COG0507@2	NA|NA|NA	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MAG.T21.41_03671	1158165.KB898873_gene378	7.6e-08	63.2	Proteobacteria	traL			ko:K12068					ko00000,ko02044	3.A.7.11.1			Bacteria	1NHEH@1224,2EJSV@1,33DHH@2	NA|NA|NA	S	TraL protein
MAG.T21.41_03672	1230343.CANP01000012_gene1089	1.2e-07	63.5	Legionellales	traE			ko:K12067					ko00000,ko02044	3.A.7.11.1			Bacteria	1JDX9@118969,1NC2W@1224,1SEQC@1236,2DPUP@1,333FI@2	NA|NA|NA	S	TraE protein
MAG.T21.41_03674	330214.NIDE0803	1.4e-159	568.9	Bacteria													Bacteria	COG0726@1,COG0726@2	NA|NA|NA	G	polysaccharide deacetylase
MAG.T21.41_03676	330214.NIDE0801	5.7e-99	367.1	Nitrospirae	ppiB		5.2.1.8	ko:K01802,ko:K03768					ko00000,ko01000,ko03110				Bacteria	3J18H@40117,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T21.41_03677	330214.NIDE0800	2.1e-102	378.6	Nitrospirae	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3,3.1.3.97	ko:K03685,ko:K07053	ko03008,ko05205,map03008,map05205		R00188,R11188	RC00078	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036				Bacteria	3J119@40117,COG0571@1,COG0571@2	NA|NA|NA	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MAG.T21.41_03678	330214.NIDE0799	2.4e-226	791.2	Nitrospirae	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Bacteria	3J0DH@40117,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MAG.T21.41_03679	330214.NIDE0798	7.6e-31	139.8	Nitrospirae	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509		ko:K02078					ko00000,ko00001				Bacteria	3J0RX@40117,COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAG.T21.41_03680	330214.NIDE0797	5e-123	447.2	Nitrospirae													Bacteria	3J0J6@40117,COG1028@1,COG1028@2	NA|NA|NA	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03681	330214.NIDE0796	3.8e-144	517.7	Nitrospirae	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004			iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598	Bacteria	3J0IX@40117,COG0331@1,COG0331@2	NA|NA|NA	I	Acyl transferase domain
MAG.T21.41_03682	330214.NIDE0795	1.4e-159	568.9	Nitrospirae	fabH		2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0FW@40117,COG0332@1,COG0332@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAG.T21.41_03683	330214.NIDE0794	2.1e-180	638.3	Nitrospirae	plsX		1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15	ko:K03621,ko:K21576,ko:K21577	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0DY@40117,COG0416@1,COG0416@2	NA|NA|NA	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MAG.T21.41_03684	500633.CLOHIR_01133	1.7e-11	74.7	Clostridia	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904		ko:K02911	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	1VEFI@1239,24QM0@186801,COG0333@1,COG0333@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL32 family
MAG.T21.41_03685	330214.NIDE0792	1.3e-76	292.7	Nitrospirae	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464		ko:K07040					ko00000				Bacteria	3J0UQ@40117,COG1399@1,COG1399@2	NA|NA|NA	S	Uncharacterized ACR, COG1399
MAG.T21.41_03686	1121396.KB893079_gene809	1.1e-18	99.0	Desulfobacterales	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02963	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ8U@1224,2MKM0@213118,2WR7Z@28221,42VJQ@68525,COG0238@1,COG0238@2	NA|NA|NA	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MAG.T21.41_03687	330214.NIDE0790	3e-66	257.7	Nitrospirae	ssb			ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	3J0NB@40117,COG0629@1,COG0629@2	NA|NA|NA	L	Single-strand binding protein family
MAG.T21.41_03688	330214.NIDE0789	4.2e-51	207.2	Nitrospirae	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	4.3.1.19	ko:K01754,ko:K02990	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010	M00178,M00570	R00220,R00996	RC00418,RC02600	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029				Bacteria	3J0VS@40117,COG0360@1,COG0360@2	NA|NA|NA	J	Binds together with S18 to 16S ribosomal RNA
MAG.T21.41_03690	330214.NIDE1770	1.3e-298	1032.7	Nitrospirae				ko:K09822					ko00000				Bacteria	3J0VY@40117,COG3002@1,COG3002@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2309)
MAG.T21.41_03691	330214.NIDE0600	7.9e-195	686.4	Nitrospirae	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659		ko:K06212,ko:K06402					ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3			Bacteria	3J0VG@40117,COG0517@1,COG0517@2,COG1994@1,COG1994@2	NA|NA|NA	S	Belongs to the peptidase M50B family
MAG.T21.41_03692	330214.NIDE0599	9.6e-105	386.3	Bacteria													Bacteria	COG0726@1,COG0726@2	NA|NA|NA	G	polysaccharide deacetylase
MAG.T21.41_03693	330214.NIDE0598	5.1e-68	263.8	Bacteria			3.5.1.104	ko:K22278					ko00000,ko01000				Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_03694	330214.NIDE0597	5.3e-63	246.9	Nitrospirae	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615	4.4.1.5	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	M00491	R02530	RC00004,RC00740	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.16,3.A.1.1.2		iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044	Bacteria	3J15P@40117,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase-like domain
MAG.T21.41_03695	330214.NIDE0596	9.2e-153	546.2	Nitrospirae	dapF		5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0JV@40117,COG0253@1,COG0253@2	NA|NA|NA	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MAG.T21.41_03696	330214.NIDE0595	1.2e-308	1065.1	Nitrospirae	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03703	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	3J0F1@40117,COG0322@1,COG0322@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MAG.T21.41_03701	330214.NIDE0590	3.3e-175	620.9	Bacteria			1.4.3.21	ko:K00276	ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110		R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740	RC00062,RC00189,RC00676,RC01052	ko00000,ko00001,ko01000				Bacteria	COG3733@1,COG3733@2	NA|NA|NA	Q	amine oxidase
MAG.T21.41_03702	330214.NIDE0589	8.5e-137	493.0	Nitrospirae	sdiA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K07782,ko:K15852,ko:K18098,ko:K18304,ko:K19666,ko:K19731,ko:K19733,ko:K19734,ko:K20334,ko:K20540	ko02020,ko02024,ko02025,ko02026,map02020,map02024,map02025,map02026	M00644,M00769			ko00000,ko00001,ko00002,ko01504,ko03000				Bacteria	3J1CH@40117,COG2197@1,COG2197@2	NA|NA|NA	K	Autoinducer binding domain
MAG.T21.41_03703	330214.NIDE0588	6.8e-221	773.1	Bacteria													Bacteria	2Z87F@2,arCOG06766@1	NA|NA|NA		
MAG.T21.41_03704	330214.NIDE0587	1.9e-234	818.1	Nitrospirae			2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0DH@40117,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MAG.T21.41_03705	330214.NIDE0586	3.9e-103	380.9	Bacteria													Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T21.41_03709	1454004.AW11_02002	3.9e-08	65.5	Betaproteobacteria													Bacteria	1NM6K@1224,2CEHR@1,2W6D5@28216,33D10@2	NA|NA|NA		
MAG.T21.41_03710	330214.NIDE0827	2.5e-242	844.3	Nitrospirae	forA		1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J105@40117,COG0674@1,COG0674@2	NA|NA|NA	C	Pyruvate:ferredoxin oxidoreductase core domain II
MAG.T21.41_03711	330214.NIDE0826	3.6e-134	484.2	Nitrospirae	porD			ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	3J0YH@40117,COG0226@1,COG0226@2	NA|NA|NA	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03712	330214.NIDE0825	7.3e-55	219.5	Nitrospirae	porE		1.2.7.1	ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J1A9@40117,COG1144@1,COG1144@2	NA|NA|NA	C	Oxidoreductase
MAG.T21.41_03713	330214.NIDE0824	9.4e-119	433.0	Nitrospirae			1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0YE@40117,COG1014@1,COG1014@2	NA|NA|NA	C	Pyruvate ferredoxin/flavodoxin oxidoreductase
MAG.T21.41_03714	330214.NIDE0823	3.6e-152	544.3	Nitrospirae	forB		1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J10F@40117,COG1013@1,COG1013@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_03715	247639.MGP2080_08801	5.7e-07	60.1	Gammaproteobacteria			1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000				Bacteria	1RHDY@1224,1T0DC@1236,COG0685@1,COG0685@2	NA|NA|NA	E	Methylene-tetrahydrofolate reductase C terminal
MAG.T21.41_03716	330214.NIDE0820	4.8e-63	247.3	Nitrospirae	queF		1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100		R07605	RC01875	ko00000,ko00001,ko01000,ko03016				Bacteria	3J0R4@40117,COG0780@1,COG0780@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MAG.T21.41_03718	330214.NIDE0819	9.7e-161	573.2	Bacteria	omp12			ko:K12976,ko:K22110					ko00000,ko01000,ko01005,ko02000	1.B.35.1,1.B.35.2			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_03719	330214.NIDE2066	5.9e-82	310.5	Bacteria													Bacteria	2B047@1,31SEM@2	NA|NA|NA		
MAG.T21.41_03720	330214.NIDE2065	1.3e-61	242.3	Bacteria													Bacteria	2B047@1,31SEM@2	NA|NA|NA		
MAG.T21.41_03721	330214.NIDE2064	1e-80	306.2	Bacteria													Bacteria	2ATAH@1,31ITJ@2	NA|NA|NA		
MAG.T21.41_03722	330214.NIDE2063	3.1e-63	247.7	Bacteria	osmE	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896		ko:K04064,ko:K06186					ko00000,ko02000	1.B.33.1			Bacteria	COG2913@1,COG2913@2	NA|NA|NA	J	Gram-negative-bacterium-type cell outer membrane assembly
MAG.T21.41_03723	330214.NIDE2061	6.1e-72	276.9	Bacteria				ko:K07226					ko00000				Bacteria	COG0748@1,COG0748@2	NA|NA|NA	P	coenzyme F420 binding
MAG.T21.41_03729	330214.NIDE2055	3.7e-280	970.3	Nitrospirae	lnt			ko:K03820					ko00000,ko01000		GT2		Bacteria	3J0HA@40117,COG0815@1,COG0815@2	NA|NA|NA	M	Carbon-nitrogen hydrolase
MAG.T21.41_03730	330214.NIDE2054	5.3e-201	706.8	Nitrospirae	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02836					ko00000,ko03012				Bacteria	3J0EX@40117,COG1186@1,COG1186@2	NA|NA|NA	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MAG.T21.41_03731	330214.NIDE2053	2.3e-268	931.0	Nitrospirae	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	Bacteria	3J0AW@40117,COG1190@1,COG1190@2	NA|NA|NA	J	tRNA synthetases class II (D, K and N)
MAG.T21.41_03732	330214.NIDE2052	7e-218	763.1	Nitrospirae	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778		ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125			Bacteria	3J0EF@40117,COG4591@1,COG4591@2	NA|NA|NA	M	MacB-like periplasmic core domain
MAG.T21.41_03733	330214.NIDE2051	2.5e-113	414.8	Nitrospirae	lolD			ko:K09810	ko02010,map02010	M00255			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125			Bacteria	3J0IT@40117,COG1136@1,COG1136@2	NA|NA|NA	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner
MAG.T21.41_03734	330214.NIDE2050	9.8e-195	686.0	Bacteria													Bacteria	COG2067@1,COG2067@2	NA|NA|NA	I	long-chain fatty acid transporting porin activity
MAG.T21.41_03735	330214.NIDE2049	3.6e-95	354.4	Bacteria													Bacteria	2FJ9R@1,34AZR@2	NA|NA|NA		
MAG.T21.41_03736	330214.NIDE2048	3.2e-139	501.5	Bacteria													Bacteria	COG2203@1,COG2203@2	NA|NA|NA	T	Gaf domain
MAG.T21.41_03737	330214.NIDE2047	6.5e-129	466.8	Nitrospirae	trpA		4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0ME@40117,COG0159@1,COG0159@2	NA|NA|NA	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MAG.T21.41_03738	330214.NIDE2046	7.5e-214	749.6	Nitrospirae	trpB		4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0E1@40117,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MAG.T21.41_03739	330214.NIDE2045	9.7e-99	366.3	Nitrospirae	trpF	GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24	ko:K01696,ko:K01817,ko:K13498,ko:K22100	ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230	M00023,M00840	R00674,R02340,R02722,R03508,R03509,R11072	RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343	ko00000,ko00001,ko00002,ko01000			iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330	Bacteria	3J0SA@40117,COG0135@1,COG0135@2	NA|NA|NA	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase
MAG.T21.41_03741	330214.NIDE2043	4.1e-134	484.2	Nitrospirae	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2494,iJN746.PP_0422	Bacteria	3J0NT@40117,COG0134@1,COG0134@2	NA|NA|NA	E	Indole-3-glycerol phosphate synthase
MAG.T21.41_03742	330214.NIDE2042	1.8e-168	598.6	Nitrospirae	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2495	Bacteria	3J0HE@40117,COG0547@1,COG0547@2	NA|NA|NA	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MAG.T21.41_03743	330214.NIDE2041	1.9e-39	167.9	Nitrospirae	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.4.2.18,2.6.1.85,4.1.3.27	ko:K01658,ko:K01664,ko:K13497	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01073,R01716	RC00010,RC00440,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2496	Bacteria	3J0H8@40117,COG0512@1,COG0512@2	NA|NA|NA	EH	Peptidase C26
MAG.T21.41_03746	330214.NIDE2364	3.1e-75	287.7	Nitrospirae				ko:K08976					ko00000				Bacteria	3J1D2@40117,COG2322@1,COG2322@2	NA|NA|NA	S	Protein of unknown function (DUF420)
MAG.T21.41_03747	330214.NIDE2363	4.1e-72	277.7	Bacteria	bdlA			ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	COG0840@1,COG0840@2,COG1017@1,COG1017@2,COG2202@1,COG2202@2	NA|NA|NA	C	nitric oxide dioxygenase activity
MAG.T21.41_03749	680646.RMDY18_15470	1.4e-14	87.0	Micrococcaceae													Bacteria	1WC72@1268,2EJ0Q@1,2GUPE@201174,33CRW@2	NA|NA|NA		
MAG.T21.41_03751	330214.NIDE1207	8.2e-127	459.9	Bacteria	pstS			ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	COG0226@1,COG0226@2	NA|NA|NA	P	phosphate ion binding
MAG.T21.41_03752	330214.NIDE1208	4.9e-48	196.8	Bacteria													Bacteria	COG2331@1,COG2331@2	NA|NA|NA	P	Regulatory protein, FmdB family
MAG.T21.41_03755	330214.NIDE0001	1.2e-39	168.7	Nitrospirae	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112		ko:K02313	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Bacteria	3J0FQ@40117,COG0593@1,COG0593@2	NA|NA|NA	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MAG.T21.41_03756	330214.NIDE0002	1.6e-197	695.3	Nitrospirae	dnaN		2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	3J0RU@40117,COG0592@1,COG0592@2	NA|NA|NA	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MAG.T21.41_03757	330214.NIDE0003	0.0	1544.6	Nitrospirae	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	3J0BB@40117,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T21.41_03758	330214.NIDE0004	0.0	1546.2	Nitrospirae	gyrA		5.99.1.3	ko:K02469					ko00000,ko01000,ko03032,ko03400				Bacteria	3J0EH@40117,COG0188@1,COG0188@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T21.41_03760	330214.NIDE0006	1.6e-56	225.7	Bacteria													Bacteria	COG5512@1,COG5512@2	NA|NA|NA	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MAG.T21.41_03761	330214.NIDE0007	2.4e-78	298.1	Nitrospirae	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03664					ko00000				Bacteria	3J0Q4@40117,COG0691@1,COG0691@2	NA|NA|NA	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MAG.T21.41_03762	330214.NIDE0009	5.9e-120	437.2	Bacteria													Bacteria	COG0702@1,COG0702@2	NA|NA|NA	GM	epimerase
MAG.T21.41_03763	330214.NIDE2085	3.6e-289	1000.7	Bacteria	addB		3.6.4.12	ko:K16899					ko00000,ko01000,ko03400				Bacteria	COG3857@1,COG3857@2	NA|NA|NA	L	exonuclease activity
MAG.T21.41_03765	1144275.COCOR_02852	3.3e-82	312.4	Proteobacteria													Bacteria	1RCEH@1224,2CH7C@1,32S5G@2	NA|NA|NA		
MAG.T21.41_03766	330214.NIDE0805	0.0	1765.7	Nitrospirae			2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J0ZF@40117,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2203@1,COG2203@2,COG5002@1,COG5002@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03767	330214.NIDE0806	1.5e-166	592.4	Bacteria													Bacteria	COG3287@1,COG3287@2	NA|NA|NA	M	FIST C domain
MAG.T21.41_03769	330214.NIDE0808	9.1e-127	459.5	Bacteria													Bacteria	2EGFY@1,33A7X@2	NA|NA|NA		
MAG.T21.41_03770	330214.NIDE0809	2e-159	568.5	Bacteria													Bacteria	COG2706@1,COG2706@2	NA|NA|NA	G	6-phosphogluconolactonase activity
MAG.T21.41_03771	330214.NIDE0810	1.3e-138	499.2	Nitrospirae	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1162	Bacteria	3J0FT@40117,COG0190@1,COG0190@2	NA|NA|NA	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MAG.T21.41_03772	330214.NIDE0811	1.1e-161	575.9	Nitrospirae	metF		1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0I8@40117,COG0685@1,COG0685@2	NA|NA|NA	C	Methylenetetrahydrofolate reductase
