# emapper version: emapper-2.0.1 emapper DB: 2.0
# command: ./emapper.py  -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T22.39/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/Bin_prokka//MAG.T22.39/MAG.T22.39.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share2/Bin_all/emapper//MAG.T22.39/MAG.T22.39 --usemem --override
# time: Wed Feb 25 23:47:16 2026
#query_name	seed_eggNOG_ortholog	seed_ortholog_evalue	seed_ortholog_score	best_tax_level	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	taxonomic scope	eggNOG OGs	best eggNOG OG	COG Functional cat.	eggNOG free text desc.
MAG.T22.39_00001	680646.RMDY18_05350	2.4e-49	202.6	Actinobacteria													Bacteria	29SM8@1,2H3BM@201174,30DSN@2	NA|NA|NA		
MAG.T22.39_00002	1306174.JODP01000006_gene3620	1.5e-41	175.3	Actinobacteria	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077		ko:K04078					ko00000,ko03029,ko03110				Bacteria	2IKTH@201174,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MAG.T22.39_00003	1146883.BLASA_4244	2e-117	429.1	Frankiales	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	2GJ98@201174,4ERH6@85013,COG0533@1,COG0533@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MAG.T22.39_00004	367299.JOEE01000007_gene133	3.6e-31	141.4	Intrasporangiaceae	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128,2.3.1.234	ko:K01409,ko:K03789,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03009,ko03016				Bacteria	2IM9R@201174,4FGQ5@85021,COG0454@1,COG0456@2	NA|NA|NA	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MAG.T22.39_00005	463191.SSEG_08653	7.1e-29	134.4	Actinobacteria	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03016				Bacteria	2GMTM@201174,COG1214@1,COG1214@2	NA|NA|NA	O	PFAM Peptidase M22, glycoprotease
MAG.T22.39_00006	526225.Gobs_4459	2.4e-24	118.6	Frankiales	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.1.221,5.1.1.1	ko:K01775,ko:K06925,ko:K07102	ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502		R00401,R08968,R11024	RC00002,RC00078,RC00285	ko00000,ko00001,ko01000,ko01011,ko03016				Bacteria	2IKV2@201174,4ESZ5@85013,COG0802@1,COG0802@2	NA|NA|NA	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T22.39_00007	1120950.KB892784_gene194	3.6e-66	258.8	Propionibacteriales													Bacteria	2GMCK@201174,4DNK4@85009,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T22.39_00008	1463936.JOJI01000014_gene6956	6.8e-92	344.4	Actinobacteria	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502		R00401	RC00285	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440	Bacteria	2GM2Y@201174,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAG.T22.39_00009	1380356.JNIK01000018_gene603	1.9e-86	326.6	Frankiales	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759					ko00000,ko01000				Bacteria	2GJHB@201174,4ERGP@85013,COG0062@1,COG0062@2,COG0063@1,COG0063@2	NA|NA|NA	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MAG.T22.39_00010	1003195.SCAT_3631	1.9e-256	891.7	Actinobacteria	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002			iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780	Bacteria	2GKH0@201174,COG0449@1,COG0449@2	NA|NA|NA	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MAG.T22.39_00011	2045.KR76_15450	1.6e-76	293.1	Propionibacteriales													Bacteria	2GJQ4@201174,4DN08@85009,COG1808@1,COG1808@2	NA|NA|NA	S	Domain of unknown function (DUF389)
MAG.T22.39_00012	1120950.KB892784_gene183	1.2e-164	586.3	Propionibacteriales	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130		R02060	RC00408	ko00000,ko00001,ko01000			iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206	Bacteria	2GN87@201174,4DNFP@85009,COG1109@1,COG1109@2	NA|NA|NA	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAG.T22.39_00013	396014.BF93_14630	9.5e-54	216.5	Dermabacteraceae	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02996	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GNDY@201174,4FC2W@85020,COG0103@1,COG0103@2	NA|NA|NA	J	Ribosomal protein S9/S16
MAG.T22.39_00014	1385521.N803_03265	9.4e-61	239.6	Intrasporangiaceae	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02871	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFG1@201174,4FGEI@85021,COG0102@1,COG0102@2	NA|NA|NA	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MAG.T22.39_00016	700508.D174_06475	7.3e-18	96.7	Mycobacteriaceae				ko:K06995					ko00000				Bacteria	23AJY@1762,2IHPC@201174,COG3450@1,COG3450@2	NA|NA|NA	S	Protein of unknown function (DUF861)
MAG.T22.39_00017	68570.DC74_3794	2.8e-71	275.4	Actinobacteria	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173					ko00000,ko01000,ko03016				Bacteria	2GJ6C@201174,COG0101@1,COG0101@2	NA|NA|NA	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MAG.T22.39_00018	471853.Bcav_3112	7.5e-53	213.8	Actinobacteria	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904		ko:K02879	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHV2@201174,COG0203@1,COG0203@2	NA|NA|NA	J	ribosomal protein L17
MAG.T22.39_00019	1380354.JIAN01000009_gene3655	0.0	1266.9	Cellulomonadaceae	narG		1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1			Bacteria	2GKZU@201174,4F0MY@85016,COG5013@1,COG5013@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MAG.T22.39_00020	2055.JNXA01000013_gene2737	1.4e-239	835.5	Gordoniaceae	narH		1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1			Bacteria	2GJ8P@201174,4GBH6@85026,COG1140@1,COG1140@2	NA|NA|NA	C	Respiratory nitrate reductase beta C-terminal
MAG.T22.39_00021	1146883.BLASA_4871	1e-47	196.8	Frankiales	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373,ko:K17052	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687	Bacteria	2IAQV@201174,4ESU6@85013,COG2180@1,COG2180@2	NA|NA|NA	C	Nitrate reductase, delta subunit
MAG.T22.39_00022	1123024.AUII01000046_gene3925	4.4e-87	327.8	Pseudonocardiales	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1		iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Bacteria	2GJVI@201174,4E0F4@85010,COG2181@1,COG2181@2	NA|NA|NA	C	Nitrate reductase gamma subunit
MAG.T22.39_00023	1385520.N802_16610	9.4e-131	473.4	Actinobacteria													Bacteria	2GMDQ@201174,COG4861@1,COG4861@2	NA|NA|NA	S	Protein conserved in bacteria
MAG.T22.39_00024	1385520.N802_16605	5e-55	221.1	Actinobacteria													Bacteria	2AN1K@1,2I8YS@201174,31CYZ@2	NA|NA|NA		
MAG.T22.39_00025	469383.Cwoe_0906	3.6e-16	93.2	Actinobacteria													Bacteria	2IGGC@201174,COG3568@1,COG3568@2	NA|NA|NA	S	Endonuclease/Exonuclease/phosphatase family
MAG.T22.39_00028	479432.Sros_2797	4.2e-150	538.1	Streptosporangiales				ko:K03294					ko00000	2.A.3.2			Bacteria	2GJ75@201174,4EFKE@85012,COG0531@1,COG0531@2	NA|NA|NA	E	C-terminus of AA_permease
MAG.T22.39_00029	1123320.KB889730_gene5887	3.2e-44	185.7	Actinobacteria	uspA4	GO:0008150,GO:0040007											Bacteria	2I8XM@201174,COG0589@1,COG0589@2	NA|NA|NA	T	universal stress protein
MAG.T22.39_00030	1207075.PputUW4_02040	7.9e-10	70.9	Proteobacteria													Bacteria	1N77Y@1224,2E3UG@1,32YRU@2	NA|NA|NA	S	Domain of unknown function (DUF4287)
MAG.T22.39_00031	1454010.JEOE01000011_gene2396	3.7e-75	289.7	Actinobacteria													Bacteria	2IBWT@201174,COG4425@1,COG4425@2	NA|NA|NA	S	Alpha/beta-hydrolase family
MAG.T22.39_00032	1223543.GP2_021_00600	2.2e-14	85.1	Gordoniaceae													Bacteria	2I5BR@201174,4GGWE@85026,COG4405@1,COG4405@2	NA|NA|NA	S	Pfam:DUF385
MAG.T22.39_00033	138119.DSY1012	1.1e-306	1058.9	Peptococcaceae	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110		R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000				Bacteria	1TQDA@1239,24DM7@186801,260RF@186807,COG0376@1,COG0376@2	NA|NA|NA	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MAG.T22.39_00034	926550.CLDAP_32510	9.2e-46	189.9	Chloroflexi	furA			ko:K03711,ko:K22297					ko00000,ko03000				Bacteria	2G9HJ@200795,COG0735@1,COG0735@2	NA|NA|NA	P	Ferric uptake regulator family
MAG.T22.39_00035	1121272.KB903259_gene6552	2.7e-45	188.7	Micromonosporales				ko:K07100					ko00000				Bacteria	2GJUU@201174,4DC71@85008,COG1926@1,COG1926@2	NA|NA|NA	S	Phosphoribosyl transferase domain
MAG.T22.39_00036	1210046.B277_01084	9.4e-13	79.3	Actinobacteria													Bacteria	2B44R@1,2GXZ7@201174,31WV8@2	NA|NA|NA	S	Superinfection immunity protein
MAG.T22.39_00038	585531.HMPREF0063_11706	1.4e-47	196.8	Propionibacteriales	ribD		1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN2P@201174,4DRKD@85009,COG1985@1,COG1985@2	NA|NA|NA	H	RibD C-terminal domain
MAG.T22.39_00041	1236902.ANAS01000012_gene813	1.5e-09	68.6	Streptosporangiales													Bacteria	2DR18@1,2I6ZB@201174,339RQ@2,4EKVG@85012	NA|NA|NA		
MAG.T22.39_00042	1122182.KB903815_gene1434	1.1e-63	250.8	Micromonosporales	moaA2		2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2	NA|NA|NA	H	Probable molybdopterin binding domain
MAG.T22.39_00043	196162.Noca_2927	9.4e-32	142.9	Actinobacteria				ko:K03892					ko00000,ko03000				Bacteria	2IKPW@201174,COG0640@1,COG0640@2	NA|NA|NA	K	Transcriptional regulator, arsR family
MAG.T22.39_00044	710696.Intca_2823	3.5e-128	464.9	Actinobacteria	yrkH												Bacteria	2GNS6@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2	NA|NA|NA	P	PFAM Metallo-beta-lactamase superfamily
MAG.T22.39_00045	1429046.RR21198_5341	1.7e-55	222.2	Nocardiaceae													Bacteria	2HGHZ@201174,4FXJI@85025,COG2210@1,COG2210@2	NA|NA|NA	S	DsrE/DsrF/DrsH-like family
MAG.T22.39_00046	101510.RHA1_ro11227	5.6e-17	93.2	Nocardiaceae													Bacteria	2HICA@201174,4G3Q7@85025,COG0425@1,COG0425@2	NA|NA|NA	O	Belongs to the sulfur carrier protein TusA family
MAG.T22.39_00047	710696.Intca_2820	1.8e-169	602.4	Intrasporangiaceae	ttrC			ko:K08359	ko00920,ko01120,ko02020,map00920,map01120,map02020		R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10			Bacteria	2I2DV@201174,4FF0K@85021,COG0437@1,COG0437@2,COG3301@1,COG3301@2	NA|NA|NA	C	4Fe-4S dicluster domain
MAG.T22.39_00048	101510.RHA1_ro11225	0.0	1467.2	Nocardiaceae	psrA												Bacteria	2GNYQ@201174,4G030@85025,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MAG.T22.39_00049	1394178.AWOO02000004_gene2358	8.4e-65	254.2	Streptosporangiales				ko:K02529					ko00000,ko03000				Bacteria	2GK1X@201174,4EHE5@85012,COG1609@1,COG1609@2	NA|NA|NA	K	Periplasmic binding protein-like domain
MAG.T22.39_00050	1504319.GM45_3540	1.5e-111	409.5	unclassified Actinobacteria (class)			4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120		R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000				Bacteria	2HNPZ@201174,3UXM7@52018,COG1082@1,COG1082@2	NA|NA|NA	G	Xylose isomerase-like TIM barrel
MAG.T22.39_00051	1504319.GM45_3535	1.2e-94	353.2	Actinobacteria	iolC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044262,GO:0044424,GO:0044464,GO:0046434,GO:0046835,GO:0071704,GO:1901575	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120		R05661	RC00002,RC00017	ko00000,ko00001,ko01000			iYO844.BSU39740	Bacteria	2GM3N@201174,COG0524@1,COG0524@2	NA|NA|NA	G	PFAM PfkB domain protein
MAG.T22.39_00052	1504319.GM45_3530	5.7e-97	360.9	Actinobacteria													Bacteria	2GKTN@201174,COG1830@1,COG1830@2	NA|NA|NA	G	deoxyribose-phosphate aldolase
MAG.T22.39_00053	1504319.GM45_3525	1.6e-104	386.0	Actinobacteria	iolB		5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120		R08503	RC00541	ko00000,ko00001,ko01000				Bacteria	2GM8S@201174,COG3718@1,COG3718@2	NA|NA|NA	G	PFAM Myo-inositol catabolism IolB domain protein
MAG.T22.39_00054	231434.JQJH01000012_gene2895	1.3e-193	682.9	Beijerinckiaceae	iolD	GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0071704,GO:1901575	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120		R08603	RC02331	ko00000,ko00001,ko01000			iYO844.BSU39730	Bacteria	1MW0P@1224,2TR12@28211,3NC50@45404,COG3962@1,COG3962@2	NA|NA|NA	E	Thiamine pyrophosphate enzyme, central domain
MAG.T22.39_00055	1504319.GM45_3550	4.9e-129	467.6	Actinobacteria	iolTA			ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GKIJ@201174,COG1879@1,COG1879@2	NA|NA|NA	G	ABC transporter substrate-binding protein
MAG.T22.39_00056	1504319.GM45_3555	5.7e-133	480.7	unclassified Actinobacteria (class)	iolTB			ko:K02057,ko:K03466		M00221			ko00000,ko00002,ko02000,ko03036	3.A.1.2,3.A.12			Bacteria	2I5GY@201174,3UXSS@52018,COG1172@1,COG1172@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
MAG.T22.39_00057	1122609.AUGT01000005_gene1602	8.2e-108	396.7	Propionibacteriales	iolTC		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	2GJDV@201174,4DNR4@85009,COG1129@1,COG1129@2	NA|NA|NA	G	ATPases associated with a variety of cellular activities
MAG.T22.39_00058	1504319.GM45_3565	5.2e-123	447.6	unclassified Actinobacteria (class)	iolG		1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130		R01183,R09951	RC00182	ko00000,ko00001,ko01000				Bacteria	2GK0F@201174,3UWQM@52018,COG0673@1,COG0673@2	NA|NA|NA	S	dehydrogenases and related proteins
MAG.T22.39_00059	529884.Rhola_00013390	9.2e-71	273.9	Bacteria			1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1091@1,COG1091@2	NA|NA|NA	M	dTDP-4-dehydrorhamnose reductase activity
MAG.T22.39_00060	1122622.ATWJ01000012_gene856	2.4e-165	588.6	Intrasporangiaceae				ko:K07133					ko00000				Bacteria	2GK4E@201174,4FGT8@85021,COG1373@1,COG1373@2	NA|NA|NA	S	Domain of unknown function (DUF4143)
MAG.T22.39_00061	1463895.JODA01000036_gene1868	1.9e-07	62.4	Actinobacteria													Bacteria	2EDIK@1,2GQPY@201174,337EH@2	NA|NA|NA		
MAG.T22.39_00062	1386089.N865_15170	4.4e-77	295.0	Intrasporangiaceae				ko:K02529,ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035,ko03000				Bacteria	2GN16@201174,4FFSB@85021,COG1879@1,COG1879@2	NA|NA|NA	K	Periplasmic binding protein domain
MAG.T22.39_00063	44060.JODL01000002_gene2071	3.1e-119	435.3	Actinobacteria	phyH												Bacteria	2GNTX@201174,COG5285@1,COG5285@2	NA|NA|NA	Q	Phytanoyl-CoA dioxygenase
MAG.T22.39_00064	1504319.GM45_0625	7.2e-74	283.9	Actinobacteria	pepE	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.11.2,3.4.13.21	ko:K01256,ko:K05995	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GZK5@201174,COG3340@1,COG3340@2	NA|NA|NA	E	Belongs to the peptidase S51 family
MAG.T22.39_00065	1184607.AUCHE_05_03520	2.1e-40	172.2	Actinobacteria	mauF		2.7.11.1	ko:K03466,ko:K06196,ko:K12132					ko00000,ko01000,ko01001,ko02000,ko03036	3.A.12,5.A.1.2			Bacteria	2IMP9@201174,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein
MAG.T22.39_00066	1035308.AQYY01000002_gene111	5.1e-41	175.3	Peptococcaceae													Bacteria	1V0ES@1239,24Q6Z@186801,26717@186807,COG1275@1,COG1275@2	NA|NA|NA	P	Voltage-dependent anion channel
MAG.T22.39_00067	1123320.KB889686_gene602	3.3e-144	518.5	Actinobacteria	ddc												Bacteria	2GK3J@201174,COG0076@1,COG0076@2	NA|NA|NA	E	decarboxylase
MAG.T22.39_00068	397278.JOJN01000004_gene1392	5.5e-45	187.6	Propionibacteriales	bioY			ko:K02014,ko:K03523	ko02010,map02010	M00581,M00582			ko00000,ko00001,ko00002,ko02000	1.B.14,2.A.88.1,2.A.88.2			Bacteria	2GJ53@201174,4DSED@85009,COG1268@1,COG1268@2	NA|NA|NA	S	BioY family
MAG.T22.39_00069	767029.HMPREF9154_1484	1.4e-42	179.5	Propionibacteriales													Bacteria	299E4@1,2GM90@201174,2ZWGX@2,4DQ7U@85009	NA|NA|NA	S	Protein of unknown function (DUF3145)
MAG.T22.39_00070	351607.Acel_0874	4.1e-12	76.6	Frankiales			2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2I16G@201174,4ERDY@85013,COG4799@1,COG4799@2	NA|NA|NA	I	PFAM carboxyl transferase
MAG.T22.39_00072	76636.JOEC01000002_gene1857	3.7e-30	137.9	Actinobacteria			5.1.3.29	ko:K02431			R10764	RC00563	ko00000,ko01000				Bacteria	2INSY@201174,COG4154@1,COG4154@2	NA|NA|NA	G	Belongs to the RbsD FucU family
MAG.T22.39_00074	865938.Weevi_1329	8.7e-14	84.0	Flavobacteriia				ko:K21471					ko00000,ko01000,ko01002,ko01011				Bacteria	1HX46@117743,4NGHH@976,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase, M23
MAG.T22.39_00075	1121272.KB903252_gene1027	4.9e-69	268.1	Micromonosporales			6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000				Bacteria	2HI2Z@201174,4DBDA@85008,COG0189@1,COG0189@2	NA|NA|NA	HJ	ligase activity
MAG.T22.39_00076	1961.JOAK01000006_gene4758	2.5e-17	96.3	Actinobacteria													Bacteria	2IAVM@201174,COG0596@1,COG0596@2	NA|NA|NA	S	Alpha beta hydrolase
MAG.T22.39_00077	754252.PFREUD_21660	7.1e-37	160.2	Actinobacteria	lacB	GO:0003674,GO:0003824,GO:0004751,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.1.1.222,2.1.1.64,5.3.1.26,5.3.1.6	ko:K00568,ko:K01808,ko:K01819	ko00030,ko00051,ko00052,ko00130,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00130,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00117,M00165,M00167	R01056,R03240,R04988,R05614,R08769,R08781,R09030	RC00003,RC00376,RC00392,RC00434,RC01895	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKJG@201174,COG0698@1,COG0698@2	NA|NA|NA	G	Ribose 5-phosphate isomerase
MAG.T22.39_00078	930166.CD58_10670	1.6e-60	240.0	Gammaproteobacteria	rbsK		2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1MV5B@1224,1RNVY@1236,COG0524@1,COG0524@2	NA|NA|NA	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAG.T22.39_00079	446469.Sked_12300	2.4e-77	295.8	Actinobacteria													Bacteria	2GJD2@201174,COG3662@1,COG3662@2	NA|NA|NA	Q	protein conserved in bacteria
MAG.T22.39_00080	1504319.GM45_3220	6.9e-87	327.8	unclassified Actinobacteria (class)	sprI		3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	2GJ96@201174,3UWP8@52018,COG0265@1,COG0265@2	NA|NA|NA	O	Trypsin
MAG.T22.39_00081	269800.Tfu_1961	7.5e-71	274.2	Streptosporangiales	sua5	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	2GK2X@201174,4EIA3@85012,COG0009@1,COG0009@2	NA|NA|NA	J	Belongs to the SUA5 family
MAG.T22.39_00085	64471.sync_1115	4.5e-19	101.3	Synechococcus													Bacteria	1GH79@1117,1H3IP@1129,2BSCR@1,32MEP@2	NA|NA|NA	S	Cupin domain
MAG.T22.39_00086	1122599.AUGR01000005_gene1973	5e-119	434.9	Oceanospirillales													Bacteria	1MWUX@1224,1RQ8G@1236,1XK8Z@135619,COG0076@1,COG0076@2	NA|NA|NA	E	Glutamate decarboxylase and related PLP-dependent
MAG.T22.39_00088	477641.MODMU_1334	2.5e-14	85.5	Frankiales	pppA		3.4.23.43	ko:K02654		M00331			ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2			Bacteria	2GJ7K@201174,4ESYI@85013,COG1989@1,COG1989@2	NA|NA|NA	NOU	peptidase A24A prepilin type IV
MAG.T22.39_00089	1120936.KB907223_gene2498	2.8e-50	205.7	Streptosporangiales	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2552c	Bacteria	2GPQQ@201174,4EGBW@85012,COG0169@1,COG0169@2	NA|NA|NA	E	Shikimate dehydrogenase substrate binding domain
MAG.T22.39_00090	1048339.KB913029_gene3959	3.4e-72	278.9	Frankiales	mltG			ko:K07082					ko00000				Bacteria	2GKGQ@201174,4ESC2@85013,COG1559@1,COG1559@2	NA|NA|NA	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MAG.T22.39_00091	1121372.AULK01000001_gene2079	2e-29	135.6	Microbacteriaceae	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07447					ko00000,ko01000				Bacteria	2IQB0@201174,4FP2B@85023,COG0816@1,COG0816@2	NA|NA|NA	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MAG.T22.39_00092	656024.FsymDg_3561	3.7e-311	1073.9	Frankiales	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GIUG@201174,4ERRJ@85013,COG0013@1,COG0013@2	NA|NA|NA	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MAG.T22.39_00094	653045.Strvi_1677	5.2e-49	201.4	Actinobacteria	atpH			ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2GMJ5@201174,COG0712@1,COG0712@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T22.39_00095	469371.Tbis_0898	3.1e-242	844.3	Pseudonocardiales	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	Bacteria	2GJRJ@201174,4E0X3@85010,COG0056@1,COG0056@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MAG.T22.39_00096	1463920.JOGB01000028_gene5190	4.2e-92	344.7	Actinobacteria	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	Bacteria	2GJ7Q@201174,COG0224@1,COG0224@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MAG.T22.39_00097	1504319.GM45_6105	7.2e-227	793.1	unclassified Actinobacteria (class)	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1			Bacteria	2GIY6@201174,3UW86@52018,COG0055@1,COG0055@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MAG.T22.39_00098	591157.SSLG_04718	2.4e-23	115.2	Actinobacteria	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2IHNZ@201174,COG0355@1,COG0355@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane
MAG.T22.39_00099	479433.Caci_1221	2.8e-68	265.0	Actinobacteria	yvqK		2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMHN@201174,COG2096@1,COG2096@2	NA|NA|NA	S	adenosyltransferase
MAG.T22.39_00100	351607.Acel_0657	8.3e-150	537.0	Frankiales	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100		R00660	RC00350	ko00000,ko00001,ko01000,ko01011				Bacteria	2GJPW@201174,4ERJ6@85013,COG0766@1,COG0766@2	NA|NA|NA	M	Belongs to the EPSP synthase family. MurA subfamily
MAG.T22.39_00101	266940.Krad_1273	4.4e-20	104.0	Actinobacteria													Bacteria	2E3JG@1,2GU6T@201174,32YHV@2	NA|NA|NA		
MAG.T22.39_00102	479433.Caci_1226	4.7e-261	907.1	Actinobacteria	meaA		5.4.99.2,5.4.99.63	ko:K01849,ko:K14447	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM65@201174,COG1884@1,COG1884@2,COG2185@1,COG2185@2	NA|NA|NA	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAG.T22.39_00103	101510.RHA1_ro01459	1.3e-90	339.3	Nocardiaceae	nucS			ko:K07503					ko00000,ko01000				Bacteria	2GIYB@201174,4FW2E@85025,COG1637@1,COG1637@2	NA|NA|NA	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MAG.T22.39_00104	208439.AJAP_06335	1.7e-201	709.1	Pseudonocardiales			1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3	ko:K00074,ko:K01782,ko:K05556	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01057,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01057,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087,M00779	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094,R09306,R09307,R09308	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02484,RC02485	ko00000,ko00001,ko00002,ko01000,ko01008				Bacteria	2GJBM@201174,4DX5C@85010,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
MAG.T22.39_00105	1068980.ARVW01000001_gene4777	8.2e-23	112.8	Pseudonocardiales													Bacteria	2E3EP@1,2GQST@201174,32YDP@2,4E6A7@85010	NA|NA|NA	S	ATP- GTP-binding protein
MAG.T22.39_00106	1504319.GM45_6140	1e-75	290.0	unclassified Actinobacteria (class)				ko:K07018					ko00000				Bacteria	2GP8G@201174,3UX9V@52018,COG2945@1,COG2945@2	NA|NA|NA	S	hydrolase of the alpha beta
MAG.T22.39_00107	479434.Sthe_0722	9.1e-30	137.5	Thermomicrobia	oatA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K19172					ko00000,ko02048				Bacteria	27Z3D@189775,2G7EM@200795,COG1835@1,COG1835@2,COG2755@1,COG2755@2	NA|NA|NA	I	Acyltransferase family
MAG.T22.39_00108	105425.BBPL01000002_gene6550	7e-18	97.4	Streptacidiphilus	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K03571					ko00000,ko03036	9.B.157.1			Bacteria	2GN0I@201174,2NHBF@228398,COG2891@1,COG2891@2	NA|NA|NA	M	rod shape-determining protein (MreD)
MAG.T22.39_00109	1123320.KB889629_gene7889	1.2e-55	223.8	Actinobacteria	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030428,GO:0042546,GO:0043621,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944		ko:K03570					ko00000,ko03036	9.B.157.1			Bacteria	2GJN0@201174,COG1792@1,COG1792@2	NA|NA|NA	M	Involved in formation and maintenance of cell shape
MAG.T22.39_00110	298653.Franean1_5269	5e-161	573.9	Frankiales	mreB			ko:K03569					ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1			Bacteria	2GMD1@201174,4ES3S@85013,COG1077@1,COG1077@2	NA|NA|NA	D	TIGRFAM Cell shape determining protein MreB Mrl
MAG.T22.39_00111	1454010.JEOE01000011_gene2396	1.2e-58	234.2	Actinobacteria													Bacteria	2IBWT@201174,COG4425@1,COG4425@2	NA|NA|NA	S	Alpha/beta-hydrolase family
MAG.T22.39_00112	1146883.BLASA_1542	3.6e-51	207.6	Frankiales	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131			iNJ661.Rv2445c	Bacteria	2IFBU@201174,4ESUM@85013,COG0105@1,COG0105@2	NA|NA|NA	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MAG.T22.39_00113	471852.Tcur_1537	7.6e-07	60.1	Streptosporangiales													Bacteria	2EHND@1,2I8BP@201174,33BE5@2,4EK8T@85012	NA|NA|NA	S	Protein of unknown function (DUF4233)
MAG.T22.39_00114	1048339.KB913029_gene4866	4.8e-121	441.4	Frankiales	folC		6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJP2@201174,4ERQF@85013,COG0285@1,COG0285@2	NA|NA|NA	H	Mur ligase, middle domain protein
MAG.T22.39_00115	269800.Tfu_1936	0.0	1209.1	Streptosporangiales	valS		6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GK8H@201174,4EIDQ@85012,COG0525@1,COG0525@2	NA|NA|NA	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MAG.T22.39_00116	1348663.KCH_27660	2.1e-193	681.8	Kitasatospora	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03544	ko04112,map04112				ko00000,ko00001,ko03110				Bacteria	2GJXQ@201174,2M1WE@2063,COG1219@1,COG1219@2	NA|NA|NA	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MAG.T22.39_00117	1504319.GM45_5765	5.3e-91	340.5	unclassified Actinobacteria (class)	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	2GKNK@201174,3UWGF@52018,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MAG.T22.39_00118	1193181.BN10_940010	1e-73	283.1	Intrasporangiaceae	clpP		3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	2GK5C@201174,4FEPP@85021,COG0740@1,COG0740@2	NA|NA|NA	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MAG.T22.39_00119	1108045.GORHZ_141_00770	8.2e-08	62.4	Actinobacteria													Bacteria	2EMYX@1,2GZ6D@201174,33FM2@2	NA|NA|NA		
MAG.T22.39_00122	58123.JOFJ01000005_gene1557	1.7e-66	259.2	Actinobacteria													Bacteria	2GMG2@201174,COG2041@1,COG2041@2	NA|NA|NA	M	Oxidoreductase molybdopterin binding
MAG.T22.39_00123	479433.Caci_7398	1.9e-52	212.6	Actinobacteria				ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200		R00519	RC02796	ko00000,ko00001				Bacteria	2GNYK@201174,COG2864@1,COG2864@2	NA|NA|NA	C	Prokaryotic cytochrome b561
MAG.T22.39_00124	1121933.AUHH01000015_gene458	1.3e-31	142.5	Propionibacteriales				ko:K07341					ko00000,ko02048				Bacteria	2IR34@201174,4DS3A@85009,COG3654@1,COG3654@2	NA|NA|NA	S	TIGRFAM death-on-curing family protein
MAG.T22.39_00125	222534.KB893678_gene1090	5.3e-11	73.2	Actinobacteria													Bacteria	2EM5W@1,2GVYV@201174,335MU@2	NA|NA|NA	S	Ribbon-helix-helix protein, copG family
MAG.T22.39_00126	1380370.JIBA01000010_gene2524	3.7e-128	464.9	Intrasporangiaceae													Bacteria	2GKAF@201174,4FFPW@85021,COG0520@1,COG0520@2	NA|NA|NA	E	Cysteine desulfurase
MAG.T22.39_00127	1313172.YM304_36240	1.5e-51	209.9	Actinobacteria			2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000				Bacteria	2I6J5@201174,COG2227@1,COG2227@2	NA|NA|NA	H	Methyltransferase domain
MAG.T22.39_00128	405948.SACE_0493	2e-38	166.0	Pseudonocardiales													Bacteria	2AVV0@1,2GJKP@201174,31MNQ@2,4E2PK@85010	NA|NA|NA	S	Protein of unknown function (DUF3159)
MAG.T22.39_00129	1463934.JOCF01000040_gene3456	2.5e-88	332.0	Actinobacteria	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKUI@201174,COG0266@1,COG0266@2	NA|NA|NA	L	Belongs to the FPG family
MAG.T22.39_00130	1894.JOER01000008_gene704	8.5e-113	413.7	Actinobacteria	ltaE		4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230		R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000				Bacteria	2GJ0V@201174,COG2008@1,COG2008@2	NA|NA|NA	E	Threonine aldolase
MAG.T22.39_00131	44060.JODL01000005_gene751	1.3e-22	111.7	Actinobacteria	yjbH	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944											Bacteria	2GJNX@201174,COG2761@1,COG2761@2	NA|NA|NA	Q	DSBA oxidoreductase
MAG.T22.39_00133	1463820.JOGW01000002_gene6444	4.5e-91	341.7	Actinobacteria	ecfT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656		ko:K02008,ko:K16783,ko:K16785	ko02010,map02010	M00245,M00246,M00581,M00582			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2GKHK@201174,COG0619@1,COG0619@2	NA|NA|NA	P	cobalt transport
MAG.T22.39_00134	1449355.JQNR01000003_gene515	3.7e-24	118.6	Actinobacteria													Bacteria	2E883@1,2I8J4@201174,332M6@2	NA|NA|NA		
MAG.T22.39_00135	351607.Acel_0946	2.2e-44	186.4	Actinobacteria			4.2.1.129,4.2.1.137,5.4.99.17	ko:K06045,ko:K16927,ko:K18115	ko00909,ko01110,map00909,map01110	M00582	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.32			Bacteria	2GIRK@201174,COG1657@1,COG1657@2	NA|NA|NA	I	Prenyltransferase and squalene oxidase repeat
MAG.T22.39_00137	1463857.JOFZ01000012_gene1730	5.3e-19	99.8	Actinobacteria													Bacteria	2EFWK@1,2IQXQ@201174,339NW@2	NA|NA|NA		
MAG.T22.39_00138	1394178.AWOO02000084_gene1160	2e-135	488.8	Streptosporangiales		GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008076,GO:0008150,GO:0008152,GO:0009117,GO:0009898,GO:0009987,GO:0010959,GO:0012505,GO:0012506,GO:0015459,GO:0016020,GO:0016021,GO:0016192,GO:0016247,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019637,GO:0019897,GO:0019898,GO:0030141,GO:0030424,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031234,GO:0031410,GO:0031982,GO:0032879,GO:0032880,GO:0032940,GO:0032991,GO:0033267,GO:0034641,GO:0034702,GO:0034703,GO:0034705,GO:0034762,GO:0034765,GO:0035579,GO:0036230,GO:0042119,GO:0042581,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043266,GO:0043269,GO:0043299,GO:0043312,GO:0044224,GO:0044237,GO:0044238,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046496,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051186,GO:0051234,GO:0055086,GO:0055114,GO:0060341,GO:0065007,GO:0065009,GO:0070820,GO:0070821,GO:0070995,GO:0071704,GO:0071944,GO:0072524,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098772,GO:0098796,GO:0098797,GO:0098805,GO:0099106,GO:0099503,GO:0120025,GO:0120038,GO:1901360,GO:1901379,GO:1901564,GO:1902495,GO:1903827,GO:1904062,GO:1990031,GO:1990351,GO:2000008											Bacteria	2GMT5@201174,4EG7B@85012,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo/keto reductase family
MAG.T22.39_00139	1463936.JOJI01000017_gene7547	4.4e-32	144.8	Actinobacteria		GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136											Bacteria	2AN86@1,2HWWU@201174,31D67@2	NA|NA|NA	S	membrane
MAG.T22.39_00140	1120950.KB892707_gene4776	1.8e-69	269.2	Propionibacteriales	pspA			ko:K03969					ko00000				Bacteria	2GP0K@201174,4DPJS@85009,COG1842@1,COG1842@2	NA|NA|NA	KT	PspA/IM30 family
MAG.T22.39_00141	2002.JOEQ01000006_gene1471	1.8e-87	329.3	Streptosporangiales	htpX			ko:K03799		M00743			ko00000,ko00002,ko01000,ko01002				Bacteria	2GMJF@201174,4EGS5@85012,COG0501@1,COG0501@2	NA|NA|NA	O	Peptidase family M48
MAG.T22.39_00142	749414.SBI_05308	7.6e-63	246.9	Actinobacteria													Bacteria	2GP15@201174,31PZA@2,arCOG04740@1	NA|NA|NA		
MAG.T22.39_00143	105425.BBPL01000031_gene4466	1.8e-170	605.5	Streptacidiphilus	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM59@201174,2NFE0@228398,COG0379@1,COG0379@2	NA|NA|NA	H	Quinolinate synthetase A protein
MAG.T22.39_00144	1003195.SCAT_1287	7.9e-50	203.0	Actinobacteria	erpA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564		ko:K13628,ko:K15724					ko00000,ko03016				Bacteria	2IHR0@201174,COG0316@1,COG0316@2	NA|NA|NA	S	Belongs to the HesB IscA family
MAG.T22.39_00145	446462.Amir_2610	2.1e-96	359.0	Pseudonocardiales			1.13.11.8	ko:K04100,ko:K15777	ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120		R01632,R03550,R04280,R08836,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000				Bacteria	2GKTV@201174,4DYEZ@85010,COG3384@1,COG3384@2	NA|NA|NA	S	PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase
MAG.T22.39_00146	1123320.KB889675_gene3934	5.8e-127	460.7	Actinobacteria	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100		R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000			iAF987.Gmet_2683	Bacteria	2GKBG@201174,COG0524@1,COG0524@2	NA|NA|NA	G	Ribokinase
MAG.T22.39_00147	1298863.AUEP01000009_gene90	1.9e-59	235.7	Propionibacteriales	aat		2.3.2.6	ko:K00684			R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000				Bacteria	2IFT7@201174,4DQD7@85009,COG2360@1,COG2360@2	NA|NA|NA	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MAG.T22.39_00148	1120936.KB907210_gene5871	7.7e-54	218.0	Streptosporangiales			2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GJ2B@201174,4EHSY@85012,COG1104@1,COG1104@2	NA|NA|NA	E	Beta-eliminating lyase
MAG.T22.39_00149	1504319.GM45_0705	6.4e-74	284.3	unclassified Actinobacteria (class)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6			Bacteria	2GNXA@201174,3UWMS@52018,COG1622@1,COG1622@2	NA|NA|NA	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MAG.T22.39_00150	590998.Celf_2189	1.2e-252	879.0	Cellulomonadaceae	ctaD	GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6			Bacteria	2GJHX@201174,4F1WI@85016,COG0843@1,COG0843@2	NA|NA|NA	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MAG.T22.39_00151	351607.Acel_0958	9.3e-28	129.8	Frankiales	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2D9MJ@1,2IFFM@201174,32TTI@2,4ETA5@85013	NA|NA|NA	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family
MAG.T22.39_00152	1123320.KB889675_gene3928	3.7e-75	288.9	Actinobacteria	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576											Bacteria	2GJBA@201174,COG1376@1,COG1376@2	NA|NA|NA	L	ErfK YbiS YcfS YnhG family protein
MAG.T22.39_00153	1312959.KI914672_gene3438	3.4e-108	399.4	Actinobacteria	pstI			ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GJYH@201174,COG1404@1,COG1404@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T22.39_00154	1504319.GM45_0755	2.3e-203	715.3	unclassified Actinobacteria (class)	petD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944		ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162			ko00000,ko00001,ko00002,ko00194,ko03029				Bacteria	2GJ1E@201174,3UWCW@52018,COG1290@1,COG1290@2	NA|NA|NA	C	Cytochrome b/b6/petB
MAG.T22.39_00155	1504319.GM45_0760	4e-97	361.7	unclassified Actinobacteria (class)	qcrA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03890,ko:K15878	ko00190,ko01100,map00190,map01100	M00151			ko00000,ko00001,ko00002			iAF987.Gmet_0538	Bacteria	2GIX6@201174,3UWCF@52018,COG0723@1,COG0723@2	NA|NA|NA	C	Rieske [2Fe-2S] domain
MAG.T22.39_00156	1504319.GM45_0765	4e-78	298.1	unclassified Actinobacteria (class)	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K00406,ko:K03889	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00151,M00156			ko00000,ko00001,ko00002	3.D.4.3			Bacteria	2GKUB@201174,3UWHN@52018,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome C oxidase, cbb3-type, subunit III
MAG.T22.39_00157	55952.BU52_09690	2.3e-78	298.5	Actinobacteria	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6		iJN678.ctaE	Bacteria	2GKK8@201174,COG1845@1,COG1845@2	NA|NA|NA	C	cytochrome c oxidase, subunit III
MAG.T22.39_00158	67373.JOBF01000015_gene5136	1.6e-39	169.5	Actinobacteria		GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944											Bacteria	2II71@201174,COG0784@1,COG0784@2	NA|NA|NA	T	response regulator
MAG.T22.39_00159	1205680.CAKO01000007_gene4252	4.5e-35	153.7	Alphaproteobacteria													Bacteria	1R4T9@1224,2TRFM@28211,COG3618@1,COG3618@2	NA|NA|NA	S	PFAM amidohydrolase 2
MAG.T22.39_00160	1123024.AUII01000050_gene622	2.2e-84	318.9	Pseudonocardiales													Bacteria	2IAK8@201174,4E560@85010,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_00161	1123024.AUII01000050_gene623	2e-152	545.8	Pseudonocardiales	MA20_01175												Bacteria	2GMDH@201174,4E4TA@85010,COG2072@1,COG2072@2	NA|NA|NA	P	Flavin-binding monooxygenase-like
MAG.T22.39_00162	1121374.KB891589_gene46	2.3e-90	339.3	Gammaproteobacteria													Bacteria	1MUPD@1224,1RN3S@1236,COG0520@1,COG0520@2	NA|NA|NA	E	aminotransferase
MAG.T22.39_00163	446470.Snas_2549	2.3e-57	229.6	Glycomycetales	glxK		2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000				Bacteria	2GKHX@201174,4EZNE@85014,COG1929@1,COG1929@2	NA|NA|NA	G	Glycerate kinase family
MAG.T22.39_00164	1123322.KB904651_gene372	4e-277	960.7	Actinobacteria	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GISS@201174,COG0210@1,COG0210@2	NA|NA|NA	L	DNA helicase
MAG.T22.39_00165	1043205.AFYF01000063_gene2729	5.5e-124	451.1	Intrasporangiaceae			2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ5S@201174,4FFJZ@85021,COG0626@1,COG0626@2	NA|NA|NA	E	cystathionine gamma-synthase
MAG.T22.39_00166	755178.Cyan10605_0700	3.2e-09	68.6	Cyanobacteria													Bacteria	1G09B@1117,COG0642@1,COG0745@1,COG0745@2,COG2203@1,COG2203@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T22.39_00167	529884.Rhola_00002480	8.7e-33	148.7	Microbacteriaceae													Bacteria	2GWSQ@201174,4FQRQ@85023,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_00168	1297742.A176_00262	3.5e-35	158.7	Myxococcales				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	1MX1F@1224,2WQUW@28221,2YUE1@29,42UTB@68525,COG1470@1,COG1470@2,COG2885@1,COG2885@2,COG4719@1,COG4719@2	NA|NA|NA	M	Belongs to the ompA family
MAG.T22.39_00169	529884.Rhola_00002470	3.9e-53	214.9	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HSNY@201174,4FPMD@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_00171	110319.CF8_0773	1.6e-133	482.6	Propionibacteriales	guaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GKVS@201174,4DN1G@85009,COG0516@1,COG0516@2	NA|NA|NA	F	IMP dehydrogenase / GMP reductase domain
MAG.T22.39_00172	35754.JNYJ01000004_gene5910	1e-212	746.1	Micromonosporales	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GITZ@201174,4D9JG@85008,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MAG.T22.39_00173	1504319.GM45_2435	9.6e-66	257.3	unclassified Actinobacteria (class)	litR			ko:K22491					ko00000,ko03000				Bacteria	2I8T8@201174,3UXIG@52018,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T22.39_00174	1157635.KB892002_gene4166	2.7e-35	154.5	Actinobacteria	wblB			ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQS5@201174,32S23@2	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T22.39_00175	710696.Intca_1017	3.1e-131	475.3	Intrasporangiaceae	groL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	2GKC9@201174,4FF25@85021,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MAG.T22.39_00177	1048339.KB913029_gene4683	2.3e-195	688.7	Frankiales	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK2C@201174,4ESAT@85013,COG0171@1,COG0171@2,COG0388@1,COG0388@2	NA|NA|NA	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAG.T22.39_00178	479431.Namu_3997	1.1e-144	520.4	Frankiales													Bacteria	2GIUM@201174,4ES6I@85013,COG0477@1,COG0477@2,COG2211@1,COG2211@2	NA|NA|NA	P	Major facilitator superfamily
MAG.T22.39_00179	479432.Sros_2590	1.3e-92	346.3	Streptosporangiales	panB		2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJP6@201174,4EGTN@85012,COG0413@1,COG0413@2	NA|NA|NA	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MAG.T22.39_00180	105420.BBPO01000035_gene431	4e-82	311.2	Streptacidiphilus	npdG		1.5.1.40	ko:K06988					ko00000,ko01000				Bacteria	2GMZ5@201174,2NEN9@228398,COG2085@1,COG2085@2	NA|NA|NA	S	Acetohydroxy acid isomeroreductase, NADPH-binding domain
MAG.T22.39_00182	469371.Tbis_1246	1.1e-11	75.1	Bacteria													Bacteria	2EHMB@1,33BD3@2	NA|NA|NA		
MAG.T22.39_00183	711393.AYRX01000022_gene1044	2.7e-118	431.8	Actinobacteria	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	2GKIZ@201174,COG0024@1,COG0024@2	NA|NA|NA	E	Methionine aminopeptidase
MAG.T22.39_00184	404589.Anae109_4035	8.2e-68	263.8	Proteobacteria	ppgK		2.7.1.2,2.7.1.63,5.3.1.9	ko:K00845,ko:K00886,ko:K01810	ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114,M00549	R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321	RC00002,RC00017,RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1NSQA@1224,COG1940@1,COG1940@2	NA|NA|NA	GK	PFAM ROK family protein
MAG.T22.39_00185	1463854.JOHT01000012_gene4400	3.2e-35	154.8	Actinobacteria													Bacteria	2GP6A@201174,COG1846@1,COG1846@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_00186	196162.Noca_2016	1.4e-51	209.9	Propionibacteriales	yaaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700		ko:K09861					ko00000				Bacteria	2GJPM@201174,4DPK6@85009,COG3022@1,COG3022@2	NA|NA|NA	S	Belongs to the UPF0246 family
MAG.T22.39_00187	398512.JQKC01000001_gene2453	1e-07	63.9	Ruminococcaceae													Bacteria	1VE6X@1239,24MMJ@186801,2ECRX@1,32VVN@2,3WQ77@541000	NA|NA|NA		
MAG.T22.39_00188	1463936.JOJI01000016_gene280	7.2e-103	380.9	Actinobacteria	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12	ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko03032				Bacteria	2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2	NA|NA|NA	GL	phosphoglycerate mutase
MAG.T22.39_00189	1193181.BN10_730017	1.2e-52	213.4	Intrasporangiaceae				ko:K07164					ko00000				Bacteria	2GP84@201174,4FFIN@85021,COG1579@1,COG1579@2	NA|NA|NA	S	C4-type zinc ribbon domain
MAG.T22.39_00190	1123320.KB889569_gene5430	1.9e-70	272.7	Actinobacteria	yqfO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKHZ@201174,COG0327@1,COG0327@2	NA|NA|NA	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MAG.T22.39_00192	1254432.SCE1572_30035	2e-52	212.2	Myxococcales													Bacteria	1R8RC@1224,2WZ68@28221,2Z1EX@29,430PA@68525,COG3576@1,COG3576@2	NA|NA|NA	S	Pfam:Pyridox_oxidase
MAG.T22.39_00193	1068978.AMETH_5837	4.7e-82	311.6	Pseudonocardiales	tbpA			ko:K02064	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19			Bacteria	2GMWD@201174,4E0PA@85010,COG4143@1,COG4143@2	NA|NA|NA	H	ABC transporter, periplasmic binding protein, thiB subfamily
MAG.T22.39_00194	1306406.ASHX01000001_gene303	8.6e-69	268.1	Actinobacteria	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682		ko:K02063	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	Bacteria	2GKDH@201174,COG1178@1,COG1178@2	NA|NA|NA	P	ABC-type Fe3 transport system permease component
MAG.T22.39_00195	384765.SIAM614_24927	2.4e-46	192.2	Alphaproteobacteria	fbpC		3.6.3.30	ko:K02010	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10			Bacteria	1MU3I@1224,2TQMJ@28211,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
MAG.T22.39_00196	512565.AMIS_44500	1.8e-06	60.5	Bacteria													Bacteria	COG4129@1,COG4129@2	NA|NA|NA		
MAG.T22.39_00197	1210045.ALNP01000006_gene5035	7.2e-51	206.8	Actinobacteria	ahpE		1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	2GKME@201174,COG1225@1,COG1225@2	NA|NA|NA	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAG.T22.39_00198	471852.Tcur_1647	4.7e-46	190.7	Streptosporangiales													Bacteria	2B57P@1,2IFRB@201174,31Y1M@2,4EJAB@85012	NA|NA|NA	S	Protein of unknown function (DUF3052)
MAG.T22.39_00199	644283.Micau_4703	0.0	1371.7	Micromonosporales	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJRE@201174,4DABZ@85008,COG2609@1,COG2609@2	NA|NA|NA	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MAG.T22.39_00200	1449353.JQMQ01000004_gene6292	3.5e-83	315.5	Streptacidiphilus													Bacteria	2GIZ3@201174,2NKDE@228398,COG1814@1,COG1814@2	NA|NA|NA	S	VIT family
MAG.T22.39_00201	1385520.N802_00405	3.4e-145	521.5	Intrasporangiaceae	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.12,2.3.1.180,2.3.1.39	ko:K00627,ko:K00645,ko:K00648,ko:K02160	ko00010,ko00020,ko00061,ko00333,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00333,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00083,M00307,M00376	R00209,R00742,R01626,R02569,R10707,R11671	RC00004,RC00039,RC00040,RC00367,RC02727,RC02729,RC02742,RC02857,RC02888	br01601,ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GME0@201174,4FFAJ@85021,COG0331@1,COG0331@2,COG0511@1,COG0511@2	NA|NA|NA	I	Biotin attachment protein
MAG.T22.39_00202	1123320.KB889676_gene2823	8e-108	397.1	Actinobacteria	fabH		2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GJP8@201174,COG0332@1,COG0332@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAG.T22.39_00203	1463934.JOCF01000012_gene5422	8.3e-24	115.9	Actinobacteria	acpP			ko:K02078					ko00000,ko00001				Bacteria	2IQ43@201174,COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAG.T22.39_00204	351607.Acel_0875	8.5e-144	516.9	Frankiales	fabF		2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GIY4@201174,4ES79@85013,COG0304@1,COG0304@2	NA|NA|NA	I	Belongs to the beta-ketoacyl-ACP synthases family
MAG.T22.39_00207	1246995.AFR_35445	3.5e-12	77.4	Micromonosporales													Bacteria	29QVV@1,2GVRY@201174,30BW4@2,4DFV2@85008	NA|NA|NA		
MAG.T22.39_00208	1121924.ATWH01000005_gene2614	1.5e-23	115.5	Microbacteriaceae													Bacteria	2GXCS@201174,4FSF8@85023,COG2361@1,COG2361@2	NA|NA|NA	S	Protein of unknown function DUF86
MAG.T22.39_00209	858619.CVAR_0768	2.3e-25	122.1	Corynebacteriaceae				ko:K07075					ko00000				Bacteria	22QW8@1653,2HQBV@201174,COG1669@1,COG1669@2	NA|NA|NA	S	Nucleotidyltransferase domain
MAG.T22.39_00210	1150599.MPHLEI_25666	3.5e-124	451.4	Mycobacteriaceae	yhhW_2			ko:K06911					ko00000				Bacteria	234Q9@1762,2GIY9@201174,COG1741@1,COG1741@2	NA|NA|NA	S	Belongs to the pirin family
MAG.T22.39_00211	298654.FraEuI1c_3650	3.5e-08	64.7	Bacteria													Bacteria	COG0229@1,COG0229@2	NA|NA|NA	O	peptide-methionine (R)-S-oxide reductase activity
MAG.T22.39_00212	882083.SacmaDRAFT_3101	9.5e-99	366.3	Pseudonocardiales	lsfA		1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	2GM74@201174,4E0A5@85010,COG0450@1,COG0450@2	NA|NA|NA	O	Redoxin
MAG.T22.39_00213	1158050.KB895459_gene2483	6.9e-70	270.8	Micrococcaceae													Bacteria	1W9S7@1268,2I2RM@201174,COG0300@1,COG0300@2	NA|NA|NA	S	KR domain
MAG.T22.39_00214	1192034.CAP_2819	1.4e-25	123.6	Myxococcales													Bacteria	1NAQM@1224,2WNXU@28221,2YVQF@29,42RR6@68525,COG1946@1,COG1946@2	NA|NA|NA	I	Thioesterase-like superfamily
MAG.T22.39_00215	1504319.GM45_5045	2.1e-148	532.3	unclassified Actinobacteria (class)	deaD		3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GIUR@201174,3UW8N@52018,COG0513@1,COG0513@2	NA|NA|NA	L	helicase superfamily c-terminal domain
MAG.T22.39_00217	710696.Intca_1335	1.2e-66	259.6	Intrasporangiaceae	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360		ko:K13288	ko03008,map03008				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GJR7@201174,4FE4Z@85021,COG1949@1,COG1949@2	NA|NA|NA	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MAG.T22.39_00218	44060.JODL01000022_gene5067	1.2e-43	183.7	Actinobacteria				ko:K03294					ko00000	2.A.3.2			Bacteria	2GMFE@201174,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
MAG.T22.39_00219	931627.MycrhDRAFT_0145	7.7e-60	237.7	Mycobacteriaceae	lipI												Bacteria	234HX@1762,2GJYR@201174,COG0657@1,COG0657@2	NA|NA|NA	I	Alpha beta hydrolase
MAG.T22.39_00221	479434.Sthe_0078	1.3e-96	360.5	Thermomicrobia													Bacteria	27Y75@189775,2G89T@200795,COG0477@1,COG0477@2	NA|NA|NA	P	Major facilitator superfamily
MAG.T22.39_00222	367299.JOEE01000005_gene3633	5.7e-88	330.9	Intrasporangiaceae	spoU2		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	2GJ12@201174,4FF53@85021,COG0566@1,COG0566@2	NA|NA|NA	J	RRNA methyltransferase
MAG.T22.39_00224	1172179.AUKV01000016_gene2208	7.6e-145	520.8	Actinobacteria													Bacteria	2I7MG@201174,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T22.39_00225	994479.GL877878_gene380	2e-59	235.7	Pseudonocardiales	frcK			ko:K02173					ko00000				Bacteria	2I9H4@201174,4DXR2@85010,COG0572@1,COG0572@2	NA|NA|NA	F	Fructose transport system kinase
MAG.T22.39_00227	593907.Celgi_0245	2.6e-24	119.0	Cellulomonadaceae	resA			ko:K02199					ko00000,ko03110				Bacteria	2GP7J@201174,4F2FS@85016,COG0526@1,COG0526@2	NA|NA|NA	CO	PFAM Redoxin domain protein
MAG.T22.39_00228	1003195.SCAT_0329	1.5e-22	113.6	Actinobacteria				ko:K02351,ko:K07245					ko00000,ko02000	9.B.62.1			Bacteria	2GKIR@201174,COG3336@1,COG3336@2	NA|NA|NA	P	Cytochrome c oxidase
MAG.T22.39_00229	525909.Afer_1709	8.1e-14	84.3	Acidimicrobiia													Bacteria	2HGM2@201174,2ZWPP@2,4CNJ3@84992,arCOG07408@1	NA|NA|NA		
MAG.T22.39_00230	1380390.JIAT01000014_gene6064	2.3e-26	126.3	Rubrobacteria	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6			Bacteria	2HQAR@201174,4CRUU@84995,COG1622@1,COG1622@2,COG2010@1,COG2010@2	NA|NA|NA	C	Cytochrome C oxidase subunit II, transmembrane domain
MAG.T22.39_00232	1367847.JCM7686_1840	1.6e-14	85.5	Proteobacteria													Bacteria	1R2VK@1224,3220G@2,arCOG10157@1	NA|NA|NA	S	EthD domain
MAG.T22.39_00233	460265.Mnod_2527	9.7e-39	166.8	Alphaproteobacteria													Bacteria	1N3VY@1224,28I63@1,2TTW0@28211,2Z897@2	NA|NA|NA	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit
MAG.T22.39_00234	397278.JOJN01000004_gene1437	1.7e-289	1001.9	Propionibacteriales	fbiC		2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK83@201174,4DN7M@85009,COG1060@1,COG1060@2	NA|NA|NA	H	SMART Elongator protein 3 MiaB NifB
MAG.T22.39_00235	1123023.JIAI01000028_gene4506	3.9e-135	488.4	Pseudonocardiales			3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000				Bacteria	2GN50@201174,4DYE1@85010,COG0491@1,COG0491@2,COG0607@1,COG0607@2	NA|NA|NA	P	Zn-dependent hydrolase, glyoxylase
MAG.T22.39_00236	710696.Intca_3540	3.7e-19	100.9	Intrasporangiaceae													Bacteria	2IQIP@201174,4FHX9@85021,COG0607@1,COG0607@2	NA|NA|NA	P	Sulfurtransferase
MAG.T22.39_00238	1386089.N865_03025	8.3e-79	300.4	Intrasporangiaceae	exoA		3.1.11.2	ko:K01142	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKIS@201174,4FEP7@85021,COG0708@1,COG0708@2	NA|NA|NA	L	exodeoxyribonuclease III
MAG.T22.39_00239	1121877.JQKF01000004_gene1066	1.1e-30	140.2	Actinobacteria			3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120		R05287	RC00697	ko00000,ko00001,ko01000				Bacteria	2HHHH@201174,COG1011@1,COG1011@2	NA|NA|NA	S	haloacid dehalogenase
MAG.T22.39_00240	1463917.JODC01000006_gene8139	3.2e-57	229.2	Actinobacteria													Bacteria	290E5@1,2IH3T@201174,2ZN3G@2	NA|NA|NA		
MAG.T22.39_00241	469371.Tbis_1890	1.3e-86	327.4	Pseudonocardiales			3.1.6.14	ko:K01137	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00078,M00079	R07808,R07819		ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ8H@201174,4DZR1@85010,COG3119@1,COG3119@2	NA|NA|NA	P	Sulfatase
MAG.T22.39_00242	1476876.JOJO01000006_gene2475	1e-179	637.1	Actinobacteria	tagF		2.7.8.12	ko:K09809					ko00000,ko01000				Bacteria	2GM0T@201174,COG0463@1,COG0463@2,COG1887@1,COG1887@2	NA|NA|NA	M	CDP-glycerol poly(glycerophosphate) glycerophosphotransferase
MAG.T22.39_00243	1307759.JOMJ01000004_gene2508	5e-13	82.0	Desulfovibrionales													Bacteria	1N9T6@1224,2M8UX@213115,2WT6J@28221,42XKF@68525,COG0615@1,COG0615@2	NA|NA|NA	IM	Sulfotransferase domain
MAG.T22.39_00245	1298867.AUES01000054_gene4879	5.7e-86	325.1	Bradyrhizobiaceae			1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000				Bacteria	1MX9R@1224,2TR4U@28211,3JSWT@41294,COG0654@1,COG0654@2	NA|NA|NA	CH	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T22.39_00246	330084.JNYZ01000011_gene7287	8.8e-47	193.7	Pseudonocardiales	csiR	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K15735					ko00000,ko03000				Bacteria	2HSE5@201174,4E0Y9@85010,COG1802@1,COG1802@2	NA|NA|NA	K	FCD
MAG.T22.39_00247	1278078.G419_16705	2.3e-34	152.1	Nocardiaceae													Bacteria	2I94W@201174,4G4BR@85025,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MAG.T22.39_00248	257310.BB1115	4.3e-54	218.4	Proteobacteria													Bacteria	1MYK7@1224,COG4689@1,COG4689@2	NA|NA|NA	Q	PFAM Acetoacetate decarboxylase
MAG.T22.39_00249	479431.Namu_4858	2.4e-62	245.7	Frankiales													Bacteria	2GKED@201174,4ESKI@85013,COG0179@1,COG0179@2	NA|NA|NA	Q	PFAM fumarylacetoacetate (FAA) hydrolase
MAG.T22.39_00250	561175.KB894105_gene952	1.2e-27	130.2	Streptosporangiales													Bacteria	2HG49@201174,4EKAP@85012,COG0412@1,COG0412@2	NA|NA|NA	Q	Dienelactone hydrolase family
MAG.T22.39_00251	504728.K649_09860	2.9e-38	165.6	Bacteria													Bacteria	COG1802@1,COG1802@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_00252	1869.MB27_37195	1.5e-111	409.5	Micromonosporales													Bacteria	2GN2E@201174,4DHEW@85008,COG0346@1,COG0346@2	NA|NA|NA	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MAG.T22.39_00253	1038922.PflQ2_2336	4e-131	474.6	Pseudomonas fluorescens group			3.5.4.22,4.3.3.7	ko:K01714,ko:K21062	ko00261,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00330,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R02280,R10147	RC00679,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000				Bacteria	1NUUM@1224,1RV2D@1236,1YT4C@136843,COG0329@1,COG0329@2	NA|NA|NA	EM	Dihydrodipicolinate synthetase family
MAG.T22.39_00254	1415630.U771_11500	1.6e-74	286.6	Proteobacteria			1.4.1.1,1.4.1.25,4.3.1.12	ko:K01750,ko:K19244,ko:K19744	ko00250,ko00330,ko00430,ko00472,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map00472,map01100,map01110,map01130,map01230		R00396,R00671,R11031,R11032	RC00006,RC00008,RC00354	ko00000,ko00001,ko01000				Bacteria	1RAMV@1224,COG2423@1,COG2423@2	NA|NA|NA	E	Ornithine cyclodeaminase
MAG.T22.39_00255	585531.HMPREF0063_10242	4.1e-97	361.7	Propionibacteriales	yetM												Bacteria	2GJG5@201174,4DWM5@85009,COG0654@1,COG0654@2	NA|NA|NA	CH	FAD binding domain
MAG.T22.39_00256	1246995.AFR_13065	1.5e-49	203.8	Actinobacteria				ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2IBGG@201174,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T22.39_00257	298654.FraEuI1c_5697	3.2e-132	478.8	Actinobacteria			3.6.3.17	ko:K10441	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJ3F@201174,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MAG.T22.39_00258	298654.FraEuI1c_5696	2e-85	322.8	Frankiales				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GMJW@201174,4EVX6@85013,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_00261	1048339.KB913029_gene2939	5.7e-263	914.1	Frankiales		GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K09118					ko00000				Bacteria	2GMP3@201174,4ERVJ@85013,COG1615@1,COG1615@2	NA|NA|NA	S	Uncharacterised protein family (UPF0182)
MAG.T22.39_00262	1137269.AZWL01000010_gene5069	1.5e-62	246.9	Actinobacteria	lon			ko:K07177	ko02024,map02024				ko00000,ko00001,ko01002				Bacteria	2GJDD@201174,COG3480@1,COG3480@2	NA|NA|NA	T	Belongs to the peptidase S16 family
MAG.T22.39_00264	1449353.JQMQ01000005_gene2332	1.5e-37	162.9	Streptacidiphilus	nudJ			ko:K12152					ko00000,ko01000				Bacteria	2GU6D@201174,2NIE7@228398,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T22.39_00265	452652.KSE_49040	2.2e-102	379.4	Kitasatospora													Bacteria	2GJ9K@201174,2M09M@2063,COG5282@1,COG5282@2	NA|NA|NA	H	Zincin-like metallopeptidase
MAG.T22.39_00266	1504319.GM45_1925	2.4e-19	100.5	Actinobacteria													Bacteria	2E479@1,2GQXY@201174,32Z35@2	NA|NA|NA		
MAG.T22.39_00267	1121385.AQXW01000004_gene972	1.2e-122	446.8	Dermacoccaceae	yodQ		3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000				Bacteria	1ZWDR@145357,2I8IJ@201174,COG0624@1,COG0624@2	NA|NA|NA	E	Peptidase dimerisation domain
MAG.T22.39_00268	1211815.CBYP010000042_gene2412	9.2e-13	81.3	Frankiales			2.7.7.80	ko:K21029	ko04122,map04122		R07459	RC00043	ko00000,ko00001,ko01000				Bacteria	2GMJI@201174,4ET5V@85013,COG0476@1,COG0476@2	NA|NA|NA	H	UBA THIF-type NAD FAD binding
MAG.T22.39_00269	1306174.JODP01000006_gene3759	3.6e-159	568.2	Actinobacteria													Bacteria	2GJQ6@201174,COG0661@1,COG0661@2	NA|NA|NA	S	unusual protein kinase
MAG.T22.39_00270	411468.CLOSCI_01808	4.6e-37	161.8	Lachnoclostridium				ko:K03406	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1UZ8R@1239,222QS@1506553,248ZT@186801,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T22.39_00271	196162.Noca_3312	8.7e-132	476.9	Actinobacteria	ampS			ko:K19689					ko00000,ko01000,ko01002				Bacteria	2INAN@201174,COG2309@1,COG2309@2	NA|NA|NA	E	Thermophilic metalloprotease (M29)
MAG.T22.39_00272	196162.Noca_3314	5.8e-117	427.2	Actinobacteria	sgcQ			ko:K06971					ko00000				Bacteria	2I8ZY@201174,COG0434@1,COG0434@2	NA|NA|NA	S	PFAM photosystem I assembly BtpA
MAG.T22.39_00273	196162.Noca_3315	2.1e-66	258.8	Actinobacteria	dhaK		2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878,ko:K05879	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2I5BZ@201174,COG2376@1,COG2376@2	NA|NA|NA	G	Dak2
MAG.T22.39_00274	196162.Noca_3316	1.9e-157	562.0	Propionibacteriales	dhaK		2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJV9@201174,4DN06@85009,COG2376@1,COG2376@2	NA|NA|NA	G	Dihydroxyacetone kinase
MAG.T22.39_00275	196162.Noca_3317	2.7e-112	412.1	Actinobacteria													Bacteria	2IEAP@201174,COG1172@1,COG1172@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
MAG.T22.39_00276	196162.Noca_3318	5.6e-125	454.1	Propionibacteriales				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	2GM6S@201174,4DP6N@85009,COG1172@1,COG1172@2	NA|NA|NA	G	Branched-chain amino acid transport system / permease component
MAG.T22.39_00277	196162.Noca_3319	3e-191	674.9	Propionibacteriales			3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	2GJ3F@201174,4DNG0@85009,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MAG.T22.39_00278	196162.Noca_3320	6.3e-151	540.4	Actinobacteria				ko:K02058,ko:K10559	ko02010,map02010	M00220,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.9			Bacteria	2I43Z@201174,COG1879@1,COG1879@2	NA|NA|NA	G	ABC transporter
MAG.T22.39_00279	196162.Noca_3321	4.4e-98	364.4	Propionibacteriales	sgcR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02081					ko00000,ko03000				Bacteria	2GMAJ@201174,4DUNF@85009,COG1349@1,COG1349@2	NA|NA|NA	K	DeoR C terminal sensor domain
MAG.T22.39_00281	656024.FsymDg_3207	1.2e-12	79.0	Actinobacteria													Bacteria	2DXVK@1,2GV2C@201174,346UP@2	NA|NA|NA		
MAG.T22.39_00282	1121924.ATWH01000016_gene3055	1e-104	387.1	Microbacteriaceae			2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Bacteria	2IH7C@201174,4FPFW@85023,COG3550@1,COG3550@2	NA|NA|NA	S	HipA-like C-terminal domain
MAG.T22.39_00283	1504319.GM45_3415	1.3e-31	142.9	Bacteria	bzrP			ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166				ko00000,ko00001,ko02000	9.A.24			Bacteria	COG3476@1,COG3476@2	NA|NA|NA	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MAG.T22.39_00285	1122998.AUHZ01000022_gene594	2.2e-79	302.8	Actinobacteria													Bacteria	2GKHI@201174,COG1397@1,COG1397@2	NA|NA|NA	O	PFAM ADP-ribosylation Crystallin J1
MAG.T22.39_00286	234621.RER_40450	4.9e-34	150.6	Nocardiaceae				ko:K09384					ko00000				Bacteria	2HNSJ@201174,4FWM8@85025,COG0507@1,COG0507@2,COG3410@1,COG3410@2	NA|NA|NA	L	Uncharacterized conserved protein (DUF2075)
MAG.T22.39_00287	1288494.EBAPG3_29580	3.8e-11	74.7	Betaproteobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1MX9Q@1224,2W20Q@28216,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM glycoside hydrolase family 39
MAG.T22.39_00288	1003195.SCAT_2309	3.6e-17	96.3	Actinobacteria				ko:K07451,ko:K07454					ko00000,ko01000,ko02048				Bacteria	2I4RE@201174,COG3440@1,COG3440@2	NA|NA|NA	V	Ubiquinol--cytochrome c reductase
MAG.T22.39_00289	593907.Celgi_2868	1.4e-104	386.7	Cellulomonadaceae	hpaIIM		2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036				Bacteria	2HY0D@201174,4F2AH@85016,COG0270@1,COG0270@2	NA|NA|NA	L	C-5 cytosine-specific DNA methylase
MAG.T22.39_00290	585531.HMPREF0063_10983	3.6e-97	362.8	Actinobacteria	Z012_07420		3.1.21.3,3.1.21.5	ko:K01153,ko:K01156					ko00000,ko01000,ko02048				Bacteria	2I36J@201174,COG0610@1,COG0610@2	NA|NA|NA	V	Z1 domain
MAG.T22.39_00291	585531.HMPREF0063_10984	1e-88	334.3	Bacteria													Bacteria	COG0323@1,COG0323@2	NA|NA|NA	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MAG.T22.39_00296	1206744.BAGL01000004_gene3541	6.5e-29	133.7	Nocardiaceae													Bacteria	2GSSC@201174,4G79B@85025,COG3636@1,COG3636@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_00297	452863.Achl_3344	1.2e-08	67.4	Actinobacteria			3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	2H6WE@201174,COG0265@1,COG0265@2	NA|NA|NA	O	Trypsin-like serine protease
MAG.T22.39_00301	1385520.N802_16465	2.4e-93	349.4	Intrasporangiaceae	hipA_2		2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Bacteria	2IH7C@201174,4FIBJ@85021,COG3550@1,COG3550@2	NA|NA|NA	S	Pfam:HipA_N
MAG.T22.39_00302	1125779.HMPREF1219_01454	1.1e-13	82.0	Corynebacteriaceae	hipB			ko:K15773					ko00000,ko02048,ko03000				Bacteria	22PKK@1653,2GYAA@201174,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_00303	1869.MB27_28275	3.3e-74	287.0	Actinobacteria				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GIRE@201174,COG1404@1,COG1404@2	NA|NA|NA	O	Belongs to the peptidase S8 family