MAG.T21.41_03773	330214.NIDE0812	3.1e-123	448.0	Nitrospirae	panB		2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0GX@40117,COG0413@1,COG0413@2	NA|NA|NA	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MAG.T21.41_03774	330214.NIDE0813	8.2e-31	139.8	Bacteria				ko:K09763					ko00000				Bacteria	COG1547@1,COG1547@2	NA|NA|NA	S	Domain of unknown function (DUF309)
MAG.T21.41_03775	330214.NIDE0814	2.9e-119	434.9	Bacteria	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230		R00125	RC00002	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074	Bacteria	COG0639@1,COG0639@2	NA|NA|NA	T	phosphoprotein phosphatase activity
MAG.T21.41_03776	330214.NIDE0815	0.0	1080.5	Nitrospirae													Bacteria	3J0ZF@40117,COG0642@1,COG0642@2,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2203@1,COG2203@2,COG3829@1,COG3829@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03777	330214.NIDE0816	0.0	1148.3	Nitrospirae													Bacteria	3J0ZF@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG5002@1,COG5002@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03778	330214.NIDE0817	7.6e-25	119.4	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_03779	330214.NIDE0817	4.8e-39	167.9	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_03780	330214.NIDE0818	5.3e-92	344.0	Bacteria	moxG			ko:K00406,ko:K16255	ko00190,ko00680,ko01100,ko01120,ko02020,map00190,map00680,map01100,map01120,map02020	M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_03781	330214.NIDE0832	3.3e-16	90.1	Bacteria													Bacteria	COG2453@1,COG2453@2	NA|NA|NA	T	phosphatase
MAG.T21.41_03784	330214.NIDE0829	6.9e-122	444.1	Nitrospirae													Bacteria	3J16W@40117,COG5459@1,COG5459@2	NA|NA|NA	J	Mitochondrial small ribosomal subunit Rsm22
MAG.T21.41_03788	330214.NIDE2823	1.3e-95	355.9	Bacteria	pilN			ko:K02461,ko:K02662,ko:K02663,ko:K12289	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15			Bacteria	COG3166@1,COG3166@2	NA|NA|NA	NU	PFAM Fimbrial assembly family protein
MAG.T21.41_03789	330214.NIDE2824	6e-164	583.6	Bacteria				ko:K02662					ko00000,ko02035,ko02044				Bacteria	COG4972@1,COG4972@2	NA|NA|NA	NU	Pilus assembly protein
MAG.T21.41_03790	330214.NIDE2825	0.0	1078.5	Nitrospirae	gspE			ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	3J0XR@40117,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II/IV secretion system protein
MAG.T21.41_03791	330214.NIDE2826	1.2e-206	725.7	Nitrospirae	pilC			ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	3J0HZ@40117,COG1459@1,COG1459@2	NA|NA|NA	U	Type II secretion system (T2SS), protein F
MAG.T21.41_03792	330214.NIDE2827	5.5e-25	121.7	Bacteria													Bacteria	COG1388@1,COG1388@2,COG3170@1,COG3170@2	NA|NA|NA	NU	translation initiation factor activity
MAG.T21.41_03793	330214.NIDE2828	7.8e-62	243.0	Bacteria	oxpG			ko:K02456	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
MAG.T21.41_03794	479434.Sthe_3030	3.8e-55	222.6	Thermomicrobia	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0166,iSB619.SA_RS08370	Bacteria	27Y4Y@189775,2G64M@200795,COG0285@1,COG0285@2	NA|NA|NA	H	Mur ligase family, glutamate ligase domain
MAG.T21.41_03795	1162668.LFE_0769	2.5e-162	578.2	Nitrospirae	icd		1.1.1.41,1.1.1.42	ko:K00030,ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R00709,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0X4@40117,COG0473@1,COG0473@2	NA|NA|NA	C	Isocitrate/isopropylmalate dehydrogenase
MAG.T21.41_03796	1162668.LFE_0770	1.1e-35	156.0	Bacteria			1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0473@1,COG0473@2	NA|NA|NA	CE	3-isopropylmalate dehydrogenase activity
MAG.T21.41_03797	330214.NIDE1724	1.8e-301	1041.2	Bacteria													Bacteria	COG5184@1,COG5184@2	NA|NA|NA	DZ	guanyl-nucleotide exchange factor activity
MAG.T21.41_03798	330214.NIDE1723	1.8e-70	271.9	Nitrospirae													Bacteria	3J144@40117,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
MAG.T21.41_03801	330214.NIDE1721	4.8e-22	110.5	Bacteria													Bacteria	2EU10@1,33MI2@2	NA|NA|NA		
MAG.T21.41_03803	330214.NIDE1711	9.6e-190	669.5	Bacteria	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230		R01057,R02749	RC00408	ko00000,ko00001,ko01000			iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Bacteria	COG1015@1,COG1015@2	NA|NA|NA	G	phosphopentomutase activity
MAG.T21.41_03804	330214.NIDE1710	6.7e-106	390.2	Bacteria	deoC		4.1.2.4	ko:K01619	ko00030,map00030		R01066	RC00436,RC00437	ko00000,ko00001,ko01000				Bacteria	COG0274@1,COG0274@2	NA|NA|NA	F	deoxyribose-phosphate aldolase activity
MAG.T21.41_03805	1382230.ASAP_3192	1.4e-101	376.7	Rhodospirillales													Bacteria	1MUE0@1224,2JX65@204441,2U5YT@28211,COG3950@1,COG3950@2	NA|NA|NA	S	AAA ATPase domain
MAG.T21.41_03806	1185876.BN8_00108	2.4e-52	212.6	Cytophagia													Bacteria	47SH4@768503,4NTZE@976,COG1403@1,COG1403@2	NA|NA|NA	V	HNH nucleases
MAG.T21.41_03807	272943.RSP_2045	2.2e-271	941.0	Alphaproteobacteria													Bacteria	1QUDB@1224,2TWRT@28211,COG1310@1,COG1310@2	NA|NA|NA	S	metal-dependent protease of the Pad1 Jab1 superfamily
MAG.T21.41_03808	272943.RSP_2046	3.8e-221	773.9	Alphaproteobacteria													Bacteria	1RFCM@1224,2UH01@28211,COG1746@1,COG1746@2	NA|NA|NA	J	tRNA cytidylyltransferase activity
MAG.T21.41_03809	272943.RSP_2047	0.0	1112.4	Alphaproteobacteria	thiF		2.7.7.80	ko:K21029	ko04122,map04122		R07459	RC00043	ko00000,ko00001,ko01000				Bacteria	1R3PX@1224,2UN61@28211,COG0476@1,COG0476@2	NA|NA|NA	H	ThiF family
MAG.T21.41_03810	272943.RSP_2048	4.6e-77	293.9	Proteobacteria													Bacteria	1NFWF@1224,COG1310@1,COG1310@2	NA|NA|NA	S	Prokaryotic homologs of the JAB domain
MAG.T21.41_03811	290340.AAur_1502	7.9e-09	68.2	Micrococcaceae													Bacteria	1W9DY@1268,2IQ64@201174,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase family M23
MAG.T21.41_03812	1437824.BN940_06111	8.1e-112	410.2	Alcaligenaceae													Bacteria	1MXI5@1224,2VKGF@28216,3T2K4@506,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_03813	391624.OIHEL45_17586	3.8e-77	295.0	Alphaproteobacteria				ko:K07506					ko00000,ko03000				Bacteria	1MXZQ@1224,2U0GT@28211,COG4977@1,COG4977@2	NA|NA|NA	K	helix_turn_helix, arabinose operon control protein
MAG.T21.41_03814	1479237.JMLY01000001_gene1801	1.6e-21	109.0	Alteromonadaceae	qbdB2												Bacteria	1R58D@1224,1RYZE@1236,46AQ7@72275,COG4313@1,COG4313@2	NA|NA|NA	C	Putative MetA-pathway of phenol degradation
MAG.T21.41_03817	257310.BB4743	2.4e-43	183.0	Proteobacteria				ko:K07165					ko00000				Bacteria	1RHW4@1224,COG3712@1,COG3712@2	NA|NA|NA	PT	FecR protein
MAG.T21.41_03818	1279017.AQYJ01000022_gene2725	3.6e-24	118.2	Alteromonadaceae	fecI12		5.2.1.8	ko:K03088,ko:K03769					ko00000,ko01000,ko03021,ko03110				Bacteria	1N6SV@1224,1SYWE@1236,468CK@72275,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma-70, region 4
MAG.T21.41_03819	330214.NIDE2171	9.4e-15	86.3	Bacteria				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	COG1629@1,COG1629@2	NA|NA|NA	P	transport
MAG.T21.41_03820	1121937.AUHJ01000032_gene3076	0.0	1091.6	Alteromonadaceae	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02355					ko00000,ko03012,ko03029				Bacteria	1MUCV@1224,1RNSZ@1236,4648C@72275,COG0480@1,COG0480@2	NA|NA|NA	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MAG.T21.41_03821	330214.NIDE0471	2.4e-132	478.4	Bacteria	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.1.15,6.3.4.19	ko:K04075,ko:K14058,ko:K21947			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Bacteria	COG0037@1,COG0037@2	NA|NA|NA	D	tRNA processing
MAG.T21.41_03824	330214.NIDE0469	3.4e-81	307.8	Nitrospirae	msrA		1.8.4.11	ko:K07304					ko00000,ko01000				Bacteria	3J12A@40117,COG0225@1,COG0225@2	NA|NA|NA	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAG.T21.41_03825	330214.NIDE0468	3e-276	957.2	Nitrospirae	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0XD@40117,COG0364@1,COG0364@2	NA|NA|NA	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAG.T21.41_03826	330214.NIDE0467	5.1e-84	317.8	Bacteria				ko:K03832					ko00000,ko02000	2.C.1.1			Bacteria	COG0810@1,COG0810@2	NA|NA|NA	M	energy transducer activity
MAG.T21.41_03830	330214.NIDE0462	1.9e-253	881.3	Bacteria													Bacteria	COG4949@1,COG4949@2	NA|NA|NA	S	Protein of unknown function (DUF3422)
MAG.T21.41_03832	330214.NIDE0460	1.8e-101	375.6	Nitrospirae	pal			ko:K03640					ko00000,ko02000	2.C.1.2			Bacteria	3J17Q@40117,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
MAG.T21.41_03834	330214.NIDE0457	4.4e-39	166.8	Bacteria	relB1			ko:K07473					ko00000,ko02048				Bacteria	COG3077@1,COG3077@2	NA|NA|NA	L	bacterial-type proximal promoter sequence-specific DNA binding
MAG.T21.41_03837	203122.Sde_0436	1.8e-13	83.2	Proteobacteria													Bacteria	1N7ZA@1224,2EDJI@1,337FD@2	NA|NA|NA		
MAG.T21.41_03838	1144275.COCOR_02854	5.3e-181	641.7	Myxococcales													Bacteria	1NEK3@1224,2WY5F@28221,2YW00@29,4327R@68525,COG4385@1,COG4385@2	NA|NA|NA	S	Phage tail protein (Tail_P2_I)
MAG.T21.41_03839	330214.NIDE4016	2.3e-243	847.8	Bacteria	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECIAI39_1322.ECIAI39_0637	Bacteria	COG0008@1,COG0008@2	NA|NA|NA	J	glutamate-tRNA ligase activity
MAG.T21.41_03841	330214.NIDE4018	1.5e-290	1005.0	Bacteria				ko:K15738					ko00000,ko02000	3.A.1.120.6			Bacteria	COG0488@1,COG0488@2	NA|NA|NA	L	(ABC) transporter
MAG.T21.41_03844	386456.JQKN01000006_gene1241	3.3e-80	305.8	Euryarchaeota				ko:K07126					ko00000				Archaea	2Y5SU@28890,COG1479@1,arCOG05223@2157	NA|NA|NA	S	Protein of unknown function DUF262
MAG.T21.41_03845	330214.NIDE0854	1.9e-71	275.4	Nitrospirae	fabH		2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0FW@40117,COG0332@1,COG0332@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAG.T21.41_03846	330214.NIDE0855	2.3e-89	335.1	Bacteria	MA20_27875			ko:K02039,ko:K07220					ko00000				Bacteria	COG1392@1,COG1392@2	NA|NA|NA	P	Protein of unknown function DUF47
MAG.T21.41_03847	330214.NIDE0856	1.7e-150	538.9	Nitrospirae	pit			ko:K03306					ko00000	2.A.20			Bacteria	3J1D1@40117,COG0306@1,COG0306@2	NA|NA|NA	P	Phosphate transporter family
MAG.T21.41_03848	330214.NIDE0857	6.7e-294	1016.1	Nitrospirae	phoR		2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J0I0@40117,COG5002@1,COG5002@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_03849	330214.NIDE0858	3.7e-123	447.6	Nitrospirae													Bacteria	3J0JU@40117,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
MAG.T21.41_03850	330214.NIDE0859	1.1e-173	615.9	Nitrospirae	ispH		1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011			iIT341.HP0400,iLJ478.TM1444	Bacteria	3J0PP@40117,COG0761@1,COG0761@2	NA|NA|NA	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MAG.T21.41_03851	330214.NIDE0860	0.0	1862.0	Nitrospirae	smc			ko:K03529					ko00000,ko03036				Bacteria	3J0W4@40117,COG1196@1,COG1196@2	NA|NA|NA	D	Required for chromosome condensation and partitioning
MAG.T21.41_03852	330214.NIDE0861	0.0	1326.2	Nitrospirae	shc		4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110		R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000				Bacteria	3J0ZD@40117,COG1657@1,COG1657@2	NA|NA|NA	I	Squalene-hopene cyclase C-terminal domain
MAG.T21.41_03853	330214.NIDE0862	2.9e-94	351.7	Bacteria	MA20_16045		1.17.7.4,3.2.2.9	ko:K01243,ko:K03527	ko00270,ko00900,ko01100,ko01110,ko01130,ko01230,map00270,map00900,map01100,map01110,map01130,map01230	M00034,M00096,M00609	R00194,R01401,R05884,R08210	RC00063,RC00318,RC01137,RC01487	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0775@1,COG0775@2	NA|NA|NA	F	adenosylhomocysteine nucleosidase activity
MAG.T21.41_03854	330214.NIDE0863	9.7e-130	469.5	Nitrospirae	mlaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J0I7@40117,COG0767@1,COG0767@2	NA|NA|NA	Q	Permease MlaE
MAG.T21.41_03855	330214.NIDE0864	6.7e-123	446.8	Nitrospirae	metN			ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J0J2@40117,COG1127@1,COG1127@2	NA|NA|NA	Q	ABC transporter
MAG.T21.41_03856	330214.NIDE0865	4.2e-69	267.3	Nitrospirae				ko:K02067	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	3J191@40117,COG1463@1,COG1463@2	NA|NA|NA	Q	MlaD protein
MAG.T21.41_03857	330214.NIDE0866	2.3e-94	351.7	Nitrospirae				ko:K07323	ko02010,map02010	M00210			ko00000,ko00001,ko00002,ko02000	3.A.1.27.3			Bacteria	3J13Z@40117,COG2854@1,COG2854@2	NA|NA|NA	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03858	330214.NIDE0867	8.7e-210	736.1	Nitrospirae													Bacteria	3J10P@40117,COG4775@1,COG4775@2	NA|NA|NA	M	Surface antigen
MAG.T21.41_03859	330214.NIDE0868	1.4e-157	562.4	Bacteria													Bacteria	COG2067@1,COG2067@2	NA|NA|NA	I	long-chain fatty acid transporting porin activity
MAG.T21.41_03860	330214.NIDE0869	0.0	1239.2	Nitrospirae	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	Bacteria	3J0WE@40117,COG1154@1,COG1154@2	NA|NA|NA	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MAG.T21.41_03861	330214.NIDE0870	1.3e-210	738.8	Nitrospirae	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000			iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037	Bacteria	3J0EA@40117,COG0821@1,COG0821@2	NA|NA|NA	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MAG.T21.41_03866	330214.NIDE2743	2.7e-182	644.8	Nitrospirae	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K01719,ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS15755,iYO844.BSU15610	Bacteria	3J0B6@40117,COG0007@1,COG0007@2,COG1587@1,COG1587@2	NA|NA|NA	H	Belongs to the precorrin methyltransferase family
MAG.T21.41_03867	330214.NIDE2742	8.8e-63	246.1	Bacteria	opuCA		2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12			Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_03868	330214.NIDE2741	1.8e-168	598.6	Nitrospirae	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147			iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	Bacteria	3J0DV@40117,COG0113@1,COG0113@2	NA|NA|NA	H	Delta-aminolevulinic acid dehydratase
MAG.T21.41_03869	330214.NIDE2740	2.7e-145	521.5	Nitrospirae	ribF		2.7.1.26,2.7.7.2	ko:K07011,ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS06310	Bacteria	3J0KY@40117,COG0196@1,COG0196@2	NA|NA|NA	H	Riboflavin kinase
MAG.T21.41_03870	330214.NIDE2739	4.8e-157	561.2	Nitrospirae	tilS		2.8.1.15,6.3.4.19	ko:K04075,ko:K14058,ko:K21947			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Bacteria	3J0SX@40117,COG0037@1,COG0037@2	NA|NA|NA	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MAG.T21.41_03871	330214.NIDE2738	9.8e-92	342.8	Nitrospirae	hpt		2.4.2.8,2.7.4.3	ko:K00760,ko:K00939	ko00230,ko00730,ko00983,ko01100,ko01110,ko01130,map00230,map00730,map00983,map01100,map01110,map01130	M00049	R00127,R00190,R01132,R01229,R01547,R02142,R08237,R08238,R08245,R11319	RC00002,RC00063,RC00122	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J0NZ@40117,COG0634@1,COG0634@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T21.41_03872	330214.NIDE2737	0.0	1169.5	Nitrospirae	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K03798		M00742			ko00000,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0AG@40117,COG0465@1,COG0465@2	NA|NA|NA	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAG.T21.41_03873	330214.NIDE2736	5.1e-113	414.1	Nitrospirae	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0NS@40117,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAG.T21.41_03874	330214.NIDE2735	1e-243	849.0	Nitrospirae	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130		R02060	RC00408	ko00000,ko00001,ko01000			iAF987.Gmet_1886,iSBO_1134.SBO_3206	Bacteria	3J0E7@40117,COG1109@1,COG1109@2	NA|NA|NA	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAG.T21.41_03875	330214.NIDE2734	0.0	1168.7	Nitrospirae				ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	3J0VB@40117,COG0658@1,COG0658@2,COG2333@1,COG2333@2	NA|NA|NA	S	Competence protein
MAG.T21.41_03877	1232683.ADIMK_0861	6.2e-59	233.8	Alteromonadaceae	adk		2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1RCIS@1224,1S692@1236,467RY@72275,COG0563@1,COG0563@2	NA|NA|NA	F	COG0563 Adenylate kinase and related kinases
MAG.T21.41_03878	234267.Acid_3700	4.3e-105	388.3	Bacteria													Bacteria	28HDU@1,2Z7QC@2	NA|NA|NA	S	Protein of unknown function (DUF3626)
MAG.T21.41_03880	330214.NIDE2938	3.7e-53	214.2	Bacteria													Bacteria	290W2@1,2ZNHX@2	NA|NA|NA		
MAG.T21.41_03883	330214.NIDE2940	5.9e-178	630.9	Bacteria													Bacteria	COG1520@1,COG1520@2	NA|NA|NA	S	amino acid activation for nonribosomal peptide biosynthetic process
MAG.T21.41_03884	330214.NIDE2941	7.1e-127	459.9	Bacteria				ko:K09946					ko00000				Bacteria	COG3422@1,COG3422@2	NA|NA|NA	S	double-strand break repair
MAG.T21.41_03887	234267.Acid_2321	1.4e-11	76.6	Acidobacteria				ko:K03088					ko00000,ko03021				Bacteria	3Y45G@57723,COG1595@1,COG1595@2	NA|NA|NA	K	Belongs to the sigma-70 factor family. ECF subfamily
MAG.T21.41_03888	1125863.JAFN01000001_gene825	1.8e-67	263.1	Deltaproteobacteria													Bacteria	1R9H3@1224,2WT8H@28221,2ZBGR@2,42XHN@68525,arCOG09742@1	NA|NA|NA		
MAG.T21.41_03890	314285.KT71_08555	1.1e-15	90.5	unclassified Gammaproteobacteria													Bacteria	1JAGC@118884,1NVVS@1224,1SPJZ@1236,2EG2Z@1,339UY@2	NA|NA|NA		
MAG.T21.41_03891	566466.NOR53_2459	2.7e-08	65.9	unclassified Gammaproteobacteria													Bacteria	1J9CN@118884,1NU7P@1224,1SMVW@1236,2F075@1,33TAN@2	NA|NA|NA		
MAG.T21.41_03893	330214.NIDE4383	1.2e-175	623.2	Bacteria													Bacteria	COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems, periplasmic component
MAG.T21.41_03894	330214.NIDE4382	4.8e-123	447.2	Nitrospirae	sll1284			ko:K06999					ko00000				Bacteria	3J1DU@40117,COG0400@1,COG0400@2	NA|NA|NA	S	Alpha/beta hydrolase family
MAG.T21.41_03895	330214.NIDE4381	3.6e-129	467.6	Bacteria	MA20_24420			ko:K06889,ko:K07000					ko00000				Bacteria	COG1073@1,COG1073@2	NA|NA|NA	S	thiolester hydrolase activity
MAG.T21.41_03899	330214.NIDE4379	8.3e-132	476.5	Bacteria	MA20_19930			ko:K07226					ko00000				Bacteria	COG0748@1,COG0748@2	NA|NA|NA	P	coenzyme F420 binding
MAG.T21.41_03900	330214.NIDE4378	9.4e-111	406.4	Bacteria													Bacteria	COG2930@1,COG2930@2	NA|NA|NA	S	regulation of ruffle assembly
MAG.T21.41_03901	1160718.SU9_20264	3.6e-26	125.6	Actinobacteria													Bacteria	2DUVD@1,2H1X0@201174,33SHM@2	NA|NA|NA		
MAG.T21.41_03902	1160718.SU9_20264	1.5e-10	72.4	Actinobacteria													Bacteria	2DUVD@1,2H1X0@201174,33SHM@2	NA|NA|NA		
MAG.T21.41_03906	330214.NIDE1587	0.0	1601.6	Bacteria			3.1.3.3	ko:K02038,ko:K02282,ko:K07018,ko:K07315	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000,ko02035,ko02044,ko03021	3.A.1.7			Bacteria	COG0500@1,COG1073@1,COG1073@2,COG2197@1,COG2197@2,COG2226@2,COG5000@1,COG5000@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_03907	330214.NIDE1586	4.5e-156	557.8	Bacteria			2.7.13.3	ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	Gaf domain
MAG.T21.41_03909	1347393.HG726024_gene2967	3.4e-08	66.2	Bacteroidaceae													Bacteria	2FPER@200643,4AP08@815,4NH5X@976,COG0358@1,COG0358@2	NA|NA|NA	L	DNA primase
MAG.T21.41_03910	1340493.JNIF01000004_gene1144	4.3e-36	158.7	Acidobacteria													Bacteria	28KVW@1,2ZACC@2,3Y8V3@57723	NA|NA|NA		
MAG.T21.41_03913	1340493.JNIF01000004_gene1160	1e-114	420.6	Bacteria													Bacteria	COG0464@1,COG0464@2	NA|NA|NA	O	ATPase activity
MAG.T21.41_03915	545695.TREAZ_1519	1e-64	253.4	Spirochaetes	nrdJ		1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2J5M3@203691,COG0209@1,COG0209@2,COG1372@1,COG1372@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T21.41_03916	909663.KI867150_gene2752	3.8e-132	478.4	Syntrophobacterales	traD			ko:K12071					ko00000,ko02044	3.A.7.11.1			Bacteria	1MVGD@1224,2MQV5@213462,2WKY7@28221,42M9J@68525,COG3505@1,COG3505@2	NA|NA|NA	U	TraM recognition site of TraD and TraG
MAG.T21.41_03917	289376.THEYE_A0571	2.8e-45	189.5	Nitrospirae	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659		ko:K06212,ko:K06402					ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3			Bacteria	3J0VG@40117,COG0517@1,COG0517@2,COG1994@1,COG1994@2	NA|NA|NA	S	Belongs to the peptidase M50B family
MAG.T21.41_03919	330214.NIDE1291	1.8e-145	523.1	Nitrospirae	pcrA		3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0VX@40117,COG0210@1,COG0210@2	NA|NA|NA	L	UvrD-like helicase C-terminal domain
MAG.T21.41_03920	330214.NIDE2156	6.6e-35	152.9	Bacteria				ko:K05375,ko:K09190	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002				Bacteria	COG3251@1,COG3251@2	NA|NA|NA	P	PFAM MbtH domain protein
MAG.T21.41_03921	330214.NIDE2155	0.0	1151.0	Bacteria			3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130		R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002				Bacteria	COG2366@1,COG2366@2	NA|NA|NA	D	antibiotic biosynthetic process
MAG.T21.41_03922	330214.NIDE2154	1.6e-161	575.5	Bacteria	rhbA		2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T21.41_03923	330214.NIDE3848	9.3e-29	132.5	Bacteria			2.7.11.1,3.4.21.107	ko:K04771,ko:K14949	ko01503,ko02020,ko05152,map01503,map02020,map05152	M00728			ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T21.41_03925	330214.NIDE3850	3.6e-196	691.0	Bacteria	cpgS			ko:K05716			R03298	RC00900	ko00000,ko01000				Bacteria	COG2403@1,COG2403@2	NA|NA|NA	S	cyclic 2,3-diphosphoglycerate synthetase activity
MAG.T21.41_03927	330214.NIDE2514	2.4e-194	684.9	Bacteria				ko:K03535					ko00000,ko02000	2.A.1.14.1			Bacteria	COG2271@1,COG2271@2	NA|NA|NA	G	transmembrane transporter activity
MAG.T21.41_03928	330214.NIDE2510	3.1e-40	170.6	Bacteria	mazE			ko:K07172,ko:K18842					ko00000,ko02048				Bacteria	COG2336@1,COG2336@2	NA|NA|NA	T	PFAM SpoVT AbrB
MAG.T21.41_03929	330214.NIDE2509	6e-49	199.9	Bacteria	mazF			ko:K07171					ko00000,ko01000,ko02048				Bacteria	COG2337@1,COG2337@2	NA|NA|NA	T	Toxic component of a toxin-antitoxin (TA) module
MAG.T21.41_03930	765913.ThidrDRAFT_4482	9.4e-26	122.5	Chromatiales	namA		1.6.99.1	ko:K00354			R00282	RC00001	ko00000,ko01000				Bacteria	1MVE0@1224,1RMII@1236,1X28K@135613,COG1902@1,COG1902@2	NA|NA|NA	C	PFAM NADH flavin oxidoreductase NADH oxidase
MAG.T21.41_03931	330214.NIDE3592	1.4e-238	832.0	Bacteria	fadL			ko:K06076					ko00000,ko02000	1.B.9			Bacteria	COG2067@1,COG2067@2	NA|NA|NA	I	long-chain fatty acid transporting porin activity
MAG.T21.41_03933	330214.NIDE2544	1.1e-167	595.9	Bacteria													Bacteria	COG4783@1,COG4783@2	NA|NA|NA	L	chaperone-mediated protein folding
MAG.T21.41_03934	330214.NIDE2543	1.8e-165	588.6	Nitrospirae	sppA			ko:K04773					ko00000,ko01000,ko01002				Bacteria	3J13W@40117,COG0616@1,COG0616@2	NA|NA|NA	OU	Peptidase family S49
MAG.T21.41_03935	330214.NIDE2542	7.2e-201	706.4	Nitrospirae	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1383	Bacteria	3J0CS@40117,COG0505@1,COG0505@2	NA|NA|NA	F	Carbamoyl-phosphate synthase small chain, CPSase domain
MAG.T21.41_03937	330214.NIDE2540	3e-224	784.3	Nitrospirae	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0D7@40117,COG0044@1,COG0044@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MAG.T21.41_03938	330214.NIDE2539	8.5e-157	559.7	Nitrospirae	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15490	Bacteria	3J0FJ@40117,COG0540@1,COG0540@2	NA|NA|NA	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
MAG.T21.41_03939	330214.NIDE2538	2.5e-93	348.2	Nitrospirae	pyrR	GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000,ko03000				Bacteria	3J0JX@40117,COG2065@1,COG2065@2	NA|NA|NA	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MAG.T21.41_03940	330214.NIDE2536	0.0	1130.9	Nitrospirae	tkt		2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0MM@40117,COG0021@1,COG0021@2	NA|NA|NA	G	Transketolase, pyrimidine binding domain
MAG.T21.41_03941	330214.NIDE2535	2.4e-99	368.2	Nitrospirae				ko:K10914,ko:K21564	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	3J18E@40117,COG0664@1,COG0664@2	NA|NA|NA	K	helix_turn_helix, cAMP Regulatory protein
MAG.T21.41_03942	330214.NIDE2534	5.5e-159	567.0	Bacteria	aniA		1.16.3.3,1.7.2.1	ko:K00368,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2132@1,COG2132@2	NA|NA|NA	Q	Multicopper oxidase
MAG.T21.41_03944	330214.NIDE2530	1.4e-160	572.4	Bacteria													Bacteria	COG0834@1,COG0834@2	NA|NA|NA	ET	amino acid transport
MAG.T21.41_03945	330214.NIDE2529	3.5e-108	397.9	Bacteria	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02450		M00331			ko00000,ko00002,ko02044	9.B.42			Bacteria	COG3267@1,COG3267@2	NA|NA|NA		
MAG.T21.41_03946	330214.NIDE2528	8.5e-48	196.1	Bacteria													Bacteria	COG0662@1,COG0662@2	NA|NA|NA	G	Cupin 2, conserved barrel domain protein
MAG.T21.41_03947	330214.NIDE2527	5.1e-154	550.4	Nitrospirae	hdrB			ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	3J175@40117,COG2048@1,COG2048@2	NA|NA|NA	C	Cysteine-rich domain
MAG.T21.41_03949	330214.NIDE2525	7.6e-139	500.0	Bacteria													Bacteria	COG1639@1,COG1639@2	NA|NA|NA	T	HDOD domain
MAG.T21.41_03950	1121440.AUMA01000002_gene2147	7.1e-34	150.6	Proteobacteria													Bacteria	1N2HA@1224,COG4627@1,COG4627@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_03951	305900.GV64_15570	2.1e-114	419.1	Oceanospirillales	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	1MUX0@1224,1RMIY@1236,1XIYR@135619,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T21.41_03952	537971.HCCG_02116	3.9e-19	102.1	delta/epsilon subdivisions	eryCVI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983	2.1.1.234	ko:K13311,ko:K13326,ko:K21335	ko00523,ko01130,map00523,map01130	M00797,M00800	R06427,R11045,R11476	RC00003,RC01515,RC02262	ko00000,ko00001,ko00002,ko01000				Bacteria	1N9JV@1224,42TU9@68525,COG0500@1,COG2226@2	NA|NA|NA	Q	Tellurite resistance protein TehB
MAG.T21.41_03953	1286631.X805_32890	6.7e-100	370.9	unclassified Burkholderiales													Bacteria	1KM07@119065,1MUPN@1224,2VJDZ@28216,COG0399@1,COG0399@2	NA|NA|NA	E	DegT/DnrJ/EryC1/StrS aminotransferase family
MAG.T21.41_03954	236097.ADG881_2260	2.5e-29	134.4	Oceanospirillales				ko:K07483,ko:K07497					ko00000				Bacteria	1MZ3D@1224,1S9EI@1236,1XQ9X@135619,COG2963@1,COG2963@2	NA|NA|NA	L	L COG2801 Transposase and inactivated derivatives
MAG.T21.41_03955	1288494.EBAPG3_9990	4.7e-90	337.8	Nitrosomonadales				ko:K07497					ko00000				Bacteria	1MVXQ@1224,2VHER@28216,372VZ@32003,COG2801@1,COG2801@2	NA|NA|NA	L	PFAM Integrase, catalytic
MAG.T21.41_03956	330214.NIDE1715	1.8e-40	172.6	Bacteria													Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
MAG.T21.41_03957	330214.NIDE2479	1.4e-47	195.3	Bacteria				ko:K06950					ko00000				Bacteria	COG1418@1,COG1418@2	NA|NA|NA	S	mRNA catabolic process
MAG.T21.41_03958	330214.NIDE2480	1.8e-158	565.1	Bacteria	desC		1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212		R02222	RC00917	ko00000,ko00001,ko01000,ko01004				Bacteria	COG1398@1,COG1398@2	NA|NA|NA	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
MAG.T21.41_03959	330214.NIDE2481	5.9e-155	553.5	Nitrospirae	mrp			ko:K03593					ko00000,ko03029,ko03036				Bacteria	3J0Z6@40117,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MAG.T21.41_03960	330214.NIDE2482	6.7e-50	203.0	Nitrospirae			1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000				Bacteria	3J1E7@40117,COG2146@1,COG2146@2	NA|NA|NA	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_03962	330214.NIDE1392	0.0	1356.7	Nitrospirae	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0TJ@40117,COG0046@1,COG0046@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T21.41_03963	330214.NIDE1391	2e-121	441.8	Nitrospirae	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	3J10Q@40117,COG0047@1,COG0047@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T21.41_03964	330214.NIDE1390	1.2e-30	138.7	Bacteria	purS		6.3.2.6,6.3.5.3	ko:K01923,ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463,R04591	RC00010,RC00064,RC00162,RC01160	ko00000,ko00001,ko00002,ko01000			iYO844.BSU06460	Bacteria	COG1828@1,COG1828@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T21.41_03966	330214.NIDE1388	9.9e-121	439.5	Nitrospirae	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464	4.1.1.21,4.3.2.2,6.3.2.6	ko:K01587,ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04209,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445,RC00590	ko00000,ko00001,ko00002,ko01000			iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735	Bacteria	3J0U6@40117,COG0152@1,COG0152@2	NA|NA|NA	F	SAICAR synthetase
MAG.T21.41_03967	330214.NIDE1387	2.5e-96	358.6	Bacteria		GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114	1.13.11.49	ko:K09162					ko00000,ko01000				Bacteria	COG3253@1,COG3253@2	NA|NA|NA	S	peroxidase activity
MAG.T21.41_03968	330214.NIDE1386	1.2e-236	825.5	Nitrospirae	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1095,iSB619.SA_RS09895	Bacteria	3J0EM@40117,COG0015@1,COG0015@2	NA|NA|NA	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MAG.T21.41_03969	330214.NIDE1385	2.7e-74	284.6	Nitrospirae	nusB			ko:K03625					ko00000,ko03009,ko03021				Bacteria	3J0RV@40117,COG0781@1,COG0781@2	NA|NA|NA	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MAG.T21.41_03970	330214.NIDE1384	1.1e-79	302.8	Nitrospirae	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1825,iSB619.SA_RS08940,iSFV_1184.SFV_0380	Bacteria	3J0QT@40117,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MAG.T21.41_03971	330214.NIDE1383	5.1e-202	710.3	Nitrospirae	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K01497,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS10830,iSB619.SA_RS08945	Bacteria	3J0E0@40117,COG0108@1,COG0108@2,COG0807@1,COG0807@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAG.T21.41_03972	330214.NIDE1382	5.4e-167	594.0	Nitrospirae	nasA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iYO844.BSU03330	Bacteria	3J0YQ@40117,COG2223@1,COG2223@2	NA|NA|NA	P	Major Facilitator Superfamily
MAG.T21.41_03973	330214.NIDE1381	1e-158	566.2	Bacteria	rpoH			ko:K03089					ko00000,ko03021				Bacteria	COG0568@1,COG0568@2	NA|NA|NA	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T21.41_03974	330214.NIDE1380	5e-250	870.2	Bacteria	pilL			ko:K02487,ko:K20276	ko02020,ko02024,map02020,map02024	M00507			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG3266@1,COG3266@2	NA|NA|NA	GM	domain, Protein
MAG.T21.41_03975	330214.NIDE1379	5.2e-47	193.4	Nitrospirae	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220		ko:K04078					ko00000,ko03029,ko03110				Bacteria	3J0RF@40117,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MAG.T21.41_03976	330214.NIDE1378	2.4e-295	1020.8	Nitrospirae	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	3J0DA@40117,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MAG.T21.41_03977	330214.NIDE1377	8e-284	982.6	Bacteria	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982					ko00000,ko01000				Bacteria	COG1391@1,COG1391@2	NA|NA|NA	H	[glutamate-ammonia-ligase] adenylyltransferase activity
MAG.T21.41_03978	330214.NIDE1376	0.0	1324.7	Bacteria	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89	ko:K00003,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020	M00017,M00018	R00243,R01773,R01775	RC00006,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1391@1,COG1391@2,COG2844@1,COG2844@2	NA|NA|NA	H	[glutamate-ammonia-ligase] adenylyltransferase activity
MAG.T21.41_03981	330214.NIDE1370	2.3e-175	621.7	Bacteria													Bacteria	2CK9T@1,2Z7W9@2	NA|NA|NA		
MAG.T21.41_03982	330214.NIDE1368	5.9e-119	433.7	Bacteria	opuCA		2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12			Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_03983	330214.NIDE1367	4.8e-272	943.3	Nitrospirae	nirA		1.7.7.1	ko:K00366	ko00910,ko01120,map00910,map01120	M00531	R00790	RC00176	ko00000,ko00001,ko00002,ko01000				Bacteria	3J10S@40117,COG0155@1,COG0155@2	NA|NA|NA	C	Nitrite and sulphite reductase 4Fe-4S domain
MAG.T21.41_03985	330214.NIDE1365	1.6e-73	282.0	Bacteria	cynS		4.2.1.104	ko:K01725	ko00910,map00910		R03546,R10079	RC00952	ko00000,ko00001,ko01000				Bacteria	COG1513@1,COG1513@2	NA|NA|NA	P	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MAG.T21.41_03986	330214.NIDE1364	4.5e-141	507.3	Bacteria	nirC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02598,ko:K06212,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3		iSF_1195.SF3386,iS_1188.S4377	Bacteria	COG2116@1,COG2116@2	NA|NA|NA	P	formate transmembrane transporter activity
MAG.T21.41_03987	330214.NIDE1363	2.5e-277	960.7	Nitrospirae	glnA		6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	3J0AS@40117,COG0174@1,COG0174@2	NA|NA|NA	E	Glutamine synthetase, catalytic domain
MAG.T21.41_03988	330214.NIDE1362	2.9e-302	1043.9	Bacteria	glnD		2.7.7.42,2.7.7.59,2.7.7.89	ko:K00982,ko:K00990	ko02020,map02020				ko00000,ko00001,ko01000				Bacteria	COG2844@1,COG2844@2	NA|NA|NA	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MAG.T21.41_03989	288000.BBta_1460	2.3e-187	662.1	Alphaproteobacteria													Bacteria	1R3NX@1224,2VGSR@28211,COG5421@1,COG5421@2	NA|NA|NA	L	Transposase DDE domain