MAG.T22.39_00304	1173024.KI912149_gene5789	8.5e-07	60.8	Stigonemataceae	ydeS	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141											Bacteria	1GK5W@1117,1JM8M@1189,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial transcriptional repressor C-terminal
MAG.T22.39_00305	561175.KB894095_gene2568	1.8e-18	99.4	Actinobacteria													Bacteria	2DMWY@1,2ISFN@201174,32U6G@2	NA|NA|NA		
MAG.T22.39_00306	31964.CMS0860	2.4e-09	69.3	Actinobacteria	hipB	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K07075,ko:K15773					ko00000,ko02048,ko03000				Bacteria	2I3WY@201174,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix
MAG.T22.39_00307	1394178.AWOO02000081_gene2198	1.6e-32	147.1	Streptosporangiales				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GM00@201174,4EFRW@85012,COG0683@1,COG0683@2	NA|NA|NA	E	Receptor family ligand binding region
MAG.T22.39_00308	1382356.JQMP01000003_gene2157	3.3e-138	498.8	Thermomicrobia				ko:K06978					ko00000				Bacteria	27YZ6@189775,2GA38@200795,COG2936@1,COG2936@2	NA|NA|NA	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
MAG.T22.39_00309	1108045.GORHZ_209_00310	7.5e-91	340.5	Actinobacteria													Bacteria	2GKED@201174,COG0179@1,COG0179@2	NA|NA|NA	Q	PFAM fumarylacetoacetate (FAA) hydrolase
MAG.T22.39_00310	1120950.KB892720_gene1872	1.1e-80	307.0	Propionibacteriales	gutB		1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKC7@201174,4DRTZ@85009,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T22.39_00311	1394178.AWOO02000018_gene6617	5.9e-84	317.8	Streptosporangiales	aspC		2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230		R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007				Bacteria	2GJ7R@201174,4EGQ9@85012,COG0436@1,COG0436@2	NA|NA|NA	E	DegT/DnrJ/EryC1/StrS aminotransferase family
MAG.T22.39_00312	1380347.JNII01000006_gene1663	2e-85	322.4	Frankiales	mshB		3.5.1.103	ko:K15525					ko00000,ko01000				Bacteria	2GKUM@201174,4ES8C@85013,COG2120@1,COG2120@2	NA|NA|NA	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway
MAG.T22.39_00314	1120950.KB892823_gene520	7.8e-88	331.6	Propionibacteriales	vanW												Bacteria	2GISH@201174,4DN8K@85009,COG2720@1,COG2720@2	NA|NA|NA	V	Putative peptidoglycan binding domain
MAG.T22.39_00315	2002.JOEQ01000007_gene1914	4.5e-133	481.5	Streptosporangiales	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2IDHB@201174,4EN5K@85012,COG0215@1,COG0215@2	NA|NA|NA	J	tRNA synthetases class I (C) catalytic domain
MAG.T22.39_00316	1048339.KB913029_gene32	4.3e-47	193.7	Frankiales	fdxA			ko:K05524					ko00000				Bacteria	2IKVN@201174,4ESV9@85013,COG1146@1,COG1146@2	NA|NA|NA	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein
MAG.T22.39_00317	1048339.KB913029_gene31	3.8e-116	424.9	Frankiales	dapC												Bacteria	2GJMI@201174,4ERPG@85013,COG0436@1,COG0436@2	NA|NA|NA	E	PFAM Aminotransferase class I and II
MAG.T22.39_00321	882083.SacmaDRAFT_4675	2.1e-52	212.6	Actinobacteria													Bacteria	2IAWJ@201174,COG2345@1,COG2345@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_00323	1385519.N801_18595	7.7e-26	123.2	Intrasporangiaceae													Bacteria	2IK6G@201174,4FH99@85021,COG3945@1,COG3945@2	NA|NA|NA	S	Hemerythrin HHE cation binding domain
MAG.T22.39_00324	33876.JNXY01000009_gene8951	1.2e-22	112.5	Micromonosporales	hcaC			ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002				Bacteria	2IQK7@201174,4DEJP@85008,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
MAG.T22.39_00325	35754.JNYJ01000033_gene2610	1.4e-29	135.6	Micromonosporales													Bacteria	2IQI4@201174,4DFMR@85008,COG1917@1,COG1917@2	NA|NA|NA	S	conserved protein, contains double-stranded beta-helix domain
MAG.T22.39_00326	298653.Franean1_6980	2e-20	105.5	Actinobacteria													Bacteria	2DW0B@1,2IKEK@201174,33XXM@2	NA|NA|NA		
MAG.T22.39_00327	365528.KB891230_gene1835	9.2e-12	76.3	Actinobacteria													Bacteria	2DMWY@1,2ISFN@201174,32U6G@2	NA|NA|NA		
MAG.T22.39_00328	1304865.JAGF01000001_gene1014	4e-30	138.7	Actinobacteria	kcsA			ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	2GKNF@201174,COG1226@1,COG1226@2	NA|NA|NA	P	Ion transport 2 domain protein
MAG.T22.39_00329	1504319.GM45_3455	8.5e-17	95.1	Bacteria			3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	COG0265@1,COG0265@2	NA|NA|NA	O	serine-type endopeptidase activity
MAG.T22.39_00331	397278.JOJN01000002_gene48	2.6e-51	208.8	Propionibacteriales				ko:K09952					ko00000,ko01000,ko02048				Bacteria	2I2MY@201174,4DWZY@85009,COG3513@1,COG3513@2	NA|NA|NA	L	Protein of unknown function (DUF1524)
MAG.T22.39_00332	269800.Tfu_1604	1.3e-153	549.7	Streptosporangiales	xylB		1.1.1.57,2.7.1.17	ko:K00040,ko:K00854,ko:K19168	ko00040,ko01100,map00040,map01100	M00014,M00061	R01639,R02454	RC00002,RC00085,RC00538	ko00000,ko00001,ko00002,ko01000,ko02048				Bacteria	2GJDZ@201174,4EFJC@85012,COG1070@1,COG1070@2	NA|NA|NA	G	FGGY family of carbohydrate kinases, N-terminal domain
MAG.T22.39_00333	351607.Acel_1129	1.3e-58	233.8	Frankiales	xylR												Bacteria	2GPEI@201174,4EX83@85013,COG1940@1,COG1940@2	NA|NA|NA	GK	PFAM ROK family protein
MAG.T22.39_00334	1172188.KB911822_gene1057	2.2e-117	429.5	Intrasporangiaceae													Bacteria	2GWA2@201174,2Z9VM@2,4FG2M@85021,COG1524@1	NA|NA|NA	S	mannose-ethanolamine phosphotransferase activity
MAG.T22.39_00335	266117.Rxyl_1038	8.1e-130	470.7	Rubrobacteria			4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GK3J@201174,4CPR5@84995,COG0076@1,COG0076@2	NA|NA|NA	E	Pyridoxal-dependent decarboxylase conserved domain
MAG.T22.39_00336	479432.Sros_7492	8.2e-112	410.6	Streptosporangiales			1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJKT@201174,4EMUF@85012,COG0446@1,COG0446@2	NA|NA|NA	S	Reductase C-terminal
MAG.T22.39_00337	312284.A20C1_13406	1.2e-15	88.6	Actinobacteria				ko:K05337					ko00000				Bacteria	2GWHY@201174,COG1141@1,COG1141@2	NA|NA|NA	C	Ferredoxin
MAG.T22.39_00338	312284.A20C1_13401	7.6e-139	500.0	unclassified Actinobacteria (class)			4.1.1.68	ko:K05921	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04134,R04380	RC01085,RC02669	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN2G@201174,3UWHK@52018,COG0179@1,COG0179@2	NA|NA|NA	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
MAG.T22.39_00339	1120949.KB903296_gene9417	9.9e-134	483.0	Actinobacteria													Bacteria	2GT9G@201174,COG3384@1,COG3384@2	NA|NA|NA	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase
MAG.T22.39_00340	312284.A20C1_13391	1.1e-203	716.1	unclassified Actinobacteria (class)	hpaE		1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85	ko:K00130,ko:K00151,ko:K10217	ko00260,ko00350,ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00260,map00350,map00362,map00380,map00622,map01100,map01120,map01220	M00038,M00533,M00555,M00569	R02565,R02566,R02762,R03889,R04418,R05353	RC00080,RC00218,RC00254	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,3UWFP@52018,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_00341	1348338.ADILRU_1945	1.1e-47	196.4	Actinobacteria	ywaE	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141											Bacteria	2IBDP@201174,COG1846@1,COG1846@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_00342	312284.A20C1_13381	7e-162	577.0	unclassified Actinobacteria (class)													Bacteria	2GKCG@201174,3UX3R@52018,COG2124@1,COG2124@2	NA|NA|NA	C	Cytochrome P450
MAG.T22.39_00343	312284.A20C1_13366	3e-66	258.5	unclassified Actinobacteria (class)	guaA1		6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	2GNA6@201174,3UXJK@52018,COG0518@1,COG0518@2	NA|NA|NA	F	Peptidase C26
MAG.T22.39_00344	312284.A20C1_13361	6.6e-166	590.5	unclassified Actinobacteria (class)			6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	2GJ2I@201174,3UWFH@52018,COG0174@1,COG0174@2	NA|NA|NA	E	glutamine synthetase
MAG.T22.39_00345	1341646.CBMO010000047_gene3798	7.2e-25	120.9	Mycobacteriaceae													Bacteria	2376K@1762,2GVGG@201174,COG1309@1,COG1309@2	NA|NA|NA	K	Tetracyclin repressor, C-terminal all-alpha domain
MAG.T22.39_00346	312284.A20C1_13351	1.4e-107	396.0	Actinobacteria													Bacteria	2I55Y@201174,COG4689@1,COG4689@2	NA|NA|NA	Q	acetoacetate decarboxylase
MAG.T22.39_00347	1394178.AWOO02000059_gene603	1.1e-106	393.3	Actinobacteria													Bacteria	2I9FZ@201174,COG2141@1,COG2141@2	NA|NA|NA	C	Luciferase-like monooxygenase
MAG.T22.39_00348	279238.Saro_2609	1.4e-77	297.0	Sphingomonadales			6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	1MU6V@1224,2KCZZ@204457,2U0Z2@28211,COG0174@1,COG0174@2	NA|NA|NA	E	Glutamine synthetase, catalytic domain
MAG.T22.39_00349	1380394.JADL01000002_gene1756	1.4e-91	343.2	Rhodospirillales	MA20_38180		1.13.11.9	ko:K18028	ko00760,ko01120,map00760,map01120	M00622	R09125	RC02430	ko00000,ko00001,ko00002,ko01000				Bacteria	1R4JS@1224,2JW5W@204441,2TRJ7@28211,COG2309@1,COG2309@2	NA|NA|NA	E	COG2309 Leucyl aminopeptidase (aminopeptidase T)
MAG.T22.39_00350	1121106.JQKB01000025_gene4092	1.2e-34	153.7	Alphaproteobacteria													Bacteria	1QZPD@1224,2TYBE@28211,COG2021@1,COG2021@2	NA|NA|NA	E	Serine aminopeptidase, S33
MAG.T22.39_00351	864051.BurJ1DRAFT_2505	9.8e-108	397.1	Betaproteobacteria	MA20_38160												Bacteria	1MW97@1224,2VHNT@28216,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase, C-terminal domain
MAG.T22.39_00352	67352.JODS01000009_gene7469	1.1e-180	639.8	Actinobacteria	badA		6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120		R00982	RC00004,RC00174	ko00000,ko00001,ko01000				Bacteria	2GJVK@201174,COG0365@1,COG0365@2	NA|NA|NA	I	Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MAG.T22.39_00353	1306174.JODP01000007_gene2424	2.5e-137	495.7	Actinobacteria													Bacteria	2I478@201174,COG0833@1,COG0833@2	NA|NA|NA	E	Amino acid permease
MAG.T22.39_00354	1386089.N865_00810	3.3e-44	186.0	Intrasporangiaceae				ko:K03449					ko00000,ko02000	2.A.1.17			Bacteria	2GP5W@201174,4FFXQ@85021,COG2807@1,COG2807@2	NA|NA|NA	P	MFS transporter
MAG.T22.39_00355	1240349.ANGC01000016_gene774	9.6e-87	327.4	Nocardiaceae			1.14.13.141	ko:K15981	ko00984,ko01120,map00984,map01120		R09859,R11357	RC01216,RC03368	ko00000,ko00001,ko00199,ko01000				Bacteria	2GKCG@201174,4FZ1Q@85025,COG2124@1,COG2124@2	NA|NA|NA	C	Belongs to the cytochrome P450 family
MAG.T22.39_00356	164757.Mjls_3416	7.1e-53	214.5	Mycobacteriaceae	sadh		1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	237XV@1762,2GKNW@201174,COG1064@1,COG1064@2	NA|NA|NA	S	alcohol dehydrogenase
MAG.T22.39_00357	994479.GL877882_gene6778	3.6e-68	265.8	Pseudonocardiales	ipuC		6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	2GM3K@201174,4DXD6@85010,COG0174@1,COG0174@2	NA|NA|NA	E	Glutamine synthetase, catalytic domain
MAG.T22.39_00358	312284.A20C1_13366	1.4e-29	136.7	unclassified Actinobacteria (class)	guaA1		6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	2GNA6@201174,3UXJK@52018,COG0518@1,COG0518@2	NA|NA|NA	F	Peptidase C26
MAG.T22.39_00359	67332.FM21_02815	5.2e-95	354.8	Actinobacteria	frc_4		2.8.3.22	ko:K18289	ko00660,map00660		R02407,R03154	RC00014	ko00000,ko00001,ko01000				Bacteria	2GIU7@201174,COG1804@1,COG1804@2	NA|NA|NA	C	L-carnitine dehydratase bile acid-inducible protein F
MAG.T22.39_00360	469383.Cwoe_5073	6.9e-148	530.4	Rubrobacteria	MA20_04510		1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNFB@201174,4CPM4@84995,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase, C-terminal domain
MAG.T22.39_00361	66874.JOFS01000005_gene3800	4.3e-158	564.7	Actinobacteria	puuC		1.2.1.3,1.2.1.99	ko:K00128,ko:K09472	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00136	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R07417,R07418,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_00362	1120950.KB892789_gene63	5.4e-44	184.5	Actinobacteria													Bacteria	2GKPP@201174,COG1802@1,COG1802@2	NA|NA|NA	K	PFAM regulatory protein GntR HTH
MAG.T22.39_00363	1504319.GM45_3460	1.9e-66	259.6	unclassified Actinobacteria (class)													Bacteria	2GKVT@201174,3UXF9@52018,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_00364	675635.Psed_1025	4e-127	461.5	Pseudonocardiales	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.11,2.4.1.342	ko:K16148,ko:K16150	ko00500,ko01100,map00500,map01100		R00292,R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT4		Bacteria	2I2EE@201174,4E0K3@85010,COG0297@1,COG0297@2	NA|NA|NA	G	Glycosyl transferase 4-like domain
MAG.T22.39_00365	211114.JOEF01000002_gene4539	2.5e-156	558.5	Pseudonocardiales	glgC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2768	Bacteria	2I2EF@201174,4DYPJ@85010,COG0448@1,COG0448@2	NA|NA|NA	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAG.T22.39_00366	316274.Haur_0516	1.3e-36	161.0	Chloroflexia			3.4.21.4	ko:K01312	ko04080,ko04972,ko04974,ko05164,map04080,map04972,map04974,map05164				ko00000,ko00001,ko01000,ko01002,ko04147				Bacteria	2G7WH@200795,375SR@32061,COG5640@1,COG5640@2	NA|NA|NA	O	PFAM peptidase S1 and S6, chymotrypsin Hap
MAG.T22.39_00367	1203568.HMPREF1484_00319	2.3e-53	216.1	Actinobacteria	mutT		3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000,ko03400				Bacteria	2GNRV@201174,COG0494@1,COG0494@2	NA|NA|NA	L	Belongs to the NUDIX hydrolase family
MAG.T22.39_00368	1304865.JAGF01000001_gene2382	6.8e-82	311.6	Actinobacteria													Bacteria	2GJZH@201174,COG5607@1,COG5607@2	NA|NA|NA	S	CHAD domain containing protein
MAG.T22.39_00369	1449347.JQLN01000005_gene4167	8.8e-274	949.5	Kitasatospora	ppk		2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GJ0B@201174,2M17V@2063,COG0855@1,COG0855@2	NA|NA|NA	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MAG.T22.39_00370	1121272.KB903250_gene3179	9e-85	320.5	Micromonosporales	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189,2.7.4.1	ko:K00937,ko:K15520	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GM35@201174,4D8MC@85008,COG0454@1,COG0456@2	NA|NA|NA	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol
MAG.T22.39_00371	1463857.JOFZ01000009_gene6294	4.4e-79	301.2	Actinobacteria													Bacteria	2GJGU@201174,COG0745@1,COG0745@2	NA|NA|NA	KT	transcriptional
MAG.T22.39_00372	1463855.JOHV01000033_gene1326	6.1e-45	187.2	Actinobacteria				ko:K16786,ko:K16787	ko02010,map02010	M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2I2Y2@201174,COG3845@1,COG3845@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
MAG.T22.39_00373	1385519.N801_00130	3.6e-82	311.6	Intrasporangiaceae				ko:K16784,ko:K16785,ko:K16786,ko:K16787,ko:K16927	ko02010,map02010	M00581,M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	2GMK1@201174,4FF62@85021,COG1122@1,COG1122@2	NA|NA|NA	P	ABC transporter (Permease)
MAG.T22.39_00374	1445613.JALM01000010_gene2261	1.9e-15	89.7	Pseudonocardiales	cobT		2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2207	Bacteria	2GJ16@201174,4DX78@85010,COG2038@1,COG2038@2	NA|NA|NA	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
MAG.T22.39_00375	1429046.RR21198_3448	1.4e-113	416.4	Nocardiaceae	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ47@201174,4FXI6@85025,COG0404@1,COG0404@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine
MAG.T22.39_00376	66373.JOFQ01000007_gene3440	4.7e-128	464.9	Actinobacteria	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJRB@201174,COG0260@1,COG0260@2	NA|NA|NA	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MAG.T22.39_00377	1043493.BBLU01000001_gene706	2.1e-196	691.8	Actinobacteria	lpdA		1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GIXY@201174,COG1249@1,COG1249@2	NA|NA|NA	C	Dehydrogenase
MAG.T22.39_00378	1380356.JNIK01000021_gene4508	2.6e-156	558.9	Frankiales	sucB		2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GMUV@201174,4ERCG@85013,COG0508@1,COG0508@2	NA|NA|NA	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component
MAG.T22.39_00379	1288079.AUKN01000003_gene3733	6e-99	367.5	Actinobacteria		GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652		ko:K07071					ko00000				Bacteria	2GJS0@201174,COG1090@1,COG1090@2	NA|NA|NA	S	epimerase
MAG.T22.39_00380	208444.JNYY01000012_gene7819	1.6e-81	310.1	Pseudonocardiales	hemY												Bacteria	2I3QR@201174,4DZ1J@85010,COG1232@1,COG1232@2	NA|NA|NA	H	Flavin containing amine oxidoreductase
MAG.T22.39_00381	1184609.KILIM_016_00110	2.3e-79	302.0	Dermatophilaceae	lipB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100		R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000				Bacteria	2GJIX@201174,4F6I7@85018,COG0321@1,COG0321@2	NA|NA|NA	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
MAG.T22.39_00382	298654.FraEuI1c_1754	2.8e-142	511.5	Frankiales	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100		R07767,R07768	RC01978	ko00000,ko00001,ko01000				Bacteria	2GKD4@201174,4ERG6@85013,COG0320@1,COG0320@2	NA|NA|NA	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MAG.T22.39_00383	644107.SL1157_0198	6.9e-26	124.0	Ruegeria	yuaD												Bacteria	1RAAN@1224,28NII@1,2U5W9@28211,2ZBJY@2,4NC22@97050	NA|NA|NA	S	Mosc domain protein
MAG.T22.39_00384	1288079.AUKN01000003_gene3761	3.5e-43	181.8	Actinobacteria													Bacteria	2DBPK@1,2I87Y@201174,2ZA9M@2	NA|NA|NA	S	Domain of unknown function (DUF4191)
MAG.T22.39_00386	1382306.JNIM01000001_gene2431	6.2e-64	251.1	Chloroflexi	MA20_14290		1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100		R05066	RC00099	ko00000,ko00001,ko01000				Bacteria	2G8RG@200795,COG2084@1,COG2084@2	NA|NA|NA	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding
MAG.T22.39_00388	1464048.JNZS01000011_gene5001	5.2e-128	464.5	Micromonosporales	kynU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJQ@201174,4DBYN@85008,COG3844@1,COG3844@2	NA|NA|NA	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively
MAG.T22.39_00389	2002.JOEQ01000010_gene6368	1.5e-10	73.6	Streptosporangiales			2.7.11.1,3.2.1.4	ko:K01179,ko:K12567,ko:K20276	ko00500,ko01100,ko02024,ko05410,ko05414,map00500,map01100,map02024,map05410,map05414		R06200,R11307,R11308		ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812		GH5,GH9		Bacteria	2I8F1@201174,4EKYK@85012,COG1361@1,COG1361@2,COG3468@1,COG3468@2,COG4719@1,COG4719@2,COG4733@1,COG4733@2	NA|NA|NA	M	Putative Ig domain
MAG.T22.39_00390	284031.JNXD01000045_gene7247	1.7e-41	176.4	Actinobacteria			5.4.99.28,5.4.99.29	ko:K06177,ko:K07052					ko00000,ko01000,ko03009,ko03016				Bacteria	2GKRA@201174,COG1266@1,COG1266@2	NA|NA|NA	S	Abortive infection protein
MAG.T22.39_00391	471853.Bcav_0814	6.2e-29	133.7	Actinobacteria													Bacteria	2CUM0@1,2IQG7@201174,32SVJ@2	NA|NA|NA	S	Protein of unknown function (DUF3263)
MAG.T22.39_00392	1150864.MILUP08_46579	1.1e-250	872.5	Micromonosporales	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	2GKC9@201174,4D901@85008,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MAG.T22.39_00393	1121272.KB903250_gene2644	4.1e-154	550.8	Micromonosporales	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147				Bacteria	2GK2Q@201174,4DA79@85008,COG0499@1,COG0499@2	NA|NA|NA	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MAG.T22.39_00394	1120934.KB894404_gene550	6.6e-136	490.7	Pseudonocardiales													Bacteria	2GMZX@201174,4DZWQ@85010,COG2826@1,COG2826@2	NA|NA|NA	L	PFAM Integrase, catalytic core
MAG.T22.39_00395	1521187.JPIM01000002_gene3162	8.7e-66	257.3	Chloroflexi	mmuM	GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000				Bacteria	2G7VY@200795,COG2040@1,COG2040@2	NA|NA|NA	E	Homocysteine S-methyltransferase
MAG.T22.39_00396	1032480.MLP_00530	6.5e-117	427.6	Propionibacteriales	pit			ko:K03306					ko00000	2.A.20			Bacteria	2GJHK@201174,4DND5@85009,COG0306@1,COG0306@2	NA|NA|NA	P	Phosphate transporter family
MAG.T22.39_00397	1120950.KB892739_gene3970	1.2e-23	117.1	Actinobacteria				ko:K07052					ko00000				Bacteria	2IFZI@201174,COG1266@1,COG1266@2	NA|NA|NA	S	metal-dependent membrane protease
MAG.T22.39_00398	1306174.JODP01000001_gene4625	1.9e-100	372.1	Actinobacteria													Bacteria	2GJE6@201174,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulator receiver
MAG.T22.39_00399	443255.SCLAV_2101	2.1e-137	496.1	Actinobacteria	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K02484,ko:K07653,ko:K07654	ko02020,map02020	M00460,M00461			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2GJ2D@201174,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_00400	269800.Tfu_2494	2.4e-67	263.5	Streptosporangiales	lpqB												Bacteria	2GJ5Y@201174,4EJ8G@85012,COG5401@1,COG5401@2	NA|NA|NA	S	Sporulation and spore germination
MAG.T22.39_00401	471852.Tcur_4040	2.7e-15	89.0	Streptosporangiales	ctsW		3.6.4.12	ko:K02242,ko:K03654	ko03018,map03018	M00429			ko00000,ko00001,ko00002,ko01000,ko02044,ko03400				Bacteria	2I9PA@201174,4EJN7@85012,COG1040@1,COG1040@2	NA|NA|NA	S	Phosphoribosyl transferase domain
MAG.T22.39_00402	1123320.KB889749_gene4542	0.0	1288.5	Actinobacteria	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680		ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	2GIRT@201174,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MAG.T22.39_00403	471853.Bcav_1253	1.1e-14	87.0	Actinobacteria													Bacteria	2DPN9@1,2GRGX@201174,332RH@2	NA|NA|NA		
MAG.T22.39_00405	1095772.CAHH01000073_gene569	2.6e-21	107.8	Actinobacteria													Bacteria	2GR98@201174,COG3311@1,COG3311@2	NA|NA|NA	K	DNA binding domain, excisionase family
MAG.T22.39_00406	351607.Acel_1753	9.3e-29	134.0	Frankiales													Bacteria	2GR8T@201174,4EXDF@85013,COG1261@1,COG1261@2	NA|NA|NA	NO	PFAM SAF domain protein
MAG.T22.39_00407	1211815.CBYP010000043_gene3439	3.7e-35	156.0	Frankiales													Bacteria	2IARP@201174,4ERDT@85013,COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T22.39_00408	1313172.YM304_34950	1.4e-18	100.1	Actinobacteria													Bacteria	2IIU7@201174,COG1376@1,COG1376@2	NA|NA|NA	S	ErfK ybiS ycfS ynhG family protein
MAG.T22.39_00409	479433.Caci_7582	6.3e-61	241.5	Actinobacteria				ko:K07001					ko00000				Bacteria	2IB0F@201174,COG1752@1,COG1752@2	NA|NA|NA	S	esterase of the alpha-beta hydrolase superfamily
MAG.T22.39_00410	1306174.JODP01000033_gene7248	1.9e-15	89.4	Bacteria													Bacteria	COG3832@1,COG3832@2	NA|NA|NA	J	glyoxalase III activity
MAG.T22.39_00411	981369.JQMJ01000004_gene2898	0.0	1602.0	Streptacidiphilus	gdhB	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100		R00243	RC00006,RC02799	ko00000,ko00001,ko01000				Bacteria	2GK0C@201174,2NEHI@228398,COG2902@1,COG2902@2	NA|NA|NA	E	Bacterial NAD-glutamate dehydrogenase
MAG.T22.39_00412	1894.JOER01000030_gene503	1.6e-176	625.5	Actinobacteria	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11,3.1.2.6	ko:K01069,ko:K21029,ko:K21147	ko00620,ko04122,map00620,map04122		R01736,R07459,R07461	RC00004,RC00043,RC00137	ko00000,ko00001,ko01000				Bacteria	2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2	NA|NA|NA	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are
MAG.T22.39_00414	756272.Plabr_2175	3.2e-82	312.0	Planctomycetes													Bacteria	2IYBZ@203682,COG1216@1,COG1216@2	NA|NA|NA	S	involved in cell wall biogenesis
MAG.T22.39_00416	1121877.JQKF01000003_gene1570	2.7e-09	67.8	Acidimicrobiia				ko:K02071	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24			Bacteria	2HH1B@201174,4CP1I@84992,COG1135@1,COG1135@2	NA|NA|NA	P	NIL
MAG.T22.39_00417	28444.JODQ01000008_gene1197	1e-140	507.7	Streptosporangiales													Bacteria	2GMAV@201174,4EHD3@85012,COG0392@1,COG0392@2	NA|NA|NA	I	Lysylphosphatidylglycerol synthase TM region
MAG.T22.39_00419	105422.BBPM01000032_gene3626	2e-86	325.9	Streptacidiphilus	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.241,2.3.1.265	ko:K02517,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2GM7B@201174,2NF22@228398,COG1560@1,COG1560@2	NA|NA|NA	M	Bacterial lipid A biosynthesis acyltransferase
MAG.T22.39_00420	356851.JOAN01000007_gene4051	1.7e-36	159.5	Micromonosporales	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070		R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000				Bacteria	2GYKW@201174,4DCRP@85008,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T22.39_00421	1123320.KB889665_gene1375	1.6e-17	97.1	Actinobacteria	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944		ko:K02355					ko00000,ko03012,ko03029				Bacteria	2GKRU@201174,COG0480@1,COG0480@2	NA|NA|NA	J	elongation factor G
MAG.T22.39_00422	285514.JNWO01000028_gene2381	8e-64	250.0	Actinobacteria	hit	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230		R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000				Bacteria	2GJT5@201174,COG0537@1,COG0537@2	NA|NA|NA	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MAG.T22.39_00423	1169161.KB897725_gene1727	2.2e-279	968.0	Actinobacteria	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GKTC@201174,COG0441@1,COG0441@2	NA|NA|NA	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAG.T22.39_00425	1323361.JPOC01000092_gene989	7e-10	72.4	Nocardiaceae	psrP1			ko:K12548,ko:K13735	ko05100,map05100				ko00000,ko00001				Bacteria	2HDZF@201174,4FVZW@85025,COG2373@1,COG2373@2	NA|NA|NA	S	Bacterial Ig-like domain (group 3)
MAG.T22.39_00426	1449346.JQMO01000002_gene1135	2.1e-77	295.8	Kitasatospora			2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GN5Z@201174,2M2BV@2063,COG0115@1,COG0115@2	NA|NA|NA	EH	Amino-transferase class IV
MAG.T22.39_00427	1123319.AUBE01000017_gene4689	4.5e-70	271.2	Actinobacteria	pabB		2.6.1.85,4.1.3.27,4.1.3.38	ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GN7D@201174,COG0147@1,COG0147@2	NA|NA|NA	EH	PFAM chorismate
MAG.T22.39_00428	1032480.MLP_10970	7.5e-12	75.1	Propionibacteriales	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02946	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHRA@201174,4DQJR@85009,COG0051@1,COG0051@2	NA|NA|NA	J	Involved in the binding of tRNA to the ribosomes
MAG.T22.39_00429	1157632.AQWQ01000002_gene4414	1.2e-85	322.8	Actinobacteria	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234		ko:K02906	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJXT@201174,COG0087@1,COG0087@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MAG.T22.39_00430	1068980.ARVW01000001_gene2513	1e-82	313.2	Pseudonocardiales	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02926	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJYJ@201174,4DXQB@85010,COG0088@1,COG0088@2	NA|NA|NA	J	Forms part of the polypeptide exit tunnel
MAG.T22.39_00431	1048339.KB913029_gene2752	9.3e-36	156.0	Frankiales	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02892	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ7V@201174,4ET1Y@85013,COG0089@1,COG0089@2	NA|NA|NA	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MAG.T22.39_00432	1095772.CAHH01000006_gene2255	1.4e-142	512.3	Actinobacteria	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02886	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GK7R@201174,COG0090@1,COG0090@2	NA|NA|NA	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MAG.T22.39_00433	1288083.AUKR01000012_gene663	8e-42	176.0	Actinobacteria	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02965	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKMS@201174,COG0185@1,COG0185@2	NA|NA|NA	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MAG.T22.39_00434	1123320.KB889574_gene5569	1.9e-39	169.1	Actinobacteria	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02890	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IM3J@201174,COG0091@1,COG0091@2	NA|NA|NA	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MAG.T22.39_00435	1386089.N865_03705	1.6e-90	339.3	Intrasporangiaceae	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02982	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GKF1@201174,4FF4N@85021,COG0092@1,COG0092@2	NA|NA|NA	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MAG.T22.39_00436	1380346.JNIH01000003_gene2048	2.4e-66	258.1	Actinobacteria	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02878	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFEI@201174,COG0197@1,COG0197@2	NA|NA|NA	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MAG.T22.39_00437	67257.JODR01000016_gene4726	4.5e-22	110.2	Actinobacteria	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02904	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ6V@201174,COG0255@1,COG0255@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uL29 family
MAG.T22.39_00438	2074.JNYD01000012_gene265	3.2e-35	154.1	Pseudonocardiales	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02961	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ68@201174,4E5MJ@85010,COG0186@1,COG0186@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MAG.T22.39_00439	1380354.JIAN01000005_gene1442	2.1e-58	231.5	Cellulomonadaceae	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02874	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHNX@201174,4F2CC@85016,COG0093@1,COG0093@2	NA|NA|NA	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MAG.T22.39_00440	1504319.GM45_2595	7.1e-35	153.3	unclassified Actinobacteria (class)	rplX	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02895	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKP2@201174,3UWYV@52018,COG0198@1,COG0198@2	NA|NA|NA	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MAG.T22.39_00441	1229203.KI301992_gene2089	6.9e-85	320.1	unclassified Actinobacteria (class)	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02931	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJW7@201174,3UW6C@52018,COG0094@1,COG0094@2	NA|NA|NA	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MAG.T22.39_00442	1386089.N865_03740	4.2e-23	113.2	Intrasporangiaceae	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02954	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ8R@201174,4FH9A@85021,COG0199@1,COG0199@2	NA|NA|NA	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MAG.T22.39_00443	1123065.ATWL01000003_gene899	7.3e-57	226.5	Actinobacteria	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02994	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHQZ@201174,COG0096@1,COG0096@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MAG.T22.39_00444	590998.Celf_1016	8.7e-69	266.5	Cellulomonadaceae	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02933	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GK35@201174,4F206@85016,COG0097@1,COG0097@2	NA|NA|NA	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MAG.T22.39_00445	743718.Isova_0673	1.6e-40	172.2	Promicromonosporaceae	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02881	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKTX@201174,4F4HX@85017,COG0256@1,COG0256@2	NA|NA|NA	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MAG.T22.39_00446	285535.JOEY01000072_gene963	8.9e-83	313.2	Actinobacteria	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02988	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJW8@201174,COG0098@1,COG0098@2	NA|NA|NA	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MAG.T22.39_00447	1385520.N802_08000	3.1e-18	97.1	Intrasporangiaceae	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02907	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQV0@201174,4FHRR@85021,COG1841@1,COG1841@2	NA|NA|NA	J	Ribosomal protein L30
MAG.T22.39_00448	1298863.AUEP01000004_gene2153	2e-55	221.9	Propionibacteriales	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02876	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2II6M@201174,4DQND@85009,COG0200@1,COG0200@2	NA|NA|NA	J	binds to the 23S rRNA
MAG.T22.39_00449	1504319.GM45_2550	3.7e-166	591.3	unclassified Actinobacteria (class)	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944		ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5			Bacteria	2GJ26@201174,3UWEW@52018,COG0201@1,COG0201@2	NA|NA|NA	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MAG.T22.39_00450	1123065.ATWL01000003_gene906	3.5e-68	264.6	Actinobacteria	adk		2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJ7T@201174,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MAG.T22.39_00451	408672.NBCG_03653	2.1e-87	328.9	Propionibacteriales	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	2GKKB@201174,4DNQ9@85009,COG0024@1,COG0024@2	NA|NA|NA	J	Methionine aminopeptidase
MAG.T22.39_00452	1304865.JAGF01000001_gene1642	1.2e-26	126.3	Bacteria													Bacteria	2EC90@1,3367D@2	NA|NA|NA		
MAG.T22.39_00453	446469.Sked_00270	1.4e-52	213.0	Actinobacteria			2.7.1.83	ko:K16328	ko00240,map00240		R03315	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2I6CS@201174,COG1846@1,COG1846@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_00454	269800.Tfu_2622	9.1e-33	145.6	Streptosporangiales	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065		ko:K02518					ko00000,ko03012				Bacteria	2IQ4B@201174,4EK2Q@85012,COG0361@1,COG0361@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MAG.T22.39_00455	471853.Bcav_3116	9.1e-13	78.2	Actinobacteria	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02919	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GWMH@201174,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
MAG.T22.39_00456	351607.Acel_0331	1.8e-49	201.8	Frankiales	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02952	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHPN@201174,4ESIQ@85013,COG0099@1,COG0099@2	NA|NA|NA	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MAG.T22.39_00457	1385520.N802_07900	4.3e-57	227.3	Intrasporangiaceae	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02948	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFFC@201174,4FGCQ@85021,COG0100@1,COG0100@2	NA|NA|NA	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MAG.T22.39_00459	1032480.MLP_31830	2e-170	606.7	Propionibacteriales	uvrD		3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJD0@201174,4DPY8@85009,COG0210@1,COG0210@2,COG2887@1,COG2887@2	NA|NA|NA	L	Belongs to the helicase family. UvrD subfamily
MAG.T22.39_00460	1048339.KB913029_gene2921	7.7e-210	737.6	Frankiales	uvrD2		3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GM2E@201174,4ES9T@85013,COG0210@1,COG0210@2,COG2887@1,COG2887@2	NA|NA|NA	L	Belongs to the helicase family. UvrD subfamily
MAG.T22.39_00461	1265310.CCBD010000007_gene3135	8.5e-46	191.4	Mycobacteriaceae													Bacteria	2345V@1762,2HNA8@201174,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase
MAG.T22.39_00462	1120950.KB892749_gene3362	4.3e-65	255.0	Propionibacteriales	nudC		3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000				Bacteria	2GJZY@201174,4DN72@85009,COG2816@1,COG2816@2	NA|NA|NA	L	NUDIX domain
MAG.T22.39_00463	219305.MCAG_01886	3.7e-23	114.8	Micromonosporales	grxA		1.20.4.3	ko:K18917					ko00000,ko01000				Bacteria	2IQF9@201174,4DEXP@85008,COG0695@1,COG0695@2	NA|NA|NA	O	Glutaredoxin
MAG.T22.39_00464	1089552.KI911559_gene165	8.9e-50	203.8	Rhodospirillales	ybhL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06890					ko00000				Bacteria	1MU69@1224,2JRZ2@204441,2TRSF@28211,COG0670@1,COG0670@2	NA|NA|NA	S	Belongs to the BI1 family
MAG.T22.39_00465	570967.JMLV01000002_gene1653	1.6e-27	128.6	Rhodospirillales	phhB		4.2.1.96	ko:K01724	ko00790,map00790		R04734	RC01208	ko00000,ko00001,ko01000,ko04147				Bacteria	1MZ5Q@1224,2JU2A@204441,2UBWN@28211,COG2154@1,COG2154@2	NA|NA|NA	H	pterin-4-alpha-carbinolamine dehydratase
MAG.T22.39_00466	1437448.AZRT01000037_gene3033	1.2e-49	203.0	Brucellaceae	ligT		3.1.4.58	ko:K01975					ko00000,ko01000,ko03016				Bacteria	1J2TP@118882,1RDB2@1224,2U7FV@28211,COG1514@1,COG1514@2	NA|NA|NA	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MAG.T22.39_00467	1125973.JNLC01000015_gene3328	4e-57	228.0	Bradyrhizobiaceae	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Bacteria	1RCXZ@1224,2U74E@28211,3JQRR@41294,COG2755@1,COG2755@2	NA|NA|NA	E	GDSL-like Lipase/Acylhydrolase
MAG.T22.39_00468	1333998.M2A_0734	2.7e-54	218.4	unclassified Alphaproteobacteria	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MXG9@1224,2TS0J@28211,4BPZJ@82117,COG4181@1,COG4181@2	NA|NA|NA	Q	ABC transporter
MAG.T22.39_00469	1227739.Hsw_2779	5.9e-37	160.6	Cytophagia													Bacteria	47PID@768503,4NK0K@976,COG1216@1,COG1216@2	NA|NA|NA	S	Psort location Cytoplasmic, score
MAG.T22.39_00470	345341.KUTG_05018	6.7e-17	93.6	Pseudonocardiales	XK27_09090			ko:K09153					ko00000				Bacteria	2GQZ0@201174,4E5TW@85010,COG2456@1,COG2456@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2304)
MAG.T22.39_00471	1179773.BN6_01620	6.5e-64	250.8	Pseudonocardiales	ycbB			ko:K00786					ko00000,ko01000				Bacteria	2I2J1@201174,4DXD3@85010,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T22.39_00472	710687.KI912270_gene2442	3.7e-113	414.8	Mycobacteriaceae	rfbG		4.2.1.45	ko:K01709	ko00520,map00520		R02426	RC00402	ko00000,ko00001,ko01000				Bacteria	238A2@1762,2I2ZM@201174,COG0451@1,COG0451@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
MAG.T22.39_00475	1121106.JQKB01000024_gene5023	1.4e-15	90.9	Alphaproteobacteria													Bacteria	1RH3G@1224,2U9RB@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T22.39_00476	1408418.JNJH01000020_gene925	6.9e-69	269.2	Alphaproteobacteria													Bacteria	1N5HW@1224,2U1Q7@28211,COG0438@1,COG0438@2	NA|NA|NA	M	glycosyl transferase group 1
MAG.T22.39_00477	1123052.AUDF01000005_gene993	1.9e-58	233.0	Microbacteriaceae	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	2GNMA@201174,4FKP2@85023,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T22.39_00478	378753.KRH_20460	6.9e-136	490.3	Micrococcaceae	gmd		4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	1W83A@1268,2GNMA@201174,COG1089@1,COG1089@2	NA|NA|NA	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MAG.T22.39_00480	1123258.AQXZ01000010_gene3746	8.8e-37	161.0	Bacteria			2.4.1.268,2.4.1.83	ko:K00721,ko:K07011,ko:K12990,ko:K14597,ko:K21349	ko00510,ko00906,ko01100,ko02024,ko02025,map00510,map00906,map01100,map02024,map02025		R01009,R07544,R07546	RC00005,RC00262	ko00000,ko00001,ko01000,ko01003,ko01005		GT2,GT81		Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T22.39_00481	477641.MODMU_4707	6.2e-117	427.2	Frankiales	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0334	Bacteria	2GP20@201174,4ETV6@85013,COG1209@1,COG1209@2	NA|NA|NA	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MAG.T22.39_00482	316058.RPB_3231	8.4e-38	165.2	Alphaproteobacteria													Bacteria	1MYGG@1224,2DM0M@1,2UA4C@28211,3175D@2	NA|NA|NA		
MAG.T22.39_00483	1828.JOKB01000014_gene3143	4.8e-23	115.2	Nocardiaceae		GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K00786					ko00000,ko01000				Bacteria	2IK5X@201174,4G0HH@85025,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T22.39_00485	666685.R2APBS1_0578	9.6e-50	204.9	Xanthomonadales													Bacteria	1QCCE@1224,1T824@1236,1XA26@135614,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T22.39_00486	98439.AJLL01000033_gene3200	1.2e-98	367.5	Stigonemataceae				ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	1G2HS@1117,1JK8Z@1189,COG1215@1,COG1215@2,COG1216@1,COG1216@2	NA|NA|NA	M	Glycosyltransferase like family
MAG.T22.39_00487	351607.Acel_0421	7.7e-89	334.3	Frankiales			3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103			Bacteria	2GIVF@201174,4ESAJ@85013,COG1134@1,COG1134@2	NA|NA|NA	GM	PFAM ABC transporter related
MAG.T22.39_00488	351607.Acel_0420	6.5e-36	157.9	Frankiales	rgpC			ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GP5K@201174,4ESU0@85013,COG1682@1,COG1682@2	NA|NA|NA	GM	Transport permease protein
MAG.T22.39_00489	1121106.JQKB01000045_gene2998	4.6e-45	189.5	Alphaproteobacteria													Bacteria	1RGME@1224,2U7Z1@28211,COG0438@1,COG0438@2,COG0457@1,COG0457@2	NA|NA|NA	M	glycosyl transferase group 1
MAG.T22.39_00491	1323361.JPOC01000092_gene988	2.2e-06	60.5	Bacteria													Bacteria	COG3391@1,COG3391@2	NA|NA|NA	CO	amine dehydrogenase activity
MAG.T22.39_00492	1151061.CAJY01000013_gene38	1.8e-25	123.6	Actinobacteria													Bacteria	2IP14@201174,COG4645@1,COG4645@2	NA|NA|NA	S	OpgC protein
MAG.T22.39_00493	1157708.KB907459_gene2119	1.6e-24	120.2	Betaproteobacteria	rgpB												Bacteria	1QVA8@1224,2WHEZ@28216,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T22.39_00494	446465.Bfae_02940	2.2e-98	365.9	Dermabacteraceae	rgpA			ko:K12996					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	2IBM0@201174,4FDEP@85020,COG0438@1,COG0438@2	NA|NA|NA	M	Domain of unknown function (DUF1972)
MAG.T22.39_00495	1203568.HMPREF1484_02143	5.1e-68	265.8	Dermabacteraceae				ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2HXAQ@201174,4FCEY@85020,COG1132@1,COG1132@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T22.39_00496	1120950.KB892756_gene6682	1.3e-68	266.2	Propionibacteriales	rmlC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3465	Bacteria	2GMW4@201174,4DUK2@85009,COG1898@1,COG1898@2	NA|NA|NA	M	dTDP-4-dehydrorhamnose 3,5-epimerase
MAG.T22.39_00498	110319.CF8_3326	6.6e-42	179.1	Bacteria			2.1.1.107,2.1.1.294,2.7.1.181,2.7.11.1	ko:K02496,ko:K05802,ko:K08884,ko:K18827	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194,R10657,R10658	RC00002,RC00003,RC00078,RC00871,RC03220	ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko02000	1.A.23.1.1			Bacteria	COG2959@1,COG2959@2	NA|NA|NA	H	enzyme of heme biosynthesis
MAG.T22.39_00499	710111.FraQA3DRAFT_2947	1.7e-88	333.6	Frankiales	wbaP		2.7.8.6	ko:K00996					ko00000,ko01000,ko01005				Bacteria	2GK0M@201174,4ES81@85013,COG1086@1,COG1086@2,COG2148@1,COG2148@2	NA|NA|NA	M	PFAM sugar transferase
MAG.T22.39_00500	1173027.Mic7113_0392	8.9e-43	181.4	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T22.39_00501	1173027.Mic7113_0392	1.7e-38	167.2	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T22.39_00502	42256.RradSPS_1173	2.2e-38	166.0	Rubrobacteria	phcB		2.1.1.295,2.1.1.79	ko:K00574,ko:K12240,ko:K18534,ko:K19620,ko:K20444	ko00130,ko01053,ko01100,ko01110,ko02020,map00130,map01053,map01100,map01110,map02020	M00112	R07501,R10709,R10710	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000,ko01005,ko01008,ko02000	4.D.1.3	GT2,GT4		Bacteria	2HQ25@201174,4CRII@84995,COG0500@1,COG0500@2	NA|NA|NA	Q	Methyltransferase domain
MAG.T22.39_00503	1306174.JODP01000021_gene222	2.9e-114	419.5	Actinobacteria													Bacteria	2GKI5@201174,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase
MAG.T22.39_00504	1193181.BN10_1120002	2.4e-44	186.8	Actinobacteria													Bacteria	2E19N@1,2IF2A@201174,32WPX@2	NA|NA|NA	S	Predicted membrane protein (DUF2142)
MAG.T22.39_00505	1125971.ASJB01000074_gene43	5.7e-132	477.6	Pseudonocardiales													Bacteria	2IAMG@201174,4E68T@85010,COG0427@1,COG0427@2	NA|NA|NA	C	Acetyl-CoA hydrolase/transferase C-terminal domain
MAG.T22.39_00506	443906.CMM_1599	1e-112	413.3	Microbacteriaceae	fcl		1.1.1.271	ko:K02377,ko:K16554	ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111		R05692	RC01014	ko00000,ko00001,ko01000,ko02000	8.A.3.1			Bacteria	2GP0W@201174,4FMFH@85023,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
MAG.T22.39_00509	1401064.HMPREF2129_07815	1.2e-142	513.1	Corynebacteriaceae				ko:K07133					ko00000				Bacteria	22JWC@1653,2GK4E@201174,COG1373@1,COG1373@2	NA|NA|NA	S	Domain of unknown function (DUF4143)
MAG.T22.39_00510	1267535.KB906767_gene5328	3.3e-50	204.9	Acidobacteria	gmhA		5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	3Y7D7@57723,COG0279@1,COG0279@2	NA|NA|NA	G	SIS domain
MAG.T22.39_00511	1340493.JNIF01000003_gene4379	5.3e-44	184.9	Bacteria	glk		2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	COG1940@1,COG1940@2	NA|NA|NA	GK	ROK family
MAG.T22.39_00513	656024.FsymDg_2935	1.3e-13	82.8	Bacteria	vapC												Bacteria	COG1848@1,COG1848@2	NA|NA|NA	G	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_00515	529884.Rhola_00013260	3.5e-27	128.6	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HT82@201174,4FSEQ@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_00518	1463885.KL578443_gene1577	9.8e-13	79.7	Actinobacteria													Bacteria	2D7MD@1,2IRM1@201174,32TP9@2	NA|NA|NA	S	DoxX-like family
MAG.T22.39_00519	1122939.ATUD01000001_gene793	4.8e-27	127.1	Rubrobacteria													Bacteria	2IGMY@201174,4CT46@84995,COG1487@1,COG1487@2	NA|NA|NA	S	PIN domain
MAG.T22.39_00522	529884.Rhola_00013270	2.5e-13	84.0	Microbacteriaceae													Bacteria	2BFXJ@1,2HTFG@201174,329T7@2,4FT9Y@85023	NA|NA|NA		
MAG.T22.39_00523	529884.Rhola_00013260	3.4e-27	128.6	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HT82@201174,4FSEQ@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_00524	580332.Slit_1469	1e-11	79.7	Betaproteobacteria													Bacteria	1QU2X@1224,2VHDJ@28216,COG4625@1,COG4625@2	NA|NA|NA	MU	TIGRFAM outer membrane autotransporter barrel domain protein
MAG.T22.39_00525	1380393.JHVP01000014_gene4774	1.4e-154	552.7	Frankiales	menJ	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	1.3.99.38	ko:K21401					ko00000,ko01000				Bacteria	2GKGH@201174,4ERPF@85013,COG0644@1,COG0644@2	NA|NA|NA	C	geranylgeranyl reductase
MAG.T22.39_00526	105425.BBPL01000029_gene3951	2.4e-25	124.0	Streptacidiphilus													Bacteria	2IAMD@201174,2NG9U@228398,COG4932@1,COG4932@2	NA|NA|NA	M	domain protein
MAG.T22.39_00527	529884.Rhola_00002620	1.1e-60	240.4	Microbacteriaceae													Bacteria	2GK49@201174,4FKTG@85023,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_00528	590998.Celf_3546	3.2e-34	151.4	Actinobacteria													Bacteria	2AWFS@1,2IMS0@201174,31NC1@2	NA|NA|NA		
MAG.T22.39_00530	710111.FraQA3DRAFT_5149	1.3e-166	593.2	Frankiales	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K06877					ko00000				Bacteria	2GJJ6@201174,4ERHU@85013,COG1205@1,COG1205@2	NA|NA|NA	L	DEAD DEAH box helicase
MAG.T22.39_00531	1236902.ANAS01000030_gene2999	3e-07	61.6	Streptosporangiales													Bacteria	2DRBM@1,2GXTD@201174,33B4F@2,4EKWJ@85012	NA|NA|NA	S	TIGRFAM helicase secretion neighborhood TadE-like protein
MAG.T22.39_00534	561175.KB894093_gene3716	4.2e-21	108.6	Streptosporangiales	gspF			ko:K12510,ko:K12511					ko00000,ko02044				Bacteria	2IQE9@201174,4EJVY@85012,COG2064@1,COG2064@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein F
MAG.T22.39_00535	67373.JOBF01000006_gene2622	7.4e-23	114.4	Actinobacteria				ko:K12510					ko00000,ko02044				Bacteria	2I8NR@201174,COG4965@1,COG4965@2	NA|NA|NA	U	Type ii secretion system
MAG.T22.39_00536	1380346.JNIH01000026_gene5868	1e-106	393.7	Actinobacteria	cpaF			ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GKKJ@201174,COG4962@1,COG4962@2	NA|NA|NA	U	Type ii secretion system protein e
MAG.T22.39_00537	28444.JODQ01000014_gene6785	4.8e-47	195.3	Streptosporangiales	cpaE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464		ko:K04562					ko00000,ko02035				Bacteria	2GIVN@201174,4EHZE@85012,COG0455@1,COG0455@2	NA|NA|NA	D	bacterial-type flagellum organization
MAG.T22.39_00538	1380356.JNIK01000011_gene1833	2.4e-80	305.4	Frankiales	ssgB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	2GJVX@201174,4ERXM@85013,COG0560@1,COG0560@2	NA|NA|NA	E	haloacid dehalogenase-like hydrolase
MAG.T22.39_00539	561175.KB894093_gene3721	2.3e-38	166.0	Streptosporangiales													Bacteria	2GIT8@201174,4EG60@85012,COG3177@1,COG3177@2	NA|NA|NA	S	Filamentation induced by cAMP protein fic
MAG.T22.39_00540	103733.JNYO01000035_gene3055	1.8e-297	1028.1	Pseudonocardiales	acsA		6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GJCG@201174,4DXD0@85010,COG0365@1,COG0365@2	NA|NA|NA	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAG.T22.39_00541	1123320.KB889692_gene169	5.2e-112	411.4	Actinobacteria	nhaA			ko:K03313					ko00000,ko02000	2.A.33.1			Bacteria	2GKIK@201174,COG3004@1,COG3004@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MAG.T22.39_00543	1048339.KB913029_gene1221	5.1e-65	254.6	Frankiales													Bacteria	2I2IM@201174,4EXEF@85013,COG2267@1,COG2267@2	NA|NA|NA	I	Serine aminopeptidase, S33
MAG.T22.39_00544	1205910.B005_1844	9.7e-60	237.7	Streptosporangiales	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944		ko:K03558					ko00000				Bacteria	2GJ92@201174,4EHJ9@85012,COG0265@1,COG0265@2,COG1286@1,COG1286@2	NA|NA|NA	O	Colicin V production protein
MAG.T22.39_00545	1120950.KB892762_gene5484	3.3e-49	201.8	Propionibacteriales													Bacteria	2GKG9@201174,4DQJF@85009,COG0494@1,COG0494@2	NA|NA|NA	L	NUDIX domain
MAG.T22.39_00546	1033730.CAHG01000008_gene3007	1.6e-27	129.8	Propionibacteriales				ko:K02199					ko00000,ko03110				Bacteria	2IMNX@201174,4DRHV@85009,COG0526@1,COG0526@2	NA|NA|NA	CO	Redoxin
MAG.T22.39_00547	1306174.JODP01000001_gene5350	4.7e-80	304.3	Actinobacteria	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141		ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	2GMPN@201174,COG0664@1,COG0664@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_00548	479433.Caci_8910	5.3e-62	244.6	Actinobacteria	MA20_07390		3.1.2.6	ko:K01069,ko:K07455	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000,ko03400				Bacteria	2GKP9@201174,COG0491@1,COG0491@2	NA|NA|NA	L	Zn-dependent hydrolases, including glyoxylases
MAG.T22.39_00549	1032480.MLP_50070	2.9e-18	99.0	Actinobacteria													Bacteria	2I7CU@201174,COG1051@1,COG1051@2	NA|NA|NA	F	NUDIX domain
MAG.T22.39_00550	1033730.CAHG01000008_gene3002	1.9e-35	155.6	Propionibacteriales													Bacteria	2IHNE@201174,4DQIS@85009,COG0251@1,COG0251@2	NA|NA|NA	J	YjgF/chorismate_mutase-like, putative endoribonuclease
MAG.T22.39_00551	561175.KB894093_gene3740	9.1e-102	377.1	Streptosporangiales	arsA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.3.16	ko:K01551					ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1			Bacteria	2GJ0J@201174,4EGQR@85012,COG0003@1,COG0003@2	NA|NA|NA	P	Anion-transporting ATPase
MAG.T22.39_00552	313589.JNB_10099	1.6e-131	476.1	Intrasporangiaceae	arsA		3.6.3.16	ko:K01551					ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1			Bacteria	2GJYN@201174,4FFB0@85021,COG0003@1,COG0003@2	NA|NA|NA	P	Anion-transporting ATPase
MAG.T22.39_00553	996637.SGM_4217	3.9e-37	160.6	Actinobacteria	whiB4	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0030312,GO:0043254,GO:0044087,GO:0044464,GO:0047134,GO:0048037,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071944,GO:0090034,GO:0097159,GO:1901363		ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQEP@201174,32TCV@2	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T22.39_00555	1211815.CBYP010000030_gene1277	2.9e-25	120.9	Frankiales				ko:K03892					ko00000,ko03000				Bacteria	2IKUI@201174,4EW7P@85013,COG0640@1,COG0640@2	NA|NA|NA	K	transcriptional regulator, ArsR family
MAG.T22.39_00556	1211815.CBYP010000030_gene1278	6.9e-77	293.9	Frankiales			2.5.1.105	ko:K04088,ko:K06897	ko00790,map00790	M00742	R10339	RC00121	ko00000,ko00001,ko00002,ko01000				Bacteria	2GQJJ@201174,4ERTV@85013,COG0053@1,COG0053@2	NA|NA|NA	P	Cation efflux family
MAG.T22.39_00557	1032480.MLP_52440	2.4e-95	355.5	Propionibacteriales	czcD			ko:K16264					ko00000,ko02000	2.A.4.1			Bacteria	2GMRZ@201174,4DNBF@85009,COG1230@1,COG1230@2	NA|NA|NA	P	Cation efflux family
MAG.T22.39_00558	1184609.KILIM_044_00320	4.6e-27	127.1	Actinobacteria													Bacteria	2IR8D@201174,COG3339@1,COG3339@2	NA|NA|NA	O	Conserved Protein
MAG.T22.39_00560	469371.Tbis_1417	3.5e-11	74.3	Pseudonocardiales	MA20_25230			ko:K09131					ko00000				Bacteria	2GQSC@201174,4E6KR@85010,COG1872@1,COG1872@2	NA|NA|NA	EGP	Belongs to the UPF0235 family
MAG.T22.39_00561	1394178.AWOO02000030_gene4736	9.7e-09	67.8	Streptosporangiales													Bacteria	2IC88@201174,4EH6N@85012,COG0615@1,COG0615@2	NA|NA|NA	IM	Sulfotransferase domain
MAG.T22.39_00563	1394178.AWOO02000048_gene6347	3.1e-16	91.7	Streptosporangiales	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141		ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	2IR95@201174,4EK0D@85012,COG0776@1,COG0776@2	NA|NA|NA	L	regulation of translation
MAG.T22.39_00564	1504319.GM45_0350	1.8e-203	715.7	unclassified Actinobacteria (class)	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944		ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	2GJFX@201174,3UWAA@52018,COG0358@1,COG0358@2	NA|NA|NA	K	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MAG.T22.39_00565	1254432.SCE1572_50845	4.9e-104	384.8	Proteobacteria													Bacteria	1MX5B@1224,COG0520@1,COG0520@2	NA|NA|NA	E	Aminotransferase class V
MAG.T22.39_00566	1137268.AZXF01000012_gene3596	1.8e-117	429.5	Streptosporangiales	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230		R01856	RC00017	ko00000,ko00001,ko01000				Bacteria	2GJ8F@201174,4EI7F@85012,COG0232@1,COG0232@2	NA|NA|NA	F	Phosphohydrolase-associated domain
MAG.T22.39_00567	1137268.AZXF01000012_gene3595	3.2e-15	89.0	Streptosporangiales													Bacteria	2I2NF@201174,4ENS4@85012,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
MAG.T22.39_00568	479431.Namu_4080	0.0	1187.2	Frankiales	ppdK		2.7.3.13,2.7.9.1	ko:K01006,ko:K22424	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK73@201174,4ERQZ@85013,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	G	pyruvate phosphate dikinase, PEP
MAG.T22.39_00569	1504319.GM45_0335	1.9e-137	495.7	unclassified Actinobacteria (class)	dus												Bacteria	2GJ8I@201174,3UWD7@52018,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MAG.T22.39_00570	525904.Tter_1557	5.6e-135	488.0	Bacteria													Bacteria	COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T22.39_00571	1504319.GM45_0330	9.9e-226	789.3	unclassified Actinobacteria (class)	glyQS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iSB619.SA_RS07880	Bacteria	2GIT3@201174,3UW9K@52018,COG0423@1,COG0423@2	NA|NA|NA	J	Catalyzes the attachment of glycine to tRNA(Gly)
MAG.T22.39_00572	59931.WH7805_00330	8.1e-53	214.5	Synechococcus													Bacteria	1GNCU@1117,1H0RU@1129,COG1289@1,COG1289@2	NA|NA|NA	S	transmembrane transporter activity
MAG.T22.39_00573	1380393.JHVP01000007_gene4331	6.2e-64	251.1	Frankiales	cyeA												Bacteria	2GK49@201174,4ESEQ@85013,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_00575	479433.Caci_7256	7e-57	227.3	Actinobacteria	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.26.4,3.1.3.73,3.1.3.85	ko:K02226,ko:K22306,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032				Bacteria	2GJYU@201174,COG0406@1,COG0406@2	NA|NA|NA	G	Belongs to the phosphoglycerate mutase family
MAG.T22.39_00576	1298863.AUEP01000005_gene2613	1.3e-37	162.5	Propionibacteriales	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2IKZ3@201174,4DR96@85009,COG0799@1,COG0799@2	NA|NA|NA	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MAG.T22.39_00577	100226.SCO2579	2.2e-68	265.4	Actinobacteria	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2GMFZ@201174,COG1057@1,COG1057@2	NA|NA|NA	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MAG.T22.39_00579	269800.Tfu_2175	1.1e-154	553.1	Streptosporangiales	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130	Bacteria	2GISA@201174,4EGZ1@85012,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAG.T22.39_00580	1133850.SHJG_4081	8.5e-24	116.7	Actinobacteria													Bacteria	2E4W3@1,2II8G@201174,32ZQA@2	NA|NA|NA		
MAG.T22.39_00581	1122138.AQUZ01000017_gene6539	6.6e-130	470.7	Propionibacteriales	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM8U@201174,4DNUG@85009,COG0263@1,COG0263@2	NA|NA|NA	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MAG.T22.39_00582	1134445.AJJM01000193_gene3804	6e-183	647.1	Actinobacteria	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904		ko:K03979					ko00000,ko01000,ko03009				Bacteria	2GISB@201174,COG0536@1,COG0536@2	NA|NA|NA	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MAG.T22.39_00583	1454010.JEOE01000007_gene2036	1.5e-34	151.8	Cellulomonadaceae	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904		ko:K02899	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQDI@201174,4F2P7@85016,COG0211@1,COG0211@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL27 family
MAG.T22.39_00584	1048339.KB913029_gene4852	5.3e-34	150.2	Frankiales	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02888	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2	NA|NA|NA	J	This protein binds to 23S rRNA in the presence of protein L20
MAG.T22.39_00585	73044.JNXP01000016_gene476	2.2e-208	732.3	Actinobacteria	rne	GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394			ko00000,ko00001,ko00002,ko01000,ko03009,ko03019				Bacteria	2GMM5@201174,COG1530@1,COG1530@2	NA|NA|NA	J	ribonuclease Rne Rng family
MAG.T22.39_00586	106370.Francci3_4352	9.6e-24	115.5	Frankiales	dnaK			ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	2GJTY@201174,4ERTY@85013,COG0443@1,COG0443@2	NA|NA|NA	O	Heat shock 70 kDa protein
MAG.T22.39_00587	1120960.ATXG01000004_gene1805	6.8e-87	327.4	Microbacteriaceae	hutG		3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJA6@201174,4FKS9@85023,COG0010@1,COG0010@2	NA|NA|NA	E	Arginase family
MAG.T22.39_00588	1123020.AUIE01000053_gene1768	8.5e-95	353.6	Pseudomonas aeruginosa group													Bacteria	1PF68@1224,1RYF8@1236,1YIHU@136841,COG5285@1,COG5285@2	NA|NA|NA	Q	Phytanoyl-CoA dioxygenase (PhyH)
MAG.T22.39_00589	882086.SacxiDRAFT_0468	4.2e-56	224.9	Pseudonocardiales													Bacteria	2GM23@201174,4E01E@85010,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_00590	1380347.JNII01000005_gene3245	2.7e-270	937.6	Frankiales	hutU		4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000				Bacteria	2GP10@201174,4ESAM@85013,COG2987@1,COG2987@2	NA|NA|NA	E	Urocanase C-terminal domain
MAG.T22.39_00591	1449346.JQMO01000003_gene5307	8.9e-143	513.5	Kitasatospora	hutI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJH4@201174,2M0TG@2063,COG1228@1,COG1228@2	NA|NA|NA	Q	Amidohydrolase family
MAG.T22.39_00592	529884.Rhola_00000280	1.3e-202	712.6	Microbacteriaceae	hutH		4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZW@201174,4FMRY@85023,COG2986@1,COG2986@2	NA|NA|NA	E	Aromatic amino acid lyase
MAG.T22.39_00593	931627.MycrhDRAFT_2921	7.5e-236	823.5	Mycobacteriaceae	fimV_2			ko:K19719	ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165				ko00000,ko00001,ko00536				Bacteria	232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2	NA|NA|NA	C	Fe-S oxidoreductase
MAG.T22.39_00594	1463903.JOIZ01000021_gene7090	1.1e-13	83.2	Actinobacteria													Bacteria	2IFGG@201174,COG4702@1,COG4702@2	NA|NA|NA	S	Belongs to the UPF0303 family
MAG.T22.39_00595	1120941.AUBL01000025_gene88	3.1e-10	70.9	Actinobacteria				ko:K07746					ko00000,ko02048				Bacteria	2I6Q5@201174,COG3609@1,COG3609@2	NA|NA|NA	K	addiction module antidote protein, CC2985 family
MAG.T22.39_00596	1123024.AUII01000045_gene570	3e-26	124.4	Actinobacteria	mazF3	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07171					ko00000,ko01000,ko02048				Bacteria	2ISBP@201174,COG2337@1,COG2337@2	NA|NA|NA	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system
MAG.T22.39_00597	1121353.H924_06735	3.7e-37	161.4	Corynebacteriaceae	gpt		2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110		R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	22K04@1653,2GN86@201174,COG2236@1,COG2236@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T22.39_00598	479432.Sros_0890	6.8e-96	356.7	Streptosporangiales	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0033973,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000			iPC815.YPO1525	Bacteria	2GKQQ@201174,4EFVK@85012,COG0717@1,COG0717@2	NA|NA|NA	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)
MAG.T22.39_00600	1123023.JIAI01000007_gene1998	2.6e-27	128.3	Actinobacteria		GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007		ko:K19686					ko00000,ko01000,ko02048				Bacteria	2IS39@201174,COG3742@1,COG3742@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_00601	1313172.YM304_01740	1.3e-41	176.8	Acidimicrobiia													Bacteria	2HGPN@201174,4CNRY@84992,COG2207@1,COG2207@2	NA|NA|NA	K	helix_turn_helix, arabinose operon control protein
MAG.T22.39_00602	1313172.YM304_01730	1.3e-276	959.5	Acidimicrobiia	putA		1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130		R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000				Bacteria	2GM5R@201174,4CNNB@84992,COG0506@1,COG0506@2,COG1012@1,COG1012@2	NA|NA|NA	CE	Proline dehydrogenase
MAG.T22.39_00603	998674.ATTE01000001_gene3953	2e-28	132.1	Gammaproteobacteria		GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944		ko:K07064					ko00000				Bacteria	1RK9K@1224,1SBYF@1236,COG1848@1,COG1848@2	NA|NA|NA	S	PIN domain
MAG.T22.39_00605	58344.JOEL01000001_gene307	2.9e-22	112.5	Actinobacteria	ywiC												Bacteria	28NT3@1,2IIC3@201174,2ZBRV@2	NA|NA|NA	S	YwiC-like protein
MAG.T22.39_00606	1206741.BAFX01000102_gene1434	4.1e-44	184.1	Nocardiaceae				ko:K09966					ko00000				Bacteria	2IHNI@201174,4G0HJ@85025,COG3651@1,COG3651@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2237)
MAG.T22.39_00609	1229781.C272_06179	3e-127	462.6	Actinobacteria													Bacteria	2IC33@201174,COG0323@1,COG0323@2	NA|NA|NA	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MAG.T22.39_00610	1203568.HMPREF1484_00751	0.0	1552.0	Dermabacteraceae	hsdR		3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	2HI69@201174,4FDXM@85020,COG0610@1,COG0610@2	NA|NA|NA	V	Subunit R is required for both nuclease and ATPase activities, but not for modification
MAG.T22.39_00611	1452718.JBOY01000027_gene82	9.5e-162	577.0	Gammaproteobacteria	yfjM												Bacteria	1R5X1@1224,1RYM1@1236,COG1479@1,COG1479@2,COG3472@1,COG3472@2	NA|NA|NA	S	Protein of unknown function DUF262
MAG.T22.39_00612	266265.Bxe_A0223	2.4e-74	286.2	Burkholderiaceae			3.1.21.3	ko:K01154					ko00000,ko01000,ko02048				Bacteria	1KAKR@119060,1MXSQ@1224,2VT2C@28216,COG0732@1,COG0732@2	NA|NA|NA	V	Type I restriction modification DNA specificity domain
MAG.T22.39_00613	471856.Jden_2248	4.4e-246	857.1	Actinobacteria	hsdM		2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	2GKAQ@201174,COG0286@1,COG0286@2	NA|NA|NA	V	Type I restriction-modification system methyltransferase subunit
MAG.T22.39_00616	419947.MRA_1057	3.7e-42	179.1	Actinobacteria													Bacteria	2H1DQ@201174,COG4861@1,COG4861@2	NA|NA|NA	S	Protein conserved in bacteria
MAG.T22.39_00617	1348338.ADILRU_0107	2.4e-25	122.9	Microbacteriaceae													Bacteria	28HCU@1,2GPHN@201174,2Z7PM@2,4FSAB@85023	NA|NA|NA		
MAG.T22.39_00619	1068978.AMETH_1716	1.5e-63	250.4	Actinobacteria													Bacteria	2GISN@201174,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T22.39_00620	1123023.JIAI01000021_gene2356	4e-132	478.0	Bacteria	mocD												Bacteria	COG3239@1,COG3239@2	NA|NA|NA	I	unsaturated fatty acid biosynthetic process
MAG.T22.39_00621	2074.JNYD01000003_gene3537	3e-32	144.4	Actinobacteria				ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002				Bacteria	2GT7I@201174,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
MAG.T22.39_00622	526226.Gbro_2734	1.7e-75	290.4	Gordoniaceae													Bacteria	2GKB5@201174,4GCMS@85026,COG4425@1,COG4425@2	NA|NA|NA	S	Alpha/beta-hydrolase family N-terminus
MAG.T22.39_00624	367299.JOEE01000004_gene1045	4.6e-194	684.1	Intrasporangiaceae			5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJSH@201174,4FFWW@85021,COG0001@1,COG0001@2	NA|NA|NA	H	Aminotransferase class-III
MAG.T22.39_00625	1120958.AULD01000005_gene2276	6.6e-33	147.9	Microbacteriaceae				ko:K07090					ko00000				Bacteria	2I5VT@201174,4FMK5@85023,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T22.39_00626	243160.BMA0791	1.1e-29	136.7	Burkholderiaceae			5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	1K8ZG@119060,1RH8P@1224,2VUH5@28216,COG0406@1,COG0406@2	NA|NA|NA	G	alpha-ribazole phosphatase activity
MAG.T22.39_00628	1907.SGLAU_20825	6.1e-76	290.8	Actinobacteria	dprE2		1.1.1.333	ko:K16652					ko00000,ko01000				Bacteria	2GNPI@201174,COG0300@1,COG0300@2	NA|NA|NA	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)
MAG.T22.39_00629	232348.ADXL01000091_gene450	3.6e-143	515.0	Cyanobacteria			1.1.98.3	ko:K16653					ko00000,ko01000				Bacteria	1G3Q2@1117,COG0277@1,COG0277@2	NA|NA|NA	C	FAD binding domain
MAG.T22.39_00630	1211815.CBYP010000044_gene393	1.8e-82	312.8	Frankiales	ubiA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046872,GO:0052636,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.2.45	ko:K14136			R10095	RC00005	ko00000,ko01000,ko01006				Bacteria	2GJ6P@201174,4EV3I@85013,COG0382@1,COG0382@2	NA|NA|NA	H	UbiA prenyltransferase family
MAG.T22.39_00632	1394178.AWOO02000004_gene2330	1e-241	842.8	Streptosporangiales	acd												Bacteria	2GJIB@201174,4EFZX@85012,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-CoA dehydrogenase N terminal
MAG.T22.39_00633	1463853.JOHW01000033_gene6725	4.3e-89	335.1	Actinobacteria				ko:K03455					ko00000	2.A.37			Bacteria	2GJ69@201174,COG0475@1,COG0475@2	NA|NA|NA	P	Pfam Sodium hydrogen exchanger
MAG.T22.39_00634	1713.JOFV01000003_gene1614	5.1e-21	107.8	Cellulomonadaceae	copC			ko:K07156,ko:K14166					ko00000,ko02000	9.B.62.2			Bacteria	2HYZZ@201174,4F1HZ@85016,COG2372@1,COG2372@2	NA|NA|NA	S	CopC domain
MAG.T22.39_00635	269800.Tfu_0963	5.7e-129	468.4	Streptosporangiales	copD			ko:K02351,ko:K07245					ko00000,ko02000	9.B.62.1			Bacteria	2GKIR@201174,4EGUX@85012,COG1276@1,COG1276@2,COG3336@1,COG3336@2	NA|NA|NA	P	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
MAG.T22.39_00636	1169161.KB897716_gene5980	1.2e-52	214.5	Actinobacteria													Bacteria	2IE5J@201174,COG2247@1,COG2247@2	NA|NA|NA	M	cell wall binding repeat
MAG.T22.39_00637	1229203.KI301992_gene1845	2.6e-34	151.0	unclassified Actinobacteria (class)	whiB2			ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQ4Q@201174,32RUK@2,3UWSD@52018	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T22.39_00638	67257.JODR01000011_gene5590	3.1e-120	438.3	Actinobacteria	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZ2@201174,COG0391@1,COG0391@2	NA|NA|NA	S	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP
MAG.T22.39_00639	1123322.KB904717_gene5085	9e-115	420.6	Actinobacteria	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJ8@201174,COG0778@1,COG0778@2,COG1478@1,COG1478@2	NA|NA|NA	C	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MAG.T22.39_00640	68570.DC74_3468	1.7e-108	399.4	Actinobacteria	manC		2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKTE@201174,COG1208@1,COG1208@2	NA|NA|NA	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits
MAG.T22.39_00641	675635.Psed_5216	9.5e-18	97.4	Pseudonocardiales													Bacteria	2GIX4@201174,4EF7W@85010,COG0318@1,COG0318@2	NA|NA|NA	IQ	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MAG.T22.39_00642	367299.JOEE01000003_gene2998	1.4e-69	271.9	Intrasporangiaceae													Bacteria	2GNDB@201174,4FJZJ@85021,COG2385@1,COG2385@2,COG5479@1,COG5479@2	NA|NA|NA	DM	Stage II sporulation protein
MAG.T22.39_00646	1449976.KALB_1985	1.2e-20	106.3	Pseudonocardiales				ko:K05554,ko:K14670	ko01056,ko01130,map01056,map01130	M00778	R09265	RC02546	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008				Bacteria	2IIBS@201174,4E3YX@85010,COG2867@1,COG2867@2	NA|NA|NA	I	negative regulation of translational initiation
MAG.T22.39_00647	1120936.KB907210_gene5845	6.9e-83	313.9	Streptosporangiales													Bacteria	2GMTQ@201174,4EHDC@85012,COG2129@1,COG2129@2	NA|NA|NA	S	Calcineurin-like phosphoesterase superfamily domain
MAG.T22.39_00648	2045.KR76_11080	1.6e-39	169.1	Propionibacteriales													Bacteria	2IFH4@201174,4DRBM@85009,COG2867@1,COG2867@2	NA|NA|NA	I	Polyketide cyclase / dehydrase and lipid transport
MAG.T22.39_00651	37919.EP51_20030	2.2e-86	325.9	Nocardiaceae	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJCQ@201174,4FZVS@85025,COG1940@1,COG1940@2	NA|NA|NA	G	ROK family
MAG.T22.39_00652	1306174.JODP01000009_gene6570	2.2e-08	65.5	Bacteria													Bacteria	2EN8E@1,33FW7@2	NA|NA|NA		
MAG.T22.39_00653	1120948.KB903248_gene4304	4e-72	278.1	Pseudonocardiales	yvaK		3.1.1.1	ko:K03928					ko00000,ko01000				Bacteria	2GM1Y@201174,4DZX1@85010,COG1647@1,COG1647@2	NA|NA|NA	S	PFAM alpha beta hydrolase fold
MAG.T22.39_00654	298653.Franean1_1829	4.6e-92	344.4	Frankiales	plsC		2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GJ6V@201174,4ERMB@85013,COG0204@1,COG0204@2	NA|NA|NA	I	PFAM Phospholipid glycerol acyltransferase
MAG.T22.39_00655	1298863.AUEP01000002_gene1490	2.4e-169	602.1	Propionibacteriales	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626		R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147				Bacteria	2GM13@201174,4DNYQ@85009,COG0554@1,COG0554@2	NA|NA|NA	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAG.T22.39_00656	1123320.KB889675_gene3895	6.1e-156	557.0	Actinobacteria	pfkA		2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019				Bacteria	2GK6W@201174,COG0205@1,COG0205@2	NA|NA|NA	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MAG.T22.39_00657	67373.JOBF01000015_gene5170	2.9e-174	618.2	Actinobacteria	aroH		2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJBX@201174,COG3200@1,COG3200@2	NA|NA|NA	E	Belongs to the class-II DAHP synthase family
MAG.T22.39_00658	1123023.JIAI01000007_gene1804	1.5e-152	545.8	Pseudonocardiales													Bacteria	2GKHN@201174,4E24Y@85010,COG2141@1,COG2141@2	NA|NA|NA	C	Luciferase-like monooxygenase
MAG.T22.39_00659	930171.Asphe3_10460	7.4e-51	207.2	Micrococcaceae													Bacteria	1W9MJ@1268,2GK9V@201174,COG1853@1,COG1853@2	NA|NA|NA	S	Flavin reductase like domain
MAG.T22.39_00660	1122182.KB903818_gene1956	6e-55	221.1	Actinobacteria													Bacteria	2GK20@201174,COG1028@1,COG1028@2	NA|NA|NA	IQ	Short-chain dehydrogenase reductase sdr
MAG.T22.39_00661	247156.NFA_12450	5.3e-296	1023.5	Nocardiaceae	abmA	GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700	1.14.13.40,1.6.99.1	ko:K00354,ko:K09461	ko00627,ko01120,map00627,map01120		R00282,R03998,R03999	RC00001,RC00244	ko00000,ko00001,ko01000				Bacteria	2GK8E@201174,4G9MH@85025,COG0654@1,COG0654@2,COG1902@1,COG1902@2	NA|NA|NA	CH	NADH:flavin oxidoreductase / NADH oxidase family
MAG.T22.39_00662	1463917.JODC01000029_gene990	2.6e-98	365.2	Actinobacteria	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0016787,GO:0016810,GO:0016812,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNFV@201174,COG1878@1,COG1878@2	NA|NA|NA	S	PFAM cyclase family protein
MAG.T22.39_00664	1444306.JFZC01000034_gene2693	7.4e-21	107.5	Sporolactobacillaceae	oatA												Bacteria	1TPTG@1239,26PW3@186821,4HB7R@91061,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase family
MAG.T22.39_00665	981369.JQMJ01000004_gene6405	4.5e-23	113.6	Streptacidiphilus				ko:K21600					ko00000,ko03000				Bacteria	2IQ7U@201174,2NJCG@228398,COG1937@1,COG1937@2	NA|NA|NA	S	Metal-sensitive transcriptional repressor
MAG.T22.39_00666	196162.Noca_3748	9.1e-38	162.9	Actinobacteria			3.1.1.24,4.1.1.44	ko:K01607,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000				Bacteria	2IRPW@201174,COG0599@1,COG0599@2	NA|NA|NA	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAG.T22.39_00667	1121946.AUAX01000019_gene7777	1.6e-50	206.5	Actinobacteria													Bacteria	2ISWE@201174,COG3340@1,COG3340@2	NA|NA|NA	E	Peptidase family S51
MAG.T22.39_00668	253839.SSNG_03720	8e-46	190.7	Actinobacteria	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02493,ko:K02527,ko:K03439	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763,R10806	RC00003,RC00009,RC00077,RC00247,RC03279	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016		GT30		Bacteria	2GJ8R@201174,COG0220@1,COG0220@2	NA|NA|NA	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MAG.T22.39_00669	1122138.AQUZ01000032_gene7149	5e-110	404.4	Propionibacteriales													Bacteria	2GKW0@201174,4DTQY@85009,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, NAD-binding Rossmann fold
MAG.T22.39_00670	1121020.JIAG01000002_gene773	1.5e-32	146.4	Micrococcaceae													Bacteria	1W8KT@1268,2IKUE@201174,COG3544@1,COG3544@2	NA|NA|NA	S	Domain of unknown function (DUF305)
MAG.T22.39_00671	465541.ATCJ01000005_gene1684	2.8e-70	272.7	Actinobacteria	nhaP			ko:K03316					ko00000	2.A.36			Bacteria	2I9RZ@201174,COG0025@1,COG0025@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T22.39_00672	1209072.ALBT01000082_gene259	1.3e-13	83.6	Gammaproteobacteria			3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1P4DD@1224,1SUVB@1236,COG0265@1,COG0265@2	NA|NA|NA	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAG.T22.39_00673	1416752.AYME01000003_gene3090	4.9e-66	258.5	Actinobacteria													Bacteria	2I55Q@201174,COG4422@1,COG4422@2	NA|NA|NA	S	Protein of unknown function (DUF5131)
MAG.T22.39_00674	1157943.KB892705_gene2069	6.5e-115	420.2	Mycobacteriaceae													Bacteria	2357K@1762,2GJHQ@201174,COG4422@1,COG4422@2	NA|NA|NA	S	Protein of unknown function (DUF5131)
MAG.T22.39_00679	1177594.MIC448_160002	6.8e-140	505.0	Actinobacteria			3.1.21.5	ko:K01156					ko00000,ko01000,ko02048				Bacteria	2I9VK@201174,COG1061@1,COG1061@2	NA|NA|NA	KL	Type III restriction enzyme res subunit
MAG.T22.39_00680	672.VV93_v1c02530	5.5e-179	634.4	Vibrionales			2.1.1.72	ko:K07316					ko00000,ko01000,ko02048				Bacteria	1MX9M@1224,1RNHM@1236,1XX90@135623,COG2189@1,COG2189@2	NA|NA|NA	L	DNA methylase
MAG.T22.39_00681	1027273.GZ77_04775	7e-30	136.7	Oceanospirillales			2.1.1.72	ko:K07316					ko00000,ko01000,ko02048				Bacteria	1MX9M@1224,1RNHM@1236,1XKQB@135619,COG2189@1,COG2189@2	NA|NA|NA	L	DNA methylase
MAG.T22.39_00682	314278.NB231_05916	8.8e-29	133.3	Chromatiales	hicB			ko:K18843					ko00000,ko02048				Bacteria	1RI8S@1224,1SB9V@1236,1WYVP@135613,COG1598@1,COG1598@2	NA|NA|NA	S	nucleic acid-templated transcription
MAG.T22.39_00686	1504319.GM45_4165	1.8e-70	272.7	unclassified Actinobacteria (class)	nuoJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GKRS@201174,3UWWC@52018,COG0839@1,COG0839@2	NA|NA|NA	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6
MAG.T22.39_00687	1504319.GM45_4160	1.6e-68	265.8	unclassified Actinobacteria (class)	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00337,ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iNJ661.Rv3153	Bacteria	2GJNU@201174,3UWSS@52018,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_00688	1504319.GM45_4155	1.3e-150	539.7	unclassified Actinobacteria (class)	nuoH		1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GIVY@201174,3UW85@52018,COG1005@1,COG1005@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MAG.T22.39_00689	561175.KB894093_gene4354	1.8e-254	885.6	Streptosporangiales	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GJGX@201174,4EGC2@85012,COG1034@1,COG1034@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
MAG.T22.39_00690	1504319.GM45_4145	2.7e-180	638.3	unclassified Actinobacteria (class)	nuoF		1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GMMC@201174,3UWD5@52018,COG1894@1,COG1894@2	NA|NA|NA	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
MAG.T22.39_00691	1504319.GM45_4140	1.4e-65	256.1	unclassified Actinobacteria (class)	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3,1.6.99.3	ko:K00334,ko:K00335,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6			Bacteria	2GKG0@201174,3UWSV@52018,COG1905@1,COG1905@2	NA|NA|NA	C	Thioredoxin-like [2Fe-2S] ferredoxin
MAG.T22.39_00692	996637.SGM_1286	9e-195	686.4	Actinobacteria	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GKEZ@201174,COG0649@1,COG0649@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_00693	1449069.JMLO01000014_gene4407	1.5e-89	335.9	Nocardiaceae	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GIRH@201174,4FUNS@85025,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_00694	397278.JOJN01000002_gene332	1.2e-86	325.9	Propionibacteriales	nuoB		1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GJXR@201174,4DNIV@85009,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_00695	1003195.SCAT_3484	3.1e-46	191.0	Actinobacteria	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2IKWT@201174,COG0838@1,COG0838@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_00696	1160718.SU9_16322	2.1e-91	342.0	Actinobacteria	ubiE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000			iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Bacteria	2GKFZ@201174,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MAG.T22.39_00697	1380370.JIBA01000019_gene1027	2.4e-117	429.1	Intrasporangiaceae	menF		5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKE8@201174,4FEWQ@85021,COG1169@1,COG1169@2	NA|NA|NA	HQ	Isochorismate synthase
MAG.T22.39_00698	1048339.KB913029_gene2364	1.2e-111	410.6	Frankiales	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS05085	Bacteria	2GMEB@201174,4ES4N@85013,COG1165@1,COG1165@2	NA|NA|NA	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MAG.T22.39_00699	561175.KB894096_gene527	6.6e-65	254.6	Streptosporangiales	menC		4.2.1.113,5.1.1.20,5.1.1.3	ko:K01776,ko:K02549,ko:K19802	ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110	M00116	R00260,R04031,R10938	RC00302,RC01053,RC03309	ko00000,ko00001,ko00002,ko01000,ko01011			iSB619.SA_RS09080	Bacteria	2GJJR@201174,4EH71@85012,COG4948@1,COG4948@2	NA|NA|NA	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MAG.T22.39_00700	65497.JODV01000007_gene534	2.8e-131	474.9	Pseudonocardiales	menB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000			iJN678.menB,iYL1228.KPN_02660	Bacteria	2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2	NA|NA|NA	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily
MAG.T22.39_00701	675635.Psed_5600	1.6e-43	183.7	Pseudonocardiales	menE		6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN9C@201174,4DYFK@85010,COG0318@1,COG0318@2	NA|NA|NA	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II
MAG.T22.39_00702	1184609.KILIM_039_00360	8e-80	303.9	Dermatophilaceae	menA	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006			iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737	Bacteria	2GJBS@201174,4F6JM@85018,COG1575@1,COG1575@2	NA|NA|NA	H	Belongs to the MenA family. Type 1 subfamily
MAG.T22.39_00704	1304876.AZVC01000009_gene3480	2.4e-15	88.2	Micrococcaceae													Bacteria	1WA3P@1268,2EGDD@1,2GR3X@201174,33A58@2	NA|NA|NA	S	Phospholipase_D-nuclease N-terminal
MAG.T22.39_00705	1048339.KB913029_gene2342	8.9e-85	320.5	Frankiales	ccsA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678											Bacteria	2GJR1@201174,4ESE9@85013,COG0755@1,COG0755@2	NA|NA|NA	O	Cytochrome c-type biogenesis protein
MAG.T22.39_00706	1120950.KB892801_gene1786	9.3e-132	477.2	Propionibacteriales	resB			ko:K07399					ko00000				Bacteria	2GMGH@201174,4DN12@85009,COG1333@1,COG1333@2	NA|NA|NA	O	ResB-like family
MAG.T22.39_00707	58123.JOFJ01000002_gene2616	4.7e-76	291.2	Streptosporangiales	ccdA			ko:K06196					ko00000,ko02000	5.A.1.2			Bacteria	2GJW3@201174,4EHWN@85012,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein transmembrane region
MAG.T22.39_00708	1237500.ANBA01000013_gene4116	2.7e-44	185.3	Streptosporangiales	resA			ko:K02199					ko00000,ko03110				Bacteria	2GP7J@201174,4EJ9T@85012,COG0526@1,COG0526@2	NA|NA|NA	CO	Thioredoxin-like
MAG.T22.39_00709	1463900.JOIX01000023_gene7089	3.2e-73	281.6	Actinobacteria		GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.1.3.3,3.1.3.73	ko:K02226,ko:K22305	ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130	M00122	R00582,R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMXF@201174,COG0406@1,COG0406@2	NA|NA|NA	G	phosphoglycerate mutase
MAG.T22.39_00710	1123320.KB889585_gene1861	1.7e-156	559.7	Actinobacteria	hemD	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJZ@201174,COG0007@1,COG0007@2,COG1587@1,COG1587@2	NA|NA|NA	H	Uroporphyrinogen-III synthase
MAG.T22.39_00711	471852.Tcur_4441	5.2e-74	284.3	Streptosporangiales	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K01926					ko00000,ko03000				Bacteria	2GMV2@201174,4EFVE@85012,COG2344@1,COG2344@2	NA|NA|NA	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MAG.T22.39_00712	1157640.AQWO01000012_gene366	2e-25	121.3	Actinobacteria													Bacteria	2IR0P@201174,COG0695@1,COG0695@2	NA|NA|NA	O	PFAM Glutaredoxin 2
MAG.T22.39_00713	1415166.NONO_c10600	2.8e-49	201.8	Nocardiaceae			2.3.1.189	ko:K03824,ko:K15520					ko00000,ko01000				Bacteria	2IKX0@201174,4G0F1@85025,COG3153@1,COG3153@2	NA|NA|NA	Q	Acetyltransferase (GNAT) family
MAG.T22.39_00715	1048339.KB913029_gene2324	6.4e-82	310.8	Frankiales	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K21830					ko00000				Bacteria	2GJW9@201174,4ERWE@85013,COG0560@1,COG0560@2	NA|NA|NA	E	HAD-superfamily subfamily IB hydrolase, TIGR01490
MAG.T22.39_00716	675635.Psed_5628	1.1e-106	393.3	Pseudonocardiales		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GJKH@201174,4E0YI@85010,COG0204@1,COG0204@2	NA|NA|NA	I	Acyltransferase
MAG.T22.39_00717	1120950.KB892801_gene1769	1.1e-93	350.1	Propionibacteriales	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0501	Bacteria	2GNT1@201174,4DPEE@85009,COG0451@1,COG0451@2	NA|NA|NA	GM	GDP-mannose 4,6 dehydratase
MAG.T22.39_00718	1394178.AWOO02000038_gene9074	3.9e-19	100.1	Streptosporangiales	xis												Bacteria	2GQGV@201174,4EKJX@85012,COG3311@1,COG3311@2	NA|NA|NA	K	Helix-turn-helix domain
MAG.T22.39_00719	28444.JODQ01000014_gene6728	1.2e-131	476.5	Streptosporangiales	acuC			ko:K04768					ko00000			iYO844.BSU29710	Bacteria	2GJUH@201174,4EGFY@85012,COG0123@1,COG0123@2	NA|NA|NA	BQ	Histone deacetylase domain
MAG.T22.39_00720	1229203.KI301992_gene131	2e-48	199.5	unclassified Actinobacteria (class)	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ7D@201174,3UWS1@52018,COG0345@1,COG0345@2	NA|NA|NA	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAG.T22.39_00721	1463936.JOJI01000018_gene7725	5.1e-31	141.7	Actinobacteria				ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130		R10507	RC00083	ko00000,ko00001,ko01000				Bacteria	2GJTK@201174,COG0506@1,COG0506@2	NA|NA|NA	E	Proline dehydrogenase
MAG.T22.39_00722	1054860.KB913030_gene3726	3e-25	122.1	Actinobacteria													Bacteria	2GP92@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_00723	1048339.KB913029_gene2307	6.9e-94	350.5	Frankiales													Bacteria	2GJ6E@201174,4ERMT@85013,COG1082@1,COG1082@2	NA|NA|NA	G	PFAM Xylose isomerase
MAG.T22.39_00724	1123322.KB904675_gene3035	2e-213	749.2	Actinobacteria	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132		ko:K12952					ko00000,ko01000	3.A.3.23			Bacteria	2GJJC@201174,COG0474@1,COG0474@2	NA|NA|NA	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC
MAG.T22.39_00725	1122611.KB903939_gene451	1.1e-103	383.3	Streptosporangiales	ppx	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	2GMME@201174,4EHJ0@85012,COG0248@1,COG0248@2	NA|NA|NA	FP	Ppx/GppA phosphatase family
MAG.T22.39_00726	397278.JOJN01000002_gene376	6.1e-84	317.4	Propionibacteriales													Bacteria	28IRH@1,2GJW6@201174,2Z8QX@2,4DP80@85009	NA|NA|NA		
MAG.T22.39_00727	1274.HX89_12450	3.5e-154	551.6	Dermacoccaceae	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04485					ko00000,ko03400				Bacteria	1ZVDB@145357,2GMQ0@201174,COG1066@1,COG1066@2	NA|NA|NA	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MAG.T22.39_00728	994479.GL877879_gene4471	2e-19	102.8	Pseudonocardiales													Bacteria	2I2R9@201174,4E4VU@85010,COG1572@1,COG1572@2	NA|NA|NA	NU	bacterial-type flagellum-dependent cell motility
MAG.T22.39_00729	43759.JNWK01000011_gene6216	3.9e-82	311.6	Actinobacteria	mutY			ko:K03575	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJD9@201174,COG1194@1,COG1194@2	NA|NA|NA	L	adenine glycosylase
MAG.T22.39_00730	1122611.KB903940_gene2055	5.2e-223	781.2	Streptosporangiales	ctpF	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.8	ko:K01537,ko:K12953					ko00000,ko01000	3.A.3,3.A.3.2			Bacteria	2GJJC@201174,4EGTA@85012,COG0474@1,COG0474@2	NA|NA|NA	P	Cation transporter/ATPase, N-terminus
MAG.T22.39_00732	243265.plu1434	2.8e-43	182.2	Gammaproteobacteria	kynA		1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000				Bacteria	1MW68@1224,1RXYM@1236,COG3483@1,COG3483@2	NA|NA|NA	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety
MAG.T22.39_00733	1123320.KB889697_gene8889	1e-144	520.4	Actinobacteria													Bacteria	2GJVW@201174,COG1574@1,COG1574@2	NA|NA|NA	E	amidohydrolase
MAG.T22.39_00734	1123023.JIAI01000003_gene2746	1.1e-110	406.8	Pseudonocardiales	hdaH												Bacteria	2GJUH@201174,4EEMY@85010,COG0123@1,COG0123@2	NA|NA|NA	BQ	Histone deacetylase domain
MAG.T22.39_00735	1120792.JAFV01000001_gene771	6.5e-238	830.5	Alphaproteobacteria			3.5.1.56	ko:K03418	ko00630,map00630		R02509	RC00111,RC00731	ko00000,ko00001,ko01000				Bacteria	1R4CP@1224,2TTHR@28211,COG3391@1,COG3391@2	NA|NA|NA	S	amine dehydrogenase activity
MAG.T22.39_00736	864051.BurJ1DRAFT_4588	1.8e-89	336.3	Betaproteobacteria				ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1Q360@1224,2VM28@28216,COG4177@1,COG4177@2	NA|NA|NA	U	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_00738	2002.JOEQ01000047_gene7246	1.2e-71	276.6	Streptosporangiales													Bacteria	2GIS7@201174,4EH0Q@85012,COG5011@1,COG5011@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2344)
MAG.T22.39_00739	367299.JOEE01000004_gene1257	5.3e-297	1026.5	Intrasporangiaceae													Bacteria	2GJY1@201174,4FFMS@85021,COG1032@1,COG1032@2	NA|NA|NA	C	Fe-S oxidoreductase
MAG.T22.39_00740	66897.DJ64_33385	5e-101	374.8	Actinobacteria	rodA			ko:K05837					ko00000,ko03036				Bacteria	2GK2G@201174,COG0772@1,COG0772@2	NA|NA|NA	D	Belongs to the SEDS family
MAG.T22.39_00741	1504319.GM45_5810	2e-193	682.6	unclassified Actinobacteria (class)	mrdA		3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501				ko00000,ko00001,ko01000,ko01011				Bacteria	2GJ61@201174,3UXBI@52018,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin-binding Protein dimerisation domain
MAG.T22.39_00742	105425.BBPL01000002_gene6550	2.4e-18	99.0	Streptacidiphilus	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K03571					ko00000,ko03036	9.B.157.1			Bacteria	2GN0I@201174,2NHBF@228398,COG2891@1,COG2891@2	NA|NA|NA	M	rod shape-determining protein (MreD)
MAG.T22.39_00743	1123320.KB889629_gene7889	1.2e-55	223.8	Actinobacteria	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030428,GO:0042546,GO:0043621,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944		ko:K03570					ko00000,ko03036	9.B.157.1			Bacteria	2GJN0@201174,COG1792@1,COG1792@2	NA|NA|NA	M	Involved in formation and maintenance of cell shape
MAG.T22.39_00744	351607.Acel_0748	6e-111	407.1	Frankiales	mreB			ko:K03569					ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1			Bacteria	2GMD1@201174,4ES3S@85013,COG1077@1,COG1077@2	NA|NA|NA	D	TIGRFAM Cell shape determining protein MreB Mrl
MAG.T22.39_00745	565045.NOR51B_1831	1.7e-08	65.9	unclassified Gammaproteobacteria													Bacteria	1JA31@118884,1RAIR@1224,1S6AX@1236,COG1216@1,COG1216@2	NA|NA|NA	H	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit
MAG.T22.39_00746	1215092.PA6_016_01270	2.2e-139	501.9	Pseudomonas aeruginosa group			4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000				Bacteria	1MXKV@1224,1RNJD@1236,1YJYJ@136841,COG0451@1,COG0451@2	NA|NA|NA	GM	Male sterility protein
MAG.T22.39_00748	479435.Kfla_5772	3.2e-08	67.4	Propionibacteriales													Bacteria	28YI8@1,2IE2Z@201174,2ZKC6@2,4DTGM@85009	NA|NA|NA		
MAG.T22.39_00749	314260.PB2503_11279	2e-36	159.8	Bacteria													Bacteria	COG2242@1,COG2242@2	NA|NA|NA	H	protein methyltransferase activity
MAG.T22.39_00750	1470593.BW43_03834	1.4e-47	197.2	Gammaproteobacteria				ko:K13001					ko00000,ko01000,ko01003,ko01005		GT4		Bacteria	1N9EV@1224,1RYRV@1236,COG0438@1,COG0438@2	NA|NA|NA	M	glycosyl transferase group 1
MAG.T22.39_00751	888060.HMPREF9081_2462	1.1e-28	134.0	Negativicutes													Bacteria	1VE6D@1239,2AJKK@1,31A7Q@2,4H7MI@909932	NA|NA|NA	S	Methyltransferase FkbM domain
MAG.T22.39_00753	1001240.GY21_17030	1.3e-57	229.9	Microbacteriaceae	ywdF	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	2IH3A@201174,4FP1W@85023,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T22.39_00754	1175306.GWL_46380	2.1e-21	109.8	Proteobacteria													Bacteria	1N3TN@1224,COG1216@1,COG1216@2	NA|NA|NA	Q	Pfam Glycosyl transferase family 2
MAG.T22.39_00755	59919.PMM1198	3.8e-19	102.8	Bacteria			2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100		R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003		GT39		Bacteria	COG5650@1,COG5650@2	NA|NA|NA	M	phosphatidylinositol metabolic process
MAG.T22.39_00756	180281.CPCC7001_302	6e-52	211.8	Cyanobacteria				ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	1G1VE@1117,COG0438@1,COG0438@2	NA|NA|NA	M	PFAM Glycosyl transferases group 1
MAG.T22.39_00757	1286631.X805_05730	4.1e-17	95.5	unclassified Burkholderiales													Bacteria	1KJW0@119065,1NB7J@1224,28JAC@1,2VNS0@28216,2Z956@2	NA|NA|NA		
MAG.T22.39_00760	312284.A20C1_06086	1.3e-45	191.0	Actinobacteria													Bacteria	2E19N@1,2IF2A@201174,32WPX@2	NA|NA|NA	S	Predicted membrane protein (DUF2142)
MAG.T22.39_00762	1305732.JAGG01000001_gene1920	5.1e-45	188.0	Microbacteriaceae	neuA		2.7.7.43,2.7.7.92	ko:K00983,ko:K21749	ko00520,ko01100,map00520,map01100		R01117,R04215	RC00152	ko00000,ko00001,ko01000				Bacteria	2I2ET@201174,4FNHK@85023,COG1083@1,COG1083@2	NA|NA|NA	M	Cytidylyltransferase
MAG.T22.39_00764	41431.PCC8801_3331	1.2e-10	73.9	Cyanobacteria	galE7		1.1.1.339	ko:K19180	ko00523,ko01130,map00523,map01130		R10190	RC00182	ko00000,ko00001,ko01000				Bacteria	1G3KY@1117,COG0451@1,COG0451@2	NA|NA|NA	GM	PFAM NAD dependent epimerase dehydratase family
MAG.T22.39_00767	269800.Tfu_0010	1.2e-83	316.6	Streptosporangiales	neuB		2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100		R01804,R04435	RC00159	ko00000,ko00001,ko01000				Bacteria	2GJC9@201174,4EHFD@85012,COG2089@1,COG2089@2	NA|NA|NA	M	NeuB family
MAG.T22.39_00768	1122137.AQXF01000007_gene3480	2.4e-25	122.9	Alphaproteobacteria													Bacteria	1R1H6@1224,2TZ23@28211,COG1196@1,COG1196@2	NA|NA|NA	D	Methyltransferase domain
MAG.T22.39_00769	1388763.O165_002710	2.8e-125	455.3	Pseudomonas putida group													Bacteria	1MUPN@1224,1RMCS@1236,1YZ0S@136845,COG0399@1,COG0399@2	NA|NA|NA	E	Belongs to the DegT DnrJ EryC1 family
MAG.T22.39_00770	234267.Acid_7497	1e-83	317.4	Acidobacteria			1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000				Bacteria	3Y3GR@57723,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T22.39_00771	497964.CfE428DRAFT_0087	2e-106	392.5	Verrucomicrobia													Bacteria	46US6@74201,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
MAG.T22.39_00772	234267.Acid_0561	1.1e-46	194.9	Bacteria													Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T22.39_00773	234267.Acid_0558	7e-67	260.8	Bacteria													Bacteria	COG2227@1,COG2227@2	NA|NA|NA	H	3-demethylubiquinone-9 3-O-methyltransferase activity
MAG.T22.39_00774	1205680.CAKO01000010_gene4008	1.8e-42	181.0	Alphaproteobacteria	MA20_37200												Bacteria	1QXYT@1224,2UGAK@28211,COG2242@1,COG2242@2	NA|NA|NA	H	Methyltransferase FkbM domain
MAG.T22.39_00776	331113.SNE_A16830	4.2e-29	135.2	Bacteria													Bacteria	COG2813@1,COG2813@2	NA|NA|NA	J	rRNA (guanine-N2-)-methyltransferase activity
MAG.T22.39_00777	1380393.JHVP01000011_gene3220	1.4e-14	88.2	Actinobacteria													Bacteria	2C825@1,2IGR2@201174,32RK8@2	NA|NA|NA		
MAG.T22.39_00778	494419.ALPM01000070_gene1679	2.2e-74	287.0	Micrococcaceae				ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	1WAP9@1268,2HXAQ@201174,COG1132@1,COG1132@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T22.39_00779	479433.Caci_8184	7.6e-13	82.4	Actinobacteria													Bacteria	2C825@1,2IGR2@201174,32RK8@2	NA|NA|NA		
MAG.T22.39_00780	1120950.KB892795_gene2301	3.8e-134	485.3	Propionibacteriales	capD	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	4.2.1.115,4.2.1.135,4.2.1.46	ko:K01710,ko:K15894,ko:K15912,ko:K19421	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R06513,R09697	RC00402,RC02609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIXM@201174,4DN3G@85009,COG1086@1,COG1086@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
MAG.T22.39_00781	1298863.AUEP01000004_gene2108	5.4e-30	138.7	Actinobacteria	wbpL		2.7.8.33,2.7.8.35	ko:K02851,ko:K13007			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	2GIT7@201174,COG0472@1,COG0472@2	NA|NA|NA	M	PFAM Glycosyl transferase family 4
MAG.T22.39_00782	649831.L083_2810	5e-59	235.0	Actinobacteria													Bacteria	2GQ4Y@201174,COG0451@1,COG0451@2	NA|NA|NA	GM	RmlD substrate binding domain
MAG.T22.39_00783	402777.KB235899_gene4904	2e-24	120.2	Oscillatoriales													Bacteria	1G4K3@1117,1HFSR@1150,COG4641@1,COG4641@2	NA|NA|NA	S	Glycosyl transferases group 1
MAG.T22.39_00784	1229780.BN381_110033	4e-82	311.2	Actinobacteria													Bacteria	2GP1D@201174,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T22.39_00785	234267.Acid_0618	8.3e-17	95.5	Bacteria													Bacteria	2CV66@1,2Z9R3@2	NA|NA|NA		
MAG.T22.39_00786	1429046.RR21198_5787	4.8e-37	161.8	Nocardiaceae													Bacteria	2I3WV@201174,4G8KF@85025,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyltransferase like family 2
MAG.T22.39_00787	367299.JOEE01000003_gene2955	1.9e-27	131.0	Intrasporangiaceae													Bacteria	2IKI5@201174,4FI9P@85021,COG4485@1,COG4485@2	NA|NA|NA	S	Bacterial membrane protein, YfhO
MAG.T22.39_00788	1194165.CAJF01000004_gene2831	9.5e-13	81.6	Actinobacteria													Bacteria	2DS2B@1,2I86V@201174,33E7G@2	NA|NA|NA		
MAG.T22.39_00789	404380.Gbem_2563	3.9e-34	152.1	Bacteria		GO:0003674,GO:0003824,GO:0016740,GO:0016757											Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T22.39_00790	765420.OSCT_1494	1.3e-31	144.8	Bacteria													Bacteria	2DTK7@1,33KQU@2	NA|NA|NA		
MAG.T22.39_00791	710696.Intca_2645	1.5e-105	390.6	Intrasporangiaceae													Bacteria	2GKI5@201174,4FI7P@85021,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase family
MAG.T22.39_00793	931627.MycrhDRAFT_5103	9.2e-96	356.7	Mycobacteriaceae	rfbF		2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100		R00956	RC00002	ko00000,ko00001,ko01000				Bacteria	235MN@1762,2GKHA@201174,COG1208@1,COG1208@2	NA|NA|NA	JM	Glucose-1-phosphate cytidylyltransferase
MAG.T22.39_00794	575540.Isop_0468	4.8e-36	158.3	Planctomycetes			2.1.1.95	ko:K05928	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07236,R07504,R10491,R10492	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000				Bacteria	2J55B@203682,COG0500@1,COG1215@1,COG1215@2,COG2226@2	NA|NA|NA	H	Methylase involved in ubiquinone menaquinone biosynthesis
MAG.T22.39_00795	596153.Alide_1984	3.8e-75	288.5	Comamonadaceae	ykcC		2.4.1.83	ko:K00721,ko:K20534	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003,ko01005,ko02000	4.D.2.1.9	GT2		Bacteria	1MWE5@1224,2VIY2@28216,4AB91@80864,COG0463@1,COG0463@2	NA|NA|NA	M	glycosyl transferase family 2
MAG.T22.39_00796	471852.Tcur_2350	9.4e-42	177.2	Streptosporangiales	ppm1		2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	2I2FA@201174,4EGDZ@85012,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
MAG.T22.39_00799	931627.MycrhDRAFT_5118	1.7e-09	70.9	Mycobacteriaceae													Bacteria	236W8@1762,2A18W@1,2ICYV@201174,30PFA@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T22.39_00801	298654.FraEuI1c_5630	4.6e-98	365.2	Frankiales	glcD2	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.2.4	ko:K00102	ko00620,map00620		R00197	RC00044	ko00000,ko00001,ko01000				Bacteria	2GKI9@201174,4ESN2@85013,COG0277@1,COG0277@2	NA|NA|NA	C	PFAM FAD linked oxidase
MAG.T22.39_00803	907348.TresaDRAFT_0802	1.5e-51	209.5	Spirochaetes	nt5e		3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	2J7WT@203691,COG0546@1,COG0546@2	NA|NA|NA	S	PFAM Haloacid dehalogenase-like hydrolase
MAG.T22.39_00804	1906.SFRA_12910	3.8e-62	245.0	Actinobacteria	glpQ		3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000				Bacteria	2GMMS@201174,COG0584@1,COG0584@2	NA|NA|NA	C	glycerophosphoryl diester phosphodiesterase
MAG.T22.39_00805	1268622.AVS7_03676	1.3e-159	569.3	Comamonadaceae			2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100		R01804,R04435	RC00159	ko00000,ko00001,ko01000			iAF987.Gmet_0455	Bacteria	1MWG3@1224,2VHMH@28216,4AG7R@80864,COG2089@1,COG2089@2	NA|NA|NA	M	NeuB family
MAG.T22.39_00806	710687.KI912270_gene2451	9e-44	184.1	Mycobacteriaceae													Bacteria	236KZ@1762,2I93Q@201174,COG0451@1,COG0451@2	NA|NA|NA	GM	NAD dependent epimerase/dehydratase family
MAG.T22.39_00807	1489678.RDMS_08175	2e-60	240.0	Deinococcus-Thermus	epsL			ko:K19428					ko00000,ko01000				Bacteria	1WIX1@1297,COG0438@1,COG0438@2,COG2148@1,COG2148@2	NA|NA|NA	GM	COGs COG2148 Sugar transferase involved in lipopolysaccharide synthesis
MAG.T22.39_00808	1430440.MGMSRv2_3393	1.1e-22	114.4	Rhodospirillales													Bacteria	1RF49@1224,2JSYX@204441,2U7J6@28211,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T22.39_00809	316067.Geob_2133	6.4e-46	191.8	Deltaproteobacteria													Bacteria	1MUIZ@1224,2WTT4@28221,4378H@68525,COG0438@1,COG0438@2	NA|NA|NA	H	Glycosyl transferases group 1
MAG.T22.39_00810	1123368.AUIS01000027_gene1355	7.4e-172	610.5	Gammaproteobacteria				ko:K00612					ko00000,ko01000				Bacteria	1MWBA@1224,1RNN4@1236,COG2192@1,COG2192@2	NA|NA|NA	O	carbamoyl transferase, NodU family
MAG.T22.39_00812	316067.Geob_1473	2e-37	163.3	Deltaproteobacteria													Bacteria	1QIR3@1224,28IIB@1,2WW03@28221,2Z8JE@2,430WH@68525	NA|NA|NA	S	Glycosyltransferase family 10 (fucosyltransferase) C-term
MAG.T22.39_00813	1121933.AUHH01000009_gene773	9.8e-11	74.7	Actinobacteria													Bacteria	2DES2@1,2HC5N@201174,2ZP1E@2	NA|NA|NA		
MAG.T22.39_00814	931627.MycrhDRAFT_5105	1.2e-165	590.1	Mycobacteriaceae			2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	23A16@1762,2I8MB@201174,COG0028@1,COG0028@2	NA|NA|NA	EH	Thiamine pyrophosphate enzyme, central domain
MAG.T22.39_00815	216594.MMAR_2330	5.9e-43	181.0	Mycobacteriaceae													Bacteria	23CX3@1762,2HETI@201174,COG1028@1,COG1028@2	NA|NA|NA	C	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_00816	931627.MycrhDRAFT_5107	2.8e-90	339.0	Mycobacteriaceae	aroB		2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	23CCR@1762,2H2HG@201174,COG0337@1,COG0337@2	NA|NA|NA	H	3-dehydroquinate synthase
MAG.T22.39_00817	931627.MycrhDRAFT_5108	2.7e-38	166.4	Bacteria			2.7.1.12,2.7.1.14	ko:K00851,ko:K11214	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00710,map01100,map01110,map01120,map01130,map01200		R01737,R01844	RC00002,RC00017,RC00608	ko00000,ko00001,ko01000				Bacteria	COG1070@1,COG1070@2	NA|NA|NA	G	xylulokinase activity
MAG.T22.39_00818	931627.MycrhDRAFT_5120	1.6e-10	74.3	Mycobacteriaceae													Bacteria	236W8@1762,2A18W@1,2ICYV@201174,30PFA@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T22.39_00819	195253.Syn6312_1981	1.7e-10	74.3	Cyanobacteria													Bacteria	1GBCR@1117,2DECI@1,32U34@2	NA|NA|NA	S	Uncharacterised nucleotidyltransferase
MAG.T22.39_00820	240016.ABIZ01000001_gene4575	2e-30	140.2	Bacteria			2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100		R00292	RC00005	ko00000,ko00001,ko01000,ko01003		GT4		Bacteria	COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
MAG.T22.39_00821	1437425.CSEC_1827	4.4e-25	121.7	Bacteria													Bacteria	COG1216@1,COG1216@2	NA|NA|NA	V	Glycosyl transferase, family 2
MAG.T22.39_00822	1173028.ANKO01000112_gene4868	8e-10	70.5	Oscillatoriales													Bacteria	1GCRI@1117,1HFKH@1150,2E7MG@1,3323C@2	NA|NA|NA	S	Coenzyme PQQ synthesis protein D (PqqD)
MAG.T22.39_00824	643473.KB235930_gene3903	1.7e-37	162.9	Nostocales													Bacteria	1G2ZC@1117,1HJ8R@1161,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
MAG.T22.39_00825	203124.Tery_3753	4.5e-57	228.4	Oscillatoriales	CP_1016			ko:K01421,ko:K06219					ko00000				Bacteria	1FZUY@1117,1H72J@1150,COG0438@1,COG0438@2,COG0500@1,COG1215@1,COG1215@2,COG1511@1,COG1511@2,COG2226@2,COG2227@1,COG2227@2,COG3914@1,COG3914@2	NA|NA|NA	M	glycosyl transferase
MAG.T22.39_00826	1121033.AUCF01000004_gene4627	2.1e-17	96.7	Rhodospirillales													Bacteria	1RDZ8@1224,2DBCR@1,2JWFQ@204441,2U8XS@28211,2Z8FA@2	NA|NA|NA		
MAG.T22.39_00827	713586.KB900536_gene1743	5.2e-20	105.9	Gammaproteobacteria													Bacteria	1N6ZU@1224,1SSTM@1236,COG1493@1,COG1493@2	NA|NA|NA	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MAG.T22.39_00828	235985.BBPN01000035_gene749	5.3e-180	637.5	Streptacidiphilus			1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,2NGMW@228398,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T22.39_00829	28444.JODQ01000001_gene2778	1.8e-137	496.1	Streptosporangiales													Bacteria	2GJQ9@201174,4EFKQ@85012,COG0665@1,COG0665@2	NA|NA|NA	E	FAD dependent oxidoreductase
MAG.T22.39_00830	28444.JODQ01000001_gene2780	1.3e-100	373.2	Streptosporangiales	potA		3.6.3.31	ko:K11072,ko:K11076	ko02010,map02010	M00299,M00300			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1,3.A.1.11.2			Bacteria	2GJCM@201174,4EIH8@85012,COG3842@1,COG3842@2	NA|NA|NA	E	TOBE domain
MAG.T22.39_00831	653045.Strvi_4835	5.6e-85	320.9	Actinobacteria	potC			ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2HXTT@201174,COG1177@1,COG1177@2	NA|NA|NA	E	PFAM binding-protein-dependent transport systems inner membrane component
MAG.T22.39_00832	653045.Strvi_4834	4.2e-92	344.7	Actinobacteria				ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GJ5G@201174,COG1176@1,COG1176@2	NA|NA|NA	E	ABC-type spermidine putrescine transport system, permease component I
MAG.T22.39_00833	653045.Strvi_4833	1.6e-117	429.5	Actinobacteria				ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1			Bacteria	2ID4S@201174,COG0687@1,COG0687@2	NA|NA|NA	E	Bacterial extracellular solute-binding protein
MAG.T22.39_00834	235985.BBPN01000035_gene747	6.5e-66	257.3	Streptacidiphilus													Bacteria	2IAKY@201174,2NF5Z@228398,COG1309@1,COG1309@2	NA|NA|NA	K	BetI-type transcriptional repressor, C-terminal
MAG.T22.39_00835	235985.BBPN01000035_gene746	1.4e-184	652.5	Streptacidiphilus													Bacteria	2GJN7@201174,2NK5V@228398,COG1819@1,COG1819@2	NA|NA|NA	CG	UDP-glucoronosyl and UDP-glucosyl transferase
MAG.T22.39_00836	235985.BBPN01000035_gene745	5.5e-61	241.9	Actinobacteria			2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100		R09945	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	2IBUS@201174,COG3281@1,COG3281@2	NA|NA|NA	G	Aminoglycoside phosphotransferase
MAG.T22.39_00837	1194972.MVAC_18630	5.7e-82	311.2	Mycobacteriaceae													Bacteria	233QK@1762,2IBP7@201174,COG2222@1,COG2222@2	NA|NA|NA	M	SIS domain
MAG.T22.39_00838	1223523.H340_20583	8.8e-07	62.4	Actinobacteria			1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000				Bacteria	2HSAF@201174,COG0167@1,COG0167@2	NA|NA|NA	F	dihydroorotate dehydrogenase activity
MAG.T22.39_00840	1158762.KB898065_gene1166	4.4e-110	404.8	Gammaproteobacteria				ko:K07133					ko00000				Bacteria	1MWBT@1224,1RRXR@1236,COG1373@1,COG1373@2	NA|NA|NA	S	ATPase, AAA superfamily
MAG.T22.39_00842	1034943.BN1094_01632	1.4e-28	133.7	Legionellales													Bacteria	1JCME@118969,1RA24@1224,1SXPG@1236,COG2324@1,COG2324@2	NA|NA|NA	S	Carotenoid biosynthesis protein
MAG.T22.39_00849	66373.JOFQ01000008_gene299	5.8e-100	370.9	Actinobacteria	secA_2												Bacteria	2GJ7F@201174,COG3012@1,COG3012@2	NA|NA|NA	S	SEC-C motif
MAG.T22.39_00850	1146883.BLASA_2185	6.1e-36	157.1	Frankiales													Bacteria	2E73E@1,2IRHV@201174,331MX@2,4EVZR@85013	NA|NA|NA		
MAG.T22.39_00851	1146883.BLASA_2186	8.2e-11	73.6	Actinobacteria													Bacteria	2H0F6@201174,COG4634@1,COG4634@2	NA|NA|NA		
MAG.T22.39_00853	479431.Namu_2601	5.1e-45	189.1	Actinobacteria													Bacteria	2GIUM@201174,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator superfamily
MAG.T22.39_00858	179408.Osc7112_3648	2.2e-175	622.5	Oscillatoriales													Bacteria	1G2T7@1117,1H845@1150,COG1404@1,COG1404@2	NA|NA|NA	O	Subtilase family
MAG.T22.39_00859	395961.Cyan7425_0514	1.6e-09	68.2	Cyanobacteria													Bacteria	1G9T3@1117,2CCEW@1,331MT@2	NA|NA|NA		
MAG.T22.39_00861	696747.NIES39_O00960	3.9e-93	349.4	Oscillatoriales	acyG												Bacteria	1G2T7@1117,1H963@1150,COG0778@1,COG0778@2,COG1404@1,COG1404@2	NA|NA|NA	O	Subtilase family
MAG.T22.39_00862	118161.KB235922_gene5516	3e-35	157.1	Cyanobacteria	acyG												Bacteria	1G2T7@1117,COG0778@1,COG0778@2,COG1404@1,COG1404@2	NA|NA|NA	O	Cyanobactin maturation protease, PatA PatG family
MAG.T22.39_00868	179408.Osc7112_3651	1.7e-121	443.7	Oscillatoriales				ko:K09136					ko00000,ko03009				Bacteria	1G28K@1117,1H9RH@1150,COG1944@1,COG1944@2	NA|NA|NA	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding
MAG.T22.39_00869	1146883.BLASA_0240	2.2e-34	152.5	Frankiales													Bacteria	2GNR0@201174,4EVWD@85013,COG2119@1,COG2119@2	NA|NA|NA	S	Uncharacterized protein family UPF0016
MAG.T22.39_00870	105425.BBPL01000038_gene2911	1.5e-59	237.3	Streptacidiphilus													Bacteria	2DBVK@1,2H5Z5@201174,2NEQI@228398,2ZBBH@2	NA|NA|NA		
MAG.T22.39_00871	351607.Acel_2106	9e-29	133.7	Frankiales													Bacteria	2IMXX@201174,4ET89@85013,COG1196@1,COG1196@2	NA|NA|NA	D	Protein of unknown function (DUF4446)
MAG.T22.39_00872	1120950.KB892812_gene6976	1.4e-85	323.2	Propionibacteriales	pheA		1.3.1.12,4.2.1.51,5.4.99.5	ko:K04517,ko:K04518,ko:K14170	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715,R01728	RC00125,RC00360,RC03116	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJQ5@201174,4DN8Z@85009,COG0077@1,COG0077@2	NA|NA|NA	E	Prephenate dehydratase
MAG.T22.39_00873	351607.Acel_0415	2.9e-134	485.0	Frankiales	rfbB		4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNDU@201174,4ERZI@85013,COG1088@1,COG1088@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MAG.T22.39_00874	1463858.JOHR01000009_gene3366	1e-87	330.1	Actinobacteria	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNY8@201174,COG1091@1,COG1091@2	NA|NA|NA	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MAG.T22.39_00876	590998.Celf_3602	2.9e-48	199.1	Cellulomonadaceae													Bacteria	2GP42@201174,4F109@85016,COG0561@1,COG0561@2	NA|NA|NA	S	PFAM Haloacid dehalogenase domain protein hydrolase type 3
MAG.T22.39_00877	1348663.KCH_40850	1.1e-162	579.7	Kitasatospora	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GIWP@201174,2M1YW@2063,COG0172@1,COG0172@2	NA|NA|NA	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MAG.T22.39_00878	926569.ANT_22220	1.9e-40	172.6	Chloroflexi				ko:K07117					ko00000				Bacteria	2G9DE@200795,COG2940@1,COG2940@2	NA|NA|NA	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
MAG.T22.39_00879	1133849.O3I_000940	8e-113	413.7	Nocardiaceae	qor		1.6.5.5	ko:K00344					ko00000,ko01000				Bacteria	2GN47@201174,4FVY2@85025,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T22.39_00880	479431.Namu_4967	3.7e-98	365.2	Frankiales	kch		3.6.1.22	ko:K03426,ko:K10716	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6			Bacteria	2GKB8@201174,4ERFU@85013,COG1226@1,COG1226@2	NA|NA|NA	P	Ion channel
MAG.T22.39_00881	649831.L083_5861	5.8e-57	228.0	Micromonosporales	MA20_18170			ko:K07090					ko00000				Bacteria	2GNW8@201174,4DCJQ@85008,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T22.39_00882	1157637.KB892098_gene2061	1.7e-46	193.7	Actinobacteria	moaA2		2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	2GP1B@201174,COG0303@1,COG0303@2	NA|NA|NA	H	molybdopterin
MAG.T22.39_00883	1089544.KB912942_gene1813	2.8e-20	105.5	Actinobacteria	paaE	GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	1.18.1.3	ko:K00529,ko:K02613	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783,R09838	RC00098,RC02690	br01602,ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A1479	Bacteria	2GKGS@201174,COG1018@1,COG1018@2,COG4097@1,COG4097@2	NA|NA|NA	C	Oxidoreductase FAD-binding domain
MAG.T22.39_00884	1089544.KB912942_gene1812	1.7e-38	166.8	Pseudonocardiales	apbE		2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	2H74Y@201174,4DYZM@85010,COG1477@1,COG1477@2	NA|NA|NA	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
MAG.T22.39_00887	68194.JNXR01000003_gene3326	3.6e-59	235.0	Actinobacteria													Bacteria	2GKJK@201174,COG0745@1,COG0745@2	NA|NA|NA	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MAG.T22.39_00888	1906.SFRA_14220	1.1e-40	174.5	Actinobacteria	qseC	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K02484,ko:K07637,ko:K07643,ko:K07645,ko:K07649,ko:K07653	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00444,M00451,M00453,M00457,M00460,M00709,M00721,M00722,M00723,M00724,M00744			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Bacteria	2I2VJ@201174,COG0642@1,COG0642@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_00889	350054.Mflv_4765	3.3e-27	129.0	Mycobacteriaceae	wbyL			ko:K13002					ko00000,ko01000,ko01003,ko01005		GT2		Bacteria	23FDR@1762,2I60S@201174,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T22.39_00890	526227.Mesil_0189	1.9e-100	372.9	Deinococcus-Thermus	lhgO		1.1.99.2	ko:K00109,ko:K15736	ko00650,map00650		R03534	RC00031	ko00000,ko00001,ko01000				Bacteria	1WMNW@1297,COG0579@1,COG0579@2	NA|NA|NA	S	FAD dependent oxidoreductase
MAG.T22.39_00891	1122138.AQUZ01000035_gene6519	7.9e-59	233.8	Propionibacteriales													Bacteria	2GJE6@201174,4DP53@85009,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T22.39_00892	1146883.BLASA_2954	1e-65	257.7	Frankiales													Bacteria	2GK1J@201174,4ERY7@85013,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T22.39_00893	1385518.N798_08600	9.2e-09	67.4	Intrasporangiaceae	lpqB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944											Bacteria	2IRGJ@201174,4FH95@85021,COG5401@1,COG5401@2	NA|NA|NA	S	Sporulation and spore germination
MAG.T22.39_00894	1391646.AVSU01000010_gene88	4.1e-23	115.2	Peptostreptococcaceae	MA20_24010		3.5.1.28,6.1.1.12	ko:K01447,ko:K01876,ko:K21471,ko:K21472	ko00970,map00970	M00359,M00360	R04112,R05577	RC00055,RC00064,RC00141,RC00523	ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko03016,ko03029				Bacteria	1V9ZW@1239,249UE@186801,25SRB@186804,COG0791@1,COG0791@2,COG3807@1,COG3807@2	NA|NA|NA	M	COG COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MAG.T22.39_00895	479435.Kfla_3091	4.3e-34	152.5	Propionibacteriales				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJV2@201174,4DQVU@85009,COG2244@1,COG2244@2	NA|NA|NA	S	polysaccharide biosynthetic process
MAG.T22.39_00896	1449346.JQMO01000002_gene2057	8e-52	210.3	Kitasatospora	pfs		3.2.2.1,3.2.2.9	ko:K01239,ko:K01243	ko00230,ko00270,ko00760,ko01100,ko01230,map00230,map00270,map00760,map01100,map01230	M00034,M00609	R00194,R01245,R01273,R01401,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko00002,ko01000				Bacteria	2IMZ7@201174,2M2N2@2063,COG0775@1,COG0775@2	NA|NA|NA	F	Phosphorylase superfamily
MAG.T22.39_00898	118163.Ple7327_4660	8.2e-13	80.5	Cyanobacteria	crtO			ko:K10212	ko00906,map00906		R07656	RC00041	ko00000,ko00001,ko01000				Bacteria	1G5EB@1117,2E9V0@1,3340V@2	NA|NA|NA	S	carotenoid biosynthetic process
MAG.T22.39_00899	1121381.JNIV01000001_gene2856	1.1e-57	230.3	Bacteria			3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130		R00552	RC00177	ko00000,ko00001,ko01000				Bacteria	COG1834@1,COG1834@2	NA|NA|NA	E	dimethylargininase activity
MAG.T22.39_00900	463191.SSEG_04870	6.7e-126	457.2	Actinobacteria			1.1.1.1	ko:K13953,ko:K13979	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	2GNVQ@201174,COG1064@1,COG1064@2	NA|NA|NA	S	alcohol dehydrogenase
MAG.T22.39_00901	1122609.AUGT01000005_gene1601	4.5e-134	484.6	Propionibacteriales													Bacteria	2GK0F@201174,4DTCD@85009,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, C-terminal alpha/beta domain
MAG.T22.39_00902	1146883.BLASA_4759	3.3e-53	215.7	Frankiales													Bacteria	2GKVT@201174,4EWMM@85013,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_00903	1246995.AFR_34860	2.3e-103	381.7	Micromonosporales	ppgK		2.7.1.2,2.7.1.63,5.3.1.9	ko:K00845,ko:K00886,ko:K01810	ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114,M00549	R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321	RC00002,RC00017,RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJA0@201174,4DCFF@85008,COG1940@1,COG1940@2	NA|NA|NA	GK	ROK family
MAG.T22.39_00906	1403948.Q618_VCMC00001G1129	5.8e-24	116.7	Actinobacteria													Bacteria	2H95K@201174,COG3093@1,COG3093@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_00907	1028801.RG1141_CH14410	6.8e-33	146.4	Rhizobiaceae				ko:K07334					ko00000,ko02048				Bacteria	1MZ4I@1224,2VCRH@28211,4BFUW@82115,COG3549@1,COG3549@2	NA|NA|NA	S	RelE-like toxin of type II toxin-antitoxin system HigB
MAG.T22.39_00909	935866.JAER01000005_gene60	4.5e-43	180.6	Propionibacteriales													Bacteria	2IKPX@201174,4DRBT@85009,COG4898@1,COG4898@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2200)
MAG.T22.39_00910	1081644.IMCC13023_00510	4.4e-179	634.4	Microbacteriaceae	phrB	GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363		ko:K06876					ko00000				Bacteria	2GMF6@201174,4FKWJ@85023,COG3046@1,COG3046@2	NA|NA|NA	S	Deoxyribodipyrimidine photo-lyase-related protein
MAG.T22.39_00911	443218.AS9A_4297	4.6e-62	245.4	Mycobacteriaceae													Bacteria	233DK@1762,2GJ8V@201174,COG2124@1,COG2124@2	NA|NA|NA	C	cytochrome p450
MAG.T22.39_00913	216594.MMAR_2335	6.2e-185	653.7	Mycobacteriaceae	rfbH		1.17.1.1,4.2.1.164	ko:K12452,ko:K13328	ko00520,ko00523,ko01130,map00520,map00523,map01130	M00802	R03391,R03392,R08930	RC00230,RC00704	ko00000,ko00001,ko00002,ko01000				Bacteria	238GR@1762,2GKD7@201174,COG0399@1,COG0399@2	NA|NA|NA	M	Belongs to the DegT DnrJ EryC1 family
MAG.T22.39_00914	525909.Afer_1542	2.2e-83	316.2	Acidimicrobiia	ndh		1.6.99.3	ko:K03885	ko00190,map00190				ko00000,ko00001,ko01000				Bacteria	2GJFE@201174,4CMSI@84992,COG1252@1,COG1252@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase
MAG.T22.39_00915	1504319.GM45_0300	2.4e-67	262.3	unclassified Actinobacteria (class)	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2H4UC@201174,3UWPS@52018,COG1192@1,COG1192@2	NA|NA|NA	D	AAA domain
MAG.T22.39_00916	1211115.ALIQ01000026_gene702	3.8e-37	161.8	Alphaproteobacteria				ko:K03611					ko00000,ko03110	5.A.2.1			Bacteria	1RKPG@1224,2U89W@28211,COG1495@1,COG1495@2	NA|NA|NA	O	Disulfide bond formation protein DsbB
MAG.T22.39_00918	397278.JOJN01000003_gene1887	7.4e-110	404.1	Propionibacteriales	pntAA		1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2I2FZ@201174,4DNG1@85009,COG3288@1,COG3288@2	NA|NA|NA	C	NAD(P) transhydrogenase, alpha subunit
MAG.T22.39_00919	1115632.JAFW01000001_gene2138	1e-26	125.9	Actinobacteria	pntAB		1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2IKR9@201174,COG3288@1,COG3288@2	NA|NA|NA	C	NADP transhydrogenase
MAG.T22.39_00920	479433.Caci_8567	1.3e-148	533.1	Actinobacteria	pntB		1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000				Bacteria	2GNKB@201174,COG1282@1,COG1282@2	NA|NA|NA	C	the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MAG.T22.39_00921	196162.Noca_0275	1.9e-78	298.9	Propionibacteriales	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000				Bacteria	2GPJE@201174,4DPRI@85009,COG0035@1,COG0035@2	NA|NA|NA	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MAG.T22.39_00922	935866.JAER01000004_gene3855	1.3e-26	126.3	Propionibacteriales													Bacteria	2BM8T@1,2IG06@201174,32FSI@2,4DR8K@85009	NA|NA|NA	S	tRNA adenosine
MAG.T22.39_00923	1172186.KB911463_gene3306	3.8e-41	174.5	Mycobacteriaceae	tadA		3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19	ko:K01485,ko:K01563,ko:K04075,ko:K11991	ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120		R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223	RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	238U6@1762,2IM3Z@201174,COG0590@1,COG0590@2	NA|NA|NA	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MAG.T22.39_00924	1184607.AUCHE_16_00080	5.2e-14	84.7	Dermatophilaceae													Bacteria	2DW2X@1,2H1G8@201174,33YAQ@2,4F81V@85018	NA|NA|NA	S	LytR cell envelope-related transcriptional attenuator
MAG.T22.39_00925	714083.JH370377_gene2514	7.6e-175	620.5	Microbacteriaceae	gatA3		3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120		R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029				Bacteria	2GMND@201174,4FMP2@85023,COG0154@1,COG0154@2	NA|NA|NA	J	Amidase
MAG.T22.39_00926	1487953.JMKF01000065_gene4689	3.9e-31	141.7	Oscillatoriales	yahN	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03329					ko00000,ko02000	2.A.76.1.3			Bacteria	1G59K@1117,1HAV4@1150,COG1280@1,COG1280@2	NA|NA|NA	E	LysE type translocator
MAG.T22.39_00929	661478.OP10G_2987	3.9e-13	81.3	Bacteria													Bacteria	2ADWZ@1,313P3@2	NA|NA|NA		
MAG.T22.39_00930	1123320.KB889692_gene127	2.8e-151	542.3	Actinobacteria	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJKA@201174,COG2812@1,COG2812@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MAG.T22.39_00931	479435.Kfla_0409	4.6e-87	327.4	Propionibacteriales	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K06187	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	2GJY0@201174,4DP0B@85009,COG0353@1,COG0353@2	NA|NA|NA	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MAG.T22.39_00932	469371.Tbis_3528	1.8e-165	589.0	Pseudonocardiales	ask		1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN0G@201174,4DYQ8@85010,COG0527@1,COG0527@2	NA|NA|NA	E	Belongs to the aspartokinase family
MAG.T22.39_00933	1416759.AYMR01000021_gene181	2.8e-140	505.0	Microbacteriaceae	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3708c	Bacteria	2GJJ8@201174,4FKI5@85023,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MAG.T22.39_00934	1158756.AQXQ01000012_gene1837	1.7e-12	80.1	Bacteria													Bacteria	2DSUH@1,33HGK@2	NA|NA|NA	S	Sulfotransferase family
MAG.T22.39_00937	1032480.MLP_07200	2.2e-10	71.6	Actinobacteria													Bacteria	2ERPP@1,2GYWR@201174,33J91@2	NA|NA|NA		
MAG.T22.39_00938	2002.JOEQ01000005_gene3740	6e-164	583.6	Streptosporangiales	acdS		3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270		R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000				Bacteria	2GIV5@201174,4EJUH@85012,COG2515@1,COG2515@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T22.39_00940	1184607.AUCHE_21_00250	2.5e-18	98.2	Dermatophilaceae				ko:K07171					ko00000,ko01000,ko02048				Bacteria	2GUT3@201174,4F83U@85018,COG2337@1,COG2337@2	NA|NA|NA	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system
MAG.T22.39_00942	66897.DJ64_06495	4e-87	328.2	Actinobacteria	ykuE			ko:K07098					ko00000				Bacteria	2GJHT@201174,COG1408@1,COG1408@2	NA|NA|NA	S	metallophosphoesterase
MAG.T22.39_00943	1463845.JOIG01000008_gene3904	8.9e-38	163.3	Actinobacteria	yqeY			ko:K09117					ko00000				Bacteria	2IFFJ@201174,COG1610@1,COG1610@2	NA|NA|NA	S	GatB YqeY
MAG.T22.39_00944	1504319.GM45_3810	3.2e-97	362.5	unclassified Actinobacteria (class)	pon1		2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	2GK21@201174,3UW69@52018,COG0744@1,COG0744@2	NA|NA|NA	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MAG.T22.39_00945	312153.Pnuc_1139	2.2e-57	228.4	Burkholderiaceae	fumA		4.2.1.2	ko:K01676,ko:K01677,ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Bacteria	1K289@119060,1MUV9@1224,2VIP7@28216,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate
MAG.T22.39_00946	2002.JOEQ01000004_gene2737	2e-27	127.9	Streptosporangiales	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	2GQI6@201174,4EK70@85012,COG0636@1,COG0636@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAG.T22.39_00947	1123320.KB889571_gene5468	8.9e-73	280.4	Actinobacteria	atpB			ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1			Bacteria	2H3PR@201174,COG0356@1,COG0356@2	NA|NA|NA	C	it plays a direct role in the translocation of protons across the membrane
MAG.T22.39_00948	1123320.KB889571_gene5467	5.8e-08	63.9	Bacteria	atpI			ko:K02116					ko00000,ko00194	3.A.2.1			Bacteria	COG5336@1,COG5336@2	NA|NA|NA	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
MAG.T22.39_00949	1122611.KB903996_gene7577	1e-16	93.2	Streptosporangiales	atpI			ko:K02116					ko00000,ko00194	3.A.2.1			Bacteria	2BJAR@1,2IFU9@201174,32DKN@2,4EK3Y@85012	NA|NA|NA		
MAG.T22.39_00950	1504319.GM45_6060	1.1e-89	337.0	unclassified Actinobacteria (class)	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851			R08856	RC00002	ko00000,ko01000,ko01003,ko01005				Bacteria	2GIT7@201174,3UWGE@52018,COG0472@1,COG0472@2	NA|NA|NA	M	Glycosyl transferase family 4
MAG.T22.39_00951	656024.FsymDg_3853	5.6e-183	647.1	Frankiales	glyA		2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK7U@201174,4ERC5@85013,COG0112@1,COG0112@2	NA|NA|NA	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MAG.T22.39_00952	479433.Caci_1207	6.9e-28	131.0	Actinobacteria	ywlC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	2GK2X@201174,COG0009@1,COG0009@2	NA|NA|NA	J	Belongs to the SUA5 family