MAG.T21.41_03990	452637.Oter_3872	1.9e-126	458.8	Opitutae	ywqD		2.7.10.1	ko:K08252,ko:K13661,ko:K16554	ko05111,map05111				ko00000,ko00001,ko01000,ko02000	8.A.3.1			Bacteria	3KA2W@414999,46TJK@74201,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	D	AAA domain
MAG.T21.41_03991	330214.NIDE3607	2.6e-25	120.9	Bacteria				ko:K20977	ko02020,ko02025,map02020,map02025	M00820			ko00000,ko00001,ko00002,ko02022				Bacteria	COG0745@1,COG0745@2,COG2172@1,COG2172@2	NA|NA|NA	T	sigma factor antagonist activity
MAG.T21.41_03992	330214.NIDE3608	2.9e-225	787.7	Bacteria													Bacteria	COG1874@1,COG1874@2	NA|NA|NA	G	beta-galactosidase activity
MAG.T21.41_03993	330214.NIDE3609	1.2e-144	519.2	Bacteria													Bacteria	COG4221@1,COG4221@2	NA|NA|NA	IQ	oxidoreductase activity
MAG.T21.41_03995	1235457.C404_24060	9e-186	656.8	Burkholderiaceae	pitA			ko:K03306					ko00000	2.A.20			Bacteria	1K3WI@119060,1MVXK@1224,2VI71@28216,COG0306@1,COG0306@2	NA|NA|NA	P	phosphate transporter
MAG.T21.41_03996	644282.Deba_1508	4.7e-08	65.1	Deltaproteobacteria													Bacteria	1NNP4@1224,2WRZ3@28221,42VPE@68525,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_03997	1121405.dsmv_1639	6.3e-79	301.2	Desulfobacterales	lgt			ko:K13292					ko00000,ko01000				Bacteria	1NB9I@1224,2MIP1@213118,2WJU5@28221,42M7E@68525,COG0682@1,COG0682@2	NA|NA|NA	M	PFAM prolipoprotein diacylglyceryl transferase
MAG.T21.41_03998	338963.Pcar_2301	2.5e-109	402.1	Desulfuromonadales	psd		4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVT4@1224,2WJV9@28221,42PAW@68525,43TFP@69541,COG0688@1,COG0688@2	NA|NA|NA	I	Belongs to the phosphatidylserine decarboxylase family
MAG.T21.41_03999	439235.Dalk_0524	3.1e-235	821.6	Desulfobacterales			4.1.3.25,4.1.3.34	ko:K01644,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020		R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000				Bacteria	1NAM2@1224,2MJ35@213118,2WJIP@28221,42P8P@68525,COG2301@1,COG2301@2	NA|NA|NA	G	Belongs to the HpcH HpaI aldolase family
MAG.T21.41_04000	330214.NIDE1522	6.2e-40	171.0	Nitrospirae	yieH		3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	3J15X@40117,COG0637@1,COG0637@2	NA|NA|NA	S	Haloacid dehalogenase-like hydrolase
MAG.T21.41_04001	330214.NIDE3611	2.2e-162	578.6	Bacteria	yagE												Bacteria	COG1723@1,COG1723@2	NA|NA|NA	S	PFAM Uncharacterised ACR, YagE family COG1723
MAG.T21.41_04002	330214.NIDE3612	2.7e-187	661.4	Bacteria													Bacteria	2C8FN@1,2ZBER@2	NA|NA|NA		
MAG.T21.41_04003	330214.NIDE3614	9.1e-160	569.7	Bacteria													Bacteria	COG3137@1,COG3137@2	NA|NA|NA		
MAG.T21.41_04004	330214.NIDE3615	6.7e-192	676.8	Nitrospirae				ko:K07007					ko00000				Bacteria	3J12U@40117,COG2081@1,COG2081@2	NA|NA|NA	S	HI0933-like protein
MAG.T21.41_04006	330214.NIDE2515	5.7e-118	432.6	Bacteria				ko:K07290					ko00000	9.B.121			Bacteria	COG2982@1,COG2982@2	NA|NA|NA	M	Protein involved in outer membrane biogenesis
MAG.T21.41_04007	330214.NIDE3616	1.4e-110	406.0	Bacteria			3.5.1.53	ko:K11206,ko:K12251	ko00330,ko01100,map00330,map01100		R01152	RC00096	ko00000,ko00001,ko01000				Bacteria	COG0388@1,COG0388@2	NA|NA|NA	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
MAG.T21.41_04009	330214.NIDE3617	1.4e-69	269.2	Bacteria			1.3.1.75	ko:K07002,ko:K19073	ko00860,ko01100,ko01110,map00860,map01100,map01110		R06272,R06896	RC01376	ko00000,ko00001,ko01000				Bacteria	COG3545@1,COG3545@2	NA|NA|NA	S	Serine hydrolase
MAG.T21.41_04010	330214.NIDE3618	6e-198	696.8	Bacteria				ko:K07007					ko00000				Bacteria	COG2081@1,COG2081@2	NA|NA|NA	N	HI0933 family
MAG.T21.41_04011	330214.NIDE3619	3.9e-47	194.5	Nitrospirae													Bacteria	29KDN@1,307AY@2,3J14Y@40117	NA|NA|NA		
MAG.T21.41_04012	330214.NIDE3620	4.2e-51	207.6	Bacteria	aacA7	GO:0003674,GO:0003824,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0034069,GO:0042221,GO:0046677,GO:0047663,GO:0050896	2.3.1.82	ko:K18816					br01600,ko00000,ko01000,ko01504				Bacteria	COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
MAG.T21.41_04013	330214.NIDE3621	1.7e-70	272.3	Bacteria	ompW			ko:K07275					ko00000				Bacteria	COG3047@1,COG3047@2	NA|NA|NA		
MAG.T21.41_04014	330214.NIDE3622	7e-239	833.2	Bacteria				ko:K03316					ko00000	2.A.36			Bacteria	COG0025@1,COG0025@2	NA|NA|NA	P	sodium:proton antiporter activity
MAG.T21.41_04015	330214.NIDE3623	8.3e-135	486.5	Bacteria	ytbE												Bacteria	COG0656@1,COG0656@2	NA|NA|NA	S	aldo-keto reductase (NADP) activity
MAG.T21.41_04017	670292.JH26_11125	1.7e-60	239.2	Alphaproteobacteria													Bacteria	1RA3U@1224,2U640@28211,COG1028@1,COG1028@2	NA|NA|NA	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MAG.T21.41_04018	330214.NIDE3627	2.1e-157	562.0	Bacteria	yhaZ												Bacteria	COG4335@1,COG4335@2	NA|NA|NA	L	DNA alkylation repair
MAG.T21.41_04019	330214.NIDE3628	2.7e-51	208.0	Bacteria	yciH	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K03113	ko03013,map03013				ko00000,ko00001,ko03012				Bacteria	COG0023@1,COG0023@2	NA|NA|NA	J	translation initiation factor activity
MAG.T21.41_04020	330214.NIDE3629	1.4e-85	322.4	Bacteria	yaeQ												Bacteria	COG4681@1,COG4681@2	NA|NA|NA	S	YaeQ
MAG.T21.41_04021	330214.NIDE3630	9.2e-34	149.1	Bacteria	YPO1157	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363		ko:K06867					ko00000				Bacteria	COG4628@1,COG4628@2	NA|NA|NA	S	conserved protein (DUF2132)
MAG.T21.41_04022	330214.NIDE3631	2.8e-134	484.6	Bacteria													Bacteria	COG1403@1,COG1403@2	NA|NA|NA	V	endonuclease activity
MAG.T21.41_04024	330214.NIDE3635	1.5e-302	1044.6	Nitrospirae	prfC	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02837,ko:K07133					ko00000,ko03012				Bacteria	3J0WP@40117,COG4108@1,COG4108@2	NA|NA|NA	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MAG.T21.41_04025	313612.L8106_02157	5.5e-16	92.4	Oscillatoriales													Bacteria	1G3Y8@1117,1H8QZ@1150,COG2755@1,COG2755@2	NA|NA|NA	E	SGNH hydrolase-like domain, acetyltransferase AlgX
MAG.T21.41_04027	330214.NIDE3638	2.2e-59	235.3	Bacteria													Bacteria	COG0464@1,COG0464@2	NA|NA|NA	O	ATPase activity
MAG.T21.41_04028	330214.NIDE3639	3.5e-288	996.9	Bacteria	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	COG1061@1,COG1061@2	NA|NA|NA	L	Type III restriction enzyme res subunit
MAG.T21.41_04034	330214.NIDE3547	7.3e-100	370.2	Nitrospirae													Bacteria	3J133@40117,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_04035	1356854.N007_16670	1.7e-29	136.0	Alicyclobacillaceae	radC			ko:K03630					ko00000				Bacteria	1V38E@1239,27ANZ@186823,4HG4Q@91061,COG2003@1,COG2003@2	NA|NA|NA	L	RadC-like JAB domain
MAG.T21.41_04039	1123279.ATUS01000001_gene2720	1.2e-18	100.9	Gammaproteobacteria				ko:K10954	ko05110,map05110				ko00000,ko00001,ko02042				Bacteria	1RCY8@1224,1S4JQ@1236,COG4128@1,COG4128@2	NA|NA|NA	S	Zonular occludens toxin (Zot)
MAG.T21.41_04043	330214.NIDE0337	4.8e-89	334.7	Bacteria	nicK			ko:K07467					ko00000				Bacteria	COG2946@1,COG2946@2	NA|NA|NA	L	Replication initiation factor
MAG.T21.41_04045	1323663.AROI01000002_gene1189	0.0	1629.0	Gammaproteobacteria													Bacteria	1NC5H@1224,1RRXS@1236,COG0553@1,COG0553@2	NA|NA|NA	L	helicase
MAG.T21.41_04046	511.JT27_01325	3.4e-59	235.0	Alcaligenaceae													Bacteria	1R0GZ@1224,28NQ0@1,2WA31@28216,2ZBPR@2,3T4CX@506	NA|NA|NA	S	Domain of unknown function (DUF4391)
MAG.T21.41_04047	266779.Meso_0543	8.7e-191	673.7	Alphaproteobacteria	mod		2.1.1.72	ko:K07316					ko00000,ko01000,ko02048				Bacteria	1MX9M@1224,2U066@28211,COG2189@1,COG2189@2	NA|NA|NA	L	dna methylase
MAG.T21.41_04052	411684.HPDFL43_21819	3.3e-100	372.5	Phyllobacteriaceae													Bacteria	1R5SA@1224,2U4AI@28211,43P0X@69277,COG0582@1,COG0582@2	NA|NA|NA	L	Phage integrase family
MAG.T21.41_04055	1267535.KB906767_gene210	2.4e-86	325.9	Bacteria	nhaA			ko:K03313					ko00000,ko02000	2.A.33.1			Bacteria	COG3004@1,COG3004@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MAG.T21.41_04057	330214.NIDE3131	3.8e-136	491.1	Nitrospirae				ko:K22044					ko00000,ko02000	1.A.23.3			Bacteria	3J0YK@40117,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive ion channel
MAG.T21.41_04058	330214.NIDE3129	6.2e-295	1019.6	Nitrospirae													Bacteria	3J13U@40117,COG1960@1,COG1960@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04059	330214.NIDE3128	1.7e-251	875.2	Bacteria			6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	COG0318@1,COG0318@2	NA|NA|NA	IQ	PFAM AMP-dependent synthetase and ligase
MAG.T21.41_04060	330214.NIDE3127	2.7e-163	581.6	Bacteria	prpC	GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630	Bacteria	COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T21.41_04061	330214.NIDE3126	5.2e-106	391.0	Bacteria	prpB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.1.3.30	ko:K03417	ko00640,map00640		R00409	RC00286,RC00287	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407	Bacteria	COG2513@1,COG2513@2	NA|NA|NA	G	methylisocitrate lyase activity
MAG.T21.41_04062	330214.NIDE3125	1.6e-183	649.0	Bacteria	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640		R04424	RC01152	ko00000,ko00001,ko01000				Bacteria	COG2079@1,COG2079@2	NA|NA|NA	S	2-methylcitrate dehydratase activity
MAG.T21.41_04063	330214.NIDE3124	1.2e-85	323.2	Bacteria	argK			ko:K07588					ko00000,ko01000				Bacteria	COG1703@1,COG1703@2	NA|NA|NA	E	isobutyryl-CoA mutase activity
MAG.T21.41_04064	330214.NIDE3123	6.8e-125	453.8	Bacteria	mvaB	GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224	4.1.3.4,6.4.1.4	ko:K01640,ko:K01968	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R04138,R08090	RC00367,RC00502,RC00503,RC00942,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_3293	Bacteria	COG0119@1,COG0119@2	NA|NA|NA	E	Belongs to the alpha-IPM synthase homocitrate synthase family
MAG.T21.41_04065	330214.NIDE3122	2.3e-84	318.9	Bacteria	atuE		4.2.1.18,4.2.1.57	ko:K13766,ko:K13779	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R02085,R03493	RC00941,RC02416	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase
MAG.T21.41_04066	330214.NIDE3121	9.3e-260	902.5	Bacteria	mccB		2.1.3.15,6.4.1.3,6.4.1.4,6.4.1.5	ko:K01969,ko:K13778,ko:K15052	ko00280,ko00281,ko00720,ko01100,ko01200,map00280,map00281,map00720,map01100,map01200	M00036,M00376	R01859,R03494,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_3290	Bacteria	COG4799@1,COG4799@2	NA|NA|NA	I	CoA carboxylase activity
MAG.T21.41_04067	330214.NIDE3120	6e-62	243.4	Bacteria			5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2185@1,COG2185@2	NA|NA|NA	I	cobalamin binding
MAG.T21.41_04068	330214.NIDE3119	1.5e-128	465.7	Nitrospirae	ytnP												Bacteria	3J1C9@40117,COG0491@1,COG0491@2	NA|NA|NA	S	Metallo-beta-lactamase superfamily
MAG.T21.41_04069	330214.NIDE3118	1.7e-269	934.9	Bacteria	icmA		5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1884@1,COG1884@2	NA|NA|NA	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAG.T21.41_04071	330214.NIDE2212	3.4e-261	907.5	Bacteria													Bacteria	COG1075@1,COG1075@2,COG4995@1,COG4995@2	NA|NA|NA	S	CHAT domain
MAG.T21.41_04076	330214.NIDE2211	3.1e-138	498.0	Bacteria	rmlA	GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.7.13,2.7.7.24,2.7.7.99	ko:K00966,ko:K00973,ko:K00992	ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130	M00114,M00361,M00362,M00793	R00885,R02328,R11025	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1208@1,COG1208@2	NA|NA|NA	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MAG.T21.41_04077	330214.NIDE2210	1.3e-61	243.0	Bacteria			2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4	ko:K00543,ko:K16130,ko:K18896,ko:K18897,ko:K21515	ko00260,ko00380,ko01054,ko01100,map00260,map00380,map01054,map01100	M00037	R03130,R04905,R10060,R10061	RC00003,RC00392,RC03038,RC03040	ko00000,ko00001,ko00002,ko01000,ko01008,ko03009				Bacteria	COG2890@1,COG2890@2	NA|NA|NA	J	protein-(glutamine-N5) methyltransferase activity
MAG.T21.41_04078	269799.Gmet_0658	6.6e-120	437.2	Deltaproteobacteria	ybhF-N			ko:K01990,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MUX3@1224,2WKFC@28221,42PIB@68525,COG1131@1,COG1131@2	NA|NA|NA	V	Abc transporter
MAG.T21.41_04079	1304885.AUEY01000027_gene2343	4.9e-74	285.0	Desulfobacterales	ybhG			ko:K01993,ko:K02005					ko00000				Bacteria	1QU7Z@1224,2MPNH@213118,2X70W@28221,43BPM@68525,COG1566@1,COG1566@2	NA|NA|NA	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion
MAG.T21.41_04080	330214.NIDE3915	1.8e-211	741.9	Nitrospirae													Bacteria	3J19C@40117,COG1538@1,COG1538@2	NA|NA|NA	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04081	1294143.H681_09730	1.6e-74	285.8	Gammaproteobacteria													Bacteria	1MWF7@1224,1RPZ6@1236,COG1309@1,COG1309@2	NA|NA|NA	D	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
MAG.T21.41_04082	330214.NIDE0872	8.6e-198	696.8	Nitrospirae				ko:K03455					ko00000	2.A.37			Bacteria	3J12F@40117,COG0475@1,COG0475@2,COG1226@1,COG1226@2	NA|NA|NA	P	TrkA-N domain
MAG.T21.41_04083	686340.Metal_1712	0.0	1107.0	Methylococcales	ctpF												Bacteria	1MUU5@1224,1RMYC@1236,1XDXD@135618,COG0474@1,COG0474@2	NA|NA|NA	P	TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter
MAG.T21.41_04084	987059.RBXJA2T_13976	1.5e-49	203.4	Betaproteobacteria	uspA												Bacteria	1PE08@1224,2VNHV@28216,COG0589@1,COG0589@2	NA|NA|NA	T	universal stress protein
MAG.T21.41_04085	330214.NIDE1927	1.3e-32	147.1	Nitrospirae	mntH			ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3			Bacteria	3J1A7@40117,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
MAG.T21.41_04086	330214.NIDE3916	0.0	1760.3	Nitrospirae													Bacteria	3J0VZ@40117,COG0841@1,COG0841@2	NA|NA|NA	V	AcrB/AcrD/AcrF family
MAG.T21.41_04087	330214.NIDE3917	1.4e-137	496.1	Nitrospirae													Bacteria	3J13X@40117,COG0845@1,COG0845@2	NA|NA|NA	M	HlyD family secretion protein
MAG.T21.41_04088	1268239.PALB_1730	2.6e-12	77.4	Pseudoalteromonadaceae													Bacteria	1N6NN@1224,1SCRA@1236,2Q3DA@267888,32YCZ@2,COG0607@1	NA|NA|NA	P	COG0607 Rhodanese-related sulfurtransferase
MAG.T21.41_04089	330214.NIDE3919	8e-172	609.8	Bacteria													Bacteria	2FARP@1,342Z3@2	NA|NA|NA		
MAG.T21.41_04090	330214.NIDE3920	5.7e-133	480.3	Bacteria				ko:K07090					ko00000				Bacteria	COG0730@1,COG0730@2	NA|NA|NA	S	response to heat
MAG.T21.41_04091	330214.NIDE3925	4.3e-236	823.5	Nitrospirae	sqr	GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114	1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	3J102@40117,COG0446@1,COG0446@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase
MAG.T21.41_04092	330214.NIDE3926	2.3e-90	338.6	Bacteria			2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG5278@1,COG5278@2	NA|NA|NA	T	phosphoserine phosphatase activity
MAG.T21.41_04093	330214.NIDE3927	1.4e-57	229.2	Bacteria													Bacteria	COG5615@1,COG5615@2	NA|NA|NA	L	integral membrane protein
MAG.T21.41_04094	330214.NIDE3929	1.3e-120	439.1	Bacteria	zapB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301	2.1.1.80,3.1.1.61	ko:K09892,ko:K13924	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03036				Bacteria	COG3074@1,COG3074@2	NA|NA|NA	D	FtsZ-dependent cytokinesis
MAG.T21.41_04096	330214.NIDE3933	1.9e-116	425.2	Bacteria	crp			ko:K01420,ko:K10914,ko:K21556,ko:K21562	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	COG0664@1,COG0664@2	NA|NA|NA	T	cyclic nucleotide binding
MAG.T21.41_04097	330214.NIDE3934	7e-170	603.2	Bacteria													Bacteria	COG1262@1,COG1262@2	NA|NA|NA	T	PFAM Formylglycine-generating sulfatase enzyme
MAG.T21.41_04098	330214.NIDE3935	3.5e-150	537.7	Nitrospirae													Bacteria	3J14J@40117,COG1262@1,COG1262@2	NA|NA|NA	S	Evidence 4 Homologs of previously reported genes of
MAG.T21.41_04099	330214.NIDE3936	4e-170	604.0	Bacteria													Bacteria	COG3794@1,COG3794@2	NA|NA|NA	C	PFAM blue (type 1) copper domain protein
MAG.T21.41_04100	228405.HNE_1557	1.6e-79	302.4	Hyphomonadaceae	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016830,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0061798,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394	RC03420	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2571,ic_1306.c0862	Bacteria	1MW3W@1224,2TQQP@28211,43ZGX@69657,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAG.T21.41_04101	228405.HNE_1556	1.2e-131	476.5	Hyphomonadaceae				ko:K07234					ko00000				Bacteria	1MUJK@1224,2TSQ2@28211,43XJH@69657,COG3213@1,COG3213@2	NA|NA|NA	P	protein involved in response to NO
MAG.T21.41_04102	1280944.HY17_08085	0.0	1139.0	Hyphomonadaceae	nrdZ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	1MUJ8@1224,2TS19@28211,43Z9Z@69657,COG0209@1,COG0209@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T21.41_04103	1280952.HJA_03871	1.2e-45	189.1	Hyphomonadaceae			3.3.2.8	ko:K10533	ko00903,map00903		R05784,R09387	RC01473,RC02519	ko00000,ko00001,ko01000				Bacteria	1RJ3T@1224,2UAH6@28211,440IB@69657,COG4308@1,COG4308@2	NA|NA|NA	Q	Limonene-1,2-epoxide hydrolase
MAG.T21.41_04104	228405.HNE_1553	2.6e-34	151.8	Hyphomonadaceae	moeA1		2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	1MVD5@1224,2TQRI@28211,43WDU@69657,COG0303@1,COG0303@2	NA|NA|NA	H	molybdopterin biosynthesis
MAG.T21.41_04107	1057002.KB905370_gene3670	1.1e-123	450.7	Rhizobiaceae	nolO			ko:K00612					ko00000,ko01000				Bacteria	1MWBA@1224,2TV6G@28211,4BCY5@82115,COG2192@1,COG2192@2	NA|NA|NA	O	Carbamoyltransferase C-terminus
MAG.T21.41_04108	1470591.BW41_03716	2.1e-28	133.3	Sphingomonadales													Bacteria	1MWMZ@1224,2JZZ5@204457,2TVFK@28211,COG0726@1,COG0726@2	NA|NA|NA	G	polysaccharide deacetylase
MAG.T21.41_04109	330214.NIDE0876	7e-94	350.1	Bacteria				ko:K10936,ko:K16079	ko05111,map05111				ko00000,ko00001,ko02000	1.B.4.2.1			Bacteria	COG3637@1,COG3637@2	NA|NA|NA	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MAG.T21.41_04110	886379.AEWI01000012_gene1151	1.7e-09	71.6	Marinilabiliaceae													Bacteria	28NIY@1,2FQNB@200643,2ZBK8@2,3XIYD@558415,4NM7G@976	NA|NA|NA		
MAG.T21.41_04111	330214.NIDE3409	1.4e-23	115.9	Bacteria				ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	COG1734@1,COG1734@2	NA|NA|NA	T	zinc ion binding
MAG.T21.41_04115	330214.NIDE3413	3.3e-33	147.9	Bacteria													Bacteria	COG0451@1,COG0451@2,COG0673@1,COG0673@2	NA|NA|NA	S	inositol 2-dehydrogenase activity
MAG.T21.41_04118	330214.NIDE0213	5.7e-36	157.5	Bacteria													Bacteria	2CH72@1,32ZK4@2	NA|NA|NA	S	Protein of unknown function (DUF2878)
MAG.T21.41_04119	330214.NIDE0212	6.2e-185	653.7	Bacteria	cfa		2.1.1.317,2.1.1.79	ko:K00574,ko:K20238					ko00000,ko01000			iJN746.PP_2734	Bacteria	COG2230@1,COG2230@2	NA|NA|NA	M	cyclopropane-fatty-acyl-phospholipid synthase
MAG.T21.41_04120	330214.NIDE0211	4.6e-111	407.5	Bacteria			2.1.1.79	ko:K00574,ko:K09701					ko00000,ko01000				Bacteria	COG3496@1,COG3496@2	NA|NA|NA	S	Protein of unknown function (DUF1365)
MAG.T21.41_04121	330214.NIDE0210	5.4e-194	683.7	Bacteria				ko:K06954					ko00000				Bacteria	COG2907@1,COG2907@2	NA|NA|NA	S	Flavin containing amine oxidoreductase
MAG.T21.41_04122	330214.NIDE0209	1.4e-99	369.4	Nitrospirae	sdh												Bacteria	3J1EK@40117,COG0300@1,COG0300@2	NA|NA|NA	C	Enoyl-(Acyl carrier protein) reductase
MAG.T21.41_04123	330214.NIDE0208	3e-45	188.0	Bacteria			5.3.3.1	ko:K01822,ko:K21972	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	COG3631@1,COG3631@2	NA|NA|NA	S	light absorption
MAG.T21.41_04124	330214.NIDE0207	7.5e-66	256.9	Bacteria													Bacteria	2E01F@1,32VQP@2	NA|NA|NA	S	Chalcone isomerase-like
MAG.T21.41_04125	330214.NIDE0206	1e-71	276.2	Bacteria													Bacteria	COG2138@1,COG2138@2	NA|NA|NA	S	sirohydrochlorin cobaltochelatase activity
MAG.T21.41_04126	330214.NIDE0204	1.8e-162	578.6	Nitrospirae	ybgA												Bacteria	3J13F@40117,COG1683@1,COG1683@2,COG3272@1,COG3272@2	NA|NA|NA	S	Protein of unknown function (DUF1722)
MAG.T21.41_04127	330214.NIDE0203	3.7e-107	394.8	Nitrospirae	phr		4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Bacteria	3J0IW@40117,COG0415@1,COG0415@2	NA|NA|NA	H	Belongs to the DNA photolyase family
MAG.T21.41_04128	330214.NIDE1368	8.1e-08	63.5	Bacteria	opuCA		2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12			Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_04129	330214.NIDE3650	4.8e-103	380.9	Bacteria	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K00406,ko:K03889	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00151,M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome c
MAG.T21.41_04130	330214.NIDE3647	9.1e-96	356.3	Bacteria	ompW			ko:K07275					ko00000				Bacteria	COG3047@1,COG3047@2	NA|NA|NA		
MAG.T21.41_04131	330214.NIDE3646	2.6e-61	241.5	Bacteria	acuB			ko:K04767,ko:K07182					ko00000				Bacteria	COG0517@1,COG0517@2	NA|NA|NA	S	IMP dehydrogenase activity
MAG.T21.41_04132	330214.NIDE3643	2.5e-121	441.4	Nitrospirae	ppa		3.6.1.1	ko:K01507	ko00190,map00190				ko00000,ko00001,ko01000				Bacteria	3J184@40117,COG0221@1,COG0221@2	NA|NA|NA	C	Inorganic pyrophosphatase
MAG.T21.41_04133	330214.NIDE3642	1.8e-296	1024.6	Bacteria	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0032574,GO:0032575,GO:0033554,GO:0033592,GO:0034057,GO:0034248,GO:0034250,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05592	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	COG0513@1,COG0513@2	NA|NA|NA	L	helicase activity
MAG.T21.41_04134	1535422.ND16A_1874	1.7e-54	219.2	Gammaproteobacteria													Bacteria	1MWPR@1224,1S7W4@1236,COG1765@1,COG1765@2	NA|NA|NA	O	OsmC-like protein
MAG.T21.41_04135	1123368.AUIS01000032_gene1401	2.7e-28	131.7	Gammaproteobacteria													Bacteria	1N688@1224,1SS8Q@1236,2D5Q1@1,32TJK@2	NA|NA|NA		
MAG.T21.41_04136	404589.Anae109_0601	3.1e-51	208.4	Myxococcales				ko:K15836					ko00000,ko03000				Bacteria	1NU8B@1224,2X6YU@28221,2YYW6@29,43BKG@68525,COG3829@1,COG3829@2	NA|NA|NA	K	ATPase associated with various cellular activities, AAA_5
MAG.T21.41_04138	330214.NIDE3531	2e-126	458.8	Nitrospirae	cynR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K11921					ko00000,ko03000				Bacteria	3J16P@40117,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_04139	330214.NIDE3532	1.1e-120	439.5	Bacteria				ko:K07140					ko00000				Bacteria	COG3217@1,COG3217@2	NA|NA|NA	S	molybdenum ion binding
MAG.T21.41_04140	330214.NIDE3533	8.8e-101	373.2	Bacteria	yiiM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754											Bacteria	COG2258@1,COG2258@2	NA|NA|NA	C	MOSC domain
MAG.T21.41_04143	330214.NIDE3536	8.3e-43	179.9	Bacteria													Bacteria	COG2204@1,COG2204@2	NA|NA|NA	T	phosphorelay signal transduction system
MAG.T21.41_04144	330214.NIDE3537	5.4e-140	504.2	Nitrospirae	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63,3.2.2.21	ko:K00567,ko:K10778,ko:K13529,ko:K13530,ko:K15051	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	3J14M@40117,COG0350@1,COG0350@2,COG2169@1,COG2169@2	NA|NA|NA	L	helix_turn_helix, arabinose operon control protein
MAG.T21.41_04146	330214.NIDE2876	5.9e-149	533.9	Bacteria													Bacteria	COG2755@1,COG2755@2	NA|NA|NA	E	lipolytic protein G-D-S-L family
MAG.T21.41_04147	420324.KI912033_gene2604	1.8e-75	289.3	Methylobacteriaceae				ko:K07497					ko00000				Bacteria	1JXCN@119045,1MWNX@1224,2VF51@28211,COG2801@1,COG2801@2	NA|NA|NA	L	PFAM integrase
MAG.T21.41_04149	330214.NIDE2245	3.4e-204	717.6	Bacteria													Bacteria	COG0348@1,COG0348@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
MAG.T21.41_04150	330214.NIDE4010	4.2e-24	117.9	Bacteria													Bacteria	COG0582@1,COG0582@2	NA|NA|NA	L	DNA integration
MAG.T21.41_04151	644801.Psest_2710	1.1e-07	64.3	Pseudomonas stutzeri group	rsbP		3.1.3.3	ko:K07315					ko00000,ko01000,ko03021				Bacteria	1R3UE@1224,1RRJX@1236,1Z1A0@136846,COG0745@1,COG0745@2,COG2208@1,COG2208@2	NA|NA|NA	KT	COG0784 FOG CheY-like receiver
MAG.T21.41_04154	478741.JAFS01000001_gene1547	3.6e-77	295.0	Bacteria													Bacteria	2FBN7@1,343TB@2	NA|NA|NA		
MAG.T21.41_04155	1149133.ppKF707_0650	3.9e-13	81.3	Pseudomonas aeruginosa group													Bacteria	1N130@1224,1S98I@1236,1YGCT@136841,2CECF@1,32RZM@2	NA|NA|NA	S	pilin assembly protein
MAG.T21.41_04156	330214.NIDE0337	2.1e-132	478.8	Bacteria	nicK			ko:K07467					ko00000				Bacteria	COG2946@1,COG2946@2	NA|NA|NA	L	Replication initiation factor
MAG.T21.41_04157	330214.NIDE0336	2.2e-27	128.3	Bacteria				ko:K02806	ko02060,map02060				ko00000,ko00001,ko01000,ko02000				Bacteria	COG3311@1,COG3311@2	NA|NA|NA	K	DNA excision
MAG.T21.41_04158	330214.NIDE3547	5.2e-37	160.6	Nitrospirae													Bacteria	3J133@40117,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T21.41_04159	1500306.JQLA01000075_gene129	1.5e-20	105.1	Rhizobiaceae													Bacteria	1MUVI@1224,2TSA7@28211,4BBSC@82115,COG3039@1,COG3039@2	NA|NA|NA	L	Transposase domain (DUF772)
MAG.T21.41_04160	991905.SL003B_2792	2.2e-54	219.9	unclassified Alphaproteobacteria	rkpU			ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Bacteria	1N7GP@1224,2TS5Q@28211,4BR2Z@82117,COG1596@1,COG1596@2	NA|NA|NA	M	Polysaccharide biosynthesis/export protein
MAG.T21.41_04161	864069.MicloDRAFT_00011920	1.1e-37	163.3	Methylobacteriaceae				ko:K07497					ko00000				Bacteria	1JUUR@119045,1MVN5@1224,2TQK0@28211,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
MAG.T21.41_04162	195105.CN97_03405	1.1e-142	512.7	Alphaproteobacteria													Bacteria	1MVTF@1224,2TT3Z@28211,COG0739@1,COG0739@2	NA|NA|NA	M	COG0739 Membrane proteins related to metalloendopeptidases
MAG.T21.41_04163	195105.CN97_03400	8.4e-68	263.1	Alphaproteobacteria													Bacteria	1MZ9V@1224,2UC0B@28211,COG3019@1,COG3019@2	NA|NA|NA	S	metal-binding protein
MAG.T21.41_04164	330214.NIDE1353	9.1e-156	556.6	Nitrospirae	aroB		2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	3J0GA@40117,COG0337@1,COG0337@2	NA|NA|NA	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MAG.T21.41_04165	330214.NIDE1354	2.7e-214	751.1	Nitrospirae			4.2.1.75,4.6.1.1	ko:K01719,ko:K01768,ko:K02584	ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213	M00121,M00695	R00089,R00434,R03165	RC00295,RC01861	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	3J0XQ@40117,COG2203@1,COG2203@2,COG3605@1,COG3605@2	NA|NA|NA	T	ANTAR
MAG.T21.41_04167	330214.NIDE1931	4.1e-201	707.2	Nitrospirae	fdsB		1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	3J0WX@40117,COG1894@1,COG1894@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
MAG.T21.41_04168	1280952.HJA_03946	3.1e-41	175.3	Alphaproteobacteria	mobA		2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100		R11581		ko00000,ko00001,ko01000				Bacteria	1RH3M@1224,2TV2G@28211,COG0746@1,COG0746@2	NA|NA|NA	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MAG.T21.41_04169	228405.HNE_1567	8.9e-105	386.3	Hyphomonadaceae	can		4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000			iNJ661.Rv3273	Bacteria	1NGFN@1224,2TRPD@28211,43XGX@69657,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide
MAG.T21.41_04170	1280953.HOC_17801	7.4e-63	246.9	Hyphomonadaceae													Bacteria	1RKE4@1224,2U9WK@28211,43ZSK@69657,COG2846@1,COG2846@2	NA|NA|NA	D	Hemerythrin HHE cation binding domain
MAG.T21.41_04171	228405.HNE_1565	1.9e-29	135.6	Hyphomonadaceae	nifM		2.3.1.39,5.2.1.8	ko:K00645,ko:K02597,ko:K03769,ko:K03771	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko03110				Bacteria	1RDD3@1224,2U3I3@28211,4400E@69657,COG0760@1,COG0760@2	NA|NA|NA	O	peptidylprolyl
MAG.T21.41_04172	330214.NIDE3966	1.5e-240	838.6	Bacteria	cvaA												Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_04173	330214.NIDE3965	9.5e-79	299.7	Nitrospirae	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	Bacteria	3J0P8@40117,COG0041@1,COG0041@2	NA|NA|NA	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MAG.T21.41_04174	330214.NIDE3964	5.9e-179	633.6	Nitrospirae	purK	GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477	Bacteria	3J11N@40117,COG0026@1,COG0026@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MAG.T21.41_04175	330214.NIDE3963	1.8e-275	954.9	Nitrospirae													Bacteria	3J10H@40117,COG0784@1,COG0784@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04176	330214.NIDE3962	1.7e-112	412.1	Nitrospirae													Bacteria	3J16E@40117,COG0705@1,COG0705@2	NA|NA|NA	S	Rhomboid family
MAG.T21.41_04177	330214.NIDE3961	1.5e-147	528.9	Nitrospirae	nrnB			ko:K07097					ko00000				Bacteria	3J12M@40117,COG2404@1,COG2404@2	NA|NA|NA	S	hydrolase activity, acting on ester bonds
MAG.T21.41_04178	330214.NIDE3960	3.8e-185	654.1	Nitrospirae	fas6		3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	3J169@40117,COG1611@1,COG1611@2	NA|NA|NA	S	Possible lysine decarboxylase
MAG.T21.41_04179	330214.NIDE3959	1.2e-130	472.6	Bacteria			1.1.1.42,1.3.1.85	ko:K00031,ko:K14446	ko00020,ko00480,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00373,M00740	R00267,R00268,R01899,R09291	RC00001,RC00084,RC00114,RC00626,RC02481,RC02801	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG2905@1,COG2905@2	NA|NA|NA	T	signal-transduction protein containing cAMP-binding and CBS domains
MAG.T21.41_04180	330214.NIDE3958	9.9e-195	686.4	Nitrospirae	BP2925			ko:K09930					ko00000				Bacteria	3J130@40117,COG3220@1,COG3220@2	NA|NA|NA	S	Protein of unknown function (DUF692)
MAG.T21.41_04181	330214.NIDE3957	2.8e-189	667.9	Bacteria	dus			ko:K05541					ko00000,ko01000,ko03016				Bacteria	COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MAG.T21.41_04182	330214.NIDE3956	2.1e-77	295.4	Bacteria	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	2.1.1.190	ko:K03215,ko:K06287					ko00000,ko01000,ko03009				Bacteria	COG0424@1,COG0424@2	NA|NA|NA	D	maF-like protein
MAG.T21.41_04184	426355.Mrad2831_2561	2.3e-113	416.0	Methylobacteriaceae													Bacteria	1JXGR@119045,1QX4P@1224,2V8VU@28211,COG2931@1,COG2931@2	NA|NA|NA	Q	calcium- and calmodulin-responsive adenylate cyclase activity
MAG.T21.41_04185	330214.NIDE3953	1.3e-171	609.0	Bacteria	pdhA		1.2.4.1,1.2.4.4	ko:K00161,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG1071@1,COG1071@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAG.T21.41_04186	330214.NIDE3952	2e-164	585.1	Bacteria	pdhB		1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2753	Bacteria	COG0022@1,COG0022@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAG.T21.41_04187	330214.NIDE3951	5.1e-178	630.6	Bacteria	pdhC		1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	COG0508@1,COG0508@2	NA|NA|NA	C	S-acyltransferase activity
MAG.T21.41_04188	330214.NIDE3950	2.9e-160	571.2	Nitrospirae	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100		R07767,R07768	RC01978	ko00000,ko00001,ko01000				Bacteria	3J0IY@40117,COG0320@1,COG0320@2	NA|NA|NA	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MAG.T21.41_04189	1123256.KB907925_gene1399	4e-75	288.5	Xanthomonadales	kch		3.6.1.22	ko:K03426,ko:K10716	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	1MXQP@1224,1SWIH@1236,1XAQW@135614,COG1226@1,COG1226@2	NA|NA|NA	P	Ion channel
MAG.T21.41_04190	330214.NIDE3947	4.8e-247	860.5	Bacteria	mscM												Bacteria	COG0668@1,COG0668@2	NA|NA|NA	M	transmembrane transport
MAG.T21.41_04191	330214.NIDE3944	1.9e-204	718.4	Nitrospirae	salY			ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	3J0EW@40117,COG0577@1,COG0577@2	NA|NA|NA	V	MacB-like periplasmic core domain
MAG.T21.41_04192	330214.NIDE3943	5.5e-163	580.5	Nitrospirae	macA_1			ko:K02005,ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Bacteria	3J0HQ@40117,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_04193	330214.NIDE3676	2.3e-79	301.6	Bacteria													Bacteria	2DBP7@1,2ZA82@2	NA|NA|NA		
MAG.T21.41_04194	330214.NIDE3675	5.6e-125	453.8	Bacteria													Bacteria	2DKWD@1,30KRK@2	NA|NA|NA		
MAG.T21.41_04197	330214.NIDE1789	1.6e-19	102.4	Bacteria													Bacteria	COG3293@1,COG3293@2	NA|NA|NA	L	Transposase
MAG.T21.41_04198	29581.BW37_01210	7e-36	158.7	Oxalobacteraceae				ko:K07001					ko00000				Bacteria	1MUI6@1224,2WDK7@28216,4786Z@75682,COG1752@1,COG1752@2	NA|NA|NA	S	Patatin-like phospholipase
MAG.T21.41_04201	1463917.JODC01000028_gene932	2.5e-08	66.6	Actinobacteria													Bacteria	2DBJW@1,2IDBS@201174,2Z9P2@2	NA|NA|NA		
MAG.T21.41_04202	861299.J421_5702	1.9e-33	149.8	Gemmatimonadetes													Bacteria	1ZTKN@142182,COG4454@1,COG4454@2	NA|NA|NA		
MAG.T21.41_04204	330214.NIDE3664	1.4e-35	155.6	Nitrospirae				ko:K07088					ko00000				Bacteria	3J1EB@40117,COG0679@1,COG0679@2	NA|NA|NA	S	Membrane transport protein
MAG.T21.41_04205	330214.NIDE2644	1.8e-218	765.0	Nitrospirae			2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	3J0DH@40117,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MAG.T21.41_04206	330214.NIDE2643	3.8e-180	637.5	Nitrospirae	lptG			ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1			Bacteria	3J0QQ@40117,COG0795@1,COG0795@2	NA|NA|NA	S	Predicted permease YjgP/YjgQ family