MAG.T22.39_00953	710111.FraQA3DRAFT_5662	3.5e-60	238.8	Frankiales	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493			R10806	RC00003,RC03279	ko00000,ko01000,ko03012				Bacteria	2GMH1@201174,4ESEI@85013,COG2890@1,COG2890@2	NA|NA|NA	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MAG.T22.39_00954	44060.JODL01000001_gene3087	1.5e-149	535.8	Actinobacteria	prfA			ko:K02835					ko00000,ko03012				Bacteria	2GJWG@201174,COG0216@1,COG0216@2	NA|NA|NA	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MAG.T22.39_00955	1122609.AUGT01000021_gene1233	4.2e-30	136.7	Propionibacteriales	rpmE			ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ4I@201174,4DRQR@85009,COG0254@1,COG0254@2	NA|NA|NA	J	Ribosomal protein L31
MAG.T22.39_00956	1048339.KB913029_gene3381	1.6e-185	656.0	Frankiales	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03628	ko03018,map03018				ko00000,ko00001,ko03019,ko03021				Bacteria	2GIWY@201174,4ERDG@85013,COG1158@1,COG1158@2	NA|NA|NA	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MAG.T22.39_00957	1210046.B277_10359	8.5e-72	277.3	Intrasporangiaceae	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620	Bacteria	2GKIW@201174,4FE3Y@85021,COG0083@1,COG0083@2	NA|NA|NA	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MAG.T22.39_00958	953739.SVEN_5007	1.2e-141	509.6	Actinobacteria	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250	Bacteria	2GJ5F@201174,COG0498@1,COG0498@2	NA|NA|NA	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAG.T22.39_00959	1504319.GM45_5985	6.2e-145	520.8	unclassified Actinobacteria (class)	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1294,iSB619.SA_RS06610	Bacteria	2GIX9@201174,3UWE2@52018,COG0460@1,COG0460@2	NA|NA|NA	E	Homoserine dehydrogenase
MAG.T22.39_00960	471852.Tcur_3940	5.6e-160	570.9	Streptosporangiales	lysA		4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKAI@201174,4EH7X@85012,COG0019@1,COG0019@2	NA|NA|NA	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MAG.T22.39_00961	479435.Kfla_5068	1.7e-200	705.7	Propionibacteriales	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iAF987.Gmet_1434	Bacteria	2GKQ3@201174,4DPKA@85009,COG0018@1,COG0018@2	NA|NA|NA	J	Arginyl tRNA synthetase N terminal dom
MAG.T22.39_00962	1385518.N798_02415	1.1e-24	118.6	Intrasporangiaceae	cspC			ko:K03704					ko00000,ko03000				Bacteria	2GQRU@201174,4FH9F@85021,COG1278@1,COG1278@2	NA|NA|NA	K	Cold-shock protein
MAG.T22.39_00963	314278.NB231_07747	2e-11	76.6	Chromatiales				ko:K07058					ko00000				Bacteria	1MXQA@1224,1RP8E@1236,1X06N@135613,COG1295@1,COG1295@2	NA|NA|NA	S	Virulence factor BrkB
MAG.T22.39_00965	1504319.GM45_0280	6.7e-79	300.4	unclassified Actinobacteria (class)	yhhQ			ko:K09125					ko00000				Bacteria	2IFDB@201174,3UX0S@52018,COG1738@1,COG1738@2	NA|NA|NA	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MAG.T22.39_00966	1194972.MVAC_12858	2.5e-172	611.7	Mycobacteriaceae	tgt		2.4.2.29	ko:K00773			R03789,R10209	RC00063	ko00000,ko01000,ko03016				Bacteria	234BK@1762,2GMWY@201174,COG0343@1,COG0343@2	NA|NA|NA	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MAG.T22.39_00967	1896.JOAU01000002_gene3804	2.2e-93	349.7	Actinobacteria	slpD												Bacteria	2GJYS@201174,COG0596@1,COG0596@2	NA|NA|NA	NU	Alpha beta hydrolase
MAG.T22.39_00968	1449069.JMLO01000001_gene2023	1.9e-58	233.0	Nocardiaceae													Bacteria	2GK8I@201174,4FVEY@85025,COG2047@1,COG2047@2	NA|NA|NA	S	PAC2 family
MAG.T22.39_00970	1306174.JODP01000021_gene193	1.6e-75	290.0	Actinobacteria				ko:K06946					ko00000				Bacteria	2IES1@201174,COG3596@1,COG3596@2,COG3597@1,COG3597@2	NA|NA|NA	D	Domain of unknown function (DUF697)
MAG.T22.39_00971	47716.JOFH01000031_gene7344	2.1e-36	159.1	Actinobacteria	MA20_36170			ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	2GP5E@201174,COG0741@1,COG0741@2,COG0791@1,COG0791@2	NA|NA|NA	M	PFAM NLP P60 protein
MAG.T22.39_00972	1463855.JOHV01000002_gene2400	1.1e-43	184.5	Actinobacteria	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576											Bacteria	2GJBA@201174,COG1376@1,COG1376@2	NA|NA|NA	L	ErfK YbiS YcfS YnhG family protein
MAG.T22.39_00973	593907.Celgi_0059	1.6e-21	109.0	Cellulomonadaceae													Bacteria	2HFZ1@201174,4F2X6@85016,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T22.39_00974	471852.Tcur_3675	0.0	1575.8	Streptosporangiales	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	Bacteria	2GIU6@201174,4EHHS@85012,COG0508@1,COG0508@2,COG0567@1,COG0567@2	NA|NA|NA	C	2-oxoglutarate dehydrogenase C-terminal
MAG.T22.39_00975	1123320.KB889737_gene5378	3.1e-23	113.6	Actinobacteria													Bacteria	2E460@1,2GQGS@201174,32Z20@2	NA|NA|NA		
MAG.T22.39_00976	1120950.KB892749_gene3298	7.2e-106	390.6	Propionibacteriales													Bacteria	2GMHR@201174,4DN65@85009,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T22.39_00977	1003195.SCAT_4108	3.4e-22	110.9	Actinobacteria													Bacteria	2IFS4@201174,COG0681@1,COG0681@2	NA|NA|NA	U	peptidase
MAG.T22.39_00978	1120950.KB892749_gene3304	1.4e-55	222.2	Propionibacteriales	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518					ko00000,ko01000				Bacteria	293MU@1,2IFCB@201174,2ZR3M@2,4DQX0@85009	NA|NA|NA	S	Nickel-containing superoxide dismutase
MAG.T22.39_00980	298654.FraEuI1c_0808	6.5e-38	164.5	Frankiales	sigB	GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03090					ko00000,ko03021				Bacteria	2GKSY@201174,4ES7X@85013,COG1191@1,COG1191@2	NA|NA|NA	K	RNA polymerase
MAG.T22.39_00982	1123320.KB889737_gene5367	1e-72	280.4	Actinobacteria													Bacteria	2GJ3K@201174,COG1597@1,COG1597@2	NA|NA|NA	I	Diacylglycerol kinase
MAG.T22.39_00983	1283283.ATXA01000002_gene2799	1.9e-37	161.4	Frankiales	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K18955					ko00000,ko03000				Bacteria	2DMIE@1,2IQCG@201174,32RSG@2,4ET35@85013	NA|NA|NA	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MAG.T22.39_00984	351607.Acel_0559	2.4e-81	309.7	Frankiales	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936		M00839			ko00000,ko00002,ko01000,ko01001,ko02022				Bacteria	2GKMP@201174,4ES2M@85013,COG3920@1,COG3920@2	NA|NA|NA	T	histidine kinase, dimerisation phosphoacceptor
MAG.T22.39_00985	414996.IL38_19370	2.5e-14	84.3	Actinopolysporales	yngHB		2.1.3.1,6.4.1.1	ko:K01958,ko:K02160,ko:K17490	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376	R00344,R00353,R00742	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000				Bacteria	2GQHZ@201174,409I7@622450,COG1038@1,COG1038@2	NA|NA|NA	C	Biotin-lipoyl like
MAG.T22.39_00986	196162.Noca_1704	3e-61	241.9	Propionibacteriales													Bacteria	2GKY8@201174,4DPFJ@85009,COG2135@1,COG2135@2	NA|NA|NA	S	Belongs to the SOS response-associated peptidase family
MAG.T22.39_00987	1206743.BAGM01000102_gene2599	2.1e-126	459.1	Nocardiaceae	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJKX@201174,4FU48@85025,COG0128@1,COG0128@2	NA|NA|NA	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MAG.T22.39_00988	1298880.AUEV01000001_gene5743	2.6e-90	339.0	Actinobacteria	rsgA		3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100		R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009				Bacteria	2GJ37@201174,COG1162@1,COG1162@2	NA|NA|NA	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MAG.T22.39_00990	1120950.KB892764_gene5641	1.8e-128	466.1	Propionibacteriales	msi031			ko:K02283					ko00000,ko02035,ko02044				Bacteria	2GKKJ@201174,4DN91@85009,COG4962@1,COG4962@2	NA|NA|NA	U	Type II/IV secretion system protein
MAG.T22.39_00991	469371.Tbis_2983	2e-62	246.1	Pseudonocardiales													Bacteria	2GM96@201174,4DYFE@85010,COG2267@1,COG2267@2	NA|NA|NA	I	PFAM alpha beta hydrolase fold
MAG.T22.39_00992	1386089.N865_11620	2.5e-38	166.0	Actinobacteria				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2ID14@201174,COG1277@1,COG1277@2	NA|NA|NA	CP	ABC-2 family transporter protein
MAG.T22.39_00993	479432.Sros_7394	3.3e-57	228.8	Streptosporangiales				ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2I2U6@201174,4EIH3@85012,COG4152@1,COG4152@2	NA|NA|NA	S	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T22.39_00994	1137269.AZWL01000010_gene5097	3.4e-51	208.4	Actinobacteria													Bacteria	2GVM5@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_00995	1380354.JIAN01000005_gene1305	2e-14	84.7	Cellulomonadaceae													Bacteria	2E3M2@1,2GQQW@201174,32YJA@2,4F1HW@85016	NA|NA|NA	S	Protein of unknown function (DUF3107)
MAG.T22.39_00996	996637.SGM_4420	9.4e-76	290.0	Actinobacteria		GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0071771	1.16.3.1,4.1.99.5	ko:K03594,ko:K14331	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	2I2E1@201174,COG1633@1,COG1633@2	NA|NA|NA	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like
MAG.T22.39_00997	1169154.KB897776_gene1940	2.7e-159	568.5	Actinobacteria	deaD		3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	2GIUR@201174,COG0513@1,COG0513@2	NA|NA|NA	L	Belongs to the DEAD box helicase family
MAG.T22.39_00998	479435.Kfla_5365	4.2e-64	251.5	Propionibacteriales	soj			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2GNEQ@201174,4DP45@85009,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T22.39_00999	196162.Noca_1263	1.3e-13	82.8	Actinobacteria				ko:K03413	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	2I5BG@201174,COG2197@1,COG2197@2	NA|NA|NA	T	Histidine kinase-like ATPase domain
MAG.T22.39_01000	710111.FraQA3DRAFT_5554	4e-62	245.0	Frankiales				ko:K07465					ko00000				Bacteria	2I94N@201174,4ETNH@85013,COG2887@1,COG2887@2	NA|NA|NA	L	PD-(D/E)XK nuclease superfamily
MAG.T22.39_01001	469371.Tbis_3001	8.1e-30	136.7	Pseudonocardiales	MA20_42070												Bacteria	2IQEU@201174,4E5VV@85010,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
MAG.T22.39_01002	67267.JNXT01000021_gene6735	5.7e-185	653.7	Actinobacteria													Bacteria	2GIX8@201174,COG1960@1,COG1960@2	NA|NA|NA	I	acyl-CoA dehydrogenase
MAG.T22.39_01003	1048339.KB913029_gene2897	1.6e-145	522.3	Frankiales	mcl1		4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63	ko:K01644,ko:K08691,ko:K14447,ko:K18292	ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934,R09292	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK5J@201174,4ESAE@85013,COG0697@1,COG0697@2,COG2301@1,COG2301@2	NA|NA|NA	G	Belongs to the HpcH HpaI aldolase family
MAG.T22.39_01004	350054.Mflv_3420	1.3e-54	220.7	Mycobacteriaceae	ybjJ												Bacteria	235BH@1762,2GRCY@201174,COG0738@1,COG0738@2	NA|NA|NA	G	Major facilitator superfamily
MAG.T22.39_01005	1504319.GM45_2000	8.3e-67	260.8	unclassified Actinobacteria (class)													Bacteria	2I198@201174,3UX7U@52018,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_01006	351607.Acel_1818	2.1e-110	406.0	Frankiales	mgtE												Bacteria	2GMMK@201174,4ERJN@85013,COG2239@1,COG2239@2	NA|NA|NA	P	CBS domain
MAG.T22.39_01007	1157632.AQWQ01000013_gene2626	4.3e-47	194.5	Actinobacteria													Bacteria	2GJRV@201174,COG4420@1,COG4420@2	NA|NA|NA	S	membrane
MAG.T22.39_01008	358823.DF19_27085	2.2e-130	472.2	Actinobacteria	mrp	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03593					ko00000,ko03029,ko03036				Bacteria	2GJUZ@201174,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MAG.T22.39_01009	298653.Franean1_0887	7.7e-10	70.1	Frankiales	tatB	GO:0008150,GO:0040007		ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2IR0U@201174,4ETJD@85013,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
MAG.T22.39_01010	1504319.GM45_3220	5.1e-85	321.6	unclassified Actinobacteria (class)	sprI		3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	2GJ96@201174,3UWP8@52018,COG0265@1,COG0265@2	NA|NA|NA	O	Trypsin
MAG.T22.39_01011	390989.JOEG01000019_gene5951	4.9e-50	204.5	Micromonosporales	safC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944											Bacteria	2GPEV@201174,4DCDE@85008,COG4122@1,COG4122@2	NA|NA|NA	S	O-methyltransferase
MAG.T22.39_01012	1304865.JAGF01000001_gene207	1.4e-17	94.7	Cellulomonadaceae													Bacteria	2E39N@1,2GQFF@201174,32Y97@2,4F1JY@85016	NA|NA|NA	S	Protein of unknown function (DUF3117)
MAG.T22.39_01013	591158.SSMG_00722	9.4e-34	150.2	Actinobacteria													Bacteria	2II8Y@201174,COG3427@1,COG3427@2	NA|NA|NA	E	oxidoreductase activity, acting on CH-OH group of donors
MAG.T22.39_01015	298655.KI912266_gene5329	1.2e-54	219.5	Frankiales	yceI												Bacteria	2GJUB@201174,4ESN7@85013,COG2353@1,COG2353@2	NA|NA|NA	S	Belongs to the UPF0312 family
MAG.T22.39_01016	1048339.KB913029_gene25	3.2e-118	431.8	Frankiales	dapE	GO:0008150,GO:0040007	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK09@201174,4ES00@85013,COG0624@1,COG0624@2	NA|NA|NA	E	Succinyl-diaminopimelate desuccinylase
MAG.T22.39_01017	469371.Tbis_2652	3e-101	375.2	Pseudonocardiales	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1201c	Bacteria	2GIZ9@201174,4DYHD@85010,COG2171@1,COG2171@2	NA|NA|NA	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
MAG.T22.39_01018	1193181.BN10_130013	1.5e-148	532.3	Intrasporangiaceae	gltA		2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ7E@201174,4FEQ1@85021,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T22.39_01019	471852.Tcur_2819	1.6e-268	931.8	Streptosporangiales	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32,4.1.1.49	ko:K01596,ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003,M00170	R00341,R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2638	Bacteria	2GJH3@201174,4EFQF@85012,COG1274@1,COG1274@2	NA|NA|NA	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
MAG.T22.39_01020	105422.BBPM01000018_gene2470	8.5e-23	113.2	Streptacidiphilus	wblB			ko:K18955					ko00000,ko03000				Bacteria	2CC1Y@1,2IQS5@201174,2NJ8E@228398,32S23@2	NA|NA|NA	K	Transcription factor WhiB
MAG.T22.39_01021	1120950.KB892709_gene4113	5.6e-38	163.7	Propionibacteriales			1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110				Bacteria	2IKP1@201174,4DRIP@85009,COG0526@1,COG0526@2	NA|NA|NA	CO	Belongs to the thioredoxin family
MAG.T22.39_01022	1122237.AUGQ01000001_gene1072	1.2e-23	115.5	Microbacteriaceae													Bacteria	2CAFG@1,2IQ98@201174,32RRB@2,4FPI5@85023	NA|NA|NA	S	Protein of unknown function (DUF3039)
MAG.T22.39_01024	426716.JOAJ01000012_gene6687	1.3e-16	93.2	Nocardiaceae													Bacteria	2H3AT@201174,4FZ1T@85025,COG3247@1,COG3247@2	NA|NA|NA	S	Short repeat of unknown function (DUF308)
MAG.T22.39_01025	1463820.JOGW01000007_gene2013	2.8e-53	215.3	Actinobacteria	sdrB		6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GMEA@201174,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_01026	1313172.YM304_16100	4.3e-54	219.5	Actinobacteria													Bacteria	2HZ7I@201174,COG3858@1,COG3858@2	NA|NA|NA	S	Glycosyl hydrolases family 18
MAG.T22.39_01027	1121946.AUAX01000005_gene5377	4.5e-233	813.9	Micromonosporales	csdA		2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GP7W@201174,4DAKS@85008,COG0520@1,COG0520@2	NA|NA|NA	E	Aminotransferase class-V
MAG.T22.39_01028	1123065.ATWL01000002_gene1467	7.5e-27	126.3	Actinobacteria	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087		ko:K06891					ko00000				Bacteria	2IQ3Z@201174,COG2127@1,COG2127@2	NA|NA|NA	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MAG.T22.39_01029	28444.JODQ01000011_gene3474	5.2e-27	127.9	Streptosporangiales													Bacteria	2E4AX@1,2GW4T@201174,32Z6K@2,4EJ1I@85012	NA|NA|NA	S	Domain of unknown function (DUF2017)
MAG.T22.39_01030	105420.BBPO01000056_gene3468	1.4e-61	242.3	Streptacidiphilus	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122		R11524	RC00064,RC00090	ko00000,ko00001,ko01000				Bacteria	2IFB5@201174,2NIAS@228398,COG1310@1,COG1310@2	NA|NA|NA	S	JAB/MPN domain
MAG.T22.39_01031	469371.Tbis_0937	3.9e-33	147.1	Pseudonocardiales	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122		R07459,R07461	RC00043	ko00000,ko00001,ko01000				Bacteria	2IQBT@201174,4E5BP@85010,COG1977@1,COG1977@2	NA|NA|NA	H	TIGRFAM MoaD family protein
MAG.T22.39_01032	269800.Tfu_2368	4.4e-148	530.8	Streptosporangiales	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47,6.1.1.16	ko:K01883,ko:K12339,ko:K21148	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859,R10610	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GIXE@201174,4EHYN@85012,COG0031@1,COG0031@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T22.39_01034	585531.HMPREF0063_11865	1.4e-102	379.4	Propionibacteriales	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100		R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011			iYO844.BSU28390	Bacteria	2GN4I@201174,4DP8J@85009,COG0796@1,COG0796@2	NA|NA|NA	M	Provides the (R)-glutamate required for cell wall biosynthesis
MAG.T22.39_01036	1123320.KB889670_gene3584	3.9e-67	261.5	Actinobacteria													Bacteria	2GK78@201174,COG1028@1,COG1028@2	NA|NA|NA	IQ	PFAM Short-chain dehydrogenase reductase SDR
MAG.T22.39_01037	1123023.JIAI01000007_gene1828	7.1e-51	207.6	Pseudonocardiales	rhmR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K13641,ko:K19333					ko00000,ko03000				Bacteria	2GM23@201174,4E3H7@85010,COG1414@1,COG1414@2	NA|NA|NA	K	Bacterial transcriptional regulator
MAG.T22.39_01038	1394178.AWOO02000018_gene6608	1.7e-63	248.8	Bacteria	pdxH			ko:K07005					ko00000				Bacteria	COG3467@1,COG3467@2	NA|NA|NA	T	pyridoxamine 5'-phosphate
MAG.T22.39_01039	1394178.AWOO02000018_gene6609	6.2e-83	314.7	Actinobacteria			3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000				Bacteria	2I8IJ@201174,COG0624@1,COG0624@2	NA|NA|NA	E	Acetylornithine deacetylase
MAG.T22.39_01040	1123023.JIAI01000007_gene1830	2.2e-54	219.5	Pseudonocardiales				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJDW@201174,4E17N@85010,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01041	1394178.AWOO02000018_gene6611	6e-81	308.1	Streptosporangiales				ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GKZB@201174,4EM65@85012,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T22.39_01042	414996.IL38_11415	1.5e-108	400.2	Actinopolysporales	rbsA1		3.6.3.17	ko:K10441	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJ3F@201174,409TI@622450,COG1129@1,COG1129@2	NA|NA|NA	G	ATPases associated with a variety of cellular activities
MAG.T22.39_01043	1123023.JIAI01000007_gene1833	2e-39	169.9	Pseudonocardiales													Bacteria	2GQDN@201174,4E2FV@85010,COG1172@1,COG1172@2	NA|NA|NA	G	PFAM Branched-chain amino acid transport system permease component
MAG.T22.39_01044	367299.JOEE01000003_gene2921	1.5e-73	283.5	Intrasporangiaceae	cad		4.1.1.18,4.1.1.19	ko:K01582,ko:K01583,ko:K01585	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000			iJN678.cad	Bacteria	2GJ31@201174,4FJ0J@85021,COG1982@1,COG1982@2	NA|NA|NA	E	Orn/Lys/Arg decarboxylase, C-terminal domain
MAG.T22.39_01045	529884.Rhola_00013260	4.2e-28	131.7	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HT82@201174,4FSEQ@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_01046	529884.Rhola_00013270	8e-15	89.0	Microbacteriaceae													Bacteria	2BFXJ@1,2HTFG@201174,329T7@2,4FT9Y@85023	NA|NA|NA		
MAG.T22.39_01047	1384065.JAGS01000001_gene1941	2.6e-07	64.7	Ruminococcaceae													Bacteria	1TS8J@1239,24A7I@186801,3WGX5@541000,COG3209@1,COG3209@2,COG5492@1,COG5492@2	NA|NA|NA	N	dockerin type I repeat-containing domain protein
MAG.T22.39_01049	1150864.MILUP08_43023	6.2e-55	220.7	Micromonosporales													Bacteria	2I2JZ@201174,4DCM7@85008,COG2227@1,COG2227@2	NA|NA|NA	H	Methyltransferase
MAG.T22.39_01051	1380356.JNIK01000011_gene1679	6.2e-29	133.7	Frankiales	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066		ko:K03282					ko00000,ko02000	1.A.22.1			Bacteria	2IQDN@201174,4ET97@85013,COG1970@1,COG1970@2	NA|NA|NA	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MAG.T22.39_01053	1380356.JNIK01000019_gene218	8.1e-127	460.7	Frankiales	dld		1.1.3.15	ko:K00104,ko:K08167	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	M00713,M00714	R00475	RC00042	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3			Bacteria	2GJ2T@201174,4ERQV@85013,COG0277@1,COG0277@2	NA|NA|NA	C	PFAM FAD linked oxidase domain protein
MAG.T22.39_01054	710696.Intca_2280	3.2e-101	375.2	Intrasporangiaceae				ko:K07090					ko00000				Bacteria	2I5VT@201174,4FF73@85021,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
MAG.T22.39_01055	1157640.AQWO01000013_gene1521	1.2e-61	243.4	Actinobacteria				ko:K03710					ko00000,ko03000				Bacteria	2GKMH@201174,COG2188@1,COG2188@2	NA|NA|NA	K	transcriptional
MAG.T22.39_01056	1223544.GSI01S_42_00280	1.6e-142	512.7	Gordoniaceae	fccB		1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	2GRTN@201174,4GDPP@85026,COG0446@1,COG0446@2	NA|NA|NA	S	Pyridine nucleotide-disulphide oxidoreductase
MAG.T22.39_01057	208439.AJAP_20455	5.6e-76	291.2	Pseudonocardiales													Bacteria	2BYH3@1,2GMTF@201174,2Z7SZ@2,4DZHX@85010	NA|NA|NA	S	3-methyladenine DNA glycosylase
MAG.T22.39_01058	247156.NFA_9110	3.7e-69	268.9	Nocardiaceae													Bacteria	2GNGH@201174,4FUEX@85025,COG3268@1,COG3268@2	NA|NA|NA	S	Saccharopine dehydrogenase NADP binding domain
MAG.T22.39_01059	1077974.GOEFS_042_00370	1e-124	453.8	Gordoniaceae	aptA		2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100		R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007				Bacteria	2GKF6@201174,4GBJC@85026,COG0161@1,COG0161@2	NA|NA|NA	H	Aminotransferase class-III
MAG.T22.39_01061	391593.RCCS2_11447	8.9e-14	83.2	Roseobacter	crcB			ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Bacteria	1MZNH@1224,2P3JI@2433,2UBUP@28211,COG0239@1,COG0239@2	NA|NA|NA	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAG.T22.39_01062	909613.UO65_4360	4.9e-10	70.9	Pseudonocardiales	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425		ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Bacteria	2IKWG@201174,4E5I3@85010,COG0239@1,COG0239@2	NA|NA|NA	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAG.T22.39_01063	66377.JOBH01000013_gene1774	2.8e-237	828.6	Actinobacteria	acyII		3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130		R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002				Bacteria	2GISQ@201174,COG2366@1,COG2366@2	NA|NA|NA	J	Penicillin amidase
MAG.T22.39_01064	1229203.KI301992_gene310	2.2e-25	122.5	unclassified Actinobacteria (class)	fthC		6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100		R02301	RC00183	ko00000,ko00001,ko01000				Bacteria	2IKWR@201174,3UWZ4@52018,COG0212@1,COG0212@2	NA|NA|NA	H	5-formyltetrahydrofolate cyclo-ligase family
MAG.T22.39_01065	1298880.AUEV01000015_gene204	9.1e-116	423.3	Actinobacteria	galU	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509	2.7.7.9,5.4.2.8	ko:K00963,ko:K01840	ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130	M00114,M00129,M00361,M00362,M00549	R00289,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_1571,iHN637.CLJU_RS02205,iIT341.HP0646	Bacteria	2I2EW@201174,COG1210@1,COG1210@2	NA|NA|NA	M	Utp--glucose-1-phosphate uridylyltransferase
MAG.T22.39_01066	1380346.JNIH01000014_gene759	3.7e-48	198.0	Actinobacteria	rimJ		2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Bacteria	2HAFI@201174,COG1670@1,COG1670@2	NA|NA|NA	J	N-acetyltransferase
MAG.T22.39_01067	1169154.KB897779_gene2719	5.7e-08	65.1	Actinobacteria													Bacteria	2ETNC@1,2GKI3@201174,33M63@2	NA|NA|NA		
MAG.T22.39_01069	1283299.AUKG01000001_gene2492	3.9e-138	498.0	Rubrobacteria	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100		R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000				Bacteria	2GJCA@201174,4CS1G@84995,COG2115@1,COG2115@2	NA|NA|NA	G	Xylose isomerase-like TIM barrel
MAG.T22.39_01070	1172180.KB911776_gene990	5e-23	115.2	Bacteria	JD73_05665		5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000				Bacteria	COG2017@1,COG2017@2	NA|NA|NA	G	converts alpha-aldose to the beta-anomer
MAG.T22.39_01071	105422.BBPM01000048_gene1667	9.7e-72	277.3	Streptacidiphilus													Bacteria	2GN2Z@201174,2NFB6@228398,COG0673@1,COG0673@2	NA|NA|NA	S	Oxidoreductase family, C-terminal alpha/beta domain
MAG.T22.39_01072	284031.JNXD01000013_gene1999	2.2e-141	509.2	Actinobacteria	pmt		2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100		R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003		GT39		Bacteria	2I2H1@201174,COG1928@1,COG1928@2	NA|NA|NA	O	PFAM glycosyl transferase family 39
MAG.T22.39_01073	1440053.JOEI01000007_gene2413	1.6e-88	332.8	Actinobacteria	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056					ko00000,ko01000,ko03009				Bacteria	2GJ9Q@201174,COG0313@1,COG0313@2	NA|NA|NA	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MAG.T22.39_01074	1504319.GM45_2970	1.8e-210	738.8	unclassified Actinobacteria (class)	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GK4S@201174,3UW6I@52018,COG0143@1,COG0143@2	NA|NA|NA	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAG.T22.39_01075	1288083.AUKR01000009_gene1907	1.8e-79	302.8	Actinobacteria	tatD			ko:K03424					ko00000,ko01000				Bacteria	2GMJJ@201174,COG0084@1,COG0084@2	NA|NA|NA	L	Hydrolase, TatD family
MAG.T22.39_01076	1122622.ATWJ01000012_gene1089	9.9e-91	340.1	Intrasporangiaceae	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528			R10716	RC00003,RC03257	ko00000,ko01000,ko03009				Bacteria	2GKBT@201174,4FE9S@85021,COG0030@1,COG0030@2	NA|NA|NA	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MAG.T22.39_01077	1048339.KB913029_gene524	1.9e-92	345.9	Frankiales	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29		iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	Bacteria	2GKXD@201174,4ESAI@85013,COG1947@1,COG1947@2	NA|NA|NA	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MAG.T22.39_01078	1121017.AUFG01000070_gene635	4e-41	174.5	Intrasporangiaceae	pecS												Bacteria	2GJ6W@201174,4FGMI@85021,COG1846@1,COG1846@2	NA|NA|NA	K	MarR family transcriptional regulator
MAG.T22.39_01079	749414.SBI_04353	5.1e-75	287.7	Actinobacteria	icaR												Bacteria	2GMBW@201174,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_01080	1123023.JIAI01000005_gene470	1.2e-100	373.2	Pseudonocardiales			1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212		R02222	RC00917	ko00000,ko00001,ko01000,ko01004				Bacteria	2GJJF@201174,4E1KH@85010,COG1398@1,COG1398@2	NA|NA|NA	I	PFAM Fatty acid desaturase
MAG.T22.39_01082	1048339.KB913029_gene518	1e-156	560.1	Frankiales	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528,ko:K16203	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000,ko01002	3.A.1.5.2		iJN678.glmU,iLJ478.TM1629	Bacteria	2GJS1@201174,4ERCR@85013,COG1207@1,COG1207@2	NA|NA|NA	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MAG.T22.39_01083	680646.RMDY18_15920	2.5e-19	101.7	Bacteria													Bacteria	28TQJ@1,2ZFXT@2	NA|NA|NA		
MAG.T22.39_01085	406817.XNC1_0125	1.7e-11	75.9	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
MAG.T22.39_01086	590998.Celf_0036	3.3e-23	117.1	Actinobacteria													Bacteria	2BIFQ@1,2IN70@201174,32CNA@2	NA|NA|NA		
MAG.T22.39_01088	351607.Acel_1728	2.1e-58	231.9	Frankiales	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03664					ko00000				Bacteria	2GJX1@201174,4ESH9@85013,COG0691@1,COG0691@2	NA|NA|NA	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MAG.T22.39_01089	931627.MycrhDRAFT_5440	3.5e-17	95.9	Mycobacteriaceae													Bacteria	23310@1762,2E1SP@1,2I88S@201174,32V34@2	NA|NA|NA	S	Domain of unknown function (DUF4436)
MAG.T22.39_01090	871963.Desdi_3399	4.5e-31	142.5	Peptococcaceae				ko:K21471,ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	1VAC5@1239,25E3G@186801,267BP@186807,COG0739@1,COG0739@2,COG3883@1,COG3883@2	NA|NA|NA	M	PFAM Peptidase family M23
MAG.T22.39_01091	1048339.KB913029_gene5048	6.1e-83	314.3	Frankiales	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	2GJMA@201174,4ESQ7@85013,COG2177@1,COG2177@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division
MAG.T22.39_01092	452652.KSE_28880	1.6e-99	369.0	Kitasatospora	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	2GJE1@201174,2M0C0@2063,COG2884@1,COG2884@2	NA|NA|NA	D	ATPases associated with a variety of cellular activities
MAG.T22.39_01093	909613.UO65_5374	9e-153	546.6	Pseudonocardiales	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02836					ko00000,ko03012				Bacteria	2GJ0F@201174,4DZMR@85010,COG1186@1,COG1186@2	NA|NA|NA	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MAG.T22.39_01097	593907.Celgi_2868	8e-172	610.1	Cellulomonadaceae	hpaIIM		2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036				Bacteria	2HY0D@201174,4F2AH@85016,COG0270@1,COG0270@2	NA|NA|NA	L	C-5 cytosine-specific DNA methylase
MAG.T22.39_01102	1115632.JAFW01000001_gene617	1.3e-97	364.0	Micrococcaceae													Bacteria	1W82G@1268,2GJVW@201174,COG1574@1,COG1574@2	NA|NA|NA	E	Amidohydrolase family
MAG.T22.39_01103	290340.AAur_2549	2e-150	539.3	Actinobacteria			3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Bacteria	2GJ8H@201174,COG3119@1,COG3119@2	NA|NA|NA	P	Pfam Sulfatase
MAG.T22.39_01104	1115632.JAFW01000001_gene616	7.5e-45	188.0	Actinobacteria				ko:K02051		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17			Bacteria	2HH8J@201174,COG0715@1,COG0715@2	NA|NA|NA	P	ABC-type nitrate sulfonate bicarbonate transport
MAG.T22.39_01105	1238186.AOCN01000022_gene2349	5.5e-40	171.4	Microbacteriaceae													Bacteria	2GP2J@201174,4FQ1J@85023,COG0600@1,COG0600@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01106	1115632.JAFW01000001_gene614	1.4e-54	219.9	Micrococcaceae													Bacteria	1W84M@1268,2GKKZ@201174,COG0600@1,COG0600@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01107	1238186.AOCN01000022_gene2351	1.2e-76	293.1	Microbacteriaceae			3.6.3.21,3.6.3.25	ko:K02028,ko:K02045,ko:K02049	ko00920,ko02010,map00920,map02010	M00185,M00188,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.3,3.A.1.6.1,3.A.1.6.3			Bacteria	2GM73@201174,4FNMH@85023,COG1116@1,COG1116@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T22.39_01109	649831.L083_1971	3.9e-52	211.8	Micromonosporales			5.5.1.19	ko:K22502	ko00906,map00906		R03824,R05341	RC01004	ko00000,ko00001,ko01000				Bacteria	2IIUJ@201174,4DB1B@85008,COG2324@1,COG2324@2	NA|NA|NA	S	Carotenoid biosynthesis protein
MAG.T22.39_01110	1120948.KB903224_gene357	1.1e-38	166.4	Pseudonocardiales		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944											Bacteria	2IFJT@201174,4E4TI@85010,COG3832@1,COG3832@2	NA|NA|NA	S	Polyketide cyclase / dehydrase and lipid transport
MAG.T22.39_01111	446471.Xcel_3344	9.1e-44	183.7	Promicromonosporaceae			1.20.4.1	ko:K03741,ko:K03892					ko00000,ko01000,ko03000				Bacteria	2IHR3@201174,4F4G0@85017,COG0394@1,COG0394@2,COG0640@1,COG0640@2	NA|NA|NA	T	Low molecular weight phosphatase family
MAG.T22.39_01112	35754.JNYJ01000029_gene9541	5.1e-56	224.6	Micromonosporales	glpF		1.20.4.1	ko:K02440,ko:K03741,ko:K06188					ko00000,ko01000,ko02000	1.A.8,1.A.8.1,1.A.8.2			Bacteria	2GMG4@201174,4DA0H@85008,COG0580@1,COG0580@2	NA|NA|NA	G	Belongs to the MIP aquaporin (TC 1.A.8) family
MAG.T22.39_01113	1121934.AUDX01000028_gene507	2.4e-50	204.9	Microbacteriaceae	arsC		1.20.4.1	ko:K03741					ko00000,ko01000				Bacteria	2IHR3@201174,4FNQ6@85023,COG0394@1,COG0394@2	NA|NA|NA	T	Low molecular weight phosphatase family
MAG.T22.39_01114	1463841.JOIR01000012_gene2070	1.1e-31	143.7	Actinobacteria	alkD												Bacteria	2GNQD@201174,COG4912@1,COG4912@2	NA|NA|NA	L	DNA alkylation repair
MAG.T22.39_01115	58123.JOFJ01000001_gene3119	1.1e-44	186.4	Streptosporangiales	ybaK_1												Bacteria	2IKUX@201174,4EJ6P@85012,COG2606@1,COG2606@2	NA|NA|NA	S	Aminoacyl-tRNA editing domain
MAG.T22.39_01116	479433.Caci_0741	2.5e-19	101.3	Actinobacteria	phhB		3.5.4.33,4.2.1.96	ko:K01724,ko:K11991	ko00790,map00790		R04734,R10223	RC00477,RC01208	ko00000,ko00001,ko01000,ko03016,ko04147				Bacteria	2IKXR@201174,COG2154@1,COG2154@2	NA|NA|NA	H	dehydratase
MAG.T22.39_01117	196162.Noca_1001	2.2e-124	452.6	Propionibacteriales				ko:K07576					ko00000				Bacteria	2HEXB@201174,4DQ4R@85009,COG1236@1,COG1236@2	NA|NA|NA	J	Beta-Casp domain
MAG.T22.39_01118	656024.FsymDg_3127	1.7e-21	109.0	Frankiales													Bacteria	2CGM3@1,2GP7H@201174,32S47@2,4ET5Q@85013	NA|NA|NA		
MAG.T22.39_01119	1380347.JNII01000008_gene4226	0.0	1224.2	Frankiales	dnaE2		2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ1P@201174,4ERJ2@85013,COG0587@1,COG0587@2	NA|NA|NA	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase
MAG.T22.39_01120	526225.Gobs_3277	3.1e-141	508.4	Frankiales	dinB		2.7.7.7	ko:K02346					ko00000,ko01000,ko03400				Bacteria	2GKBI@201174,4EREM@85013,COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAG.T22.39_01121	1348663.KCH_21690	2.3e-18	98.6	Kitasatospora													Bacteria	2E49S@1,2IHN1@201174,2M2XK@2063,32Z5G@2	NA|NA|NA	S	Protein of unknown function (DUF3040)
MAG.T22.39_01122	1828.JOKB01000058_gene804	3e-69	268.1	Nocardiaceae													Bacteria	2IGCQ@201174,4FYK2@85025,COG2030@1,COG2030@2	NA|NA|NA	I	MaoC like domain
MAG.T22.39_01123	1449068.JMLQ01000016_gene4287	1.9e-87	329.7	Actinobacteria													Bacteria	2GJE5@201174,COG1073@1,COG1073@2	NA|NA|NA	S	Secretory lipase
MAG.T22.39_01124	362242.MUL_4313	3e-09	68.9	Mycobacteriaceae													Bacteria	23ASY@1762,2EEE7@1,2IMP5@201174,33888@2	NA|NA|NA		
MAG.T22.39_01125	1380347.JNII01000005_gene2990	6.3e-25	120.9	Actinobacteria													Bacteria	2IN6K@201174,COG1714@1,COG1714@2	NA|NA|NA	S	RDD family
MAG.T22.39_01127	1380354.JIAN01000009_gene3842	6e-21	107.1	Cellulomonadaceae				ko:K00389					ko00000				Bacteria	2GQU9@201174,4F1I7@85016,COG2149@1,COG2149@2	NA|NA|NA	S	Domain of unknown function (DUF202)
MAG.T22.39_01128	479432.Sros_5818	5.2e-117	428.7	Streptosporangiales													Bacteria	2GK30@201174,4EH5T@85012,COG3973@1,COG3973@2	NA|NA|NA	L	DNA helicase
MAG.T22.39_01130	1906.SFRA_11245	1.3e-66	260.4	Actinobacteria	yerB												Bacteria	2GP8D@201174,COG1470@1,COG1470@2	NA|NA|NA	S	Protein of unknown function (DUF3048) C-terminal domain
MAG.T22.39_01131	1504319.GM45_1075	1.1e-50	206.1	unclassified Actinobacteria (class)	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K03925					ko00000				Bacteria	2IHUB@201174,3UWSJ@52018,COG2001@1,COG2001@2	NA|NA|NA	K	MraZ protein, putative antitoxin-like
MAG.T22.39_01133	479435.Kfla_2878	1.1e-101	376.7	Propionibacteriales	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438					ko00000,ko01000,ko03009				Bacteria	2GJGK@201174,4DPXU@85009,COG0275@1,COG0275@2	NA|NA|NA	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MAG.T22.39_01134	67267.JNXT01000062_gene7371	1.5e-12	80.1	Actinobacteria	ftsL			ko:K05589,ko:K12065					ko00000,ko02044,ko03036	3.A.7.11.1			Bacteria	2I3SE@201174,COG2919@1,COG2919@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MAG.T22.39_01135	1504319.GM45_1090	1.7e-145	523.1	unclassified Actinobacteria (class)	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01011,ko03036			iSSON_1240.SSON_0092	Bacteria	2GKHH@201174,3UWG5@52018,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin-binding Protein dimerisation domain
MAG.T22.39_01136	935866.JAER01000036_gene3431	7.7e-104	384.4	Propionibacteriales	murE		6.3.2.10,6.3.2.13	ko:K01928,ko:K15792	ko00300,ko00550,map00300,map00550		R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2GIS2@201174,4DN64@85009,COG0769@1,COG0769@2	NA|NA|NA	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MAG.T22.39_01137	33898.JRHJ01000050_gene8129	2.8e-111	409.1	Actinobacteria	murF		6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502		R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2GK0Y@201174,COG0770@1,COG0770@2	NA|NA|NA	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MAG.T22.39_01138	1504319.GM45_1105	3.3e-112	411.8	unclassified Actinobacteria (class)	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502		R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146		iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Bacteria	2GNEH@201174,3UWA7@52018,COG0472@1,COG0472@2	NA|NA|NA	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAG.T22.39_01139	1122138.AQUZ01000010_gene5215	5.8e-131	474.6	Propionibacteriales	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100		R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iNJ661.Rv2155c	Bacteria	2GJZA@201174,4DNTV@85009,COG0771@1,COG0771@2	NA|NA|NA	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAG.T22.39_01140	1048339.KB913029_gene4577	4.8e-99	368.2	Frankiales	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28		Bacteria	2GKXP@201174,4ES9A@85013,COG0772@1,COG0772@2	NA|NA|NA	D	Belongs to the SEDS family
MAG.T22.39_01141	1160718.SU9_23200	8e-98	364.0	Actinobacteria	murG		2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112		R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011		GT28	iLJ478.TM0232	Bacteria	2GJEM@201174,COG0707@1,COG0707@2	NA|NA|NA	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAG.T22.39_01142	351607.Acel_1011	2e-149	535.8	Frankiales	murC	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100		R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2I2E7@201174,4ERUC@85013,COG0773@1,COG0773@2	NA|NA|NA	M	Belongs to the MurCDEF family
MAG.T22.39_01143	196162.Noca_3061	7.6e-30	137.5	Propionibacteriales	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036				Bacteria	2H4A4@201174,4DRPK@85009,COG1589@1,COG1589@2	NA|NA|NA	D	Cell division protein FtsQ
MAG.T22.39_01144	680198.SCAB_68031	1.1e-153	549.7	Actinobacteria	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03531	ko04112,map04112				ko00000,ko00001,ko02048,ko03036,ko04812				Bacteria	2GJWC@201174,COG0206@1,COG0206@2	NA|NA|NA	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MAG.T22.39_01145	351607.Acel_1013	3.8e-35	155.2	Frankiales	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944		ko:K05810					ko00000,ko01000				Bacteria	2GN1M@201174,4ESKN@85013,COG1496@1,COG1496@2	NA|NA|NA	S	Belongs to the multicopper oxidase YfiH RL5 family
MAG.T22.39_01146	1343740.M271_35960	9.5e-55	220.3	Actinobacteria	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363		ko:K06997					ko00000				Bacteria	2GMRJ@201174,COG0325@1,COG0325@2	NA|NA|NA	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MAG.T22.39_01147	1122611.KB903978_gene3351	1.8e-37	162.5	Streptosporangiales	sepF	GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0051301,GO:0071840,GO:0090529		ko:K09772					ko00000,ko03036				Bacteria	2GNVH@201174,4EIJC@85012,COG1799@1,COG1799@2	NA|NA|NA	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MAG.T22.39_01148	1122622.ATWJ01000009_gene3282	5.7e-19	100.1	Intrasporangiaceae	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02221					ko00000,ko02044				Bacteria	2GQI1@201174,4FHVS@85021,COG0762@1,COG0762@2	NA|NA|NA	S	membrane
MAG.T22.39_01150	1048339.KB913029_gene4568	0.0	1403.7	Frankiales	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_0027,iPC815.YPO0475	Bacteria	2GK9M@201174,4ERW9@85013,COG0060@1,COG0060@2	NA|NA|NA	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MAG.T22.39_01151	1385521.N803_06645	3.1e-42	178.7	Intrasporangiaceae	dksA			ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	2GJBE@201174,4FGBX@85021,COG1734@1,COG1734@2	NA|NA|NA	T	DNA-binding protein
MAG.T22.39_01152	1206735.BAGG01000040_gene1896	1.3e-33	149.8	Nocardiaceae	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	2GKRX@201174,4G0PW@85025,COG0597@1,COG0597@2	NA|NA|NA	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MAG.T22.39_01153	1095767.CAHD01000219_gene700	2.2e-115	422.2	Cellulomonadaceae	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180					ko00000,ko01000,ko03009,ko03016			iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	Bacteria	2GIY1@201174,4F1PZ@85016,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
MAG.T22.39_01154	351607.Acel_1054	0.0	1641.3	Frankiales	dnaE		2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2	NA|NA|NA	L	DNA polymerase III alpha subunit
MAG.T22.39_01155	1048339.KB913029_gene3000	1.1e-49	203.0	Frankiales	gpo		1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918		R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000			iJN678.slr1171	Bacteria	2IFJH@201174,4ESWN@85013,COG0386@1,COG0386@2	NA|NA|NA	O	Belongs to the glutathione peroxidase family
MAG.T22.39_01156	1134445.AJJM01000195_gene3793	2.4e-07	62.4	Actinobacteria													Bacteria	2EGQJ@1,2IHWM@201174,33AGQ@2	NA|NA|NA		
MAG.T22.39_01157	1193181.BN10_560042	1.2e-35	156.4	Intrasporangiaceae	ybaK	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K03976					ko00000,ko01000,ko03016				Bacteria	2IHS8@201174,4FGM4@85021,COG2606@1,COG2606@2	NA|NA|NA	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MAG.T22.39_01158	1306174.JODP01000009_gene6621	9.1e-31	140.6	Actinobacteria	lonD		3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	2GNWA@201174,COG2802@1,COG2802@2	NA|NA|NA	S	Peptidase S16, lon domain protein
MAG.T22.39_01159	471852.Tcur_2897	3.4e-159	568.2	Streptosporangiales	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKKA@201174,4EHY2@85012,COG0141@1,COG0141@2	NA|NA|NA	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MAG.T22.39_01160	351607.Acel_1059	2.3e-117	429.1	Frankiales	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJ9W@201174,4ERD9@85013,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MAG.T22.39_01161	298655.KI912267_gene7203	6.1e-79	300.4	Frankiales	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19	ko:K00013,ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457	RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007			iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570	Bacteria	2GKMD@201174,4ESDH@85013,COG0131@1,COG0131@2	NA|NA|NA	E	Imidazoleglycerol-phosphate dehydratase
MAG.T22.39_01162	1095767.CAHD01000219_gene693	1.2e-75	289.7	Cellulomonadaceae	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIYS@201174,4F0G2@85016,COG0118@1,COG0118@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MAG.T22.39_01163	1043493.BBLU01000006_gene2186	3.3e-93	348.2	Actinobacteria	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ4V@201174,COG0106@1,COG0106@2	NA|NA|NA	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MAG.T22.39_01164	1380347.JNII01000008_gene4163	1.7e-97	362.5	Frankiales	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIRP@201174,4ES76@85013,COG0107@1,COG0107@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MAG.T22.39_01165	1122182.KB903833_gene5151	1e-33	149.4	Micromonosporales	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1606	Bacteria	2IKKU@201174,4DDD9@85008,COG0139@1,COG0139@2	NA|NA|NA	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MAG.T22.39_01166	1463934.JOCF01000018_gene3981	5.5e-164	584.3	Actinobacteria	trpE		4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKJT@201174,COG0147@1,COG0147@2	NA|NA|NA	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MAG.T22.39_01168	397278.JOJN01000010_gene2265	2.7e-10	70.9	Propionibacteriales													Bacteria	290XR@1,2HZG0@201174,31XZ9@2,4DSNF@85009	NA|NA|NA		
MAG.T22.39_01169	1304865.JAGF01000001_gene399	1.1e-76	293.1	Cellulomonadaceae													Bacteria	2GJE6@201174,4F0QK@85016,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T22.39_01170	1283283.ATXA01000026_gene3693	1.8e-89	336.7	Frankiales													Bacteria	2I53J@201174,4EU80@85013,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
MAG.T22.39_01171	1449069.JMLO01000004_gene3781	1.6e-14	85.9	Nocardiaceae													Bacteria	2E37T@1,2GQH5@201174,32Y7G@2,4G2HP@85025	NA|NA|NA	S	Protein of unknown function (DUF2752)
MAG.T22.39_01172	1137268.AZXF01000016_gene1094	2.5e-91	342.0	Streptosporangiales	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIVV@201174,4EG0T@85012,COG0134@1,COG0134@2	NA|NA|NA	E	Indole-3-glycerol phosphate synthase
MAG.T22.39_01173	743718.Isova_1461	5e-165	587.4	Promicromonosporaceae	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM7Z@201174,4F3VV@85017,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MAG.T22.39_01174	570268.ANBB01000003_gene441	2.4e-75	288.9	Streptosporangiales	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN6T@201174,4EFW7@85012,COG0159@1,COG0159@2	NA|NA|NA	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MAG.T22.39_01175	1504319.GM45_1285	1e-33	150.6	unclassified Actinobacteria (class)	pknE_1												Bacteria	2GKH8@201174,3UWV7@52018,COG1651@1,COG1651@2	NA|NA|NA	O	Thioredoxin
MAG.T22.39_01176	1907.SGLAU_09180	0.0	2205.3	Actinobacteria	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230		R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000				Bacteria	2GN09@201174,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2	NA|NA|NA	E	Glutamate synthase
MAG.T22.39_01177	1348663.KCH_20780	1.1e-201	709.5	Kitasatospora	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Bacteria	2GJ0A@201174,2M0E8@2063,COG0493@1,COG0493@2	NA|NA|NA	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
MAG.T22.39_01178	1048339.KB913029_gene4528	6.8e-169	600.5	Frankiales	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740	Bacteria	2GJY8@201174,4ERSJ@85013,COG0469@1,COG0469@2	NA|NA|NA	G	Belongs to the pyruvate kinase family
MAG.T22.39_01179	981369.JQMJ01000004_gene4131	4.1e-61	241.1	Streptacidiphilus	pyrR	GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000,ko03000			iHN637.CLJU_RS05275	Bacteria	2GJNP@201174,2NEN8@228398,COG2065@1,COG2065@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T22.39_01180	1463936.JOJI01000003_gene824	1.1e-124	453.0	Actinobacteria	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15490	Bacteria	2GKNA@201174,COG0540@1,COG0540@2	NA|NA|NA	F	Belongs to the ATCase OTCase family
MAG.T22.39_01181	1289387.AUKW01000006_gene3746	3.4e-167	594.7	Actinobacteria	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ0T@201174,COG0044@1,COG0044@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MAG.T22.39_01182	1380346.JNIH01000023_gene6436	6.1e-25	120.9	Actinobacteria													Bacteria	2GM9I@201174,COG0505@1,COG0505@2	NA|NA|NA	EF	Belongs to the CarA family
MAG.T22.39_01183	1306406.ASHX01000001_gene3737	5.9e-160	570.5	Actinobacteria	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955,ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040	Bacteria	2GKFA@201174,COG0505@1,COG0505@2	NA|NA|NA	F	Belongs to the CarA family
MAG.T22.39_01184	351607.Acel_1298	0.0	1658.7	Frankiales	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	Bacteria	2GK5N@201174,4ERGS@85013,COG0458@1,COG0458@2	NA|NA|NA	F	Belongs to the CarB family
MAG.T22.39_01185	351607.Acel_1297	5.2e-100	370.9	Frankiales	pyrK			ko:K02823	ko00240,ko01100,map00240,map01100				ko00000,ko00001				Bacteria	2HQ24@201174,4ESI4@85013,COG0543@1,COG0543@2	NA|NA|NA	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
MAG.T22.39_01186	1283283.ATXA01000002_gene2609	2.5e-107	395.6	Frankiales	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15540	Bacteria	2GKC6@201174,4ERIP@85013,COG0167@1,COG0167@2	NA|NA|NA	F	Catalyzes the conversion of dihydroorotate to orotate
MAG.T22.39_01187	1120936.KB907210_gene5777	1.7e-64	252.7	Streptosporangiales	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	Bacteria	2HPEA@201174,4EHE6@85012,COG0284@1,COG0284@2	NA|NA|NA	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MAG.T22.39_01188	1123488.ATUF01000004_gene1627	1.3e-09	69.3	Actinobacteria	mihF		2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2IKPU@201174,4D6B9@85005,COG0099@1,COG0099@2	NA|NA|NA	J	integration host factor
MAG.T22.39_01189	330084.JNYZ01000014_gene6253	1.7e-49	202.6	Pseudonocardiales	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Bacteria	2GK2M@201174,4E1VY@85010,COG0194@1,COG0194@2	NA|NA|NA	F	Essential for recycling GMP and indirectly, cGMP
MAG.T22.39_01190	1048339.KB913029_gene3986	1.7e-29	135.2	Frankiales	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2IQHU@201174,4ET5S@85013,COG1758@1,COG1758@2	NA|NA|NA	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MAG.T22.39_01191	1229203.KI301992_gene1018	6.2e-110	404.4	unclassified Actinobacteria (class)	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJGJ@201174,3UWCS@52018,COG0452@1,COG0452@2	NA|NA|NA	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MAG.T22.39_01193	1303692.SFUL_5466	3.6e-16	90.1	Actinobacteria	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904		ko:K02911	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	2GQP3@201174,COG0333@1,COG0333@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL32 family
MAG.T22.39_01195	1214101.BN159_2821	1.2e-70	273.1	Actinobacteria	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205				ko00000,ko00001,ko01000,ko03009,ko03019,ko03036				Bacteria	2GKER@201174,COG0571@1,COG0571@2	NA|NA|NA	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MAG.T22.39_01196	103733.JNYO01000019_gene2109	3.9e-95	354.8	Pseudonocardiales	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJNT@201174,4DXDQ@85010,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MAG.T22.39_01197	1120950.KB892741_gene2716	0.0	1150.2	Propionibacteriales	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03529,ko:K19171					ko00000,ko02048,ko03036				Bacteria	2GK93@201174,4DN2T@85009,COG1196@1,COG1196@2	NA|NA|NA	D	Required for chromosome condensation and partitioning
MAG.T22.39_01198	1003195.SCAT_4417	3.2e-127	461.8	Actinobacteria	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7			Bacteria	2GJQH@201174,COG0552@1,COG0552@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MAG.T22.39_01199	1380347.JNII01000007_gene732	6.8e-152	543.9	Frankiales	amt			ko:K03320					ko00000,ko02000	1.A.11		iNJ661.Rv2920c	Bacteria	2GIZK@201174,4ERCB@85013,COG0004@1,COG0004@2	NA|NA|NA	P	Ammonium Transporter
MAG.T22.39_01200	351607.Acel_1565	2e-42	178.3	Frankiales	glnB			ko:K04751	ko02020,map02020				ko00000,ko00001				Bacteria	2IKN1@201174,4ESRI@85013,COG0347@1,COG0347@2	NA|NA|NA	K	Belongs to the P(II) protein family
MAG.T22.39_01201	1463856.JOHY01000025_gene3865	1.2e-162	580.5	Actinobacteria	glnD		2.7.7.59	ko:K00990	ko02020,map02020				ko00000,ko00001,ko01000				Bacteria	2GMKT@201174,COG2844@1,COG2844@2	NA|NA|NA	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MAG.T22.39_01202	471852.Tcur_3424	7.6e-171	607.1	Streptosporangiales	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9			Bacteria	2GK4R@201174,4EI0G@85012,COG0541@1,COG0541@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MAG.T22.39_01203	1035195.HMPREF9997_01527	8.7e-43	180.3	Corynebacteriaceae	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02959	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	22MXN@1653,2IKU0@201174,COG0228@1,COG0228@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bS16 family
MAG.T22.39_01204	479431.Namu_3135	1.5e-20	105.1	Frankiales	CP_0960	GO:0008150,GO:0040007		ko:K06960					ko00000				Bacteria	2IQ4C@201174,4ETC9@85013,COG1837@1,COG1837@2	NA|NA|NA	S	Belongs to the UPF0109 family
MAG.T22.39_01205	436229.JOEH01000033_gene3585	1.7e-42	179.1	Streptacidiphilus	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360		ko:K02860					ko00000,ko03009				Bacteria	2GK4I@201174,2NEBS@228398,COG0806@1,COG0806@2	NA|NA|NA	J	RimM N-terminal domain
MAG.T22.39_01206	471852.Tcur_3420	5.6e-68	264.2	Streptosporangiales	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	2GJ1G@201174,4EGB1@85012,COG0336@1,COG0336@2	NA|NA|NA	J	Belongs to the RNA methyltransferase TrmD family
MAG.T22.39_01207	351607.Acel_1557	3.1e-46	191.0	Frankiales	rplS	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02884	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHRT@201174,4ESVQ@85013,COG0335@1,COG0335@2	NA|NA|NA	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MAG.T22.39_01208	1123320.KB889676_gene2845	2.4e-68	265.4	Actinobacteria			3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	2GIYN@201174,COG0681@1,COG0681@2	NA|NA|NA	U	Belongs to the peptidase S26 family
MAG.T22.39_01209	1504319.GM45_4440	2.3e-48	199.1	unclassified Actinobacteria (class)	lepB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	2GIYN@201174,3UWRN@52018,COG0681@1,COG0681@2	NA|NA|NA	U	Belongs to the peptidase S26 family
MAG.T22.39_01210	1463887.KL589975_gene5397	1e-36	160.2	Actinobacteria	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	2GJFN@201174,COG0164@1,COG0164@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MAG.T22.39_01211	479435.Kfla_4750	4.2e-27	127.5	Propionibacteriales	yraN			ko:K07460					ko00000				Bacteria	2IQ3X@201174,4DRQN@85009,COG0792@1,COG0792@2	NA|NA|NA	L	Belongs to the UPF0102 family
MAG.T22.39_01212	526225.Gobs_3997	1.4e-100	373.6	Frankiales				ko:K07391					ko00000				Bacteria	2GJIQ@201174,4ERBP@85013,COG0606@1,COG0606@2	NA|NA|NA	O	PFAM Magnesium chelatase, ChlI subunit
MAG.T22.39_01213	1120950.KB892769_gene5380	2.2e-58	233.0	Propionibacteriales	dprA		5.99.1.2	ko:K03168,ko:K04096					ko00000,ko01000,ko03032,ko03400				Bacteria	2GKDA@201174,4DPDI@85009,COG0758@1,COG0758@2	NA|NA|NA	LU	DNA recombination-mediator protein A
MAG.T22.39_01214	1323361.JPOC01000056_gene1255	2.6e-24	118.6	Nocardiaceae													Bacteria	2IQ64@201174,4G1TW@85025,COG0739@1,COG0739@2	NA|NA|NA	M	Peptidase family M23
MAG.T22.39_01215	1169161.KB897714_gene6235	4.6e-122	444.1	Actinobacteria	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GMYC@201174,COG0052@1,COG0052@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS2 family
MAG.T22.39_01216	196162.Noca_2439	1.1e-75	289.7	Propionibacteriales	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ4U@201174,4DN34@85009,COG0192@1,COG0192@2	NA|NA|NA	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MAG.T22.39_01217	1048339.KB913029_gene3997	3.6e-125	455.7	Frankiales	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576		ko:K04066	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKES@201174,4ERHY@85013,COG1198@1,COG1198@2	NA|NA|NA	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MAG.T22.39_01218	1172188.KB911823_gene318	1e-72	279.6	Intrasporangiaceae	def		3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	2GJ87@201174,4FG5A@85021,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MAG.T22.39_01219	1464048.JNZS01000019_gene2320	7e-82	310.8	Micromonosporales	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.1.176,2.1.2.9	ko:K00604,ko:K03500	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000,ko03009			iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Bacteria	2GKH5@201174,4DB7W@85008,COG0223@1,COG0223@2	NA|NA|NA	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAG.T22.39_01220	644283.Micau_2350	4.5e-101	375.2	Micromonosporales	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500					ko00000,ko01000,ko03009				Bacteria	2GM21@201174,4D9W7@85008,COG0144@1,COG0144@2,COG0781@1,COG0781@2	NA|NA|NA	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
MAG.T22.39_01221	1298863.AUEP01000012_gene3748	6.7e-64	250.8	Propionibacteriales	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZ9@201174,4DNZI@85009,COG0036@1,COG0036@2	NA|NA|NA	G	Belongs to the ribulose-phosphate 3-epimerase family
MAG.T22.39_01222	110319.CF8_2277	6.9e-75	287.7	Propionibacteriales	ribD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193,3.5.4.26	ko:K01498,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1624,iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iLJ478.TM1828,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524	Bacteria	2GKAX@201174,4DNKD@85009,COG0117@1,COG0117@2,COG1985@1,COG1985@2	NA|NA|NA	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MAG.T22.39_01223	196164.23493555	2e-61	242.3	Corynebacteriaceae	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9,3.5.4.25,4.1.99.12	ko:K00793,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00066,R00425,R07281	RC00293,RC00958,RC00960,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS08950	Bacteria	22M8W@1653,2GKC5@201174,COG0307@1,COG0307@2	NA|NA|NA	H	Riboflavin synthase
MAG.T22.39_01224	1120948.KB903240_gene3922	1.3e-158	566.2	Pseudonocardiales	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1415	Bacteria	2GIWJ@201174,4DXCJ@85010,COG0108@1,COG0108@2,COG0807@1,COG0807@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAG.T22.39_01225	1123013.AUIC01000003_gene721	5.7e-48	197.2	Microbacteriaceae	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000				Bacteria	2II1Z@201174,4FNJZ@85023,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MAG.T22.39_01226	196162.Noca_2451	1.7e-25	121.7	Propionibacteriales	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	Bacteria	2IQ4D@201174,4DRHZ@85009,COG0140@1,COG0140@2	NA|NA|NA	E	phosphoribosyl-ATP diphosphatase activity
MAG.T22.39_01227	446468.Ndas_5380	1e-95	356.7	Streptosporangiales	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNAX@201174,4EGFE@85012,COG0040@1,COG0040@2	NA|NA|NA	E	ATP phosphoribosyltransferase
MAG.T22.39_01228	935866.JAER01000002_gene2040	2.3e-19	102.1	Propionibacteriales				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GMN0@201174,4DRFX@85009,COG1404@1,COG1404@2	NA|NA|NA	O	SseB protein N-terminal domain
MAG.T22.39_01229	1029824.AFID01000009_gene2347	1.8e-30	138.7	Micrococcaceae													Bacteria	1W9FH@1268,2AI3Y@1,2IHSQ@201174,318HW@2	NA|NA|NA		
MAG.T22.39_01230	479435.Kfla_5455	2.5e-77	295.0	Propionibacteriales	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Bacteria	2GJGT@201174,4DNG8@85009,COG0290@1,COG0290@2	NA|NA|NA	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MAG.T22.39_01231	266940.Krad_3168	1.7e-19	101.3	Actinobacteria	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02916	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQZW@201174,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
MAG.T22.39_01232	1306406.ASHX01000001_gene215	1.2e-193	682.6	Actinobacteria	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03466					ko00000,ko03036	3.A.12			Bacteria	2GK3T@201174,COG1674@1,COG1674@2	NA|NA|NA	D	Belongs to the FtsK SpoIIIE SftA family
MAG.T22.39_01233	1122182.KB903839_gene1111	5.5e-147	527.7	Micromonosporales	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441			R10652	RC00003,RC03217	ko00000,ko01000,ko03009				Bacteria	2GKRI@201174,4DAWC@85008,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
MAG.T22.39_01234	1380354.JIAN01000007_gene115	1.3e-41	176.4	Cellulomonadaceae	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	2GK5D@201174,4F18H@85016,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T22.39_01235	1043493.BBLU01000006_gene2123	1.3e-26	126.3	Actinobacteria	cinA		3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	2IQ8T@201174,COG1546@1,COG1546@2	NA|NA|NA	I	Belongs to the CinA family
MAG.T22.39_01236	1121926.AXWO01000016_gene4142	1.4e-19	102.1	Glycomycetales	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	2GR3F@201174,4EYYA@85014,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_01237	645465.ACUR01000268_gene107	3.8e-24	118.6	Actinobacteria													Bacteria	2E96W@1,2IE1Q@201174,333FE@2	NA|NA|NA	S	Sulfotransferase family
MAG.T22.39_01238	1504319.GM45_4785	1.5e-97	363.2	unclassified Actinobacteria (class)													Bacteria	2GIR8@201174,3UWG4@52018,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T22.39_01239	1123065.ATWL01000021_gene3680	4.9e-220	770.4	Actinobacteria	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147			iSBO_1134.SBO_3210,iSbBS512_1146.SbBS512_E3599	Bacteria	2GK96@201174,COG0137@1,COG0137@2	NA|NA|NA	E	Belongs to the argininosuccinate synthase family. Type
MAG.T22.39_01240	446469.Sked_23200	2.3e-158	565.1	Actinobacteria	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Bacteria	2GJ4P@201174,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MAG.T22.39_01241	1121272.KB903272_gene431	1.6e-24	119.4	Micromonosporales	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03565					ko00000,ko03400				Bacteria	2GMRF@201174,4DD5X@85008,COG2137@1,COG2137@2	NA|NA|NA	S	Modulates RecA activity
MAG.T22.39_01242	543632.JOJL01000008_gene5597	3.5e-130	472.6	Micromonosporales				ko:K06994					ko00000				Bacteria	2GJ5A@201174,4DB3M@85008,COG2409@1,COG2409@2	NA|NA|NA	S	MMPL family
MAG.T22.39_01243	471852.Tcur_3285	1.1e-195	689.5	Streptosporangiales	miaB		2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Bacteria	2GJEV@201174,4EFYX@85012,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAG.T22.39_01244	469371.Tbis_1130	3.5e-81	308.5	Pseudonocardiales	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110		R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016				Bacteria	2GKFT@201174,4DX5R@85010,COG0324@1,COG0324@2	NA|NA|NA	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MAG.T22.39_01245	1206729.BAFZ01000162_gene5537	8.4e-52	210.7	Nocardiaceae													Bacteria	2GIUS@201174,4FY27@85025,COG2120@1,COG2120@2	NA|NA|NA	S	GlcNAc-PI de-N-acetylase