MAG.T21.41_04207	330214.NIDE2642	2.1e-186	658.3	Nitrospirae	lptF			ko:K07091,ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1			Bacteria	3J0S0@40117,COG0795@1,COG0795@2	NA|NA|NA	S	Predicted permease YjgP/YjgQ family
MAG.T21.41_04208	330214.NIDE2641	2.4e-33	147.5	Nitrospirae	cspA			ko:K03704					ko00000,ko03000				Bacteria	3J0QZ@40117,COG1278@1,COG1278@2	NA|NA|NA	K	'Cold-shock' DNA-binding domain
MAG.T21.41_04209	269799.Gmet_1635	8.5e-26	125.6	Desulfuromonadales													Bacteria	1NSRW@1224,2WTZ6@28221,42YBG@68525,43TDF@69541,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T21.41_04210	330214.NIDE2639	3.3e-146	524.6	Nitrospirae			1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120		R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000				Bacteria	3J13M@40117,COG1052@1,COG1052@2	NA|NA|NA	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
MAG.T21.41_04211	330214.NIDE2638	0.0	1617.1	Nitrospirae	dld			ko:K18930					ko00000				Bacteria	3J0ZS@40117,COG0247@1,COG0247@2,COG0277@1,COG0277@2	NA|NA|NA	C	FAD linked oxidases, C-terminal domain
MAG.T21.41_04214	330214.NIDE2635	2.5e-175	621.3	Bacteria				ko:K13572					ko00000,ko03051				Bacteria	COG2378@1,COG2378@2	NA|NA|NA	K	regulation of single-species biofilm formation
MAG.T21.41_04215	330214.NIDE1569	3.1e-171	608.2	Bacteria				ko:K03309					ko00000	2.A.23			Bacteria	COG1301@1,COG1301@2	NA|NA|NA	C	dicarboxylic acid transport
MAG.T21.41_04216	330214.NIDE1570	2.8e-184	651.4	Bacteria			3.4.24.40	ko:K01406	ko01503,map01503				ko00000,ko00001,ko01000,ko01002				Bacteria	COG3391@1,COG3391@2	NA|NA|NA	CO	amine dehydrogenase activity
MAG.T21.41_04217	330214.NIDE2630	0.0	1111.7	Bacteria	M1-852		3.4.21.107	ko:K01173,ko:K04771	ko01503,ko02020,ko04210,map01503,map02020,map04210	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03029,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T21.41_04218	765698.Mesci_3450	1.4e-108	399.4	Phyllobacteriaceae	ydeK												Bacteria	1MVHN@1224,2TRCU@28211,43IDT@69277,COG0697@1,COG0697@2	NA|NA|NA	EG	transporter
MAG.T21.41_04219	1298858.AUEL01000009_gene4227	1.6e-111	409.5	Phyllobacteriaceae	norG												Bacteria	1MV6F@1224,2TQP9@28211,43I0Z@69277,COG1167@1,COG1167@2	NA|NA|NA	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MAG.T21.41_04220	344747.PM8797T_28259	2.3e-268	932.2	Planctomycetes													Bacteria	2IWV8@203682,COG1112@1,COG1112@2,COG2251@1,COG2251@2	NA|NA|NA	L	AAA domain
MAG.T21.41_04222	330214.NIDE3570	3e-69	270.0	Nitrospirae			2.7.13.3	ko:K11527					ko00000,ko01000,ko01001,ko02022				Bacteria	3J10H@40117,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04224	1123389.ATXJ01000028_gene897	2.8e-21	107.8	Deinococcus-Thermus				ko:K07075					ko00000				Bacteria	1WKPG@1297,COG1669@1,COG1669@2	NA|NA|NA	S	Nucleotidyltransferase domain
MAG.T21.41_04226	330214.NIDE1672	1.7e-68	265.4	Bacteria													Bacteria	COG1396@1,COG1396@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T21.41_04227	330214.NIDE1671	1.1e-281	975.7	Bacteria	oliA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085											Bacteria	COG1297@1,COG1297@2	NA|NA|NA	S	iron-nicotianamine transmembrane transporter activity
MAG.T21.41_04228	330214.NIDE1670	3.8e-197	694.1	Nitrospirae	rlmI		2.1.1.191,2.1.1.72	ko:K00571,ko:K06969					ko00000,ko01000,ko02048,ko03009				Bacteria	3J0IV@40117,COG1092@1,COG1092@2	NA|NA|NA	J	S-adenosylmethionine-dependent methyltransferase
MAG.T21.41_04229	330214.NIDE1669	1.4e-295	1021.5	Bacteria	ipdC		4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100		R01974	RC00506	ko00000,ko00001,ko01000				Bacteria	COG3961@1,COG3961@2	NA|NA|NA	GH	pyruvate decarboxylase activity
MAG.T21.41_04232	330214.NIDE1666	5e-229	800.0	Bacteria	gpgS		2.4.1.266	ko:K13693					ko00000,ko01000,ko01003		GT81		Bacteria	COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T21.41_04234	404380.Gbem_0061	2.2e-52	212.6	Proteobacteria													Bacteria	1RA9F@1224,2DMNF@1,32SNT@2	NA|NA|NA	S	FRG
MAG.T21.41_04236	330214.NIDE3307	7.2e-148	530.0	Bacteria	crtF	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.210,2.1.1.304,2.1.1.333	ko:K09846,ko:K13604,ko:K21460	ko00860,ko00906,ko01100,ko01110,map00860,map00906,map01100,map01110		R07521,R07524,R07527,R07529,R07533,R07535,R09063	RC00003,RC01662,RC02082	ko00000,ko00001,ko01000				Bacteria	COG2813@1,COG2813@2	NA|NA|NA	J	rRNA (guanine-N2-)-methyltransferase activity
MAG.T21.41_04237	330214.NIDE3306	8.5e-120	436.4	Bacteria				ko:K08976					ko00000				Bacteria	COG2322@1,COG2322@2	NA|NA|NA	S	membrane
MAG.T21.41_04241	330214.NIDE2563	3.9e-117	427.6	Nitrospirae	radC			ko:K03630					ko00000				Bacteria	3J0HV@40117,COG2003@1,COG2003@2	NA|NA|NA	E	RadC-like JAB domain
MAG.T21.41_04242	330214.NIDE2562	0.0	1079.3	Nitrospirae	fusA2			ko:K02355					ko00000,ko03012,ko03029				Bacteria	3J0WU@40117,COG0480@1,COG0480@2	NA|NA|NA	J	Elongation factor G, domain IV
MAG.T21.41_04243	330214.NIDE2561	8.2e-228	796.2	Bacteria			3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T21.41_04244	330214.NIDE2560	1.9e-86	325.5	Bacteria				ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	COG0569@1,COG0569@2	NA|NA|NA	P	domain protein
MAG.T21.41_04245	1217720.ALOX01000014_gene2357	2e-68	266.2	Rhodospirillales				ko:K12993					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	1RJJU@1224,2JYM3@204441,2VF2C@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_04246	1205680.CAKO01000004_gene3662	2.3e-51	209.9	Rhodospirillales				ko:K20999	ko02025,map02025				ko00000,ko00001,ko01003		GT4		Bacteria	1PNUD@1224,2JXZI@204441,2V1DD@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T21.41_04247	1205680.CAKO01000004_gene3663	1.4e-63	250.0	Proteobacteria													Bacteria	1NFE9@1224,2AZMH@1,31RW8@2	NA|NA|NA		
MAG.T21.41_04248	330214.NIDE3044	0.0	1457.6	Nitrospirae	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K07277					ko00000,ko02000,ko03029	1.B.33			Bacteria	3J0AC@40117,COG4775@1,COG4775@2	NA|NA|NA	M	Surface antigen
MAG.T21.41_04249	330214.NIDE3043	4.3e-58	231.1	Nitrospirae	ompH			ko:K06142					ko00000				Bacteria	3J1AH@40117,COG2825@1,COG2825@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04250	330214.NIDE3042	6.9e-66	256.9	Nitrospirae	ompH			ko:K06142					ko00000				Bacteria	3J1AH@40117,COG2825@1,COG2825@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04251	330214.NIDE3041	3.1e-75	287.7	Nitrospirae	fabZ	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171	3.5.1.108,4.2.1.59	ko:K02372,ko:K16363	ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212	M00060,M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005				Bacteria	3J0NG@40117,COG0764@1,COG0764@2	NA|NA|NA	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MAG.T21.41_04252	330214.NIDE3040	5.8e-117	427.2	Nitrospirae	lpxA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005			iIT341.HP1375,iPC815.YPO1056	Bacteria	3J0G6@40117,COG1043@1,COG1043@2	NA|NA|NA	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MAG.T21.41_04253	330214.NIDE3039	6.2e-138	496.9	Nitrospirae	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748,ko:K09949	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT19		Bacteria	3J0KP@40117,COG3494@1,COG3494@2	NA|NA|NA	S	Protein of unknown function (DUF1009)
MAG.T21.41_04254	330214.NIDE3038	5.2e-152	543.9	Nitrospirae	gnnA			ko:K09949					ko00000			iAF987.Gmet_2352	Bacteria	3J0M7@40117,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, NAD-binding Rossmann fold
MAG.T21.41_04255	330214.NIDE3037	1.5e-187	662.1	Nitrospirae	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478,iIT341.HP0867	Bacteria	3J0MA@40117,COG0763@1,COG0763@2	NA|NA|NA	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MAG.T21.41_04256	330214.NIDE3036	4.8e-294	1016.5	Nitrospirae	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02021,ko:K06147,ko:K11085	ko02010,map02010				ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21		iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	Bacteria	3J0X8@40117,COG1132@1,COG1132@2	NA|NA|NA	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_04257	330214.NIDE3034	3.1e-15	87.4	Bacteria	MA20_05800		2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527,ko:K09778	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT30		Bacteria	COG2121@1,COG2121@2	NA|NA|NA	S	Domain of unknown function (DUF374)
MAG.T21.41_04258	330214.NIDE3033	9e-187	659.8	Nitrospirae	kdtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT30	iECNA114_1301.ECNA114_3778,iIT341.HP0957,iUMNK88_1353.UMNK88_4417	Bacteria	3J0J7@40117,COG1519@1,COG1519@2	NA|NA|NA	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)
MAG.T21.41_04260	330214.NIDE0666	1.4e-204	718.8	Bacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG0577@1,COG0577@2	NA|NA|NA	V	efflux transmembrane transporter activity
MAG.T21.41_04261	330214.NIDE0667	1e-202	712.6	Bacteria				ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	COG0577@1,COG0577@2	NA|NA|NA	V	efflux transmembrane transporter activity
MAG.T21.41_04263	228410.NE0559	5.9e-162	578.2	Nitrosomonadales				ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1QTT0@1224,2WGP0@28216,374M9@32003,COG4773@1,COG4773@2	NA|NA|NA	P	InterPro IPR000531 COGs COG1629
MAG.T21.41_04264	335283.Neut_1727	3e-125	455.3	Nitrosomonadales													Bacteria	1MXGY@1224,2VKZZ@28216,373ZG@32003,COG3182@1,COG3182@2	NA|NA|NA	S	PepSY-associated TM region
MAG.T21.41_04265	330214.NIDE0669	3.3e-31	140.6	Bacteria													Bacteria	COG2452@1,COG2452@2	NA|NA|NA	L	recombinase activity
MAG.T21.41_04266	330214.NIDE0670	6.3e-75	287.0	Bacteria													Bacteria	2BVVW@1,32175@2	NA|NA|NA	S	Cytochrome P460
MAG.T21.41_04272	330214.NIDE0676	8.5e-75	286.6	Nitrospirae	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802		ko:K07285					ko00000				Bacteria	3J1BB@40117,COG3065@1,COG3065@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04273	330214.NIDE0677	5.8e-104	383.6	Bacteria	dsbA	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096		ko:K03673	ko01503,map01503	M00728			ko00000,ko00001,ko00002,ko03110			iEcSMS35_1347.EcSMS35_4241	Bacteria	COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAG.T21.41_04274	330214.NIDE0678	0.0	1487.6	Nitrospirae	pacS	GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	3J0CY@40117,COG2217@1,COG2217@2	NA|NA|NA	P	E1-E2 ATPase
MAG.T21.41_04275	330214.NIDE0681	1.9e-243	848.2	Nitrospirae	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	3J0X9@40117,COG0265@1,COG0265@2	NA|NA|NA	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_04278	330214.NIDE0685	5e-55	221.1	Bacteria				ko:K02456,ko:K02650,ko:K02679,ko:K08084	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
MAG.T21.41_04279	330214.NIDE0686	0.0	1250.7	Nitrospirae													Bacteria	3J10H@40117,COG0784@1,COG0784@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04280	330214.NIDE0687	3.6e-149	534.6	Nitrospirae				ko:K07814					ko00000,ko02022				Bacteria	3J0ID@40117,COG3437@1,COG3437@2	NA|NA|NA	T	response regulator
MAG.T21.41_04281	330214.NIDE0688	7e-66	256.5	Bacteria	nikR	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K07722					ko00000,ko03000				Bacteria	COG0864@1,COG0864@2	NA|NA|NA	K	response to nickel cation
MAG.T21.41_04282	330214.NIDE0689	3.2e-50	204.5	Nitrospirae													Bacteria	2AIN5@1,3194H@2,3J1DR@40117	NA|NA|NA	S	Domain of unknown function (DUF3842)
MAG.T21.41_04283	330214.NIDE0690	0.0	1184.9	Bacteria													Bacteria	COG4772@1,COG4772@2	NA|NA|NA	P	TonB-dependent receptor
MAG.T21.41_04284	504728.K649_12140	6.3e-150	537.0	Deinococcus-Thermus	dys		2.5.1.46	ko:K00809					ko00000,ko01000				Bacteria	1WI9Q@1297,COG1899@1,COG1899@2	NA|NA|NA	O	Deoxyhypusine synthase
MAG.T21.41_04285	379066.GAU_3200	2.7e-93	348.6	Gemmatimonadetes	hldD		5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1ZUKD@142182,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
MAG.T21.41_04286	330214.NIDE0691	1.8e-67	262.3	Bacteria	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	COG2094@1,COG2094@2	NA|NA|NA	L	Belongs to the DNA glycosylase MPG family
MAG.T21.41_04289	330214.NIDE0694	0.0	1091.6	Nitrospirae			2.7.13.3	ko:K02482					ko00000,ko01000,ko01001,ko02022				Bacteria	3J117@40117,COG2203@1,COG2203@2,COG4191@1,COG4191@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T21.41_04292	1121271.AUCM01000016_gene2631	4.5e-92	344.0	Alphaproteobacteria													Bacteria	1MVYT@1224,2TUXV@28211,COG1376@1,COG1376@2	NA|NA|NA	S	ErfK YbiS YcfS YnhG family protein
MAG.T21.41_04294	1121271.AUCM01000016_gene2630	7.4e-95	353.2	Alphaproteobacteria													Bacteria	1MVYT@1224,2U60K@28211,COG1376@1,COG1376@2	NA|NA|NA	S	ErfK YbiS YcfS YnhG family protein
MAG.T21.41_04295	195105.CN97_03315	1.7e-94	352.4	Alphaproteobacteria	dsbA												Bacteria	1N0SP@1224,2UCCV@28211,COG1651@1,COG1651@2	NA|NA|NA	O	Thioredoxin
MAG.T21.41_04297	330214.NIDE1185	0.0	2023.8	Nitrospirae	aas		2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564		R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000				Bacteria	3J17I@40117,COG0204@1,COG0204@2,COG0318@1,COG0318@2,COG0477@1,COG2814@2	NA|NA|NA	I	Phosphate acyltransferases
MAG.T21.41_04298	330214.NIDE1186	5.1e-278	963.4	Bacteria	mutS			ko:K03555	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	COG0249@1,COG0249@2	NA|NA|NA	L	mismatched DNA binding
MAG.T21.41_04299	330214.NIDE1187	4.6e-103	380.9	Nitrospirae	prmA			ko:K02687					ko00000,ko01000,ko03009				Bacteria	3J1B7@40117,COG2264@1,COG2264@2	NA|NA|NA	J	Ribosomal protein L11 methyltransferase (PrmA)
MAG.T21.41_04300	1446473.JHWH01000003_gene3144	3.7e-100	370.9	Paracoccus													Bacteria	1R0GC@1224,28JTG@1,2PZ6G@265,2TWC3@28211,2Z9IR@2	NA|NA|NA	S	Protein of unknown function (DUF2793)
MAG.T21.41_04301	290512.Paes_0636	5.6e-22	111.3	Bacteria			3.6.1.17	ko:K01518	ko00230,ko00240,map00230,map00240		R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000				Bacteria	COG0537@1,COG0537@2	NA|NA|NA	FG	bis(5'-adenosyl)-triphosphatase activity
MAG.T21.41_04302	1280953.HOC_10824	5.2e-43	181.0	Bacteria			3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0717@1,COG0717@2	NA|NA|NA	F	dUTP biosynthetic process
MAG.T21.41_04303	1280953.HOC_10829	2.5e-16	92.4	Bacteria													Bacteria	2BZB5@1,2ZGCI@2	NA|NA|NA		
MAG.T21.41_04304	1280953.HOC_10834	9.6e-82	310.8	Proteobacteria	ycbJ												Bacteria	1P34T@1224,COG3173@1,COG3173@2	NA|NA|NA	S	Aminoglycoside phosphotransferase
MAG.T21.41_04305	1280953.HOC_10839	8.9e-84	317.4	Bacteria	thiL		2.7.4.16	ko:K00946,ko:K07123	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iYO844.BSU05900	Bacteria	COG0611@1,COG0611@2	NA|NA|NA	H	thiamine-phosphate kinase activity
MAG.T21.41_04306	1280953.HOC_10844	3.1e-52	211.8	Proteobacteria	ymaB												Bacteria	1RG92@1224,COG4112@1,COG4112@2	NA|NA|NA		
MAG.T21.41_04308	330214.NIDE2459	6.6e-253	879.8	Nitrospirae	hflX			ko:K03665					ko00000,ko03009				Bacteria	3J0AE@40117,COG2262@1,COG2262@2	NA|NA|NA	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MAG.T21.41_04309	330214.NIDE2458	1.7e-156	558.9	Nitrospirae	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	3J0I3@40117,COG0533@1,COG0533@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MAG.T21.41_04310	330214.NIDE2457	2.1e-277	961.1	Nitrospirae	clpC			ko:K03696	ko01100,map01100				ko00000,ko03110				Bacteria	3J0B4@40117,COG0542@1,COG0542@2	NA|NA|NA	O	C-terminal, D2-small domain, of ClpB protein
MAG.T21.41_04311	395494.Galf_2037	2.5e-13	81.3	Betaproteobacteria				ko:K07733					ko00000,ko03000				Bacteria	1NHVW@1224,2VYCF@28216,COG3311@1,COG3311@2	NA|NA|NA	K	Transcriptional regulator
MAG.T21.41_04312	626418.bglu_1g12080	1.5e-20	105.9	Burkholderiaceae				ko:K07483					ko00000				Bacteria	1KI2D@119060,1N7SX@1224,2WFHU@28216,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
MAG.T21.41_04313	857087.Metme_1978	2.8e-44	184.5	Methylococcales													Bacteria	1MZFT@1224,1SABV@1236,1XGY3@135618,COG3436@1,COG3436@2	NA|NA|NA	L	IS66 Orf2 like protein
MAG.T21.41_04314	857087.Metme_1149	3.5e-211	741.1	Methylococcales				ko:K07484					ko00000				Bacteria	1RHKZ@1224,1S7XK@1236,1XH1V@135618,COG3316@1,COG3316@2	NA|NA|NA	L	IS66 C-terminal element
MAG.T21.41_04315	330214.NIDE3715	5.5e-34	150.2	Nitrospirae	cutA			ko:K03926					ko00000				Bacteria	3J0UM@40117,COG1324@1,COG1324@2	NA|NA|NA	P	CutA1 divalent ion tolerance protein
MAG.T21.41_04316	330214.NIDE3717	3.1e-50	204.1	Nitrospirae	pspE												Bacteria	3J17U@40117,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T21.41_04317	330214.NIDE3718	2.2e-165	588.2	Nitrospirae	galE1	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000				Bacteria	3J12G@40117,COG0451@1,COG0451@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
MAG.T21.41_04318	330214.NIDE3719	3.6e-114	417.9	Nitrospirae	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442					ko00000,ko01000,ko03009				Bacteria	3J0MD@40117,COG1189@1,COG1189@2	NA|NA|NA	J	FtsJ-like methyltransferase
MAG.T21.41_04319	330214.NIDE3720	7.1e-34	149.4	Bacteria	xseB		3.1.11.6	ko:K03602	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	COG1722@1,COG1722@2	NA|NA|NA	L	exodeoxyribonuclease VII activity
MAG.T21.41_04320	330214.NIDE3721	4.4e-186	657.5	Nitrospirae	xseA		3.1.11.6,3.4.21.102	ko:K03601,ko:K03797	ko03430,map03430				ko00000,ko00001,ko01000,ko01002,ko03400				Bacteria	3J0S9@40117,COG1570@1,COG1570@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MAG.T21.41_04321	330214.NIDE3722	1.2e-138	499.2	Nitrospirae	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578		ko:K02029,ko:K02030,ko:K09769		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	3J0JW@40117,COG1692@1,COG1692@2	NA|NA|NA	S	YmdB-like protein
MAG.T21.41_04322	330214.NIDE3723	2.4e-239	834.7	Nitrospirae	rny			ko:K05802,ko:K18682	ko03018,map03018				ko00000,ko00001,ko01000,ko02000,ko03019	1.A.23.1.1			Bacteria	3J0C8@40117,COG1418@1,COG1418@2,COG4372@1,COG4372@2	NA|NA|NA	S	Endoribonuclease that initiates mRNA decay
MAG.T21.41_04324	330214.NIDE3725	1.1e-39	169.1	Bacteria	zapA			ko:K09888					ko00000,ko03036				Bacteria	COG3027@1,COG3027@2	NA|NA|NA	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MAG.T21.41_04326	330214.NIDE3727	0.0	1194.5	Nitrospirae	slt			ko:K05807,ko:K08309					ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23		Bacteria	3J0VD@40117,COG0457@1,COG0457@2,COG0741@1,COG0741@2,COG1729@1,COG1729@2	NA|NA|NA	M	Transglycosylase SLT domain
MAG.T21.41_04327	330214.NIDE3728	9.9e-176	622.9	Nitrospirae	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Bacteria	3J0CH@40117,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MAG.T21.41_04328	330214.NIDE3729	3.5e-231	807.4	Nitrospirae				ko:K07263					ko00000,ko01000,ko01002				Bacteria	3J0BY@40117,COG0612@1,COG0612@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04329	330214.NIDE3730	4.2e-226	790.4	Nitrospirae				ko:K07263					ko00000,ko01000,ko01002				Bacteria	3J0I5@40117,COG0612@1,COG0612@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04330	330214.NIDE3731	6.1e-114	417.2	Bacteria	larE		4.99.1.12	ko:K06864,ko:K09121					ko00000,ko01000				Bacteria	COG1606@1,COG1606@2	NA|NA|NA	L	tRNA processing
MAG.T21.41_04331	330214.NIDE3732	1.3e-50	206.1	Nitrospirae	atpF			ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	3J1AE@40117,COG0711@1,COG0711@2	NA|NA|NA	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAG.T21.41_04332	330214.NIDE3733	9.5e-25	119.0	Nitrospirae	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159			ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3			Bacteria	3J198@40117,COG0636@1,COG0636@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T21.41_04333	330214.NIDE3734	3.7e-126	457.6	Nitrospirae	atpB			ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1			Bacteria	3J0RW@40117,COG0356@1,COG0356@2	NA|NA|NA	C	it plays a direct role in the translocation of protons across the membrane
MAG.T21.41_04334	330214.NIDE3735	3.6e-39	167.2	Bacteria	atpI			ko:K02116					ko00000,ko00194	3.A.2.1			Bacteria	COG5336@1,COG5336@2	NA|NA|NA	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
MAG.T21.41_04335	330214.NIDE3736	6.9e-209	733.4	Nitrospirae	pabB	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01665	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000				Bacteria	3J0FG@40117,COG0147@1,COG0147@2	NA|NA|NA	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MAG.T21.41_04336	330214.NIDE3737	3e-138	498.0	Nitrospirae	pabC		2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	3J0BM@40117,COG0115@1,COG0115@2	NA|NA|NA	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAG.T21.41_04337	330214.NIDE3738	8.7e-95	353.2	Nitrospirae													Bacteria	3J19T@40117,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
MAG.T21.41_04338	330214.NIDE3739	1.1e-287	995.3	Nitrospirae	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000			iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899	Bacteria	3J0DI@40117,COG0029@1,COG0029@2	NA|NA|NA	H	FAD binding domain
MAG.T21.41_04341	330214.NIDE3743	1e-304	1052.0	Nitrospirae	msbA2			ko:K06147,ko:K11085	ko02010,map02010				ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	3J0X8@40117,COG1132@1,COG1132@2	NA|NA|NA	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_04342	330214.NIDE3744	3.9e-127	461.1	Nitrospirae			3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152				ko00000,ko00001,ko01000				Bacteria	3J186@40117,COG3511@1,COG3511@2	NA|NA|NA	M	Phosphoesterase family
MAG.T21.41_04343	330214.NIDE3745	0.0	1380.5	Nitrospirae	yloB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.8	ko:K01537					ko00000,ko01000	3.A.3.2		iYO844.BSU15650	Bacteria	3J0YX@40117,COG0474@1,COG0474@2	NA|NA|NA	P	Cation transporter/ATPase, N-terminus
MAG.T21.41_04344	330214.NIDE3747	2.8e-68	264.6	Bacteria													Bacteria	2CIIF@1,315FB@2	NA|NA|NA		
MAG.T21.41_04347	1340493.JNIF01000003_gene3716	1e-11	77.8	Acidobacteria				ko:K21010	ko02025,map02025				ko00000,ko00001				Bacteria	3Y8U1@57723,COG4783@1,COG4783@2	NA|NA|NA	S	chaperone-mediated protein folding
MAG.T21.41_04349	330214.NIDE3752	1.1e-149	536.2	Bacteria	yrbG			ko:K07301					ko00000,ko02000	2.A.19.5			Bacteria	COG0530@1,COG0530@2	NA|NA|NA	P	calcium, potassium:sodium antiporter activity
MAG.T21.41_04350	330214.NIDE3753	7.5e-243	846.3	Nitrospirae													Bacteria	3J10H@40117,COG0745@1,COG0745@2,COG4191@1,COG4191@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04351	330214.NIDE3754	0.0	1228.8	Nitrospirae	mgtA		3.6.3.2	ko:K01531					ko00000,ko01000	3.A.3.4			Bacteria	3J0WH@40117,COG0474@1,COG0474@2	NA|NA|NA	P	Cation transporter/ATPase, N-terminus
MAG.T21.41_04352	330214.NIDE3755	5.5e-148	530.4	Bacteria				ko:K15726					ko00000,ko02000	2.A.6.1.2			Bacteria	COG3696@1,COG3696@2	NA|NA|NA	P	silver ion transport
MAG.T21.41_04353	330214.NIDE4096	1.3e-58	232.6	Bacteria													Bacteria	COG4970@1,COG4970@2	NA|NA|NA	NU	protein transport across the cell outer membrane
MAG.T21.41_04354	330214.NIDE4095	4.5e-62	244.2	Bacteria	ppdC			ko:K02671,ko:K02681,ko:K10927	ko05111,map05111				ko00000,ko00001,ko02035,ko02044				Bacteria	COG4967@1,COG4967@2	NA|NA|NA	NU	type IV pilus modification protein PilV
MAG.T21.41_04355	330214.NIDE4094	2.1e-162	578.6	Bacteria				ko:K02672					ko00000,ko02035,ko02044				Bacteria	COG4966@1,COG4966@2	NA|NA|NA	NU	pilus assembly protein PilW
MAG.T21.41_04359	1003200.AXXA_27950	3.4e-21	110.5	Bacteria			3.2.1.15	ko:K01184,ko:K12548	ko00040,ko01100,map00040,map01100	M00081	R01982,R02360	RC00049	ko00000,ko00001,ko00002,ko01000				Bacteria	COG5434@1,COG5434@2	NA|NA|NA	M	polygalacturonase activity
MAG.T21.41_04361	216142.LT40_08970	1.2e-35	156.4	Gammaproteobacteria			3.2.1.17	ko:K01185					ko00000,ko01000				Bacteria	1MZJD@1224,1S99W@1236,COG3772@1,COG3772@2	NA|NA|NA	G	lysozyme
MAG.T21.41_04363	794903.OPIT5_28465	3.3e-18	99.0	Bacteria													Bacteria	28QEN@1,2ZCWY@2	NA|NA|NA		
MAG.T21.41_04364	330214.NIDE3331	9.5e-28	129.0	Bacteria				ko:K02078					ko00000,ko00001				Bacteria	COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAG.T21.41_04365	330214.NIDE3330	4.5e-177	627.9	Bacteria	fapR												Bacteria	COG1028@1,COG1028@2,COG2030@1,COG2030@2	NA|NA|NA	I	dehydratase
MAG.T21.41_04366	330214.NIDE3329	2.7e-296	1024.2	Bacteria													Bacteria	COG3882@1,COG3882@2	NA|NA|NA	Q	phosphopantetheine binding
MAG.T21.41_04367	330214.NIDE3328	3.4e-70	271.6	Bacteria	cysE		2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1045@1,COG1045@2	NA|NA|NA	E	serine acetyltransferase
MAG.T21.41_04368	330214.NIDE3327	2.9e-48	197.6	Bacteria	rbpA												Bacteria	COG0724@1,COG0724@2	NA|NA|NA	K	RNA recognition motif
MAG.T21.41_04369	1205680.CAKO01000002_gene2136	4.7e-25	121.7	Alphaproteobacteria			2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	1R7DS@1224,2U3SK@28211,COG3848@1,COG3848@2	NA|NA|NA	T	Pyruvate phosphate dikinase
MAG.T21.41_04370	1379281.AVAG01000028_gene128	1.1e-27	128.6	Deltaproteobacteria													Bacteria	1NPTZ@1224,2WWUI@28221,431E8@68525,COG1598@1,COG1598@2	NA|NA|NA	S	PFAM Uncharacterised protein family UPF0150
MAG.T21.41_04371	1278073.MYSTI_01650	1.4e-25	122.9	Myxococcales	yafP		5.3.1.16	ko:K01814,ko:K03830,ko:K07146	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000				Bacteria	1QX9F@1224,2WTE1@28221,2Z0P8@29,42XG7@68525,COG0454@1,COG0454@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
MAG.T21.41_04372	1121382.JQKG01000001_gene2226	2.3e-60	239.2	Bacteria													Bacteria	COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase
MAG.T21.41_04373	91464.S7335_888	2.1e-66	259.2	Cyanobacteria													Bacteria	1GET1@1117,2CFXT@1,2ZAIF@2	NA|NA|NA	S	Streptomycin adenylyltransferase
MAG.T21.41_04374	756883.Halar_2532	1.3e-07	63.2	Archaea													Archaea	COG5378@1,arCOG02121@2157	NA|NA|NA	S	PFAM Nucleotide-binding protein, PIN domain
MAG.T21.41_04377	1000565.METUNv1_03477	1.6e-27	129.0	Rhodocyclales													Bacteria	1MZ7P@1224,2DM6D@1,2KYYM@206389,2VUHB@28216,31WQ8@2	NA|NA|NA		
MAG.T21.41_04378	330214.NIDE4348	1.9e-107	395.2	Nitrospirae	leuD	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01704,ko:K01705	ko00290,ko00300,ko00660,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R10170	RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J10U@40117,COG0066@1,COG0066@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T21.41_04379	330214.NIDE4347	8.4e-265	919.1	Nitrospirae	leuC		4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	3J0IH@40117,COG0065@1,COG0065@2	NA|NA|NA	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T21.41_04382	330214.NIDE4343	2.5e-65	255.0	Bacteria													Bacteria	2C3ZQ@1,32SCF@2	NA|NA|NA	S	MEKHLA domain
MAG.T21.41_04383	330214.NIDE4342	5.7e-27	126.3	Bacteria				ko:K09705					ko00000				Bacteria	COG4728@1,COG4728@2	NA|NA|NA	FJ	Protein conserved in bacteria
MAG.T21.41_04384	330214.NIDE4341	6.8e-222	776.5	Nitrospirae	pdhD		1.16.1.1,1.8.1.4	ko:K00382,ko:K00520	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	3J11P@40117,COG1249@1,COG1249@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
MAG.T21.41_04388	330214.NIDE4337	4.6e-138	497.3	Bacteria													Bacteria	COG0668@1,COG0668@2	NA|NA|NA	M	transmembrane transport
MAG.T21.41_04390	330214.NIDE4335	3.1e-144	517.7	Nitrospirae	xthA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2	ko:K01142	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	3J13K@40117,COG0708@1,COG0708@2	NA|NA|NA	L	Endonuclease/Exonuclease/phosphatase family
MAG.T21.41_04395	330214.NIDE4332	2.5e-93	348.2	Bacteria	lemA			ko:K03744					ko00000				Bacteria	COG1704@1,COG1704@2	NA|NA|NA	S	LemA family
MAG.T21.41_04396	330214.NIDE4331	3.7e-96	358.2	Bacteria				ko:K06872					ko00000				Bacteria	COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
MAG.T21.41_04397	330214.NIDE4330	9e-84	316.6	Bacteria				ko:K08988					ko00000				Bacteria	COG3762@1,COG3762@2	NA|NA|NA	S	Membrane
MAG.T21.41_04398	330214.NIDE4329	4.4e-265	920.2	Nitrospirae	murJ			ko:K03980					ko00000,ko01011,ko02000	2.A.66.4			Bacteria	3J0CQ@40117,COG0728@1,COG0728@2	NA|NA|NA	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
MAG.T21.41_04399	330214.NIDE4328	2e-59	235.3	Nitrospirae	ogt		2.1.1.63	ko:K00567,ko:K10778,ko:K13531					ko00000,ko01000,ko03000,ko03400				Bacteria	3J1A8@40117,COG0350@1,COG0350@2	NA|NA|NA	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MAG.T21.41_04400	330214.NIDE4327	1.2e-60	239.2	Nitrospirae	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K07560					ko00000,ko01000,ko03016				Bacteria	3J149@40117,COG1490@1,COG1490@2	NA|NA|NA	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MAG.T21.41_04401	330214.NIDE4326	3.2e-98	364.4	Bacteria													Bacteria	2CK1C@1,32SJA@2	NA|NA|NA		
MAG.T21.41_04402	330214.NIDE4324	5.5e-132	477.2	Nitrospirae	aspG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	3.4.19.5,3.5.1.1,3.5.1.26	ko:K01424,ko:K01444,ko:K13051	ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142		R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002				Bacteria	3J19S@40117,COG1446@1,COG1446@2	NA|NA|NA	E	Asparaginase
MAG.T21.41_04403	330214.NIDE4323	7.2e-58	229.9	Bacteria				ko:K06991					ko00000				Bacteria	COG3565@1,COG3565@2	NA|NA|NA	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MAG.T21.41_04404	330214.NIDE4322	8.3e-121	439.9	Nitrospirae	mtgA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	3J127@40117,COG0744@1,COG0744@2	NA|NA|NA	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAG.T21.41_04405	330214.NIDE4321	3.3e-101	374.4	Nitrospirae	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03978					ko00000,ko03036				Bacteria	3J1D5@40117,COG0218@1,COG0218@2	NA|NA|NA	D	Necessary for normal cell division and for the maintenance of normal septation
MAG.T21.41_04406	330214.NIDE4320	1.1e-141	509.6	Nitrospirae	surA		5.2.1.8	ko:K02597,ko:K03769,ko:K03771					ko00000,ko01000,ko03110				Bacteria	3J0SR@40117,COG0760@1,COG0760@2	NA|NA|NA	O	SurA N-terminal domain
MAG.T21.41_04407	330214.NIDE4319	9.2e-140	503.1	Nitrospirae	prsA		3.1.3.16,5.2.1.8	ko:K01802,ko:K03769,ko:K07533,ko:K20074					ko00000,ko01000,ko01009,ko03110				Bacteria	3J16U@40117,COG0760@1,COG0760@2	NA|NA|NA	O	PPIC-type PPIASE domain
MAG.T21.41_04408	330214.NIDE4318	0.0	2155.9	Nitrospirae	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03723	ko03420,map03420				ko00000,ko00001,ko01000,ko03400				Bacteria	3J0BA@40117,COG1197@1,COG1197@2	NA|NA|NA	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MAG.T21.41_04409	330214.NIDE4317	4.4e-72	277.3	Nitrospirae	aut		2.7.1.167,2.7.7.70	ko:K03272,ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0JP@40117,COG0615@1,COG0615@2	NA|NA|NA	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MAG.T21.41_04410	330214.NIDE4316	2.8e-184	651.4	Bacteria	dinB	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346					ko00000,ko01000,ko03400				Bacteria	COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAG.T21.41_04411	330214.NIDE4315	1e-76	293.1	Bacteria	sprT			ko:K02742					ko00000				Bacteria	COG3091@1,COG3091@2	NA|NA|NA	K	SprT-like family
MAG.T21.41_04412	330214.NIDE4314	2.2e-166	591.7	Bacteria													Bacteria	COG1899@1,COG1899@2	NA|NA|NA	O	peptidyl-lysine modification to peptidyl-hypusine
MAG.T21.41_04413	330214.NIDE4313	5.4e-93	347.1	Nitrospirae	gmhA		5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3J0HG@40117,COG0279@1,COG0279@2	NA|NA|NA	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate
MAG.T21.41_04415	330214.NIDE4312	9.6e-140	503.1	Nitrospirae	qmcA												Bacteria	3J0NF@40117,COG0330@1,COG0330@2	NA|NA|NA	O	prohibitin homologues
MAG.T21.41_04416	330214.NIDE4311	8.9e-64	249.6	Bacteria				ko:K07340					ko00000				Bacteria	COG1585@1,COG1585@2	NA|NA|NA	OU	cellular response to DNA damage stimulus
MAG.T21.41_04417	1125863.JAFN01000001_gene3192	6.4e-30	138.7	Deltaproteobacteria													Bacteria	1R4YZ@1224,2WNS2@28221,42S9R@68525,COG0457@1,COG0457@2	NA|NA|NA	S	CRISPR-associated protein (Cas_Cas02710)
MAG.T21.41_04419	371731.Rsw2DRAFT_2071	1.1e-133	483.0	Alphaproteobacteria	virB6			ko:K03201	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1QJY1@1224,2TSZ1@28211,COG3704@1,COG3704@2	NA|NA|NA	U	COG3704 Type IV secretory pathway, VirB6 components
MAG.T21.41_04421	371731.Rsw2DRAFT_2069	7.7e-122	443.4	Alphaproteobacteria													Bacteria	1MVU9@1224,2TRV4@28211,COG1256@1,COG1256@2	NA|NA|NA	N	Conjugal transfer protein TraF
MAG.T21.41_04422	330214.NIDE4076	3e-39	167.5	Bacteria	truB		1.9.3.1,2.7.7.13,3.2.1.97,5.4.99.25	ko:K00412,ko:K00971,ko:K02275,ko:K02389,ko:K03177,ko:K17624	ko00051,ko00190,ko00520,ko01100,ko01110,ko02020,ko02040,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00051,map00190,map00520,map01100,map01110,map02020,map02040,map04260,map04714,map04932,map05010,map05012,map05016	M00114,M00151,M00152,M00155,M00361,M00362	R00081,R00885	RC00002,RC00016	ko00000,ko00001,ko00002,ko01000,ko02035,ko03016,ko03029	3.D.4.2,3.D.4.4,3.D.4.6	GH101		Bacteria	COG1565@1,COG1565@2	NA|NA|NA	P	acr, cog1565