MAG.T22.39_01246	471853.Bcav_3037	3.8e-66	258.8	Bacteria			2.4.1.345	ko:K08256			R11702		ko00000,ko01000,ko01003		GT4		Bacteria	COG0297@1,COG0297@2,COG0438@1,COG0438@2	NA|NA|NA	G	glycogen (starch) synthase activity
MAG.T22.39_01247	1137269.AZWL01000004_gene2046	1e-60	240.4	Actinobacteria	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000			iIT341.HP0566,iLJ478.TM1522	Bacteria	2GKUD@201174,COG0253@1,COG0253@2	NA|NA|NA	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MAG.T22.39_01248	981369.JQMJ01000004_gene5503	7.2e-163	580.5	Streptacidiphilus	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464		ko:K03665					ko00000,ko03009				Bacteria	2GK55@201174,2NEXG@228398,COG2262@1,COG2262@2	NA|NA|NA	S	GTP-binding GTPase Middle Region
MAG.T22.39_01249	358823.DF19_11445	1.7e-151	543.1	Actinobacteria	dinG	GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GKT8@201174,COG1199@1,COG1199@2	NA|NA|NA	KL	helicase
MAG.T22.39_01250	1120950.KB892707_gene4592	1.5e-76	292.7	Propionibacteriales	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	2GMBN@201174,4DNCQ@85009,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MAG.T22.39_01251	1121952.ATXT01000018_gene1789	3.1e-09	68.2	Microbacteriaceae													Bacteria	2GWI9@201174,4FQ73@85023,COG1388@1,COG1388@2	NA|NA|NA	M	Lysin motif
MAG.T22.39_01252	1356854.N007_04550	7.9e-09	67.8	Alicyclobacillaceae													Bacteria	1TPTG@1239,278XK@186823,4HB7R@91061,COG1835@1,COG1835@2	NA|NA|NA	I	Acyltransferase family
MAG.T22.39_01253	1120950.KB892707_gene4594	2.7e-56	224.9	Propionibacteriales	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07738					ko00000,ko03000				Bacteria	2IHU9@201174,4DQJU@85009,COG1327@1,COG1327@2	NA|NA|NA	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MAG.T22.39_01254	526225.Gobs_3898	0.0	1455.7	Frankiales	nrdJ		1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2GKX9@201174,4ERKQ@85013,COG0209@1,COG0209@2	NA|NA|NA	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
MAG.T22.39_01255	1463887.KL590004_gene1879	5.4e-18	97.4	Actinobacteria													Bacteria	2B073@1,2GQSR@201174,31SHV@2	NA|NA|NA		
MAG.T22.39_01256	113395.AXAI01000003_gene5831	4.7e-14	85.1	Bradyrhizobiaceae													Bacteria	1MVVV@1224,2TSWB@28211,3JR57@41294,COG3971@1,COG3971@2	NA|NA|NA	Q	2-keto-4-pentenoate hydratase
MAG.T22.39_01258	1274.HX89_06000	2.8e-231	807.7	Dermacoccaceae	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Bacteria	1ZVMB@145357,2GMN1@201174,COG0174@1,COG0174@2	NA|NA|NA	E	glutamine synthetase
MAG.T22.39_01259	180281.CPCC7001_2187	9.8e-13	80.1	Cyanobium	ste14												Bacteria	1G6UG@1117,22SRB@167375,COG2020@1,COG2020@2	NA|NA|NA	O	Phospholipid methyltransferase
MAG.T22.39_01260	479432.Sros_2618	7.9e-292	1010.0	Streptosporangiales	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982					ko00000,ko01000				Bacteria	2GJ91@201174,4EFGN@85012,COG1391@1,COG1391@2	NA|NA|NA	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
MAG.T22.39_01261	85643.Tmz1t_3085	9.1e-45	186.0	Rhodocyclales				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1MVYI@1224,2KZYM@206389,2VHGT@28216,COG0410@1,COG0410@2	NA|NA|NA	E	ABC transporter
MAG.T22.39_01264	1122933.JNIY01000003_gene727	2e-58	233.4	Cellulomonadaceae				ko:K03281					ko00000	2.A.49			Bacteria	2GJHP@201174,4F2KU@85016,COG0038@1,COG0038@2	NA|NA|NA	P	Voltage gated chloride channel
MAG.T22.39_01265	479433.Caci_7900	4.5e-14	85.1	Actinobacteria													Bacteria	2GRE3@201174,COG3548@1,COG3548@2	NA|NA|NA	S	Protein of unknown function (DUF1211)
MAG.T22.39_01266	1123065.ATWL01000022_gene3708	1.9e-255	888.3	Actinobacteria	ercc3		3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290			ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2GIR9@201174,COG1061@1,COG1061@2	NA|NA|NA	L	helicase
MAG.T22.39_01267	1504319.GM45_2815	2.3e-84	319.3	Actinobacteria	MA20_32325		3.4.17.11	ko:K01295					ko00000,ko01000,ko01002				Bacteria	2GMH2@201174,COG0624@1,COG0624@2	NA|NA|NA	E	peptidase
MAG.T22.39_01268	479435.Kfla_4918	2.5e-41	176.0	Propionibacteriales													Bacteria	2I8MV@201174,4DTUP@85009,COG3375@1,COG3375@2	NA|NA|NA	M	Mandelate Racemase Muconate Lactonizing
MAG.T22.39_01269	345341.KUTG_02812	5.7e-115	421.0	Pseudonocardiales	menC	GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJJR@201174,4E02U@85010,COG4948@1,COG4948@2	NA|NA|NA	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MAG.T22.39_01270	1283287.KB822575_gene179	2.4e-43	183.7	Propionibacteriales	M1-1077												Bacteria	2GURQ@201174,4DP0U@85009,COG2378@1,COG2378@2	NA|NA|NA	K	Helicase conserved C-terminal domain
MAG.T22.39_01272	1304865.JAGF01000001_gene589	6.6e-44	183.7	Cellulomonadaceae	cspB			ko:K03704					ko00000,ko03000				Bacteria	2IKXN@201174,4F1ED@85016,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock protein domain
MAG.T22.39_01273	1463820.JOGW01000009_gene724	3.2e-11	75.1	Actinobacteria													Bacteria	2F261@1,2IFIE@201174,33V4D@2	NA|NA|NA		
MAG.T22.39_01274	452652.KSE_44370	3.8e-60	238.4	Kitasatospora													Bacteria	28NWB@1,2GJ74@201174,2M0SW@2063,2ZBU7@2	NA|NA|NA	S	Protein of unknown function (DUF3027)
MAG.T22.39_01276	1122138.AQUZ01000055_gene6244	1.9e-158	565.8	Propionibacteriales	yjcD	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40			Bacteria	2GKYD@201174,4DNIA@85009,COG2252@1,COG2252@2	NA|NA|NA	S	Permease family
MAG.T22.39_01277	351607.Acel_0113	2.7e-54	219.5	Frankiales													Bacteria	2IBR1@201174,4ESXS@85013,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T22.39_01278	644283.Micau_0514	2.7e-149	535.0	Micromonosporales	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKYK@201174,4D8WE@85008,COG1932@1,COG1932@2	NA|NA|NA	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MAG.T22.39_01279	67257.JODR01000013_gene6230	3.1e-177	627.9	Actinobacteria	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GKST@201174,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
MAG.T22.39_01280	1123322.KB904675_gene3055	5.4e-60	237.7	Actinobacteria	pdxH		1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJCR@201174,COG0259@1,COG0259@2	NA|NA|NA	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
MAG.T22.39_01281	67352.JODS01000021_gene3805	1.1e-105	390.2	Actinobacteria				ko:K08225					ko00000,ko02000	2.A.1.38			Bacteria	2GKFJ@201174,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator superfamily
MAG.T22.39_01283	414996.IL38_08930	2.5e-51	209.1	Actinopolysporales	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2H4UC@201174,40812@622450,COG1192@1,COG1192@2	NA|NA|NA	D	AAA domain
MAG.T22.39_01284	1048339.KB913029_gene2169	1.9e-144	519.2	Frankiales	phrB	GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0018298,GO:0019222,GO:0019538,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379	4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Bacteria	2GJXU@201174,4ERIM@85013,COG0415@1,COG0415@2	NA|NA|NA	L	DNA photolyase
MAG.T22.39_01285	1123320.KB889746_gene8007	2.8e-72	278.5	Actinobacteria	ideR			ko:K03709					ko00000,ko03000				Bacteria	2GKMC@201174,COG1321@1,COG1321@2	NA|NA|NA	K	iron dependent repressor
MAG.T22.39_01286	1463825.JNXC01000011_gene279	5.6e-143	514.2	Pseudonocardiales			2.1.1.79	ko:K00574					ko00000,ko01000				Bacteria	2GJ94@201174,4DXZT@85010,COG2230@1,COG2230@2	NA|NA|NA	M	Cyclopropane-fatty-acyl-phospholipid synthase
MAG.T22.39_01287	471852.Tcur_1573	3.8e-156	558.1	Streptosporangiales			1.3.1.72	ko:K09828	ko00100,ko01100,ko01110,map00100,map01100,map01110	M00101	R01457,R03689,R05703,R07488,R07493,R07498,R07499,R07507,R11096	RC00522,RC01887,RC02419	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKQR@201174,4EFTT@85012,COG0277@1,COG0277@2	NA|NA|NA	C	FAD binding domain
MAG.T22.39_01289	1504319.GM45_0620	3.7e-170	605.5	unclassified Actinobacteria (class)				ko:K06994					ko00000				Bacteria	2GIRQ@201174,3UX4Q@52018,COG2409@1,COG2409@2	NA|NA|NA	S	MMPL family
MAG.T22.39_01290	561175.KB894096_gene388	2e-73	283.5	Streptosporangiales				ko:K03316					ko00000	2.A.36			Bacteria	2GIUT@201174,4EHJF@85012,COG0025@1,COG0025@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T22.39_01291	1122247.C731_4754	3.7e-56	224.6	Mycobacteriaceae													Bacteria	233TV@1762,2AXA6@1,2GNHB@201174,31P99@2	NA|NA|NA		
MAG.T22.39_01292	471852.Tcur_0033	8.8e-103	380.2	Streptosporangiales	ydbC		1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120		R01708	RC00116	ko00000,ko00001,ko01000				Bacteria	2GJ6R@201174,4EICB@85012,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo/keto reductase family
MAG.T22.39_01293	395492.Rleg2_4431	3.2e-108	398.7	Rhizobiaceae													Bacteria	1N0ID@1224,2TT7V@28211,4BCE1@82115,COG2124@1,COG2124@2	NA|NA|NA	Q	Cytochrome P450
MAG.T22.39_01295	406124.ACPC01000046_gene2352	3.2e-145	522.3	Bacillus			3.1.6.6	ko:K01133					ko00000,ko01000				Bacteria	1UDRD@1239,1ZCSX@1386,4HD9J@91061,COG3119@1,COG3119@2	NA|NA|NA	P	Protein of unknown function (DUF229)
MAG.T22.39_01296	367299.JOEE01000003_gene2921	2.7e-93	349.4	Intrasporangiaceae	cad		4.1.1.18,4.1.1.19	ko:K01582,ko:K01583,ko:K01585	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000			iJN678.cad	Bacteria	2GJ31@201174,4FJ0J@85021,COG1982@1,COG1982@2	NA|NA|NA	E	Orn/Lys/Arg decarboxylase, C-terminal domain
MAG.T22.39_01297	1304865.JAGF01000001_gene3360	2e-12	78.6	Actinobacteria													Bacteria	2GS68@201174,COG0695@1,COG0695@2	NA|NA|NA	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MAG.T22.39_01298	196162.Noca_3784	9.2e-114	416.8	Propionibacteriales													Bacteria	2GMXW@201174,4DTAU@85009,COG0785@1,COG0785@2	NA|NA|NA	O	Cytochrome C biogenesis protein transmembrane region
MAG.T22.39_01299	1122609.AUGT01000027_gene2724	2.8e-58	231.9	Actinobacteria			1.11.1.15	ko:K03386,ko:K03564,ko:K16922	ko04214,map04214				ko00000,ko00001,ko01000,ko01002,ko04147				Bacteria	2IGFI@201174,COG1225@1,COG1225@2	NA|NA|NA	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAG.T22.39_01301	1122622.ATWJ01000005_gene3406	7.7e-140	503.8	Intrasporangiaceae	MA20_27390												Bacteria	2GVNB@201174,4FEHK@85021,COG2271@1,COG2271@2	NA|NA|NA	G	Major Facilitator Superfamily
MAG.T22.39_01302	1123247.AUIJ01000007_gene2812	7.3e-40	170.6	Alphaproteobacteria			2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000				Bacteria	1QWJU@1224,2TWZZ@28211,COG4106@1,COG4106@2	NA|NA|NA	S	Methyltransferase domain
MAG.T22.39_01303	1169154.KB897778_gene3112	3.7e-103	382.5	Actinobacteria				ko:K03294,ko:K03758					ko00000,ko02000	2.A.3.2			Bacteria	2GMTD@201174,COG0531@1,COG0531@2	NA|NA|NA	E	amino acid
MAG.T22.39_01304	247156.NFA_52230	2.3e-16	93.2	Nocardiaceae	pknE_1												Bacteria	2GKH8@201174,4FWD9@85025,COG1651@1,COG1651@2	NA|NA|NA	O	Thioredoxin
MAG.T22.39_01305	446471.Xcel_0209	1.6e-93	349.7	Promicromonosporaceae													Bacteria	2GN4Y@201174,4F4RK@85017,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T22.39_01306	1380356.JNIK01000021_gene4538	3.2e-61	241.9	Actinobacteria	glpF			ko:K02440,ko:K06188					ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2			Bacteria	2GKK3@201174,COG0580@1,COG0580@2	NA|NA|NA	G	Belongs to the MIP aquaporin (TC 1.A.8) family
MAG.T22.39_01308	96561.Dole_2293	6.8e-35	154.5	Desulfobacterales	budA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660		R02948	RC00812	ko00000,ko00001,ko01000				Bacteria	1MWDZ@1224,2MJJP@213118,2WN1P@28221,42R9C@68525,COG3527@1,COG3527@2	NA|NA|NA	Q	PFAM alpha-acetolactate decarboxylase
MAG.T22.39_01309	43354.JOIJ01000035_gene3159	8.9e-32	143.3	Pseudonocardiales													Bacteria	2IMJX@201174,4E4VY@85010,COG2050@1,COG2050@2	NA|NA|NA	Q	Thioesterase superfamily
MAG.T22.39_01311	1380347.JNII01000005_gene3235	5.4e-29	134.0	Frankiales													Bacteria	2IQJ3@201174,4EVSW@85013,COG4828@1,COG4828@2	NA|NA|NA	S	Protein of unknown function (DUF1622)
MAG.T22.39_01312	1385518.N798_10720	1.5e-111	409.1	Intrasporangiaceae	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GKRN@201174,4FFH3@85021,COG2326@1,COG2326@2	NA|NA|NA	S	Polyphosphate kinase 2 (PPK2)
MAG.T22.39_01313	1035308.AQYY01000001_gene2114	3e-48	198.0	Clostridia		GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko01000,ko03110				Bacteria	1VA3Y@1239,24MM5@186801,COG3118@1,COG3118@2	NA|NA|NA	O	Belongs to the thioredoxin family
MAG.T22.39_01314	1306174.JODP01000002_gene5868	2.7e-58	232.3	Actinobacteria													Bacteria	2GNBP@201174,COG2755@1,COG2755@2	NA|NA|NA	E	G-D-S-L family
MAG.T22.39_01315	66429.JOFL01000016_gene245	2.1e-21	109.4	Actinobacteria	chpE			ko:K06600,ko:K06895					ko00000,ko02000,ko02035	2.A.75.1,2.A.76			Bacteria	2INXA@201174,COG1280@1,COG1280@2	NA|NA|NA	E	LysE type translocator
MAG.T22.39_01316	525368.HMPREF0591_5352	6.4e-199	700.3	Mycobacteriaceae			1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	23756@1762,2IB5R@201174,COG0446@1,COG0446@2	NA|NA|NA	S	but shows high identity with sulfide-quinone reductase from chlorobium tepidum
MAG.T22.39_01319	1151118.KB895786_gene2417	6.4e-37	161.0	Micrococcaceae	VY92_09940			ko:K09796					ko00000,ko03110				Bacteria	1W9NR@1268,2IR3D@201174,COG2847@1,COG2847@2	NA|NA|NA	S	Copper chaperone PCu(A)C
MAG.T22.39_01320	479432.Sros_3398	1.3e-91	343.6	Streptosporangiales			1.11.1.19	ko:K15733					ko00000,ko01000				Bacteria	2GIUB@201174,4EICS@85012,COG2837@1,COG2837@2	NA|NA|NA	P	Dyp-type peroxidase family
MAG.T22.39_01321	662479.C440_16931	3.6e-28	131.3	Halobacteria													Archaea	23W96@183963,2XY9V@28890,arCOG00516@1,arCOG00516@2157	NA|NA|NA	S	Pyridoxamine 5'-phosphate
MAG.T22.39_01322	1504319.GM45_0125	1.4e-81	309.7	unclassified Actinobacteria (class)													Bacteria	2GM50@201174,3UWRY@52018,COG0697@1,COG0697@2	NA|NA|NA	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MAG.T22.39_01323	1194165.CAJF01000002_gene2174	7.1e-47	194.1	Microbacteriaceae				ko:K07149					ko00000				Bacteria	2GKA1@201174,4FNSN@85023,COG2364@1,COG2364@2	NA|NA|NA	S	membrane
MAG.T22.39_01324	935840.JAEQ01000002_gene3650	2.4e-17	95.5	Phyllobacteriaceae	bacB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017000,GO:0017144,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0046872,GO:0046914,GO:0050897	5.3.3.19	ko:K19547	ko01130,map01130	M00787			ko00000,ko00001,ko00002,ko01000				Bacteria	1RHMM@1224,2U9W3@28211,43MGY@69277,COG1917@1,COG1917@2	NA|NA|NA	S	Cupin domain
MAG.T22.39_01326	675635.Psed_5731	4.7e-38	164.5	Pseudonocardiales			1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120		R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000				Bacteria	2GK5R@201174,4E42U@85010,COG2068@1,COG2068@2	NA|NA|NA	S	MobA-like NTP transferase domain
MAG.T22.39_01327	526225.Gobs_4952	5.7e-131	474.2	Frankiales	MA20_09410			ko:K07402					ko00000				Bacteria	2GIZS@201174,4ERTW@85013,COG1975@1,COG1975@2	NA|NA|NA	O	XdhC Rossmann domain
MAG.T22.39_01328	1121272.KB903261_gene6129	1.1e-37	162.9	Micromonosporales	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.80,2.8.1.11,2.8.1.12	ko:K03635,ko:K21147	ko00790,ko01100,ko04122,map00790,map01100,map04122		R07459,R07461,R09395	RC00043,RC02507	ko00000,ko00001,ko01000				Bacteria	2IQ9F@201174,4DD4C@85008,COG0314@1,COG0314@2	NA|NA|NA	H	Molybdopterin biosynthesis MoaE protein
MAG.T22.39_01329	1304865.JAGF01000001_gene2527	6.2e-116	424.1	Cellulomonadaceae	moaA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000				Bacteria	2GN0V@201174,4F1Q4@85016,COG2896@1,COG2896@2	NA|NA|NA	H	Molybdenum Cofactor Synthesis C
MAG.T22.39_01330	1448389.BAVQ01000008_gene4166	4.4e-12	77.0	Bacteria	moaD		2.8.1.12	ko:K03636,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000				Bacteria	COG1977@1,COG1977@2	NA|NA|NA	H	Mo-molybdopterin cofactor metabolic process
MAG.T22.39_01331	526225.Gobs_4922	1.4e-41	176.4	Frankiales				ko:K09386					ko00000				Bacteria	2GKTQ@201174,4ESNJ@85013,COG3427@1,COG3427@2	NA|NA|NA	S	carbon monoxide dehydrogenase subunit G
MAG.T22.39_01332	469383.Cwoe_3030	6.6e-106	390.6	Rubrobacteria													Bacteria	2GMM2@201174,4CQYG@84995,COG0714@1,COG0714@2	NA|NA|NA	S	PFAM ATPase associated with various cellular activities, AAA_5
MAG.T22.39_01333	469383.Cwoe_3031	2.2e-91	342.8	Rubrobacteria				ko:K07161					ko00000				Bacteria	2GNTS@201174,4CRRF@84995,COG3552@1,COG3552@2	NA|NA|NA	S	von Willebrand factor, type A
MAG.T22.39_01334	1996.JOFO01000012_gene1542	2.5e-108	399.1	Streptosporangiales	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000				Bacteria	2GJC3@201174,4EHQA@85012,COG0303@1,COG0303@2	NA|NA|NA	H	MoeA C-terminal region (domain IV)
MAG.T22.39_01335	1033730.CAHG01000012_gene1955	2.8e-47	194.9	Propionibacteriales	moaC		4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Bacteria	2IHR6@201174,4DQPG@85009,COG0315@1,COG0315@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MAG.T22.39_01336	1120950.KB892750_gene6891	6e-53	213.8	Propionibacteriales	mog		2.8.1.12,4.6.1.17	ko:K03635,ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395,R11372	RC02507,RC03425	ko00000,ko00001,ko01000				Bacteria	2II28@201174,4DQU7@85009,COG0521@1,COG0521@2	NA|NA|NA	H	Probable molybdopterin binding domain
MAG.T22.39_01337	529884.Rhola_00004520	3.3e-66	258.8	Microbacteriaceae	pstC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051704,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iAF987.Gmet_2702,ic_1306.c4652	Bacteria	2GJDA@201174,4FKAD@85023,COG0573@1,COG0573@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
MAG.T22.39_01338	1504319.GM45_0540	3.2e-70	272.3	unclassified Actinobacteria (class)	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217	Bacteria	2I2F2@201174,3UWRX@52018,COG0581@1,COG0581@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01339	1504319.GM45_0535	1.3e-95	356.3	unclassified Actinobacteria (class)	pstB		3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Bacteria	2GJQ3@201174,3UWF6@52018,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MAG.T22.39_01340	529884.Rhola_00004550	3.2e-43	182.6	Microbacteriaceae				ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	2GJXD@201174,4FKUY@85023,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
MAG.T22.39_01341	446465.Bfae_25620	5.9e-12	79.0	Dermabacteraceae	pstS			ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	2GJXD@201174,4FBN8@85020,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
MAG.T22.39_01342	369723.Strop_1612	1.1e-60	239.6	Micromonosporales	perX												Bacteria	2IFXH@201174,4DIG7@85008,COG2210@1,COG2210@2	NA|NA|NA	S	DsrE/DsrF/DrsH-like family
MAG.T22.39_01343	369723.Strop_1611	1.1e-36	159.1	Micromonosporales	dsrC		1.8.5.4	ko:K11179,ko:K17218	ko00920,ko04122,map00920,map04122		R10152	RC03155	ko00000,ko00001,ko01000,ko03016				Bacteria	2IQB2@201174,4DJKP@85008,COG2920@1,COG2920@2	NA|NA|NA	P	DsrC like protein
MAG.T22.39_01344	1385519.N801_12760	1.5e-167	595.9	Intrasporangiaceae			1.8.5.4	ko:K17218	ko00920,map00920		R10152	RC03155	ko00000,ko00001,ko01000				Bacteria	2GRTN@201174,4FFV5@85021,COG0446@1,COG0446@2	NA|NA|NA	S	Oxidoreductase
MAG.T22.39_01345	1123320.KB889585_gene1776	3.7e-73	281.2	Actinobacteria	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190				ko00000,ko00001,ko01000			iNJ661.Rv3628	Bacteria	2GM7F@201174,COG0221@1,COG0221@2	NA|NA|NA	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MAG.T22.39_01346	644283.Micau_5891	4.9e-65	255.4	Micromonosporales	dacB		3.4.16.4	ko:K07259	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	2GJPH@201174,4DATD@85008,COG2027@1,COG2027@2	NA|NA|NA	M	D-alanyl-D-alanine carboxypeptidase
MAG.T22.39_01347	1095767.CAHD01000235_gene2843	1e-76	293.9	Actinobacteria	manA		5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000				Bacteria	2I8X4@201174,COG1482@1,COG1482@2	NA|NA|NA	G	mannose-6-phosphate isomerase
MAG.T22.39_01348	390989.JOEG01000027_gene2252	4.2e-64	251.9	Micromonosporales													Bacteria	2GJ8E@201174,4DAW7@85008,COG5282@1,COG5282@2	NA|NA|NA	S	Zincin-like metallopeptidase
MAG.T22.39_01349	1043205.AFYF01000063_gene2717	1.9e-61	243.0	Intrasporangiaceae	tilS		2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	2GJR4@201174,4FFMR@85021,COG0037@1,COG0037@2	NA|NA|NA	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MAG.T22.39_01350	1001240.GY21_06920	1.9e-71	275.4	Microbacteriaceae	hpt		2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016				Bacteria	2GMDZ@201174,4FM07@85023,COG0634@1,COG0634@2	NA|NA|NA	F	Phosphoribosyl transferase domain
MAG.T22.39_01351	1123319.AUBE01000001_gene1699	1.8e-260	905.2	Actinobacteria	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K03798		M00742			ko00000,ko00002,ko01000,ko01002,ko03110				Bacteria	2GJ4Q@201174,COG0465@1,COG0465@2	NA|NA|NA	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAG.T22.39_01352	67373.JOBF01000006_gene2525	1.8e-78	298.9	Actinobacteria	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000			iIT341.HP0928	Bacteria	2GP2P@201174,COG0302@1,COG0302@2	NA|NA|NA	H	GTP cyclohydrolase
MAG.T22.39_01353	1169152.AXVD01000002_gene3920	6.3e-79	300.8	Nocardiaceae	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJDQ@201174,4FUWS@85025,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAG.T22.39_01354	479435.Kfla_6463	4.1e-27	127.5	Propionibacteriales	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000				Bacteria	2IHSW@201174,4DRH9@85009,COG1539@1,COG1539@2	NA|NA|NA	H	Dihydroneopterin aldolase
MAG.T22.39_01355	883069.HMPREF9238_00875	1.7e-37	162.5	Actinobacteria	folK	GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0008150,GO:0016740,GO:0016772,GO:0016778,GO:0040007,GO:0043167,GO:0043169,GO:0046872	1.13.11.81,2.5.1.15,2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25,5.1.99.8	ko:K00796,ko:K00950,ko:K01495,ko:K01633,ko:K13940,ko:K17488	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841,M00842,M00843	R00428,R03066,R03067,R03503,R03504,R04639,R05046,R05048,R10348,R11037,R11073	RC00002,RC00017,RC00121,RC00263,RC00294,RC00323,RC00721,RC00842,RC00943,RC00945,RC01188,RC01479,RC02504,RC03131,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iLJ478.TM0041,iSBO_1134.SBO_0131	Bacteria	2H3G6@201174,4D4EV@85005,COG0801@1,COG0801@2,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MAG.T22.39_01356	1463887.KL590006_gene2534	4.7e-13	81.3	Actinobacteria													Bacteria	2DRQG@1,2IFEG@201174,33CMQ@2	NA|NA|NA	S	Protein of unknown function (DUF3180)
MAG.T22.39_01358	1348663.KCH_34740	2.6e-59	236.1	Kitasatospora	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333,ko:K05579,ko:K13378	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GKEZ@201174,2M0AF@2063,COG0649@1,COG0649@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_01359	1288083.AUKR01000019_gene146	1.2e-83	316.6	Actinobacteria													Bacteria	2I2F6@201174,COG5495@1,COG5495@2	NA|NA|NA	S	Oxidoreductase
MAG.T22.39_01360	644283.Micau_5858	7.8e-69	267.3	Micromonosporales	panC	GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3602c	Bacteria	2GJEQ@201174,4D99B@85008,COG0414@1,COG0414@2	NA|NA|NA	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MAG.T22.39_01361	1123320.KB889585_gene1808	3.3e-186	658.3	Actinobacteria	nadB		1.3.5.4,1.4.3.16,2.4.2.19	ko:K00244,ko:K00278,ko:K00767	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00115,M00150,M00173	R00357,R00481,R02164,R03348	RC00006,RC00045,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2IJ@201174,COG0029@1,COG0029@2	NA|NA|NA	H	Catalyzes the oxidation of L-aspartate to iminoaspartate
MAG.T22.39_01362	1079986.JH164862_gene6899	2.3e-90	339.0	Actinobacteria	nadC		1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000				Bacteria	2I2IP@201174,COG0157@1,COG0157@2	NA|NA|NA	H	Belongs to the NadC ModD family
MAG.T22.39_01363	1121272.KB903261_gene6476	2.8e-97	361.7	Micromonosporales	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1986	Bacteria	2GMRQ@201174,4D9W0@85008,COG1521@1,COG1521@2	NA|NA|NA	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MAG.T22.39_01364	1386089.N865_13000	1.3e-48	199.9	Actinobacteria				ko:K07025					ko00000				Bacteria	2GN5U@201174,COG1011@1,COG1011@2	NA|NA|NA	S	haloacid dehalogenase
MAG.T22.39_01365	28042.GU90_15560	4.1e-196	691.0	Pseudonocardiales	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	Bacteria	2GKE0@201174,4DZ2T@85010,COG1190@1,COG1190@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family
MAG.T22.39_01366	1463900.JOIX01000015_gene2667	3.9e-55	221.1	Actinobacteria	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0946	Bacteria	2GJBT@201174,COG1246@1,COG1246@2	NA|NA|NA	E	N-acetylglutamate synthase
MAG.T22.39_01367	935866.JAER01000005_gene148	9e-48	197.2	Propionibacteriales		GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783	3.5.1.28	ko:K01448,ko:K03727	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Bacteria	2GPA9@201174,4DS0S@85009,COG0860@1,COG0860@2	NA|NA|NA	M	Ami_3
MAG.T22.39_01368	44060.JODL01000016_gene4278	4.1e-256	891.0	Actinobacteria	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000			iJN678.ppc,iSFV_1184.SFV_4025	Bacteria	2GKDB@201174,COG2352@1,COG2352@2	NA|NA|NA	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MAG.T22.39_01370	1504319.GM45_4290	1.9e-190	672.2	unclassified Actinobacteria (class)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iNJ661.Rv2992c	Bacteria	2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAG.T22.39_01371	452652.KSE_51370	5.2e-86	324.3	Kitasatospora	fahA												Bacteria	2GN2G@201174,2M184@2063,COG0179@1,COG0179@2	NA|NA|NA	Q	Domain of unknown function (DUF2437)
MAG.T22.39_01372	269800.Tfu_0617	1.8e-202	712.2	Streptosporangiales	cimA		2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GKYT@201174,4EGZA@85012,COG0119@1,COG0119@2	NA|NA|NA	E	LeuA allosteric (dimerisation) domain
MAG.T22.39_01373	1206733.BAGC01000040_gene1682	1.7e-21	108.6	Nocardiaceae													Bacteria	2E3QV@1,2GQQZ@201174,32YNP@2,4G392@85025	NA|NA|NA	S	Domain of unknown function (DUF1905)
MAG.T22.39_01374	105425.BBPL01000006_gene7181	7.7e-139	500.4	Streptacidiphilus	ilvE	GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GKJ1@201174,2NHDF@228398,COG0115@1,COG0115@2	NA|NA|NA	EH	Amino-transferase class IV
MAG.T22.39_01375	469371.Tbis_2812	3.4e-133	481.5	Pseudonocardiales	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GK44@201174,4DXBP@85010,COG0473@1,COG0473@2	NA|NA|NA	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MAG.T22.39_01376	1504319.GM45_4265	3.4e-255	887.5	unclassified Actinobacteria (class)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GISX@201174,3UW8G@52018,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAG.T22.39_01377	37919.EP51_24640	4e-50	205.3	Nocardiaceae	ydeK												Bacteria	2GP9G@201174,4FYSV@85025,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_01378	457429.ABJI02000223_gene777	3.7e-200	704.5	Actinobacteria	serA		1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJGA@201174,COG0111@1,COG0111@2	NA|NA|NA	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAG.T22.39_01379	585531.HMPREF0063_12111	2.9e-120	438.7	Actinobacteria	phrB		4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Bacteria	2GJPV@201174,COG0415@1,COG0415@2	NA|NA|NA	L	FAD binding domain of DNA photolyase
MAG.T22.39_01380	1032480.MLP_18030	8.1e-156	556.6	Propionibacteriales	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKXA@201174,4DNFA@85009,COG0059@1,COG0059@2	NA|NA|NA	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MAG.T22.39_01381	1048339.KB913029_gene3460	1.2e-70	272.7	Frankiales	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ilvN,iJN678.ilvN	Bacteria	2GJCH@201174,4ESEU@85013,COG0440@1,COG0440@2	NA|NA|NA	E	Acetolactate synthase, small subunit
MAG.T22.39_01382	1120950.KB892741_gene2671	2.1e-273	948.0	Propionibacteriales	ilvB		2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKU4@201174,4DNJX@85009,COG0028@1,COG0028@2	NA|NA|NA	E	Thiamine pyrophosphate enzyme, central domain
MAG.T22.39_01383	318424.EU78_01125	5.7e-260	903.3	Mycobacteriaceae	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000				Bacteria	233VR@1762,2GJIJ@201174,COG0129@1,COG0129@2	NA|NA|NA	E	Belongs to the ILVD EDD family
MAG.T22.39_01384	1120950.KB892741_gene2668	3.8e-64	251.9	Propionibacteriales													Bacteria	2GP09@201174,4DNYY@85009,COG0111@1,COG0111@2	NA|NA|NA	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
MAG.T22.39_01385	269800.Tfu_0609	2.5e-198	698.4	Streptosporangiales	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2GJJH@201174,4EHUN@85012,COG0064@1,COG0064@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T22.39_01386	105420.BBPO01000030_gene6682	3.8e-215	754.2	Streptacidiphilus	gatA		6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2GJK5@201174,2NHY5@228398,COG0154@1,COG0154@2	NA|NA|NA	J	Amidase
MAG.T22.39_01387	2002.JOEQ01000012_gene5693	8.6e-26	122.9	Streptosporangiales	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100		R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029				Bacteria	2IQJN@201174,4EJUI@85012,COG0721@1,COG0721@2	NA|NA|NA	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAG.T22.39_01388	1504319.GM45_4210	2.3e-229	802.0	unclassified Actinobacteria (class)	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	2GJUY@201174,3UW7F@52018,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MAG.T22.39_01389	44060.JODL01000001_gene2960	2.3e-62	246.1	Actinobacteria			2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMPS@201174,COG0620@1,COG0620@2	NA|NA|NA	E	Methionine synthase
MAG.T22.39_01390	479433.Caci_1306	5.8e-112	411.0	Actinobacteria	mnmA		2.8.1.13	ko:K00566	ko04122,map04122		R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016				Bacteria	2GIUQ@201174,COG0482@1,COG0482@2	NA|NA|NA	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MAG.T22.39_01391	1869.MB27_22590	3.3e-121	441.8	Micromonosporales	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Bacteria	2GKUT@201174,4DB1C@85008,COG1104@1,COG1104@2	NA|NA|NA	E	Cysteine desulfurase
MAG.T22.39_01392	1122611.KB903963_gene4735	9.3e-98	363.6	Streptosporangiales	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03522					ko00000,ko04147				Bacteria	2GJWH@201174,4EGI3@85012,COG2025@1,COG2025@2	NA|NA|NA	C	Electron transfer flavoprotein domain
MAG.T22.39_01393	469371.Tbis_2846	1.6e-87	329.3	Pseudonocardiales	etfB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0016627,GO:0016628,GO:0022900,GO:0030312,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108	ko:K03521,ko:K22431					ko00000,ko01000			iAF987.Gmet_2067,iHN637.CLJU_RS19405	Bacteria	2GKV6@201174,4E0JQ@85010,COG2086@1,COG2086@2	NA|NA|NA	C	Electron transfer flavoprotein
MAG.T22.39_01394	675635.Psed_1741	1.7e-66	259.2	Pseudonocardiales		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944											Bacteria	2GNUB@201174,4DZBZ@85010,COG0110@1,COG0110@2	NA|NA|NA	S	Bacterial transferase hexapeptide (six repeats)
MAG.T22.39_01395	65497.JODV01000001_gene3582	2e-100	372.5	Pseudonocardiales													Bacteria	2HIHA@201174,4DY0M@85010,COG0500@1,COG2226@2	NA|NA|NA	Q	Methylase involved in ubiquinone menaquinone biosynthesis
MAG.T22.39_01396	1157637.KB892146_gene7080	1.1e-228	799.7	Actinobacteria	glgX		3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261		ko00000,ko00001,ko00002,ko01000		CBM48,GH13		Bacteria	2GJ00@201174,COG1523@1,COG1523@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 13 family
MAG.T22.39_01397	1122933.JNIY01000004_gene2571	0.0	1154.8	Cellulomonadaceae	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1,2.4.1.8	ko:K00688,ko:K00691	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R01555,R02111	RC00049	ko00000,ko00001,ko01000		GH65,GT35		Bacteria	2GIVZ@201174,4F0SU@85016,COG0058@1,COG0058@2	NA|NA|NA	G	Protein of unknown function (DUF3417)
MAG.T22.39_01398	358823.DF19_30510	3e-223	781.6	Actinobacteria													Bacteria	2GJKR@201174,COG0366@1,COG0366@2	NA|NA|NA	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB
MAG.T22.39_01399	351607.Acel_0676	9.6e-308	1062.4	Frankiales	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13		Bacteria	2GJ5C@201174,4ERUN@85013,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAG.T22.39_01400	1120949.KB903307_gene1304	1.1e-18	99.8	Micromonosporales	trxA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko03110				Bacteria	2GJ7B@201174,4D937@85008,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin
MAG.T22.39_01401	1043493.BBLU01000014_gene1262	6.2e-23	113.6	Actinobacteria	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63	ko:K00567,ko:K10778					ko00000,ko01000,ko03000,ko03400				Bacteria	2IHP1@201174,COG0350@1,COG0350@2	NA|NA|NA	L	methyltransferase
MAG.T22.39_01402	397278.JOJN01000001_gene2592	3e-132	479.2	Propionibacteriales	pknL		2.7.11.1	ko:K12132					ko00000,ko01000,ko01001				Bacteria	2GJ1J@201174,4DPC3@85009,COG0515@1,COG0515@2,COG2815@1,COG2815@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T22.39_01403	983917.RGE_14960	1e-18	100.1	unclassified Burkholderiales													Bacteria	1KM5K@119065,1RI98@1224,2VSFE@28216,COG3172@1,COG3172@2	NA|NA|NA	H	AAA domain
MAG.T22.39_01404	326424.FRAAL5074	1.7e-28	132.1	Frankiales	crtY												Bacteria	2CPEY@1,2I84R@201174,32SIY@2,4ETKH@85013	NA|NA|NA	S	lycopene cyclase
MAG.T22.39_01405	1504319.GM45_0925	6.2e-29	133.7	Bacteria													Bacteria	2E9MI@1,333U6@2	NA|NA|NA		
MAG.T22.39_01406	1504319.GM45_0995	2.9e-107	395.2	unclassified Actinobacteria (class)	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	2HFT6@201174,3UXMW@52018,COG1562@1,COG1562@2	NA|NA|NA	I	Squalene/phytoene synthase
MAG.T22.39_01407	1504319.GM45_1000	3.3e-214	751.1	unclassified Actinobacteria (class)	crtI		1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110		R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000				Bacteria	2GJAV@201174,3UXB3@52018,COG1233@1,COG1233@2	NA|NA|NA	Q	Flavin containing amine oxidoreductase
MAG.T22.39_01408	1394178.AWOO02000073_gene2262	6e-104	384.4	Streptosporangiales	idsA		2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006				Bacteria	2GJEK@201174,4EFMM@85012,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
MAG.T22.39_01409	1048339.KB913029_gene4363	1.1e-97	363.2	Frankiales	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJTN@201174,4ERKZ@85013,COG0685@1,COG0685@2	NA|NA|NA	E	Methylenetetrahydrofolate reductase
MAG.T22.39_01410	35754.JNYJ01000001_gene7085	1.6e-104	386.7	Micromonosporales	cvrA			ko:K11105					ko00000,ko02000	2.A.36.6			Bacteria	2GJ9B@201174,4D9E3@85008,COG3263@1,COG3263@2	NA|NA|NA	P	Sodium/hydrogen exchanger family
MAG.T22.39_01411	1306174.JODP01000009_gene6586	7e-153	547.4	Actinobacteria	crtD		1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9	ko:K01854,ko:K09845,ko:K10027	ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110		R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692	RC00317,RC01214,RC02080,RC02088,RC02396,RC02605	ko00000,ko00001,ko01000				Bacteria	2GJAV@201174,COG1233@1,COG1233@2	NA|NA|NA	Q	phytoene
MAG.T22.39_01412	66373.JOFQ01000033_gene4066	1.6e-73	283.1	Actinobacteria													Bacteria	2IBP1@201174,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
MAG.T22.39_01413	408672.NBCG_04989	2.3e-20	104.8	Propionibacteriales	QU41_18010		2.4.2.18	ko:K00766,ko:K03719	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000,ko03000,ko03036				Bacteria	2IQD4@201174,4DRN1@85009,COG1522@1,COG1522@2	NA|NA|NA	K	Lrp/AsnC ligand binding domain
MAG.T22.39_01414	67352.JODS01000009_gene7469	9.2e-24	116.7	Actinobacteria	badA		6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120		R00982	RC00004,RC00174	ko00000,ko00001,ko01000				Bacteria	2GJVK@201174,COG0365@1,COG0365@2	NA|NA|NA	I	Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MAG.T22.39_01415	469383.Cwoe_3891	1e-48	200.3	Bacteria													Bacteria	COG1802@1,COG1802@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_01416	1177594.MIC448_930014	7.7e-124	450.7	Actinobacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2I9D3@201174,COG0683@1,COG0683@2	NA|NA|NA	E	amino acid
MAG.T22.39_01417	1177594.MIC448_930013	1.1e-61	243.4	Microbacteriaceae				ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMEE@201174,4FN03@85023,COG0411@1,COG0411@2	NA|NA|NA	E	Branched-chain amino acid ATP-binding cassette transporter
MAG.T22.39_01418	1177594.MIC448_930012	3.7e-67	261.5	Microbacteriaceae				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GKSQ@201174,4FN9B@85023,COG0410@1,COG0410@2	NA|NA|NA	E	ABC transporter
MAG.T22.39_01419	1177594.MIC448_930011	6.6e-74	284.3	Actinobacteria	livH			ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2IAMH@201174,COG0559@1,COG0559@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01420	1177594.MIC448_930010	9.9e-72	277.3	Actinobacteria				ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2IF69@201174,COG4177@1,COG4177@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01421	446471.Xcel_0315	3.6e-147	528.5	Actinobacteria			1.2.7.8	ko:K00180					br01601,ko00000,ko01000				Bacteria	2IA5E@201174,COG1014@1,COG1014@2	NA|NA|NA	C	Pyruvate ferredoxin/flavodoxin oxidoreductase
MAG.T22.39_01422	446471.Xcel_0314	2.1e-310	1071.2	Actinobacteria			1.2.7.8	ko:K00179					br01601,ko00000,ko01000				Bacteria	2GKBW@201174,COG4231@1,COG4231@2	NA|NA|NA	C	indolepyruvate ferredoxin oxidoreductase
MAG.T22.39_01423	1463855.JOHV01000046_gene225	7.2e-166	590.1	Actinobacteria	nagI		1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120		R02656	RC00764	ko00000,ko00001,ko01000				Bacteria	2GKAE@201174,COG3435@1,COG3435@2	NA|NA|NA	Q	Pfam Cupin
MAG.T22.39_01424	330084.JNYZ01000003_gene2372	1.2e-135	489.6	Pseudonocardiales	nitA		3.5.5.1,3.5.5.7	ko:K01501,ko:K01502	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120		R00540,R01887,R03093,R03542,R05358,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC01336,RC02811	ko00000,ko00001,ko01000				Bacteria	2H03Y@201174,4E581@85010,COG0388@1,COG0388@2	NA|NA|NA	S	Carbon-nitrogen hydrolase
MAG.T22.39_01425	330084.JNYZ01000003_gene2371	1.4e-108	399.4	Pseudonocardiales													Bacteria	2GN2G@201174,4E0EH@85010,COG0179@1,COG0179@2	NA|NA|NA	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase
MAG.T22.39_01426	1463855.JOHV01000046_gene223	9.4e-93	346.7	Actinobacteria	maiA	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0022607,GO:0043933,GO:0044085,GO:0050076,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840	5.2.1.1	ko:K01799	ko00650,ko00760,ko01120,map00650,map00760,map01120	M00622	R01087	RC00448	ko00000,ko00001,ko00002,ko01000				Bacteria	2HRMA@201174,COG3473@1,COG3473@2	NA|NA|NA	Q	Catalyzes the conversion of maleate to fumarate
MAG.T22.39_01427	1306174.JODP01000001_gene5329	8.1e-12	76.6	Actinobacteria	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K04749					ko00000,ko03021				Bacteria	2IHQG@201174,COG1366@1,COG1366@2	NA|NA|NA	T	Belongs to the anti-sigma-factor antagonist family
MAG.T22.39_01428	1157637.KB892122_gene479	4e-288	997.3	Actinobacteria	hppA		3.6.1.1	ko:K15987	ko00190,map00190				ko00000,ko00001,ko01000	3.A.10.1			Bacteria	2GN8B@201174,COG3808@1,COG3808@2	NA|NA|NA	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force
MAG.T22.39_01430	1463900.JOIX01000015_gene2577	1.3e-282	979.2	Actinobacteria	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168					ko00000,ko01000,ko03032,ko03400				Bacteria	2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAG.T22.39_01431	1504319.GM45_3905	8.1e-58	230.3	unclassified Actinobacteria (class)	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNTI@201174,3UWKT@52018,COG0125@1,COG0125@2	NA|NA|NA	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MAG.T22.39_01432	31964.CMS0860	1.2e-28	133.3	Actinobacteria	hipB	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K07075,ko:K15773					ko00000,ko02048,ko03000				Bacteria	2I3WY@201174,COG1396@1,COG1396@2	NA|NA|NA	K	Helix-turn-helix
MAG.T22.39_01433	365528.KB891230_gene1835	2.7e-17	95.5	Actinobacteria													Bacteria	2DMWY@1,2ISFN@201174,32U6G@2	NA|NA|NA		
MAG.T22.39_01434	479435.Kfla_0588	1.6e-86	326.6	Propionibacteriales	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJ8C@201174,4DNVR@85009,COG0470@1,COG0470@2	NA|NA|NA	L	DNA polymerase III
MAG.T22.39_01436	1385521.N803_10230	6.6e-106	391.3	Intrasporangiaceae	slpD												Bacteria	2GJYS@201174,4FF86@85021,COG0596@1,COG0596@2	NA|NA|NA	S	proteinase
MAG.T22.39_01437	2002.JOEQ01000003_gene2407	1.2e-29	135.6	Streptosporangiales				ko:K21600					ko00000,ko03000				Bacteria	2IQAC@201174,4EK99@85012,COG1937@1,COG1937@2	NA|NA|NA	S	Metal-sensitive transcriptional repressor
MAG.T22.39_01438	223184.AS25_02490	6.2e-10	69.7	Micrococcaceae	copP												Bacteria	1WABX@1268,2HTCX@201174,COG2608@1,COG2608@2	NA|NA|NA	P	Heavy-metal-associated domain
MAG.T22.39_01439	273677.BW34_01733	2.1e-182	646.0	Microbacteriaceae			3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5			Bacteria	2GIRF@201174,4FKU0@85023,COG2217@1,COG2217@2	NA|NA|NA	P	E1-E2 ATPase
MAG.T22.39_01440	661478.OP10G_3562	5.7e-204	717.6	Bacteria													Bacteria	COG0243@1,COG0243@2	NA|NA|NA	C	molybdopterin cofactor binding
MAG.T22.39_01443	935866.JAER01000003_gene1297	5.2e-08	63.9	Propionibacteriales				ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	2GJBE@201174,4DRE5@85009,COG1734@1,COG1734@2	NA|NA|NA	T	Prokaryotic dksA/traR C4-type zinc finger
MAG.T22.39_01444	1075090.GOAMR_08_00070	1.4e-192	679.1	Gordoniaceae	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GKXG@201174,4GC7Q@85026,COG0334@1,COG0334@2	NA|NA|NA	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
MAG.T22.39_01446	1194165.CAJF01000046_gene3446	3.6e-127	461.1	Microbacteriaceae	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	Bacteria	2GIU6@201174,4FKER@85023,COG0508@1,COG0508@2,COG0567@1,COG0567@2	NA|NA|NA	C	2-oxoglutarate dehydrogenase C-terminal
MAG.T22.39_01447	543734.LCABL_29170	3e-13	81.3	Lactobacillaceae													Bacteria	1TPWP@1239,3F3WG@33958,4HABC@91061,COG1063@1,COG1063@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T22.39_01448	1396141.BATP01000057_gene3008	1.2e-45	190.3	Verrucomicrobiae													Bacteria	2IVC5@203494,46U2M@74201,COG1830@1,COG1830@2	NA|NA|NA	G	DeoC/LacD family aldolase
MAG.T22.39_01449	926550.CLDAP_38640	2.4e-87	328.9	Chloroflexi	hopR		1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100		R05066	RC00099	ko00000,ko00001,ko01000				Bacteria	2G8J4@200795,COG2084@1,COG2084@2	NA|NA|NA	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MAG.T22.39_01450	345341.KUTG_04487	5.1e-28	131.7	Pseudonocardiales	glpR												Bacteria	2H5X4@201174,4DY5K@85010,COG1349@1,COG1349@2	NA|NA|NA	K	Bacterial regulatory proteins, deoR family
MAG.T22.39_01451	1304874.JAFY01000002_gene558	1.4e-172	612.8	Synergistetes	xylB2		2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000				Bacteria	3TBDX@508458,COG1070@1,COG1070@2	NA|NA|NA	G	FGGY family of carbohydrate kinases, N-terminal domain
MAG.T22.39_01454	1504319.GM45_3610	7.2e-78	297.4	Actinobacteria													Bacteria	2I95D@201174,2ZB4E@2,arCOG06481@1	NA|NA|NA		
MAG.T22.39_01457	344747.PM8797T_09044	3.6e-40	172.6	Planctomycetes													Bacteria	2J1PP@203682,COG0654@1,COG0654@2	NA|NA|NA	CH	FAD binding domain
MAG.T22.39_01458	1078020.KEK_02831	1.1e-07	65.5	Mycobacteriaceae	devS		2.7.13.3	ko:K07682,ko:K20487	ko02020,ko02024,map02020,map02024	M00482,M00816			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	23337@1762,2GIWI@201174,COG3850@1,COG3850@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_01459	1121382.JQKG01000002_gene4527	6.7e-20	104.4	Bacteria				ko:K03413,ko:K07684,ko:K07689	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00471,M00475,M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
MAG.T22.39_01460	1894.JOER01000047_gene1515	3e-175	621.7	Actinobacteria													Bacteria	2GIZA@201174,COG0702@1,COG0702@2	NA|NA|NA	GM	Nad-dependent epimerase dehydratase
MAG.T22.39_01461	10224.XP_006823013.1	1e-35	159.1	Bilateria			2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414				ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812				Metazoa	38BAS@33154,3B9IR@33208,3CRJW@33213,KOG0613@1,KOG0613@2759	NA|NA|NA	T	myosin light chain kinase activity
MAG.T22.39_01464	1123024.AUII01000003_gene3314	7.5e-49	201.4	Pseudonocardiales	rmuC			ko:K09760					ko00000				Bacteria	2GP4U@201174,4DZEY@85010,COG1322@1,COG1322@2	NA|NA|NA	S	RmuC family
MAG.T22.39_01465	1121020.JIAG01000002_gene922	6.7e-16	90.1	Bacteria		GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0032879,GO:0032880,GO:0050708,GO:0050789,GO:0050794,GO:0051046,GO:0051049,GO:0051223,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0097159,GO:1901363,GO:1903530											Bacteria	COG1396@1,COG1396@2	NA|NA|NA	K	sequence-specific DNA binding
MAG.T22.39_01467	329726.AM1_1057	9.8e-66	257.3	Cyanobacteria													Bacteria	1GR4N@1117,2DBBI@1,2Z888@2	NA|NA|NA	S	YHYH protein
MAG.T22.39_01468	1122622.ATWJ01000008_gene2983	1.4e-33	149.4	Intrasporangiaceae													Bacteria	2I8ND@201174,4FGUM@85021,COG3832@1,COG3832@2	NA|NA|NA	S	Activator of Hsp90 ATPase homolog 1-like protein
MAG.T22.39_01469	2045.KR76_22675	1.9e-32	146.7	Propionibacteriales				ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2IB31@201174,4DS3E@85009,COG2197@1,COG2197@2	NA|NA|NA	K	helix_turn_helix, Lux Regulon
MAG.T22.39_01470	864051.BurJ1DRAFT_4584	3.6e-103	382.1	Betaproteobacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1MVBG@1224,2VMGI@28216,COG0683@1,COG0683@2	NA|NA|NA	E	Periplasmic binding protein
MAG.T22.39_01471	864051.BurJ1DRAFT_4585	1.4e-64	253.1	Proteobacteria			3.6.3.22	ko:K01995,ko:K10822	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4			Bacteria	1R1VT@1224,COG0411@1,COG0411@2	NA|NA|NA	E	Branched-chain amino acid ATP-binding cassette transporter
MAG.T22.39_01472	314264.ROS217_00380	3.3e-79	301.6	Alphaproteobacteria				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1R543@1224,2U1M4@28211,COG0410@1,COG0410@2	NA|NA|NA	E	ABC transporter
MAG.T22.39_01473	1120792.JAFV01000001_gene769	5.5e-68	264.6	Alphaproteobacteria				ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1N4QK@1224,2U1I0@28211,COG0559@1,COG0559@2	NA|NA|NA	E	Branched-chain amino acid transport system / permease component
MAG.T22.39_01474	1504319.GM45_1640	5.8e-144	518.1	unclassified Actinobacteria (class)	mrcB		2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	2GK21@201174,3UX6W@52018,COG0744@1,COG0744@2	NA|NA|NA	M	Transglycosylase
MAG.T22.39_01475	105420.BBPO01000017_gene5342	4.6e-87	328.6	Streptacidiphilus													Bacteria	2GJYA@201174,2NEKQ@228398,COG5650@1,COG5650@2	NA|NA|NA	S	Glycosyltransferase family 87
MAG.T22.39_01477	931627.MycrhDRAFT_2135	3.7e-27	127.9	Mycobacteriaceae	vapC												Bacteria	239XI@1762,2GR4U@201174,COG4113@1,COG4113@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_01478	1122609.AUGT01000019_gene311	6.9e-63	248.1	Propionibacteriales													Bacteria	2GJJX@201174,4DNS3@85009,COG0787@1,COG0787@2	NA|NA|NA	M	Alanine racemase, N-terminal domain
MAG.T22.39_01479	1463887.KL589982_gene4738	1.5e-105	389.8	Actinobacteria	femA												Bacteria	2GJUD@201174,COG2348@1,COG2348@2	NA|NA|NA	V	Methicillin resistance protein
MAG.T22.39_01480	1068980.ARVW01000001_gene6728	3.9e-97	361.3	Pseudonocardiales	xth		3.1.11.2,6.5.1.1	ko:K01142,ko:K01971	ko03410,ko03450,map03410,map03450		R00381	RC00005	ko00000,ko00001,ko01000,ko03400				Bacteria	2GKEW@201174,4DY2W@85010,COG0708@1,COG0708@2	NA|NA|NA	L	Exodeoxyribonuclease III xth
MAG.T22.39_01481	694427.Palpr_2962	1.5e-16	94.7	Porphyromonadaceae				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	2315R@171551,2G0YK@200643,4PNU0@976,COG2911@1,COG2911@2	NA|NA|NA	S	Protein conserved in bacteria
MAG.T22.39_01482	529884.Rhola_00013260	1.3e-31	143.3	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HT82@201174,4FSEQ@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_01483	529884.Rhola_00013270	1.6e-17	97.8	Microbacteriaceae													Bacteria	2BFXJ@1,2HTFG@201174,329T7@2,4FT9Y@85023	NA|NA|NA		
MAG.T22.39_01486	263358.VAB18032_04315	5e-34	150.2	Micromonosporales	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904		ko:K02990	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	2IQHD@201174,4DEAX@85008,COG0360@1,COG0360@2	NA|NA|NA	J	Binds together with S18 to 16S ribosomal RNA
MAG.T22.39_01487	1122247.C731_4270	3.3e-56	224.6	Mycobacteriaceae	ssb	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	232AP@1762,2GMM3@201174,COG0629@1,COG0629@2	NA|NA|NA	L	Single-stranded DNA-binding protein
MAG.T22.39_01488	479431.Namu_5367	6e-23	113.2	Frankiales	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02963,ko:K03111,ko:K15125	ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133	M00178			br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400				Bacteria	2IQ92@201174,4ESZ0@85013,COG0238@1,COG0238@2	NA|NA|NA	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MAG.T22.39_01489	479435.Kfla_6998	1.5e-45	189.1	Propionibacteriales	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02939	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKX7@201174,4DQKG@85009,COG0359@1,COG0359@2	NA|NA|NA	J	binds to the 23S rRNA
MAG.T22.39_01490	1294273.roselon_00693	2.6e-23	115.2	Alphaproteobacteria													Bacteria	1MZJ4@1224,2UG35@28211,COG3152@1,COG3152@2	NA|NA|NA	S	membrane
MAG.T22.39_01492	253839.SSNG_03577	4.8e-37	161.0	Actinobacteria	ptpA		3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	2IM0Q@201174,COG0394@1,COG0394@2	NA|NA|NA	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAG.T22.39_01493	479432.Sros_9348	1.3e-193	682.6	Streptosporangiales	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112				ko00000,ko00001,ko01000,ko03032				Bacteria	2GKXQ@201174,4EH2H@85012,COG0305@1,COG0305@2	NA|NA|NA	L	Participates in initiation and elongation during chromosome replication
MAG.T22.39_01494	553973.CLOHYLEM_05787	1.3e-62	246.5	Lachnoclostridium													Bacteria	1UETI@1239,220GY@1506553,24BBC@186801,COG1028@1,COG1028@2	NA|NA|NA	IQ	dehydrogenase reductase
MAG.T22.39_01496	1306174.JODP01000002_gene5970	5e-81	307.8	Actinobacteria	cobB			ko:K12410					ko00000,ko01000				Bacteria	2GJI3@201174,COG0846@1,COG0846@2	NA|NA|NA	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
MAG.T22.39_01497	391037.Sare_0141	3.1e-72	279.3	Micromonosporales		GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085											Bacteria	2HB3P@201174,4DCV1@85008,COG2271@1,COG2271@2	NA|NA|NA	G	PFAM major facilitator superfamily MFS_1
MAG.T22.39_01499	1396141.BATP01000059_gene2589	9.9e-67	260.8	Bacteria													Bacteria	COG2017@1,COG2017@2	NA|NA|NA	G	converts alpha-aldose to the beta-anomer
MAG.T22.39_01500	1123023.JIAI01000012_gene9229	2.1e-12	79.3	Actinobacteria	lysN		1.1.3.46,2.6.1.103	ko:K00375,ko:K16422,ko:K16423	ko00261,ko01055,ko01130,map00261,map01055,map01130		R06626,R06633,R06634	RC00006,RC00240,RC01104	ko00000,ko00001,ko01000,ko03000				Bacteria	2I409@201174,COG1167@1,COG1167@2	NA|NA|NA	K	AAA domain
MAG.T22.39_01501	1123023.JIAI01000012_gene9228	1.1e-45	190.7	Actinobacteria	lacC		2.7.1.11,2.7.1.144,2.7.1.56	ko:K00882,ko:K00917,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK7E@201174,COG1105@1,COG1105@2	NA|NA|NA	G	Belongs to the carbohydrate kinase PfkB family
MAG.T22.39_01502	1123023.JIAI01000012_gene9227	1.9e-77	296.2	Pseudonocardiales				ko:K02529					ko00000,ko03000				Bacteria	2GMGS@201174,4DZP4@85010,COG1609@1,COG1609@2	NA|NA|NA	K	helix_turn _helix lactose operon repressor
MAG.T22.39_01503	1123023.JIAI01000012_gene9226	1.2e-90	340.5	Pseudonocardiales	rhaB		2.7.1.17,2.7.1.5	ko:K00848,ko:K00854	ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120	M00014	R01639,R01902,R03014	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000				Bacteria	2IE7F@201174,4EB03@85010,COG1070@1,COG1070@2	NA|NA|NA	G	FGGY family of carbohydrate kinases, N-terminal domain
MAG.T22.39_01504	1123023.JIAI01000012_gene9225	4.2e-95	354.8	Pseudonocardiales	lacD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061595,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	4.1.2.40,4.1.2.57	ko:K01635,ko:K01671	ko00052,ko01100,ko02024,map00052,map01100,map02024		R01069,R10760	RC00438,RC00439	ko00000,ko00001,ko01000				Bacteria	2IB7A@201174,4E70G@85010,COG3684@1,COG3684@2	NA|NA|NA	G	DeoC/LacD family aldolase
MAG.T22.39_01505	1123023.JIAI01000012_gene9224	3.9e-91	341.3	Pseudonocardiales			3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	2GJDV@201174,4E157@85010,COG1129@1,COG1129@2	NA|NA|NA	G	ATPases associated with a variety of cellular activities
MAG.T22.39_01506	1123023.JIAI01000012_gene9223	4.2e-102	378.3	Pseudonocardiales				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJDW@201174,4E15R@85010,COG1172@1,COG1172@2	NA|NA|NA	G	Branched-chain amino acid transport system / permease component
MAG.T22.39_01507	1123023.JIAI01000012_gene9222	1.2e-92	346.7	Pseudonocardiales	rbsB			ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GNSX@201174,4E06J@85010,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T22.39_01508	314256.OG2516_07081	6.7e-56	224.2	Alphaproteobacteria													Bacteria	1MV0A@1224,2TRAN@28211,COG4221@1,COG4221@2	NA|NA|NA	S	Dehydrogenase
MAG.T22.39_01509	446470.Snas_4067	4.9e-57	228.0	Actinobacteria													Bacteria	2IJNY@201174,COG3347@1,COG3347@2	NA|NA|NA	IQ	Class II Aldolase and Adducin N-terminal domain
MAG.T22.39_01510	714083.JH370377_gene1284	4.4e-74	284.6	Microbacteriaceae													Bacteria	2GK20@201174,4FRNZ@85023,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T22.39_01511	1123321.KB905816_gene2938	1.7e-95	356.7	Actinobacteria	rhaB		2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120		R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GISK@201174,COG1070@1,COG1070@2	NA|NA|NA	G	Carbohydrate kinase
MAG.T22.39_01512	1504319.GM45_5885	0.0	1274.6	unclassified Actinobacteria (class)	leuS		6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJI1@201174,3UWBT@52018,COG0495@1,COG0495@2	NA|NA|NA	J	Leucyl-tRNA synthetase, Domain 2
MAG.T22.39_01513	1223523.H340_13322	2.7e-61	242.3	Actinobacteria													Bacteria	2GIUV@201174,COG1307@1,COG1307@2	NA|NA|NA	S	DegV family
MAG.T22.39_01514	1479623.JHEL01000015_gene485	2.5e-31	142.5	Microbacteriaceae	comEA			ko:K02237		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	2IQDC@201174,4FPAM@85023,COG1555@1,COG1555@2	NA|NA|NA	L	SLBB domain
MAG.T22.39_01515	1048339.KB913029_gene4829	2.5e-88	333.6	Frankiales	comEC			ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	2GJGR@201174,4ES7C@85013,COG0658@1,COG0658@2,COG2333@1,COG2333@2	NA|NA|NA	S	ComEC Rec2-related protein
MAG.T22.39_01516	1146883.BLASA_2073	9.1e-07	60.1	Actinobacteria													Bacteria	2ERPP@1,2GYWR@201174,33J91@2	NA|NA|NA		
MAG.T22.39_01517	1048339.KB913029_gene4828	9.3e-48	197.6	Frankiales	holA		2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GNMZ@201174,4ESK0@85013,COG1466@1,COG1466@2	NA|NA|NA	L	DNA polymerase III, delta subunit
MAG.T22.39_01518	585531.HMPREF0063_11259	1.2e-20	105.5	Propionibacteriales	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02968	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQ73@201174,4DSB6@85009,COG0268@1,COG0268@2	NA|NA|NA	J	Binds directly to 16S ribosomal RNA
MAG.T22.39_01519	1048339.KB913029_gene4817	1.8e-291	1008.1	Frankiales	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K03596	ko05134,map05134				ko00000,ko00001				Bacteria	2GJAB@201174,4ERZ3@85013,COG0481@1,COG0481@2	NA|NA|NA	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MAG.T22.39_01520	36809.MAB_1663	2.3e-119	435.6	Mycobacteriaceae	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576										iNJ661.Rv2388c	Bacteria	233HD@1762,2GJXX@201174,COG0635@1,COG0635@2	NA|NA|NA	H	Involved in the biosynthesis of porphyrin-containing compound
MAG.T22.39_01521	269800.Tfu_1694	1.2e-73	283.5	Streptosporangiales	ytnM			ko:K07090					ko00000				Bacteria	2GNPE@201174,4EI0K@85012,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T22.39_01522	235985.BBPN01000007_gene3310	2e-114	419.1	Streptacidiphilus	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03705					ko00000,ko03000				Bacteria	2GKF5@201174,2NGAY@228398,COG1420@1,COG1420@2	NA|NA|NA	K	HrcA protein C terminal domain
MAG.T22.39_01523	1157640.AQWO01000003_gene5834	8.3e-130	470.3	Actinobacteria	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944		ko:K03686					ko00000,ko03029,ko03110				Bacteria	2GK69@201174,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MAG.T22.39_01524	457429.ABJI02000541_gene1546	1.5e-47	196.4	Actinobacteria	rsmE	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.13.12.16,2.1.1.193	ko:K00459,ko:K09761	ko00910,map00910		R00025	RC02541,RC02759	ko00000,ko00001,ko01000,ko03009				Bacteria	2GKV4@201174,COG1385@1,COG1385@2,COG2070@1,COG2070@2	NA|NA|NA	J	2-nitropropane dioxygenase
MAG.T22.39_01525	58123.JOFJ01000001_gene3327	8.3e-33	146.4	Streptosporangiales	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.1.226,2.1.1.227	ko:K02503,ko:K06442					ko00000,ko01000,ko03009,ko04147				Bacteria	2IHPT@201174,4EJSG@85012,COG0537@1,COG0537@2	NA|NA|NA	FG	HIT domain
MAG.T22.39_01526	1123320.KB889675_gene4097	1.6e-129	469.2	Actinobacteria	phoH			ko:K06217					ko00000				Bacteria	2GK0W@201174,COG1702@1,COG1702@2	NA|NA|NA	T	phosphate starvation-inducible protein PhoH
MAG.T22.39_01527	1278308.KB907074_gene919	1.9e-32	145.6	Microbacteriaceae	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029				Bacteria	2GMUF@201174,4FNE8@85023,COG0319@1,COG0319@2	NA|NA|NA	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MAG.T22.39_01528	479432.Sros_2297	1e-126	460.3	Streptosporangiales	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GIWR@201174,4EFYG@85012,COG1253@1,COG1253@2	NA|NA|NA	S	Transporter associated domain
MAG.T22.39_01529	1463879.JOHP01000062_gene2662	2.8e-17	94.7	Actinobacteria	cdd		3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000				Bacteria	2IM42@201174,COG0295@1,COG0295@2	NA|NA|NA	F	cytidine deaminase
MAG.T22.39_01530	404380.Gbem_3934	2.5e-44	186.0	Deltaproteobacteria	ywfM			ko:K03298					ko00000,ko02000	2.A.7.3			Bacteria	1MUQ7@1224,2WPG4@28221,42T5N@68525,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_01531	500153.JOEK01000023_gene5824	4.1e-111	407.9	Actinobacteria	era	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363		ko:K03595					ko00000,ko03009,ko03029				Bacteria	2GJJE@201174,COG1159@1,COG1159@2	NA|NA|NA	M	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MAG.T22.39_01532	1172188.KB911821_gene1489	5.1e-95	354.8	Intrasporangiaceae													Bacteria	2GN4Y@201174,4FF71@85021,COG0628@1,COG0628@2	NA|NA|NA	S	AI-2E family transporter
MAG.T22.39_01533	1306990.BARG01000087_gene8668	3.8e-83	314.7	Actinobacteria	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944		ko:K03584	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	2GK81@201174,COG1381@1,COG1381@2	NA|NA|NA	L	Involved in DNA repair and RecF pathway recombination
MAG.T22.39_01534	1206732.BAGD01000050_gene1761	1.4e-112	412.5	Nocardiaceae	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110		R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006				Bacteria	2GIXF@201174,4FU1C@85025,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAG.T22.39_01535	1048339.KB913029_gene4781	2.6e-46	191.4	Frankiales	zur	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02076,ko:K03711,ko:K09823	ko02024,map02024				ko00000,ko00001,ko03000				Bacteria	2IKS3@201174,4ESZF@85013,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T22.39_01536	1045009.AFXQ01000011_gene475	2.4e-75	288.9	Micrococcaceae	hmuV		3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14			Bacteria	1WCNF@1268,2I5PA@201174,COG1120@1,COG1120@2	NA|NA|NA	HP	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T22.39_01537	1045009.AFXQ01000011_gene474	3.7e-90	338.2	Micrococcaceae	mntB			ko:K02075,ko:K09819		M00243,M00244			ko00000,ko00002,ko02000	3.A.1.15			Bacteria	1W8TI@1268,2GJ7H@201174,COG1108@1,COG1108@2	NA|NA|NA	P	ABC 3 transport family
MAG.T22.39_01538	1121933.AUHH01000020_gene2977	3.4e-71	275.4	Propionibacteriales	mntC			ko:K02077		M00244			ko00000,ko00002,ko02000	3.A.1.15			Bacteria	2GM1K@201174,4DRN8@85009,COG0803@1,COG0803@2	NA|NA|NA	P	Zinc-uptake complex component A periplasmic
MAG.T22.39_01539	1236902.ANAS01000009_gene2592	8.5e-07	60.1	Streptosporangiales													Bacteria	2C98I@1,2IQRU@201174,33EGA@2,4EKFZ@85012	NA|NA|NA		
MAG.T22.39_01540	345341.KUTG_03243	9.9e-16	89.7	Pseudonocardiales													Bacteria	2GQZB@201174,4E4C3@85010,COG2329@1,COG2329@2	NA|NA|NA	S	Antibiotic biosynthesis monooxygenase
MAG.T22.39_01541	457429.ABJI02000799_gene4428	1.6e-08	66.2	Actinobacteria	prsT			ko:K07100					ko00000				Bacteria	2GJUU@201174,COG1926@1,COG1926@2	NA|NA|NA	Q	phosphoribosyltransferase
MAG.T22.39_01542	44060.JODL01000012_gene3594	3.1e-120	438.3	Actinobacteria	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410	Bacteria	2GJ6H@201174,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MAG.T22.39_01543	1108045.GORHZ_055_00190	6.3e-32	144.1	Actinobacteria			2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	2IKIN@201174,COG4902@1,COG4902@2	NA|NA|NA	S	Uncharacterized protein domain (DUF2202)
MAG.T22.39_01544	367299.JOEE01000004_gene1264	7.3e-181	640.2	Intrasporangiaceae			5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2HBVS@201174,4FF6H@85021,COG0001@1,COG0001@2	NA|NA|NA	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T22.39_01545	979556.MTES_1666	2.2e-65	255.8	Microbacteriaceae													Bacteria	2GKW9@201174,4FRMA@85023,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_01546	1173027.Mic7113_0392	5.6e-42	178.7	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T22.39_01547	266940.Krad_3698	2.7e-33	150.2	Actinobacteria			2.7.13.3,3.1.3.3	ko:K07315,ko:K07654,ko:K07675	ko02020,map02020	M00461,M00473			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021				Bacteria	2IHH3@201174,COG2208@1,COG2208@2,COG3850@1,COG3850@2	NA|NA|NA	KT	stage II sporulation
MAG.T22.39_01548	1449347.JQLN01000007_gene1224	3.2e-58	232.3	Kitasatospora	yedA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Bacteria	2I91Y@201174,2M0VP@2063,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
MAG.T22.39_01549	649831.L083_4665	1e-161	576.6	Micromonosporales	cydA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337	Bacteria	2GJE4@201174,4DA5S@85008,COG1271@1,COG1271@2	NA|NA|NA	C	PFAM cytochrome bd ubiquinol oxidase subunit I
MAG.T22.39_01550	235985.BBPN01000059_gene7508	1e-105	390.2	Streptacidiphilus	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Bacteria	2GMFV@201174,2NF7J@228398,COG1294@1,COG1294@2	NA|NA|NA	C	Cytochrome bd terminal oxidase subunit II
MAG.T22.39_01551	996637.SGM_3583	2.1e-132	479.6	Actinobacteria	cydC			ko:K06148,ko:K16012,ko:K16013,ko:K16014	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1,3.A.1.129			Bacteria	2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2	NA|NA|NA	V	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD
MAG.T22.39_01552	1394178.AWOO02000011_gene3916	1.3e-105	390.6	Actinobacteria	cydC			ko:K06148,ko:K16012,ko:K16014	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1,3.A.1.129			Bacteria	2H79B@201174,COG4987@1,COG4987@2	NA|NA|NA	CO	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MAG.T22.39_01553	1123320.KB889730_gene6071	3.7e-123	448.7	Actinobacteria													Bacteria	2GIWI@201174,COG3850@1,COG3850@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_01554	436229.JOEH01000010_gene5144	1.6e-85	322.4	Streptacidiphilus													Bacteria	2GK4B@201174,2NF0X@228398,COG2197@1,COG2197@2	NA|NA|NA	T	helix_turn_helix, Lux Regulon
MAG.T22.39_01555	1449353.JQMQ01000005_gene2959	4.7e-125	454.5	Streptacidiphilus	pdhA		1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GK3W@201174,2NFED@228398,COG1071@1,COG1071@2	NA|NA|NA	C	Dehydrogenase E1 component
MAG.T22.39_01556	263358.VAB18032_05035	1.3e-131	476.1	Micromonosporales	pdhB	GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS05355,iYO844.BSU14590	Bacteria	2GKFE@201174,4DA2N@85008,COG0022@1,COG0022@2	NA|NA|NA	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MAG.T22.39_01557	469371.Tbis_3330	4.4e-108	398.3	Pseudonocardiales	pdhC		2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GM0D@201174,4DXDX@85010,COG0508@1,COG0508@2	NA|NA|NA	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MAG.T22.39_01558	43759.JNWK01000004_gene1199	8.2e-39	167.5	Actinobacteria													Bacteria	2DMG6@1,2GMQI@201174,32RB5@2	NA|NA|NA	S	MDMPI C-terminal domain
MAG.T22.39_01559	66429.JOFL01000011_gene2649	9.7e-55	220.3	Actinobacteria	mtnU			ko:K11206					ko00000,ko01000				Bacteria	2GMQA@201174,COG0388@1,COG0388@2	NA|NA|NA	E	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MAG.T22.39_01560	222534.KB893736_gene789	2.1e-38	165.2	Actinobacteria													Bacteria	2HAIK@201174,COG2445@1,COG2445@2	NA|NA|NA	S	Protein of unknown function DUF86
MAG.T22.39_01561	1146883.BLASA_4180	6.2e-34	150.2	Actinobacteria				ko:K07075					ko00000				Bacteria	2H5WE@201174,COG1669@1,COG1669@2	NA|NA|NA	S	nucleotidyltransferase activity
MAG.T22.39_01562	1869.MB27_22335	1.1e-37	163.7	Micromonosporales	ddpX		3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651			ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504				Bacteria	2GNX8@201174,4DFJZ@85008,COG3786@1,COG3786@2	NA|NA|NA	S	L,D-transpeptidase catalytic domain
MAG.T22.39_01563	1193181.BN10_1010013	2e-21	109.0	Intrasporangiaceae			2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122		R07459,R07461	RC00043	ko00000,ko00001,ko01000				Bacteria	2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese Homology Domain
MAG.T22.39_01564	420324.KI911992_gene7736	3.8e-25	120.6	Alphaproteobacteria				ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	1MUTY@1224,2U47S@28211,COG0411@1,COG0411@2	NA|NA|NA	E	ATPases associated with a variety of cellular activities
MAG.T22.39_01565	1504319.GM45_6045	2.1e-94	352.1	unclassified Actinobacteria (class)	livF			ko:K01996,ko:K11958	ko02010,ko02024,map02010,map02024	M00237,M00322			ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6			Bacteria	2GKSQ@201174,3UW9F@52018,COG0410@1,COG0410@2	NA|NA|NA	E	ATPases associated with a variety of cellular activities
MAG.T22.39_01566	1416759.AYMR01000018_gene2212	1.6e-27	130.2	Bacteria													Bacteria	COG2852@1,COG2852@2	NA|NA|NA	L	Protein conserved in bacteria
MAG.T22.39_01567	1504319.GM45_6050	4.3e-109	401.7	unclassified Actinobacteria (class)	natB			ko:K01999,ko:K11954	ko02010,ko02024,map02010,map02024	M00237,M00322			ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6			Bacteria	2GM00@201174,3UWIQ@52018,COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems periplasmic
MAG.T22.39_01569	479435.Kfla_4348	1.3e-32	146.0	Propionibacteriales	nusB	GO:0008150,GO:0040007		ko:K03625					ko00000,ko03009,ko03021				Bacteria	2IM3D@201174,4DR4N@85009,COG0781@1,COG0781@2	NA|NA|NA	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MAG.T22.39_01570	1304865.JAGF01000001_gene3192	2.2e-83	315.1	Cellulomonadaceae	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02356					ko00000,ko03012				Bacteria	2GJMS@201174,4F0V8@85016,COG0231@1,COG0231@2	NA|NA|NA	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MAG.T22.39_01571	28444.JODQ01000001_gene2168	2.9e-71	275.8	Streptosporangiales	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271					ko00000,ko01000,ko01002				Bacteria	2GM7D@201174,4EGJ2@85012,COG0006@1,COG0006@2	NA|NA|NA	E	Creatinase/Prolidase N-terminal domain
MAG.T22.39_01572	351607.Acel_1306	2.6e-55	221.5	Frankiales	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000			iIT341.HP1038	Bacteria	2IMBY@201174,4ESSK@85013,COG0757@1,COG0757@2	NA|NA|NA	E	Catalyzes a trans-dehydration via an enolate intermediate
MAG.T22.39_01573	266940.Krad_3013	1.3e-114	419.9	Actinobacteria	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIUZ@201174,COG0337@1,COG0337@2	NA|NA|NA	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MAG.T22.39_01574	543632.JOJL01000026_gene2476	6.8e-42	177.2	Micromonosporales	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71,4.2.3.4	ko:K00891,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000				Bacteria	2GRFW@201174,4DDUR@85008,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MAG.T22.39_01575	1120950.KB892708_gene4302	8.7e-142	510.0	Propionibacteriales	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0976	Bacteria	2GJJN@201174,4DPU4@85009,COG0082@1,COG0082@2	NA|NA|NA	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MAG.T22.39_01578	710111.FraQA3DRAFT_2639	2.8e-37	161.4	Frankiales													Bacteria	2IHRW@201174,31S84@2,4ET6M@85013,arCOG11412@1	NA|NA|NA		
MAG.T22.39_01579	1120934.KB894403_gene347	5.6e-13	80.9	Pseudonocardiales													Bacteria	2DVEK@1,2IG5Q@201174,33VIT@2,4E2J3@85010	NA|NA|NA	S	T4-like virus tail tube protein gp19
MAG.T22.39_01580	446466.Cfla_2260	1.4e-156	559.7	Actinobacteria				ko:K06907					ko00000				Bacteria	2GMJA@201174,COG3497@1,COG3497@2	NA|NA|NA	S	tail sheath protein
MAG.T22.39_01581	1123024.AUII01000001_gene2821	1.1e-12	80.9	Pseudonocardiales				ko:K06976					ko00000				Bacteria	2GMD2@201174,4DXA9@85010,COG3393@1,COG3393@2	NA|NA|NA	S	PFAM Acetyltransferase (GNAT) family
MAG.T22.39_01583	1172181.KB911762_gene7596	4.6e-33	148.7	Actinobacteria													Bacteria	28RC2@1,2GNI9@201174,2ZDRH@2	NA|NA|NA	S	Protein of unknown function (DUF4255)
MAG.T22.39_01585	1120934.KB894404_gene822	9.2e-100	371.3	Pseudonocardiales													Bacteria	2I8CR@201174,4DYJC@85010,COG0464@1,COG0464@2	NA|NA|NA	O	ATPase family associated with various cellular activities (AAA)
MAG.T22.39_01586	667632.KB890176_gene4446	4.2e-19	102.4	Bacteria	corA			ko:K03284					ko00000,ko02000	1.A.35.1,1.A.35.3			Bacteria	COG0598@1,COG0598@2	NA|NA|NA	P	Magnesium transport protein CorA
MAG.T22.39_01588	298654.FraEuI1c_3054	2.7e-69	268.1	Frankiales	cah	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008270,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000				Bacteria	2GM1M@201174,4ESIB@85013,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide
MAG.T22.39_01589	882083.SacmaDRAFT_3101	4.7e-90	337.4	Pseudonocardiales	lsfA		1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	2GM74@201174,4E0A5@85010,COG0450@1,COG0450@2	NA|NA|NA	O	Redoxin
MAG.T22.39_01590	521097.Coch_0028	1.2e-15	89.7	Capnocytophaga													Bacteria	1ERYY@1016,1IF09@117743,335JP@2,4P385@976,arCOG09452@1	NA|NA|NA		
MAG.T22.39_01591	1280954.HPO_08863	1.1e-40	172.9	Alphaproteobacteria													Bacteria	1N7IY@1224,2U993@28211,COG3865@1,COG3865@2	NA|NA|NA	S	3-demethylubiquinone-9 3-methyltransferase
MAG.T22.39_01593	494419.ALPM01000073_gene1483	3.5e-77	295.0	Actinobacteria													Bacteria	2IGYM@201174,COG5524@1,COG5524@2	NA|NA|NA	S	Bacteriorhodopsin-like protein
MAG.T22.39_01594	235985.BBPN01000095_gene2744	6.5e-52	211.1	Streptacidiphilus				ko:K06889					ko00000				Bacteria	2GNUS@201174,2NEQE@228398,COG1073@1,COG1073@2	NA|NA|NA	S	X-Pro dipeptidyl-peptidase (S15 family)
MAG.T22.39_01595	1122611.KB903970_gene2601	7.3e-47	193.7	Streptosporangiales													Bacteria	2GKGF@201174,4ER3N@85012,COG4044@1,COG4044@2	NA|NA|NA	S	Domain of unknown function (DUF1794)
MAG.T22.39_01596	1157637.KB892101_gene2528	5.9e-44	183.7	Actinobacteria				ko:K03711					ko00000,ko03000				Bacteria	2IFHB@201174,COG0735@1,COG0735@2	NA|NA|NA	P	Belongs to the Fur family
MAG.T22.39_01597	1120950.KB892795_gene2294	1.2e-87	330.1	Propionibacteriales			1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	2I4ER@201174,4DX1V@85009,COG0404@1,COG0404@2	NA|NA|NA	E	Glycine cleavage T-protein C-terminal barrel domain
MAG.T22.39_01598	931627.MycrhDRAFT_6107	3.4e-40	171.4	Mycobacteriaceae	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K07560					ko00000,ko01000,ko03016				Bacteria	239CY@1762,2IKVR@201174,COG1490@1,COG1490@2	NA|NA|NA	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MAG.T22.39_01599	1110697.NCAST_25_01730	2.7e-46	193.0	Nocardiaceae				ko:K03294					ko00000	2.A.3.2			Bacteria	2GJ75@201174,4FVXU@85025,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T22.39_01600	1463841.JOIR01000030_gene7567	1e-32	146.4	Actinobacteria	clgR_2	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Bacteria	2IKVI@201174,COG1396@1,COG1396@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_01602	1120950.KB892790_gene2092	1.3e-10	72.4	Propionibacteriales													Bacteria	2DGPE@1,2GXI9@201174,2ZWTE@2,4DSSK@85009	NA|NA|NA	S	Protein of unknown function (DUF2516)
MAG.T22.39_01603	1173023.KE650771_gene578	1.4e-10	74.3	Stigonemataceae	ltrA												Bacteria	1G40Y@1117,1JHJK@1189,COG4292@1,COG4292@2	NA|NA|NA	S	Bacterial low temperature requirement A protein (LtrA)
MAG.T22.39_01604	1380393.JHVP01000009_gene1436	7.1e-98	363.6	Actinobacteria	alaS2	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2I8P6@201174,COG2872@1,COG2872@2	NA|NA|NA	S	Threonyl alanyl tRNA synthetase SAD
MAG.T22.39_01605	1463917.JODC01000011_gene4920	2.2e-105	388.7	Actinobacteria	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	2GK8F@201174,COG0588@1,COG0588@2	NA|NA|NA	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MAG.T22.39_01606	1463858.JOHR01000027_gene128	2.9e-47	194.9	Actinobacteria													Bacteria	2AZ39@1,2GMCY@201174,31R9K@2	NA|NA|NA	S	Putative bacterial sensory transduction regulator
MAG.T22.39_01607	479433.Caci_8224	2.3e-147	528.9	Actinobacteria	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521					ko00000,ko01000				Bacteria	2GJ57@201174,COG0438@1,COG0438@2	NA|NA|NA	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway
MAG.T22.39_01608	1306174.JODP01000006_gene3380	2.3e-55	222.2	Actinobacteria	phoU			ko:K02039					ko00000				Bacteria	2GKAD@201174,COG0704@1,COG0704@2	NA|NA|NA	P	Plays a role in the regulation of phosphate uptake
MAG.T22.39_01609	446471.Xcel_2970	7.3e-90	337.8	Promicromonosporaceae	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07636,ko:K07768,ko:K11383	ko02020,map02020	M00434,M00443,M00505			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	2GJY7@201174,4F3P9@85017,COG5002@1,COG5002@2	NA|NA|NA	T	His Kinase A (phosphoacceptor) domain
MAG.T22.39_01610	1246445.ANAY01000045_gene2278	3.3e-97	361.3	Streptosporangiales													Bacteria	2GKFS@201174,4EFFM@85012,COG0745@1,COG0745@2	NA|NA|NA	T	Transcriptional regulatory protein, C terminal
MAG.T22.39_01612	1048339.KB913029_gene2036	3.2e-70	271.2	Frankiales	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496		ko:K07736					ko00000,ko03000				Bacteria	2GKSU@201174,4ES60@85013,COG1329@1,COG1329@2	NA|NA|NA	K	Transcriptional regulator, CarD family
MAG.T22.39_01613	66377.JOBH01000005_gene2856	5e-64	251.1	Actinobacteria	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12	ko:K00991,ko:K12506,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633,R05637	RC00002,RC00089,RC01440	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNHP@201174,COG1211@1,COG1211@2	NA|NA|NA	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MAG.T22.39_01614	512565.AMIS_77510	6.8e-57	226.9	Micromonosporales	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.1.1.228,2.7.7.60,4.6.1.12	ko:K00554,ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05633,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016			iNJ661.Rv3581c	Bacteria	2II8H@201174,4DDC4@85008,COG0245@1,COG0245@2	NA|NA|NA	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MAG.T22.39_01616	1123322.KB904692_gene4472	4.2e-36	157.5	Actinobacteria													Bacteria	2I31I@201174,COG0748@1,COG0748@2	NA|NA|NA	P	Pyridoxamine 5'-phosphate oxidase
MAG.T22.39_01617	469371.Tbis_0506	1.7e-177	629.0	Pseudonocardiales	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJF2@201174,4DXHD@85010,COG0215@1,COG0215@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
MAG.T22.39_01618	478801.Ksed_03770	2.2e-83	315.8	Dermacoccaceae	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	1ZVRW@145357,2GJMR@201174,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T22.39_01619	1122138.AQUZ01000051_gene7596	7.7e-143	513.8	Propionibacteriales	inaA			ko:K02848	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2GIX0@201174,4DNTH@85009,COG3642@1,COG3642@2	NA|NA|NA	T	Domain of unknown function (DUF4032)
MAG.T22.39_01620	35754.JNYJ01000005_gene5456	1.4e-52	213.0	Micromonosporales				ko:K07010					ko00000,ko01002				Bacteria	2GIV6@201174,4DD3J@85008,COG2071@1,COG2071@2	NA|NA|NA	S	Peptidase C26
MAG.T22.39_01621	443218.AS9A_0822	4e-262	910.6	Mycobacteriaceae	prpE		6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	23529@1762,2GP7N@201174,COG0365@1,COG0365@2	NA|NA|NA	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A
MAG.T22.39_01623	1453503.AU05_17625	3.5e-17	93.2	Gammaproteobacteria	higB			ko:K07334					ko00000,ko02048				Bacteria	1MZ4I@1224,1S9CP@1236,COG3549@1,COG3549@2	NA|NA|NA	S	Plasmid maintenance system killer
MAG.T22.39_01624	1415779.JOMH01000001_gene2557	1e-37	162.5	Xanthomonadales	yddM			ko:K21498					ko00000,ko02048				Bacteria	1N2BD@1224,1S8Z4@1236,1X7T6@135614,COG3093@1,COG3093@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_01625	446468.Ndas_2154	4.3e-98	364.8	Streptosporangiales	yheS_2			ko:K06158,ko:K18230	ko02010,map02010				ko00000,ko00001,ko01504,ko02000,ko03012	3.A.1.120			Bacteria	2GK9S@201174,4EMNZ@85012,COG0488@1,COG0488@2	NA|NA|NA	S	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T22.39_01627	1184609.KILIM_011_00720	1.1e-137	496.1	Dermatophilaceae	pdxS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	4.3.3.6	ko:K06215	ko00750,map00750		R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000				Bacteria	2GK1T@201174,4F60G@85018,COG0214@1,COG0214@2	NA|NA|NA	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MAG.T22.39_01628	1123320.KB889665_gene1379	2e-17	95.5	Actinobacteria				ko:K03744					ko00000				Bacteria	2GK54@201174,COG1704@1,COG1704@2	NA|NA|NA	L	nUDIX hydrolase
MAG.T22.39_01630	253839.SSNG_00156	1.1e-57	229.9	Actinobacteria													Bacteria	2DKWQ@1,2I3CS@201174,30MQE@2	NA|NA|NA	S	Glyoxalase-like domain
MAG.T22.39_01631	1380347.JNII01000007_gene332	1.7e-31	143.7	Frankiales													Bacteria	2ICMJ@201174,4ETKK@85013,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
MAG.T22.39_01632	65497.JODV01000003_gene4650	8.3e-14	84.7	Pseudonocardiales													Bacteria	2AR9G@1,2GN9V@201174,31GJC@2,4E2Q7@85010	NA|NA|NA	S	Domain of unknown function (DUF4192)
MAG.T22.39_01633	1496688.ER33_06255	9.5e-202	709.5	Cyanobium	metY		2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100		R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000			iNJ661.Rv3340	Bacteria	1G4EH@1117,22T9S@167375,COG2873@1,COG2873@2	NA|NA|NA	E	Cys/Met metabolism PLP-dependent enzyme
MAG.T22.39_01634	1496688.ER33_06260	2.4e-148	531.9	Cyanobacteria	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130		R01776	RC00004,RC00041	ko00000,ko00001,ko01000				Bacteria	1G4G5@1117,COG2021@1,COG2021@2	NA|NA|NA	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MAG.T22.39_01635	266940.Krad_3219	2.9e-12	79.3	Actinobacteria													Bacteria	2E4WR@1,2GSGR@201174,32ZQT@2	NA|NA|NA		
MAG.T22.39_01636	1504319.GM45_4930	1.8e-161	575.9	unclassified Actinobacteria (class)	sigA			ko:K03086					ko00000,ko03021				Bacteria	2GK3Z@201174,3UWCE@52018,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAG.T22.39_01637	680646.RMDY18_12590	4.4e-15	87.4	Actinobacteria													Bacteria	2DXS1@1,2HAC0@201174,32V40@2	NA|NA|NA		
MAG.T22.39_01639	479435.Kfla_6452	1.5e-35	156.0	Propionibacteriales				ko:K09167					ko00000				Bacteria	2IR88@201174,4DRVV@85009,COG3402@1,COG3402@2	NA|NA|NA	S	Bacterial PH domain
MAG.T22.39_01640	2055.JNXA01000028_gene134	1.9e-22	112.1	Gordoniaceae				ko:K07006					ko00000				Bacteria	2IQDD@201174,4GEM7@85026,COG3871@1,COG3871@2	NA|NA|NA	S	Pfam:Pyridox_oxidase
MAG.T22.39_01641	101510.RHA1_ro02468	5.8e-88	331.3	Nocardiaceae													Bacteria	2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2	NA|NA|NA	G	Glucose / Sorbosone dehydrogenase
MAG.T22.39_01642	1283287.KB822575_gene535	5.2e-92	344.4	Propionibacteriales	purU		3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670		R00944	RC00026,RC00111	ko00000,ko00001,ko01000				Bacteria	2GM0G@201174,4DP82@85009,COG0788@1,COG0788@2	NA|NA|NA	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
MAG.T22.39_01643	1218352.B597_022890	1.9e-82	312.8	Gammaproteobacteria			1.6.5.5	ko:K00344					ko00000,ko01000				Bacteria	1MXRX@1224,1RPW0@1236,COG0604@1,COG0604@2	NA|NA|NA	C	Zinc-binding dehydrogenase
MAG.T22.39_01644	367299.JOEE01000002_gene2334	6.9e-64	250.8	Intrasporangiaceae													Bacteria	2GP05@201174,4FFK5@85021,COG4221@1,COG4221@2	NA|NA|NA	S	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_01645	1120949.KB903294_gene4123	1e-84	320.5	Micromonosporales			1.1.1.14,1.1.1.287	ko:K00008,ko:K17818	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896,R07143,R07144	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKC7@201174,4DIYT@85008,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T22.39_01646	367299.JOEE01000002_gene2338	1.4e-107	396.4	Intrasporangiaceae	rhaR_1												Bacteria	2HXY3@201174,4FIDY@85021,COG2207@1,COG2207@2	NA|NA|NA	K	helix_turn_helix, arabinose operon control protein
MAG.T22.39_01647	1386089.N865_15765	1.7e-193	682.2	Intrasporangiaceae	smoE			ko:K10227	ko02010,map02010	M00200			ko00000,ko00001,ko00002,ko02000	3.A.1.1.5			Bacteria	2GNI2@201174,4FE6C@85021,COG1653@1,COG1653@2	NA|NA|NA	G	ABC transporter substrate-binding protein
MAG.T22.39_01648	367299.JOEE01000002_gene2336	2.6e-108	398.7	Intrasporangiaceae				ko:K10228,ko:K15771	ko02010,map02010	M00200,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2,3.A.1.1.5			Bacteria	2GM6N@201174,4FGDS@85021,COG1175@1,COG1175@2	NA|NA|NA	G	Sugar ABC transporter permease
MAG.T22.39_01649	529884.Rhola_00001820	2.8e-98	365.2	Microbacteriaceae	smoG			ko:K10229	ko02010,map02010	M00200			ko00000,ko00001,ko00002,ko02000	3.A.1.1.5			Bacteria	2GN84@201174,4FM88@85023,COG0395@1,COG0395@2	NA|NA|NA	G	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01650	479432.Sros_3496	2.4e-172	612.1	Streptosporangiales	mtlK	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.17,1.1.1.57,1.1.1.67	ko:K00009,ko:K00040,ko:K00045	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00061	R00868,R02454,R02703	RC00085	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Bacteria	2GJ4F@201174,4EJA3@85012,COG0246@1,COG0246@2	NA|NA|NA	C	Mannitol dehydrogenase Rossmann domain
MAG.T22.39_01651	390989.JOEG01000014_gene3042	1.2e-95	356.7	Micromonosporales	gutB_1		1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKC7@201174,4DIYT@85008,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
MAG.T22.39_01652	596328.HMPREF0578_1016	6.8e-11	73.6	Actinobacteria													Bacteria	2IRY1@201174,4D7HA@85005,COG2361@1,COG2361@2	NA|NA|NA	S	Protein of unknown function DUF86
MAG.T22.39_01653	882083.SacmaDRAFT_1891	8.9e-23	113.6	Pseudonocardiales	MA20_07360			ko:K07075,ko:K15546					ko00000,ko03000				Bacteria	2HGH4@201174,4EDDK@85010,COG1396@1,COG1396@2,COG1669@1,COG1669@2	NA|NA|NA	K	Nucleotidyltransferase domain
MAG.T22.39_01654	232348.ADXL01000055_gene2007	2e-10	72.4	Bacteria													Bacteria	2EKQ3@1,33EDU@2	NA|NA|NA		
MAG.T22.39_01655	1218084.BBJK01000031_gene2931	1.2e-86	326.6	Burkholderiaceae			5.1.3.30,5.1.3.31	ko:K18910			R10817,R10818	RC03111,RC03283	ko00000,ko01000				Bacteria	1K3MT@119060,1MV2C@1224,2VP01@28216,COG1082@1,COG1082@2	NA|NA|NA	G	Xylose isomerase-like TIM barrel
MAG.T22.39_01656	1382306.JNIM01000001_gene2182	9.1e-75	287.0	Bacteria			3.6.3.17	ko:K10545	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4			Bacteria	COG1129@1,COG1129@2	NA|NA|NA	G	ABC transporter
MAG.T22.39_01657	749414.SBI_01790	7.3e-77	294.3	Actinobacteria				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2GJDW@201174,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01658	1382306.JNIM01000001_gene2184	4.6e-69	268.5	Chloroflexi				ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	2G79U@200795,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T22.39_01659	1246448.ANAZ01000021_gene1883	7.4e-71	274.6	Streptosporangiales			2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ2S@201174,4EFQ1@85012,COG1940@1,COG1940@2,COG3355@1,COG3355@2	NA|NA|NA	GK	ROK family
MAG.T22.39_01660	66373.JOFQ01000031_gene3980	3.4e-43	181.8	Actinobacteria	yieH		3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000				Bacteria	2GMIQ@201174,COG0637@1,COG0637@2	NA|NA|NA	Q	hydrolase
MAG.T22.39_01661	1229780.BN381_10161	2.1e-15	88.2	Actinobacteria				ko:K06218					ko00000,ko02048				Bacteria	2IRES@201174,COG2026@1,COG2026@2	NA|NA|NA	DJ	ParE toxin of type II toxin-antitoxin system, parDE
MAG.T22.39_01662	1229780.BN381_10160	4.1e-20	104.0	Actinobacteria				ko:K19159					ko00000,ko02048				Bacteria	2IRS2@201174,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T22.39_01663	1193181.BN10_680058	3.8e-40	171.4	Intrasporangiaceae	ymdB												Bacteria	2IFEC@201174,4FGQM@85021,COG2110@1,COG2110@2	NA|NA|NA	S	phosphatase homologous to the C-terminal domain of histone macroH2A1
MAG.T22.39_01664	644548.SCNU_20097	2.4e-07	63.2	Actinobacteria													Bacteria	2IPNU@201174,COG1403@1,COG1403@2	NA|NA|NA	V	HNH endonuclease
MAG.T22.39_01665	1232436.CAPF01000061_gene1290	1.9e-33	148.3	Coriobacteriia	higA			ko:K21498					ko00000,ko02048				Bacteria	2IR2S@201174,4CWBD@84998,COG3093@1,COG3093@2	NA|NA|NA	K	addiction module antidote protein, HigA
MAG.T22.39_01666	28444.JODQ01000005_gene1364	1.8e-77	295.8	Streptosporangiales	glnQ		3.6.3.21	ko:K02028		M00236			ko00000,ko00002,ko01000,ko02000	3.A.1.3			Bacteria	2GIZW@201174,4EHXC@85012,COG1126@1,COG1126@2	NA|NA|NA	E	ATPases associated with a variety of cellular activities
MAG.T22.39_01667	469371.Tbis_3556	9.4e-89	333.6	Pseudonocardiales				ko:K02029		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	2GM0I@201174,4DY5M@85010,COG0765@1,COG0765@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01668	1122609.AUGT01000018_gene143	1.5e-81	309.7	Propionibacteriales				ko:K02029,ko:K02030		M00236			ko00000,ko00002,ko02000	3.A.1.3			Bacteria	2GN3G@201174,4DNI8@85009,COG0834@1,COG0834@2	NA|NA|NA	ET	Bacterial periplasmic substrate-binding proteins
MAG.T22.39_01669	1122994.AUFR01000007_gene999	1.4e-12	79.7	Actinobacteria													Bacteria	2DQQV@1,2GW4Q@201174,3385P@2	NA|NA|NA		
MAG.T22.39_01670	1476876.JOJO01000020_gene185	2.1e-38	166.0	Actinobacteria	dnaQ		2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2ID1T@201174,COG0847@1,COG0847@2	NA|NA|NA	L	Exonuclease
MAG.T22.39_01671	1121106.JQKB01000046_gene3083	4.6e-14	84.3	Rhodospirillales	vapC												Bacteria	1N96B@1224,2JY9R@204441,2UDE1@28211,COG4113@1,COG4113@2	NA|NA|NA	S	PIN domain
MAG.T22.39_01672	1304865.JAGF01000001_gene1136	2.5e-08	64.7	Bacteria													Bacteria	COG4118@1,COG4118@2	NA|NA|NA	D	positive regulation of growth
MAG.T22.39_01674	105559.Nwat_2431	2.5e-17	94.7	Gammaproteobacteria				ko:K09803					ko00000				Bacteria	1MZKJ@1224,1S984@1236,COG2929@1,COG2929@2	NA|NA|NA	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system
MAG.T22.39_01675	1028801.RG1141_CH25590	4.5e-22	110.2	Rhizobiaceae													Bacteria	1N7A9@1224,2E3TC@1,2UFK1@28211,32YQV@2,4BGSE@82115	NA|NA|NA	S	copG family
MAG.T22.39_01676	446469.Sked_15190	8.3e-13	80.1	Actinobacteria													Bacteria	2CKUX@1,2IQH0@201174,32SD2@2	NA|NA|NA	S	Mycobacterial 4 TMS phage holin, superfamily IV
MAG.T22.39_01677	529884.Rhola_00003090	4.5e-29	134.8	Microbacteriaceae				ko:K05595					ko00000,ko02000	2.A.95.1			Bacteria	2GMCM@201174,4FT0S@85023,COG2095@1,COG2095@2	NA|NA|NA	U	MarC family integral membrane protein
MAG.T22.39_01678	525909.Afer_1621	2.6e-12	78.2	Bacteria													Bacteria	COG4118@1,COG4118@2	NA|NA|NA	D	positive regulation of growth
MAG.T22.39_01679	105425.BBPL01000001_gene6347	3.9e-203	714.1	Streptacidiphilus	ccrA2	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043880,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200		R09738	RC00076	ko00000,ko00001,ko01000				Bacteria	2GKFF@201174,2NEDY@228398,COG0604@1,COG0604@2	NA|NA|NA	C	Alcohol dehydrogenase GroES-like domain
MAG.T22.39_01680	1869.MB27_13665	7.4e-47	193.4	Micromonosporales	mce		5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000				Bacteria	2IIPR@201174,4DCP3@85008,COG0346@1,COG0346@2	NA|NA|NA	E	glyoxalase bleomycin resistance protein dioxygenase
MAG.T22.39_01682	1298863.AUEP01000005_gene2348	2.5e-75	288.9	Propionibacteriales	recB			ko:K07465					ko00000				Bacteria	2GJC5@201174,4DP6M@85009,COG2887@1,COG2887@2	NA|NA|NA	L	Protein of unknown function (DUF2800)
MAG.T22.39_01683	469371.Tbis_1839	1.7e-88	332.8	Pseudonocardiales	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.219,2.1.1.220	ko:K07442					ko00000,ko01000,ko03016				Bacteria	2GJPD@201174,4DX8Q@85010,COG2519@1,COG2519@2	NA|NA|NA	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MAG.T22.39_01684	222534.KB893705_gene5867	1.8e-229	802.0	Frankiales	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369		ko:K13527	ko03050,map03050	M00342			ko00000,ko00001,ko00002,ko03051				Bacteria	2GMR1@201174,4ERPJ@85013,COG1222@1,COG1222@2	NA|NA|NA	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis
MAG.T22.39_01685	446468.Ndas_1488	2.7e-184	651.7	Streptosporangiales	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	2GJGI@201174,4EGNP@85012,COG4122@1,COG4122@2	NA|NA|NA	S	Pup-ligase protein
MAG.T22.39_01687	1894.JOER01000056_gene3343	5.2e-84	317.8	Actinobacteria	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	2GJ60@201174,COG0638@1,COG0638@2	NA|NA|NA	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
MAG.T22.39_01688	1380370.JIBA01000013_gene1447	2.9e-77	295.0	Intrasporangiaceae	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343			ko00000,ko00001,ko00002,ko01000,ko01002,ko03051				Bacteria	2GKZ1@201174,4FFJS@85021,COG0638@1,COG0638@2	NA|NA|NA	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation
MAG.T22.39_01689	1122611.KB904018_gene6987	1.2e-207	729.2	Streptosporangiales	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571		M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051				Bacteria	2GMC6@201174,4EGN1@85012,COG0638@1,COG0638@2	NA|NA|NA	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAG.T22.39_01690	1120954.ATXE01000002_gene1217	3.3e-24	118.6	Propionibacteriales	fkbP		5.2.1.8	ko:K01802					ko00000,ko01000				Bacteria	2IHQC@201174,4DQUT@85009,COG0545@1,COG0545@2	NA|NA|NA	O	Peptidyl-prolyl cis-trans
MAG.T22.39_01691	1110697.NCAST_13_02250	2.1e-47	194.9	Nocardiaceae	fkb		5.2.1.8	ko:K01802,ko:K03772					ko00000,ko01000,ko03110				Bacteria	2IHQC@201174,4G16T@85025,COG0545@1,COG0545@2	NA|NA|NA	O	Peptidyl-prolyl cis-trans
MAG.T22.39_01692	28444.JODQ01000004_gene6295	2.1e-41	176.4	Streptosporangiales	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K13572,ko:K13573					ko00000,ko03051				Bacteria	2GM46@201174,4EFRP@85012,COG2378@1,COG2378@2	NA|NA|NA	K	WYL domain
MAG.T22.39_01693	1206732.BAGD01000076_gene3095	3.9e-43	182.2	Nocardiaceae	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944		ko:K13573					ko00000,ko03051				Bacteria	2GMAU@201174,4FV30@85025,COG2378@1,COG2378@2	NA|NA|NA	K	WYL domain
MAG.T22.39_01694	106370.Francci3_2607	5e-12	77.0	Frankiales	tatA			ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2GQQX@201174,4ETM8@85013,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MAG.T22.39_01695	1504319.GM45_0890	3.5e-72	278.5	unclassified Actinobacteria (class)	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	2GJK8@201174,3UWSI@52018,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
MAG.T22.39_01696	67352.JODS01000002_gene1199	3.3e-44	185.7	Actinobacteria	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110		R02240	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GK3P@201174,COG1597@1,COG1597@2	NA|NA|NA	I	Diacylglycerol kinase
MAG.T22.39_01697	1123322.KB904647_gene1742	1.1e-284	986.1	Actinobacteria	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K03727					ko00000,ko01000				Bacteria	2GJEX@201174,COG4581@1,COG4581@2	NA|NA|NA	L	DEAD DEAH box helicase
MAG.T22.39_01698	105422.BBPM01000011_gene7198	2.1e-73	282.7	Streptacidiphilus	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	2GKTZ@201174,2NEBY@228398,COG0258@1,COG0258@2	NA|NA|NA	L	Helix-hairpin-helix class 2 (Pol1 family) motifs
MAG.T22.39_01699	469371.Tbis_1815	1.7e-108	399.4	Pseudonocardiales	pepE		3.4.13.9	ko:K01271,ko:K01274					ko00000,ko01000,ko01002				Bacteria	2GM7D@201174,4DXYB@85010,COG0006@1,COG0006@2	NA|NA|NA	E	Belongs to the peptidase M24B family
MAG.T22.39_01700	981369.JQMJ01000004_gene3793	1.2e-137	496.9	Streptacidiphilus	ytcJ												Bacteria	2GJVW@201174,2NF2S@228398,COG1574@1,COG1574@2	NA|NA|NA	S	Amidohydrolase family
MAG.T22.39_01701	500153.JOEK01000010_gene4715	1.5e-89	337.0	Actinobacteria	lnt			ko:K03820					ko00000,ko01000		GT2		Bacteria	2GJ9F@201174,COG0815@1,COG0815@2	NA|NA|NA	M	Transfers the fatty acyl group on membrane lipoproteins
MAG.T22.39_01702	68170.KL590472_gene6485	5.1e-94	350.9	Pseudonocardiales	dpm1		2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100		R01009	RC00005	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	2I2FA@201174,4DYYD@85010,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
MAG.T22.39_01704	266940.Krad_1892	2.4e-27	128.3	Actinobacteria	rbpA	GO:0001000,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0043167,GO:0043169,GO:0043175,GO:0045893,GO:0045935,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	2CNY9@1,2IMK6@201174,32SI2@2	NA|NA|NA	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters
MAG.T22.39_01705	935839.JAGJ01000003_gene1540	6.4e-68	264.6	Promicromonosporaceae				ko:K04763					ko00000,ko03036				Bacteria	2IN3W@201174,4F3HT@85017,COG4974@1,COG4974@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
MAG.T22.39_01706	58123.JOFJ01000007_gene704	0.0	1223.8	Streptosporangiales	gcvP	GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3318	Bacteria	2GJ11@201174,4EI8D@85012,COG0403@1,COG0403@2,COG1003@1,COG1003@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAG.T22.39_01707	593907.Celgi_1709	1.2e-63	249.6	Cellulomonadaceae	merR2												Bacteria	2GM67@201174,4F16V@85016,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T22.39_01708	1449346.JQMO01000003_gene3002	1.3e-50	206.1	Kitasatospora		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944		ko:K03617,ko:K08999					ko00000				Bacteria	2GN26@201174,2M26I@2063,COG1259@1,COG1259@2	NA|NA|NA	S	Bifunctional nuclease
MAG.T22.39_01709	345341.KUTG_01357	1.1e-47	196.8	Pseudonocardiales	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464											Bacteria	2HBV6@201174,4DY01@85010,COG0789@1,COG0789@2	NA|NA|NA	K	PFAM MerR family regulatory protein
MAG.T22.39_01710	351607.Acel_1226	3.3e-35	154.8	Frankiales													Bacteria	2GK99@201174,4ESK3@85013,COG1716@1,COG1716@2	NA|NA|NA	T	FHA domain containing protein
MAG.T22.39_01711	266940.Krad_3097	2e-35	155.2	Actinobacteria	gcvH			ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002			iNJ661.Rv1826	Bacteria	2IKN2@201174,COG0509@1,COG0509@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
MAG.T22.39_01712	365528.KB891102_gene4370	1.9e-45	189.1	Frankiales	pgsA	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	2GM3F@201174,4ESIK@85013,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAG.T22.39_01714	1463921.JODF01000003_gene2441	1.6e-41	176.4	Actinobacteria				ko:K07090					ko00000				Bacteria	2GJCC@201174,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
MAG.T22.39_01715	765123.HMPREF9621_01162	7.5e-69	267.3	Propionibacteriales	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3			Bacteria	2GIXX@201174,4DNDT@85009,COG1119@1,COG1119@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T22.39_01716	313589.JNB_03230	3.5e-104	385.2	Intrasporangiaceae	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009			iNJ661.Rv3042c	Bacteria	2GJDH@201174,4FFIF@85021,COG0560@1,COG0560@2,COG3830@1,COG3830@2	NA|NA|NA	E	phosphoserine phosphatase
MAG.T22.39_01717	1246459.KB898378_gene3452	3.7e-19	101.7	Rhizobiaceae	sixA			ko:K08296					ko00000,ko01000				Bacteria	1N0FX@1224,2UBYD@28211,4BF34@82115,COG2062@1,COG2062@2	NA|NA|NA	T	phosphohistidine phosphatase
MAG.T22.39_01718	1122933.JNIY01000005_gene1490	7.4e-106	390.2	Cellulomonadaceae	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	2GJ65@201174,4F0ZV@85016,COG0623@1,COG0623@2	NA|NA|NA	I	Enoyl- acyl-carrier-protein reductase NADH
MAG.T22.39_01719	1289387.AUKW01000005_gene2020	4.8e-70	271.2	Actinobacteria													Bacteria	2GK6C@201174,COG1028@1,COG1028@2	NA|NA|NA	IQ	reductase
MAG.T22.39_01720	1150399.AQYK01000001_gene15	7.5e-14	84.3	Microbacteriaceae													Bacteria	2IQG2@201174,4FPAK@85023,COG3548@1,COG3548@2	NA|NA|NA	S	Protein of unknown function (DUF1211)
MAG.T22.39_01721	351607.Acel_1147	2.7e-18	97.4	Frankiales				ko:K09165					ko00000				Bacteria	2IQ6Z@201174,4ETCR@85013,COG3360@1,COG3360@2	NA|NA|NA	S	Dodecin
MAG.T22.39_01722	1122933.JNIY01000005_gene1488	1.3e-16	92.4	Cellulomonadaceae													Bacteria	2E3SR@1,2GQKG@201174,32YQ8@2,4F1HM@85016	NA|NA|NA		
MAG.T22.39_01723	1713.JOFV01000013_gene951	1.7e-20	106.3	Cellulomonadaceae	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944		ko:K14998					ko00000,ko03029	3.D.4.8			Bacteria	2GR90@201174,4F17F@85016,COG3346@1,COG3346@2	NA|NA|NA	S	SURF1 family
MAG.T22.39_01724	1122138.AQUZ01000001_gene1538	3.9e-209	734.6	Propionibacteriales	msbA9			ko:K06147					ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21			Bacteria	2GITR@201174,4DN7W@85009,COG1132@1,COG1132@2	NA|NA|NA	V	ABC transporter transmembrane region
MAG.T22.39_01725	1184607.AUCHE_05_03470	4.4e-29	135.2	Dermatophilaceae	echA												Bacteria	2GKC4@201174,4F6Y0@85018,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase/isomerase
MAG.T22.39_01726	1304865.JAGF01000001_gene3629	1.3e-189	669.5	Cellulomonadaceae	ybiT												Bacteria	2GKQ4@201174,4F0IQ@85016,COG0488@1,COG0488@2	NA|NA|NA	S	Dynein light intermediate chain (DLIC)
MAG.T22.39_01727	1048339.KB913029_gene4333	8.4e-43	179.5	Frankiales	yitW			ko:K02612	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001				Bacteria	2IKUH@201174,4ESWH@85013,COG2151@1,COG2151@2	NA|NA|NA	S	Pfam:DUF59
MAG.T22.39_01728	1894.JOER01000072_gene7866	6e-47	193.7	Actinobacteria	iscU			ko:K04488					ko00000				Bacteria	2IHY9@201174,COG0822@1,COG0822@2	NA|NA|NA	C	Suf system fes assembly protein, nifu family
MAG.T22.39_01729	446468.Ndas_2959	5.2e-160	570.9	Streptosporangiales	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000				Bacteria	2GIVK@201174,4EHYF@85012,COG0520@1,COG0520@2	NA|NA|NA	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MAG.T22.39_01730	164757.Mjls_2474	4.5e-111	407.5	Mycobacteriaceae	sufC			ko:K09013					ko00000,ko02000				Bacteria	233X3@1762,2GKB7@201174,COG0396@1,COG0396@2	NA|NA|NA	O	FeS assembly ATPase SufC
MAG.T22.39_01731	1463845.JOIG01000007_gene597	5.5e-27	127.1	Actinobacteria	hcaC			ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002				Bacteria	2IQK7@201174,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske 2Fe-2S
MAG.T22.39_01732	1122622.ATWJ01000010_gene1340	4.4e-86	325.1	Intrasporangiaceae	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136		ko:K09015					ko00000			iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	Bacteria	2GJNV@201174,4FF87@85021,COG0719@1,COG0719@2	NA|NA|NA	O	ABC transporter (Permease)
MAG.T22.39_01733	1048339.KB913029_gene4338	3.5e-197	694.1	Frankiales	sufB			ko:K07033,ko:K09014					ko00000				Bacteria	2GKCZ@201174,4ERKY@85013,COG0719@1,COG0719@2	NA|NA|NA	O	TIGRFAM FeS assembly protein SufB
MAG.T22.39_01734	1121946.AUAX01000014_gene1079	1.7e-36	159.5	Micromonosporales	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	2GQ3G@201174,4D8ZN@85008,COG0742@1,COG0742@2	NA|NA|NA	L	Methyltransferase
MAG.T22.39_01735	28042.GU90_17910	4.7e-201	708.0	Pseudonocardiales	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GKA3@201174,4DX3U@85010,COG1200@1,COG1200@2	NA|NA|NA	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MAG.T22.39_01736	1123320.KB889676_gene2888	5.5e-103	381.7	Actinobacteria	dak3		2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K07030	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01059	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKII@201174,COG1461@1,COG1461@2	NA|NA|NA	S	Dihydroxyacetone kinase
MAG.T22.39_01737	585531.HMPREF0063_11206	3.7e-78	298.5	Propionibacteriales	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2977c,iYO844.BSU05900	Bacteria	2GP6E@201174,4DNV9@85009,COG0611@1,COG0611@2	NA|NA|NA	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MAG.T22.39_01738	479431.Namu_1487	5.4e-23	113.2	Frankiales													Bacteria	2IQ4Z@201174,4ET4W@85013,COG1522@1,COG1522@2	NA|NA|NA	K	PFAM regulatory protein AsnC Lrp family
MAG.T22.39_01739	1120950.KB892741_gene2701	7.6e-21	107.1	Propionibacteriales													Bacteria	2CQFE@1,2GRVK@201174,32SM3@2,4DS6W@85009	NA|NA|NA	S	Protein of unknown function (DUF3515)
MAG.T22.39_01740	1348663.KCH_11920	9e-27	127.1	Kitasatospora													Bacteria	2GX8K@201174,2M4HA@2063,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
MAG.T22.39_01741	1370120.AUWR01000055_gene3109	1.5e-85	323.2	Mycobacteriaceae	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Bacteria	2334U@1762,2GITC@201174,COG1181@1,COG1181@2	NA|NA|NA	F	Belongs to the D-alanine--D-alanine ligase family
MAG.T22.39_01742	110319.CF8_2890	1.2e-83	317.0	Propionibacteriales	metB		2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMD8@201174,4DPBS@85009,COG0626@1,COG0626@2	NA|NA|NA	E	Cys/Met metabolism PLP-dependent enzyme
MAG.T22.39_01743	1463934.JOCF01000037_gene2137	1.5e-109	402.9	Actinobacteria	gpsA		1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110		R00842,R00844	RC00029	ko00000,ko00001,ko01000				Bacteria	2GJSD@201174,COG0240@1,COG0240@2	NA|NA|NA	I	Glycerol-3-phosphate dehydrogenase
MAG.T22.39_01744	1123320.KB889676_gene2895	2e-71	275.8	Actinobacteria	plsC2												Bacteria	2GKVA@201174,COG0204@1,COG0204@2	NA|NA|NA	I	Acyltransferase
MAG.T22.39_01745	369723.Strop_1264	7e-20	104.4	Micromonosporales	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2HJNU@201174,4DDTA@85008,COG1920@1,COG1920@2	NA|NA|NA	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor
MAG.T22.39_01746	1056816.JAFQ01000004_gene7086	1.1e-20	106.3	Nocardiaceae	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	2GV0M@201174,4FUU2@85025,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MAG.T22.39_01747	1451189.CFAL_06760	3.3e-77	294.7	Corynebacteriaceae	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv2987c	Bacteria	22K0I@1653,2GJ8Z@201174,COG0066@1,COG0066@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T22.39_01748	1157637.KB892120_gene365	2e-221	775.0	Actinobacteria	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531	Bacteria	2GKT7@201174,COG0065@1,COG0065@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAG.T22.39_01751	1463887.KL589967_gene6559	5.8e-96	357.5	Actinobacteria	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iNJ661.Rv2992c	Bacteria	2GJJS@201174,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAG.T22.39_01752	1449346.JQMO01000003_gene3926	2.3e-30	138.7	Kitasatospora	nuoL	GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GIT4@201174,2M17A@2063,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
MAG.T22.39_01753	479433.Caci_7679	7.8e-155	553.9	Actinobacteria	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iSDY_1059.SDY_2473	Bacteria	2GKBN@201174,COG1008@1,COG1008@2	NA|NA|NA	C	proton-translocating NADH-quinone oxidoreductase, chain M
MAG.T22.39_01754	1504319.GM45_4185	8.1e-160	570.5	unclassified Actinobacteria (class)	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GMGX@201174,3UWFY@52018,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_01755	1048339.KB913029_gene2590	7.1e-117	427.2	Frankiales	hepS	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110		R09247	RC00279	ko00000,ko00001,ko01000,ko01006				Bacteria	2GMB4@201174,4ERU8@85013,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
MAG.T22.39_01756	477641.MODMU_0774	2.5e-79	302.4	Frankiales	rarD			ko:K05786					ko00000,ko02000	2.A.7.7			Bacteria	2GKCP@201174,4ESFQ@85013,COG2962@1,COG2962@2	NA|NA|NA	S	EamA-like transporter family
MAG.T22.39_01757	471852.Tcur_4392	2.3e-142	511.9	Streptosporangiales	korB		1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GMI5@201174,4EH97@85012,COG1013@1,COG1013@2	NA|NA|NA	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
MAG.T22.39_01758	351607.Acel_0284	5.1e-273	946.8	Frankiales	korA		1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GKXV@201174,4ERWB@85013,COG0674@1,COG0674@2,COG1014@1,COG1014@2	NA|NA|NA	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase
MAG.T22.39_01760	469371.Tbis_0317	4.3e-16	91.7	Pseudonocardiales	nuoC2		1.6.5.3	ko:K00332,ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GNVP@201174,4E2UB@85010,COG0852@1,COG0852@2	NA|NA|NA	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit
MAG.T22.39_01761	1170318.PALO_01490	9.9e-28	129.4	Actinobacteria	nuoI		1.6.5.3	ko:K00338,ko:K03615,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GPSS@201174,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAG.T22.39_01763	585531.HMPREF0063_12562	1.3e-63	249.2	Propionibacteriales	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K09767					ko00000				Bacteria	2IFIU@201174,4DQT9@85009,COG1666@1,COG1666@2	NA|NA|NA	S	Belongs to the UPF0234 family
MAG.T22.39_01766	1121017.AUFG01000026_gene246	1.5e-34	154.1	Intrasporangiaceae	capB		6.3.2.12,6.3.2.17	ko:K01932,ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2475	Bacteria	2GKSV@201174,4FI9Q@85021,COG0285@1,COG0285@2	NA|NA|NA	H	Mur ligase middle domain
MAG.T22.39_01767	1313172.YM304_13700	3.7e-14	86.3	Bacteria	capC			ko:K22116					ko00000				Bacteria	2CGV9@1,333YX@2	NA|NA|NA	S	Capsule biosynthesis CapC
MAG.T22.39_01768	28444.JODQ01000001_gene2654	4.5e-81	308.1	Streptosporangiales													Bacteria	2GIYQ@201174,4EIJ9@85012,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_01771	1385518.N798_05690	6.7e-20	102.4	Intrasporangiaceae	rpmG			ko:K02913	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQFG@201174,4FHNB@85021,COG0267@1,COG0267@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL33 family
MAG.T22.39_01772	1380393.JHVP01000002_gene1890	1.4e-40	172.6	Frankiales													Bacteria	2GMVC@201174,4ET6X@85013,COG2030@1,COG2030@2	NA|NA|NA	I	Belongs to the UPF0336 family
MAG.T22.39_01773	1114959.SZMC14600_13249	6.6e-40	170.2	Pseudonocardiales	hadB												Bacteria	2IFCJ@201174,4E4UR@85010,COG2030@1,COG2030@2	NA|NA|NA	I	dehydratase
MAG.T22.39_01774	1504319.GM45_2735	2.1e-39	169.5	Actinobacteria			6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2IJEY@201174,COG1216@1,COG1216@2	NA|NA|NA	J	cysteine-tRNA ligase activity
MAG.T22.39_01775	1032480.MLP_10560	1.4e-83	316.6	Propionibacteriales	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100		R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011			iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845	Bacteria	2GIV2@201174,4DNF7@85009,COG0812@1,COG0812@2	NA|NA|NA	M	Cell wall formation
MAG.T22.39_01776	1996.JOFO01000009_gene1601	5.5e-180	637.1	Streptosporangiales	aspC												Bacteria	2GJ7R@201174,4EGQ9@85012,COG0436@1,COG0436@2	NA|NA|NA	E	DegT/DnrJ/EryC1/StrS aminotransferase family
MAG.T22.39_01778	1068978.AMETH_0623	1e-12	79.3	Pseudonocardiales	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	2GQFP@201174,4E5GS@85010,COG0690@1,COG0690@2	NA|NA|NA	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MAG.T22.39_01779	1048339.KB913029_gene2728	4.8e-72	278.1	Frankiales	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601					ko00000,ko03009,ko03021				Bacteria	2GJFW@201174,4ES8J@85013,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination
MAG.T22.39_01780	653386.HMPREF0975_01238	8.2e-62	243.0	Actinobacteria	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02867	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IFCK@201174,4D5J5@85005,COG0080@1,COG0080@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MAG.T22.39_01781	1089455.MOPEL_098_00060	3e-101	374.8	Dermatophilaceae	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02863	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GM51@201174,4F6JF@85018,COG0081@1,COG0081@2	NA|NA|NA	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MAG.T22.39_01782	1394178.AWOO02000016_gene6864	1.2e-69	270.0	Streptosporangiales				ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMEE@201174,4EIB3@85012,COG0411@1,COG0411@2	NA|NA|NA	E	Branched-chain amino acid ATP-binding cassette transporter
MAG.T22.39_01783	1157637.KB892092_gene6928	2.2e-64	252.3	Actinobacteria				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GKSQ@201174,COG0410@1,COG0410@2	NA|NA|NA	E	ABC transporter
MAG.T22.39_01784	1157637.KB892092_gene6927	4.4e-62	245.0	Actinobacteria				ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2HDZ9@201174,COG0559@1,COG0559@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01785	1122939.ATUD01000004_gene3833	6.7e-41	175.3	Rubrobacteria				ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMGD@201174,4CQPV@84995,COG4177@1,COG4177@2	NA|NA|NA	E	Branched-chain amino acid transport system / permease component
MAG.T22.39_01786	512565.AMIS_73820	7e-64	251.5	Micromonosporales	ilvJ			ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMCF@201174,4D8YQ@85008,COG0683@1,COG0683@2	NA|NA|NA	E	ABC-type branched-chain amino acid transport systems, periplasmic component
MAG.T22.39_01787	479433.Caci_0915	7.6e-57	227.3	Actinobacteria	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02864,ko:K02935	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GM0V@201174,COG0244@1,COG0244@2	NA|NA|NA	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MAG.T22.39_01788	367299.JOEE01000001_gene2149	7.3e-41	173.3	Intrasporangiaceae	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K02935	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IKNW@201174,4FGN6@85021,COG0222@1,COG0222@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MAG.T22.39_01789	570268.ANBB01000033_gene2144	0.0	1848.9	Streptosporangiales	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2GJ81@201174,4EFYQ@85012,COG0085@1,COG0085@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T22.39_01790	479435.Kfla_4744	7.8e-58	230.3	Propionibacteriales	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02357					ko00000,ko03012,ko03029				Bacteria	2GK4M@201174,4DNDW@85009,COG0264@1,COG0264@2	NA|NA|NA	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MAG.T22.39_01791	1348663.KCH_52500	1.1e-99	369.8	Kitasatospora	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100		R00158	RC00002	ko00000,ko00001,ko01000			iSB619.SA_RS06240	Bacteria	2GKWQ@201174,2M143@2063,COG0528@1,COG0528@2	NA|NA|NA	F	Amino acid kinase family
MAG.T22.39_01792	1048339.KB913029_gene3531	2.3e-72	278.5	Frankiales	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02838					ko00000,ko03012				Bacteria	2GJ9J@201174,4ESC9@85013,COG0233@1,COG0233@2	NA|NA|NA	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MAG.T22.39_01793	479435.Kfla_4741	2.1e-69	269.2	Propionibacteriales	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNWK@201174,4DQ6M@85009,COG4589@1,COG4589@2	NA|NA|NA	S	Belongs to the CDS family
MAG.T22.39_01794	469371.Tbis_1000	2.1e-146	525.4	Pseudonocardiales	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Bacteria	2GJ48@201174,4DXDS@85010,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MAG.T22.39_01795	1120949.KB903330_gene9153	1.4e-55	223.0	Micromonosporales													Bacteria	2GKH7@201174,4DC2S@85008,COG1802@1,COG1802@2	NA|NA|NA	K	FCD
MAG.T22.39_01796	1298864.AUEQ01000001_gene4738	4.4e-118	431.4	Mycobacteriaceae													Bacteria	232AA@1762,2GIU7@201174,COG1804@1,COG1804@2	NA|NA|NA	C	acyl-CoA transferases carnitine dehydratase
MAG.T22.39_01797	1449069.JMLO01000011_gene2478	1.4e-159	569.3	Nocardiaceae	gcdH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIX8@201174,4FXI1@85025,COG1960@1,COG1960@2	NA|NA|NA	I	acyl-CoA dehydrogenase
MAG.T22.39_01798	1123320.KB889675_gene4065	1.1e-141	510.0	Actinobacteria													Bacteria	2GJQ9@201174,COG0665@1,COG0665@2	NA|NA|NA	E	FAD dependent oxidoreductase
MAG.T22.39_01799	479433.Caci_1550	2.7e-51	208.8	Actinobacteria				ko:K05558,ko:K07005					ko00000				Bacteria	2GJ76@201174,COG3467@1,COG3467@2	NA|NA|NA	J	Flavin-nucleotide-binding protein
MAG.T22.39_01800	1172188.KB911821_gene1371	1.6e-207	728.8	Intrasporangiaceae	bioA												Bacteria	2GKF6@201174,4FE6A@85021,COG0161@1,COG0161@2	NA|NA|NA	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T22.39_01801	1463934.JOCF01000037_gene2043	1.9e-56	225.3	Actinobacteria	asnC			ko:K03718					ko00000,ko03000				Bacteria	2GP1P@201174,COG1522@1,COG1522@2	NA|NA|NA	K	AsnC family
MAG.T22.39_01802	526225.Gobs_1721	3.5e-213	747.7	Frankiales			1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,4ERRA@85013,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_01803	2045.KR76_05745	3.9e-40	172.2	Propionibacteriales													Bacteria	2IE46@201174,4DUBS@85009,COG0583@1,COG0583@2	NA|NA|NA	K	Bacterial regulatory helix-turn-helix protein, lysR family
MAG.T22.39_01805	1380354.JIAN01000007_gene219	3.9e-133	481.5	Bacteria	thiY			ko:K02051		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17			Bacteria	COG0715@1,COG0715@2	NA|NA|NA	P	thiamine-containing compound biosynthetic process
MAG.T22.39_01806	326424.FRAAL1421	1.4e-56	226.5	Actinobacteria				ko:K02050,ko:K15599	ko02010,map02010	M00188,M00442			ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.3,3.A.1.17.6			Bacteria	2IFIB@201174,COG0600@1,COG0600@2	NA|NA|NA	P	inner membrane component
MAG.T22.39_01807	33876.JNXY01000040_gene6763	1.2e-90	339.7	Micromonosporales	tauB			ko:K02049		M00188			ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17			Bacteria	2GN33@201174,4DDRS@85008,COG1116@1,COG1116@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
MAG.T22.39_01808	326424.FRAAL1419	3.5e-62	245.4	Actinobacteria				ko:K02050,ko:K15599	ko02010,map02010	M00188,M00442			ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.3,3.A.1.17.6			Bacteria	2HDX7@201174,COG0600@1,COG0600@2	NA|NA|NA	P	PFAM binding-protein-dependent transport systems inner membrane component
MAG.T22.39_01809	1380390.JIAT01000010_gene4543	6.4e-153	547.0	Rubrobacteria													Bacteria	2GJRF@201174,4CPAN@84995,COG2141@1,COG2141@2	NA|NA|NA	C	Luciferase-like monooxygenase
MAG.T22.39_01810	526227.Mesil_1872	4.5e-216	757.3	Deinococcus-Thermus	mmsA		1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000				Bacteria	1WJFH@1297,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase family
MAG.T22.39_01811	1713.JOFV01000008_gene3079	1.1e-222	779.2	Cellulomonadaceae	hydA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016787,GO:0016810,GO:0016812,GO:0042802	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GK4A@201174,4F1VW@85016,COG0044@1,COG0044@2	NA|NA|NA	F	Amidohydrolase family
MAG.T22.39_01812	649831.L083_5308	7.5e-136	490.0	Micromonosporales			3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKRJ@201174,4D96X@85008,COG0388@1,COG0388@2	NA|NA|NA	S	Carbon-nitrogen hydrolase
MAG.T22.39_01813	1380354.JIAN01000007_gene226	4.2e-120	438.3	Cellulomonadaceae													Bacteria	2GM6I@201174,4F2IV@85016,COG1167@1,COG1167@2	NA|NA|NA	K	aminotransferase class I and II
MAG.T22.39_01814	1123320.KB889675_gene4054	1.7e-191	675.6	Actinobacteria			1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_01815	1504319.GM45_4525	1e-125	456.8	unclassified Actinobacteria (class)				ko:K11069	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GKVG@201174,3UWJS@52018,COG0687@1,COG0687@2	NA|NA|NA	E	Bacterial extracellular solute-binding protein
MAG.T22.39_01816	105425.BBPL01000012_gene1960	3.1e-129	468.4	Streptacidiphilus	potA		3.6.3.31	ko:K11072	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1			Bacteria	2GJCM@201174,2NG9M@228398,COG3842@1,COG3842@2	NA|NA|NA	E	TOBE domain
MAG.T22.39_01817	1504319.GM45_4535	1e-98	366.7	unclassified Actinobacteria (class)	potH			ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GJ5G@201174,3UWG9@52018,COG1176@1,COG1176@2	NA|NA|NA	P	COG1176 ABC-type spermidine putrescine transport system, permease component I
MAG.T22.39_01818	1386089.N865_10010	3.5e-85	321.6	Intrasporangiaceae	potC			ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1			Bacteria	2GJ6Q@201174,4FEZB@85021,COG1177@1,COG1177@2	NA|NA|NA	E	COG1177 ABC-type spermidine putrescine transport system, permease component II
MAG.T22.39_01819	653045.Strvi_2007	1.2e-149	536.6	Actinobacteria													Bacteria	2GJQ9@201174,COG0665@1,COG0665@2	NA|NA|NA	E	FAD dependent oxidoreductase
MAG.T22.39_01820	28444.JODQ01000016_gene7110	4.9e-142	510.8	Streptosporangiales			3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJA6@201174,4EI0Z@85012,COG0010@1,COG0010@2	NA|NA|NA	E	Arginase family
MAG.T22.39_01821	644283.Micau_0969	5.5e-167	594.0	Micromonosporales	lys1												Bacteria	2GMQ1@201174,4DA5G@85008,COG1748@1,COG1748@2	NA|NA|NA	E	Saccharopine dehydrogenase C-terminal domain
MAG.T22.39_01822	1157637.KB892115_gene4650	3.4e-170	604.7	Actinobacteria	gabT		2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GIS9@201174,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T22.39_01823	479433.Caci_7826	5.1e-156	557.8	Actinobacteria			1.2.1.3,1.2.1.9	ko:K00128,ko:K00131	ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00135,M00308,M00633	R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_01825	1122612.AUBA01000011_gene825	2.9e-10	71.2	Sphingomonadales													Bacteria	1Q5TH@1224,2AJXF@1,2KBZF@204457,2VC40@28211,31AKH@2	NA|NA|NA		
MAG.T22.39_01826	1282876.BAOK01000001_gene3410	3.4e-08	65.1	Alphaproteobacteria													Bacteria	1N2PV@1224,2DDX0@1,2U67F@28211,32U27@2	NA|NA|NA		
MAG.T22.39_01827	471852.Tcur_3372	7.8e-142	510.4	Streptosporangiales	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	Bacteria	2GIRV@201174,4EGGZ@85012,COG0743@1,COG0743@2	NA|NA|NA	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MAG.T22.39_01828	1172188.KB911821_gene1356	4.9e-105	388.3	Intrasporangiaceae	rseP			ko:K11749	ko02024,ko04112,map02024,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	2GJJT@201174,4FEQK@85021,COG0750@1,COG0750@2	NA|NA|NA	M	Peptidase family M50
MAG.T22.39_01829	446468.Ndas_3623	1.1e-174	619.4	Streptosporangiales	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS06430,iJN678.gcpE	Bacteria	2GK2S@201174,4EID0@85012,COG0821@1,COG0821@2	NA|NA|NA	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MAG.T22.39_01830	351607.Acel_1521	1.7e-74	286.2	Frankiales				ko:K06976					ko00000				Bacteria	2GMD2@201174,4ERYU@85013,COG3393@1,COG3393@2	NA|NA|NA	S	PFAM GCN5-related N-acetyltransferase
MAG.T22.39_01831	1120950.KB892747_gene3709	4.8e-241	840.5	Propionibacteriales	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJ9G@201174,4DN8W@85009,COG0442@1,COG0442@2	NA|NA|NA	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MAG.T22.39_01832	1122130.AUHN01000010_gene289	2.6e-58	232.3	Actinobacteria	yfcA			ko:K07090					ko00000				Bacteria	2GMNQ@201174,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
MAG.T22.39_01833	1246448.ANAZ01000015_gene5969	8.3e-32	143.7	Streptosporangiales	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K09748					ko00000,ko03009				Bacteria	2I9BT@201174,4EJF1@85012,COG0779@1,COG0779@2	NA|NA|NA	S	Required for maturation of 30S ribosomal subunits
MAG.T22.39_01834	196162.Noca_3192	2.8e-129	468.4	Propionibacteriales	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Bacteria	2GJDJ@201174,4DN47@85009,COG0195@1,COG0195@2	NA|NA|NA	K	Participates in both transcription termination and antitermination
MAG.T22.39_01835	452652.KSE_53060	2.5e-17	94.7	Kitasatospora	ylxR			ko:K02600,ko:K07742					ko00000,ko03009,ko03021				Bacteria	2GQH0@201174,2M5HH@2063,COG2740@1,COG2740@2	NA|NA|NA	K	Protein of unknown function (DUF448)