MAG.T21.41_04424	330214.NIDE4075	3.8e-31	140.6	Nitrospirae	tatA			ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	3J1A4@40117,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MAG.T21.41_04425	330214.NIDE4074	1.1e-25	122.5	Bacteria	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	COG1826@1,COG1826@2	NA|NA|NA	U	protein secretion
MAG.T21.41_04426	330214.NIDE4073	2.5e-308	1063.9	Bacteria	VPA1441												Bacteria	COG3203@1,COG3203@2	NA|NA|NA	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MAG.T21.41_04428	330214.NIDE4071	1.8e-286	991.5	Bacteria			3.6.4.12	ko:K03654	ko03018,map03018				ko00000,ko00001,ko01000,ko03400				Bacteria	COG0514@1,COG0514@2	NA|NA|NA	L	ATP-dependent DNA helicase (RecQ)
MAG.T21.41_04429	330214.NIDE4070	1e-105	389.4	Bacteria	thrH		2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0560@1,COG0560@2	NA|NA|NA	E	Phosphoserine phosphatase
MAG.T21.41_04430	330214.NIDE4069	3.1e-110	404.8	Bacteria													Bacteria	COG0727@1,COG0727@2	NA|NA|NA	S	metal cluster binding
MAG.T21.41_04432	330214.NIDE4067	5.3e-110	404.1	Nitrospirae													Bacteria	3J1BM@40117,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
MAG.T21.41_04433	330214.NIDE4066	2.7e-69	268.1	Bacteria	MA20_25125												Bacteria	COG2947@1,COG2947@2	NA|NA|NA	L	Ubiquinol--cytochrome c reductase
MAG.T21.41_04435	330214.NIDE4064	1.2e-119	436.0	Nitrospirae	yaaT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464											Bacteria	3J0MI@40117,COG1774@1,COG1774@2	NA|NA|NA	S	PSP1 C-terminal conserved region
MAG.T21.41_04436	330214.NIDE4063	8.8e-177	626.3	Bacteria	lysDH		1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1748@1,COG1748@2	NA|NA|NA	E	saccharopine dehydrogenase activity
MAG.T21.41_04439	398527.Bphyt_3727	1.7e-70	273.1	Burkholderiaceae													Bacteria	1KBVI@119060,1RDUQ@1224,28IFP@1,2W4ND@28216,2Z8HD@2	NA|NA|NA	S	Protein of unknown function (DUF3644)
MAG.T21.41_04440	1231057.AMGD01000054_gene75	1.2e-12	80.9	Bacilli													Bacteria	1VZCM@1239,2FFXX@1,347UU@2,4HZ6X@91061	NA|NA|NA	S	RES domain
MAG.T21.41_04441	536019.Mesop_4983	1.8e-37	162.5	Phyllobacteriaceae													Bacteria	1PRVY@1224,2ADG6@1,2UWH5@28211,3136A@2,43QKD@69277	NA|NA|NA		
MAG.T21.41_04442	879310.HMPREF9162_0465	1.1e-07	62.8	Negativicutes													Bacteria	1UKEF@1239,4H60C@909932,COG3620@1,COG3620@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T21.41_04443	657322.FPR_09250	6.8e-14	83.6	Ruminococcaceae		GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360											Bacteria	1VB8K@1239,24KV8@186801,3WM39@541000,COG4679@1,COG4679@2	NA|NA|NA	S	Phage derived protein Gp49-like (DUF891)
MAG.T21.41_04445	330214.NIDE1873	0.0	1456.8	Bacteria													Bacteria	COG2982@1,COG2982@2	NA|NA|NA	M	Protein involved in outer membrane biogenesis
MAG.T21.41_04446	330214.NIDE1874	2.3e-20	105.1	Bacteria													Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
MAG.T21.41_04447	330214.NIDE1875	1.3e-119	435.6	Nitrospirae	lsfA		1.11.1.15	ko:K03386,ko:K03665	ko04214,map04214				ko00000,ko00001,ko01000,ko03009,ko04147				Bacteria	3J0T1@40117,COG0450@1,COG0450@2	NA|NA|NA	O	C-terminal domain of 1-Cys peroxiredoxin
MAG.T21.41_04448	330214.NIDE1878	0.0	1201.8	Bacteria													Bacteria	COG1032@1,COG1032@2	NA|NA|NA	C	radical SAM domain protein
MAG.T21.41_04449	330214.NIDE1879	4.5e-183	647.5	Bacteria													Bacteria	COG2206@1,COG2206@2	NA|NA|NA	T	PFAM metal-dependent phosphohydrolase, HD sub domain
MAG.T21.41_04450	330214.NIDE1881	1.5e-119	436.0	Nitrospirae	mtnW		4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000				Bacteria	3J16S@40117,COG1850@1,COG1850@2	NA|NA|NA	G	Ribulose bisphosphate carboxylase large chain, catalytic domain
MAG.T21.41_04451	330214.NIDE3591	0.0	1232.2	Nitrospirae	mrcB		2.4.1.129,3.4.16.4	ko:K03814,ko:K05365	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	3J1FP@40117,COG0744@1,COG0744@2	NA|NA|NA	M	Transglycosylase
MAG.T21.41_04453	330214.NIDE3112	6.1e-108	397.1	Bacteria	pyrE		2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000				Bacteria	COG0461@1,COG0461@2	NA|NA|NA	F	orotate phosphoribosyltransferase activity
MAG.T21.41_04454	330214.NIDE3111	9.9e-151	539.7	Nitrospirae													Bacteria	3J1AP@40117,COG0179@1,COG0179@2	NA|NA|NA	Q	Fumarylacetoacetate (FAA) hydrolase family
MAG.T21.41_04455	330214.NIDE3110	2.4e-174	618.2	Bacteria	hmgA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000				Bacteria	COG3508@1,COG3508@2	NA|NA|NA	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MAG.T21.41_04456	330214.NIDE3109	1.1e-93	349.4	Bacteria			5.1.99.1	ko:K05606,ko:K17315	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko02010,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map02010	M00373,M00375,M00376,M00605,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.24,3.A.1.1.30			Bacteria	COG3185@1,COG3185@2	NA|NA|NA	E	4-Hydroxyphenylpyruvate dioxygenase
MAG.T21.41_04457	330214.NIDE3106	1.9e-98	365.5	Bacteria			1.3.3.11	ko:K06137					ko00000,ko01000				Bacteria	COG5424@1,COG5424@2	NA|NA|NA	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
MAG.T21.41_04458	330214.NIDE3105	1.4e-261	908.7	Nitrospirae			6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	3J12Y@40117,COG0318@1,COG0318@2	NA|NA|NA	IQ	AMP-binding enzyme C-terminal domain
MAG.T21.41_04459	330214.NIDE3104	3.9e-194	684.1	Bacteria	thlA		2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T21.41_04460	330214.NIDE3103	7e-183	646.7	Nitrospirae	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K00074,ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200,ic_1306.c2886	Bacteria	3J1F9@40117,COG1250@1,COG1250@2	NA|NA|NA	C	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
MAG.T21.41_04462	330214.NIDE3102	1.1e-109	402.9	Nitrospirae	fadB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01715,ko:K13767	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000				Bacteria	3J1EP@40117,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase/isomerase
MAG.T21.41_04463	330214.NIDE3101	3.7e-176	624.4	Bacteria				ko:K07001					ko00000				Bacteria	COG1752@1,COG1752@2	NA|NA|NA	M	Esterase of the alpha-beta hydrolase superfamily
MAG.T21.41_04464	330214.NIDE3100	4.3e-251	874.0	Nitrospirae	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Bacteria	3J13U@40117,COG1960@1,COG1960@2	NA|NA|NA	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04465	330214.NIDE3099	7e-163	580.1	Bacteria													Bacteria	2DQ6K@1,334ZA@2	NA|NA|NA		
MAG.T21.41_04466	880073.Calab_3483	2.1e-14	84.3	unclassified Bacteria	tnaA		4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000				Bacteria	2NNZV@2323,COG3033@1,COG3033@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T21.41_04467	869210.Marky_1642	1.4e-21	108.6	Deinococcus-Thermus	tnaA		4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000				Bacteria	1WM62@1297,COG3033@1,COG3033@2	NA|NA|NA	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase
MAG.T21.41_04468	880073.Calab_3483	2.9e-40	171.4	unclassified Bacteria	tnaA		4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000				Bacteria	2NNZV@2323,COG3033@1,COG3033@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T21.41_04469	880073.Calab_3483	2e-21	108.6	unclassified Bacteria	tnaA		4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000				Bacteria	2NNZV@2323,COG3033@1,COG3033@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T21.41_04470	1191523.MROS_0698	2e-08	64.7	Bacteria	tnaA		4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000				Bacteria	COG3033@1,COG3033@2	NA|NA|NA	E	tryptophanase activity
MAG.T21.41_04471	330214.NIDE3098	7.3e-293	1012.7	Bacteria													Bacteria	COG2831@1,COG2831@2	NA|NA|NA	U	hemolysin activation secretion protein
MAG.T21.41_04472	330214.NIDE3097	3.5e-193	681.0	Bacteria													Bacteria	COG3210@1,COG3210@2	NA|NA|NA	U	domain, Protein
MAG.T21.41_04473	330214.NIDE3096	0.0	1163.3	Bacteria													Bacteria	COG0457@1,COG0457@2,COG4995@1,COG4995@2	NA|NA|NA	S	CHAT domain
MAG.T21.41_04474	330214.NIDE3095	1.8e-90	339.0	Bacteria													Bacteria	COG1750@1,COG1750@2	NA|NA|NA		
MAG.T21.41_04475	330214.NIDE3094	2.2e-114	418.7	Bacteria													Bacteria	COG4221@1,COG4221@2	NA|NA|NA	IQ	oxidoreductase activity
MAG.T21.41_04476	330214.NIDE3093	5.9e-62	243.4	Nitrospirae													Bacteria	3J1FA@40117,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
MAG.T21.41_04477	330214.NIDE3092	0.0	1718.4	Nitrospirae			2.7.13.3	ko:K07675	ko02020,map02020	M00473			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	3J12P@40117,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2	NA|NA|NA	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04478	330214.NIDE3091	1.4e-110	405.6	Nitrospirae	vsrD2			ko:K02282,ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475			ko00000,ko00001,ko00002,ko02022,ko02035,ko02044				Bacteria	3J12Q@40117,COG2197@1,COG2197@2	NA|NA|NA	K	Product type r regulator
MAG.T21.41_04481	330214.NIDE3088	5.8e-197	693.7	Nitrospirae	atoC			ko:K02481					ko00000,ko02022				Bacteria	3J107@40117,COG2204@1,COG2204@2	NA|NA|NA	T	Bacterial regulatory protein, Fis family
MAG.T21.41_04482	330214.NIDE3087	7.7e-84	316.6	Bacteria	ycbK			ko:K02395					ko00000,ko02035				Bacteria	COG3108@1,COG3108@2	NA|NA|NA	S	Peptidase M15
MAG.T21.41_04487	330214.NIDE3081	4.7e-131	473.8	Bacteria													Bacteria	COG3253@1,COG3253@2	NA|NA|NA	S	peroxidase activity
MAG.T21.41_04489	330214.NIDE3079	1.1e-191	676.0	Nitrospirae	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019159,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	3J1AS@40117,COG1058@1,COG1058@2,COG1546@1,COG1546@2	NA|NA|NA	S	Competence-damaged protein
MAG.T21.41_04490	330214.NIDE3078	3.5e-66	258.1	Nitrospirae	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975					ko00000,ko01000,ko03016				Bacteria	3J1B8@40117,COG1514@1,COG1514@2	NA|NA|NA	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MAG.T21.41_04492	330214.NIDE1705	2.4e-190	671.4	Nitrospirae	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Bacteria	3J0C1@40117,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MAG.T21.41_04493	330214.NIDE1706	5.7e-55	220.3	Bacteria	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496	2.4.1.337	ko:K03565,ko:K19002	ko00561,ko01100,map00561,map01100		R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03400		GT4		Bacteria	COG2137@1,COG2137@2	NA|NA|NA	S	regulation of DNA repair
MAG.T21.41_04494	330214.NIDE1707	0.0	1637.9	Nitrospirae	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	Bacteria	3J0D3@40117,COG0013@1,COG0013@2	NA|NA|NA	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MAG.T21.41_04495	330214.NIDE1708	1.4e-83	315.8	Nitrospirae	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07447					ko00000,ko01000				Bacteria	3J1AR@40117,COG0816@1,COG0816@2	NA|NA|NA	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MAG.T21.41_04496	330214.NIDE1801	4.2e-145	520.8	Bacteria	potD			ko:K11069,ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1		iSB619.SA_RS05395	Bacteria	COG0687@1,COG0687@2	NA|NA|NA	E	Required for the activity of the bacterial periplasmic transport system of putrescine
MAG.T21.41_04497	330214.NIDE1802	6.4e-209	733.4	Nitrospirae	czcC			ko:K15725					ko00000,ko02000	1.B.17.2.2			Bacteria	3J1F2@40117,COG1538@1,COG1538@2	NA|NA|NA	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T21.41_04498	330214.NIDE1803	3.3e-174	617.8	Bacteria				ko:K15727					ko00000,ko02000	8.A.1.2.1			Bacteria	COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAG.T21.41_04502	330214.NIDE2362	2.6e-83	314.7	Nitrospirae	cheW	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009893,GO:0009987,GO:0010604,GO:0016020,GO:0019222,GO:0019904,GO:0023052,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032991,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098561,GO:1901873,GO:1901875		ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	3J0PG@40117,COG0835@1,COG0835@2	NA|NA|NA	NT	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_04503	330214.NIDE2361	0.0	1124.8	Nitrospirae	cheA	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0019904,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	3J0BG@40117,COG0643@1,COG0643@2,COG2198@1,COG2198@2	NA|NA|NA	NT	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T21.41_04504	330214.NIDE2360	2.5e-59	234.6	Nitrospirae													Bacteria	3J18A@40117,COG0745@1,COG0745@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T21.41_04505	330214.NIDE2359	8.2e-146	523.5	Bacteria				ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	COG0840@1,COG0840@2	NA|NA|NA	NT	transmembrane signaling receptor activity
MAG.T21.41_04507	330214.NIDE2357	7.3e-133	479.9	Nitrospirae	motB			ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	3J0MN@40117,COG1360@1,COG1360@2	NA|NA|NA	N	Membrane MotB of proton-channel complex MotA/MotB
MAG.T21.41_04508	330214.NIDE2356	1.4e-102	379.0	Nitrospirae	motC			ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	3J0KF@40117,COG1291@1,COG1291@2	NA|NA|NA	N	MotA/TolQ/ExbB proton channel family
MAG.T21.41_04509	1485545.JQLW01000009_gene90	3.2e-39	169.1	Proteobacteria													Bacteria	1MXGW@1224,COG3765@1,COG3765@2	NA|NA|NA	M	lipopolysaccharide biosynthesis protein
MAG.T21.41_04510	326427.Cagg_1965	1.6e-07	64.3	Chloroflexia													Bacteria	2GB1Q@200795,377RC@32061,COG2244@1,COG2244@2	NA|NA|NA	S	PFAM polysaccharide biosynthesis protein
MAG.T21.41_04511	1205680.CAKO01000007_gene4400	6.4e-49	200.3	Alphaproteobacteria													Bacteria	1N6NJ@1224,2DMY4@1,2UES2@28211,32UCB@2	NA|NA|NA	S	Tripartite tricarboxylate transporter TctB family
MAG.T21.41_04513	935840.JAEQ01000006_gene2617	6e-110	403.7	Phyllobacteriaceae													Bacteria	1MVN5@1224,2TQK0@28211,43IUV@69277,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
MAG.T21.41_04514	1500301.JQMF01000023_gene5574	3.1e-112	411.8	Rhizobiaceae			3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Bacteria	1MUJH@1224,2TSB8@28211,4BC06@82115,COG3119@1,COG3119@2	NA|NA|NA	P	Sulfatase
MAG.T21.41_04515	717785.HYPMC_1730	2.3e-54	218.8	Alphaproteobacteria			1.8.1.9	ko:K00384,ko:K01420,ko:K10914,ko:K21561	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000				Bacteria	1Q70G@1224,2UC77@28211,COG0664@1,COG0664@2	NA|NA|NA	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MAG.T21.41_04516	1235457.C404_04265	1.8e-10	72.8	Burkholderiaceae				ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	1K8H3@119060,1RG5V@1224,2VS3W@28216,COG0664@1,COG0664@2	NA|NA|NA	K	Crp-like helix-turn-helix domain
MAG.T21.41_04517	1042326.AZNV01000030_gene3628	5.9e-48	198.4	Alphaproteobacteria													Bacteria	1MVK1@1224,2U2SR@28211,COG5403@1,COG5403@2	NA|NA|NA	S	PFAM Bacterial protein of
MAG.T21.41_04518	1207075.PputUW4_02816	3e-38	164.9	Gammaproteobacteria													Bacteria	1NX2A@1224,1SM5A@1236,COG5361@1,COG5361@2	NA|NA|NA	S	Protein of unknown function (DUF1254)
MAG.T21.41_04519	666684.AfiDRAFT_1115	4e-38	164.1	Bradyrhizobiaceae	cadC		1.20.4.1	ko:K03741,ko:K03892					ko00000,ko01000,ko03000				Bacteria	1MZAU@1224,2U9NV@28211,3JZQ9@41294,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T21.41_04522	1415780.JPOG01000001_gene2866	8.7e-20	104.8	Xanthomonadales				ko:K18481,ko:K18640		M00670			ko00000,ko00002,ko02000,ko04812	3.A.1.27.4,3.A.1.27.5			Bacteria	1P7BK@1224,1RRN2@1236,1X4Q7@135614,COG0443@1,COG0443@2	NA|NA|NA	O	PRTRC system protein D
MAG.T21.41_04524	1449126.JQKL01000069_gene3628	8.7e-10	70.5	Clostridia	ydjM	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K07038					ko00000				Bacteria	1V3QT@1239,24WWI@186801,COG1988@1,COG1988@2	NA|NA|NA	S	LexA-binding, inner membrane-associated putative hydrolase
MAG.T21.41_04525	1121396.KB892905_gene4209	1.9e-08	65.5	Desulfobacterales													Bacteria	1P545@1224,2BX7T@1,2MP44@213118,2WXAH@28221,2ZFES@2,433ME@68525	NA|NA|NA		
MAG.T21.41_04527	877418.ATWV01000006_gene2069	2.2e-15	88.6	Spirochaetes	smf			ko:K04096					ko00000				Bacteria	2JAX3@203691,COG0758@1,COG0758@2	NA|NA|NA	LU	Protein of unknown function (DUF2493)
MAG.T21.41_04529	521045.Kole_1767	5.7e-19	101.7	Bacteria				ko:K06993					ko00000				Bacteria	COG3341@1,COG3341@2	NA|NA|NA	L	Caulimovirus viroplasmin
# 3410 queries scanned
# Total time (seconds): 5.67722702026
# Rate: 600.65 q/s