MAG.T22.39_01836	351607.Acel_1515	4.9e-277	960.7	Frankiales	infB			ko:K02519					ko00000,ko03012,ko03029				Bacteria	2GKPH@201174,4ERI2@85013,COG0532@1,COG0532@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MAG.T22.39_01837	1343740.M271_15420	6.3e-46	190.3	Actinobacteria	rbfA			ko:K02834					ko00000,ko03009				Bacteria	2IKXP@201174,COG0858@1,COG0858@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MAG.T22.39_01838	397278.JOJN01000001_gene2644	5.7e-73	281.2	Propionibacteriales	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177					ko00000,ko01000,ko03016				Bacteria	2GJZK@201174,4DPKY@85009,COG0130@1,COG0130@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MAG.T22.39_01839	446468.Ndas_3585	8.7e-72	277.3	Streptosporangiales	ribF		2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKQF@201174,4EHXD@85012,COG0196@1,COG0196@2	NA|NA|NA	H	Riboflavin kinase
MAG.T22.39_01840	1957.JODX01000026_gene4628	4.5e-34	150.2	Actinobacteria	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02956	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IQA0@201174,COG0184@1,COG0184@2	NA|NA|NA	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MAG.T22.39_01841	479433.Caci_7876	0.0	1119.4	Actinobacteria	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Bacteria	2GIT2@201174,COG1185@1,COG1185@2	NA|NA|NA	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MAG.T22.39_01842	1123320.KB889675_gene4004	2.2e-137	495.7	Actinobacteria	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GJZ3@201174,COG0612@1,COG0612@2	NA|NA|NA	S	Belongs to the peptidase M16 family
MAG.T22.39_01843	698964.CDPW8_1457	8.9e-80	303.5	Corynebacteriaceae	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000			iJN678.dapB,iYO844.BSU22490	Bacteria	22JSA@1653,2GM2T@201174,COG0289@1,COG0289@2	NA|NA|NA	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MAG.T22.39_01846	266940.Krad_0205	4.3e-20	104.0	Actinobacteria													Bacteria	2E45J@1,2GR89@201174,32Z1K@2	NA|NA|NA	S	branched-chain amino acid
MAG.T22.39_01847	479431.Namu_2770	3.3e-49	201.8	Frankiales													Bacteria	2GN6R@201174,4ESS4@85013,COG1296@1,COG1296@2	NA|NA|NA	E	AzlC protein
MAG.T22.39_01848	2045.KR76_02335	1.4e-16	95.1	Propionibacteriales													Bacteria	2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T22.39_01849	710111.FraQA3DRAFT_0378	4.4e-27	128.3	Actinobacteria													Bacteria	2I8Y7@201174,COG2197@1,COG2197@2	NA|NA|NA	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MAG.T22.39_01850	1121017.AUFG01000011_gene1728	1.8e-17	95.9	Intrasporangiaceae													Bacteria	2II4R@201174,4FGSV@85021,COG1247@1,COG1247@2	NA|NA|NA	M	N-acetyltransferase GCN5
MAG.T22.39_01851	351607.Acel_1504	7.5e-95	353.6	Actinobacteria	thyX		2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100		R06613	RC00022,RC00332	ko00000,ko00001,ko01000				Bacteria	2HCNJ@201174,COG1351@1,COG1351@2	NA|NA|NA	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant
MAG.T22.39_01852	1210045.ALNP01000036_gene2342	1.2e-93	349.7	Actinobacteria	dapA		4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ34@201174,COG0329@1,COG0329@2	NA|NA|NA	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAG.T22.39_01854	1449347.JQLN01000001_gene219	4.7e-10	72.0	Actinobacteria													Bacteria	29VDB@1,2HABQ@201174,30GU0@2	NA|NA|NA	S	Domain of unknown function (DUF4157)
MAG.T22.39_01855	164757.Mjls_0927	3.3e-25	123.2	Mycobacteriaceae	lysM			ko:K02453	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	237QT@1762,2IAAU@201174,COG1652@1,COG1652@2	NA|NA|NA	S	PFAM Peptidoglycan-binding
MAG.T22.39_01856	1206739.BAGJ01000274_gene3808	1.9e-46	194.1	Nocardiaceae													Bacteria	2GP13@201174,4G8CN@85025,COG3501@1,COG3501@2	NA|NA|NA	S	Rhs element Vgr protein
MAG.T22.39_01857	1463845.JOIG01000009_gene3137	1.2e-33	149.4	Actinobacteria				ko:K06903					ko00000				Bacteria	2IFJ6@201174,COG3628@1,COG3628@2	NA|NA|NA	S	GPW gp25 family protein
MAG.T22.39_01858	1123322.KB904661_gene4259	2e-155	556.2	Actinobacteria													Bacteria	2GM5C@201174,COG3299@1,COG3299@2	NA|NA|NA	S	Baseplate J-like protein
MAG.T22.39_01859	68170.KL590495_gene8103	3.2e-21	108.6	Pseudonocardiales													Bacteria	2HG1T@201174,4E3QS@85010,COG4385@1,COG4385@2	NA|NA|NA	S	Phage tail protein (Tail_P2_I)
MAG.T22.39_01861	1068980.ARVW01000001_gene7200	1.7e-18	101.3	Pseudonocardiales			2.7.11.1	ko:K07004,ko:K12132					ko00000,ko01000,ko01001				Bacteria	2H4ZH@201174,4DXVQ@85010,COG1470@1,COG1470@2	NA|NA|NA	S	cell adhesion involved in biofilm formation
MAG.T22.39_01863	1504319.GM45_0560	2.6e-43	182.2	unclassified Actinobacteria (class)													Bacteria	2I8Y7@201174,3UXGR@52018,COG2197@1,COG2197@2	NA|NA|NA	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MAG.T22.39_01864	1120934.KB894403_gene410	2.1e-12	81.3	Pseudonocardiales													Bacteria	2I8JH@201174,4DZ83@85010,COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase-like ATPases
MAG.T22.39_01865	1305732.JAGG01000001_gene1609	1.4e-28	134.8	Microbacteriaceae			3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200		R00527	RC00167,RC00320	ko00000,ko00001,ko01000		CE1		Bacteria	2GM6D@201174,4FNFH@85023,COG0438@1,COG0438@2,COG0627@1,COG0627@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T22.39_01866	110319.CF8_3316	2.1e-80	305.8	Propionibacteriales			2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000				Bacteria	2H2V9@201174,4DTMV@85009,COG0294@1,COG0294@2	NA|NA|NA	H	Pterin binding enzyme
MAG.T22.39_01867	272631.ML2177	5.6e-89	334.3	Bacteria	deoD_1		2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000				Bacteria	COG2820@1,COG2820@2	NA|NA|NA	F	uridine phosphorylase activity
MAG.T22.39_01868	318424.EU78_26820	3.6e-124	452.2	Mycobacteriaceae	sulP	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3			Bacteria	236K7@1762,2GJCB@201174,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate transporter
MAG.T22.39_01869	1121385.AQXW01000004_gene1699	7.6e-35	153.3	Dermacoccaceae													Bacteria	1ZW47@145357,2BX7X@1,2IKN7@201174,32RMD@2	NA|NA|NA	S	membrane
MAG.T22.39_01870	882083.SacmaDRAFT_5215	1.6e-08	65.9	Pseudonocardiales													Bacteria	2EP16@1,2IHWQ@201174,33GN1@2,4E68S@85010	NA|NA|NA		
MAG.T22.39_01872	1380354.JIAN01000005_gene2268	5.7e-10	71.2	Bacteria													Bacteria	COG0861@1,COG0861@2	NA|NA|NA	P	Integral membrane protein TerC family
MAG.T22.39_01873	338966.Ppro_1571	1.2e-110	407.1	Desulfuromonadales	ipdC		4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100		R01974	RC00506	ko00000,ko00001,ko01000				Bacteria	1MW2F@1224,2WKP7@28221,42NMB@68525,43TST@69541,COG3961@1,COG3961@2	NA|NA|NA	GH	Belongs to the TPP enzyme family
MAG.T22.39_01874	100226.SCO7159	1.7e-11	78.2	Actinobacteria													Bacteria	2GN5P@201174,COG1289@1,COG1289@2	NA|NA|NA	S	membrane
MAG.T22.39_01875	2002.JOEQ01000010_gene6383	4.2e-20	104.4	Streptosporangiales			1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	2GR9E@201174,4ER24@85012,COG1008@1,COG1008@2	NA|NA|NA	C	Domain of unknown function (DUF1707)
MAG.T22.39_01876	1184607.AUCHE_17_02120	6.2e-18	96.3	Dermatophilaceae													Bacteria	2GQJ9@201174,4F761@85018,COG2452@1,COG2452@2	NA|NA|NA	L	Helix-turn-helix domain
MAG.T22.39_01877	749414.SBI_05732	2.4e-86	325.9	Actinobacteria	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23	ko:K00271	ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130		R01212,R01434	RC00036	ko00000,ko00001,ko01000				Bacteria	2GKXG@201174,COG0334@1,COG0334@2	NA|NA|NA	E	Belongs to the Glu Leu Phe Val dehydrogenases family
MAG.T22.39_01878	1068978.AMETH_6906	1.9e-08	64.7	Pseudonocardiales													Bacteria	2EGRW@1,2IQF3@201174,33AI2@2,4E7DF@85010	NA|NA|NA	S	Protein of unknown function (DUF3073)
MAG.T22.39_01879	1123321.KB905820_gene5409	2.2e-122	445.7	Actinobacteria	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1844,iECSF_1327.ECSF_2340	Bacteria	2GJNY@201174,COG0150@1,COG0150@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine cyclo-ligase
MAG.T22.39_01880	1032480.MLP_06900	1.6e-213	748.8	Propionibacteriales	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	2GK6I@201174,4DN2S@85009,COG0034@1,COG0034@2	NA|NA|NA	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MAG.T22.39_01881	40571.JOEA01000006_gene4613	5.1e-81	308.1	Pseudonocardiales	fbpC		3.6.3.30	ko:K02010	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10			Bacteria	2GJCM@201174,4DZSI@85010,COG3842@1,COG3842@2	NA|NA|NA	E	TOBE domain
MAG.T22.39_01882	675635.Psed_6641	8e-99	367.9	Pseudonocardiales	sfuB			ko:K02011	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	2GKPT@201174,4DYQ1@85010,COG1178@1,COG1178@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_01883	1001240.GY21_06195	2e-88	332.8	Microbacteriaceae				ko:K02012	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000	3.A.1.10			Bacteria	2HS4R@201174,4FKVF@85023,COG1840@1,COG1840@2	NA|NA|NA	P	Bacterial extracellular solute-binding protein
MAG.T22.39_01884	1210046.B277_07985	1.5e-26	125.6	Intrasporangiaceae													Bacteria	2IQBF@201174,4FH9C@85021,COG3255@1,COG3255@2	NA|NA|NA	I	Sterol carrier protein
MAG.T22.39_01885	1463820.JOGW01000006_gene6645	0.0	1147.5	Actinobacteria	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKG6@201174,COG0046@1,COG0046@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T22.39_01886	44060.JODL01000021_gene4803	1.2e-102	379.4	Actinobacteria	purQ	GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMJY@201174,COG0047@1,COG0047@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T22.39_01887	1298863.AUEP01000010_gene4436	5.8e-20	103.2	Propionibacteriales	purS		6.3.2.6,6.3.5.3	ko:K01923,ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463,R04591	RC00010,RC00064,RC00162,RC01160	ko00000,ko00001,ko00002,ko01000			iYO844.BSU06460	Bacteria	2GQV4@201174,4DS4C@85009,COG1828@1,COG1828@2	NA|NA|NA	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAG.T22.39_01888	1214101.BN159_1610	5.2e-96	357.8	Actinobacteria	galE		5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMCW@201174,COG1087@1,COG1087@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family
MAG.T22.39_01889	749414.SBI_05716	6.6e-106	390.6	Actinobacteria	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945,ko:K03566	ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	2GK3H@201174,COG0152@1,COG0152@2	NA|NA|NA	F	Belongs to the SAICAR synthetase family
MAG.T22.39_01890	1120950.KB892790_gene2128	2.5e-184	651.7	Propionibacteriales	purB		4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKBR@201174,4DNYZ@85009,COG0015@1,COG0015@2	NA|NA|NA	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MAG.T22.39_01891	1048339.KB913029_gene1446	1.2e-145	523.1	Frankiales	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.3.1,6.3.4.13,6.3.5.3	ko:K01945,ko:K01952,ko:K11788,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208,R04463,R04591	RC00010,RC00064,RC00090,RC00162,RC00166,RC01100,RC01160	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530	Bacteria	2I2F5@201174,4ERHW@85013,COG0151@1,COG0151@2	NA|NA|NA	F	Belongs to the GARS family
MAG.T22.39_01892	1121933.AUHH01000010_gene2539	9.9e-33	146.0	Bacteria			3.4.16.4	ko:K01286					ko00000,ko01000				Bacteria	COG1680@1,COG1680@2	NA|NA|NA	V	peptidase activity
MAG.T22.39_01893	1504319.GM45_3440	7.5e-186	656.8	unclassified Actinobacteria (class)			2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100		R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000				Bacteria	2I2F3@201174,3UWC7@52018,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAG.T22.39_01894	1081644.IMCC13023_05780	3.3e-66	258.5	Microbacteriaceae	ydaF_1												Bacteria	2I90W@201174,4FNVS@85023,COG1670@1,COG1670@2	NA|NA|NA	J	Acetyltransferase (GNAT) domain
MAG.T22.39_01895	479433.Caci_0271	5e-198	697.2	Actinobacteria	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMP4@201174,COG0104@1,COG0104@2	NA|NA|NA	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MAG.T22.39_01896	1380356.JNIK01000011_gene1717	2.5e-66	259.2	Frankiales		GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363		ko:K06955					ko00000				Bacteria	2IA89@201174,4EUK4@85013,COG3380@1,COG3380@2	NA|NA|NA	S	Flavin containing amine oxidoreductase
MAG.T22.39_01897	67315.JOBD01000033_gene4208	2.6e-41	174.9	Actinobacteria													Bacteria	2BNGC@1,2I8BD@201174,32H4D@2	NA|NA|NA	S	Protein of unknown function (DUF3151)
MAG.T22.39_01898	710421.Mycch_2588	5e-106	391.0	Mycobacteriaceae	fda		4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147				Bacteria	233KA@1762,2GN1A@201174,COG3588@1,COG3588@2	NA|NA|NA	G	Aldolase
MAG.T22.39_01899	1283283.ATXA01000001_gene1009	8.2e-182	643.7	Frankiales	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GIU5@201174,4ERPY@85013,COG1061@1,COG1061@2	NA|NA|NA	L	PFAM type III restriction protein res subunit
MAG.T22.39_01900	1120950.KB892782_gene269	1.9e-83	315.5	Propionibacteriales	spoU		2.1.1.185	ko:K03218					ko00000,ko01000,ko03009				Bacteria	2GM1A@201174,4DN90@85009,COG0566@1,COG0566@2	NA|NA|NA	J	SpoU rRNA Methylase family
MAG.T22.39_01901	414996.IL38_02515	5.1e-77	294.7	Actinopolysporales				ko:K08974					ko00000				Bacteria	2I8HU@201174,407XR@622450,COG2035@1,COG2035@2	NA|NA|NA	S	Domain of unknown function (DUF368)
MAG.T22.39_01902	479432.Sros_0394	1.3e-51	209.5	Streptosporangiales	pyrE		2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000			iJN678.umpS	Bacteria	2GKUQ@201174,4EIPJ@85012,COG0461@1,COG0461@2	NA|NA|NA	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MAG.T22.39_01904	479435.Kfla_6748	1.4e-59	236.5	Propionibacteriales				ko:K07124					ko00000				Bacteria	2GKJE@201174,4DQTE@85009,COG0300@1,COG0300@2	NA|NA|NA	S	Belongs to the short-chain dehydrogenases reductases (SDR) family
MAG.T22.39_01905	1348663.KCH_54230	2.3e-31	143.7	Kitasatospora			3.4.21.4	ko:K01312	ko04080,ko04972,ko04974,ko05164,map04080,map04972,map04974,map05164				ko00000,ko00001,ko01000,ko01002,ko04147				Bacteria	2GN18@201174,2M0AJ@2063,COG5640@1,COG5640@2	NA|NA|NA	O	Trypsin-like serine protease
MAG.T22.39_01906	32051.SynWH7803_0851	3.9e-52	212.2	Bacteria													Bacteria	COG1960@1,COG1960@2	NA|NA|NA	I	acyl-CoA dehydrogenase activity
MAG.T22.39_01907	1463856.JOHY01000032_gene2960	3.2e-124	451.8	Actinobacteria	ybdL	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.17,2.6.1.88	ko:K14267,ko:K14287	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475,R08618	RC00006,RC00025	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJ7R@201174,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
MAG.T22.39_01908	1123504.JQKD01000012_gene1238	2.7e-36	158.3	Proteobacteria				ko:K07064					ko00000				Bacteria	1RK9K@1224,COG1848@1,COG1848@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_01909	1380347.JNII01000006_gene1328	2.2e-20	104.8	Frankiales													Bacteria	2IQ60@201174,4ETC4@85013,COG4339@1,COG4339@2	NA|NA|NA	S	Protein of unknown function (DUF4031)
MAG.T22.39_01910	436229.JOEH01000017_gene6930	0.0	1183.3	Streptacidiphilus	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944		ko:K03694,ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Bacteria	2GJ73@201174,2NGRH@228398,COG0542@1,COG0542@2	NA|NA|NA	O	C-terminal, D2-small domain, of ClpB protein
MAG.T22.39_01911	1120959.ATXF01000005_gene1360	7.3e-24	116.7	Microbacteriaceae	hspR			ko:K13640					ko00000,ko03000				Bacteria	2IQJ4@201174,4FP4F@85023,COG0789@1,COG0789@2	NA|NA|NA	K	helix_turn_helix, mercury resistance
MAG.T22.39_01912	452652.KSE_38160	3.8e-117	428.3	Kitasatospora	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679		ko:K03686,ko:K05516					ko00000,ko03029,ko03036,ko03110				Bacteria	2GJKK@201174,2M1TG@2063,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MAG.T22.39_01913	1394178.AWOO02000042_gene8764	4.4e-47	194.5	Streptosporangiales	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065		ko:K02652,ko:K03687					ko00000,ko02035,ko02044,ko03029,ko03110	3.A.15.2			Bacteria	2GP4F@201174,4EIMR@85012,COG0576@1,COG0576@2	NA|NA|NA	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MAG.T22.39_01914	1236902.ANAS01000005_gene4705	1e-207	729.6	Streptosporangiales	dnaK			ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	2GJTY@201174,4EFTK@85012,COG0443@1,COG0443@2	NA|NA|NA	O	Heat shock 70 kDa protein
MAG.T22.39_01916	1463856.JOHY01000008_gene977	8.2e-29	133.7	Actinobacteria	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03402					ko00000,ko03000				Bacteria	2GKA5@201174,COG1438@1,COG1438@2	NA|NA|NA	K	Regulates arginine biosynthesis genes
MAG.T22.39_01917	1172186.KB911471_gene2907	2.3e-119	435.6	Mycobacteriaceae	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	232PW@1762,2GKE9@201174,COG4992@1,COG4992@2	NA|NA|NA	E	acetylornithine aminotransferase
MAG.T22.39_01918	994479.GL877881_gene6239	4.9e-117	427.6	Pseudonocardiales	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784	Bacteria	2GKDS@201174,4DXB3@85010,COG0548@1,COG0548@2	NA|NA|NA	E	Belongs to the acetylglutamate kinase family. ArgB subfamily
MAG.T22.39_01919	1048339.KB913029_gene4047	3.2e-140	505.0	Frankiales	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIW0@201174,4ES7A@85013,COG1364@1,COG1364@2	NA|NA|NA	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MAG.T22.39_01920	351607.Acel_1263	4.6e-114	417.9	Frankiales	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKQK@201174,4ES9C@85013,COG0002@1,COG0002@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAG.T22.39_01921	1194165.CAJF01000006_gene2396	4.7e-07	61.6	Actinobacteria			3.2.1.14,3.2.1.65,3.2.1.80	ko:K01183,ko:K01212,ko:K03332	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100		R00879,R01206,R02334,R05624,R11311	RC00467,RC03278	ko00000,ko00001,ko01000		GH18,GH32		Bacteria	2GJ9T@201174,COG1621@1,COG1621@2,COG2755@1,COG2755@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 32 family
MAG.T22.39_01924	1449346.JQMO01000003_gene4278	1.9e-103	382.9	Kitasatospora	macB			ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	2GIRW@201174,2M21Z@2063,COG0577@1,COG0577@2	NA|NA|NA	V	MacB-like periplasmic core domain
MAG.T22.39_01925	512565.AMIS_48710	6.1e-75	287.3	Micromonosporales				ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GK3I@201174,4DAQ6@85008,COG1136@1,COG1136@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T22.39_01927	1137269.AZWL01000043_gene1263	1.2e-66	260.8	Actinobacteria													Bacteria	2GJM3@201174,COG1316@1,COG1316@2	NA|NA|NA	K	cell envelope-related transcriptional attenuator
MAG.T22.39_01928	1120959.ATXF01000010_gene75	7.4e-102	377.1	Microbacteriaceae		GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K07011					ko00000				Bacteria	2GK2D@201174,4FMHT@85023,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T22.39_01929	1416759.AYMR01000009_gene2958	8.6e-73	280.4	Microbacteriaceae													Bacteria	2GN3C@201174,4FKEI@85023,COG0558@1,COG0558@2	NA|NA|NA	I	CDP-alcohol phosphatidyltransferase
MAG.T22.39_01930	1394178.AWOO02000033_gene8438	3.2e-22	112.5	Streptosporangiales	wzt		3.6.3.38	ko:K01990,ko:K09689	ko02010,map02010	M00249,M00254			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101			Bacteria	2GIVF@201174,4EP8C@85012,COG1134@1,COG1134@2	NA|NA|NA	GM	ATPases associated with a variety of cellular activities
MAG.T22.39_01931	1451261.AS96_09970	6.4e-50	204.5	Microbacteriaceae	rfbA			ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103			Bacteria	2GP5K@201174,4FMSK@85023,COG1682@1,COG1682@2	NA|NA|NA	GM	ABC-2 type transporter
MAG.T22.39_01932	935839.JAGJ01000002_gene821	2.6e-81	308.5	Actinobacteria	phnW		2.6.1.37,2.7.7.74,2.7.8.12	ko:K03430,ko:K07281,ko:K09809	ko00440,ko00562,ko01100,ko01120,map00440,map00562,map01100,map01120		R04152,R09669	RC00002,RC00008,RC00062	ko00000,ko00001,ko01000,ko01007				Bacteria	2GN1Y@201174,COG1213@1,COG1213@2	NA|NA|NA	M	transferase
MAG.T22.39_01933	58123.JOFJ01000013_gene4912	2.2e-50	206.5	Streptosporangiales													Bacteria	2GJBP@201174,4EJFX@85012,COG0438@1,COG0438@2	NA|NA|NA	M	Glycosyl transferases group 1
MAG.T22.39_01934	1033730.CAHG01000012_gene1900	1.4e-66	260.0	Propionibacteriales	ywdF	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K06320,ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	2HZR3@201174,4DTNA@85009,COG1216@1,COG1216@2,COG4641@1,COG4641@2	NA|NA|NA	S	Glycosyl transferase family 2
MAG.T22.39_01935	269800.Tfu_2541	1.6e-95	356.3	Streptosporangiales	exoA												Bacteria	2GMWF@201174,4EHSA@85012,COG1215@1,COG1215@2	NA|NA|NA	M	Glycosyl transferase family 21
MAG.T22.39_01936	1033730.CAHG01000015_gene853	1.6e-42	180.6	Propionibacteriales													Bacteria	2I4J0@201174,4DWHK@85009,COG0463@1,COG0463@2	NA|NA|NA	M	Glycosyl transferase family 2
MAG.T22.39_01937	1463920.JOGB01000004_gene4693	5.1e-167	594.3	Actinobacteria	ugd		1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJQB@201174,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAG.T22.39_01938	935839.JAGJ01000007_gene3065	5.2e-37	160.6	Promicromonosporaceae	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06929					ko00000				Bacteria	2IHSP@201174,4F5WT@85017,COG1832@1,COG1832@2	NA|NA|NA	S	CoA binding domain
MAG.T22.39_01939	1171373.PACID_24130	1e-55	223.0	Propionibacteriales	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000			iJN678.purE,iNJ661.Rv3275c	Bacteria	2IFFD@201174,4DQ6R@85009,COG0041@1,COG0041@2	NA|NA|NA	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MAG.T22.39_01940	1171373.PACID_24140	2.3e-119	435.6	Propionibacteriales	purK	GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477	Bacteria	2GJCU@201174,4DPHF@85009,COG0026@1,COG0026@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MAG.T22.39_01941	1078020.KEK_22744	1.1e-25	123.2	Mycobacteriaceae													Bacteria	23467@1762,2GK6Y@201174,COG3428@1,COG3428@2	NA|NA|NA	S	Bacterial PH domain
MAG.T22.39_01942	1003195.SCAT_3821	2.6e-53	215.7	Actinobacteria	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	2.7.1.33,6.3.4.15	ko:K01947,ko:K03524	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	2GN8Q@201174,COG0340@1,COG0340@2	NA|NA|NA	H	biotin lipoate A B protein ligase
MAG.T22.39_01943	1385518.N798_09805	2.5e-236	824.7	Intrasporangiaceae	pccB		2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIRU@201174,4FEHJ@85021,COG4799@1,COG4799@2	NA|NA|NA	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MAG.T22.39_01944	1179773.BN6_76720	2.5e-08	64.3	Pseudonocardiales													Bacteria	2DFKT@1,2GT3J@201174,2ZS8K@2,4EF2U@85010	NA|NA|NA	S	Acyl-CoA carboxylase epsilon subunit
MAG.T22.39_01945	591158.SSMG_00626	8.3e-55	220.3	Actinobacteria	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	1.1.1.25,2.1.1.190	ko:K00014,ko:K03215,ko:K06287	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2GNI0@201174,COG0424@1,COG0424@2	NA|NA|NA	D	Maf-like protein
MAG.T22.39_01946	1223523.H340_20981	3.1e-248	864.4	Actinobacteria	bccA		6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIZP@201174,COG4770@1,COG4770@2	NA|NA|NA	I	carboxylase
MAG.T22.39_01947	43354.JOIJ01000019_gene4652	3.6e-40	171.0	Pseudonocardiales	ykqA												Bacteria	2GJM9@201174,4E2N8@85010,COG3703@1,COG3703@2	NA|NA|NA	P	AIG2-like family
MAG.T22.39_01948	1032480.MLP_13280	1.5e-149	536.2	Propionibacteriales	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GMP7@201174,4DNPF@85009,COG1249@1,COG1249@2	NA|NA|NA	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
MAG.T22.39_01949	1298863.AUEP01000001_gene946	2.5e-96	358.6	Propionibacteriales	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	2GKEI@201174,4DMXP@85009,COG0005@1,COG0005@2	NA|NA|NA	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MAG.T22.39_01950	1463856.JOHY01000011_gene6890	3.9e-168	598.2	Actinobacteria	pgcA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ3Q@201174,COG1109@1,COG1109@2	NA|NA|NA	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II
MAG.T22.39_01953	1120950.KB892785_gene249	4.8e-123	447.6	Propionibacteriales	deoC		4.1.2.4	ko:K01619	ko00030,map00030		R01066	RC00436,RC00437	ko00000,ko00001,ko01000				Bacteria	2GJIR@201174,4DNUJ@85009,COG0274@1,COG0274@2	NA|NA|NA	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MAG.T22.39_01954	471853.Bcav_0209	8.5e-228	796.2	Actinobacteria	aldA		1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_01955	68170.KL590471_gene4116	6.2e-109	400.6	Pseudonocardiales			1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKSN@201174,4DXRE@85010,COG1012@1,COG1012@2	NA|NA|NA	C	Aldehyde dehydrogenase
MAG.T22.39_01956	471853.Bcav_2739	3.1e-13	81.6	Actinobacteria	vapC												Bacteria	2INNM@201174,COG1487@1,COG1487@2	NA|NA|NA	S	ribonuclease activity
MAG.T22.39_01958	1504319.GM45_3445	1.2e-38	166.8	Actinobacteria			1.14.14.5	ko:K04091	ko00920,map00920		R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000				Bacteria	2GPKW@201174,COG2141@1,COG2141@2	NA|NA|NA	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAG.T22.39_01959	1121933.AUHH01000033_gene8	4.1e-51	208.0	Propionibacteriales													Bacteria	2GMVK@201174,4DTD1@85009,COG4243@1,COG4243@2	NA|NA|NA	S	VKc
MAG.T22.39_01960	1385521.N803_06500	6.6e-145	520.4	Intrasporangiaceae	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340		R01560,R02556	RC00477	ko00000,ko00001,ko01000			iNJ661.Rv3313c	Bacteria	2GJ6I@201174,4FEWW@85021,COG1816@1,COG1816@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily
MAG.T22.39_01961	190650.CC_1080	1.6e-07	63.5	Caulobacterales													Bacteria	1N0NK@1224,2KIW6@204458,2UCCE@28211,COG2197@1,COG2197@2	NA|NA|NA	KT	PFAM regulatory protein LuxR
MAG.T22.39_01962	246196.MSMEI_5385	3e-19	102.8	Actinobacteria													Bacteria	2FDAN@1,2GQHC@201174,345CJ@2	NA|NA|NA	S	Fusaric acid resistance protein-like
MAG.T22.39_01963	390989.JOEG01000023_gene5751	4.9e-39	167.2	Micromonosporales													Bacteria	2IMHT@201174,4DE67@85008,COG0662@1,COG0662@2	NA|NA|NA	G	Cupin 2, conserved barrel domain protein
MAG.T22.39_01964	446469.Sked_25720	2.7e-49	201.4	Actinobacteria	cdd	GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	2.4.2.4,3.5.4.5	ko:K00758,ko:K01489	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219		R01570,R01878,R02484,R02485,R08221,R08222,R08230	RC00063,RC00074,RC00514	ko00000,ko00001,ko01000				Bacteria	2IHP7@201174,COG0295@1,COG0295@2	NA|NA|NA	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MAG.T22.39_01965	1469613.JT55_05230	2.2e-121	442.6	Alphaproteobacteria				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	1MVDQ@1224,2TSTD@28211,COG1079@1,COG1079@2	NA|NA|NA	S	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01966	314271.RB2654_20933	1.4e-103	383.3	Alphaproteobacteria				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	1MX6V@1224,2TRXS@28211,COG4603@1,COG4603@2	NA|NA|NA	S	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_01967	314271.RB2654_20928	2.2e-162	578.9	Alphaproteobacteria	rbsA		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	1NT0H@1224,2UPJ8@28211,COG3845@1,COG3845@2	NA|NA|NA	S	ABC transporter
MAG.T22.39_01968	1547437.LL06_20730	1.6e-112	412.9	Phyllobacteriaceae				ko:K07335					ko00000				Bacteria	1NGHH@1224,2TR36@28211,43GX8@69277,COG1744@1,COG1744@2	NA|NA|NA	S	ABC-type transport system, periplasmic component surface lipoprotein
MAG.T22.39_01969	693444.D782_3196	5.2e-77	294.7	Gammaproteobacteria	rihA	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658		ko:K01250,ko:K12700					ko00000,ko01000			iEC55989_1330.EC55989_0645,iECSE_1348.ECSE_0721,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598	Bacteria	1MUIW@1224,1RSCY@1236,COG1957@1,COG1957@2	NA|NA|NA	G	Belongs to the IUNH family
MAG.T22.39_01970	457429.ABJI02000300_gene6792	1e-242	845.9	Actinobacteria	bhbA		5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM65@201174,COG1884@1,COG1884@2	NA|NA|NA	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAG.T22.39_01971	591158.SSMG_00542	1.3e-48	199.1	Actinobacteria	sdhC			ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	2IKU7@201174,COG2009@1,COG2009@2	NA|NA|NA	C	succinate dehydrogenase
MAG.T22.39_01972	882082.SaccyDRAFT_0638	7.8e-51	206.5	Pseudonocardiales	sdhD			ko:K00242,ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002				Bacteria	2GNKE@201174,4E2T2@85010,COG2142@1,COG2142@2	NA|NA|NA	C	Succinate dehydrogenase, hydrophobic anchor subunit
MAG.T22.39_01973	1123320.KB889688_gene406	4.7e-281	973.4	Actinobacteria	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111	Bacteria	2GJ45@201174,COG1053@1,COG1053@2	NA|NA|NA	C	succinate dehydrogenase
MAG.T22.39_01974	1123320.KB889688_gene407	9.2e-109	399.8	Actinobacteria	sdhB	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765	Bacteria	2GP9C@201174,COG0479@1,COG0479@2	NA|NA|NA	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein
MAG.T22.39_01975	585531.HMPREF0063_11132	4e-193	681.0	Propionibacteriales			1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GIWZ@201174,4DNDH@85009,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_01976	469371.Tbis_0672	4.2e-60	238.8	Pseudonocardiales	dac		3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	2GK3M@201174,4DXKV@85010,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
MAG.T22.39_01977	1435356.Y013_08040	6.3e-129	467.2	Nocardiaceae	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJ9A@201174,4FX09@85025,COG0180@1,COG0180@2	NA|NA|NA	J	Tryptophanyl-tRNA synthetase
MAG.T22.39_01978	1122138.AQUZ01000084_gene8782	9.2e-125	453.8	Propionibacteriales	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	2GKN5@201174,4DPDV@85009,COG1253@1,COG1253@2	NA|NA|NA	S	Transporter associated domain
MAG.T22.39_01979	298653.Franean1_1512	1.7e-61	243.0	Frankiales	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575		ko:K10805	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571	Bacteria	2GJ1B@201174,4EV8H@85013,COG1946@1,COG1946@2	NA|NA|NA	I	Acyl-CoA thioesterase
MAG.T22.39_01980	28444.JODQ01000002_gene4308	1.2e-203	715.7	Streptosporangiales	icd	GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GM3D@201174,4EFHD@85012,COG0538@1,COG0538@2	NA|NA|NA	C	Isocitrate/isopropylmalate dehydrogenase
MAG.T22.39_01981	65497.JODV01000007_gene344	5.6e-135	487.3	Pseudonocardiales	mdh		1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN5S@201174,4E787@85010,COG0039@1,COG0039@2	NA|NA|NA	C	lactate/malate dehydrogenase, alpha/beta C-terminal domain
MAG.T22.39_01982	326424.FRAAL1932	6.1e-104	384.0	Frankiales	clpL												Bacteria	2GMM2@201174,4ETQ9@85013,COG0714@1,COG0714@2	NA|NA|NA	S	PFAM ATPase associated with various cellular activities
MAG.T22.39_01983	1156844.KB891831_gene4788	2.6e-64	253.1	Actinobacteria				ko:K07161					ko00000				Bacteria	2GNTS@201174,COG3552@1,COG3552@2	NA|NA|NA	M	Protein containing von Willebrand factor type A (VWA) domain
MAG.T22.39_01985	1464048.JNZS01000007_gene4474	2.6e-69	268.9	Micromonosporales	pcaR			ko:K02624					ko00000,ko03000				Bacteria	2GNHA@201174,4D9QJ@85008,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
MAG.T22.39_01986	555793.WSK_3095	5.5e-47	194.1	Sphingomonadales													Bacteria	1RBR6@1224,28PSM@1,2K9CV@204457,2V0GH@28211,2ZCE4@2	NA|NA|NA		
MAG.T22.39_01987	1549858.MC45_16645	9.5e-122	443.4	Sphingomonadales													Bacteria	1NEGQ@1224,28IZD@1,2K8TY@204457,2UZGH@28211,2Z8WU@2	NA|NA|NA		
MAG.T22.39_01988	1218084.BBJK01000061_gene4738	4.5e-200	704.1	Burkholderiaceae			1.2.1.3,1.2.1.39,1.2.1.8	ko:K00128,ko:K00130,ko:K00146	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000				Bacteria	1JZMS@119060,1MU1V@1224,2VHNV@28216,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
MAG.T22.39_01989	882082.SaccyDRAFT_1534	3.6e-107	394.8	Pseudonocardiales	catI		2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120		R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000				Bacteria	2I9F6@201174,4DXHC@85010,COG1788@1,COG1788@2	NA|NA|NA	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MAG.T22.39_01990	42256.RradSPS_1068	2.1e-92	345.5	Rubrobacteria	catJ		2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120		R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000				Bacteria	2GMA1@201174,4CPVM@84995,COG2057@1,COG2057@2	NA|NA|NA	I	Coenzyme A transferase
MAG.T22.39_01991	1380393.JHVP01000004_gene682	2.6e-96	359.0	Frankiales	4hbD		1.1.1.61,1.3.1.32	ko:K00217,ko:K18120	ko00361,ko00362,ko00364,ko00623,ko00650,ko01100,ko01120,ko01200,ko01220,map00361,map00362,map00364,map00623,map00650,map01100,map01120,map01200,map01220		R01644,R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00087,RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000				Bacteria	2I2FD@201174,4ETWT@85013,COG1454@1,COG1454@2	NA|NA|NA	C	Iron-containing alcohol dehydrogenase
MAG.T22.39_01992	408672.NBCG_00685	1.9e-136	492.7	Actinobacteria				ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2IBBY@201174,COG0683@1,COG0683@2	NA|NA|NA	E	Periplasmic binding protein
MAG.T22.39_01993	408672.NBCG_00686	1.6e-65	256.1	Propionibacteriales				ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GMEE@201174,4DPPJ@85009,COG0411@1,COG0411@2	NA|NA|NA	E	Amino acid amide ABC transporter ATP-binding protein 1, HAAT family
MAG.T22.39_01994	408672.NBCG_00687	2.1e-83	315.5	Propionibacteriales				ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GKSQ@201174,4DUR7@85009,COG0410@1,COG0410@2	NA|NA|NA	E	ATPases associated with a variety of cellular activities
MAG.T22.39_01995	408672.NBCG_00688	1.3e-98	366.3	Propionibacteriales				ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	2GKAR@201174,4DRC7@85009,COG0559@1,COG0559@2	NA|NA|NA	P	Branched-chain amino acid transport system / permease component
MAG.T22.39_01996	1122611.KB903959_gene4233	2.1e-79	302.8	Bacteria				ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4			Bacteria	COG4177@1,COG4177@2	NA|NA|NA	E	L-phenylalanine transmembrane transporter activity
MAG.T22.39_01997	1463861.JNXE01000002_gene6635	3.6e-77	295.0	Actinobacteria			1.13.11.37	ko:K04098	ko00361,ko00362,ko01100,ko01120,map00361,map00362,map01100,map01120		R03891,R04061	RC00388,RC01016	ko00000,ko00001,ko01000				Bacteria	2GNNC@201174,COG3485@1,COG3485@2	NA|NA|NA	Q	catechol 1,2-dioxygenase
MAG.T22.39_01998	1408452.JAGZ01000001_gene3157	2.5e-64	252.3	Mycobacteriaceae	ttgV			ko:K13641					ko00000,ko03000				Bacteria	23799@1762,2HNJS@201174,COG1414@1,COG1414@2,COG1878@1,COG1878@2	NA|NA|NA	K	Putative cyclase
MAG.T22.39_01999	1123319.AUBE01000014_gene5420	1.9e-112	412.1	Actinobacteria			2.3.1.247	ko:K18013	ko00310,map00310		R10564	RC02728,RC03199	ko00000,ko00001,ko01000				Bacteria	2I9EQ@201174,COG3246@1,COG3246@2	NA|NA|NA	K	beta-keto acid cleavage enzyme
MAG.T22.39_02000	419947.MRA_1727	7.5e-26	123.2	Mycobacteriaceae			3.4.13.22	ko:K08641,ko:K11312	ko01502,ko02020,map01502,map02020	M00651			ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504				Bacteria	23C5U@1762,2GPTX@201174,COG3837@1,COG3837@2	NA|NA|NA	S	Cupin domain
MAG.T22.39_02001	557599.MKAN_28555	1.3e-135	489.2	Mycobacteriaceae													Bacteria	23799@1762,2HNJS@201174,COG1878@1,COG1878@2	NA|NA|NA	K	Putative cyclase
MAG.T22.39_02002	557599.MKAN_28550	1.4e-95	356.3	Mycobacteriaceae	fadB3		1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3	ko:K00074,ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	2393S@1762,2GPFP@201174,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
MAG.T22.39_02003	557599.MKAN_28545	7.2e-88	330.5	Mycobacteriaceae													Bacteria	2352P@1762,2GK20@201174,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T22.39_02004	1463903.JOIZ01000001_gene74	1.2e-95	356.3	Actinobacteria	scoA		2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650		R00410	RC00014	ko00000,ko00001,ko01000				Bacteria	2GK61@201174,COG1788@1,COG1788@2	NA|NA|NA	I	coenzyme A transferase
MAG.T22.39_02005	234621.RER_52840	1.2e-88	332.8	Nocardiaceae	scoB	GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0050896,GO:0070482	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650		R00410	RC00014	ko00000,ko00001,ko01000			iNJ661.Rv2503c	Bacteria	2GKV9@201174,4FWFR@85025,COG2057@1,COG2057@2	NA|NA|NA	I	transferase
MAG.T22.39_02006	1449355.JQNR01000005_gene2947	6.3e-111	407.5	Actinobacteria	pat		2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007				Bacteria	2GJXS@201174,COG0079@1,COG0079@2	NA|NA|NA	E	May catalyze the transamination reaction in phenylalanine biosynthesis
MAG.T22.39_02007	1079986.JH164861_gene7425	5.6e-157	560.8	Bacteria													Bacteria	COG0076@1,COG0076@2	NA|NA|NA	E	glutamate decarboxylase activity
MAG.T22.39_02008	1120950.KB892760_gene5727	6.4e-08	63.5	Bacteria													Bacteria	2DRQP@1,33CNM@2	NA|NA|NA	S	Protein of unknown function (DUF3017)
MAG.T22.39_02009	1116232.AHBF01000066_gene8772	6.1e-117	427.2	Actinobacteria	folD		1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJZS@201174,COG0190@1,COG0190@2	NA|NA|NA	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MAG.T22.39_02010	1123023.JIAI01000001_gene7515	1.8e-18	99.4	Pseudonocardiales				ko:K02529					ko00000,ko03000				Bacteria	2GJRG@201174,4DZYD@85010,COG1609@1,COG1609@2	NA|NA|NA	K	Periplasmic binding protein-like domain
MAG.T22.39_02011	479435.Kfla_4314	4.7e-46	191.8	Propionibacteriales				ko:K09936	ko02024,map02024				ko00000,ko00001,ko02000	2.A.7.21			Bacteria	2IB1U@201174,4DQZE@85009,COG3238@1,COG3238@2	NA|NA|NA	S	Putative inner membrane exporter, YdcZ
MAG.T22.39_02012	1278078.G419_03003	1.7e-202	712.2	Nocardiaceae	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147			iHN637.CLJU_RS04230,iJN678.purH	Bacteria	2GJWU@201174,4FUJ8@85025,COG0138@1,COG0138@2	NA|NA|NA	F	Bifunctional purine biosynthesis protein PurH
MAG.T22.39_02013	1287475.HMPREF1650_06500	2.8e-52	211.8	Corynebacteriaceae	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2,2.1.2.3,3.5.4.10	ko:K00602,ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04325,R04326,R04560	RC00026,RC00197,RC00263,RC00456,RC01128	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	22MYH@1653,2H8QB@201174,COG0299@1,COG0299@2	NA|NA|NA	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MAG.T22.39_02014	1121385.AQXW01000004_gene3221	2.4e-10	72.8	Actinobacteria	VP1530	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GN5K@201174,COG5473@1,COG5473@2	NA|NA|NA	J	Zn-ribbon protein possibly nucleic acid-binding
MAG.T22.39_02015	1120917.AQXM01000038_gene1996	3.9e-20	106.3	Micrococcaceae													Bacteria	1W7EP@1268,2I39E@201174,COG3266@1,COG3266@2	NA|NA|NA	S	domain, Protein
MAG.T22.39_02016	1298860.AUEM01000001_gene1048	1.5e-37	163.3	Microbacteriaceae				ko:K07090					ko00000				Bacteria	2GK5W@201174,4FM95@85023,COG0730@1,COG0730@2	NA|NA|NA	S	Sulfite exporter TauE/SafE
MAG.T22.39_02017	1504319.GM45_2375	1.2e-125	456.1	unclassified Actinobacteria (class)	sucD		6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK00@201174,3UWCZ@52018,COG0074@1,COG0074@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAG.T22.39_02018	446462.Amir_6508	1.5e-153	549.3	Pseudonocardiales	sucC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKSB@201174,4E03D@85010,COG0045@1,COG0045@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MAG.T22.39_02019	105420.BBPO01000010_gene2340	4.2e-52	210.7	Streptacidiphilus	icmB		5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	2IFJD@201174,2NIJA@228398,COG2185@1,COG2185@2	NA|NA|NA	I	B12 binding domain
MAG.T22.39_02020	561175.KB894103_gene1394	1.4e-32	147.1	Streptosporangiales	thcR												Bacteria	2IBP1@201174,4EJSD@85012,COG2207@1,COG2207@2	NA|NA|NA	K	AraC-binding-like domain
MAG.T22.39_02021	208444.JNYY01000014_gene4100	1.7e-63	249.2	Pseudonocardiales	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000				Bacteria	2GTN2@201174,4E2TX@85010,COG0655@1,COG0655@2	NA|NA|NA	S	NADPH-dependent FMN reductase
MAG.T22.39_02022	1048339.KB913029_gene4458	6.1e-55	220.7	Frankiales	azr		1.3.5.4,1.5.1.38,1.7.1.6	ko:K00244,ko:K00299,ko:K03206	ko00020,ko00190,ko00620,ko00650,ko00720,ko00740,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map00740,map00920,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164,R05706,R07210,R10206	RC00045,RC00126,RC01779,RC02556	ko00000,ko00001,ko00002,ko01000				Bacteria	2IFRY@201174,4ESUK@85013,COG0431@1,COG0431@2	NA|NA|NA	S	NADPH-dependent FMN reductase
MAG.T22.39_02023	1449976.KALB_3449	2.8e-64	252.3	Pseudonocardiales				ko:K02616					ko00000,ko03000				Bacteria	2GNME@201174,4E0B7@85010,COG3327@1,COG3327@2	NA|NA|NA	K	PaaX-like protein C-terminal domain
MAG.T22.39_02024	405948.SACE_0563	8.6e-161	573.5	Pseudonocardiales			1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020		R00214	RC00105	ko00000,ko00001,ko01000				Bacteria	2GJAJ@201174,4DXG2@85010,COG0281@1,COG0281@2	NA|NA|NA	C	Malic enzyme
MAG.T22.39_02025	1122182.KB903815_gene1558	1.1e-182	646.4	Micromonosporales			5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM65@201174,4D9MW@85008,COG1884@1,COG1884@2	NA|NA|NA	I	Methylmalonyl-CoA mutase
MAG.T22.39_02026	1122182.KB903815_gene1557	7.4e-145	520.8	Micromonosporales													Bacteria	2GIUC@201174,4DCHG@85008,COG0318@1,COG0318@2	NA|NA|NA	IQ	AMP-binding enzyme C-terminal domain
MAG.T22.39_02027	66429.JOFL01000001_gene4374	2.1e-163	582.8	Actinobacteria													Bacteria	2GKN1@201174,COG1042@1,COG1042@2	NA|NA|NA	C	CoA-binding domain protein
MAG.T22.39_02028	1156844.KB891851_gene3976	8.4e-45	186.4	Actinobacteria	abmE												Bacteria	2IHXH@201174,COG0251@1,COG0251@2	NA|NA|NA	J	endoribonuclease L-PSP
MAG.T22.39_02029	405948.SACE_3135	1.2e-76	293.1	Pseudonocardiales													Bacteria	2H0SM@201174,4E07R@85010,COG1028@1,COG1028@2	NA|NA|NA	IQ	Enoyl-(Acyl carrier protein) reductase
MAG.T22.39_02030	390989.JOEG01000022_gene2326	2e-134	485.7	Micromonosporales													Bacteria	2GJAC@201174,4D9J7@85008,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
MAG.T22.39_02031	1146883.BLASA_2572	9.2e-99	366.7	Frankiales	menB		4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000				Bacteria	2GK5G@201174,4ERHV@85013,COG0447@1,COG0447@2	NA|NA|NA	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily
MAG.T22.39_02032	698761.RTCIAT899_CH14195	3e-138	498.8	Rhizobiaceae													Bacteria	1MV2R@1224,2TSR0@28211,4B8Z0@82115,COG1233@1,COG1233@2	NA|NA|NA	Q	Flavin containing amine oxidoreductase
MAG.T22.39_02033	391937.NA2_09678	2.8e-123	449.1	Phyllobacteriaceae													Bacteria	1MV2R@1224,2TVAM@28211,43N7Q@69277,COG1233@1,COG1233@2	NA|NA|NA	Q	Flavin containing amine oxidoreductase
MAG.T22.39_02034	1157637.KB892107_gene3803	3.3e-154	551.6	Actinobacteria	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJPR@201174,COG0162@1,COG0162@2	NA|NA|NA	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MAG.T22.39_02035	1123261.AXDW01000007_gene2231	2.3e-33	149.1	Xanthomonadales	alkA		2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MX9C@1224,1S5J1@1236,1XCIQ@135614,COG0122@1,COG0122@2	NA|NA|NA	L	endonuclease III
MAG.T22.39_02036	662479.C440_06867	4e-07	61.2	Halobacteria													Archaea	23YUB@183963,2Y179@28890,arCOG03232@1,arCOG03232@2157	NA|NA|NA	S	PFAM VanZ family protein
MAG.T22.39_02037	1386089.N865_11245	2.1e-89	335.5	Intrasporangiaceae	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147			iJN678.argH	Bacteria	2GJ2A@201174,4FF12@85021,COG0165@1,COG0165@2	NA|NA|NA	E	Argininosuccinate lyase
MAG.T22.39_02038	1122138.AQUZ01000010_gene5121	1.6e-96	359.4	Propionibacteriales	rnj	GO:0003674,GO:0005488,GO:0005515,GO:0042802		ko:K12574	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	2GIW7@201174,4DMZI@85009,COG0595@1,COG0595@2	NA|NA|NA	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MAG.T22.39_02040	1122611.KB903962_gene4480	1.7e-109	402.5	Streptosporangiales	natA			ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322			ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6			Bacteria	2GMEE@201174,4EGR5@85012,COG0411@1,COG0411@2	NA|NA|NA	E	Branched-chain amino acid ATP-binding cassette transporter
MAG.T22.39_02041	1504319.GM45_6035	5.5e-101	374.4	unclassified Actinobacteria (class)	livM			ko:K01998,ko:K11955	ko02010,ko02024,map02010,map02024	M00237,M00322			ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6			Bacteria	2GJB3@201174,3UWEP@52018,COG4177@1,COG4177@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
MAG.T22.39_02042	1504319.GM45_6030	1e-99	370.5	unclassified Actinobacteria (class)				ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322			ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6			Bacteria	2GMAY@201174,3UWDA@52018,COG0559@1,COG0559@2	NA|NA|NA	E	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_02043	1210045.ALNP01000010_gene1112	8.4e-38	163.3	Actinobacteria	ydiI												Bacteria	2IKTU@201174,COG2050@1,COG2050@2	NA|NA|NA	Q	PFAM thioesterase superfamily
MAG.T22.39_02044	749414.SBI_07981	8.1e-277	959.9	Actinobacteria	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	2GJY2@201174,COG0258@1,COG0258@2,COG0749@1,COG0749@2	NA|NA|NA	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAG.T22.39_02045	452652.KSE_20210	1.4e-217	762.3	Kitasatospora	rpsA			ko:K02945	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GJAK@201174,2M0Q1@2063,COG0539@1,COG0539@2	NA|NA|NA	J	Ribosomal protein S1-like RNA-binding domain
MAG.T22.39_02046	1121362.A605_06750	3.3e-45	188.3	Corynebacteriaceae	coaE	GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464	2.7.1.24	ko:K00859,ko:K02096,ko:K02286,ko:K02290,ko:K02630,ko:K05378,ko:K05379,ko:K05380	ko00196,ko00770,ko01100,map00196,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko00194,ko01000				Bacteria	22MZB@1653,2GN96@201174,COG0237@1,COG0237@2	NA|NA|NA	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MAG.T22.39_02047	1003195.SCAT_1119	1.3e-309	1068.5	Actinobacteria	uvrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K03702,ko:K08999	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GJ03@201174,COG0556@1,COG0556@2	NA|NA|NA	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MAG.T22.39_02048	40571.JOEA01000014_gene1683	2.9e-83	315.5	Pseudonocardiales	alx			ko:K05794					ko00000				Bacteria	2GIWU@201174,4DYPS@85010,COG0861@1,COG0861@2	NA|NA|NA	P	PFAM Integral membrane protein TerC
MAG.T22.39_02049	318424.EU78_04830	1e-102	380.2	Mycobacteriaceae	alx			ko:K05794					ko00000				Bacteria	237CF@1762,2GIWU@201174,COG0861@1,COG0861@2	NA|NA|NA	P	membrane protein TerC
MAG.T22.39_02051	253839.SSNG_01776	1e-87	329.7	Actinobacteria													Bacteria	2GKJA@201174,COG0491@1,COG0491@2	NA|NA|NA	S	Zn-dependent
MAG.T22.39_02052	1169161.KB897721_gene4189	0.0	1496.9	Actinobacteria	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090		ko:K03701	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GJUV@201174,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MAG.T22.39_02053	1157637.KB892095_gene2806	2.7e-23	115.2	Actinobacteria													Bacteria	2IKSY@201174,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske 2Fe-2S
MAG.T22.39_02054	269800.Tfu_2021	4.4e-186	657.9	Streptosporangiales	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03703	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	2GIS4@201174,4EHD5@85012,COG0322@1,COG0322@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MAG.T22.39_02055	67257.JODR01000012_gene6108	7.1e-92	344.0	Actinobacteria	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K06958					ko00000,ko03019				Bacteria	2GMWB@201174,COG1660@1,COG1660@2	NA|NA|NA	S	Displays ATPase and GTPase activities
MAG.T22.39_02056	570268.ANBB01000037_gene2697	1.3e-99	369.8	Streptosporangiales	ybhK												Bacteria	2GJBW@201174,4EHPS@85012,COG0391@1,COG0391@2	NA|NA|NA	S	Required for morphogenesis under gluconeogenic growth conditions
MAG.T22.39_02057	66377.JOBH01000018_gene2448	1.7e-139	502.3	Actinobacteria	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944		ko:K09762					ko00000				Bacteria	2GJZU@201174,COG1481@1,COG1481@2	NA|NA|NA	K	May be required for sporulation
MAG.T22.39_02058	35754.JNYJ01000012_gene979	4e-144	517.7	Micromonosporales	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	2GJK4@201174,4D98B@85008,COG0057@1,COG0057@2	NA|NA|NA	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MAG.T22.39_02059	1120944.JONS01000018_gene1455	8e-131	473.8	Actinobacteria	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJC6@201174,4D3JI@85005,COG0126@1,COG0126@2	NA|NA|NA	F	Belongs to the phosphoglycerate kinase family
MAG.T22.39_02060	1206101.AZXC01000002_gene6135	1.1e-99	369.8	Actinobacteria	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJXZ@201174,COG0149@1,COG0149@2	NA|NA|NA	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MAG.T22.39_02061	196162.Noca_2533	1.7e-19	101.7	Propionibacteriales	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	2GR31@201174,4DS3V@85009,COG1314@1,COG1314@2	NA|NA|NA	U	Preprotein translocase SecG subunit
MAG.T22.39_02062	227882.SAV_6300	2e-44	184.9	Actinobacteria	rbpA												Bacteria	2CNY9@1,2IKKZ@201174,31GEE@2	NA|NA|NA	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters
MAG.T22.39_02063	570268.ANBB01000037_gene2724	2.1e-52	212.6	Streptosporangiales	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057,ko:K02003	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008,M00258	R02035	RC00537	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1			Bacteria	2GMQ2@201174,4EH59@85012,COG0363@1,COG0363@2	NA|NA|NA	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
MAG.T22.39_02064	1120950.KB892707_gene4632	9.8e-73	280.4	Propionibacteriales	opcA												Bacteria	2GJ1H@201174,4DP29@85009,COG3429@1,COG3429@2	NA|NA|NA	G	Glucose-6-phosphate dehydrogenase subunit
MAG.T22.39_02065	1122138.AQUZ01000001_gene1577	2.3e-231	808.1	Propionibacteriales	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147			iIT341.HP1101	Bacteria	2GISI@201174,4DNXH@85009,COG0364@1,COG0364@2	NA|NA|NA	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAG.T22.39_02066	211114.JOEF01000018_gene6249	2.4e-121	442.2	Pseudonocardiales	tal		2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMF9@201174,4DXR6@85010,COG0176@1,COG0176@2	NA|NA|NA	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MAG.T22.39_02067	44060.JODL01000003_gene2863	3.3e-233	814.7	Actinobacteria	tkt		2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ1K@201174,COG0021@1,COG0021@2	NA|NA|NA	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MAG.T22.39_02068	1304865.JAGF01000001_gene3441	2.6e-81	308.9	Cellulomonadaceae	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029				Bacteria	2GJMY@201174,4F11Z@85016,COG0109@1,COG0109@2	NA|NA|NA	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MAG.T22.39_02069	1121385.AQXW01000004_gene1221	1.2e-65	256.9	Dermacoccaceae	ctaA			ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4			Bacteria	1ZVU4@145357,2GJQX@201174,COG1612@1,COG1612@2	NA|NA|NA	O	Cytochrome oxidase assembly protein
MAG.T22.39_02070	1064537.AGSO01000005_gene47	1.5e-28	133.3	Dermabacteraceae				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GN6S@201174,4FBRP@85020,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 type transporter
MAG.T22.39_02071	570268.ANBB01000037_gene2742	9e-45	187.6	Streptosporangiales	drrA_2			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GJBF@201174,4EG18@85012,COG1131@1,COG1131@2	NA|NA|NA	V	AAA domain, putative AbiEii toxin, Type IV TA system
MAG.T22.39_02073	1449353.JQMQ01000005_gene3905	1.1e-41	177.6	Streptacidiphilus	manA	GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.14.13.81,5.3.1.8,5.4.2.8	ko:K01809,ko:K01840,ko:K04035	ko00051,ko00520,ko00860,ko01100,ko01110,ko01130,map00051,map00520,map00860,map01100,map01110,map01130	M00114	R01818,R01819,R06265,R06266,R06267,R10068	RC00376,RC00408,RC00741,RC01491,RC01492,RC03042	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_696,iECOK1_1307.ECOK1_1731,iECS88_1305.ECS88_1659,iSFV_1184.SFV_1629,iSF_1195.SF1636,iSFxv_1172.SFxv_1833,iS_1188.S1767,iUMN146_1321.UM146_09090,iUTI89_1310.UTI89_C1801	Bacteria	2GJXC@201174,2NH9T@228398,COG1482@1,COG1482@2	NA|NA|NA	G	Phosphomannose isomerase type I
MAG.T22.39_02074	1120948.KB903231_gene4741	2e-10	71.2	Pseudonocardiales	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	2HUT5@201174,4E6TY@85010,COG2835@1,COG2835@2	NA|NA|NA	S	Trm112p-like protein
MAG.T22.39_02075	443255.SCLAV_2112	1.8e-174	619.0	Actinobacteria	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	Bacteria	2GJQA@201174,COG1109@1,COG1109@2	NA|NA|NA	G	the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
MAG.T22.39_02076	1120950.KB892759_gene6289	5.4e-36	157.1	Propionibacteriales													Bacteria	2C7XW@1,2IQ5R@201174,32RR4@2,4DRSS@85009	NA|NA|NA	S	Protein of unknown function (DUF3499)
MAG.T22.39_02077	502025.Hoch_3817	2.6e-27	129.4	Myxococcales	lgt			ko:K13292					ko00000,ko01000				Bacteria	1Q2R4@1224,2WP0G@28221,2YWK4@29,438CQ@68525,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MAG.T22.39_02079	357808.RoseRS_4387	4.1e-27	128.3	Chloroflexia													Bacteria	2G932@200795,375X7@32061,COG1238@1,COG1238@2	NA|NA|NA	S	PFAM SNARE associated Golgi protein
MAG.T22.39_02080	1110697.NCAST_37_01540	2.6e-35	154.5	Nocardiaceae	higA			ko:K21498					ko00000,ko02048				Bacteria	2IR2S@201174,4G4KZ@85025,COG3093@1,COG3093@2	NA|NA|NA	K	Helix-turn-helix XRE-family like proteins
MAG.T22.39_02081	1128421.JAGA01000002_gene407	1e-18	100.5	Bacteria													Bacteria	COG0546@1,COG0546@2	NA|NA|NA	S	glycolate biosynthetic process
MAG.T22.39_02084	1173027.Mic7113_0392	1.8e-31	145.2	Cyanobacteria	pslG			ko:K21000	ko02025,map02025				ko00000,ko00001		GH39		Bacteria	1GANI@1117,COG3664@1,COG3664@2	NA|NA|NA	G	PFAM Glycosyl hydrolases family 39
MAG.T22.39_02088	1306174.JODP01000002_gene5748	1.4e-100	372.9	Actinobacteria				ko:K07184					ko00000				Bacteria	2GK10@201174,COG1938@1,COG1938@2	NA|NA|NA	S	PAC2 family
MAG.T22.39_02090	1206739.BAGJ01000158_gene6322	8e-166	590.5	Nocardiaceae	pgi		5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	2GJG0@201174,4FVB5@85025,COG0166@1,COG0166@2	NA|NA|NA	G	Belongs to the GPI family
MAG.T22.39_02091	351607.Acel_1820	1.6e-119	436.0	Frankiales	gnd2		1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2620,iNJ661.Rv1122	Bacteria	2I2DH@201174,4ES6V@85013,COG1023@1,COG1023@2	NA|NA|NA	G	6-phosphogluconate dehydrogenase (Decarboxylating)
MAG.T22.39_02092	1348663.KCH_67540	3.9e-129	468.0	Kitasatospora	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iNJ661.Rv2130c	Bacteria	2GJZR@201174,2M1UC@2063,COG0215@1,COG0215@2	NA|NA|NA	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins
MAG.T22.39_02093	1050202.KB913024_gene1150	1.8e-59	236.1	Actinopolysporales													Bacteria	2GME7@201174,408AE@622450,COG5032@1,COG5032@2	NA|NA|NA	BDLTU	Phosphatidylinositol
MAG.T22.39_02094	103733.JNYO01000016_gene3390	1.5e-50	206.1	Pseudonocardiales													Bacteria	298YA@1,2GIYI@201174,2ZW25@2,4E0D2@85010	NA|NA|NA	S	Protein of unknown function (DUF3090)
MAG.T22.39_02095	1306174.JODP01000002_gene5753	1.1e-55	223.4	Actinobacteria			3.1.3.3,3.1.3.73,5.4.2.11	ko:K01834,ko:K02226,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	2GK8N@201174,COG0406@1,COG0406@2	NA|NA|NA	G	phosphoglycerate mutase
MAG.T22.39_02096	196162.Noca_2624	3.1e-70	272.3	Propionibacteriales	corA			ko:K03284					ko00000,ko02000	1.A.35.1,1.A.35.3			Bacteria	2GKNZ@201174,4DPEQ@85009,COG0598@1,COG0598@2	NA|NA|NA	P	Mediates influx of magnesium ions
MAG.T22.39_02097	2045.KR76_13230	1.2e-87	329.7	Propionibacteriales	uppP		3.6.1.27	ko:K06153	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Bacteria	2GJVG@201174,4DN4Z@85009,COG1968@1,COG1968@2	NA|NA|NA	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MAG.T22.39_02098	1179773.BN6_41840	2.1e-143	515.4	Pseudonocardiales													Bacteria	2GIY3@201174,4DXE3@85010,COG2141@1,COG2141@2	NA|NA|NA	C	PFAM Luciferase-like monooxygenase
MAG.T22.39_02099	1123320.KB889662_gene1590	2e-111	409.1	Actinobacteria													Bacteria	2GMNA@201174,COG0667@1,COG0667@2	NA|NA|NA	C	aldo keto reductase
MAG.T22.39_02100	512565.AMIS_53990	5.6e-138	497.7	Micromonosporales													Bacteria	2GKKW@201174,4DA9I@85008,COG0624@1,COG0624@2	NA|NA|NA	E	Peptidase dimerisation domain
MAG.T22.39_02102	1166018.FAES_3906	7e-23	114.4	Cytophagia	gluQ		6.1.1.17	ko:K01885,ko:K01894	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016				Bacteria	47Q0Q@768503,4NP0Y@976,COG0008@1,COG0008@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
MAG.T22.39_02104	471852.Tcur_2808	1.6e-50	206.5	Streptosporangiales	echA12_1												Bacteria	2GJDK@201174,4EG47@85012,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase/isomerase
MAG.T22.39_02105	1137268.AZXF01000015_gene716	1.2e-62	246.1	Streptosporangiales													Bacteria	2GJGZ@201174,4EH75@85012,COG1051@1,COG1051@2	NA|NA|NA	F	Domain of unknown function (DUF4916)
MAG.T22.39_02106	1122622.ATWJ01000009_gene3031	7.7e-58	229.9	Intrasporangiaceae	msrB		1.8.4.12	ko:K07305					ko00000,ko01000				Bacteria	2IHV0@201174,4FGN2@85021,COG0229@1,COG0229@2	NA|NA|NA	O	Peptide-methionine (R)-S-oxide reductase
MAG.T22.39_02107	1121020.JIAG01000007_gene1934	2.9e-38	165.2	Micrococcaceae													Bacteria	1W8XI@1268,2AIF4@1,2GK8R@201174,318WM@2	NA|NA|NA	S	Protein of unknown function (DUF3000)
MAG.T22.39_02108	471853.Bcav_1962	4.9e-110	404.8	Actinobacteria	rnd		3.1.13.5	ko:K03684					ko00000,ko01000,ko03016				Bacteria	2GKNM@201174,COG0349@1,COG0349@2	NA|NA|NA	J	3-5 exonuclease
MAG.T22.39_02109	479432.Sros_6729	2e-161	575.5	Streptosporangiales	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767	Bacteria	2GJAC@201174,4EHSE@85012,COG0183@1,COG0183@2	NA|NA|NA	I	Thiolase, C-terminal domain
MAG.T22.39_02110	58123.JOFJ01000005_gene1331	2.5e-252	878.2	Streptosporangiales	fadB		1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ50@201174,4EG1F@85012,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
MAG.T22.39_02111	284031.JNXD01000005_gene3434	7.5e-232	810.1	Actinobacteria	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0456,iIT341.HP0354,iJN746.PP_0527	Bacteria	2GMFA@201174,COG1154@1,COG1154@2	NA|NA|NA	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MAG.T22.39_02112	1089455.MOPEL_130_00280	9.2e-11	73.2	Dermatophilaceae													Bacteria	2E8DB@1,2HYHF@201174,332RT@2,4F7YW@85018	NA|NA|NA		
MAG.T22.39_02113	928724.SacglDRAFT_02506	0.0	1313.5	Pseudonocardiales	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	2GJD5@201174,4DY9U@85010,COG1048@1,COG1048@2	NA|NA|NA	C	aconitate hydratase
MAG.T22.39_02114	1121272.KB903272_gene524	7.5e-57	228.0	Micromonosporales	trmA	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215					ko00000,ko01000,ko03009,ko03016				Bacteria	2GIR3@201174,4D8XD@85008,COG2265@1,COG2265@2	NA|NA|NA	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MAG.T22.39_02115	1504319.GM45_5020	4.6e-213	747.7	unclassified Actinobacteria (class)													Bacteria	2GK5V@201174,3UX33@52018,COG0531@1,COG0531@2	NA|NA|NA	E	Amino acid permease
MAG.T22.39_02116	1449353.JQMQ01000005_gene1726	6.8e-71	273.9	Streptacidiphilus	ceoB			ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2GK4N@201174,2NGQT@228398,COG0569@1,COG0569@2	NA|NA|NA	P	TrkA-C domain
MAG.T22.39_02117	1120950.KB892748_gene3219	3e-79	301.6	Propionibacteriales	trkA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4			Bacteria	2GKB9@201174,4DN0P@85009,COG0569@1,COG0569@2	NA|NA|NA	P	TrkA-C domain
MAG.T22.39_02118	1120950.KB892748_gene3215	4.9e-37	161.4	Propionibacteriales													Bacteria	2AVV0@1,2GJKP@201174,31MNQ@2,4DQXN@85009	NA|NA|NA	S	Protein of unknown function (DUF3159)
MAG.T22.39_02119	526225.Gobs_1874	1.6e-16	92.4	Frankiales			3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2IHRX@201174,4ETC1@85013,COG1200@1,COG1200@2	NA|NA|NA	KL	Nucleic acid binding, OB-fold, tRNA
MAG.T22.39_02120	590998.Celf_2147	1.4e-35	156.4	Cellulomonadaceae													Bacteria	28J4D@1,2I2E9@201174,30NZ9@2,4F14W@85016	NA|NA|NA	S	Protein of unknown function (DUF3710)
MAG.T22.39_02121	452652.KSE_54390	8.9e-40	169.9	Kitasatospora	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	2IHYY@201174,2M2SY@2063,COG0756@1,COG0756@2	NA|NA|NA	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
MAG.T22.39_02122	29306.JOBE01000001_gene2770	8.1e-49	200.3	Actinobacteria													Bacteria	2GKY1@201174,COG2050@1,COG2050@2	NA|NA|NA	Q	PFAM thioesterase superfamily
MAG.T22.39_02123	1463903.JOIZ01000010_gene3645	5.4e-12	77.8	Actinobacteria													Bacteria	2E4C2@1,2IFS5@201174,32Z7M@2	NA|NA|NA	S	Protein of unknown function (DUF3093)
MAG.T22.39_02125	1210046.B277_04322	1.2e-35	155.6	Intrasporangiaceae													Bacteria	2ATJW@1,2IKN0@201174,31J3Z@2,4FGXK@85021	NA|NA|NA	S	Domain of unknown function (DUF4193)
MAG.T22.39_02126	1121877.JQKF01000029_gene2115	3.4e-46	191.4	Acidimicrobiia													Bacteria	2GP22@201174,4CN21@84992,COG0663@1,COG0663@2	NA|NA|NA	S	Bacterial transferase hexapeptide (six repeats)
MAG.T22.39_02127	73044.JNXP01000027_gene2441	6.4e-63	247.7	Actinobacteria	suhB		3.1.3.25,4.99.1.1,4.99.1.9	ko:K01092,ko:K01772	ko00521,ko00562,ko00860,ko01100,ko01110,ko04070,map00521,map00562,map00860,map01100,map01110,map04070	M00121,M00131	R00310,R01185,R01186,R01187,R11329	RC00078,RC01012	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJQE@201174,COG0483@1,COG0483@2	NA|NA|NA	G	Inositol monophosphatase
MAG.T22.39_02128	479435.Kfla_3773	1.9e-61	243.4	Propionibacteriales													Bacteria	2GKMQ@201174,4DPX2@85009,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T22.39_02129	1033730.CAHG01000014_gene1555	2.5e-17	95.9	Propionibacteriales		GO:0008150,GO:0040007											Bacteria	28PUQ@1,2GNQM@201174,2ZCFK@2,4DR1M@85009	NA|NA|NA	S	Protein of unknown function (DUF3071)
MAG.T22.39_02130	235985.BBPN01000001_gene1227	4.3e-78	297.7	Streptacidiphilus	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000			iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470	Bacteria	2GP1W@201174,2NEXM@228398,COG1435@1,COG1435@2	NA|NA|NA	F	Thymidine kinase
MAG.T22.39_02131	258533.BN977_03846	4.3e-59	235.3	Mycobacteriaceae													Bacteria	233MR@1762,2GISU@201174,COG1524@1,COG1524@2	NA|NA|NA	S	type I phosphodiesterase nucleotide pyrophosphatase
MAG.T22.39_02132	2002.JOEQ01000027_gene7961	5.4e-56	224.2	Streptosporangiales													Bacteria	29850@1,2GKR1@201174,2ZVAX@2,4EHZV@85012	NA|NA|NA		
MAG.T22.39_02133	1306174.JODP01000013_gene7782	3.2e-23	115.2	Actinobacteria												iAF987.Gmet_2142	Bacteria	2GKN1@201174,COG0454@1,COG0456@2,COG1042@1,COG1042@2	NA|NA|NA	C	CoA-binding domain protein
MAG.T22.39_02134	1283283.ATXA01000001_gene968	9.9e-97	360.1	Frankiales	psuG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	4.2.1.70	ko:K16329	ko00240,map00240		R01055	RC00432,RC00433	ko00000,ko00001,ko01000				Bacteria	2GK19@201174,4ETX3@85013,COG2313@1,COG2313@2	NA|NA|NA	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway
MAG.T22.39_02135	446462.Amir_1498	9.3e-31	141.0	Pseudonocardiales			2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GP1C@201174,4DXYX@85010,COG0524@1,COG0524@2	NA|NA|NA	G	PFAM pfkB family carbohydrate kinase
MAG.T22.39_02136	397278.JOJN01000014_gene3578	1.1e-267	929.5	Propionibacteriales	gyrA	GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464	5.99.1.3	ko:K02469,ko:K02621					ko00000,ko01000,ko02048,ko03032,ko03036,ko03400				Bacteria	2GJ2Q@201174,4DPNM@85009,COG0188@1,COG0188@2	NA|NA|NA	L	DNA Topoisomerase IV
MAG.T22.39_02137	685727.REQ_34760	2.9e-27	129.4	Nocardiaceae													Bacteria	2GRSQ@201174,4FUAB@85025,COG4759@1,COG4759@2	NA|NA|NA	O	Sucrase/ferredoxin-like
MAG.T22.39_02138	1906.SFRA_30140	2.9e-37	161.8	Actinobacteria													Bacteria	2I38A@201174,COG0526@1,COG0526@2	NA|NA|NA	CO	Redoxin
MAG.T22.39_02139	1032480.MLP_36230	3.3e-109	402.1	Propionibacteriales	fprA		1.18.1.2,1.19.1.1	ko:K00528			R10159		ko00000,ko01000				Bacteria	2GJ4A@201174,4DP4B@85009,COG0493@1,COG0493@2	NA|NA|NA	C	4Fe-4S binding domain
MAG.T22.39_02140	1504319.GM45_4880	1.8e-44	185.7	unclassified Actinobacteria (class)	cah		4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000				Bacteria	2GM1M@201174,3UWU9@52018,COG0288@1,COG0288@2	NA|NA|NA	P	Carbonic anhydrase
MAG.T22.39_02141	471853.Bcav_1922	8.6e-105	386.7	Actinobacteria	gyrB2		5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	2GM1E@201174,COG0187@1,COG0187@2	NA|NA|NA	L	DNA topoisomerase (ATP-hydrolyzing)
MAG.T22.39_02142	446462.Amir_5218	3.6e-66	257.7	Pseudonocardiales	ribBA	GO:0005575,GO:0005576,GO:0008150,GO:0040007	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1415	Bacteria	2GIWJ@201174,4DXCJ@85010,COG0108@1,COG0108@2,COG0807@1,COG0807@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAG.T22.39_02143	479433.Caci_3109	5.2e-49	200.7	Actinobacteria	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000				Bacteria	2II1Z@201174,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MAG.T22.39_02144	1137269.AZWL01000001_gene5277	8.4e-25	119.4	Actinobacteria	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	Bacteria	2IQ4D@201174,COG0140@1,COG0140@2	NA|NA|NA	E	Phosphoribosyl-ATP
MAG.T22.39_02145	446468.Ndas_5380	2.9e-103	381.7	Streptosporangiales	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNAX@201174,4EGFE@85012,COG0040@1,COG0040@2	NA|NA|NA	E	ATP phosphoribosyltransferase
MAG.T22.39_02146	196162.Noca_2458	1.2e-24	119.8	Propionibacteriales				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	2GMN0@201174,4DRFX@85009,COG1404@1,COG1404@2	NA|NA|NA	O	SseB protein N-terminal domain
MAG.T22.39_02147	266940.Krad_3170	3.4e-34	151.0	Actinobacteria													Bacteria	2AI3Y@1,2IHSQ@201174,318HW@2	NA|NA|NA		
MAG.T22.39_02148	1288083.AUKR01000003_gene3651	8.4e-69	266.5	Actinobacteria	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Bacteria	2GJGT@201174,COG0290@1,COG0290@2	NA|NA|NA	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MAG.T22.39_02149	1713.JOFV01000004_gene3318	1.6e-17	94.7	Cellulomonadaceae	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02916	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQZW@201174,4F1JR@85016,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
MAG.T22.39_02150	479433.Caci_5481	4.9e-47	193.7	Actinobacteria	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02887	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHTN@201174,COG0292@1,COG0292@2	NA|NA|NA	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MAG.T22.39_02151	1121423.JONT01000013_gene296	2.4e-26	125.9	Peptococcaceae	spoU		2.1.1.185	ko:K03218,ko:K03437					ko00000,ko01000,ko03009,ko03016				Bacteria	1V3JP@1239,248DV@186801,261RV@186807,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAG.T22.39_02152	1151126.AQYI01000007_gene1443	1.8e-94	352.4	Actinobacteria													Bacteria	2EWQK@1,2IJ4T@201174,33Q2D@2	NA|NA|NA		
MAG.T22.39_02153	28444.JODQ01000006_gene471	1e-120	439.9	Streptosporangiales	cysD		1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	2GN85@201174,4EH12@85012,COG0175@1,COG0175@2	NA|NA|NA	EH	Phosphoadenosine phosphosulfate reductase family
MAG.T22.39_02154	1504319.GM45_2185	5e-204	717.6	unclassified Actinobacteria (class)	cysC		2.7.1.25,2.7.7.4	ko:K00860,ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJDX@201174,3UWEQ@52018,COG0529@1,COG0529@2,COG2895@1,COG2895@2	NA|NA|NA	P	Catalyzes the synthesis of activated sulfate
MAG.T22.39_02155	1906.SFRA_31005	3.8e-159	567.8	Actinobacteria	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GJGG@201174,COG0016@1,COG0016@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MAG.T22.39_02156	981369.JQMJ01000004_gene4302	3e-249	868.2	Streptacidiphilus	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	2GMFD@201174,2NFHY@228398,COG0072@1,COG0072@2,COG0073@1,COG0073@2	NA|NA|NA	J	B3/4 domain
MAG.T22.39_02157	311403.Arad_9746	1.2e-20	107.8	Rhizobiaceae													Bacteria	1RCS5@1224,2U6WZ@28211,4BIFI@82115,COG2211@1,COG2211@2	NA|NA|NA	G	MFS/sugar transport protein
MAG.T22.39_02158	211114.JOEF01000004_gene6450	2.6e-09	68.9	Pseudonocardiales													Bacteria	2I9BB@201174,4EESM@85010,COG1309@1,COG1309@2	NA|NA|NA	K	Tetracyclin repressor, C-terminal all-alpha domain
MAG.T22.39_02159	196162.Noca_3925	3.8e-10	71.2	Propionibacteriales	rpsL	GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02950	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2IHUF@201174,4DQR6@85009,COG0048@1,COG0048@2	NA|NA|NA	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MAG.T22.39_02161	316055.RPE_3904	4.8e-24	119.4	Alphaproteobacteria			2.7.11.1	ko:K04757					ko00000,ko01000,ko01001,ko03021				Bacteria	1RF4I@1224,2TY01@28211,COG2172@1,COG2172@2	NA|NA|NA	T	Histidine kinase-like ATPase domain
MAG.T22.39_02162	1121924.ATWH01000005_gene2551	2e-18	98.2	Actinobacteria													Bacteria	2BAGM@1,2H8NG@201174,323X7@2	NA|NA|NA		
MAG.T22.39_02163	1121877.JQKF01000012_gene319	5.4e-36	157.1	Actinobacteria	vapC	GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482											Bacteria	2ISE2@201174,COG1487@1,COG1487@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_02164	1121877.JQKF01000012_gene318	2.2e-09	67.4	Actinobacteria		GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050896,GO:0065007,GO:0070482											Bacteria	2GTYZ@201174,COG5450@1,COG5450@2	NA|NA|NA	K	Bacterial antitoxin of type II TA system, VapB
MAG.T22.39_02165	1048339.KB913029_gene2736	0.0	1957.6	Frankiales	rpoC	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	2GKWF@201174,4ERS7@85013,COG0086@1,COG0086@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAG.T22.39_02167	479432.Sros_6067	1.2e-45	190.7	Streptosporangiales													Bacteria	2GKX5@201174,4EIKK@85012,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T22.39_02168	1146883.BLASA_2474	6.6e-12	77.0	Actinobacteria	ssb1			ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	2GRPQ@201174,COG0629@1,COG0629@2	NA|NA|NA	L	Single-stranded DNA-binding protein
MAG.T22.39_02169	479432.Sros_6063	1.6e-21	109.4	Streptosporangiales													Bacteria	2IQ48@201174,4EJVW@85012,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
MAG.T22.39_02170	1463934.JOCF01000080_gene6005	1.3e-67	263.5	Actinobacteria	yutF	GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120		R03024	RC00151	ko00000,ko00001,ko01000				Bacteria	2GK7V@201174,COG0647@1,COG0647@2	NA|NA|NA	G	hydrolase
MAG.T22.39_02171	479435.Kfla_5423	5.4e-10	70.9	Propionibacteriales													Bacteria	2I1FP@201174,4DVQJ@85009,COG3937@1,COG3937@2	NA|NA|NA	S	granule-associated protein
MAG.T22.39_02173	469371.Tbis_2013	4.5e-77	294.7	Pseudonocardiales	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442					ko00000,ko01000,ko03009				Bacteria	2GJVT@201174,4DY8F@85010,COG1189@1,COG1189@2	NA|NA|NA	J	TIGRFAM hemolysin TlyA family protein
MAG.T22.39_02174	471852.Tcur_2170	5.5e-84	317.8	Streptosporangiales	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100		R00104	RC00002,RC00078	ko00000,ko00001,ko01000				Bacteria	2GKM2@201174,4EH46@85012,COG0061@1,COG0061@2	NA|NA|NA	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MAG.T22.39_02175	1463854.JOHT01000039_gene5493	8.3e-105	387.9	Actinobacteria	recN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360		ko:K03631,ko:K13582	ko04112,map04112				ko00000,ko00001,ko03400				Bacteria	2GIVG@201174,COG0497@1,COG0497@2	NA|NA|NA	L	May be involved in recombinational repair of damaged DNA
MAG.T22.39_02176	1048339.KB913029_gene4074	1.7e-264	918.3	Frankiales	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377	Bacteria	2GJ13@201174,4ERGE@85013,COG0504@1,COG0504@2	NA|NA|NA	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MAG.T22.39_02177	1095772.CAHH01000043_gene1157	5.4e-47	194.5	Actinobacteria	nudF		3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000				Bacteria	2GNW6@201174,COG0494@1,COG0494@2	NA|NA|NA	L	PFAM NUDIX hydrolase
MAG.T22.39_02178	710696.Intca_1842	4.9e-167	594.0	Intrasporangiaceae	ald		1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100		R00396	RC00008	ko00000,ko00001,ko01000				Bacteria	2GJ6G@201174,4FEV5@85021,COG0686@1,COG0686@2	NA|NA|NA	E	Belongs to the AlaDH PNT family
MAG.T22.39_02179	1122609.AUGT01000002_gene4076	2.5e-99	368.6	Propionibacteriales	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944		ko:K03496					ko00000,ko03036,ko04812				Bacteria	2GJX3@201174,4DP0V@85009,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose biosynthesis protein BcsQ
MAG.T22.39_02180	1048339.KB913029_gene4083	9.5e-97	360.1	Frankiales	scpA			ko:K05896					ko00000,ko03036				Bacteria	2GN1U@201174,4ERDV@85013,COG1354@1,COG1354@2	NA|NA|NA	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MAG.T22.39_02181	2002.JOEQ01000024_gene125	6.3e-58	230.7	Streptosporangiales	scpB			ko:K06024					ko00000,ko03036				Bacteria	2GISY@201174,4EG7D@85012,COG1386@1,COG1386@2	NA|NA|NA	K	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MAG.T22.39_02182	211114.JOEF01000008_gene1348	3.1e-77	295.0	Pseudonocardiales	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183					ko00000,ko01000,ko03009				Bacteria	2GJ4N@201174,4DXJJ@85010,COG1187@1,COG1187@2	NA|NA|NA	J	Belongs to the pseudouridine synthase RsuA family
MAG.T22.39_02183	1160718.SU9_31321	1.1e-35	156.0	Actinobacteria	aroH	GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704	2.7.4.25,5.4.99.5	ko:K00945,ko:K06208	ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230	M00024,M00025,M00052	R00158,R00512,R01665,R01715	RC00002,RC03116	ko00000,ko00001,ko00002,ko01000				Bacteria	2IHWT@201174,COG4401@1,COG4401@2	NA|NA|NA	E	Chorismate mutase
MAG.T22.39_02184	1120950.KB892761_gene5826	2.2e-82	312.8	Propionibacteriales	tyrA		1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000				Bacteria	2GKB4@201174,4DNB5@85009,COG0287@1,COG0287@2	NA|NA|NA	E	Prephenate dehydrogenase
MAG.T22.39_02185	1123319.AUBE01000019_gene2524	7.3e-57	227.3	Actinobacteria	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945,ko:K03977	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	2H3SI@201174,COG0283@1,COG0283@2	NA|NA|NA	F	Belongs to the cytidylate kinase family. Type 1 subfamily
MAG.T22.39_02187	1385518.N798_07805	2.9e-173	615.1	Intrasporangiaceae	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.399,1.1.1.95	ko:K00058,ko:K03977	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko03009,ko04147				Bacteria	2GJ8J@201174,4FED1@85021,COG1160@1,COG1160@2	NA|NA|NA	S	GTPase that plays an essential role in the late steps of ribosome biogenesis
MAG.T22.39_02191	1206732.BAGD01000081_gene3258	1.5e-08	66.6	Nocardiaceae													Bacteria	2GNDA@201174,4FYY6@85025,COG1073@1,COG1073@2	NA|NA|NA	S	alpha beta
MAG.T22.39_02192	1121952.ATXT01000016_gene440	6.7e-18	98.2	Microbacteriaceae													Bacteria	2E1SP@1,2I88S@201174,32V34@2,4FS0K@85023	NA|NA|NA	S	Domain of unknown function (DUF4436)
MAG.T22.39_02195	1449346.JQMO01000002_gene2006	7.8e-111	407.1	Kitasatospora				ko:K06916					ko00000,ko03036				Bacteria	2GNQA@201174,2M1G2@2063,COG1485@1,COG1485@2	NA|NA|NA	S	AFG1-like ATPase
MAG.T22.39_02197	1283299.AUKG01000002_gene4202	7.5e-10	72.4	Rubrobacteria	chiA		3.2.1.14	ko:K01183,ko:K14645	ko00520,ko01100,ko02024,map00520,map01100,map02024		R01206,R02334	RC00467	ko00000,ko00001,ko01000,ko01002,ko03110		GH18		Bacteria	2GJYH@201174,4CT88@84995,COG1404@1,COG1404@2,COG4733@1,COG4733@2	NA|NA|NA	O	Peptidase inhibitor I9
MAG.T22.39_02200	471852.Tcur_2107	1e-39	169.5	Streptosporangiales	pdxT	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750		R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000			iHN637.CLJU_RS19495	Bacteria	2GNYG@201174,4EH1T@85012,COG0311@1,COG0311@2	NA|NA|NA	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MAG.T22.39_02201	65497.JODV01000014_gene3329	3.6e-113	414.5	Pseudonocardiales	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	2GJ4G@201174,4DZF4@85010,COG0217@1,COG0217@2	NA|NA|NA	K	Transcriptional regulatory protein
MAG.T22.39_02202	1435356.Y013_16795	2.4e-73	283.1	Nocardiaceae													Bacteria	2GKU0@201174,4FXE2@85025,COG1020@1,COG1020@2	NA|NA|NA	Q	Protein of unknown function (DUF1298)
MAG.T22.39_02203	1303692.SFUL_1031	2e-46	192.2	Actinobacteria	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJI5@201174,COG0817@1,COG0817@2	NA|NA|NA	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MAG.T22.39_02204	1120936.KB907223_gene2477	6.9e-43	180.6	Streptosporangiales	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GN17@201174,4EGZC@85012,COG0632@1,COG0632@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MAG.T22.39_02205	313589.JNB_02455	1.2e-135	489.6	Intrasporangiaceae	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJZF@201174,4FEWP@85021,COG2255@1,COG2255@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MAG.T22.39_02206	1120972.AUMH01000001_gene1140	7e-15	86.7	Bacteria	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	COG1862@1,COG1862@2	NA|NA|NA	U	protein transport
MAG.T22.39_02207	1504319.GM45_5165	3.4e-135	488.8	unclassified Actinobacteria (class)	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	2GJTT@201174,3UWKE@52018,COG0342@1,COG0342@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T22.39_02208	68260.JOAY01000032_gene3195	1e-87	330.5	Actinobacteria	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	2GJRS@201174,COG0341@1,COG0341@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAG.T22.39_02209	1394178.AWOO02000029_gene4567	7.6e-44	183.7	Streptosporangiales	apt		2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147				Bacteria	2IM7C@201174,4EIYA@85012,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAG.T22.39_02210	351607.Acel_1338	5.5e-306	1056.6	Frankiales	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230		R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009				Bacteria	2GJYQ@201174,4EREV@85013,COG0317@1,COG0317@2	NA|NA|NA	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MAG.T22.39_02211	1504319.GM45_5180	2.2e-78	299.7	unclassified Actinobacteria (class)													Bacteria	2GJBD@201174,3UWJ7@52018,COG1196@1,COG1196@2	NA|NA|NA	D	Domain of Unknown Function (DUF349)
MAG.T22.39_02212	1504319.GM45_5185	5.3e-54	218.0	unclassified Actinobacteria (class)			5.2.1.8	ko:K01802,ko:K03768					ko00000,ko01000,ko03110				Bacteria	2GN8G@201174,3UWKX@52018,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T22.39_02213	1394178.AWOO02000029_gene4563	2.9e-64	251.9	Streptosporangiales	ycbL		3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000				Bacteria	2GJU0@201174,4EHV3@85012,COG0491@1,COG0491@2	NA|NA|NA	S	Metallo-beta-lactamase superfamily
MAG.T22.39_02214	103733.JNYO01000045_gene6209	2.8e-150	538.5	Pseudonocardiales	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	Bacteria	2GIYJ@201174,4DYW0@85010,COG0124@1,COG0124@2	NA|NA|NA	J	histidyl-tRNA synthetase
MAG.T22.39_02215	675635.Psed_3570	2.3e-259	901.4	Pseudonocardiales	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029				Bacteria	2GJHU@201174,4E0SI@85010,COG0173@1,COG0173@2	NA|NA|NA	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAG.T22.39_02216	452652.KSE_14270	2.2e-143	515.8	Kitasatospora	ycaJ			ko:K07478					ko00000				Bacteria	2GKDP@201174,2M1N5@2063,COG2256@1,COG2256@2	NA|NA|NA	L	AAA C-terminal domain
MAG.T22.39_02217	1048339.KB913029_gene504	8.8e-136	490.7	Frankiales													Bacteria	2GMUR@201174,4ES6B@85013,COG4805@1,COG4805@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF885)
MAG.T22.39_02218	1048339.KB913029_gene505	2.4e-60	238.8	Frankiales	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000				Bacteria	2GNKC@201174,4ESPN@85013,COG1694@1,COG3956@2	NA|NA|NA	S	PFAM MazG nucleotide pyrophosphohydrolase
MAG.T22.39_02219	1896.JOAU01000015_gene2078	8.6e-17	94.0	Actinobacteria	CP_0792		5.2.1.8	ko:K03770,ko:K03771,ko:K07533					ko00000,ko01000,ko03110				Bacteria	2GJDI@201174,COG0760@1,COG0760@2	NA|NA|NA	O	SurA N-terminal domain
MAG.T22.39_02220	67315.JOBD01000061_gene2105	0.0	1399.0	Actinobacteria	mfd			ko:K03723	ko03420,map03420				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJ42@201174,COG1197@1,COG1197@2	NA|NA|NA	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MAG.T22.39_02221	1504319.GM45_3020	9.9e-48	197.2	unclassified Actinobacteria (class)	cysQ		3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130		R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016				Bacteria	2GMW7@201174,3UXBX@52018,COG1218@1,COG1218@2	NA|NA|NA	P	Inositol monophosphatase family
MAG.T22.39_02222	1048339.KB913029_gene515	1.4e-59	236.1	Frankiales	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Bacteria	2GKCV@201174,4ESK5@85013,COG0193@1,COG0193@2	NA|NA|NA	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MAG.T22.39_02223	1123320.KB889688_gene424	3.4e-23	115.2	Actinobacteria	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02897	ko03010,map03010	M00178			ko00000,ko00001,ko00002,ko03011				Bacteria	2GJPJ@201174,COG1825@1,COG1825@2	NA|NA|NA	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MAG.T22.39_02224	1205910.B005_1153	2.7e-22	110.9	Streptosporangiales	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ9S@201174,4EGUF@85012,COG0462@1,COG0462@2	NA|NA|NA	EF	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MAG.T22.39_02225	1123023.JIAI01000008_gene1399	3.1e-158	565.8	Pseudonocardiales	dpp4		3.4.14.5	ko:K01278	ko04974,map04974				ko00000,ko00001,ko01000,ko01002,ko04090,ko04147				Bacteria	2GJ6A@201174,4DZ08@85010,COG1506@1,COG1506@2	NA|NA|NA	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region
MAG.T22.39_02226	28444.JODQ01000015_gene1798	4.7e-279	966.8	Streptosporangiales	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840		ko:K06207					ko00000				Bacteria	2GJUJ@201174,4EFWD@85012,COG1217@1,COG1217@2	NA|NA|NA	T	Elongation factor G C-terminus
MAG.T22.39_02227	446466.Cfla_2859	9e-31	139.8	Bacteria													Bacteria	COG0494@1,COG0494@2	NA|NA|NA	L	nUDIX hydrolase
MAG.T22.39_02228	529884.Rhola_00009770	6.4e-39	167.2	Bacteria													Bacteria	COG3832@1,COG3832@2	NA|NA|NA	J	glyoxalase III activity
MAG.T22.39_02229	1403819.BATR01000096_gene3150	1.2e-32	146.7	Verrucomicrobiae				ko:K04750					ko00000				Bacteria	2IWEY@203494,46W8S@74201,COG2764@1,COG2764@2	NA|NA|NA	S	3-demethylubiquinone-9 3-methyltransferase
MAG.T22.39_02230	429009.Adeg_0632	3.5e-07	60.5	Clostridia													Bacteria	1VJRI@1239,24UCF@186801,2ED1S@1,336YP@2	NA|NA|NA		
MAG.T22.39_02231	529884.Rhola_00003850	6.5e-17	92.8	Microbacteriaceae													Bacteria	2E3UG@1,2IQEJ@201174,32YRU@2,4FQRY@85023	NA|NA|NA	S	Domain of unknown function (DUF4287)
MAG.T22.39_02232	1108045.GORHZ_141_00580	2.6e-24	117.9	Gordoniaceae	relB		2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048				Bacteria	2GUI1@201174,4GEEA@85026,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T22.39_02233	68260.JOAY01000028_gene4148	1.9e-160	572.0	Actinobacteria	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464		ko:K06942					ko00000,ko03009				Bacteria	2GIXI@201174,COG0012@1,COG0012@2	NA|NA|NA	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MAG.T22.39_02235	1127134.NOCYR_4557	5.7e-127	460.7	Nocardiaceae	ispH		1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011			iIT341.HP0400,iLJ478.TM1444	Bacteria	2GIZ7@201174,4FU0D@85025,COG0761@1,COG0761@2	NA|NA|NA	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MAG.T22.39_02236	1048339.KB913029_gene104	1.4e-105	389.8	Frankiales	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJAS@201174,4ERQB@85013,COG1570@1,COG1570@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MAG.T22.39_02237	1394178.AWOO02000086_gene1018	7.7e-15	85.9	Streptosporangiales	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	2GR0U@201174,4EK9V@85012,COG1722@1,COG1722@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MAG.T22.39_02238	1352941.M877_13555	3.7e-13	81.6	Actinobacteria													Bacteria	2EID2@1,2IG1H@201174,33C4E@2	NA|NA|NA	S	Protein of unknown function (DUF4245)
MAG.T22.39_02239	66429.JOFL01000014_gene721	4.3e-138	497.7	Actinobacteria	glpX		3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	2GMQU@201174,COG1494@1,COG1494@2	NA|NA|NA	G	Fructose-1,6-bisphosphatase
MAG.T22.39_02240	767029.HMPREF9154_0828	2.3e-204	718.8	Propionibacteriales	ams		2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100		R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000		GH13		Bacteria	2GKT9@201174,4DNNS@85009,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain
MAG.T22.39_02241	1394178.AWOO02000086_gene1029	9.4e-242	842.8	Streptosporangiales	fumB	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676,ko:K01677,ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778,iPC815.YPO3335	Bacteria	2GK6D@201174,4EG9D@85012,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate
MAG.T22.39_02243	1120950.KB892823_gene569	4e-200	704.1	Propionibacteriales	phoH			ko:K07175					ko00000				Bacteria	2GK8U@201174,4DNRD@85009,COG1875@1,COG1875@2	NA|NA|NA	T	phosphate starvation-inducible protein PhoH
MAG.T22.39_02245	351607.Acel_1881	6.3e-100	370.5	Frankiales	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0033850,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110		R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006				Bacteria	2GJCP@201174,4ERVD@85013,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAG.T22.39_02246	1120950.KB892763_gene5582	4.1e-228	797.7	Propionibacteriales	yyaL			ko:K06888					ko00000				Bacteria	2GJ88@201174,4DPUB@85009,COG1331@1,COG1331@2	NA|NA|NA	O	Protein of unknown function, DUF255
MAG.T22.39_02247	1451261.AS96_12320	6.3e-201	707.2	Microbacteriaceae													Bacteria	2GJVW@201174,4FM0R@85023,COG1574@1,COG1574@2	NA|NA|NA	S	Amidohydrolase family
MAG.T22.39_02248	479431.Namu_3403	2.3e-90	339.7	Actinobacteria													Bacteria	2H4H5@201174,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
MAG.T22.39_02250	1386089.N865_17210	1.6e-31	142.1	Intrasporangiaceae	arsR9			ko:K03892					ko00000,ko03000				Bacteria	2IKK2@201174,4FJNI@85021,COG0640@1,COG0640@2	NA|NA|NA	K	helix_turn_helix, Arsenical Resistance Operon Repressor
MAG.T22.39_02251	1386089.N865_17205	1.6e-161	576.2	Intrasporangiaceae	sulP	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3		iSbBS512_1146.SbBS512_E1370	Bacteria	2GJCB@201174,4FIM1@85021,COG0659@1,COG0659@2	NA|NA|NA	P	Sulfate permease family
MAG.T22.39_02252	1134445.AJJM01000067_gene1687	4e-57	227.6	Actinobacteria													Bacteria	2IHSU@201174,COG1247@1,COG1247@2	NA|NA|NA	M	acetyltransferase
MAG.T22.39_02253	1150626.PHAMO_280021	1.2e-31	143.7	Rhodospirillales	budA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660		R02948	RC00812	ko00000,ko00001,ko01000				Bacteria	1MWDZ@1224,2JTFR@204441,2UA8I@28211,COG3527@1,COG3527@2	NA|NA|NA	Q	Belongs to the alpha-acetolactate decarboxylase family
MAG.T22.39_02254	37919.EP51_28655	4.7e-22	110.5	Nocardiaceae	mmr	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03297					ko00000,ko02000	2.A.7.1			Bacteria	2IKQZ@201174,4G246@85025,COG2076@1,COG2076@2	NA|NA|NA	P	Small Multidrug Resistance protein
MAG.T22.39_02257	1121017.AUFG01000007_gene1209	6.1e-12	76.6	Intrasporangiaceae				ko:K06218					ko00000,ko02048				Bacteria	2IRES@201174,4FHI4@85021,COG2026@1,COG2026@2	NA|NA|NA	DJ	ParE toxin of type II toxin-antitoxin system, parDE
MAG.T22.39_02258	1385520.N802_12210	1.9e-09	68.6	Intrasporangiaceae				ko:K19159					ko00000,ko02048				Bacteria	2IRS2@201174,4FHE3@85021,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
MAG.T22.39_02259	1144275.COCOR_03122	1.5e-09	69.3	Proteobacteria													Bacteria	1NKMZ@1224,COG3832@1,COG3832@2,COG5646@1,COG5646@2	NA|NA|NA	S	Domain of unknown function (DU1801)
MAG.T22.39_02260	298654.FraEuI1c_7019	4.5e-34	151.4	Frankiales				ko:K02019					ko00000,ko03000				Bacteria	2IKQV@201174,4ET46@85013,COG3585@1,COG3585@2	NA|NA|NA	H	DNA binding domain
MAG.T22.39_02261	367299.JOEE01000002_gene2218	1.5e-45	189.9	Intrasporangiaceae	modA			ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8			Bacteria	2GMPF@201174,4FEYN@85021,COG0725@1,COG0725@2	NA|NA|NA	P	molybdate-binding protein
MAG.T22.39_02262	369723.Strop_2546	1.2e-69	270.0	Micromonosporales	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8		iECO103_1326.ECO103_0752	Bacteria	2GJFB@201174,4DAIP@85008,COG4149@1,COG4149@2	NA|NA|NA	P	molybdate ABC transporter, inner membrane subunit
MAG.T22.39_02263	1108045.GORHZ_179_00050	1.7e-85	322.4	Gordoniaceae	ung	GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340				ko00000,ko00001,ko01000,ko03400				Bacteria	2GJ9Z@201174,4GAMJ@85026,COG0692@1,COG0692@2	NA|NA|NA	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MAG.T22.39_02266	1306174.JODP01000006_gene3641	2.9e-12	78.2	Bacteria													Bacteria	2E65S@1,32V4V@2	NA|NA|NA	S	Domain of unknown function (DUF3817)
MAG.T22.39_02267	1122939.ATUD01000002_gene1481	1.2e-59	236.9	Rubrobacteria	frk		2.7.1.20,2.7.1.4	ko:K00847,ko:K00856	ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100		R00185,R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	2GYHF@201174,4CQ63@84995,COG0524@1,COG0524@2	NA|NA|NA	G	pfkB family carbohydrate kinase
MAG.T22.39_02268	1123065.ATWL01000002_gene1726	1.4e-22	112.5	Actinobacteria													Bacteria	2GPFR@201174,COG4374@1,COG4374@2	NA|NA|NA	S	PIN domain
MAG.T22.39_02269	1122239.AULS01000002_gene928	7.2e-10	69.7	Bacteria													Bacteria	COG2002@1,COG2002@2	NA|NA|NA	K	toxin-antitoxin pair type II binding
MAG.T22.39_02270	1385520.N802_15925	1.4e-24	120.2	Intrasporangiaceae	surf1			ko:K14998					ko00000,ko03029	3.D.4.8			Bacteria	2GMGB@201174,4FGIW@85021,COG3346@1,COG3346@2	NA|NA|NA	S	SURF1-like protein
MAG.T22.39_02272	103733.JNYO01000012_gene2794	5e-98	364.4	Pseudonocardiales	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455					ko00000,ko01000				Bacteria	2H2NY@201174,4DYKF@85010,COG2120@1,COG2120@2	NA|NA|NA	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAG.T22.39_02273	1463821.JOGR01000003_gene879	2.7e-07	62.0	Glycomycetales													Bacteria	2B4Q5@1,2HZ3M@201174,31XGF@2,4F05C@85014	NA|NA|NA	S	Domain of unknown function (DUF4307)
MAG.T22.39_02274	1504319.GM45_3100	3.6e-46	191.4	unclassified Actinobacteria (class)	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Bacteria	2GNZV@201174,3UWPU@52018,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MAG.T22.39_02275	1449353.JQMQ01000005_gene2517	3.6e-72	278.5	Streptacidiphilus				ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GKJF@201174,2NEF7@228398,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-2 family transporter protein
MAG.T22.39_02276	1348663.KCH_47060	1.2e-103	383.3	Kitasatospora	drrA3			ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	2GIY8@201174,2M0XN@2063,COG1131@1,COG1131@2	NA|NA|NA	V	ATPases associated with a variety of cellular activities
MAG.T22.39_02277	446466.Cfla_2943	4.7e-07	60.5	Actinobacteria	vapB43	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944	2.1.1.63	ko:K10778					ko00000,ko01000,ko03000,ko03400				Bacteria	2GWKG@201174,COG3905@1,COG3905@2	NA|NA|NA	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MAG.T22.39_02278	1146883.BLASA_2354	1.1e-13	83.2	Actinobacteria		GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007		ko:K07064					ko00000				Bacteria	2GPX7@201174,COG1848@1,COG1848@2	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) module. An RNase
MAG.T22.39_02279	28444.JODQ01000003_gene4858	3.7e-115	421.8	Streptosporangiales	ilvA		4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iLJ478.TM0356	Bacteria	2GJAG@201174,4EHUF@85012,COG1171@1,COG1171@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T22.39_02280	258052.JNYV01000004_gene4074	2e-45	189.5	Actinobacteria													Bacteria	2AUNZ@1,2GP4I@201174,31KBW@2	NA|NA|NA	S	Protein of unknown function (DUF2786)
MAG.T22.39_02281	1121927.GOHSU_08_00940	1.6e-27	129.4	Gordoniaceae													Bacteria	2DPFG@1,2IG6V@201174,331UX@2,4GE8R@85026	NA|NA|NA		
MAG.T22.39_02282	1380386.JIAW01000005_gene1478	1.1e-53	217.6	Mycobacteriaceae	rhaB		2.7.1.17,2.7.1.5	ko:K00848,ko:K00854	ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120	M00014	R01639,R01902,R03014	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000				Bacteria	238BH@1762,2IE7F@201174,COG1070@1,COG1070@2	NA|NA|NA	G	FGGY family of carbohydrate kinases, N-terminal domain
MAG.T22.39_02283	509635.N824_13785	3.8e-95	354.8	Bacteroidetes													Bacteria	4P0GF@976,COG1830@1,COG1830@2	NA|NA|NA	G	DeoC/LacD family aldolase
MAG.T22.39_02284	479431.Namu_3968	2.6e-107	395.6	Bacteria													Bacteria	COG0673@1,COG0673@2	NA|NA|NA	S	inositol 2-dehydrogenase activity
MAG.T22.39_02285	1120950.KB892742_gene3038	1e-88	334.0	Propionibacteriales													Bacteria	2GK1K@201174,4DTNQ@85009,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major Facilitator Superfamily
MAG.T22.39_02286	1713.JOFV01000002_gene651	3.7e-74	284.6	Cellulomonadaceae	msrA		1.8.4.11	ko:K07304					ko00000,ko01000				Bacteria	2GJ1S@201174,4F10F@85016,COG0225@1,COG0225@2	NA|NA|NA	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAG.T22.39_02287	1504319.GM45_2400	4.4e-38	166.0	Actinobacteria				ko:K01446			R04112	RC00064,RC00141	ko00000				Bacteria	2IG5X@201174,COG3409@1,COG3409@2	NA|NA|NA	M	Peptidoglycan-binding domain 1 protein
MAG.T22.39_02288	1048339.KB913029_gene3472	2.8e-31	141.7	Actinobacteria				ko:K07075					ko00000				Bacteria	2GS5G@201174,COG1669@1,COG1669@2	NA|NA|NA	S	Nucleotidyltransferase domain
MAG.T22.39_02289	1146883.BLASA_4228	2.1e-73	282.3	Frankiales													Bacteria	2GMVD@201174,4ESNR@85013,COG2120@1,COG2120@2	NA|NA|NA	S	Evidence 2b Function of strongly homologous gene
MAG.T22.39_02290	1304865.JAGF01000001_gene590	2.2e-20	105.1	Bacteria													Bacteria	2E4PN@1,32ZIA@2	NA|NA|NA		
MAG.T22.39_02292	1048339.KB913029_gene2809	8.3e-229	799.7	Frankiales	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002			iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	Bacteria	2GM09@201174,4ERBR@85013,COG0519@1,COG0519@2	NA|NA|NA	F	Catalyzes the synthesis of GMP from XMP
MAG.T22.39_02294	479435.Kfla_0952	7.8e-63	247.3	Propionibacteriales	plsC1												Bacteria	2GKM6@201174,4DMZ0@85009,COG0204@1,COG0204@2	NA|NA|NA	I	Phosphate acyltransferases
MAG.T22.39_02296	110319.CF8_0632	1.8e-62	245.4	Propionibacteriales			1.2.5.3,1.3.99.16	ko:K03518,ko:K07302			R11168	RC02800	ko00000,ko01000				Bacteria	2GK8J@201174,4DQBR@85009,COG2080@1,COG2080@2	NA|NA|NA	C	[2Fe-2S] binding domain
MAG.T22.39_02297	479431.Namu_4147	0.0	1144.0	Frankiales			1.2.5.3	ko:K03520			R11168	RC02800	ko00000,ko01000				Bacteria	2GIVI@201174,4ERST@85013,COG1529@1,COG1529@2	NA|NA|NA	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism
MAG.T22.39_02298	1463825.JNXC01000039_gene2957	1.2e-91	343.2	Pseudonocardiales	cutM		1.2.5.3	ko:K03519			R11168	RC02800	ko00000,ko01000				Bacteria	2GT14@201174,4DXHU@85010,COG1319@1,COG1319@2	NA|NA|NA	C	carbon monoxide dehydrogenase
MAG.T22.39_02299	479435.Kfla_6020	1.5e-193	682.6	Propionibacteriales			1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120		R01459	RC00146	ko00000,ko00001,ko01000				Bacteria	2GJ3J@201174,4DNRG@85009,COG2303@1,COG2303@2	NA|NA|NA	E	GMC oxidoreductase
MAG.T22.39_02300	1123320.KB889574_gene5504	1.4e-148	533.1	Actinobacteria	gabD2		1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10	ko:K00135,ko:K22445	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000				Bacteria	2GJ95@201174,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
MAG.T22.39_02301	1464048.JNZS01000010_gene5087	7.6e-55	220.7	Micromonosporales													Bacteria	2H8JM@201174,4DFU8@85008,COG0491@1,COG0491@2	NA|NA|NA	S	Metallo-beta-lactamase superfamily
MAG.T22.39_02303	266940.Krad_1080	1.8e-44	186.4	Actinobacteria													Bacteria	2GNCK@201174,COG4760@1,COG4760@2	NA|NA|NA	S	membrane
MAG.T22.39_02304	1386089.N865_17555	4.3e-47	194.5	Intrasporangiaceae				ko:K13652					ko00000,ko03000				Bacteria	2IHU0@201174,4FJ2R@85021,COG3449@1,COG3449@2	NA|NA|NA	L	SOUL heme-binding protein
MAG.T22.39_02306	1121272.KB903250_gene2835	2.5e-60	238.8	Micromonosporales	MA20_42490		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Bacteria	2GJMH@201174,4D93K@85008,COG0412@1,COG0412@2	NA|NA|NA	Q	Dienelactone hydrolase family
MAG.T22.39_02307	479432.Sros_7167	1.7e-121	443.0	Streptosporangiales			3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110		R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000				Bacteria	2GJAF@201174,4EHCC@85012,COG2723@1,COG2723@2	NA|NA|NA	G	Glycosyl hydrolase family 1
MAG.T22.39_02308	105422.BBPM01000064_gene537	7.3e-106	390.6	Streptacidiphilus	aglG			ko:K02026,ko:K10234	ko02010,map02010	M00201,M00207			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8			Bacteria	2GJNN@201174,2NG0B@228398,COG0395@1,COG0395@2	NA|NA|NA	G	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_02309	105422.BBPM01000064_gene538	8.2e-110	403.7	Streptacidiphilus				ko:K02025,ko:K10233,ko:K15771	ko02010,map02010	M00201,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.32,3.A.1.1.8			Bacteria	2GKYS@201174,2NHRK@228398,COG1175@1,COG1175@2	NA|NA|NA	G	Binding-protein-dependent transport system inner membrane component
MAG.T22.39_02310	1121946.AUAX01000008_gene7300	5.4e-142	511.1	Micromonosporales				ko:K10232	ko02010,map02010	M00201			ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8			Bacteria	2GJXB@201174,4DB28@85008,COG1653@1,COG1653@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
MAG.T22.39_02311	494419.ALPM01000079_gene1978	2.8e-127	461.8	Micrococcaceae				ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1			Bacteria	1W80X@1268,2GJCM@201174,COG3842@1,COG3842@2	NA|NA|NA	E	ABC transporter
MAG.T22.39_02312	269800.Tfu_0833	3.9e-160	571.6	Streptosporangiales			3.2.1.10,3.2.1.20,3.2.1.93	ko:K01182,ko:K01187,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13,GH31		Bacteria	2GKS4@201174,4EI1B@85012,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha-amylase domain
MAG.T22.39_02313	479433.Caci_5761	5.8e-82	311.2	Actinobacteria													Bacteria	2GJBJ@201174,COG1609@1,COG1609@2	NA|NA|NA	K	lacI family
MAG.T22.39_02314	1123320.KB889574_gene5704	1.5e-81	309.7	Actinobacteria	ppx	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	2GJBN@201174,COG0248@1,COG0248@2	NA|NA|NA	FP	Ppx GppA phosphatase
MAG.T22.39_02315	1172188.KB911825_gene3742	5.9e-56	223.8	Intrasporangiaceae	ppx2		3.6.1.11,3.6.1.40	ko:K01524,ko:K09009	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000				Bacteria	2I8CS@201174,4FGC6@85021,COG1507@1,COG1507@2	NA|NA|NA	S	Protein of unknown function (DUF501)
MAG.T22.39_02316	1214101.BN159_5187	1.2e-14	86.7	Actinobacteria	divIC			ko:K05589,ko:K13052					ko00000,ko03036				Bacteria	2GQH7@201174,COG2919@1,COG2919@2	NA|NA|NA	D	septum formation initiator
MAG.T22.39_02317	196162.Noca_0928	1.1e-181	642.9	Propionibacteriales	eno		4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147				Bacteria	2GJAY@201174,4DPWS@85009,COG0148@1,COG0148@2	NA|NA|NA	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MAG.T22.39_02319	1343740.M271_27280	0.0	1373.6	Actinobacteria	clpC			ko:K03696	ko01100,map01100				ko00000,ko03110				Bacteria	2GJ77@201174,COG0542@1,COG0542@2	NA|NA|NA	O	associated with various cellular activities
MAG.T22.39_02321	1150599.MPHLEI_25666	5.5e-122	444.1	Mycobacteriaceae	yhhW_2			ko:K06911					ko00000				Bacteria	234Q9@1762,2GIY9@201174,COG1741@1,COG1741@2	NA|NA|NA	S	Belongs to the pirin family
MAG.T22.39_02322	298654.FraEuI1c_3650	3.5e-08	64.7	Bacteria													Bacteria	COG0229@1,COG0229@2	NA|NA|NA	O	peptide-methionine (R)-S-oxide reductase activity
MAG.T22.39_02323	882083.SacmaDRAFT_3101	4.6e-53	213.8	Pseudonocardiales	lsfA		1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	2GM74@201174,4E0A5@85010,COG0450@1,COG0450@2	NA|NA|NA	O	Redoxin
MAG.T22.39_02324	1110697.NCAST_23_00340	2.3e-12	77.4	Nocardiaceae	fadD15	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0015645,GO:0016020,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044464,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1			Bacteria	2GIXQ@201174,4FVXN@85025,COG1022@1,COG1022@2	NA|NA|NA	I	AMP-binding enzyme
MAG.T22.39_02325	1048339.KB913029_gene4616	3.3e-43	182.6	Frankiales				ko:K21471,ko:K21473					ko00000,ko01000,ko01002,ko01011				Bacteria	2GIWB@201174,4ESXT@85013,COG0791@1,COG0791@2	NA|NA|NA	M	PFAM NLP P60 protein
MAG.T22.39_02326	1068980.ARVW01000001_gene5522	9.7e-10	68.9	Pseudonocardiales													Bacteria	2EGHN@1,2GSZ1@201174,33A9R@2,4E7HS@85010	NA|NA|NA		
MAG.T22.39_02327	1386089.N865_01825	3.5e-128	464.9	Intrasporangiaceae	lldD	GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100		R00196	RC00044	ko00000,ko00001,ko01000				Bacteria	2GJA5@201174,4FH88@85021,COG1304@1,COG1304@2	NA|NA|NA	C	FMN-dependent dehydrogenase
MAG.T22.39_02328	1380347.JNII01000005_gene3191	2.2e-298	1031.2	Frankiales	rhaD												Bacteria	2GNEI@201174,4ETTI@85013,COG1028@1,COG1028@2,COG3347@1,COG3347@2	NA|NA|NA	IQ	Class II Aldolase and Adducin N-terminal domain
MAG.T22.39_02329	1463821.JOGR01000004_gene2419	4.5e-171	607.4	Glycomycetales	rhaI		5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120		R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000				Bacteria	2GK1Z@201174,4EZ66@85014,COG4952@1,COG4952@2	NA|NA|NA	M	Isomerase
MAG.T22.39_02330	1907.SGLAU_29795	8.6e-40	169.5	Actinobacteria	rhaU		5.1.3.32	ko:K03534			R10819	RC00563	ko00000,ko01000				Bacteria	2IQ69@201174,COG3254@1,COG3254@2	NA|NA|NA	S	L-rhamnose mutarotase
MAG.T22.39_02331	1122239.AULS01000002_gene815	4.4e-66	258.5	Microbacteriaceae	rhaS			ko:K02058,ko:K10559	ko02010,map02010	M00220,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.9			Bacteria	2I43Z@201174,4FMN4@85023,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
MAG.T22.39_02332	1121381.JNIV01000041_gene1103	6.8e-65	254.6	Deinococcus-Thermus	rhaQ			ko:K10561	ko02010,map02010	M00220			ko00000,ko00001,ko00002,ko02000	3.A.1.2.9			Bacteria	1WM7X@1297,COG1172@1,COG1172@2	NA|NA|NA	G	Monosaccharide ABC transporter membrane protein, CUT2 family
MAG.T22.39_02333	1123023.JIAI01000002_gene5679	5.7e-66	258.1	Pseudonocardiales	rhaP			ko:K10560	ko02010,map02010	M00220			ko00000,ko00001,ko00002,ko02000	3.A.1.2.9			Bacteria	2GM6S@201174,4DZ1F@85010,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
MAG.T22.39_02334	1156844.KB891825_gene768	1.9e-150	539.3	Actinobacteria	rbsA		3.6.3.17	ko:K10441,ko:K10562	ko02010,map02010	M00212,M00220			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9			Bacteria	2GJ3F@201174,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MAG.T22.39_02335	1382306.JNIM01000001_gene22	2.6e-82	312.4	Bacteria				ko:K02529					ko00000,ko03000				Bacteria	COG1609@1,COG1609@2	NA|NA|NA	K	purine nucleotide biosynthetic process
MAG.T22.39_02336	653045.Strvi_7221	6e-18	96.7	Actinobacteria													Bacteria	2ES7R@1,2IQ6C@201174,33JSG@2	NA|NA|NA		
MAG.T22.39_02337	1121385.AQXW01000004_gene1325	1.2e-143	516.9	Dermacoccaceae	cho	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03763,ko:K05984	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1ZVR8@145357,2GMC0@201174,COG0322@1,COG0322@2,COG2176@1,COG2176@2	NA|NA|NA	L	3' exoribonuclease, RNase T-like
MAG.T22.39_02338	1292020.H483_0104185	7.4e-52	210.7	Actinobacteria	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000				Bacteria	2GM4G@201174,COG0547@1,COG0547@2	NA|NA|NA	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MAG.T22.39_02339	1463861.JNXE01000040_gene4677	2.7e-52	212.2	Actinobacteria			2.7.11.1,4.6.1.1	ko:K01768,ko:K12132,ko:K21397	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000	3.A.1			Bacteria	2GNU2@201174,COG1716@1,COG1716@2	NA|NA|NA	T	(FHA) domain
MAG.T22.39_02340	1463856.JOHY01000002_gene1409	1.8e-36	159.1	Actinobacteria	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944											Bacteria	2GKA7@201174,COG1716@1,COG1716@2	NA|NA|NA	T	(FHA) domain
MAG.T22.39_02341	1157637.KB892098_gene2086	8e-82	311.2	Actinobacteria			3.1.3.16	ko:K20074					ko00000,ko01000,ko01009				Bacteria	2GJ3M@201174,COG0631@1,COG0631@2	NA|NA|NA	T	Phosphatase
MAG.T22.39_02342	935866.JAER01000017_gene4377	6.7e-132	477.6	Propionibacteriales	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136		ko:K03588,ko:K05364,ko:K05837	ko00550,ko04112,map00550,map04112		R04519	RC00005,RC00049	ko00000,ko00001,ko01011,ko02000,ko03036	2.A.103.1			Bacteria	2GJTI@201174,4DPN4@85009,COG0772@1,COG0772@2	NA|NA|NA	D	Belongs to the SEDS family
MAG.T22.39_02343	1120950.KB892743_gene3151	7.7e-128	464.2	Propionibacteriales	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05364	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01011				Bacteria	2GJUQ@201174,4DP0A@85009,COG0768@1,COG0768@2	NA|NA|NA	M	Penicillin binding protein transpeptidase domain
MAG.T22.39_02344	1504319.GM45_1805	8.1e-143	514.2	unclassified Actinobacteria (class)													Bacteria	2GJ1J@201174,3UW9J@52018,COG0515@1,COG0515@2	NA|NA|NA	KLT	Serine threonine protein kinase
MAG.T22.39_02346	436229.JOEH01000010_gene5196	1.7e-74	285.8	Streptacidiphilus	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664,ko:K13950	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000				Bacteria	2GJUX@201174,2NFQD@228398,COG0512@1,COG0512@2	NA|NA|NA	EH	Peptidase C26
MAG.T22.39_02347	1288083.AUKR01000021_gene1464	5e-12	77.0	Actinobacteria	crgA												Bacteria	2E4NY@1,2GQPW@201174,32ZHR@2	NA|NA|NA	D	involved in cell division
MAG.T22.39_02348	1121934.AUDX01000013_gene1704	2.9e-146	525.0	Microbacteriaceae													Bacteria	2GJAC@201174,4FKZ0@85023,COG0183@1,COG0183@2	NA|NA|NA	I	Thiolase, C-terminal domain
MAG.T22.39_02349	1122611.KB903952_gene5829	3.5e-46	191.8	Streptosporangiales	gluP		3.4.21.105	ko:K19225					ko00000,ko01000,ko01002				Bacteria	2GJYG@201174,4EH62@85012,COG0705@1,COG0705@2	NA|NA|NA	S	Rhomboid family
MAG.T22.39_02350	1048339.KB913029_gene1711	9.3e-68	263.1	Frankiales	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217				ko00000,ko00001,ko01000,ko03110,ko04147				Bacteria	2IFUE@201174,4ESIC@85013,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAG.T22.39_02351	1266909.AUAG01000009_gene586	4.8e-13	82.0	Gammaproteobacteria				ko:K06149					ko00000				Bacteria	1NBKV@1224,1SHMY@1236,COG0589@1,COG0589@2	NA|NA|NA	T	Universal stress protein family
MAG.T22.39_02352	47839.CCAU010000011_gene5318	2.9e-108	398.7	Mycobacteriaceae	dhpS		2.5.1.105	ko:K06897	ko00790,map00790		R10339	RC00121	ko00000,ko00001,ko01000				Bacteria	23ACA@1762,2I8H7@201174,COG1237@1,COG1237@2	NA|NA|NA	S	Metallo-beta-lactamase superfamily
MAG.T22.39_02353	1246995.AFR_22960	4.8e-192	680.2	Micromonosporales			2.7.11.1,3.2.1.4	ko:K01179,ko:K12567	ko00500,ko01100,ko05410,ko05414,map00500,map01100,map05410,map05414		R06200,R11307,R11308		ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812		GH5,GH9		Bacteria	2H7QD@201174,4DJZF@85008,COG4733@1,COG4733@2	NA|NA|NA	NU	Fibronectin type III domain
MAG.T22.39_02354	529884.Rhola_00000910	5e-26	125.6	Bacteria			2.7.13.3	ko:K07680,ko:K07778,ko:K11617	ko02020,ko02024,map02020,map02024	M00476,M00479,M00481,M00754			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	COG4585@1,COG4585@2	NA|NA|NA	T	Histidine kinase
MAG.T22.39_02355	529884.Rhola_00000920	8.6e-34	150.6	Microbacteriaceae				ko:K03413,ko:K07684,ko:K07689	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00471,M00475,M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Bacteria	2IJY1@201174,4FS4V@85023,COG2197@1,COG2197@2	NA|NA|NA	T	cheY-homologous receiver domain
MAG.T22.39_02359	1283287.KB822575_gene768	2.1e-24	118.6	Propionibacteriales		GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	2GKZP@201174,4DR9G@85009,COG3266@1,COG3266@2	NA|NA|NA	S	Transmembrane domain of unknown function (DUF3566)
MAG.T22.39_02360	1133850.SHJG_5197	0.0	1192.2	Actinobacteria	gyrA	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097	5.99.1.3	ko:K02469					ko00000,ko01000,ko03032,ko03400				Bacteria	2GJ2Q@201174,COG0188@1,COG0188@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T22.39_02361	1048339.KB913029_gene1673	2.4e-289	1001.1	Frankiales	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	2GKGP@201174,4ES0Z@85013,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAG.T22.39_02362	263358.VAB18032_04490	3.1e-33	148.3	Micromonosporales													Bacteria	2GNQ4@201174,4DD2D@85008,COG5512@1,COG5512@2	NA|NA|NA	S	Protein of unknown function (DUF721)
MAG.T22.39_02363	1283287.KB822575_gene772	7.2e-108	397.5	Propionibacteriales	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K03629,ko:K07459	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	2GJCS@201174,4DNK0@85009,COG1195@1,COG1195@2	NA|NA|NA	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MAG.T22.39_02364	436229.JOEH01000010_gene5299	1e-127	463.4	Streptacidiphilus	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	2GJK3@201174,2NEBF@228398,COG0592@1,COG0592@2	NA|NA|NA	L	DNA polymerase III beta subunit, C-terminal domain
MAG.T22.39_02365	1504319.GM45_6225	6.7e-193	680.2	unclassified Actinobacteria (class)	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837		ko:K02313	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Bacteria	2GJKI@201174,3UW7I@52018,COG0593@1,COG0593@2	NA|NA|NA	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MAG.T22.39_02366	1160718.SU9_14351	2.7e-11	73.6	Actinobacteria	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02914	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	2GQFY@201174,COG0230@1,COG0230@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL34 family
MAG.T22.39_02367	883169.HMPREF9719_01795	4.5e-13	80.9	Corynebacteriaceae	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998					ko00000,ko01000,ko03016				Bacteria	22PA0@1653,2GR42@201174,COG0594@1,COG0594@2	NA|NA|NA	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MAG.T22.39_02369	1504319.GM45_6245	2.1e-94	352.4	unclassified Actinobacteria (class)	yidC			ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Bacteria	2GJBU@201174,3UWKK@52018,COG0706@1,COG0706@2	NA|NA|NA	U	60Kd inner membrane protein
MAG.T22.39_02370	1160718.SU9_14331	6.1e-48	197.2	Actinobacteria	jag			ko:K06346,ko:K09749					ko00000				Bacteria	2GPZK@201174,COG1847@1,COG1847@2	NA|NA|NA	S	R3H domain protein
MAG.T22.39_02371	649831.L083_8207	5e-52	211.1	Micromonosporales	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501					ko00000,ko01000,ko03009,ko03036				Bacteria	2GM9Z@201174,4DCVP@85008,COG0357@1,COG0357@2	NA|NA|NA	J	Specifically methylates the N7 position of a guanine in 16S rRNA
MAG.T22.39_02372	1303692.SFUL_3566	8.9e-83	313.5	Actinobacteria	parA			ko:K03496					ko00000,ko03036,ko04812				Bacteria	2GMU7@201174,COG1192@1,COG1192@2	NA|NA|NA	D	chromosome partitioning
MAG.T22.39_02373	471852.Tcur_4977	1.2e-81	310.1	Streptosporangiales	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944		ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	2GNRN@201174,4EG88@85012,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
MAG.T22.39_02374	1120950.KB892740_gene2527	1.4e-93	349.7	Propionibacteriales	ddl		6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	2GRWM@201174,4DNS4@85009,COG1181@1,COG1181@2	NA|NA|NA	M	Belongs to the D-alanine--D-alanine ligase family
MAG.T22.39_02375	479433.Caci_9047	1.3e-155	556.2	Actinobacteria	avtA			ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210		R01939	RC00006	ko00000,ko00001,ko01000				Bacteria	2GITW@201174,COG1167@1,COG1167@2	NA|NA|NA	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAG.T22.39_02376	1120950.KB892740_gene2531	7.8e-90	337.4	Propionibacteriales	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.17,3.5.1.28	ko:K01185,ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Bacteria	2GPA9@201174,4DN51@85009,COG0860@1,COG0860@2,COG3409@1,COG3409@2	NA|NA|NA	M	Ami_3
MAG.T22.39_02377	1504319.GM45_6275	1.5e-36	158.7	unclassified Actinobacteria (class)	trxA		1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko01000,ko03110				Bacteria	2IQ9T@201174,3UWW6@52018,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin
MAG.T22.39_02378	1385518.N798_03990	1.7e-136	492.3	Intrasporangiaceae	trxB	GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K22345	ko00030,ko00450,map00030,map00450		R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000			iPC815.YPO1374	Bacteria	2GKD2@201174,4FEXJ@85021,COG0492@1,COG0492@2	NA|NA|NA	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MAG.T22.39_02380	1120950.KB892740_gene2535	3.6e-55	221.5	Propionibacteriales	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03088					ko00000,ko03021				Bacteria	2GJMX@201174,4DQKT@85009,COG1595@1,COG1595@2	NA|NA|NA	K	ECF sigma factor
MAG.T22.39_02381	469371.Tbis_3575	6.5e-46	192.2	Pseudonocardiales													Bacteria	2GM4A@201174,4DZGX@85010,COG0515@1,COG0515@2	NA|NA|NA	KLT	serine threonine protein kinase
MAG.T22.39_02382	1504319.GM45_6290	2.7e-103	382.9	unclassified Actinobacteria (class)	murJ			ko:K03980					ko00000,ko01011,ko02000	2.A.66.4			Bacteria	2GKN0@201174,3UWJN@52018,COG0728@1,COG0728@2	NA|NA|NA	S	MviN-like protein
MAG.T22.39_02383	1048339.KB913029_gene1652	1.6e-57	231.1	Frankiales													Bacteria	2GN00@201174,4ESX8@85013,COG3170@1,COG3170@2	NA|NA|NA	NU	Tfp pilus assembly protein FimV
MAG.T22.39_02384	43354.JOIJ01000001_gene372	4.8e-44	184.1	Pseudonocardiales													Bacteria	2I2DG@201174,4E30H@85010,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
MAG.T22.39_02385	196162.Noca_4681	3.2e-179	634.8	Propionibacteriales	cca		2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019				Bacteria	2GMT1@201174,4DMZV@85009,COG0617@1,COG0617@2	NA|NA|NA	J	Probable RNA and SrmB- binding site of polymerase A
MAG.T22.39_02386	1033730.CAHG01000016_gene542	9.9e-48	198.0	Propionibacteriales													Bacteria	28MY8@1,2GMYY@201174,2ZB54@2,4DNCX@85009	NA|NA|NA		
MAG.T22.39_02387	1048339.KB913029_gene1638	2.1e-34	152.1	Actinobacteria													Bacteria	2CQNK@1,2I83S@201174,323RQ@2	NA|NA|NA	S	Family of unknown function (DUF5318)
MAG.T22.39_02389	1123320.KB889629_gene7852	2.1e-274	951.8	Actinobacteria	pepN		3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Bacteria	2GJJ4@201174,COG0308@1,COG0308@2	NA|NA|NA	E	aminopeptidase N
MAG.T22.39_02390	1120950.KB892765_gene5654	3e-12	79.0	Propionibacteriales		GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	2GTMP@201174,4DS9U@85009,COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
MAG.T22.39_02391	1184607.AUCHE_05_03020	2.4e-194	685.6	Dermatophilaceae	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15	ko:K00700,ko:K00705,ko:K02438,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R02110,R02111,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13,GH77	iJN678.malQ	Bacteria	2GM5Z@201174,4F6IR@85018,COG1640@1,COG1640@2	NA|NA|NA	G	4-alpha-glucanotransferase
MAG.T22.39_02392	1048339.KB913029_gene4943	1e-237	829.7	Frankiales			3.4.21.26	ko:K01322	ko04614,map04614				ko00000,ko00001,ko01000,ko01002				Bacteria	2IRXB@201174,4ERQG@85013,COG1505@1,COG1505@2	NA|NA|NA	E	peptidase S9A, prolyl oligopeptidase domain protein beta-propeller
MAG.T22.39_02393	1479623.JHEL01000015_gene996	7.2e-50	204.5	Microbacteriaceae	mscS			ko:K22044					ko00000,ko02000	1.A.23.3			Bacteria	2GMFK@201174,4FMRA@85023,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive ion channel
MAG.T22.39_02394	269800.Tfu_2215	1.3e-38	166.0	Streptosporangiales	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363		ko:K06886					ko00000				Bacteria	2IKPF@201174,4EJN6@85012,COG2346@1,COG2346@2	NA|NA|NA	S	Bacterial-like globin
MAG.T22.39_02395	452652.KSE_17210	1.5e-175	622.9	Kitasatospora	aglA2		3.2.1.10,3.2.1.20,3.2.1.93	ko:K01182,ko:K01187,ko:K01226	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000		GH13,GH31		Bacteria	2GKS4@201174,2M1TX@2063,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha-amylase domain
MAG.T22.39_02396	1123322.KB904656_gene736	1.4e-15	89.4	Actinobacteria				ko:K07107					ko00000,ko01000				Bacteria	2IFAK@201174,COG0824@1,COG0824@2	NA|NA|NA	S	Thioesterase
MAG.T22.39_02397	1504319.GM45_5705	3.6e-265	920.6	unclassified Actinobacteria (class)	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Bacteria	2GKBQ@201174,3UWE5@52018,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter
MAG.T22.39_02398	68570.DC74_3194	3.7e-24	118.2	Actinobacteria	ssb1			ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	2GQIQ@201174,COG0629@1,COG0629@2	NA|NA|NA	L	single-stranded DNA-binding protein
MAG.T22.39_02402	262316.MAP_0428	5.6e-124	451.1	Mycobacteriaceae	yagA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07497					ko00000				Bacteria	233GJ@1762,2GJ3V@201174,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
MAG.T22.39_02403	517418.Ctha_1865	1.3e-23	119.4	Bacteria				ko:K14645	ko02024,map02024				ko00000,ko00001,ko01000,ko01002,ko03110				Bacteria	COG5184@1,COG5184@2,COG5492@1,COG5492@2	NA|NA|NA	DZ	guanyl-nucleotide exchange factor activity
MAG.T22.39_02404	529884.Rhola_00013260	4.4e-28	131.7	Microbacteriaceae	narL			ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Bacteria	2HT82@201174,4FSEQ@85023,COG2197@1,COG2197@2	NA|NA|NA	KT	helix_turn_helix, Lux Regulon
MAG.T22.39_02405	381666.H16_A1985	1.5e-08	68.2	Burkholderiaceae			2.7.13.3	ko:K02486					ko00000,ko01000,ko01001,ko02022				Bacteria	1K250@119060,1R43J@1224,2VPEB@28216,COG4585@1,COG4585@2	NA|NA|NA	T	PFAM ATP-binding region, ATPase domain protein
MAG.T22.39_02407	570268.ANBB01000001_gene1297	3.9e-31	142.9	Streptosporangiales	copD			ko:K02351,ko:K07245					ko00000,ko02000	9.B.62.1			Bacteria	2GKIR@201174,4EGUX@85012,COG1276@1,COG1276@2,COG3336@1,COG3336@2	NA|NA|NA	P	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
MAG.T22.39_02409	525909.Afer_1707	6e-83	314.7	Acidimicrobiia	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6			Bacteria	2GJHX@201174,4CNMG@84992,COG0843@1,COG0843@2	NA|NA|NA	C	Cytochrome C and Quinol oxidase polypeptide I
MAG.T22.39_02410	471852.Tcur_3867	6.7e-102	377.1	Streptosporangiales	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100		R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011			iYO844.BSU28390	Bacteria	2GN4I@201174,4EIC2@85012,COG0796@1,COG0796@2	NA|NA|NA	M	Provides the (R)-glutamate required for cell wall biosynthesis
MAG.T22.39_02411	935839.JAGJ01000032_gene35	8e-94	350.1	Promicromonosporaceae	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016				Bacteria	2GJFI@201174,4F44Q@85017,COG0689@1,COG0689@2	NA|NA|NA	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MAG.T22.39_02413	33876.JNXY01000031_gene2925	3.1e-33	148.3	Micromonosporales													Bacteria	2GYWG@201174,4DG0Q@85008,COG1403@1,COG1403@2	NA|NA|NA	V	HNH nucleases
MAG.T22.39_02414	1463820.JOGW01000007_gene1973	1.6e-55	222.2	Actinobacteria	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564					ko00000,ko01000			iPC815.YPO3064	Bacteria	2IHZ6@201174,COG1225@1,COG1225@2	NA|NA|NA	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAG.T22.39_02415	68219.JNXI01000019_gene7624	9.5e-63	246.9	Actinobacteria	cbiM			ko:K02007,ko:K16915	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GK2U@201174,COG0310@1,COG0310@2	NA|NA|NA	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MAG.T22.39_02416	467200.ACFA01000530_gene4241	2.2e-19	101.7	Actinobacteria	cbiM			ko:K02007,ko:K16915	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GK2U@201174,COG0310@1,COG0310@2	NA|NA|NA	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MAG.T22.39_02417	1906.SFRA_18950	7.4e-69	267.3	Actinobacteria	cbiQ			ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GKQ7@201174,COG0619@1,COG0619@2	NA|NA|NA	P	Cobalt ABC transporter
MAG.T22.39_02418	711393.AYRX01000017_gene3033	3.6e-105	387.9	Actinobacteria	cbiO			ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23			Bacteria	2GJ0M@201174,COG1122@1,COG1122@2	NA|NA|NA	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system
MAG.T22.39_02420	1210045.ALNP01000007_gene95	3.3e-35	154.5	Actinobacteria	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077		ko:K04078					ko00000,ko03029,ko03110				Bacteria	2IHRC@201174,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MAG.T22.39_02421	1304865.JAGF01000001_gene3904	4.7e-155	554.7	Actinobacteria		GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	2GMUC@201174,COG1233@1,COG1233@2	NA|NA|NA	Q	oxidoreductase
MAG.T22.39_02422	561175.KB894099_gene4904	2.9e-163	581.6	Streptosporangiales	thrC1		4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000				Bacteria	2GNM0@201174,4EI6X@85012,COG0498@1,COG0498@2	NA|NA|NA	E	Pyridoxal-phosphate dependent enzyme
MAG.T22.39_02423	37919.EP51_27970	4.3e-93	347.8	Nocardiaceae													Bacteria	2H1EB@201174,4FXY4@85025,COG1028@1,COG1028@2	NA|NA|NA	IQ	KR domain
MAG.T22.39_02424	1048339.KB913029_gene4300	3.6e-14	84.0	Bacteria	attS												Bacteria	COG1506@1,COG1506@2	NA|NA|NA	E	serine-type peptidase activity
MAG.T22.39_02425	1504319.GM45_3310	3.1e-64	251.9	Bacteria													Bacteria	COG1506@1,COG1506@2	NA|NA|NA	E	serine-type peptidase activity
MAG.T22.39_02427	1297742.A176_01465	1e-16	95.1	Bacteria				ko:K20276	ko02024,map02024				ko00000,ko00001				Bacteria	COG2755@1,COG2755@2,COG5640@1,COG5640@2	NA|NA|NA	O	serine-type endopeptidase activity
# 2104 queries scanned
# Total time (seconds): 4.38493299484
# Rate: 479.82 q/s